DAVID WALT

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Fiber optic array biosensors
    David R Walt
    Tufts University, Medford, MA, USA
    Biotechniques 41:529, 531, 533 passim. 2006
  2. ncbi request reprint Protein measurements in microwells
    David R Walt
    Tufts University, Department of Chemistry, Medford, MA 02155, USA
    Lab Chip 14:3195-200. 2014
  3. pmc Detecting biological warfare agents
    Linan Song
    Tufts University, Medford, Massachusetts, USA
    Emerg Infect Dis 11:1629-32. 2005
  4. pmc Observing single enzyme molecules interconvert between activity states upon heating
    Marcin J Rojek
    Department of Chemistry, Tufts University, Medford, Massachusetts, United States of America
    PLoS ONE 9:e86224. 2014
  5. ncbi request reprint A fiber-optic lactate sensor based on bacterial cytoplasmic membranes
    S G Ignatov
    State Research Center for Applied Microbiology, Obolensk, Moscow Region, Russia
    Biosens Bioelectron 16:109-13. 2001
  6. pmc An automated integrated platform for rapid and sensitive multiplexed protein profiling using human saliva samples
    Shuai Nie
    Department of Chemistry, Tufts University, Medford, MA 02155, USA
    Lab Chip 14:1087-98. 2014
  7. doi request reprint Dynamic microbead arrays for biosensing applications
    Mael Manesse
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts, USA
    Lab Chip 13:2153-60. 2013
  8. pmc Oil-sealed femtoliter fiber-optic arrays for single molecule analysis
    Huaibin Zhang
    Department of Chemistry, Tufts University, Medford, Massachusetts, USA
    Lab Chip 12:2229-39. 2012
  9. ncbi request reprint Imaging optical sensor arrays
    David R Walt
    Max Tishler Laboratory for Organic Chemistry, Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA
    Curr Opin Chem Biol 6:689-95. 2002
  10. doi request reprint Bead-based optical fiber arrays for artificial olfaction
    David R Walt
    Tufts University, Department of Chemistry, Medford, MA 02155, USA
    Curr Opin Chem Biol 14:767-70. 2010

Collaborators

  • David J Monk
  • EVA JOSEPHINE HELMERHORST
  • FRANK OPPENHEIM
  • Eliora Z Ron
  • Zhaohui Li
  • Myoyong Lee
  • Frederic F Little
  • Walter L Siqueira
  • P H Seeberger
  • David M Rissin
  • Yina Kuang
  • Hans H Gorris
  • Jason R Epstein
  • Linan Song
  • Soohyoun Ahn
  • Israel Biran
  • Timothy M Blicharz
  • Tania Konry
  • Matthew J Aernecke
  • Sabine Szunerits
  • Shuai Nie
  • Huaibin Zhang
  • Ryan B Hayman
  • Christopher N LaFratta
  • Christopher DiCesare
  • Michaela Bowden
  • Marcin J Rojek
  • Mael Manesse
  • Alexei R Faustov
  • Jenny M Tam
  • Ragnhild Dragøy Whitaker
  • Ragnhild D Whitaker
  • William J Blake
  • Jason R E Shepard
  • Kathryn L Brogan
  • Kyong Hoon Lee
  • Eddie W Adams
  • Ahmet Z Uluer
  • J Michael Ramsey
  • Patty J Dennis
  • Scott E Miller
  • Yue Wu
  • W Hampton Henley
  • Emily A Oblath
  • Jean Pierre Alarie
  • Peidong Wang
  • Kathryn M Mayer
  • Manuel A Palacios
  • Aaron F Phillips
  • S G Ignatov
  • Raymond M Wang
  • Candice M Etson
  • Michael R Webb
  • Sameer Sonkusale
  • Jian Guo
  • Philip J Wexler
  • Jasvinder S Bhatia
  • Joseph Loscalzo
  • Nerline Grand-Pierre
  • Donald M Anderson
  • David M Kulis
  • Michael A Kohanski
  • Kevin F Murphy
  • Deana L Erdner
  • GABOR BALAZSI
  • Charles R Cantor
  • Farren J Isaacs
  • James J Collins
  • Yechezkel Kashi
  • Yael Danin-Poleg
  • Daniel M Ratner
  • Barry R O'Keefe
  • Jane A Ferguson
  • Amy P K Leung
  • Jörn Ueberfeld
  • J A Ferguson

Detail Information

Publications56

  1. ncbi request reprint Fiber optic array biosensors
    David R Walt
    Tufts University, Medford, MA, USA
    Biotechniques 41:529, 531, 533 passim. 2006
    ..Finally, individual enzyme molecules can be loaded into the array wells enabling single molecule detection via enzyme-catalyzed signal amplification...
