Theoharis Theoharides

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Dietary interventions for atopic disorders
    Despoina Mavrommati
    Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, 136 Harrison Avenue, Suite J304, Boston, MA 02111, USA
    Curr Pharm Des 20:996-1002. 2014
  2. doi request reprint The "missing link" in autoimmunity and autism: extracellular mitochondrial components secreted from activated live mast cells
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, USA Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, USA Department of Internal Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, USA Department of Psychiatry, Tufts University School of Medicine, Tufts Medical Center, 136 Harrison Avenue, Boston, MA, USA Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA Electronic address
    Autoimmun Rev 12:1136-42. 2013
  3. doi request reprint Is a subtype of autism an allergy of the brain?
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, MA 02111, USA
    Clin Ther 35:584-91. 2013
  4. pmc Focal brain inflammation and autism
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Suite J304, 136 Harrison Avenue, Boston, MA 02111, USA
    J Neuroinflammation 10:46. 2013
  5. pmc Perinatal stress, brain inflammation and risk of autism-review and proposal
    Asimenia Angelidou
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine and Tufts Medical Center, Boston, MA 02111, USA
    BMC Pediatr 12:89. 2012
  6. doi request reprint Contribution of stress to asthma worsening through mast cell activation
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Tufts Medical Center, Boston, MA 02111, USA
    Ann Allergy Asthma Immunol 109:14-9. 2012
  7. doi request reprint Is nasal saline irrigation all it is cracked up to be?
    Reena Khianey
    UMDNJ NJMS, Newark, NJ 07103, USA
    Ann Allergy Asthma Immunol 109:20-8. 2012
  8. pmc Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin
    Shahrzad Asadi
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Neuroinflammation 9:85. 2012
  9. ncbi request reprint Mast cells in allergic and inflammatory diseases
    Nikolaos Sismanopoulos
    Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, MA 02111, USA
    Curr Pharm Des 18:2261-77. 2012
  10. doi request reprint Mast cell activation and autism
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
    Biochim Biophys Acta 1822:34-41. 2012

Research Grants

  1. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis C Theoharides; Fiscal Year: 2010
  2. Stress Induces Skin Mast Cell Activation & Vasodilation
    Theoharis Theoharides; Fiscal Year: 2005
  3. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
  4. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
  5. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis Theoharides; Fiscal Year: 2007
  6. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis Theoharides; Fiscal Year: 2009
  7. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
  8. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2010

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Dietary interventions for atopic disorders
    Despoina Mavrommati
    Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, 136 Harrison Avenue, Suite J304, Boston, MA 02111, USA
    Curr Pharm Des 20:996-1002. 2014
    ..The basis of such use has evolved from clinical anecdotal observations over time, to a growing number of in vitro and some in vivo studies that support the use of some of these compounds, especially select flavonoids. ..
  2. doi request reprint The "missing link" in autoimmunity and autism: extracellular mitochondrial components secreted from activated live mast cells
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, USA Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, USA Department of Internal Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, USA Department of Psychiatry, Tufts University School of Medicine, Tufts Medical Center, 136 Harrison Avenue, Boston, MA, USA Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA Electronic address
    Autoimmun Rev 12:1136-42. 2013
    ..Blocking the secretion of extracellular mitochondrial components could present unique possibilities for the therapy of ASD and other autoimmune diseases. Unique formulation of the flavonoid luteolin offers unique advantages. ..
  3. doi request reprint Is a subtype of autism an allergy of the brain?
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, MA 02111, USA
    Clin Ther 35:584-91. 2013
    ..Perinatal stress and environmental factors appear to play a significant role in increasing the risk for ASDs. There is no definitive pathogenesis, which therefore significantly hinders the development of a cure...
  4. pmc Focal brain inflammation and autism
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Suite J304, 136 Harrison Avenue, Boston, MA 02111, USA
    J Neuroinflammation 10:46. 2013
    ..The natural flavonoid luteolin inhibits mTOR, mast cells and microglia and could have a significant benefit in ASD...
  5. pmc Perinatal stress, brain inflammation and risk of autism-review and proposal
    Asimenia Angelidou
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine and Tufts Medical Center, Boston, MA 02111, USA
    BMC Pediatr 12:89. 2012
    ..Many autism "susceptibility" genes have been identified, but "environmental" factors appear to play a significant role. Increasing evidence suggests that there are different ASD endophenotypes...
