Kenneth Walsh

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals
    E Suzuki
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Genomics 38:283-90. 1996
  2. ncbi request reprint Cell cycle exit upon myogenic differentiation
    K Walsh
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Curr Opin Genet Dev 7:597-602. 1997
  3. ncbi request reprint Is extravasation a Fas-regulated process?
    K Walsh
    Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02135, USA
    Mol Med Today 5:61-7. 1999
  4. ncbi request reprint Apoptosis in inflammatory-fibroproliferative disorders of the vessel wall
    K Walsh
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Boston, MA 02135, USA
    Cardiovasc Res 45:756-65. 2000
  5. ncbi request reprint Transcriptional regulation of vascular smooth muscle cell phenotype
    K Walsh
    Division of Cardiovascular Research, St Elizabeth s Medical Center, 736 Cambridge Street, Boston, MA 02135, USA
    Z Kardiol 90:12-6. 2001
  6. pmc The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling
    Carsten Skurk
    Boston University School of Medicine, Whitaker Cardiovascular Institute, Boston, Massachusetts 02118, USA
    J Biol Chem 280:20814-23. 2005
  7. ncbi request reprint Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:1304-9. 2004
  8. pmc Adiponectin-mediated modulation of hypertrophic signals in the heart
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, Massachusetts 02118, USA
    Nat Med 10:1384-9. 2004
  9. ncbi request reprint Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells
    Md Ruhul Abid
    Department of Medicine, Beth Israel Deaconess Medical Center, RW 663, Boston, MA 02215, USA
    Arterioscler Thromb Vasc Biol 24:294-300. 2004
  10. pmc Activin A and follistatin-like 3 determine the susceptibility of heart to ischemic injury
    Yuichi Oshima
    Molecular Cardiology Unit, Whitaker Cardiovascular Institute, Boston University Medical Campus, Boston, Mass 02118, USA
    Circulation 120:1606-15. 2009

Detail Information

Publications79

  1. ncbi request reprint The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals
    E Suzuki
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Genomics 38:283-90. 1996
    ..These data demonstrate that GATA-6 is subject to both tissue-specific and mitogen-responsive regulatory signals. GATA-6 is a prime candidate for a gene that might regulate the differentiative state of VSMCs...
  2. ncbi request reprint Cell cycle exit upon myogenic differentiation
    K Walsh
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Curr Opin Genet Dev 7:597-602. 1997
    ..The coordinated regulation of cell proliferation and death provides the developing embryo with a mechanism for controlling muscle mass and thereby the size of individual motor units...
  3. ncbi request reprint Is extravasation a Fas-regulated process?
    K Walsh
    Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02135, USA
    Mol Med Today 5:61-7. 1999
    ....
  4. ncbi request reprint Apoptosis in inflammatory-fibroproliferative disorders of the vessel wall
    K Walsh
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Boston, MA 02135, USA
    Cardiovasc Res 45:756-65. 2000
    ..In toto, these studies suggest that apoptosis is prevalent in vascular lesions, controlling the viability of both inflammatory and vascular cells, and thus determining the cellular composition of the vessel wall...
  5. ncbi request reprint Transcriptional regulation of vascular smooth muscle cell phenotype
    K Walsh
    Division of Cardiovascular Research, St Elizabeth s Medical Center, 736 Cambridge Street, Boston, MA 02135, USA
    Z Kardiol 90:12-6. 2001
    ..In this paper, we will review the role of these transcription factors in VSMC differentiation and proliferation...
  6. pmc The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling
    Carsten Skurk
    Boston University School of Medicine, Whitaker Cardiovascular Institute, Boston, Massachusetts 02118, USA
    J Biol Chem 280:20814-23. 2005
    ..Thus, in cardiomyocytes, as in skeletal muscle, FOXO3a activates an atrogene transcriptional program, which retards or prevents hypertrophy and is down-regulated by multiple physiological and pathological stimuli of myocyte growth...
  7. ncbi request reprint Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:1304-9. 2004
    ..These data indicate that adiponectin can function to stimulate the new blood vessel growth by promoting cross-talk between AMP-activated protein kinase and Akt signaling within endothelial cells...
  8. pmc Adiponectin-mediated modulation of hypertrophic signals in the heart
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, Massachusetts 02118, USA
    Nat Med 10:1384-9. 2004
    ..Adiponectin may have utility for the treatment of hypertrophic cardiomyopathy associated with diabetes and other obesity-related diseases...
