Guangwen Tang

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Stable isotope dilution techniques for assessing vitamin A status and bioefficacy of provitamin A carotenoids in humans
    Harold C Furr
    Craft Technologies, 4344 Frank Price Church Road, Wilson, NC 27893, USA
    Public Health Nutr 8:596-607. 2005
  2. doi request reprint Techniques for measuring vitamin A activity from β-carotene
    Guangwen Tang
    Carotenoids and Health Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, and the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 96:1185S-8S. 2012
  3. pmc β-Carotene in Golden Rice is as good as β-carotene in oil at providing vitamin A to children
    Guangwen Tang
    Carotenoids and Health Laboratory, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 96:658-64. 2012
  4. ncbi request reprint Short-term (intestinal) and long-term (postintestinal) conversion of beta-carotene to retinol in adults as assessed by a stable-isotope reference method
    Guangwen Tang
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 78:259-66. 2003
  5. pmc Bioconversion of dietary provitamin A carotenoids to vitamin A in humans
    Guangwen Tang
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 91:1468S-1473S. 2010
  6. pmc Golden Rice is an effective source of vitamin A
    Guangwen Tang
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 89:1776-83. 2009
  7. ncbi request reprint Spinach or carrots can supply significant amounts of vitamin A as assessed by feeding with intrinsically deuterated vegetables
    Guangwen Tang
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, 02111, USA
    Am J Clin Nutr 82:821-8. 2005
  8. ncbi request reprint Bioavailability of synthetic and biosynthetic deuterated lycopene in humans
    Guangwen Tang
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 16:229-35. 2005
  9. doi request reprint Determination of carotenoids in yellow maize, the effects of saponification and food preparations
    Tawanda Muzhingi
    Dorothy J and Gerald R Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Int J Vitam Nutr Res 78:112-20. 2008
  10. ncbi request reprint Use of a short-term isotope-dilution method for determining the vitamin A status of children
    Guangwen Tang
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:413-8. 2002

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Stable isotope dilution techniques for assessing vitamin A status and bioefficacy of provitamin A carotenoids in humans
    Harold C Furr
    Craft Technologies, 4344 Frank Price Church Road, Wilson, NC 27893, USA
    Public Health Nutr 8:596-607. 2005
    ..This review summarises recent applications of stable isotope methodology to determine human vitamin A status, estimate human vitamin A requirements, and calculate the bioconversion and bioefficacy of food carotenoids...
  2. doi request reprint Techniques for measuring vitamin A activity from β-carotene
    Guangwen Tang
    Carotenoids and Health Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, and the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 96:1185S-8S. 2012
    ....
  3. pmc β-Carotene in Golden Rice is as good as β-carotene in oil at providing vitamin A to children
    Guangwen Tang
    Carotenoids and Health Laboratory, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 96:658-64. 2012
    ..Golden Rice (GR) has been genetically engineered to be rich in β-carotene for use as a source of vitamin A...
  4. ncbi request reprint Short-term (intestinal) and long-term (postintestinal) conversion of beta-carotene to retinol in adults as assessed by a stable-isotope reference method
    Guangwen Tang
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 78:259-66. 2003
    ..Quantitative information on the conversion of beta-carotene to vitamin A in humans is limited...
  5. pmc Bioconversion of dietary provitamin A carotenoids to vitamin A in humans
    Guangwen Tang
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 91:1468S-1473S. 2010
    ..These findings show that the vitamin A value of individual plant foods rich in provitamin A carotenoids may vary significantly and need further investigation...
  6. pmc Golden Rice is an effective source of vitamin A
    Guangwen Tang
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 89:1776-83. 2009
    ..It is important to determine the vitamin A equivalency of Golden Rice beta-carotene to project the potential effect of this biofortified grain in rice-consuming populations that commonly exhibit low vitamin A status...
  7. ncbi request reprint Spinach or carrots can supply significant amounts of vitamin A as assessed by feeding with intrinsically deuterated vegetables
    Guangwen Tang
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, 02111, USA
    Am J Clin Nutr 82:821-8. 2005
    ..The vitamin A value of spinach and carrots needs to be measured directly...
  8. ncbi request reprint Bioavailability of synthetic and biosynthetic deuterated lycopene in humans
    Guangwen Tang
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 16:229-35. 2005
    ..From these preliminary investigations, we find that the bioavailability of synthetic lycopene in oil appears to be about three times higher than that of lycopene from steamed and pureed tomatoes...