  6. doi request reprint Contribution of stress to asthma worsening through mast cell activation
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Tufts Medical Center, Boston, MA 02111, USA
    Ann Allergy Asthma Immunol 109:14-9. 2012
    ..To review the available evidence linking stress to asthma and to investigate whether mast cells contribute to the effect of stress through activation by corticotropin-releasing hormone (CRH)...
  7. doi request reprint Is nasal saline irrigation all it is cracked up to be?
    Reena Khianey
    UMDNJ NJMS, Newark, NJ 07103, USA
    Ann Allergy Asthma Immunol 109:20-8. 2012
    ..This review examines the literature regarding nasal saline irrigation in the management of sinonasal disease. We explore the various properties of nasal irrigation solutions and their effects on nasal symptoms...
  8. pmc Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin
    Shahrzad Asadi
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Neuroinflammation 9:85. 2012
    ....
  9. ncbi request reprint Mast cells in allergic and inflammatory diseases
    Nikolaos Sismanopoulos
    Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, MA 02111, USA
    Curr Pharm Des 18:2261-77. 2012
    ..Better understanding of these two processes and how mast cells exert both immunostimulatory and immunosuppressive actions could lead to the development of inhibitors of release of specific mediators with novel therapeutic applications...
  10. doi request reprint Mast cell activation and autism
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
    Biochim Biophys Acta 1822:34-41. 2012
    ..This article is part of a Special Issue entitled: Mast cells in inflammation...
  11. pmc Mast cells and inflammation
    Theoharis C Theoharides
    Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, MA 02111, USA
    Biochim Biophys Acta 1822:21-33. 2012
    ..Unraveling selective mast cell secretion could also help develop unique mast cell inhibitors with novel therapeutic applications. This article is part of a Special Issue entitled: Mast cells in inflammation...
  12. pmc Neuro-inflammation, blood-brain barrier, seizures and autism
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, USA
    J Neuroinflammation 8:168. 2011
    ..Treating neuro-inflammation may be useful when anti-seizure medications are ineffective...
  13. pmc Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children
    Bodi Zhang
    Laboratory of Molecular Immunopharmacology and Drug Discovery, Tufts University School of Medicine, Boston, MA, USA
    J Neuroinflammation 7:80. 2010
    ..001) as compared to normally developing, unrelated controls (n = 12). Extracellular blood mtDNA and other components may characterize an autistic endophenotype and may contribute to its pathogenesis by activating autoimmune responses...
  14. pmc Neurotensin is increased in serum of young children with autistic disorder
    Asimenia Angelidou
    Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA, USA
    J Neuroinflammation 7:48. 2010
    ..004). There was no statistically significant difference in the serum levels of β-endorphin or substance P (SP). NT could stimulate immune cells, especially mast cells, and/or have direct effects on brain inflammation and ASD...
  15. pmc Mercury induces inflammatory mediator release from human mast cells
    Duraisamy Kempuraj
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts Medical Center, Boston, MA 02111, USA
    J Neuroinflammation 7:20. 2010
    ..We, therefore, investigated the effect of mercuric chloride (HgCl2) on human mast cell activation...
  16. ncbi request reprint Human umbilical cord blood-derived mast cells: a unique model for the study of neuro-immuno-endocrine interactions
    T C Theoharides
    Department of Laboratory of Molecular Immunopharmacology and Drug Discovery, Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA, USA
    Stem Cell Rev 2:143-54. 2006
    ..The recent use of live cell array, with its ability to study such interactions rapidly at the single-cell level, provides unique new opportunities for fast output screening of mast cell triggers and inhibitors...
  17. ncbi request reprint The critical role of mast cells in allergy and inflammation
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
    Ann N Y Acad Sci 1088:78-99. 2006
    ..Combination of CRH receptor antagonists and mast cell inhibitors may present novel therapeutic interventions...
  18. ncbi request reprint Corticotropin-releasing hormone and the blood-brain-barrier
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts New England Medical Center, 136 Harrison Avenue, Boston, MA 02111, USA
    Front Biosci 12:1615-28. 2007
    ..Brain mast cell inhibition and CRHR antagonists offer novel therapeutic possibilities...