  9. ncbi request reprint Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells
    Md Ruhul Abid
    Department of Medicine, Beth Israel Deaconess Medical Center, RW 663, Boston, MA 02215, USA
    Arterioscler Thromb Vasc Biol 24:294-300. 2004
    ..In this study, we examined whether VEGF is coupled to phosphatidyl inositol 3-kinase (PI3K)/Akt/forkhead in ECs...
  10. pmc Activin A and follistatin-like 3 determine the susceptibility of heart to ischemic injury
    Yuichi Oshima
    Molecular Cardiology Unit, Whitaker Cardiovascular Institute, Boston University Medical Campus, Boston, Mass 02118, USA
    Circulation 120:1606-15. 2009
    ..Follistatin-like 3 (Fstl3) is an extracellular regulator of activin A protein, and its function in the heart is also unknown...
  11. pmc Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity
    Noriyuki Ouchi
    Molecular Cardiology and Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    Science 329:454-7. 2010
    ..Thus, in the setting of obesity, Sfrp5 secretion by adipocytes exerts salutary effects on metabolic dysfunction by controlling inflammatory cells within adipose tissue...
  12. ncbi request reprint Glycogen-Synthase Kinase3beta/beta-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells
    Carsten Skurk
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
    Circ Res 96:308-18. 2005
    ..Collectively, these data show that the growth factor-PI3-kinase-Akt axis functions downstream of GSK3beta/beta-catenin signaling in endothelial cells to promote angiogenesis...
  13. pmc Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease
    Ross Summer
    The Pulmonary Center, R 304, Boston Univ School of Medicine, 80 East Concord St, Boston, MA 02118, USA
    Am J Physiol Lung Cell Mol Physiol 297:L432-8. 2009
    ....
  14. ncbi request reprint Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street W611, Boston, Massachusetts 02118, USA
    J Biol Chem 279:28670-4. 2004
    ..Therefore, adiponectin may be useful in the treatment for obesity-related vascular deficiency diseases...
  15. pmc Adiponectin protects against the development of systolic dysfunction following myocardial infarction
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    J Mol Cell Cardiol 42:1065-74. 2007
    ....
  16. pmc Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction
    Yasumasa Ikeda
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 284:35839-49. 2009
    ..Cardiac hypertrophy and dysfunction in LKB1-deficient hearts are associated with alterations in AMPK and mTOR/p70S6 kinase/eEF2 signaling and with a reduction in vascular endothelial growth factor expression and vessel rarefaction...
  17. ncbi request reprint Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure
    Stephan Schiekofer
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Physiol Genomics 27:156-70. 2006
    ..These data define the gene regulatory programs downstream of Akt that control heart size and contribute to the transition from compensatory hypertrophy to heart failure...
  18. ncbi request reprint The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP
    Carsten Skurk
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:1513-25. 2004
    ..These data suggest that FOXO3a is a downstream target of Akt in endothelial cells that can promote apoptosis via FLIP down-regulation and activation of the extrinsic apoptotic pathway...
  19. pmc Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response
    Masayuki Shimano
    Whitaker Cardiovascular Institute, Boston University Medical Campus, Boston, MA, USA
    J Mol Cell Cardiol 49:210-20. 2010
    ..Collectively, these data show that adiponectin deficiency can accelerate the transition from cardiac hypertrophy to heart failure during pressure overload through disruption of AMPK-dependent angiogenic regulatory axis...
  20. pmc Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure
    Ichiro Shiojima
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Invest 115:2108-18. 2005
    ..Thus, both heart size and cardiac function are angiogenesis dependent, and disruption of coordinated tissue growth and angiogenesis in the heart contributes to the progression from adaptive cardiac hypertrophy to heart failure...
  21. pmc Adiponectin promotes revascularization of ischemic muscle through a cyclooxygenase 2-dependent mechanism
    Koji Ohashi
    Molecular Cardiology Section, Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    Mol Cell Biol 29:3487-99. 2009
    ..Thus, disruption of the adiponectin-COX-2 regulatory axis in endothelial cells could participate in the pathogenesis of obesity-related vascular diseases...
  22. pmc Adiponectin suppresses pathological microvessel formation in retina through modulation of tumor necrosis factor-alpha expression
    Akiko Higuchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Circ Res 104:1058-65. 2009
    ..These data provide evidence that adiponectin protects against retinal vessel injury following pathological stimuli through modulation of TNF-alpha inflammatory responses...