  2. ncbi request reprint Protein measurements in microwells
    David R Walt
    Tufts University, Department of Chemistry, Medford, MA 02155, USA
    Lab Chip 14:3195-200. 2014
    ..This Insight discusses the present status of microwell arrays for making protein measurements and describes some of the fundamental challenges as well as opportunities for using microwells in the future. ..
  3. pmc Detecting biological warfare agents
    Linan Song
    Tufts University, Medford, Massachusetts, USA
    Emerg Infect Dis 11:1629-32. 2005
    ..We simultaneously identified multiple biological warfare agents in environmental samples by looking at specific probe responses after hybridization and response patterns of the multiplexed array...
  4. pmc Observing single enzyme molecules interconvert between activity states upon heating
    Marcin J Rojek
    Department of Chemistry, Tufts University, Medford, Massachusetts, United States of America
    PLoS ONE 9:e86224. 2014
    ..This study demonstrates that different stable conformations play an important role in the static heterogeneity reported previously, resulting in distinct long-lived activity states of enzyme molecules in a population. ..
  5. ncbi request reprint A fiber-optic lactate sensor based on bacterial cytoplasmic membranes
    S G Ignatov
    State Research Center for Applied Microbiology, Obolensk, Moscow Region, Russia
    Biosens Bioelectron 16:109-13. 2001
    ..The disk is fixed mechanically over an oxygen sensitive siloxane layer on the distal end of an optical fiber. This system detects lactate with no interference from glucose, fructose or glutamic acid...
  6. pmc An automated integrated platform for rapid and sensitive multiplexed protein profiling using human saliva samples
    Shuai Nie
    Department of Chemistry, Tufts University, Medford, MA 02155, USA
    Lab Chip 14:1087-98. 2014
    ..This platform, which combines noninvasive sample collection and fully automated analysis, can also be utilized in point-of-care diagnostics. ..
  7. doi request reprint Dynamic microbead arrays for biosensing applications
    Mael Manesse
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts, USA
    Lab Chip 13:2153-60. 2013
    ....
  8. pmc Oil-sealed femtoliter fiber-optic arrays for single molecule analysis
    Huaibin Zhang
    Department of Chemistry, Tufts University, Medford, Massachusetts, USA
    Lab Chip 12:2229-39. 2012
    ..We have further demonstrated that this femtoliter fiber-optic array can be integrated into a PDMS microfluidic channel system and sealed with oil on-chip, creating an easy to use and high-throughput device for single-molecule analysis...
  9. ncbi request reprint Imaging optical sensor arrays
    David R Walt
    Max Tishler Laboratory for Organic Chemistry, Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA
    Curr Opin Chem Biol 6:689-95. 2002
    ..The extremely small sizes and volumes of the wells enable high sensitivity and high information content sensing capabilities...
  10. doi request reprint Bead-based optical fiber arrays for artificial olfaction
    David R Walt
    Tufts University, Department of Chemistry, Medford, MA 02155, USA
    Curr Opin Chem Biol 14:767-70. 2010
    ..Portable instrumentation enables the sensor arrays to be used for important field applications. Finally, the artificial nose arrays can be used to test hypotheses about the biological olfactory system...