  19. ncbi request reprint Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, New England Medical Center, Boston, Mass 02111, USA
    Int Arch Allergy Immunol 128:344-50. 2002
    ..Serum tryptase has been increasingly used as a biochemical marker of mastocytosis, but is not always elevated...
  20. ncbi request reprint The role of mast cells in migraine pathophysiology
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts New England Medical Center, 136 Harrison Avenue, Boston, MA 02111, USA
    Brain Res Brain Res Rev 49:65-76. 2005
    ..A better understanding of brain mast cell activation in migraines would be useful and could lead to several points of prophylactic intervention...
  21. ncbi request reprint Immunomodulators for treatment of interstitial cystitis
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Urology 65:633-8. 2005
  22. doi request reprint Urticaria pigmentosa associated with acute stress and lesional skin mast-cell expression of CRF-R1
    T C Theoharides
    Department of Pharmacology, Tufts University School of Medicine, Tufts Medical Center, Boston, MA 02111, USA
    Clin Exp Dermatol 34:e163-6. 2009
    ..This is the first documented report to our knowledge of UP worsening associated with acute stress, possibly through activation of skin mast-cell CRF-R1...
  23. ncbi request reprint A pilot open label study of Cystoprotek in interstitial cystitis
    T C Theoharides
    Departments of Pharmacology and Experimental Therapeutics, Biochemistry, and Internal Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    Int J Immunopathol Pharmacol 18:183-8. 2005
    ..2 (p < 0.05) and the Problem Index from 13.1 +/- 3.7 to 5.4 +/- 4.0 (p <0.05). These results are very promising and warrant a larger study that may permit further analyses with respect to other, especially atopic, comorbid diseases...
  24. ncbi request reprint Treatment approaches for painful bladder syndrome/interstitial cystitis
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Tufts New England Medical Center, Boston, Massachusetts, USA
    Drugs 67:215-35. 2007
    ..Pilot clinical trials suggest that the flavonoid quercetin may be helpful. Lack of early diagnosis and treatment can affect outcomes and leads to the development of hyperalgesia/allodynia...
  25. ncbi request reprint Mast cells, T cells, and inhibition by luteolin: implications for the pathogenesis and treatment of multiple sclerosis
    Theoharis C Theoharides
    Department of Pharmacology, Internal Medicine and Biochemistry, Immunology Program, Tufts University School of Medicine, Tufts New England Medical Center, Boston, MA, USA
    Adv Exp Med Biol 601:423-30. 2007
    ..Pretreatment with the flavone luteolin totally blocks mast cell stimulation and T cell activation. Mast cells could constitute a new unique therapeutic target for MS...
  26. doi request reprint Novel therapeutic targets for autism
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Tufts Medical Center, Boston, MA 02111, USA
    Trends Pharmacol Sci 29:375-82. 2008
    ..We make suggestions for new research directives and possible novel therapies from readily available molecules...
  27. doi request reprint Impact of stress and mast cells on brain metastases
    Theoharis C Theoharides
    Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA
    J Neuroimmunol 205:1-7. 2008
    ..Stress and mast cells could serve as new targets for drug development to prevent brain metastases, especially since CRH receptor antagonists and brain mast cell inhibitors have recently been developed...
  28. ncbi request reprint Interstitial cystitis: bladder pain and beyond
    Theoharis C Theoharides
    Tufts University School of Medicine, Department of Pharmacology and Experimental Therapeutics, Experimental Therapeutics 136 Harrison Avenue, Boston, MA 02111, USA
    Expert Opin Pharmacother 9:2979-94. 2008
    ..Interstitial cystitis occurs primarily in females including adolescents and its diagnosis is still one of exclusion. It is now recognized as a serious medical condition associated with significant disability...
  29. doi request reprint Human mast cells stimulate activated T cells: implications for multiple sclerosis
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts Medical Center, Boston, MA 02111, USA
    Ann N Y Acad Sci 1144:74-82. 2008
    ..Interactions between mast cells and T cells could constitute a new and unique therapeutic target for multiple sclerosis...
  30. doi request reprint Autism: an emerging 'neuroimmune disorder' in search of therapy
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Tufts University School of Medicine, Tufts Medical Center, Department of Pharmacology, Boston, MA 02111, USA
    Expert Opin Pharmacother 10:2127-43. 2009
    ..There is no reliable screening test, and no definite pathogenesis or curative therapy. Consequently, there is a major gap hampering development of effective treatments...