  23. pmc Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload
    Yasuhiro Izumiya
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Hypertension 47:887-93. 2006
    ..These findings suggest that VEGF is required to maintain myocardial capillary density and that reductions in the vascular bed are associated with the transition from compensatory hypertrophy to failure...
  24. pmc Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 283:32802-11. 2008
    ....
  25. pmc Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure
    Flora Sam
    Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Endocrinology 151:322-31. 2010
    ..Therefore, hypoadiponectinemia in hypertension-induced diastolic HF exacerbates LVH, diastolic dysfunction, and diastolic HF. Whether or not adiponectin replacement prevents the progression to diastolic HF will warrant further study...
  26. pmc LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis
    Koji Ohashi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 285:22291-8. 2010
    ..These observations suggest that the LKB1-AMPK signaling axis in endothelial cells is a positive regulator of the revascularization response to tissue ischemia...
  27. pmc Thiazolidinediones reduce pathological neovascularization in ischemic retina via an adiponectin-dependent mechanism
    Akiko Higuchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany St, W611, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 30:46-53. 2010
    ..However, little is known about the effects of TZDs on retinal microvessel disorders...
  28. ncbi request reprint Akt/FOXO3a signaling modulates the endothelial stress response through regulation of heat shock protein 70 expression
    Hyo Soo Kim
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    FASEB J 19:1042-4. 2005
    ..Our results identify HSP70 as a new antiapoptotic target of Akt-FOXO3a signaling in endothelial cells that controls viability through modulation of the stress-induced intrinsic cell death pathway...
  29. pmc Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Med 11:1096-103. 2005
    ..These data suggest that adiponectin protects the heart from ischemia-reperfusion injury through both AMPK- and COX-2-dependent mechanisms...
  30. pmc Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart
    Yuichi Oshima
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University Medical School, 700 Albany St, W611, Boston, MA 02118, USA
    Circulation 117:3099-108. 2008
    ..To identify factors with novel therapeutic applications in cardiac diseases, we focused on the identification of factors secreted from Akt1-activated cells that have cardioprotective effects through autocrine/paracrine mechanisms...
  31. pmc Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload
    Masayuki Shimano
    Whitaker Cardiovascular Institute, Boston University, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 108:E899-906. 2011
    ....
  32. pmc Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model
    Tamar Aprahamian
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 177:3028-34. 2006
    ..apoE-/- model. Thus, the anti-inflammatory activities of statins may have utility for the treatment of both autoimmunity and atherosclerosis in patients with systemic lupus erythematosus...
  33. ncbi request reprint Akt3 overexpression in the heart results in progression from adaptive to maladaptive hypertrophy
    Yoshiaki Taniyama
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    J Mol Cell Cardiol 38:375-85. 2005
    ..However, continuous overexpression of Akt3 results in contractile dysfunction and increased susceptibility to cardiac injury. Thus, sustained activation of Akt signaling results in progression from adaptive to maladaptive hypertrophy...
  34. ncbi request reprint Endothelial overexpression of Fas ligand decreases atherosclerosis in apolipoprotein E-deficient mice
    Jiang Yang
    Department of Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118 2526, USA
    Arterioscler Thromb Vasc Biol 24:1466-73. 2004
    ..Fas ligand (FasL) can induce apoptosis in cells bearing the Fas receptor. The role of FasL in the vasculature with regard to atherosclerosis is controversial. This study examined the function of endothelial FasL during atherosclerosis...
  35. pmc DIP2A functions as a FSTL1 receptor
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 285:7127-34. 2010
    ..These data indicate that DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1...
  36. pmc Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2
    Kyriakos N Papanicolaou
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Mol Cell Cardiol 49:196-209. 2010
    ..In conclusion, our animal-based analyses together with the cell-based observations portray a limited role of cardiomyocyte-produced Cox-2 at baseline and in the context of ischemic or hemodynamic challenge...
  37. ncbi request reprint Akt signaling regulates side population cell phenotype via Bcrp1 translocation
    Masaki Mogi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 278:39068-75. 2003
    ..These data suggest that Akt signaling modulates the SP cell phenotype by regulating the expression of Bcrp1...
  38. pmc The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin
    Tamar Aprahamian
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 182:340-6. 2009
    ..These experiments suggest that PPARgamma agonists may be useful agents for the treatment of SLE. They also demonstrate that induction of adiponectin is a major mechanism underlying the immunomodulatory effects of PPARgamma agonists...
