Douglas Vetter

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. pmc The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system
    Douglas E Vetter
    Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 104:20594-9. 2007
  2. pmc SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells
    Vidya Murthy
    Dept of Neuroscience, Tufts Univ School of Medicine, 136 Harrison Ave Boston, MA 02111, USA
    Mol Cell Neurosci 40:39-49. 2009
  3. pmc Activity of nAChRs containing alpha9 subunits modulates synapse stabilization via bidirectional signaling programs
    Vidya Murthy
    Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA
    Dev Neurobiol 69:931-49. 2009
  4. pmc Olivocochlear neuron central anatomy is normal in alpha 9 knockout mice
    M Christian Brown
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    J Assoc Res Otolaryngol 10:64-75. 2009
  5. ncbi A novel effect of cochlear efferents: in vivo response enhancement does not require alpha9 cholinergic receptors
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    J Neurophysiol 97:3269-78. 2007
  6. pmc A corticotropin-releasing factor system expressed in the cochlea modulates hearing sensitivity and protects against noise-induced hearing loss
    Christine E Graham
    Tufts University School of Medicine, Department of Neuroscience, Boston, MA 02111, USA
    Neurobiol Dis 38:246-58. 2010
  7. pmc Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 30:6751-62. 2010
  8. pmc Essential role of retinoblastoma protein in mammalian hair cell development and hearing
    Cyrille Sage
    Neurology Service, Center for Nervous System Repair, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:7345-50. 2006
  9. pmc Multiplexed isobaric tagging protocols for quantitative mass spectrometry approaches to auditory research
    Douglas E Vetter
    Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA
    Methods Mol Biol 493:345-66. 2009
  10. ncbi Mouse outer hair cells lacking the alpha9 ACh receptor are motile
    David Z Z He
    Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, NE 68175, USA
    Brain Res Dev Brain Res 148:19-25. 2004

Research Grants

Collaborators

Detail Information

Publications17

  1. pmc The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system
    Douglas E Vetter
    Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 104:20594-9. 2007
    ..Moreover, alpha10 nAChR subunits are required for normal olivocochlear activity because alpha9 homomeric nAChRs do not support maintenance of normal olivocochlear innervation or function in alpha10(-/-) mutant mice...
  2. pmc SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells
    Vidya Murthy
    Dept of Neuroscience, Tufts Univ School of Medicine, 136 Harrison Ave Boston, MA 02111, USA
    Mol Cell Neurosci 40:39-49. 2009
    ..The data suggest a hierarchy of activity necessary to maintain early olivocochlear synapses at their targets, with SK2 serving an epistatic, upstream, role to the nAChRs...
  3. pmc Activity of nAChRs containing alpha9 subunits modulates synapse stabilization via bidirectional signaling programs
    Vidya Murthy
    Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA
    Dev Neurobiol 69:931-49. 2009
    ..Finally, by using mice expressing the nondesensitizing alpha9 L9'T point mutant nAChR subunit, we show that increased nAChR activity drives synaptic hyperinnervation...
  4. pmc Olivocochlear neuron central anatomy is normal in alpha 9 knockout mice
    M Christian Brown
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    J Assoc Res Otolaryngol 10:64-75. 2009
    ....
  5. ncbi A novel effect of cochlear efferents: in vivo response enhancement does not require alpha9 cholinergic receptors
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    J Neurophysiol 97:3269-78. 2007
    ....
  6. pmc A corticotropin-releasing factor system expressed in the cochlea modulates hearing sensitivity and protects against noise-induced hearing loss
    Christine E Graham
    Tufts University School of Medicine, Department of Neuroscience, Boston, MA 02111, USA
    Neurobiol Dis 38:246-58. 2010
    ..Our data suggest that CRFR2 constitutively modulates hearing sensitivity under normal conditions, and thereby provides protection against noise-induced hearing loss...
  7. pmc Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 30:6751-62. 2010
    ....
  8. pmc Essential role of retinoblastoma protein in mammalian hair cell development and hearing
    Cyrille Sage
    Neurology Service, Center for Nervous System Repair, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:7345-50. 2006
    ....
  9. pmc Multiplexed isobaric tagging protocols for quantitative mass spectrometry approaches to auditory research
    Douglas E Vetter
    Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA
    Methods Mol Biol 493:345-66. 2009
    ..These two topics are dependant upon one's resources, and where applicable, one's collaborators. We strongly encourage the reader to seek out expert advice on topics not covered here...
  10. ncbi Mouse outer hair cells lacking the alpha9 ACh receptor are motile
    David Z Z He
    Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, NE 68175, USA
    Brain Res Dev Brain Res 148:19-25. 2004
    ..Results indicate that cochlear sensitivity, based on CAP thresholds, is similar for homozygous mutant and wild-type mice. Electromotility is also present in OHCs, independent of whether the alpha9 subunit is present or absent...
  11. ncbi Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes
    Vu Thuong Nguyen
    Department of Dermatology, University of California, Davis, Sacramento, CA 95817, USA
    Exp Cell Res 294:534-49. 2004
    ..These findings may aid in the development of novel methods useful for the treatment of skin adhesion diseases and tumor metastasis...
  12. pmc Central role of alpha9 acetylcholine receptor in coordinating keratinocyte adhesion and motility at the initiation of epithelialization
    Alex I Chernyavsky
    Department of Dermatology, University of California Irvine, C340 Medical Sciences I, Irvine, CA 92697, USA
    Exp Cell Res 313:3542-55. 2007
    ..By activating alpha9 AChR, ACh can control the dynamics and strength of cell-cell cohesion, disabling of a trailing uropod and disassembly and reassembly of focal adhesions, thus facilitating crawling locomotion...
  13. ncbi Developmental regulation of nicotinic synapses on cochlear inner hair cells
    Eleonora Katz
    Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas Universidad de Buenos Aires UBA, Argentina
    J Neurosci 24:7814-20. 2004
    ..Furthermore, this developmental knock-out of alpha10, but not alpha9, supports the hypothesis that functional nicotinic acetylcholine receptors in hair cells are heteromers containing both these subunits...
  14. ncbi Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis
    Juan Arredondo
    Department of Dermatology, University of California, Davis, 4860 Y Street, 3400, Sacramento, CA 95817, USA
    Life Sci 72:2063-7. 2003
    ..Taken together, these results suggest an important role for alpha7 nAChR in mediating plethoric effects of non-neuronal acetylcholine on cutaneous homeostasis...
  15. pmc Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium
    Juan Arredondo
    Department of Dermatology, UC Davis Medical Center, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA
    J Cell Biol 159:325-36. 2002
    ....
  16. ncbi The alpha9alpha10 nicotinic acetylcholine receptor is permeable to and is modulated by divalent cations
    Noelia Weisstaub
    Instituto de Investigaciones en Ingeniería Genética y Biología Molecular CONICET UBA, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
    Hear Res 167:122-35. 2002
    ..8 mM Ca(2+) (14.3 microM), suggesting that potentiation by Ca(2+) involves changes in the apparent affinity of the alpha 9 alpha 10 receptor for ACh...
  17. ncbi Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior
    Douglas E Vetter
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Genet 31:363-9. 2002
    ..These results provide the first example of a function for any peptidergic system in hearing...

Research Grants5

  1. Investigations into the mouse olivocochlear system
    Douglas Vetter; Fiscal Year: 2007
    ..This will functionally link the urocortin hormone/CRH receptor and classical ACh neurotransmitter systems together in a unified model explaining inner ear based protection from noise induced hearing loss. ..