  31. pmc Luteolin as a therapeutic option for multiple sclerosis
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA
    J Neuroinflammation 6:29. 2009
    ..An appropriate luteolin formulation that permits sufficient absorption and reduces its metabolism could be a useful adjuvant to IFN-beta for MS therapy...
  32. pmc IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, and Maternal Fetal Medicine, Tufts Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 107:4448-53. 2010
    ....
  33. doi request reprint Mast cells squeeze the heart and stretch the gird: their role in atherosclerosis and obesity
    Theoharis C Theoharides
    Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, MA 02111, USA
    Trends Pharmacol Sci 32:534-42. 2011
    ....
  34. ncbi request reprint Differential release of mast cell mediators and the pathogenesis of inflammation
    Theoharis C Theoharides
    Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Tufts New England Medical Center, Boston, MA, USA
    Immunol Rev 217:65-78. 2007
    ..Understanding this process could help develop mast cell inhibitors of selective mediator release with novel therapeutic applications...
  35. pmc Chondroitin sulphate inhibits connective tissue mast cells
    T C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts, MA 02111, USA
    Br J Pharmacol 131:1039-49. 2000
    ..5. Chondroitin sulphate appears to be a potent mast cell inhibitor of allergic and nonimmune stimulation with potential clinical implications...
  36. ncbi request reprint Acute stress shortens the time to onset of experimental allergic encephalomyelitis in SJL/J mice
    N Chandler
    Surgical Research, Tufts University School of Medicine, New England Medical Center, Boston, MA 02111, USA
    Brain Behav Immun 16:757-63. 2002
  37. ncbi request reprint Mast cells: the Jekyll and Hyde of tumor growth
    Theoharis C Theoharides
    Departments of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and New England Medical Center, 136 Harrison Avenue, Boston, MA 02111, USA
    Trends Immunol 25:235-41. 2004
  38. ncbi request reprint Critical role of mast cells in inflammatory diseases and the effect of acute stress
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts New England Medical Center, Boston, MA, USA
    J Neuroimmunol 146:1-12. 2004
    ....
  39. ncbi request reprint Cloning and cellular localization of the rat mast cell 78-kDa protein phosphorylated in response to the mast cell "stabilizer" cromolyn
    T C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA, USA
    J Pharmacol Exp Ther 294:810-21. 2000
    ..It is hypothesized that conformational changes of moesin, regulated by phosphorylation/dephosphorylation, may lead to positional rearrangements with respect to the membrane/cytoskeleton that could possibly regulate mast cell secretion...
  40. ncbi request reprint New agents for the medical treatment of interstitial cystitis
    T C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Expert Opin Investig Drugs 10:521-46. 2001
    ....
  41. ncbi request reprint Mast cells as targets of corticotropin-releasing factor and related peptides
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Trends Pharmacol Sci 25:563-8. 2004
    ....
  42. ncbi request reprint Mast cell involvement in interstitial cystitis: a review of human and experimental evidence
    T C Theoharides
    Department of Pharmacology, Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts, USA
    Urology 57:47-55. 2001
    ..Activation of mast cells, irrespective of bladder location or degree of mastocytosis, is significant. Mast cell-derived vasoactive and proinflammatory molecules may contribute to the pathogenesis of IC...
  43. ncbi request reprint Mast cells and mast cell mediators as targets of dietary supplements
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Allergy Asthma Immunol 93:S24-34. 2004
    ..To review the increasing amount of data that support or dispel the use of dietary supplements in the treatment of inflammatory conditions that involve mast cells, such as allergies, arthritis, and chronic pelvic pain syndrome...
  44. ncbi request reprint Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor
    Jing Cao
    Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA
    J Immunol 174:7665-75. 2005
    ..CRH-induced mast cell-derived VEGF could, therefore, be involved in chronic inflammatory conditions associated with increased VEGF, such as arthritis or psoriasis, both of which worsen by stress...
  45. pmc Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells
    Duraisamy Kempuraj
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
    Br J Pharmacol 145:934-44. 2005
    ..Flavonols may therefore be suitable for the treatment of allergic and inflammatory diseases...
  46. ncbi request reprint Acute stress results in skin corticotropin-releasing hormone secretion, mast cell activation and vascular permeability, an effect mimicked by intradermal corticotropin-releasing hormone and inhibited by histamine-1 receptor antagonists
    Michael Lytinas
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
    Int Arch Allergy Immunol 130:224-31. 2003
    ....
