Research Topics
Genomes and Genes | Guangwen TangSummaryAffiliation: Tufts University Country: USA Publications
Research Grants
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Detail Information
Publications
Stable isotope dilution techniques for assessing vitamin A status and bioefficacy of provitamin A carotenoids in humansHarold C Furr
Craft Technologies, 4344 Frank Price Church Road, Wilson, NC 27893, USA
Public Health Nutr 8:596-607. 2005..This review summarises recent applications of stable isotope methodology to determine human vitamin A status, estimate human vitamin A requirements, and calculate the bioconversion and bioefficacy of food carotenoids...
Techniques for measuring vitamin A activity from β-caroteneGuangwen Tang
Carotenoids and Health Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, and the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 96:1185S-8S. 2012....
β-Carotene in Golden Rice is as good as β-carotene in oil at providing vitamin A to childrenGuangwen Tang
Carotenoids and Health Laboratory, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 96:658-64. 2012..Golden Rice (GR) has been genetically engineered to be rich in β-carotene for use as a source of vitamin A...- Short-term (intestinal) and long-term (postintestinal) conversion of beta-carotene to retinol in adults as assessed by a stable-isotope reference methodGuangwen Tang
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 78:259-66. 2003..Quantitative information on the conversion of beta-carotene to vitamin A in humans is limited... - Bioconversion of dietary provitamin A carotenoids to vitamin A in humansGuangwen Tang
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 91:1468S-1473S. 2010..These findings show that the vitamin A value of individual plant foods rich in provitamin A carotenoids may vary significantly and need further investigation... - Golden Rice is an effective source of vitamin AGuangwen Tang
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
Am J Clin Nutr 89:1776-83. 2009..It is important to determine the vitamin A equivalency of Golden Rice beta-carotene to project the potential effect of this biofortified grain in rice-consuming populations that commonly exhibit low vitamin A status... - Spinach or carrots can supply significant amounts of vitamin A as assessed by feeding with intrinsically deuterated vegetablesGuangwen Tang
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, 02111, USA
Am J Clin Nutr 82:821-8. 2005..The vitamin A value of spinach and carrots needs to be measured directly... - Bioavailability of synthetic and biosynthetic deuterated lycopene in humansGuangwen Tang
Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr Biochem 16:229-35. 2005..From these preliminary investigations, we find that the bioavailability of synthetic lycopene in oil appears to be about three times higher than that of lycopene from steamed and pureed tomatoes... - Determination of carotenoids in yellow maize, the effects of saponification and food preparationsTawanda Muzhingi
Dorothy J and Gerald R Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
Int J Vitam Nutr Res 78:112-20. 2008.... - Use of a short-term isotope-dilution method for determining the vitamin A status of childrenGuangwen Tang
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 76:413-8. 2002..After a dose of labeled vitamin A is given to humans for estimating body stores of vitamin A, blood is customarily drawn at pseudo-equilibration times ranging from 11 to 26 d... - Retinaldehyde represses adipogenesis and diet-induced obesityOuliana Ziouzenkova
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Med 13:695-702. 2007..In ob/ob mice, administrating Rald or a Raldh inhibitor reduced fat and increased insulin sensitivity. These results identify Rald as a distinct transcriptional regulator of the metabolic responses to a high-fat diet... - Yellow maize with high β-carotene is an effective source of vitamin A in healthy Zimbabwean menTawanda Muzhingi
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 94:510-9. 2011..The bioconversion efficiency of yellow maize β-carotene to retinol in humans is unknown... - Asymmetric cleavage of beta-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responsesOuliana Ziouzenkova
Cardiovascular Division, Brigham and Women s Hospital, Havard University, Boston, Massachusetts 02115, USA
Mol Endocrinol 21:77-88. 2007..These results also suggest a novel model of molecular endocrinology in which metabolism of a parent compound, beta-carotene, may alternatively activate (9-cisRA) or inhibit (apo14) specific nuclear receptor responses... - Determination of 9-cis beta-carotene and zeta-carotene in biological samplesJian Qin
