Affiliation: Tufts University
- The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear systemDouglas E Vetter
Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 104:20594-9. 2007..Moreover, alpha10 nAChR subunits are required for normal olivocochlear activity because alpha9 homomeric nAChRs do not support maintenance of normal olivocochlear innervation or function in alpha10(-/-) mutant mice...
- SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cellsVidya Murthy
Dept of Neuroscience, Tufts Univ School of Medicine, 136 Harrison Ave Boston, MA 02111, USA
Mol Cell Neurosci 40:39-49. 2009..The data suggest a hierarchy of activity necessary to maintain early olivocochlear synapses at their targets, with SK2 serving an epistatic, upstream, role to the nAChRs...
- Activity of nAChRs containing alpha9 subunits modulates synapse stabilization via bidirectional signaling programsVidya Murthy
Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA
Dev Neurobiol 69:931-49. 2009..Finally, by using mice expressing the nondesensitizing alpha9 L9'T point mutant nAChR subunit, we show that increased nAChR activity drives synaptic hyperinnervation...
- Olivocochlear neuron central anatomy is normal in alpha 9 knockout miceM Christian Brown
Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
J Assoc Res Otolaryngol 10:64-75. 2009....
- A novel effect of cochlear efferents: in vivo response enhancement does not require alpha9 cholinergic receptorsStephane F Maison
Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
J Neurophysiol 97:3269-78. 2007....
- A corticotropin-releasing factor system expressed in the cochlea modulates hearing sensitivity and protects against noise-induced hearing lossChristine E Graham
Tufts University School of Medicine, Department of Neuroscience, Boston, MA 02111, USA
Neurobiol Dis 38:246-58. 2010..Our data suggest that CRFR2 constitutively modulates hearing sensitivity under normal conditions, and thereby provides protection against noise-induced hearing loss...
- Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitabilityStephane F Maison
Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 30:6751-62. 2010....
- Essential role of retinoblastoma protein in mammalian hair cell development and hearingCyrille Sage
Neurology Service, Center for Nervous System Repair, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 103:7345-50. 2006....
- Multiplexed isobaric tagging protocols for quantitative mass spectrometry approaches to auditory researchDouglas E Vetter
Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA
Methods Mol Biol 493:345-66. 2009..These two topics are dependant upon one's resources, and where applicable, one's collaborators. We strongly encourage the reader to seek out expert advice on topics not covered here...
- Mouse outer hair cells lacking the alpha9 ACh receptor are motileDavid Z Z He
Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, NE 68175, USA
Brain Res Dev Brain Res 148:19-25. 2004..Results indicate that cochlear sensitivity, based on CAP thresholds, is similar for homozygous mutant and wild-type mice. Electromotility is also present in OHCs, independent of whether the alpha9 subunit is present or absent...
- Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypesVu Thuong Nguyen
Department of Dermatology, University of California, Davis, Sacramento, CA 95817, USA
Exp Cell Res 294:534-49. 2004..These findings may aid in the development of novel methods useful for the treatment of skin adhesion diseases and tumor metastasis...
- Central role of alpha9 acetylcholine receptor in coordinating keratinocyte adhesion and motility at the initiation of epithelializationAlex I Chernyavsky
Department of Dermatology, University of California Irvine, C340 Medical Sciences I, Irvine, CA 92697, USA
Exp Cell Res 313:3542-55. 2007..By activating alpha9 AChR, ACh can control the dynamics and strength of cell-cell cohesion, disabling of a trailing uropod and disassembly and reassembly of focal adhesions, thus facilitating crawling locomotion...
- Developmental regulation of nicotinic synapses on cochlear inner hair cellsEleonora Katz
Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas Universidad de Buenos Aires UBA, Argentina
J Neurosci 24:7814-20. 2004..Furthermore, this developmental knock-out of alpha10, but not alpha9, supports the hypothesis that functional nicotinic acetylcholine receptors in hair cells are heteromers containing both these subunits...
- Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasisJuan Arredondo
Department of Dermatology, University of California, Davis, 4860 Y Street, 3400, Sacramento, CA 95817, USA
Life Sci 72:2063-7. 2003..Taken together, these results suggest an important role for alpha7 nAChR in mediating plethoric effects of non-neuronal acetylcholine on cutaneous homeostasis...
- Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epitheliumJuan Arredondo
Department of Dermatology, UC Davis Medical Center, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA
J Cell Biol 159:325-36. 2002....
- The alpha9alpha10 nicotinic acetylcholine receptor is permeable to and is modulated by divalent cationsNoelia Weisstaub
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular CONICET UBA, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Hear Res 167:122-35. 2002..8 mM Ca(2+) (14.3 microM), suggesting that potentiation by Ca(2+) involves changes in the apparent affinity of the alpha 9 alpha 10 receptor for ACh...
- Urocortin-deficient mice show hearing impairment and increased anxiety-like behaviorDouglas E Vetter
The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nat Genet 31:363-9. 2002..These results provide the first example of a function for any peptidergic system in hearing...
- Investigations into the mouse olivocochlear systemDouglas Vetter; Fiscal Year: 2007..This will functionally link the urocortin hormone/CRH receptor and classical ACh neurotransmitter systems together in a unified model explaining inner ear based protection from noise induced hearing loss. ..