  47. ncbi request reprint The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis
    Grannum R Sant
    Department of Urology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Urology 69:34-40. 2007
    ....
  48. doi request reprint Rupatadine inhibits proinflammatory mediator secretion from human mast cells triggered by different stimuli
    Magdalini Vasiadi
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts Medical Center, Boston, Mass 02111, USA
    Int Arch Allergy Immunol 151:38-45. 2010
    ..We investigated the ability of rupatadine, a potent histamine 1 receptor antagonist that also blocks platelet-activating factor actions, to also inhibit mast cell mediator release...
  49. ncbi request reprint Azelastine inhibits secretion of IL-6, TNF-alpha and IL-8 as well as NF-kappaB activation and intracellular calcium ion levels in normal human mast cells
    Duraisamy Kempuraj
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts New England Medical Center, Boston, MA 02111, USA
    Int Arch Allergy Immunol 132:231-9. 2003
    ....
  50. doi request reprint Corticotropin-releasing hormone-receptor 2 is required for acute stress-induced bladder vascular permeability and release of vascular endothelial growth factor
    William Boucher
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
    BJU Int 106:1394-9. 2010
    ....
  51. ncbi request reprint Corticotropin-releasing hormone and brain mast cells regulate blood-brain-barrier permeability induced by acute stress
    Pamela Esposito
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111, USA
    J Pharmacol Exp Ther 303:1061-6. 2002
    ..These results demonstrate that CRH and mast cells are involved in regulating BBB permeability and, possibly, brain inflammatory disorders exacerbated by acute stress...
  52. ncbi request reprint Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in Apolipoprotein E knockout mice
    Man Huang
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Cardiovasc Res 59:241-9. 2003
    ..The current study was carried out in order to determine any possible difference in stress-induced IL-6 release in atherosclerotic mice and the contribution of mast cells, corticotropin-releasing hormone (CRH) and urocortin (Ucn)...
  53. doi request reprint Interleukin-8 is increased in gingival crevicular fluid from patients with acute pulpitis
    Virginia Karapanou
    Department of Endodontics, Tufts University School of Dental Medicine, Boston, Massachusetts 02111, USA
    J Endod 34:148-51. 2008
    ..Another group of patients (n = 7) who had received local anesthesia before sampling had very low IIP CXCL8 levels. GCF CXCL8 levels might be a useful measurement for staging patients with acute pulpitis...
  54. ncbi request reprint Topical immunopharmacology of ocular allergies
    Leonard Bielory
    Department of Medicine, UMDNJ, Asthma and Allergy Research Center, New Jersey Medical School, Newark, New Jersey, USA
    Curr Opin Allergy Clin Immunol 2:435-45. 2002
    ..To review the histamine-1 receptor antagonists, mast cell blockers and natural agents with such actions that can be used for the topical treatment of ocular allergies...
  55. ncbi request reprint Azelastine is more potent than olopatadine n inhibiting interleukin-6 and tryptase release from human umbilical cord blood-derived cultured mast cells
    Duraisamy Kempuraj
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Allergy Asthma Immunol 88:501-6. 2002
    ..Certain histamine-1 receptor antagonists and other antiallergic drugs seem to inhibit the release of mediators from rat and human mast cells...
  56. ncbi request reprint High levels of intrauterine corticotropin-releasing hormone, urocortin, tryptase, and interleukin-8 in spontaneous abortions
    Bhuvaneshwari Madhappan
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Endocrinology 144:2285-90. 2003
    ..Immunostaining of POC showed significantly more tryptase in group III women. High POC levels of CRH and Ucn under stress in habitual spontaneous abortions may activate uterine mast cells to secrete abortogenic tryptase and IL-8...
  57. ncbi request reprint Corticotropin-releasing hormone induces vascular endothelial growth factor release from human mast cells via the cAMP/protein kinase A/p38 mitogen-activated protein kinase pathway
    Jing Cao
    Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA
    Mol Pharmacol 69:998-1006. 2006
    ....
  58. ncbi request reprint Corticotropin-releasing hormone and its structurally related urocortin are synthesized and secreted by human mast cells
    Duraisamy Kempuraj
    Department of Pharmacology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Endocrinology 145:43-8. 2004
    ..These findings indicate that mast cells are not only the target, but also a potential source of CRH and Ucn that could have both autocrine and paracrine functions, especially in allergic inflammatory disorders exacerbated by stress...