  9. doi request reprint Determination of carotenoids in yellow maize, the effects of saponification and food preparations
    Tawanda Muzhingi
    Dorothy J and Gerald R Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Int J Vitam Nutr Res 78:112-20. 2008
    ....
  10. ncbi request reprint Use of a short-term isotope-dilution method for determining the vitamin A status of children
    Guangwen Tang
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:413-8. 2002
    ..After a dose of labeled vitamin A is given to humans for estimating body stores of vitamin A, blood is customarily drawn at pseudo-equilibration times ranging from 11 to 26 d...
  11. pmc Retinaldehyde represses adipogenesis and diet-induced obesity
    Ouliana Ziouzenkova
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Med 13:695-702. 2007
    ..In ob/ob mice, administrating Rald or a Raldh inhibitor reduced fat and increased insulin sensitivity. These results identify Rald as a distinct transcriptional regulator of the metabolic responses to a high-fat diet...
  12. pmc Yellow maize with high β-carotene is an effective source of vitamin A in healthy Zimbabwean men
    Tawanda Muzhingi
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 94:510-9. 2011
    ..The bioconversion efficiency of yellow maize β-carotene to retinol in humans is unknown...
  13. ncbi request reprint Asymmetric cleavage of beta-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responses
    Ouliana Ziouzenkova
    Cardiovascular Division, Brigham and Women s Hospital, Havard University, Boston, Massachusetts 02115, USA
    Mol Endocrinol 21:77-88. 2007
    ..These results also suggest a novel model of molecular endocrinology in which metabolism of a parent compound, beta-carotene, may alternatively activate (9-cisRA) or inhibit (apo14) specific nuclear receptor responses...
  14. doi request reprint Determination of 9-cis beta-carotene and zeta-carotene in biological samples
    Jian Qin
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 19:612-8. 2008
    ..1+/-0.8 and 1.1+/-0.2 nM, and 15.6+/-1.1 nM and 0.2+/-0.1 nmol/g, respectively. zetaC concentrations in the above samples were 54.2+/-7.2 and 8.3+/-1.8 nM, and 49.0+/-3.9 nM and 0.3+/-0.1 nmol/g, respectively...
  15. pmc Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells
    Qingning Bian
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 53:1298-307. 2012
    ..Similar mechanisms may explain salutary effects of lutein and zeaxanthin in reducing the risk for AMD...
  16. ncbi request reprint Retinoids and pulmonary hypertension
    Ioana R Preston
    Pulmonary, Critical Care and Sleep Division, Tufts New England Medical Center, Tupper Research Institute, Boston, Mass, USA
    Circulation 111:782-90. 2005
    ..Thus, the present study examined retinoid levels in plasma of patients with idiopathic pulmonary arterial hypertension and the effects of retinoic acid on human pulmonary artery smooth muscle cell growth...
  17. ncbi request reprint Kinetic analysis shows that vitamin A disposal rate in humans is positively correlated with vitamin A stores
    Christopher J Cifelli
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 138:971-7. 2008
    ..227) and retinol concentration (R(2) = 0.330) in all subjects. Our results support the hypothesis that VA stores are the principle determinant of VA disposal rate in healthy, well-nourished adults...
  18. ncbi request reprint [Evaluation on intestinal and whole-body conversion of beta-carotene to vitamin A in Chinese adults using a stable isotope reference method]
    Zhixu Wang
    Institute of Nutrition and Food Safety, Chinese Center of Diseases Control and Prevention, Beijing 100050, China
    Wei Sheng Yan Jiu 32:215-21. 2003
    ..This study was designed to evaluate intestinal and whole-body conversion of beta-C to vitamin A in some Chinese adults by using a stable isotope dilution technique...
  19. ncbi request reprint Structure determination of partially deuterated carotenoids from intrinsically labeled vegetables by HPLC-MS and 1H NMR
    Karsten Putzbach
    Institute of Organic Chemistry, University of Tubingen, Germany
    J Agric Food Chem 53:671-7. 2005
    ..These differences are due to isotopic effects and are based on the substitution of protons by deuterium atoms. The deuteration was distributed randomly throughout the carotenoid molecules...