  11. doi request reprint Fibre optic microarrays
    David R Walt
    Department of Chemistry, Tufts University, Medford, MA 02116, USA
    Chem Soc Rev 39:38-50. 2010
    ..In addition, these microarrays can serve as a substrate for fundamental studies of single molecules and single cells. The review covers topics of interest to chemists, biologists, materials scientists, and engineers...
  12. ncbi request reprint Ubiquitous sensors: when will they be here?
    David R Walt
    Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA
    ACS Nano 3:2876-80. 2009
    ..The availability of inexpensive sensors for wide-scale deployment will transform society in terms of health care as well as home and workplace monitoring...
  13. ncbi request reprint Chemistry. Miniature analytical methods for medical diagnostics
    David R Walt
    Department of Chemistry, Tufts University, Medford, MA 02155, USA
    Science 308:217-9. 2005
  14. ncbi request reprint Microsensor arrays for saliva diagnostics
    David R Walt
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, MA 02155, USA
    Ann N Y Acad Sci 1098:389-400. 2007
    ..These results are reported in the second part of this article...
  15. pmc Fiber-optic microsphere-based antibody array for the analysis of inflammatory cytokines in saliva
    Timothy M Blicharz
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA
    Anal Chem 81:2106-14. 2009
    ..This array technology may prove useful as a laboratory-based platform for inflammatory disease research and diagnostics, and its small footprint could also enable integration into a microfluidic cassette for use in point-of-care testing...
  16. ncbi request reprint Optical fiber-based biosensors
    David J Monk
    Department of Chemistry, Pearson Lab, Tufts University, 62 Talbot Ave, Medford, MA 02155, USA
    Anal Bioanal Chem 379:931-45. 2004
    ....
  17. ncbi request reprint Optical-fiber bundles
    Hans H Gorris
    Department of Chemistry, Tufts University, Medford, MA 02155, USA
    FEBS J 274:5462-70. 2007
    ..Finally, the microwells have been sealed to enclose single enzyme molecules that can be used to measure individual molecule catalytic activity...
  18. ncbi request reprint Optical imaging fiber-based live bacterial cell array biosensor
    Israel Biran
    The Max Tishler Laboratory for Organic Chemistry, Department of Chemistry, Tufts University, Medford, MA 02155, USA
    Anal Biochem 315:106-13. 2003
    ..The optical imaging fiber-based single bacterial cell array is a flexible and sensitive biosensor platform that can be used to monitor the expression of different reporter genes and accommodate a variety of sensing strains...
  19. pmc Microsphere-based rolling circle amplification microarray for the detection of DNA and proteins in a single assay
    Tania Konry
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA
    Anal Chem 81:5777-82. 2009
    ..In addition to this new approach for detecting both protein and DNA in a single test using RCA, the limit of detection for IL-8 and IL-6 was improved by 3 orders of magnitude compared to similar microsphere-based assays...
  20. ncbi request reprint Monitoring "promiscuous" drug effects on single cells of multiple cell types
    Yina Kuang
    Department of Chemistry, Tufts University, Medford, MA 02155, USA
    Anal Biochem 345:320-5. 2005
    ....
  21. ncbi request reprint Optical imaging fiber-based single live cell arrays: a high-density cell assay platform
    Israel Biran
    Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA
    Anal Chem 74:3046-54. 2002
    ....
  22. ncbi request reprint High-density, microsphere-based fiber optic DNA microarrays
    Jason R Epstein
    The Max Tishler Laboratory for Organic Chemistry, Tufts University, Medford, MA 02155, USA
    Biosens Bioelectron 18:541-6. 2003
    ..Fiber optic microsphere-based DNA microarrays have a simple fabrication protocol enabling their expansion into other applications, such as single cell-based assays...
  23. ncbi request reprint Fluorescence-based fibre optic arrays: a universal platform for sensing
    Jason R Epstein
    Max Tishler Laboratory for Organic Chemistry, Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA
    Chem Soc Rev 32:203-14. 2003
    ..A number of sensing schemes and applications are described in this review...
