Xiang Dong Wang

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Alcohol, vitamin A, and cancer
    Xiang Dong Wang
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Alcohol 35:251-8. 2005
  2. pmc Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice
    Blanche C Ip
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Room 514, Boston, MA 02111
    Cancer Prev Res (Phila) 6:1304-16. 2013
  3. pmc Lycopene metabolism and its biological significance
    Xiang Dong Wang
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 96:1214S-22S. 2012
  4. ncbi request reprint Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?
    Xiang Dong Wang
    Nutrition and Cancer Biology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 135:2053S-6S. 2005
  5. ncbi request reprint Combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model
    Yuri Kim
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Carcinogenesis 27:1410-9. 2006
  6. ncbi request reprint Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Cancer Res 63:3138-44. 2003
  7. pmc Combined α-tocopherol and ascorbic acid protects against smoke-induced lung squamous metaplasia in ferrets
    Yuri Kim
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Lung Cancer 75:15-23. 2012
  8. pmc Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats
    Yan Wang
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Int J Cancer 126:1788-96. 2010
  9. ncbi request reprint Beta-cryptoxanthin suppresses the growth of immortalized human bronchial epithelial cells and non-small-cell lung cancer cells and up-regulates retinoic acid receptor beta expression
    Fuzhi Lian
    Nutrition and Cancer Biology Laboratory, Jean Mayer Unite States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Int J Cancer 119:2084-9. 2006
  10. ncbi request reprint 9-cis-Retinoic acid inhibition of lung carcinogenesis in the A/J mouse model is accompanied by increased expression of RAR-beta but no change in cyclooxygenase-2
    Heather Mernitz
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cancer Lett 244:101-8. 2006

Research Grants

  1. Lycopene Chemoprevention of Lung Cancer in Ferret
    Xiang Dong Wang; Fiscal Year: 2010
  2. ALCOHOL INTAKE AND RETINOID METABOLISM AND SIGNALING
    Xiang Dong Wang; Fiscal Year: 2002
  3. Lycopene Chemoprevention of Lung Cancer in Ferret
    Xiang Dong Wang; Fiscal Year: 2009
  4. Lycopene Chemoprevention of Lung Cancer in Ferret
    Xiang Dong Wang; Fiscal Year: 2007
  5. Lycopene Chemoprevention of Lung Cancer in Ferret
    Xiang Dong Wang; Fiscal Year: 2006
  6. ALCOHOL INTAKE AND RETINOID METABOLISM AND SIGNALING
    Xiang Dong Wang; Fiscal Year: 2004
  7. ALCOHOL INTAKE AND RETINOID METABOLISM AND SIGNALING
    Xiang Dong Wang; Fiscal Year: 2003
  8. Biologic Activity of Lycopene
    Xiang Dong Wang; Fiscal Year: 2002
  9. Lycopene Chemoprevention of Lung Cancer in Ferret
    Xiang Dong Wang; Fiscal Year: 2009

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Alcohol, vitamin A, and cancer
    Xiang Dong Wang
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Alcohol 35:251-8. 2005
    ....
  2. pmc Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice
    Blanche C Ip
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Room 514, Boston, MA 02111
    Cancer Prev Res (Phila) 6:1304-16. 2013
    ..Taken together, these data indicate that APO10LA can effectively inhibit HFD-promoted hepatic tumorigenesis by stimulating SIRT1 signaling while reducing hepatic inflammation...
  3. pmc Lycopene metabolism and its biological significance
    Xiang Dong Wang
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 96:1214S-22S. 2012
    ....
  4. ncbi request reprint Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?
    Xiang Dong Wang
    Nutrition and Cancer Biology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 135:2053S-6S. 2005
  5. ncbi request reprint Combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model
    Yuri Kim
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Carcinogenesis 27:1410-9. 2006
    ....
  6. ncbi request reprint Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Cancer Res 63:3138-44. 2003
    ....
  7. pmc Combined α-tocopherol and ascorbic acid protects against smoke-induced lung squamous metaplasia in ferrets
    Yuri Kim
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Lung Cancer 75:15-23. 2012
    ..These data indicate that the combination of antioxidant AT+AA alone exerts protective effects against SM-induced lung lesions through inhibiting cyclin D1 expression and partially restoring retinoic acid levels to normal...