  20. ncbi request reprint Bioavailability of lutein in humans from intrinsically labeled vegetables determined by LC-APCI-MS
    Annette Lienau
    Institute of Organic Chemistry, University of Tuebingen, Tuebingen, Germany
    J Nutr Biochem 14:663-70. 2003
    ..4, 18.8, 18.8 and 9.8 mg labeled lutein, respectively. This technique will facilitate the study of lutein bioavailability from different foods of diverse carotenoid composition and/or following various food preparation procedures...
  21. ncbi request reprint beta-Carotene-vitamin A equivalence in Chinese adults assessed by an isotope dilution technique
    Zhixu Wang
    Institute of Medical Nutrition, Qingdao University Medical College, Qingdao, China 266021
    Br J Nutr 91:121-31. 2004
    ..8 (sd 2.8):1 on a molar basis, and from 3.8:1 to 22.8:1 with an average of 9.1 (sd 5.3):1 on a weight basis. The 52 d post-intestinal absorption conversion was estimated to be about 30 % of the total converted retinol...
  22. ncbi request reprint Vitamin A equivalence of spirulina beta-carotene in Chinese adults as assessed by using a stable-isotope reference method
    Jie Wang
    National Institute for Nutrition and Food Safety, Beijing, China
    Am J Clin Nutr 87:1730-7. 2008
    ..Spirulina is a high-protein food supplement that contains carotenoids...
  23. ncbi request reprint Enzymatic and oxidative metabolites of lycopene
    Ana Lucia dos Anjos Ferreira
    Faculdade de Medicina de Botucatu, Universidade Estadual Paulista UNESP, CP 584, 18618 970, Botucatu, SP, Brazil
    J Nutr Biochem 14:531-40. 2003
    ..These results demonstrate that both central and excentric cleavage of lycopene occurs in the rat intestinal mucosa in the presence of soy lipoxygenase...
  24. ncbi request reprint Enzymatic and oxidative metabolites of lycopene
    Ana Lucia dos Anjos Ferreira
    Faculdade de Medicina de Botucatu, Unviersidade Estadual Paulista UNESP, CP 584, Botucatu, SP 18618 970, Brazil
    J Nutr Biochem 15:493-502. 2004
    ..These results demonstrate that both central and excentric cleavage of lycopene occurs in the rat intestinal mucosa in the presence of soy lipoxygenase...
  25. ncbi request reprint Effect of lycopene on doxorubicin-induced cardiotoxicity: an echocardiographic, histological and morphometrical assessment
    Ana Lucia Anjos Ferreira
    Department of Internal Medicine, Botucatu Faculty of Medicine, Universidade Estadual Paulista, Sao Paulo State University, Botucatu, SP, Brazil
    Basic Clin Pharmacol Toxicol 101:16-24. 2007
    ....
  26. ncbi request reprint Doxorubicin as an antioxidant: maintenance of myocardial levels of lycopene under doxorubicin treatment
    Ana Lucia Anjos Ferreira
    Department of Internal Medicine, Botucatu Faculty of Medicine, UNESP, Sao Paulo State University, CEP 18618 970, Botucatu, SP, Brazil
    Free Radic Biol Med 43:740-51. 2007
    ....

Research Grants4

  1. Retinol Equivalence of Plant Carotenoids in Children
    Guangwen Tang; Fiscal Year: 2003
    ..This study will be of importance in planning vitamin A deficiency prevention strategies and also will provide useful information regarding the potential efficacy of a bioengineered crop to provide vitamin A nutrition. ..
  2. Retinol Equivalence of Plant Carotenoids in Children
    Guangwen Tang; Fiscal Year: 2004
    ..This study will be of importance in planning vitamin A deficiency prevention strategies and also will provide useful information regarding the potential efficacy of a bioengineered crop to provide vitamin A nutrition. ..
  3. Retinol Equivalence of Plant Carotenoids in Children
    Guangwen Tang; Fiscal Year: 2005
    ..This study will be of importance in planning vitamin A deficiency prevention strategies and also will provide useful information regarding the potential efficacy of a bioengineered crop to provide vitamin A nutrition. ..
  4. Retinol Equivalence of Plant Carotenoids in Children
    Guangwen Tang; Fiscal Year: 2006
    ..This study will be of importance in planning vitamin A deficiency prevention strategies and also will provide useful information regarding the potential efficacy of a bioengineered crop to provide vitamin A nutrition. ..