  59. pmc Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process
    Jill Donelan
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Tufts New England Medical Center, 136 Harrison Avenue, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 103:7759-64. 2006
    ..These findings suggest that CRH induces skin vascular permeability through NT acting on mast cells and that both peptides should be considered in the pathogenesis of skin disorders exacerbated by stress...
  60. ncbi request reprint Azelastine's inhibition of histamine and tryptase release from human umbilical cord blood-derived cultured mast cells as well as rat skin mast cell-induced vascular permeability: comparison with olopatadine
    Michael Lytinas
    Departments of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts, USA
    Allergy Asthma Proc 23:45-51. 2002
    ..These results indicate that on an equimolar basis, azelastine was a more potent inhibitor than olopatadine of both CHMC and rat skin mast cells activation...
  61. ncbi request reprint Regulation of corticotropin-releasing hormone receptor-2 expression in human cord blood-derived cultured mast cells
    Nikoletta G Papadopoulou
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
    J Mol Endocrinol 35:R1-8. 2005
    ..These results further implicate mast cells and CRH in either initiating or potentiating inflammatory diseases, especially those affected by stress...
  62. ncbi request reprint IL-1 induces vesicular secretion of IL-6 without degranulation from human mast cells
    Kristiana Kandere-Grzybowska
    Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA
    J Immunol 171:4830-6. 2003
    ..Selective secretion of IL-6 from mast cells appears distinct from degranulation and may contribute to the development of inflammation, where the importance of IL-6 has been recognized...
  63. ncbi request reprint Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice
    Kristiana Kandere-Grzybowska
    Department of Biochemistry, Tufts University School of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
    Brain Res 980:213-20. 2003
    ..These results may help explain initial events in pathogenesis of stress-induced migraines...
  64. ncbi request reprint Acute stress induces cardiac mast cell activation and histamine release, effects that are increased in Apolipoprotein E knockout mice
    Man Huang
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Cardiovasc Res 55:150-60. 2002
    ..Here, we investigated the effect of acute stress on the activation of cardiac mast cells morphologically, as well as the levels of cardiac and serum histamine in normal and genetically deficient mice...
  65. pmc Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin
    Kristiana Kandere-Grzybowska
    Department of Biochemistry, Tufts University School of Medicine and Tufts New England Medical Center, Harrison Avenue, Boston, MA, USA
    Br J Pharmacol 148:208-15. 2006
    ....
  66. ncbi request reprint Pentosanpolysulfate (Elmiron) is a potent inhibitor of mast cell histamine secretion
    George Chiang
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, USA
    Adv Exp Med Biol 539:713-29. 2003
  67. ncbi request reprint Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria
    Nikoletta Papadopoulou
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Invest Dermatol 125:952-5. 2005
    ..The lichen simplex samples had high expression of CRH-R1, but low HDC. These results implicate CRH-R in chronic urticaria, which is often exacerbated by stress...
  68. ncbi request reprint Increased numbers of activated mast cells in endometriosis lesions positive for corticotropin-releasing hormone and urocortin
    Duraisamy Kempuraj
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Reprod Immunol 52:267-75. 2004
    ..Mast cells had previously been reported to be increased at sites of endometriosis, and tryptase may contribute to the fibrosis and inflammation characterizing endometriosis...
  69. pmc Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content
    Michael Tagen
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Tufts Medical Center, Boston, MA 02111, USA
    J Immunol 183:6313-9. 2009
    ..Our results suggest that UCP2 can regulate mast cell activation...
  70. doi request reprint Niacin-induced "flush" involves release of prostaglandin D2 from mast cells and serotonin from platelets: evidence from human cells in vitro and an animal model
    Dean Papaliodis
    Department of Pharmacology and Experimental Therapeutics, Molecular Immunopharmacology and Drug Discovery Laboratory, Tufts University School of Medicine, Tufts Medical Center, Boston, MA 02111, USA
    J Pharmacol Exp Ther 327:665-72. 2008
    ..0008), respectively, in this animal model. These results indicate that niacin-induced flush involves both PGD(2) and serotonin, suggesting that drugs other than ASA are required to effectively inhibit niacin-induced flush...
