Young Sup Yoon

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of
    Young Sup Yoon
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 111:2073-85. 2005
  2. ncbi Angiopoietin-2 stimulates blood flow recovery after femoral artery occlusion by inducing inflammation and arteriogenesis
    Sarah L Tressel
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 28:1989-95. 2008
  3. ncbi Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction
    Young Sup Yoon
    Division of Cardiovascular Medicine, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    J Clin Invest 115:326-38. 2005
  4. ncbi Therapeutic myocardial angiogenesis with vascular endothelial growth factors
    Young Sup Yoon
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    Mol Cell Biochem 264:63-74. 2004
  5. ncbi Myocardial regeneration with bone-marrow-derived stem cells
    Young Sup Yoon
    Division of Cardiovascular Research, Caritas St, Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Biol Cell 97:253-63. 2005
  6. ncbi Unexpected severe calcification after transplantation of bone marrow cells in acute myocardial infarction
    Young Sup Yoon
    Division of Cardiovascular Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge St, Boston, Mass 02135, USA
    Circulation 109:3154-7. 2004
  7. ncbi Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy
    Kengo F Kusano
    Division of Cardiovascular Research, St Elizabeth Medical Center Boston, Boston, MA 02135, USA
    Arterioscler Thromb Vasc Biol 24:2102-7. 2004
  8. ncbi Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart
    Hyun Jai Cho
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    J Exp Med 204:3257-69. 2007
  9. ncbi Hyperhomocyst(e)inemia impairs angiogenesis in a murine model of limb ischemia
    Marta Bosch-Marce
    Department of Medicine Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135 2997, USA
    Vasc Med 10:15-22. 2005
  10. ncbi Autologous transplantation of endothelial progenitor cells genetically modified by adeno-associated viral vector delivering insulin-like growth factor-1 gene after myocardial infarction
    Sabyasachi Sen
    Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Hum Gene Ther 21:1327-34. 2010

