Laura N Vandenberg

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of bisphenol A
    Beverly S Rubin
    Tufts University, School of Medicine, Boston, Massachusetts 02111, USA
    Endocrinology 147:3681-91. 2006
  2. doi request reprint Human exposures to bisphenol A: mismatches between data and assumptions
    Laura N Vandenberg
    Center for Regenerative and Developmental Biology, Tufts University, Medford, MA 02155, USA
    Rev Environ Health 28:37-58. 2013
  3. pmc Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology
    Laura N Vandenberg
    Center for Regenerative and Developmental Biology, and Department of Biology, Tufts University, Medford, MA, United States
    Reprod Toxicol 38:1-15. 2013
  4. pmc Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
    Laura N Vandenberg
    Tufts University, Center for Regenerative and Developmental Biology, Department of Biology, 200 Boston Avenue, Suite 4600, Medford, Massachusetts 02155, USA
    Endocr Rev 33:378-455. 2012
  5. ncbi request reprint Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A
    Laura N Vandenberg
    Tufts Center for Regenerative and Developmental Biology, Department of Biology, Tufts University, Medford, MA 02155, USA
    Cien Saude Colet 17:407-34. 2012
  6. ncbi request reprint Human exposure to bisphenol A (BPA)
    Laura N Vandenberg
    Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, 136 Harrison Avenue, Boston, MA 02111, USA
    Reprod Toxicol 24:139-77. 2007
  7. pmc Biomonitoring studies should be used by regulatory agencies to assess human exposure levels and safety of bisphenol A
    Laura N Vandenberg
    Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts, USA
    Environ Health Perspect 118:1051-4. 2010
  8. pmc Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, Massachusetts 02111, USA
    Endocrinology 148:116-27. 2007
  9. pmc Perinatal bisphenol A exposure increases estrogen sensitivity of the mammary gland in diverse mouse strains
    Perinaaz R Wadia
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Environ Health Perspect 115:592-8. 2007
  10. pmc Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A
    Laura N Vandenberg
    Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts, USA
    Environ Health Perspect 118:1055-70. 2010