  24. doi request reprint Temporally resolved fluorescence spectroscopy of a microarray-based vapor sensing system
    Matthew J Aernecke
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA
    Anal Chem 81:5762-9. 2009
    ..The ability to measure the entire fluorescence spectrum from each sensor simultaneously during a vapor exposure increases the dimensionality of the response data and significantly improves the classification accuracy of the system...
  25. ncbi request reprint Combinatorial decoding: an approach for universal DNA array fabrication
    Jason R Epstein
    Max Tishler Laboratory for Organic Chemistry, Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA
    J Am Chem Soc 125:13753-9. 2003
    ..Once mapped, the microsphere array can be used for any typical genomic microarray experiment...
  26. doi request reprint DNA detection on ultrahigh-density optical fiber-based nanoarrays
    Jenny M Tam
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, MA 02155, United States
    Biosens Bioelectron 24:2488-93. 2009
    ....
  27. doi request reprint Very high density sensing arrays
    Christopher N LaFratta
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, MA 02155, USA
    Chem Rev 108:614-37. 2008
  28. ncbi request reprint Living bacterial cell array for genotoxin monitoring
    Yina Kuang
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA
    Anal Chem 76:2902-9. 2004
    ..Dose-response curves for several genotoxins were obtained. The biosensors demonstrated an active sensing lifetime of more than 6 h and a shelf lifetime of two weeks...
  29. ncbi request reprint Detection of Salmonella spp. using microsphere-based, fiber-optic DNA microarrays
    Soohyoun Ahn
    Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA
    Anal Chem 77:5041-7. 2005
    ..Since fiber-optic microarrays can be prepared with different probes, this approach could also enable the simultaneous detection of multiple food pathogens...
  30. ncbi request reprint Fiber-optic microsphere-based arrays for multiplexed biological warfare agent detection
    Linan Song
    Department of Chemistry, Tufts University, Medford, MA 02155, USA
    Anal Chem 78:1023-33. 2006
    ....
  31. ncbi request reprint Digital concentration readout of single enzyme molecules using femtoliter arrays and Poisson statistics
    David M Rissin
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA
    Nano Lett 6:520-3. 2006
    ..This approach should prove useful for single molecule enzymology and ultrasensitive bioassays. More generally, the ability to determine concentration by counting individual molecules offers a new approach to analysis of dilute solutions...
  32. ncbi request reprint Detecting oxygen consumption in the proximity of Saccharomyces cerevisiae cells using self-assembled fluorescent nanosensors
    Yina Kuang
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA
    Biotechnol Bioeng 96:318-25. 2007
    ....
  33. doi request reprint Mechanistic aspects of horseradish peroxidase elucidated through single-molecule studies
    Hans H Gorris
    Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA
    J Am Chem Soc 131:6277-82. 2009
    ..The mechanism not only affects single-molecule studies with HRP but also bulk reactions at low substrate turnover rates...
  34. ncbi request reprint Encoded fiber-optic microsphere arrays for probing protein-carbohydrate interactions
    Eddie W Adams
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Angew Chem Int Ed Engl 42:5317-20. 2003
  35. doi request reprint Detection of single-molecule DNA hybridization using enzymatic amplification in an array of femtoliter-sized reaction vessels
    Zhaohui Li
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA
    J Am Chem Soc 130:12622-3. 2008
    ..We expect this assay to be useful in a number of biomedical applications where accurate and highly sensitive target analysis is critical...
  36. pmc Use of colorimetric test strips for monitoring the effect of hemodialysis on salivary nitrite and uric acid in patients with end-stage renal disease: a proof of principle
    Timothy M Blicharz
    Department of Chemistry, Tufts University, Medford, MA 02155, USA
    Clin Chem 54:1473-80. 2008
    ..We observed that salivary nitrite (NO(2)(-)) and uric acid (UA) concentrations consistently decreased as dialysis proceeded...
  37. ncbi request reprint Digital readout of target binding with attomole detection limits via enzyme amplification in femtoliter arrays
    David M Rissin
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA
    J Am Chem Soc 128:6286-7. 2006
    ..This capture and readout approach should prove useful for DNA and antibody assays that utilize an enzyme label to catalyze the generation of a fluorescent signal...