  71. ncbi request reprint Corticotropin-releasing factor (CRF) can directly affect brain microvessel endothelial cells
    Pamela Esposito
    Department of Pharmacology, Tufts University School of Medicine, New England Medical Center, 136 Harrison Avenue, Boston, MA 02111, USA
    Brain Res 968:192-8. 2003
    ..It is, therefore, possible that CRF may directly regulate BBB permeability, in addition to any effect mediated via brain mast cells...
  72. doi request reprint Mast cells and pancreatic cancer
    Theoharis C Theoharides
    Tufts University School of Medicine and Tufts Medical Center, Boston, USA
    N Engl J Med 358:1860-1. 2008
  73. ncbi request reprint Adverse cardiovascular events temporally associated with ma huang, an herbal source of ephedrine
    David Samenuk
    Division of Cardiology, New England Medical Center, Boston, MA 02111, USA
    Mayo Clin Proc 77:12-6. 2002
    ..To evaluate possible cardiovascular toxic effects associated with use of dietary supplements containing ma huang, an herbal source of ephedrine...
  74. ncbi request reprint Interleukin-16 network in inflammation and allergy
    Pio Conti
    Immunology Division, University of Chieti, Via dei Vestini, Chieti, Italy
    Allergy Asthma Proc 23:103-8. 2002
    ..In accordance with other data in the medical literature, we conclude that the most important function of IL-16 is the chemoattraction of CD4+ cells...
  75. ncbi request reprint Neuroimmunoendocrine circuitry of the 'brain-skin connection'
    Ralf Paus
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Lubeck, University of Lubeck, D 23538 Lubeck, Germany
    Trends Immunol 27:32-9. 2006
    ..Thus, the skin and its appendages enable the study of complex neuroimmunoendocrine responses that peripheral tissues launch upon stress exposure, as a basis for identifying new targets for therapeutic stress intervention...
  76. ncbi request reprint Mast cells and stress--a psychoneuroimmunological perspective
    Theoharis C Theoharides
    J Clin Psychopharmacol 22:103-8. 2002
  77. ncbi request reprint Mast cell tryptase: a new biomarker in patients with stable coronary artery disease
    Efthymios N Deliargyris
    Cardiology Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Atherosclerosis 178:381-6. 2005
    ..Tryptase measurements may emerge as a novel way of identifying asymptomatic patients with CAD, and represent a new biomarker of therapeutic efficacy in patients with CAD...
  78. ncbi request reprint Interleukin-6 and mast cells
    Pio Conti
    University of Chieti School of Medicine, Via dei Vestini, 66100 Chieti, Italy
    Allergy Asthma Proc 23:331-5. 2002
    ..IL-6 also up-regulates histamine production rather than increases its storage and is an important inducing factor for the expression of immunoglobulin E (IgE) Fc epsilon RI...
  79. ncbi request reprint Acute stress-induced seizures and loss of consciousness in a ten-year-old boy with cutaneous mastocytosis
    Christos Pehlivanidis
    J Clin Psychopharmacol 22:221-4. 2002
  80. ncbi request reprint Skin corticotropin-releasing hormone receptor expression in psoriasis
    Michael Tagen
    J Invest Dermatol 127:1789-91. 2007
  81. ncbi request reprint Relation of serum levels of mast cell tryptase of left ventricular systolic function, left ventricular volume or congestive heart failure
    Bharathi Upadhya
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Card Fail 10:31-5. 2004
    ..We sought to determine whether peripheral levels of tryptase, an MC-specific protease, are related to indices of left ventricular size and function, as well as congestive heart failure (CHF) or coronary artery disease (CAD)...
  82. ncbi request reprint Interleukin-17 and the interleukin-17 family member network
    Shu Hai Huang
    Guangxi Institute of Occupational Health, Nanning, China
    Allergy Asthma Proc 25:17-21. 2004
    ....
  83. ncbi request reprint Role of mast cells in tumor growth
    Pio Conti
    Immunology Division, Department of Oncology and Neuro science, University of Chieti, Via dei Vestini, 66100 Chieti, Italy
    Ann Clin Lab Sci 37:315-22. 2007
    ..This review focuses on the strategic importance of mast cells to the progression of tumors, and proposes a revised immune effector mechanism of mast cell involvement in tumor growth...