  39. pmc Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies
    Yukihiro Takemura
    Molecular Cardiology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Invest 117:375-86. 2007
    ..We propose that adiponectin protects the organism from systemic inflammation by promoting the clearance of early apoptotic cells by macrophages through a receptor-dependent pathway involving calreticulin...
  40. pmc Cardiac myocyte-specific ablation of follistatin-like 3 attenuates stress-induced myocardial hypertrophy
    Masayuki Shimano
    Whitaker Cardiovascular Institute, Boston University Medical Campus, Boston, Massachusetts 02118, USA
    J Biol Chem 286:9840-8. 2011
    ..These findings identify Fstl3 as a stress-induced regulator of hypertrophy that controls myocyte size via regulation of Smad signaling...
  41. pmc Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction
    Gennaro Galasso
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Circ Res 98:254-61. 2006
    ..These data suggest that EPC dysfunction is a mechanism by which elevated levels of ROS can contribute to vascular disease...
  42. ncbi request reprint Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    Cardiovasc Res 74:471-9. 2007
    ..This study investigated the expression and myocardial accumulation of adiponectin in a murine model of ischemia-reperfusion injury...
  43. ncbi request reprint Intraneuronal beta-amyloid expression downregulates the Akt survival pathway and blunts the stress response
    Jordi Magrane
    Department of Neurology, Caritas Saint Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Neurosci 25:10960-9. 2005
    ..These results suggest that the early dysfunction associated with intraneuronal Abeta accumulation in AD involve the associated impairments of Akt signaling and suppression of the stress response...
  44. pmc Short-term akt activation in cardiac muscle cells improves contractile function in failing hearts
    Ichiro Shiojima
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Am J Pathol 181:1969-76. 2012
    ..This beneficial effect of Akt on contractility is hypertrophy-independent and may be mediated in part by inhibition of cell death associated with heart failure...
  45. pmc Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy
    Marco Sandri
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 117:399-412. 2004
    ..Thus, forkhead factor(s) play a critical role in the development of muscle atrophy, and inhibition of Foxo factors is an attractive approach to combat muscle wasting...
  46. pmc Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype
    Koji Ohashi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 285:6153-60. 2010
    ....
  47. pmc Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2
    Sarah A McCalmon
    Department of Biology, Boston University, 24 Cummington st, Boston, MA 02215, USA
    Circ Res 106:952-60. 2010
    ..The vasoactive peptide angiotensin II (Ang II) is a potent cardiotoxic hormone whose actions have been well studied, yet questions remain pertaining to the downstream factors that mediate its effects in cardiomyocytes...
  48. ncbi request reprint Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart
    Suzanne Kovacic
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118 2256, USA
    J Biol Chem 278:39422-7. 2003
    ..In addition, our data suggest that the ability of insulin to inhibit AMPK may be controlled via an Akt-mediated mechanism...
  49. pmc Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation
    Jason M Konter
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 188:854-63. 2012
    ..g., obesity) predispose to development of ALI through exaggerated inflammatory response in pulmonary vascular endothelium...
  50. pmc Mitofusins are required for angiogenic function and modulate different signaling pathways in cultured endothelial cells
    Jesse J Lugus
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Mol Cell Cardiol 51:885-93. 2011
    ..Taken together, our data indicate that mitochondrial dynamics, particularly those mediated by the mitofusins, play a role in endothelial cell function and viability...
  51. pmc Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice
    Yanli Song
    Cardiovascular Division, Dept of Medicine, Brigham and Women s Hosiptal and Harvard Medical School, 77 Ave Louis Pasteur, NRB 630, Boston, MA 02115, USA
    Am J Physiol Heart Circ Physiol 295:H677-90. 2008
    ..Greater endothelial injury and an enhanced inflammatory response could be the underlying causes of the sensitivity and may work in concert with BMPR2 heterozygosity to promote the development of persistent pulmonary hypertension...
  52. pmc Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
    Yu Li
    Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, 02118, USA
    FASEB J 25:1664-79. 2011
    ....
  53. pmc Cyclooxygenase-2 induction by adiponectin is regulated by a sphingosine kinase-1 dependent mechanism in cardiac myocytes
    Yasumasa Ikeda
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    FEBS Lett 582:1147-50. 2008
    ..These findings suggest that APN is a physiological regulator of COX-2 signaling in the heart and that this regulation occurs in part via a SphK-1-S1P receptor dependent mechanism in cardiac myocytes...
