Dayong Wu

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. pmc Leptin differentially regulate STAT3 activation in ob/ob mouse adipose mesenchymal stem cells
    Zhou Zhou
    Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, MI 48824, USA
    Nutr Metab (Lond) 9:109. 2012
  2. doi request reprint Diet-induced obesity has a differential effect on adipose tissue and macrophage inflammatory responses of young and old mice
    Dayong Wu
    Nutritional Immunology Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Biofactors 39:326-33. 2013
  3. pmc Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit
    Junpeng Wang
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab (Lond) 10:29. 2013
  4. doi request reprint Green tea EGCG, T cells, and T cell-mediated autoimmune diseases
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
    Mol Aspects Med 33:107-18. 2012
  5. ncbi request reprint Green tea EGCG suppresses T cell proliferation through impairment of IL-2/IL-2 receptor signaling
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Free Radic Biol Med 47:636-43. 2009
  6. ncbi request reprint Aging up-regulates expression of inflammatory mediators in mouse adipose tissue
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer Unites States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Immunol 179:4829-39. 2007
  7. ncbi request reprint Dietary supplementation with white button mushroom enhances natural killer cell activity in C57BL/6 mice
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 137:1472-7. 2007
  8. ncbi request reprint Vitamin E increases production of vasodilator prostanoids in human aortic endothelial cells through opposing effects on cyclooxygenase-2 and phospholipase A2
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 135:1847-53. 2005
  9. ncbi request reprint Effect of vitamin E on prostacyclin (PGI2) and prostaglandin (PG) E2 production by human aorta endothelial cells: mechanism of action
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:425-7. 2004
  10. ncbi request reprint Effect of concomitant consumption of fish oil and vitamin E on production of inflammatory cytokines in healthy elderly humans
    Dayong Wu
    D V M, Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:422-4. 2004