  38. pmc Fiber-optic microarray for simultaneous detection of multiple harmful algal bloom species
    Soohyoun Ahn
    Department of Chemistry, Tufts University, 62 Talbot Ave, Medford, MA 02155, USA
    Appl Environ Microbiol 72:5742-9. 2006
    ..Our study suggests that fiber-optic microarrays can be used for rapid and sensitive detection and potential enumeration of HAB species in the environment...
  39. ncbi request reprint Optical fiber-based sensors: application to chemical biology
    Kathryn L Brogan
    Department of Chemistry, Tufts University, Medford, MA 02155, USA
    Curr Opin Chem Biol 9:494-500. 2005
    ..Both single-core optical fiber sensors and optical fiber sensor arrays have been used for sensing based on nucleic acids and live cells...
  40. ncbi request reprint Fabrication of an optoelectrochemical microring array
    Sabine Szunerits
    Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA
    Anal Chem 74:1718-23. 2002
    ....
  41. ncbi request reprint High-density fiber-optic genosensor microsphere array capable of zeptomole detection limits
    Jason R Epstein
    The Max Tishler Laboratory for Organic Chemistry, Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA
    Anal Chem 74:1836-40. 2002
    ..Specific hybridization was observed for each of three sequences in an array yielding a detection limit of 10(-21) mol (approximately 600 DNA molecules)...
  42. ncbi request reprint Aluminum surface corrosion and the mechanism of inhibitors using pH and metal ion selective imaging fiber bundles
    Sabine Szunerits
    Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA
    Anal Chem 74:886-94. 2002
    ..From the number and extent of corrosion sites and the release of aluminum ions monitored with the fiber, it was shown that 8-hydroxyquinoline is a more effective inhibitor than cerium chloride...
  43. pmc Note: Toward multiple addressable optical trapping
    Alexei R Faustov
    Department of Chemistry, 62 Talbot Avenue, Tufts University, Medford, Massachusetts 02155, USA
    Rev Sci Instrum 81:026109. 2010
    ..In this paper, we report a proof-of-principle single beam/single micromirror/single three-dimensional trap arrangement that should serve as the basis for a multiple-trap instrument...
  44. ncbi request reprint The use of optical fiber bundles combined with electrochemistry for chemical imaging
    Sabine Szunerits
    Max Tishler Laboratory for Organic Chemistry, Department of Chemistry, Tufts University, Medford, MA 02155, USA
    Chemphyschem 4:186-92. 2003
    ....
  45. ncbi request reprint Fiber-based single cell analysis of reporter gene expression in yeast two-hybrid systems
    Ragnhild Dragøy Whitaker
    Department of Chemistry, Tufts University, Medford, MA 02155, USA
    Anal Biochem 360:63-74. 2007
    ..The system is based on statistical analysis of many yeast cells contained in a fiber-optic array, allowing for thorough characterization of reporter gene expression at different stringency levels...
  46. ncbi request reprint Development of a microfluidic platform with an optical imaging microarray capable of attomolar target DNA detection
    Michaela Bowden
    Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA
    Anal Chem 77:5583-8. 2005
    ..This paper describes the initial development, optimization, and integration of the microfluidic platform with imaging fiber arrays...
  47. pmc Intelligent medical diagnostics via molecular logic
    Tania Konry
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA
    J Am Chem Soc 131:13232-3. 2009
    ..One possible application of this technique would be direct screening of various medical conditions that are dependent on combinations of diagnostic markers...
  48. ncbi request reprint Design, implementation, and field testing of a portable fluorescence-based vapor sensor
    Matthew J Aernecke
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA
    Anal Chem 81:5281-90. 2009
    ....
  49. ncbi request reprint Individual cell migration analysis using fiber-optic bundles
    Christopher DiCesare
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, MA 02155, USA
    Anal Bioanal Chem 382:37-43. 2005
    ..The subcellular imaging platform allows for rapid analysis of migratory potential, reducing experimental time from several hours in a standard assay to 5 min using this technology...