  8. pmc Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats
    Yan Wang
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Int J Cancer 126:1788-96. 2010
    ..These data indicate that LY and TE can inhibit NASH-promoted hepatocarcinogenesis mainly as a result of reduced oxidative stress, which could be fulfilled through different mechanisms...
  9. ncbi request reprint Beta-cryptoxanthin suppresses the growth of immortalized human bronchial epithelial cells and non-small-cell lung cancer cells and up-regulates retinoic acid receptor beta expression
    Fuzhi Lian
    Nutrition and Cancer Biology Laboratory, Jean Mayer Unite States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Int J Cancer 119:2084-9. 2006
    ..These findings suggest a mechanism of anti-proliferative action of beta-cryptoxanthin and indicate that beta-cryptoxanthin may be a promising chemopreventive agent against lung cancer...
  10. ncbi request reprint 9-cis-Retinoic acid inhibition of lung carcinogenesis in the A/J mouse model is accompanied by increased expression of RAR-beta but no change in cyclooxygenase-2
    Heather Mernitz
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cancer Lett 244:101-8. 2006
    ..These results suggest that 9cRA supplementation may provide protection against lung carcinogenesis and this effect may be mediated in part by 9cRA induction of RAR-beta, but not inhibition of COX-2 transcription...
  11. ncbi request reprint Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): a model for human lung cancer
    Yuri Kim
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cancer Lett 234:209-19. 2006
    ....
  12. ncbi request reprint Alpha-tocopherol and ascorbic acid decrease the production of beta-apo-carotenals and increase the formation of retinoids from beta-carotene in the lung tissues of cigarette smoke-exposed ferrets in vitro
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 134:426-30. 2004
    ....
  13. ncbi request reprint Retinoic acid inhibits hepatic Jun N-terminal kinase-dependent signaling pathway in ethanol-fed rats
    Jayong Chung
    Molecular Carcinogenesis Section, Gastrointestinal Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, MA 02111, USA
    Oncogene 21:1539-47. 2002
    ..The results from these studies indicate that restoration of RA homeostasis is critical for the regulation of JNK-dependent signaling pathway and apoptosis in the liver of ethanol-fed rats...
  14. pmc β-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice
    Anita R Iskandar
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Cancer Prev Res (Phila) 6:309-20. 2013
    ..In addition, our study establishes a relevant animal lung cancer model for studying tumor growth within emphysematous microenvironments...
  15. ncbi request reprint Inhibition of lung carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity
    Heather Mernitz
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Int J Cancer 120:1402-9. 2007
    ..The underlying mechanism behind this effect does not appear to be related to retinoid modulation of vitamin D catabolism...
  16. ncbi request reprint Alcohol-reduced plasma IGF-I levels and hepatic IGF-I expression can be partially restored by retinoic acid supplementation in rats
    Fuzhi Lian
    Jean Mayer U S D A Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 134:2953-6. 2004
    ..These data suggest that alcohol-impaired hepatic RA status contributes to the decreased plasma IGF-I level and hepatic IGF-I expression in alcoholics...
  17. ncbi request reprint Low dose beta-carotene supplementation of ferrets attenuates smoke-induced lung phosphorylation of JNK, p38 MAPK, and p53 proteins
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 134:2705-10. 2004
    ..These data provide supportive evidence that the beneficial vs. detrimental effects of beta-carotene supplementation are related to the dosage of beta-carotene administered...
  18. pmc Fish oil supplementation inhibits NNK-induced lung carcinogenesis in the A/J mouse
    Heather Mernitz
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Nutr Cancer 61:663-9. 2009
    ..These data suggest that fish oil with a low ratio of n-6/n-3 PUFA could be beneficial in the prevention of lung carcinogenesis...
  19. pmc Long-term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in rats
    Pollyanna R G Chavez
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 141:1049-55. 2011
    ..Together, these results indicate that chronic, excessive ethanol consumption impairs normal hepatocyte proliferation, which is associated with reduced IGF-1 levels, but promotes hepatic carcinogenesis...