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr Biochem 19:612-8. 2008..1+/-0.8 and 1.1+/-0.2 nM, and 15.6+/-1.1 nM and 0.2+/-0.1 nmol/g, respectively. zetaC concentrations in the above samples were 54.2+/-7.2 and 8.3+/-1.8 nM, and 49.0+/-3.9 nM and 0.3+/-0.1 nmol/g, respectively... - Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cellsQingning Bian
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Free Radic Biol Med 53:1298-307. 2012..Similar mechanisms may explain salutary effects of lutein and zeaxanthin in reducing the risk for AMD... - Retinoids and pulmonary hypertensionIoana R Preston
Pulmonary, Critical Care and Sleep Division, Tufts-New England Medical Center, Tupper Research Institute, Boston, Mass, USA
Circulation 111:782-90. 2005..Thus, retinoic acid may influence pulmonary vascular remodeling in humans... - Kinetic analysis shows that vitamin A disposal rate in humans is positively correlated with vitamin A storesChristopher J Cifelli
Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
J Nutr 138:971-7. 2008..227) and retinol concentration (R(2) = 0.330) in all subjects. Our results support the hypothesis that VA stores are the principle determinant of VA disposal rate in healthy, well-nourished adults... - [Evaluation on intestinal and whole-body conversion of beta-carotene to vitamin A in Chinese adults using a stable isotope reference method]Zhixu Wang
Institute of Nutrition and Food Safety, Chinese Center of Diseases Control and Prevention, Beijing 100050, China
Wei Sheng Yan Jiu 32:215-21. 2003..1 to 1 on a weight basis, and about 30% of total converted retinol came from absorbed intact beta-C... - Structure determination of partially deuterated carotenoids from intrinsically labeled vegetables by HPLC-MS and 1H NMRKarsten Putzbach
Institute of Organic Chemistry, , Germany
J Agric Food Chem 53:671-7. 2005..These differences are due to isotopic effects and are based on the substitution of protons by deuterium atoms. The deuteration was distributed randomly throughout the carotenoid molecules... - Bioavailability of lutein in humans from intrinsically labeled vegetables determined by LC-APCI-MSAnnette Lienau
Institute of Organic Chemistry, University of Tuebingen, Tuebingen, Germany
J Nutr Biochem 14:663-70. 2003..4, 18.8, 18.8 and 9.8 mg labeled lutein, respectively. This technique will facilitate the study of lutein bioavailability from different foods of diverse carotenoid composition and/or following various food preparation procedures... - beta-Carotene-vitamin A equivalence in Chinese adults assessed by an isotope dilution techniqueZhixu Wang
Institute of Medical Nutrition, Qingdao University Medical College, Qingdao, China 266021
Br J Nutr 91:121-31. 2004..8 (sd 2.8):1 on a molar basis, and from 3.8:1 to 22.8:1 with an average of 9.1 (sd 5.3):1 on a weight basis. The 52 d post-intestinal absorption conversion was estimated to be about 30 % of the total converted retinol... - Vitamin A equivalence of spirulina beta-carotene in Chinese adults as assessed by using a stable-isotope reference methodJie Wang
National Institute for Nutrition and Food Safety, Beijing, China
Am J Clin Nutr 87:1730-7. 2008..Spirulina is a high-protein food supplement that contains carotenoids... - Enzymatic and oxidative metabolites of lycopeneAna Lucia dos Anjos Ferreira
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP, CP 584, 18618-970, Botucatu, SP, Brazil
J Nutr Biochem 14:531-40. 2003..These results demonstrate that both central and excentric cleavage of lycopene occurs in the rat intestinal mucosa in the presence of soy lipoxygenase... - Enzymatic and oxidative metabolites of lycopeneAna Lucia dos Anjos Ferreira
Faculdade de Medicina de Botucatu, Unviersidade Estadual Paulista (UNESP, CP 584, Botucatu, SP 18618-970, Brazil
J Nutr Biochem 15:493-502. 2004..These results demonstrate that both central and excentric cleavage of lycopene occurs in the rat intestinal mucosa in the presence of soy lipoxygenase... - Effect of lycopene on doxorubicin-induced cardiotoxicity: an echocardiographic, histological and morphometrical assessmentAna Lucia Anjos Ferreira
Department of Internal Medicine, Botucatu Faculty of Medicine, Universidade Estadual Paulista, Sao Paulo State University, Botucatu, SP, Brazil
Basic Clin Pharmacol Toxicol 101:16-24. 2007.... - Doxorubicin as an antioxidant: maintenance of myocardial levels of lycopene under doxorubicin treatmentAna Lucia Anjos Ferreira
Department of Internal Medicine, Botucatu Faculty of Medicine, UNESP, Sao Paulo State University, CEP 18618 970, Botucatu, SP, Brazil
Free Radic Biol Med 43:740-51. 2007....
Research Grants
- Retinol Equivalence of Plant Carotenoids in ChildrenGuangwen Tang; Fiscal Year: 2006..This study will be of importance in planning vitamin A deficiency prevention strategies and also will provide useful information regarding the potential efficacy of a bioengineered crop to provide vitamin A nutrition. ..