Dayong Wu

..This study sought to determine if curcumin could potentiate CR's beneficial effect on immune and inflammatory responses in obesity developed in mice by feeding high-fat diet (HFD)...

..Data from human studies are essentially absent and thus are urgently needed...

..This effect might be mediated through increased IFNgamma and TNFalpha production...

..This effect of vitamin E is due to increased release of substrate arachidonic acid, which in turn results from increased expression of phospholipase A(2) (PLA(2))...

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..Further understanding of molecular mechanisms involved in COX-2 up-regulation will help in delineating fundamental age-related changes, which lead to the development of immune and neurological disorders in the aged...

..Analysis of the recent findings will help in understanding certain paradoxical findings as well as introducing new strategies to guide future studies...

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..The vitamin E-induced increase in PGI(2) and PGE(2) production may contribute to its suggested beneficial effect in preserving endothelial function...

..These data suggest that lower omega-6:EPA+DHA ratio diets lowered some measures of inflammation and Mphi cholesterol accumulation, which was associated with less aortic lesion formation in LDLr-/- mice...

..CD4(+) cells are more responsive to EGCG than CD8(+) cells. Future studies should determine the effect of EGCG on CD4(+) cell subsets to assess its application in T cell-mediated autoimmune diseases...

..These mushroom-induced systemic changes, however, were not adequate to confer a protective effect against influenza infection...

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..These age differences are not due to variations in cyclooxygenase-2 expression, cell proliferation, or AOM hydroxylase activity...

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..These findings strongly suggest that the age-associated and ceramide-induced increase in COX-2 transcription is mediated through higher NF-kappa B activation, which is, in turn, because of a greater I kappa B degradation in old M phi...

..All T3 enhanced lymphocyte proliferation in old but not young mice with a potency order of alpha- > gamma- > delta-T3. Together, these results suggest a beneficial effect of T3 in improving the age-related decline in T cell function...

..This effect may have potential in enhancing both innate and T cell-mediated immunity leading to a more efficient surveillance and defense mechanism against microbial invasion and tumor development...

..These data show, for the first time, that vitamin E significantly improves age-related early T cell signaling events in naive CD4(+) T cells...

..These results suggest that reductions in glucosylceramide abundance contribute to age-related impairments in CD4(+) T cell function...

..Our results suggest that the consumption of oats and oat bran may reduce the risk of colon cancer not only because of their high fiber content but also due to Avns, which attenuate proliferation of colonic cancer cells...

..CONCLUSIONS: The immuno-enhancing effect of vitamin E in the elderly is dampened when it is concomitantly consumed with fish oil. This may be due to the smaller increase in plasma concentrations of vitamin E in the presence of fish oil...

..Typhimurium infection compared to young mice...

..Nutrient/dietary medications, such as antioxidants and certain lipids have suggested a promising route to reduce the age-related increase in COX activity and PGE(2) production that is associated with several disease states...

..This review will discuss the above age-related immune and inflammatory changes and the effect of vitamin E as nutritional intervention with a focus on the work conducted in our laboratory...

..Our findings suggest that dietary curcumin may have a potential benefit in preventing obesity...

..Whether vitamin E supplementation might be effective in reducing AOM-induced colon tumors is unclear...

..Further studies are needed to determine the signaling mechanisms involved in the upregulation of naive T-cell function by vitamin E as well as the specific mechanisms involved in reduction of risk for upper respiratory infections...

..Thus, we identified a novel mechanism that underlies EGCG's beneficial effect in autoimmune disease...

..These findings have important implications for designing interventions to reverse and/or delay age-associated dysregulation of immune and inflammatory responses and diseases associated with them...

..Furthermore, this increase in transcription is mediated by higher cellular ceramide concentration in old MØ compared with that of young MØ...

..This implies a potential application in controlling dysregulated T cell functions such as those observed in autoimmune and inflammatory disorders...

..Further studies are under way to determine the mechanisms of age and VE-induced enhancement of effective immune synapse formation...

..In summary, individual long-chain PUFA have differential effects on inflammatory response and markers of cholesterol flux in MPhi which are not related to the n position of the first double bond, chain length or degree of saturation...

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..Together, our results suggest that EGCG modulates development of CD4(+) T cell lineages through impacting their respective and interactive regulatory networks ultimately leading to an attenuated autoimmune response...

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