  20. ncbi request reprint The effects of combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation on antioxidant capacity, DNA single-strand breaks and levels of insulin-like growth factor-1/IGF-binding protein 3 in the ferret model of lung cancer
    Yuri Kim
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Int J Cancer 120:1847-54. 2007
    ..Differential expression of IGFBP-3 in different tissues indicates that caution should be taken when using plasma IGFBP-3 as a biomarker of tissue status...
  21. ncbi request reprint Exposing ferrets to cigarette smoke and a pharmacological dose of beta-carotene supplementation enhance in vitro retinoic acid catabolism in lungs via induction of cytochrome P450 enzymes
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 133:173-9. 2003
    ....
  22. pmc β-Cryptoxanthin supplementation prevents cigarette smoke-induced lung inflammation, oxidative damage, and squamous metaplasia in ferrets
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cancer Prev Res (Phila) 4:1255-66. 2011
    ..Data from this study indicate that β-cryptoxanthin provides a beneficial effect against cigarette smoke-induced inflammation, oxidative DNA damage and squamous metaplasia in the lungs...
  23. ncbi request reprint Beta-carotene and beta-apo-14'-carotenoic acid prevent the reduction of retinoic acid receptor beta in benzo[a]pyrene-treated normal human bronchial epithelial cells
    Pankaj Prakash
    Nutrition and Cancer Biology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, School of Medicine, Tufts University, Boston, MA 02111, USA
    J Nutr 134:667-73. 2004
    ..These observations indicate that the growth inhibitory effects of BC and beta-apo-carotenoic acid are through their conversion to RA and upregulation of RARbeta...
  24. ncbi request reprint Apo-10'-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo
    Fuzhi Lian
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Carcinogenesis 28:1567-74. 2007
    ..These observations demonstrate that apo-10'-lycopenoic acid is a biological active metabolite of lycopene and suggest that apo-10'-lycopenoic acid is a potential chemopreventive agent against lung tumorigenesis...
  25. ncbi request reprint Chlormethiazole treatment prevents reduced hepatic vitamin A levels in ethanol-fed rats
    Chun Liu
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Alcohol Clin Exp Res 26:1703-9. 2002
    ..This study investigated whether treatment with chlormethiazole, a CYP inhibitor, restores vitamin A in the livers of ethanol-fed rats...
  26. pmc Apo-10'-lycopenoic acid, a lycopene metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice
    Jayong Chung
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 142:405-10. 2012
    ..Because SIRT1 plays a key role in lipid homeostasis, the present study suggests that the lycopene metabolite, ALA, protects against the development of steatosis in ob/ob mice by upregulating SIRT1 gene expression and activity...
  27. pmc Increased apoptosis in high-fat diet-induced nonalcoholic steatohepatitis in rats is associated with c-Jun NH2-terminal kinase activation and elevated proapoptotic Bax
    Yan Wang
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 138:1866-71. 2008
    ....
  28. ncbi request reprint The effect of dietary glutathione and coenzyme Q10 on the prevention and treatment of inflammatory bowel disease in mice
    Chun Liu
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Int J Vitam Nutr Res 74:74-85. 2004
    ..Further studies using additional animal models are required to determine whether GSH or CoQ10 provide a favorable or unfavorable benefit:risk ratio in the prevention or treatment of IBD...
  29. ncbi request reprint Lycopene supplementation prevents smoke-induced changes in p53, p53 phosphorylation, cell proliferation, and apoptosis in the gastric mucosa of ferrets
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 136:106-11. 2006
    ..These data indicate that lycopene may prevent smoke exposure-induced changes in p53, p53 phosphorylation, p53 target genes, cell proliferation, and apoptosis in the gastric mucosa of ferrets...
  30. pmc Enzymatic formation of apo-carotenoids from the xanthophyll carotenoids lutein, zeaxanthin and β-cryptoxanthin by ferret carotene-9',10'-monooxygenase
    Jonathan R Mein
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Arch Biochem Biophys 506:109-21. 2011
    ....
  31. pmc Chronic alcohol intake upregulates hepatic expression of carotenoid cleavage enzymes and PPAR in rats
    Renata A M Luvizotto
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 140:1808-14. 2010
    ..This process may be due to alcohol-induced PPARγ expression and lower vitamin A status in the liver...