Detail Information

Publications23

  1. ncbi request reprint Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of bisphenol A
    Beverly S Rubin
    Tufts University, School of Medicine, Boston, Massachusetts 02111, USA
    Endocrinology 147:3681-91. 2006
    ..These data indicate that BPA may be capable of altering important events during critical periods of brain development...
  2. doi request reprint Human exposures to bisphenol A: mismatches between data and assumptions
    Laura N Vandenberg
    Center for Regenerative and Developmental Biology, Tufts University, Medford, MA 02155, USA
    Rev Environ Health 28:37-58. 2013
    ..Our conclusions are consistent with the large number of hazards and adverse effects identified in laboratory animals exposed to low doses of BPA...
  3. pmc Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology
    Laura N Vandenberg
    Center for Regenerative and Developmental Biology, and Department of Biology, Tufts University, Medford, MA, United States
    Reprod Toxicol 38:1-15. 2013
    ..This discussion should result in a better understanding of these issues, and allow for additional dialog on their impact on risk assessment...
  4. pmc Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
    Laura N Vandenberg
    Tufts University, Center for Regenerative and Developmental Biology, Department of Biology, 200 Boston Avenue, Suite 4600, Medford, Massachusetts 02155, USA
    Endocr Rev 33:378-455. 2012
    ..Thus, fundamental changes in chemical testing and safety determination are needed to protect human health...
  5. ncbi request reprint Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A
    Laura N Vandenberg
    Tufts Center for Regenerative and Developmental Biology, Department of Biology, Tufts University, Medford, MA 02155, USA
    Cien Saude Colet 17:407-34. 2012
    ..The two toxicokinetic studies that suggested human BPA exposure is negligible have significant deficiencies, are directly contradicted by hypothesis-driven studies, and are therefore not reliable for risk assessment purposes...
  6. ncbi request reprint Human exposure to bisphenol A (BPA)
    Laura N Vandenberg
    Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, 136 Harrison Avenue, Boston, MA 02111, USA
    Reprod Toxicol 24:139-77. 2007
    ..The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models...
  7. pmc Biomonitoring studies should be used by regulatory agencies to assess human exposure levels and safety of bisphenol A
    Laura N Vandenberg
    Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts, USA
    Environ Health Perspect 118:1051-4. 2010
    ..Within the past 3 years, four major evaluations of bisphenol A (BPA) safety have been undertaken. However, these assessments have arrived at quite different conclusions regarding the safety of BPA at current human exposure levels...
  8. pmc Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, Massachusetts 02111, USA
    Endocrinology 148:116-27. 2007
    ..These results suggest that alterations in mammary gland phenotypes observed at puberty and adulthood in perinatally exposed mice have their origins in fetal development...
  9. pmc Perinatal bisphenol A exposure increases estrogen sensitivity of the mammary gland in diverse mouse strains
    Perinaaz R Wadia
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Environ Health Perspect 115:592-8. 2007
    ..Future studies to assess the role of estrogen receptors as mediators of BPA action require estrogen receptor knock-out mice that were generated on a C57Bl6 background. The sensitivity of the C57Bl6 strain to estradiol and BPA is unknown...
  10. pmc Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A
    Laura N Vandenberg
    Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts, USA
    Environ Health Perspect 118:1055-70. 2010
    ..Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. Importantly, results from a large number of biomonitoring studies are at odds with the results from two toxicokinetic studies...
  11. pmc Does breast cancer start in the womb?
    Ana M Soto
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA
    Basic Clin Pharmacol Toxicol 102:125-33. 2008
    ..Hence, both animal experiments and epidemiological data strengthen the hypothesis that foetal exposure to xenooestrogens may be an underlying cause of the increased incidence of breast cancer observed over the last 50 years...
  12. pmc Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 mice
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Ave, Boston, MA 02111, United States
    Reprod Toxicol 26:210-9. 2008
    ..Similar structures have also been observed following exposure to other estrogens. These results are further evidence that perinatal BPA exposure can alter the morphology of the rodent mammary gland in adulthood...
  13. pmc Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Endocr Rev 30:75-95. 2009
    ....
  14. doi request reprint Rab GTPases are required for early orientation of the left-right axis in Xenopus
    Laura N Vandenberg
    Center for Regenerative and Developmental Biology, and Biology Department, Tufts University Medford, MA 02155, USA
    Mech Dev 130:254-71. 2013
    ..We conclude that Rab11-mediated transport is responsible for the movement of cargo within early blastomeres, and that Rab11 expression is required throughout the early embryo for proper LR patterning...
  15. pmc The male mammary gland: a target for the xenoestrogen bisphenol A
    Laura N Vandenberg
    Tufts University, Department of Biology, and Center for Regenerative and Developmental Biology, 200 Boston Avenue, Suite 4600, Medford, MA 02155, United States
    Reprod Toxicol 37:15-23. 2013
    ..These results may provide insight into gynecomastia, the most common male breast disease in humans, where proliferation of the mammary epithelium leads to breast enlargement...
  16. pmc A unified model for left-right asymmetry? Comparison and synthesis of molecular models of embryonic laterality
    Laura N Vandenberg
    Center for Regenerative and Developmental Biology, and Biology Department, Tufts University, Medford, MA 02155, USA
    Dev Biol 379:1-15. 2013
    ....
  17. pmc Serotonin has early, cilia-independent roles in Xenopus left-right patterning
    Laura N Vandenberg
    Center for Regenerative and Developmental Biology and Department of Biology, Tufts University, 200 Boston Avenue, Suite 4600, Medford, MA 02155, USA
    Dis Model Mech 6:261-8. 2013
    ..The results uniformly support a role for serotonin in the cleavage-stage embryo, long before the appearance of cilia, in ventral right blastomeres that do not contribute to the ciliated organ...
  18. pmc Low frequency vibrations induce malformations in two aquatic species in a frequency-, waveform-, and direction-specific manner
    Laura N Vandenberg
    Biology Department, Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts, USA
    PLoS ONE 7:e51473. 2012
    ..The results of this study support the conclusion that low frequency vibrations are toxic to aquatic vertebrates, with detrimental effects observed in two important model species with very different embryonic architectures...
  19. ncbi request reprint The mammary gland response to estradiol: monotonic at the cellular level, non-monotonic at the tissue-level of organization?
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, MA 02111, USA
    J Steroid Biochem Mol Biol 101:263-74. 2006
    ..This non-monotonic dose-response in the mammary gland may reflect complex interactions, where estrogen can act on multiple targets either as an agonist or antagonist...
  20. pmc Normalized shape and location of perturbed craniofacial structures in the Xenopus tadpole reveal an innate ability to achieve correct morphology
    Laura N Vandenberg
    Center for Regenerative and Developmental Biology, and Biology Department, Tufts University, Medford, MA 02155, USA
    Dev Dyn 241:863-78. 2012
    ....
  21. pmc Neurally Derived Tissues in Xenopus laevis Embryos Exhibit a Consistent Bioelectrical Left-Right Asymmetry
    Vaibhav P Pai
    Department of Biology and Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, MA 02155, USA
    Stem Cells Int 2012:353491. 2012
    ..These data suggest that even anatomically symmetrical structures may possess subtle but consistent laterality and interact with other developmental left-right patterning pathways...
  22. pmc Polarity proteins are required for left-right axis orientation and twin-twin instruction
    Laura N Vandenberg
    Department of Biology, Center for Regenerative and Developmental Biology, Tufts University, Medford, MA 02155, USA
    Genesis 50:219-34. 2012
    ..genesis 50:219-234, 2012. © 2011 Wiley Periodicals, Inc...
  23. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007