Collaborators

Detail Information

Publications43

  1. pmc Leptin differentially regulate STAT3 activation in ob/ob mouse adipose mesenchymal stem cells
    Zhou Zhou
    Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, MI 48824, USA
    Nutr Metab (Lond) 9:109. 2012
    ..abstract:..
  2. doi request reprint Diet-induced obesity has a differential effect on adipose tissue and macrophage inflammatory responses of young and old mice
    Dayong Wu
    Nutritional Immunology Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Biofactors 39:326-33. 2013
    ..This age-related difference in response to HF diet should be considered when using inflammation status as a marker in investigating adverse health impacts of HF diet and obesity...
  3. pmc Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit
    Junpeng Wang
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab (Lond) 10:29. 2013
    ..This study sought to determine if curcumin could potentiate CR's beneficial effect on immune and inflammatory responses in obesity developed in mice by feeding high-fat diet (HFD)...
  4. doi request reprint Green tea EGCG, T cells, and T cell-mediated autoimmune diseases
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
    Mol Aspects Med 33:107-18. 2012
    ..Data from human studies are essentially absent and thus are urgently needed...
  5. ncbi request reprint Green tea EGCG suppresses T cell proliferation through impairment of IL-2/IL-2 receptor signaling
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Free Radic Biol Med 47:636-43. 2009
    ....
  6. ncbi request reprint Aging up-regulates expression of inflammatory mediators in mouse adipose tissue
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer Unites States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Immunol 179:4829-39. 2007
    ....
  7. ncbi request reprint Dietary supplementation with white button mushroom enhances natural killer cell activity in C57BL/6 mice
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 137:1472-7. 2007
    ..This effect might be mediated through increased IFNgamma and TNFalpha production...
  8. ncbi request reprint Vitamin E increases production of vasodilator prostanoids in human aortic endothelial cells through opposing effects on cyclooxygenase-2 and phospholipase A2
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 135:1847-53. 2005
    ..The vitamin E-induced increase in PGI(2) and PGE(2) production may contribute to its suggested beneficial effect in preserving endothelial function...
  9. ncbi request reprint Effect of vitamin E on prostacyclin (PGI2) and prostaglandin (PG) E2 production by human aorta endothelial cells: mechanism of action
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:425-7. 2004
    ..This effect of vitamin E is due to increased release of substrate arachidonic acid, which in turn results from increased expression of phospholipase A(2) (PLA(2))...
  10. ncbi request reprint Effect of concomitant consumption of fish oil and vitamin E on production of inflammatory cytokines in healthy elderly humans
    Dayong Wu
    D V M, Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:422-4. 2004
    ....
  11. ncbi request reprint Modulation of immune and inflammatory responses by dietary lipids
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 15:43-7. 2004
    ..Analysis of the recent findings will help in understanding certain paradoxical findings as well as introducing new strategies to guide future studies...
  12. ncbi request reprint Mechanism of age-associated up-regulation in macrophage PGE2 synthesis
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Brain Behav Immun 18:487-94. 2004
    ..Further understanding of molecular mechanisms involved in COX-2 up-regulation will help in delineating fundamental age-related changes, which lead to the development of immune and neurological disorders in the aged...
  13. pmc Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse
    Shu Wang
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Atherosclerosis 204:147-55. 2009
    ..These data suggest that lower omega-6:EPA+DHA ratio diets lowered some measures of inflammation and Mphi cholesterol accumulation, which was associated with less aortic lesion formation in LDLr-/- mice...
  14. ncbi request reprint Epigallocatechin-3-gallate directly suppresses T cell proliferation through impaired IL-2 utilization and cell cycle progression
    Munkyong Pae
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 140:1509-15. 2010
    ..CD4(+) cells are more responsive to EGCG than CD8(+) cells. Future studies should determine the effect of EGCG on CD4(+) cell subsets to assess its application in T cell-mediated autoimmune diseases...
  15. doi request reprint Effect of dietary supplementation with white button mushrooms on host resistance to influenza infection and immune function in mice
    Yanmei Xu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Br J Nutr 109:1052-61. 2013
    ..These mushroom-induced systemic changes, however, were not adequate to confer a protective effect against influenza infection...
  16. doi request reprint Dietary supplementation with high dose of epigallocatechin-3-gallate promotes inflammatory response in mice
    Munkyong Pae
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 23:526-31. 2012
    ....
  17. ncbi request reprint Effect of age on susceptibility to azoxymethane-induced colonic aberrant crypt foci formation in C57BL/6JNIA mice
    Heekyung Chung
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 58:B400-5. 2003
    ..These age differences are not due to variations in cyclooxygenase-2 expression, cell proliferation, or AOM hydroxylase activity...
  18. pmc Enhanced aortic macrophage lipid accumulation and inflammatory response in LDL receptor null mice fed an atherogenic diet
    Shu Wang
    Cardiovascular Nutrition Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Lipids 45:701-11. 2010
    ....
  19. doi request reprint Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice
    Asma Ejaz
    Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:919-25. 2009
    ..Our findings suggest that dietary curcumin may have a potential benefit in preventing obesity...
  20. doi request reprint Dietary supplementation with lacto-wolfberry enhances the immune response and reduces pathogenesis to influenza infection in mice
    Zhihong Ren
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 142:1596-602. 2012
    ....
  21. ncbi request reprint Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated through up-regulation of NF-kappa B activity
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 278:10983-92. 2003
    ..These findings strongly suggest that the age-associated and ceramide-induced increase in COX-2 transcription is mediated through higher NF-kappa B activation, which is, in turn, because of a greater I kappa B degradation in old M phi...
  22. ncbi request reprint Age-associated decline in effective immune synapse formation of CD4(+) T cells is reversed by vitamin E supplementation
    Melissa G Marko
    Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Immunol 178:1443-9. 2007
    ..These data show, for the first time, that vitamin E significantly improves age-related early T cell signaling events in naive CD4(+) T cells...
  23. ncbi request reprint Dietary supplementation with tocotrienols enhances immune function in C57BL/6 mice
    Zhihong Ren
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 140:1335-41. 2010
    ..Together, these results suggest a beneficial effect of T3 in improving the age-related decline in T cell function...