  32. pmc Moderate alcohol consumption aggravates high-fat diet induced steatohepatitis in rats
    Yan Wang
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Alcohol Clin Exp Res 34:567-73. 2010
    ..Nonalcoholic steatohepatitis (NASH) develops in the absence of chronic and excessive alcohol consumption. However, it remains unknown whether moderate alcohol consumption aggravates liver inflammation in pre-existing NASH condition...
  33. pmc Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats
    Yan Wang
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Int J Cancer 124:540-6. 2009
    ..These data clearly demonstrate that NASH induced by HFD promoted DEN-initiated early hepatocarcinogenesis, which was associated with elevated TNF-alpha/NF-kappaB signaling and MAPK related hepatocyte proliferation...
  34. pmc Enzymatic metabolites of lycopene induce Nrf2-mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells
    Fuzhi Lian
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Int J Cancer 123:1262-8. 2008
    ..These data strongly suggest that the anti-carcinogenic and antioxidant functions of lycopene may be mediated by apo-10'-lycopenoids via activating Nrf2 and inducing phase II detoxifying/antioxidant enzymes...
  35. pmc The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo
    Kang Quan Hu
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 281:19327-38. 2006
    ....
  36. ncbi request reprint A simple HPLC method for the comprehensive analysis of cis/trans (Z/E) geometrical isomers of carotenoids for nutritional studies
    Antonio J Meléndez-Martínez
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Food Chem 138:1341-50. 2013
    ..This is to the best of our knowledge the report of the highest number of carotenoid geometrical isomers separated with a HPLC method. Twenty-six different carotenoid isomers were readily detected in the biological samples...
  37. doi request reprint Biological activity of lycopene metabolites: implications for cancer prevention
    Jonathan R Mein
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Nutr Rev 66:667-83. 2008
    ..This notion has been reinforced by the observation of both beneficial and detrimental effects of carotenoid metabolites in cancer prevention...
  38. pmc High dose lycopene supplementation increases hepatic cytochrome P4502E1 protein and inflammation in alcohol-fed rats
    Sudipta Veeramachaneni
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 138:1329-35. 2008
    ..These data indicate an interaction between chronic alcohol ingestion and lycopene supplementation and suggest a need for caution among individuals consuming high amounts of both alcohol and lycopene...
  39. ncbi request reprint 9-Cis retinoic acid reduces 1alpha,25-dihydroxycholecalciferol-induced renal calcification by altering vitamin K-dependent gamma-carboxylation of matrix gamma-carboxyglutamic acid protein in A/J male mice
    Xueyan Fu
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 138:2337-41. 2008
    ..The mechanisms by which 9-cis RA and 1,25(OH)(2)D3 alter vitamin K concentrations warrant further investigation...
  40. ncbi request reprint Carotenoids and lung cancer prevention
    Sudipta Veeramachaneni
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Front Biosci (Schol Ed) 1:258-74. 2009
    ....
  41. doi request reprint A pilot study of the photoprotective effect of almond phytochemicals in a 3D human skin equivalent
    Julie A Evans-Johnson
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Photochem Photobiol B 126:17-25. 2013
    ..05). In conclusion, we validated the feasibility of using HSE in evaluation of photoprotectants and found that AT and AP, applied to medium or topically, provided some degree of photoprotection against UVA. ..
  42. pmc Modulation of lung molecular biomarkers by beta-carotene in the Physicians' Health Study
    Chun Liu
    Nutrition and Cancer Biology Laboratory, US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Cancer 115:1049-58. 2009
    ..The objective of the current investigation was to evaluate how long-term beta-carotene supplementation affects molecular markers of lung carcinogenesis in the PHS...
  43. ncbi request reprint Retinoids and alcohol-related carcinogenesis
    Xiang Dong Wang
    Nutrition and Cancer Biology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 133:287S-290S. 2003
    ..These studies indicate the importance of RA actions in the prevention and/or treatment of alcohol-related carcinogenic process in the liver and other organs...