  54. ncbi request reprint The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity
    Edward F Rocnik
    Molecular Cardiology, Whitaker Cardiovascular Institute and Department of Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 281:22855-64. 2006
    ..Basic fibroblast growth factor and SMOC-2 elicited a synergistic effect on cell invasion. Taken together, our results demonstrate that SMOC-2 is a novel angiogenic factor that potentiates angiogenic effects of growth factors...
  55. pmc Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart
    Kyriakos N Papanicolaou
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Circ Res 111:1012-26. 2012
    ..Mitofusins (Mfn-1 and Mfn-2) are known regulators of mitochondrial networks, but their role during perinatal maturation of the heart has yet to be examined...
  56. pmc Loss of mitofusin 2 promotes endoplasmic reticulum stress
    Gladys A Ngoh
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 287:20321-32. 2012
    ..We conclude that Mfn2 but not Mfn1 is an ER stress-inducible protein that is required for the proper temporal sequence of the ER stress response...
  57. pmc Insulin-like 6 is induced by muscle injury and functions as a regenerative factor
    Ling Zeng
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University Medical Campus, Boston, Massachusetts 02118, USA
    J Biol Chem 285:36060-9. 2010
    ..Conversely, knockdown of Insl6 reduced proliferation and increased apoptosis. These data indicate that Insl6 is an injury-regulated myokine that functions as a myogenic regenerative factor...
  58. ncbi request reprint HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cells
    Adriane Skaletz-Rorowski
    Division of Cardiovascular Research, St Elizabeth s Medical Center of Boston, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA
    Cardiovasc Res 57:253-64. 2003
    ..This pathway is critical for cellular responses that contribute to angiogenesis and EC function including nitric oxide production, cellular survival and migration...
  59. ncbi request reprint AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells
    Mengwei Zang
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:47898-905. 2004
    ..Metformin lowers hepatic lipid content by activating AMPK, thereby mediating beneficial effects in hyperglycemia and insulin resistance...
  60. ncbi request reprint MRI-guided ultrasonic heating allows spatial control of exogenous luciferase in canine prostate
    Christina E Silcox
    Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 31:965-70. 2005
    ..This study demonstrates the feasibility of using ultrasonic heating to control transgene expression spatially using a minimally-invasive approach...
  61. pmc T-cadherin is essential for adiponectin-mediated revascularization
    Jennifer L Parker-Duffen
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 288:24886-97. 2013
    ..These data highlight a previously unrecognized role for T-cadherin in limb revascularization and show that it is essential for mediating the vascular actions of adiponectin. ..
  62. ncbi request reprint Akt signaling mediates VEGF/VPF vascular permeability in vivo
    Isabelle Six
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118 2526, USA
    FEBS Lett 532:67-9. 2002
    ..This Akt-mediated increase in vascular permeability was inhibited by the eNOS inhibitor L-NAME. These data show that Akt signaling is both necessary and sufficient for vascular permeability in an in vivo model...
  63. ncbi request reprint Adiponectin and cardiovascular inflammatory responses
    Yukihiro Takemura
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Curr Atheroscler Rep 9:238-43. 2007
    ..This review focuses on the anti-inflammatory properties of adiponectin in various experimental systems, especially with respect to cardiovascular diseases...
  64. ncbi request reprint Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway
    Ichiro Shiojima
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Genes Dev 20:3347-65. 2006
    ..How this signaling pathway contributes to the development of physiological/pathological hypertrophy and heart failure will also be discussed...
  65. ncbi request reprint Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism
    Toshimitsu Suhara
    Divisions of Neurology and Cardiovascular Research, St Elizabeth s Medical Center, Tufts University, Boston, MA 02135, USA
    Neurobiol Aging 24:437-51. 2003
    ..We conclude that intracellular production of Abeta42 is cytotoxic to endothelial cells and that disruption of the Akt/GSK-3beta cell signaling pathway is involved...
  66. ncbi request reprint AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress
    Daisuke Nagata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 278:31000-6. 2003
    ..As such, endothelial AMPK signaling may be a critical determinant of blood vessel recruitment to tissues that are subjected to ischemic stress...
  67. ncbi request reprint Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons
    Jordi Magrane
    Division of Neurology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Neurosci 24:1700-6. 2004
    ..Together, these results implicate the cellular stress response as a possible modulator of Abeta-induced toxicity in neuronal cultures...