  50. ncbi request reprint Multianalyte single-cell analysis with multiple cell lines using a fiber-optic array
    Ragnhild D Whitaker
    Chemistry Department, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA
    Anal Chem 79:9045-53. 2007
    ..The development of this single-cell drug screening method is presented, and fluorescent and statistical analyses of single-cell dynamic responses are discussed...
  51. pmc Stochastic inhibitor release and binding from single-enzyme molecules
    Hans H Gorris
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, MA 02155, USA
    Proc Natl Acad Sci U S A 104:17680-5. 2007
    ..We proved that the rate constants of inhibitor release and binding derived from stochastic changes in the substrate turnover are consistent with bulk-reaction kinetics...
  52. ncbi request reprint Simultaneously monitoring gene expression kinetics and genetic noise in single cells by optical well arrays
    Yina Kuang
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA
    Anal Chem 76:6282-6. 2004
    ..These data are invaluable for investigating gene regulation and gene networks as well as for systems biology applications...
  53. ncbi request reprint Array-based binary analysis for bacterial typing
    Jason R E Shepard
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, MA 02155, USA
    Anal Chem 77:319-26. 2005
    ..Because of the advantages of the fiber-optic array platform over other array formats, including sensitivity and speed, the platform described in this paper is capable of supporting a high-throughput diagnostic strategy...
  54. doi request reprint Distinct and long-lived activity states of single enzyme molecules
    David M Rissin
    Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA
    J Am Chem Soc 130:5349-53. 2008
    ..If the results reported here can be generalized to other enzymes, then the stochastic nature of individual enzyme molecule kinetics should have a substantial impact on the overall metabolic activity within a cell...
  55. ncbi request reprint Smells like bread
    David R Walt
    Nat Chem Biol 3:306-7. 2007
  56. ncbi request reprint Phenotypic consequences of promoter-mediated transcriptional noise
    William J Blake
    Department of Biomedical Engineering, Massachusetts, USA
    Mol Cell 24:853-65. 2006
    ..We experimentally verify computational predictions that the rapid response and increased cell-cell variability enabled by TATA-containing promoters confer a clear benefit in the face of an acute environmental stress...

Research Grants8

  1. Development of new tools for Single Cell Analysis
    David R Walt; Fiscal Year: 2011
    ..The goal of this project is to develop new tools for analyzing single cells to characterize and understand the differences between cells in a population. ..
  2. Microsensor Arrays for Saliva Diagnostics
    DAVID WALT; Fiscal Year: 2007
    ..We will demonstrate efficacy of the system at the lab bench and later provide one Alpha and three Beta units to the clinical investigators for pilot studies and expanded field trials. ..
  3. Microsensor Arrays for Saliva Diagnostics
    DAVID WALT; Fiscal Year: 2005
    ..Much of the initial work will be directed at screening potentially useful sensing chemistries for their applicability to sensing components in saliva. ..
  4. Optical Tweezer Arrays Based on Optical Imaging Fibers
    DAVID WALT; Fiscal Year: 2005
    ..The technology has applicability to cell selection, blood and tumor diagnosis, combinatorial screening, nanoassembly, gene expression analysis and a wide variety of screening, selection, and diagnostic applications. ..
  5. Optical Tweezer Arrays Based on Optical Imaging Fibers
    DAVID WALT; Fiscal Year: 2006
    ..The technology has applicability to cell selection, blood and tumor diagnosis, combinatorial screening, nanoassembly, gene expression analysis and a wide variety of screening, selection, and diagnostic applications. ..
  6. Optical Tweezer Arrays Based on Optical Imaging Fibers
    DAVID WALT; Fiscal Year: 2007
    ..The technology has applicability to cell selection, blood and tumor diagnosis, combinatorial screening, nanoassembly, gene expression analysis and a wide variety of screening, selection, and diagnostic applications. ..
  7. Microsensor Arrays for Saliva Diagnostics
    DAVID WALT; Fiscal Year: 2007
    ..We will demonstrate efficacy of the system at the lab bench and later provide one Alpha and three Beta units to the clinical investigators for pilot studies and expanded field trials. ..