  44. pmc Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention
    Blanche C Ip
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Nutrients 6:124-62. 2014
    ..More research is clearly needed to fully unravel the importance of BCOs in tomato carotenoid metabolism and the consequence on human health and diseases. ..
  45. ncbi request reprint Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response
    Bernard Meshi
    UBC McDonald Research Laboratories, The iCAPTURE Center, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 26:52-7. 2002
    ..In this study, the increase in CD4 was associated with cigarette smoke and the increase in CD8 cells with latent Ad infection...
  46. ncbi request reprint [Interleukin-5 regulate the bone marrow response in the model of allergic rhinitis]
    Xiang Dong Wang
    Beijing Tongren Center of Otorhinolaryngology Head Neck Surgery, Department of Otorhinolaryngology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China
    Zhonghua Er Bi Yan Hou Ke Za Zhi 38:448-50. 2003
    ..To elucidate the mechanism of bone marrow response regulated by interleukin-5 (IL-5) in the model of allergic rhinitis...
  47. ncbi request reprint [A study of the link between upper and lower respiratory inflammation]
    Xiang Dong Wang
    Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China
    Zhonghua Er Bi Yan Hou Ke Za Zhi 38:247-50. 2003
    ..To evaluate the correlation between upper and lower respiratory inflammation...
  48. ncbi request reprint Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential
    Zili Dan
    Laboratory of Liver Research, Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    FASEB J 19:845-7. 2005
    ..No toxicity was found with equivalent doses of the control extract from nonalcoholic rats. We demonstrate that polar retinol metabolites cause marked hepatocyte death through the induction of apoptosis...
  49. pmc Vitamin C supplementation does not protect L-gulono-gamma-lactone oxidase-deficient mice from Helicobacter pylori-induced gastritis and gastric premalignancy
    Chung Wei Lee
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Int J Cancer 122:1068-76. 2008
    ..pylori-induced premalignant gastric lesions. In addition, less severe gastric lesions in H.pylori infected gulo(-/-) mice supplemented with low vitamin C correlated with an attenuated Th1 inflammatory response...

Research Grants10

  1. Lycopene Chemoprevention of Lung Cancer in Ferret
    Xiang Dong Wang; Fiscal Year: 2010
    ..In addition, the establishment of a lung carcinogenesis model in ferrets provides a valuable tool for both lung cancer and carotenoid research fields. ..
  2. ALCOHOL INTAKE AND RETINOID METABOLISM AND SIGNALING
    Xiang Dong Wang; Fiscal Year: 2002
    ....
  3. Lycopene Chemoprevention of Lung Cancer in Ferret
    Xiang Dong Wang; Fiscal Year: 2009
    ..In addition, the establishment of a lung carcinogenesis model in ferrets provides a valuable tool for both lung cancer and carotenoid research fields. ..
  4. Lycopene Chemoprevention of Lung Cancer in Ferret
    Xiang Dong Wang; Fiscal Year: 2007
    ..In addition, the establishment of a lung carcinogenesis model in ferrets provides a valuable tool for both lung cancer and carotenoid research fields. ..
  5. Lycopene Chemoprevention of Lung Cancer in Ferret
    Xiang Dong Wang; Fiscal Year: 2006
    ..In addition, the establishment of a lung carcinogenesis model in ferrets provides a valuable tool for both lung cancer and carotenoid research fields. ..
  6. ALCOHOL INTAKE AND RETINOID METABOLISM AND SIGNALING
    Xiang Dong Wang; Fiscal Year: 2004
    ....
  7. ALCOHOL INTAKE AND RETINOID METABOLISM AND SIGNALING
    Xiang Dong Wang; Fiscal Year: 2003
    ....
  8. Biologic Activity of Lycopene
    Xiang Dong Wang; Fiscal Year: 2002
    ..These studies will provide important information for the potential future use of lycopene as cancer preventive nutrient at different tissue sites and the knowledge of possible adverse effects with tobacco. ..
  9. Lycopene Chemoprevention of Lung Cancer in Ferret
    Xiang Dong Wang; Fiscal Year: 2009
    ..In addition, the establishment of a lung carcinogenesis model in ferrets provides a valuable tool for both lung cancer and carotenoid research fields. ..