  68. pmc Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin
    Thuy L Phung
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Cell 10:159-70. 2006
    ..Akt signaling in the tumor vascular stroma was sensitive to rapamycin, suggesting that rapamycin may affect tumor growth in part by acting as a vascular Akt inhibitor...
  69. ncbi request reprint Angiotensin II induces myocyte enhancer factor 2- and calcineurin/nuclear factor of activated T cell-dependent transcriptional activation in vascular myocytes
    Etsu Suzuki
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Circ Res 90:1004-11. 2002
    ..These results suggest that Ang II stimulates the MEF2- and calcineurin/NFAT-dependent pathways and that these pathways have distinct roles in VSMCs...
  70. ncbi request reprint Angiopoietin-1 negatively regulates expression and activity of tissue factor in endothelial cells
    Injune Kim
    National Creative Research Initiatives Center for Endothelial Cells and Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea
    FASEB J 16:126-8. 2002
    ..Ang1 may be useful as an inhibitor of VEGF- and TNF-a-induced coagulation, inflammation, and cancer progression...
  71. ncbi request reprint Evidence for adipose-muscle cross talk: opposing regulation of muscle proteolysis by adiponectin and Fatty acids
    Qiugen Zhou
    Renal Division, Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, WMB 338, Atlanta, GA 30322, USA
    Endocrinology 148:5696-705. 2007
    ..We conclude that the balance between free fatty acids and adiponectin impacts muscle proteolysis in insulin-resistant conditions and suggest a role for adipose tissue-muscle cross talk in diabetes and obesity...
  72. ncbi request reprint Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A
    Yong Chool Boo
    Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 277:3388-96. 2002
    ..A coordinated interaction between Akt and PKA may be an important mechanism by which eNOS activity is regulated in response to physiological stimuli such as shear stress...
  73. pmc Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation
    Toshimitsu Suhara
    Division of Cardiovascular Research, St Elizabeth s Medical Center of Boston, Massachusetts 02135, USA
    Mol Cell Biol 22:680-91. 2002
    ....
  74. ncbi request reprint Spatial and temporal control of transgene expression through ultrasound-mediated induction of the heat shock protein 70B promoter in vivo
    Roy C Smith
    Molecular Cardiology CVI, Whitaker Cardiovascular Institute, Boston University School of Medicine, 75 Albany Street, W611, Boston, MA 02118, USA
    Hum Gene Ther 13:697-706. 2002
    ..These data demonstrate that combining the inducible hsp70B promoter with ultrasound induction allows safe local expression of cytotoxic genes with possible therapeutic utility...
  75. ncbi request reprint Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase
    Ming Hui Zou
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 277:32552-7. 2002
    ..We conclude that ONOO(-) inhibits Akt and increases AMPK-dependent Ser(1179) phosphorylation of eNOS resulting in enhanced O(2)() release...
  76. ncbi request reprint Activated forkhead transcription factor inhibits neointimal hyperplasia after angioplasty through induction of p27
    Kyung Woo Park
    Cardiovascular Laboratory, Clinical Research Institute, Seoul National University Hospital, Korea
    Arterioscler Thromb Vasc Biol 25:742-7. 2005
    ..Furthermore, we tested whether FKHRL1 overexpression can inhibit neointimal hyperplasia in a rat carotid artery model...
  77. ncbi request reprint Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61, leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia
    Hae Young Lee
    National Research Laboratory for Cardiovascular Stem Cell, Seoul National University Hospital, Korea
    Circ Res 100:372-80. 2007
    ..These data suggest that FOXO3a is a negative transcription factor of CYR61 and that suppression of CYR61 is among several mechanisms by which FOXO3a inhibits VSMC proliferation and neointimal hyperplasia...
  78. ncbi request reprint PKCalpha activates eNOS and increases arterial blood flow in vivo
    Chohreh Partovian
    Angiogenesis Research Center, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Circ Res 97:482-7. 2005
    ..In conclusion, these data demonstrate for the first time that PKCalpha stimulates NO production in endothelial cells and plays a role in regulation of blood flow in vivo...
  79. ncbi request reprint Control of vascular cell differentiation by homeobox transcription factors
    David H Gorski
    Division of Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University, Boston, MA, USA
    Trends Cardiovasc Med 13:213-20. 2003
    ....