Research Grants

  1. Role of Angiogenesis and Endothelial Progenitor Cells in Diabetic Heart Failure
    Young Sup Yoon; Fiscal Year: 2007

Collaborators

Detail Information

Publications30

  1. ncbi Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of
    Young Sup Yoon
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 111:2073-85. 2005
    ..Diabetic cardiomyopathy (DCM) is characterized by microvascular pathology and interstitial fibrosis, which leads to progressive heart failure; however, the pathogenesis of DCM remains uncertain...
  2. ncbi Angiopoietin-2 stimulates blood flow recovery after femoral artery occlusion by inducing inflammation and arteriogenesis
    Sarah L Tressel
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 28:1989-95. 2008
    ..We hypothesized that Ang2 plays an important role in blood flow recovery after arterial occlusion in vivo by regulating angiogenesis and arteriogenesis...
  3. ncbi Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction
    Young Sup Yoon
    Division of Cardiovascular Medicine, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    J Clin Invest 115:326-38. 2005
    ..To our knowledge, this is the first demonstration that a specific population of multipotent human BM-derived stem cells can induce both therapeutic neovascularization and endogenous and exogenous cardiomyogenesis...
  4. ncbi Therapeutic myocardial angiogenesis with vascular endothelial growth factors
    Young Sup Yoon
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    Mol Cell Biochem 264:63-74. 2004
    ....
  5. ncbi Myocardial regeneration with bone-marrow-derived stem cells
    Young Sup Yoon
    Division of Cardiovascular Research, Caritas St, Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Biol Cell 97:253-63. 2005
    ....
  6. ncbi Unexpected severe calcification after transplantation of bone marrow cells in acute myocardial infarction
    Young Sup Yoon
    Division of Cardiovascular Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge St, Boston, Mass 02135, USA
    Circulation 109:3154-7. 2004
    ..Thus far, no significant deleterious effects or complications have been reported in any studies using BM-derived cells for treatment of various cardiac diseases...
  7. ncbi Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy
    Kengo F Kusano
    Division of Cardiovascular Research, St Elizabeth Medical Center Boston, Boston, MA 02135, USA
    Arterioscler Thromb Vasc Biol 24:2102-7. 2004
    ..Accordingly, we investigated the hypothesis that systemic injection of SHh protein could improve nerve blood flow and function in diabetic neuropathy (DN)...
  8. ncbi Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart
    Hyun Jai Cho
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    J Exp Med 204:3257-69. 2007
    ..These data indicate that myocardial EPC transplantation induces humoral effects, which are sustained by host tissues and play a crucial role in repairing myocardial injury...
  9. ncbi Hyperhomocyst(e)inemia impairs angiogenesis in a murine model of limb ischemia
    Marta Bosch-Marce
    Department of Medicine Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135 2997, USA
    Vasc Med 10:15-22. 2005
    ..In contrast, our data suggest that impaired Akt phosphorylation mediates the impairment of angiogenesis associated with HH...
  10. ncbi Autologous transplantation of endothelial progenitor cells genetically modified by adeno-associated viral vector delivering insulin-like growth factor-1 gene after myocardial infarction
    Sabyasachi Sen
    Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Hum Gene Ther 21:1327-34. 2010
    ..Pretreatment with genistein markedly improved AAV transduction of EPCs. IGF-1-expressing EPCs exhibit favorable cell-protective effects with tissue-limited expression in rat heart postinfarction...
  11. ncbi VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema
    Young Sup Yoon
    Department of Vascular Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Clin Invest 111:717-25. 2003
    ..This novel therapeutic strategy may merit clinical investigation in patients with lymphedema...
  12. ncbi Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth
    Rudolf Kirchmair
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 111:2662-70. 2005
    ..The pathogenic basis for toxic neuropathies induced by chemotherapeutic agents has not been completely elucidated...
  13. ncbi Neuronal nitric oxide synthase mediates statin-induced restoration of vasa nervorum and reversal of diabetic neuropathy
    Masaaki Ii
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge St, Boston, MA 02135, USA
    Circulation 112:93-102. 2005
    ..Peripheral neuropathy is a frequent and major complication of diabetes...
  14. ncbi Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization
    Gangjian Qin
    Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135
    J Exp Med 203:153-63. 2006
    ..These data indicate that functional disruption of alpha4 integrin may represent a potential angiogenic therapy for ischemic disease by increasing the available circulating supply of EPCs...
  15. ncbi Bone marrow-derived stem cell therapy in ischemic heart disease
    Hyun-Jai Cho
    Caritas St. Elizabeth's Medical Center, Division of Cardiovascular Research, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Regen Med 1:337-45. 2006
    ..In this review, the authors discuss the therapeutic capacity of currently available representative bone marrow-derived stem and progenitor cells for treating ischemic heart diseases...
  16. ncbi Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling
    Kengo F Kusano
    Division of Cardiovascular Research, St Elizabeth Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Nat Med 11:1197-204. 2005
    ....
  17. ncbi Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia
    Atsuhiko Kawamoto
    Division of Cardiovascular Research, St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 107:461-8. 2003
    ..CONCLUSIONS: These favorable outcomes encourage future clinical trials of catheter-based, intramyocardial transplantation of autologous CD34+ MNCs in the setting of chronic myocardial ischemia...
  18. ncbi Malignant tumor formation after transplantation of short-term cultured bone marrow mesenchymal stem cells in experimental myocardial infarction and diabetic neuropathy
    Jin Ok Jeong
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circ Res 108:1340-7. 2011
    ..Bone marrow (BM)-derived mesenchymal stem cells (MSCs) hold great promise for cardiovascular cell therapy owing to their multipotency and culture expandability...
  19. ncbi The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A
    Raj Kishore
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    J Clin Invest 115:1785-96. 2005
    ....
  20. ncbi Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF
    Rudolf Kirchmair
    Department of Cardiovascular Research, St Elizabeth s Medical Center Tufts University School of Medicine, Boston, Massachusetts, USA
    Mol Ther 15:69-75. 2007
    ..These findings implicate microvascular damage as the basis for toxic neuropathy and suggest that angiogenic growth factors may constitute a novel treatment for this disorder...
  21. ncbi Dual angiogenic and neurotrophic effects of bone marrow-derived endothelial progenitor cells on diabetic neuropathy
    Jin Ok Jeong
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass, USA
    Circulation 119:699-708. 2009
    ..Recent evidence suggested that diabetic neuropathy is causally related to impaired angiogenesis and deficient growth factors. Accordingly, we investigated whether diabetic neuropathy could be reversed by local transplantation of EPCs...
  22. ncbi Repair of ischemic heart disease with novel bone marrow-derived multipotent stem cells
    Namho Lee
    Division of Cardiovascular Research, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Cell Cycle 4:861-4. 2005
    ..In this review, we will discuss the currently available bone marrow-derived stem progenitor cells for myocardial repair and focus on the advantages of using recently identified novel bone marrow-derived multipotent stem cells (BMSC)...
  23. ncbi Endothelial progenitor thrombospondin-1 mediates diabetes-induced delay in reendothelialization following arterial injury
    Masaaki Ii
    Division of Cardiovascular Research, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circ Res 98:697-704. 2006
    ....
  24. ncbi Local gene transfer of phVEGF-2 plasmid by gene-eluting stents: an alternative strategy for inhibition of restenosis
    Dirk H Walter
    Department of Medicine, St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 110:36-45. 2004
    ..VEGF-2 gene-eluting stents may be considered as a stand-alone or combination therapy...
  25. ncbi Derivation and characterization of bone marrow-derived multipotent stem cells
    Jiyoon Lee
    Division of Cardiovascular Research, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Exp Hematol 34:1602-3. 2006
  26. ncbi Engineering the response to vascular injury: divergent effects of deregulated E2F1 expression on vascular smooth muscle cells and endothelial cells result in endothelial recovery and inhibition of neointimal growth
    David A Goukassian
    Department of Medicine, Division of Cardiovascular Research, St Elizabeth's Medical Center, Boston, Mass, USA
    Circ Res 93:162-9. 2003
    ....
  27. ncbi Synergism of hematopoietic cytokines for infarct repair
    Hyun-Jai Cho
    Circ Res 98:990-2. 2006
  28. ncbi All in the family: VEGF-B joins the ranks of proangiogenic cytokines
    Young-sup Yoon
    Circ Res 93:87-90. 2003
  29. ncbi Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction
    Sara Weis
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 113:885-94. 2004
    ..These findings define a molecular mechanism to account for the Src requirement in VEGF-mediated permeability and provide a basis for Src inhibition as a therapeutic option for patients with acute MI...
  30. ncbi Treatment of thoracic aortic dissection with stent-grafts: midterm results
    Won Heum Shim
    Division of Cardiology, Yonsei Cardiovascular Center and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea
    J Endovasc Ther 9:817-21. 2002
    ..To evaluate the early and midterm outcomes after stent-graft implantation for dissection in the descending thoracic aorta...

Research Grants1

  1. Role of Angiogenesis and Endothelial Progenitor Cells in Diabetic Heart Failure
    Young Sup Yoon; Fiscal Year: 2007
    ....