  24. ncbi request reprint White button mushroom enhances maturation of bone marrow-derived dendritic cells and their antigen presenting function in mice
    Zhihong Ren
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 138:544-50. 2008
    ..This effect may have potential in enhancing both innate and T cell-mediated immunity leading to a more efficient surveillance and defense mechanism against microbial invasion and tumor development...
  25. pmc Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction
    Alberto Molano
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America
    PLoS ONE 7:e47650. 2012
    ..These results suggest that reductions in glucosylceramide abundance contribute to age-related impairments in CD4(+) T cell function...
  26. pmc Effect of age on susceptibility to Salmonella Typhimurium infection in C57BL/6 mice
    Zhihong Ren
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Med Microbiol 58:1559-67. 2009
    ..Typhimurium infection compared to young mice...
  27. pmc Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention
    Dayong Wu
    Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    J Leukoc Biol 84:900-14. 2008
    ..This review will discuss the above age-related immune and inflammatory changes and the effect of vitamin E as nutritional intervention with a focus on the work conducted in our laboratory...
  28. doi request reprint Avenanthramides inhibit proliferation of human colon cancer cell lines in vitro
    Weimin Guo
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Nutr Cancer 62:1007-16. 2010
    ..Our results suggest that the consumption of oats and oat bran may reduce the risk of colon cancer not only because of their high fiber content but also due to Avns, which attenuate proliferation of colonic cancer cells...
  29. ncbi request reprint Effect of concomitant consumption of fish oil and vitamin E on T cell mediated function in the elderly: a randomized double-blind trial
    Dayong Wu
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Am Coll Nutr 25:300-6. 2006
    ..To determine if concomitant consumption of fish oil and vitamin E would modify the vitamin E level needed for improving T cell mediated function in elderly...
  30. doi request reprint Nutrition and age-associated inflammation: implications for disease prevention
    Simin Nikbin Meydani
    JMUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    JPEN J Parenter Enteral Nutr 32:626-9. 2008
    ..Nutrient/dietary medications, such as antioxidants and certain lipids have suggested a promising route to reduce the age-related increase in COX activity and PGE(2) production that is associated with several disease states...
  31. doi request reprint Immunomodulating effects of epigallocatechin-3-gallate from green tea: mechanisms and applications
    Munkyong Pae
    Cellular and Molecular Physiology Section, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
    Food Funct 4:1287-303. 2013
    ..Given the paucity of information in human studies, the translational value of these findings needs to be verified in future research. ..
  32. ncbi request reprint Vitamin E supplementation does not alter azoxymethane-induced colonic aberrant crypt foci formation in young or old mice
    Heekyung Chung
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:528-32. 2003
    ..Whether vitamin E supplementation might be effective in reducing AOM-induced colon tumors is unclear...
  33. ncbi request reprint Vitamin E and immune response in the aged: molecular mechanisms and clinical implications
    Simin Nikbin Meydani
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Immunol Rev 205:269-84. 2005
    ..Further studies are needed to determine the signaling mechanisms involved in the upregulation of naive T-cell function by vitamin E as well as the specific mechanisms involved in reduction of risk for upper respiratory infections...
  34. doi request reprint Green tea epigallocatechin-3-gallate modulates differentiation of naïve CD4⁺ T cells into specific lineage effector cells
    Junpeng Wang
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Mol Med (Berl) 91:485-95. 2013
    ..Together, our results suggest that EGCG modulates development of CD4(+) T cell lineages through impacting their respective and interactive regulatory networks ultimately leading to an attenuated autoimmune response...
  35. doi request reprint Epigallocatechin-3-gallate ameliorates experimental autoimmune encephalomyelitis by altering balance among CD4+ T-cell subsets
    Junpeng Wang
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Sackler Graduate School of Biochemical Sciences, Tufts University, Boston, Massachusetts 02111, USA
    Am J Pathol 180:221-34. 2012
    ..Thus, we identified a novel mechanism that underlies EGCG's beneficial effect in autoimmune disease...
  36. ncbi request reprint Ceramide mediates age-associated increase in macrophage cyclooxygenase-2 expression
    Kate J Claycombe
    Nutritional Immunology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center at Tufts University, 711 Washington Street, Boston, MA 02111
    J Biol Chem 277:30784-91. 2002
    ..Furthermore, this increase in transcription is mediated by higher cellular ceramide concentration in old MØ compared with that of young MØ...
  37. ncbi request reprint Mechanism of vitamin E inhibition of cyclooxygenase activity in macrophages from old mice: role of peroxynitrite
    Alison A Beharka
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Free Radic Biol Med 32:503-11. 2002
    ..These findings have important implications for designing interventions to reverse and/or delay age-associated dysregulation of immune and inflammatory responses and diseases associated with them...
  38. doi request reprint Epigallocatechin-3-gallate inhibits expression of receptors for T cell regulatory cytokines and their downstream signaling in mouse CD4+ T cells
    Junpeng Wang
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 142:566-71. 2012
    ..This implies a potential application in controlling dysregulated T cell functions such as those observed in autoimmune and inflammatory disorders...
  39. pmc In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation
    Shu Wang
    JM USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Br J Nutr 102:497-501. 2009
    ..In summary, individual long-chain PUFA have differential effects on inflammatory response and markers of cholesterol flux in MPhi which are not related to the n position of the first double bond, chain length or degree of saturation...
  40. ncbi request reprint Vitamin E supplementation reverses the age-associated decrease in effective immune synapse formation in CD4+ T cells
    Tanvir Ahmed
    Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:412-4. 2004
    ..Further studies are under way to determine the mechanisms of age and VE-induced enhancement of effective immune synapse formation...
  41. ncbi request reprint Age-associated inflammatory changes: role of nutritional intervention
    Simin Nikbin Meydani
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University Boston, Massachussetts 02111, USA
    Nutr Rev 65:S213-6. 2007
    ....
  42. pmc The role of nutrition in enhancing immunity in aging
    Munkyong Pae
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Aging Dis 3:91-129. 2012
    ....
  43. ncbi request reprint Deletion of TNF-like weak inducer of apoptosis (TWEAK) protects mice from adipose and systemic impacts of severe obesity
    Grace Bennett
    Obesity and Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 22:1485-94. 2014
    ..To investigate the role of TNF-like weak inducer of apoptosis (TWEAK) in pathological adipose tissue (AT) remodeling and complications of obesity...