  84. pmc Neuroimmunology of stress: skin takes center stage
    Petra C Arck
    Biomedical Research Center, Charite, University Medicine Berlin, Berlin, Germany
    J Invest Dermatol 126:1697-704. 2006
    ....
  85. ncbi request reprint Perifollicular and perivascular mouse skin mast cells express corticotropin-releasing hormone receptor
    Jill Donelan
    J Invest Dermatol 126:929-32. 2006
  86. ncbi request reprint Flavones inhibit proliferation and increase mediator content in human leukemic mast cells (HMC-1)
    Michael Alexandrakis
    Department of Hematology, Medical Division, School of Health Sciences, University of Crete, Heraklion, Crete, Greece
    Eur J Haematol 71:448-54. 2003
    ..Some flavonoids, like quercetin, inhibit the growth of certain malignant cells in culture. Quercetin also inhibits histamine release and induces accumulation of secretory granules in rat basophilic leukemia cells...
  87. doi request reprint Environmental and occupational stress and autoimmunity
    Paolo Boscolo
    Occupational Medicine, Department of Medicine and Aging, Medical School, University of Chieti Pescara, Italy
    Autoimmun Rev 7:340-3. 2008
    ..Such a threat impacts the policy of health surveillance of the workers and requires dedication of further studies to the relationship between occupational stress and autoimmunity...
  88. ncbi request reprint Depressive symptoms in urticaria patients treated with first- or second-generation histamine 1 receptor antagonists
    Dimitris Kalogeromitros
    J Clin Psychopharmacol 27:404-6. 2007
  89. pmc Neuroendocrine-immune disequilibrium and endometriosis: an interdisciplinary approach
    Nadja Tariverdian
    Center of Internal Medicine and Dermatology, Division of PsychoNeurolmmunology, Charite, University Medicine Berlin, Berlin, Germany
    Semin Immunopathol 29:193-210. 2007
    ..Finally, we introduce the concept of endometrial dissemination as result of a neuroendocrine-immune disequilibrium in response to high levels of perceived stress caused by cardinal clinical symptoms of endometriosis...
  90. ncbi request reprint Advances in therapy with antileukotriene drugs
    Graziano Riccioni
    Department of Biomedical Sciences, University G D Annunzio, Chieti, Italy
    Ann Clin Lab Sci 34:379-87. 2004
    ....
  91. ncbi request reprint Panic disorder, interstitial cystitis, and mast cells
    Theoharis C Theoharides
    J Clin Psychopharmacol 24:361-4. 2004
  92. ncbi request reprint IL-10, an inflammatory/inhibitory cytokine, but not always
    Pio Conti
    Immunology Division, University of Chieti, School of Medicine, Chieti, Italy
    Immunol Lett 86:123-9. 2003
    ..Here, we report for the first time that IL-10 fails to inhibit tryptase and IL-6 from human mast cell-1 (HMC-1) and human umbilical cord blood-derived mast cells...
  93. ncbi request reprint Chronic fatigue syndrome, mast cells, and tricyclic antidepressants
    Theoharis C Theoharides
    J Clin Psychopharmacol 25:515-20. 2005

Research Grants18

  1. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis C Theoharides; Fiscal Year: 2010
    ..This is an important and under investigated area of skin pathophysiology that has potential applicability to understanding the pathogenesis of skin diseases and screening compounds that may develop into novel and effective treatments. ..
  2. Stress Induces Skin Mast Cell Activation & Vasodilation
    Theoharis Theoharides; Fiscal Year: 2005
    ..They will also help investigate the pathophysiology of skin syndromes exacerbated by stress, such as atopic dermatitis or psoriasis, especially since CRH and CRH receptors have been identified in human skin. ..
  3. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. ..
  4. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
  5. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis Theoharides; Fiscal Year: 2007
    ..This is an important and under investigated area of skin pathophysiology that has potential applicability to understanding the pathogenesis of skin diseases and screening compounds that may develop into novel and effective treatments. ..
  6. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis Theoharides; Fiscal Year: 2009
    ..This is an important and under investigated area of skin pathophysiology that has potential applicability to understanding the pathogenesis of skin diseases and screening compounds that may develop into novel and effective treatments. ..
  7. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
  8. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2010
    ..The proposed research is expected to advance our understanding of how activation of brain mast cells can contribute to inflammation and CFS, as well as to the development of novel and effective treatments. ..