Lesley A Stevens

Summary

Affiliation: Tufts Medical Center
Country: USA

Publications

  1. pmc Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/min/1.73 m2
    Lesley A Stevens
    Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 56:486-95. 2010
  2. ncbi request reprint Evaluating the performance of equations for estimating glomerular filtration rate
    Lesley A Stevens
    Tufts University School of Medicine, Tufts Medical Center, 800 Washington Street, Box 391 Boston, MA 02111, USA
    J Nephrol 21:797-807. 2008
  3. doi request reprint Factors other than glomerular filtration rate affect serum cystatin C levels
    Lesley A Stevens
    Division of Nephrology, Clinical Care Research, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 75:652-60. 2009
  4. doi request reprint Current status and future perspectives for CKD testing
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 53:S17-26. 2009
  5. pmc Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 54:33-42. 2009
  6. pmc Chronic kidney disease and end-stage renal disease in the elderly population: current prevalence, future projections, and clinical significance
    Lesley A Stevens
    Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Adv Chronic Kidney Dis 17:293-301. 2010
  7. doi request reprint Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 79:555-62. 2011
  8. pmc Development and validation of GFR-estimating equations using diabetes, transplant and weight
    Lesley A Stevens
    Tufts Medical Center, Boston, MA, USA
    Nephrol Dial Transplant 25:449-57. 2010
  9. doi request reprint Measured GFR as a confirmatory test for estimated GFR
    Lesley A Stevens
    Tufts Medical Center, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:2305-13. 2009
  10. doi request reprint Impact of reporting estimated glomerular filtration rate: it's not just about us
    Lesley A Stevens
    Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 76:245-7. 2009

Detail Information

Publications40

  1. pmc Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/min/1.73 m2
    Lesley A Stevens
    Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 56:486-95. 2010
    ..Here, performance of a more accurate GFR-estimating equation, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, is reported by level of GFR and clinical characteristics...
  2. ncbi request reprint Evaluating the performance of equations for estimating glomerular filtration rate
    Lesley A Stevens
    Tufts University School of Medicine, Tufts Medical Center, 800 Washington Street, Box 391 Boston, MA 02111, USA
    J Nephrol 21:797-807. 2008
    ....
  3. doi request reprint Factors other than glomerular filtration rate affect serum cystatin C levels
    Lesley A Stevens
    Division of Nephrology, Clinical Care Research, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 75:652-60. 2009
    ..Hence, we found that cystatin C is affected by factors other than GFR which should be considered when the GFR is estimated using serum levels of cystatin C...
  4. doi request reprint Current status and future perspectives for CKD testing
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 53:S17-26. 2009
    ..Repeated testing for urine protein and interpretation of GFR estimates in the context of kidney damage and the clinical context of patient presentation can help overcome these limitations...
  5. pmc Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 54:33-42. 2009
    ....
  6. pmc Chronic kidney disease and end-stage renal disease in the elderly population: current prevalence, future projections, and clinical significance
    Lesley A Stevens
    Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Adv Chronic Kidney Dis 17:293-301. 2010
    ....
  7. doi request reprint Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 79:555-62. 2011
    ..Thus, heterogeneity in performance among the ethnic and geographic groups precludes use of the four-level race equation. The CKD-EPI two-level race equation can be used in the United States and Europe across a wide range of ethnicity...
  8. pmc Development and validation of GFR-estimating equations using diabetes, transplant and weight
    Lesley A Stevens
    Tufts Medical Center, Boston, MA, USA
    Nephrol Dial Transplant 25:449-57. 2010
    ..Here, we describe the development and validation of this equation as well as other equations that incorporate diabetes, transplant and weight as additional predictor variables...
  9. doi request reprint Measured GFR as a confirmatory test for estimated GFR
    Lesley A Stevens
    Tufts Medical Center, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:2305-13. 2009
    ..We suggest plasma clearance of nonradioactive markers be more widely implemented in clinical settings. Further research is necessary on the impact of the use of measured GFR as a confirmatory test...
  10. doi request reprint Impact of reporting estimated glomerular filtration rate: it's not just about us
    Lesley A Stevens
    Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 76:245-7. 2009
    ..In our view, a complete assessment requires a broader perspective. Most patients with CKD do not require referral to a nephrologist. Improving outcomes requires coordinated efforts of all physicians...
  11. doi request reprint Prevalence of CKD and comorbid illness in elderly patients in the United States: results from the Kidney Early Evaluation Program (KEEP)
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Am J Kidney Dis 55:S23-33. 2010
    ..In all 3 data sources, we also explored comorbid conditions and CKD-related complications...
  12. pmc Advances in glomerular filtration rate-estimating equations
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Curr Opin Nephrol Hypertens 19:298-307. 2010
    ..Here, we review the performance of current creatinine and cystatin C-based estimating equations as well as demonstration of their utility in public health and clinical practice...
  13. pmc Comparison of the CKD Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) study equations: risk factors for and complications of CKD and mortality in the Kidney Early Evaluation Program (KEEP)
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 57:S9-16. 2011
    ..Before implementing this change in the Kidney Early Evaluation Program (KEEP), we compared characteristics of reclassified individuals and mortality risk predictions using the new equation...
  14. ncbi request reprint Impact of creatinine calibration on performance of GFR estimating equations in a pooled individual patient database
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 50:21-35. 2007
    ..Variation in performance of glomerular filtration rate (GFR) estimating equations is related to variation in calibration of the creatinine assay across clinical laboratories...
  15. doi request reprint A predictive model for progression of chronic kidney disease to kidney failure
    Navdeep Tangri
    Department of Medicine, Tufts Medical Center, 800 Washington St, PO Box 391, Boston, MA 02111, USA
    JAMA 305:1553-9. 2011
    ....
  16. pmc Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 51:395-406. 2008
    ..We report the development and evaluation of GFR-estimating equations using serum cystatin C alone and serum cystatin C, serum creatinine, or both with demographic variables...
  17. pmc A new equation to estimate glomerular filtration rate
    Andrew S Levey
    Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 150:604-12. 2009
    ..Equations to estimate glomerular filtration rate (GFR) are routinely used to assess kidney function. Current equations have limited precision and systematically underestimate measured GFR at higher values...
  18. ncbi request reprint Evaluation of the modification of diet in renal disease study equation in a large diverse population
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    J Am Soc Nephrol 18:2749-57. 2007
    ..73 m(2). In individual patients, interpretation of GFR estimates near 60 ml/min per 1.73 m(2) should be interpreted with caution to avoid misclassification of chronic kidney disease in the context of the clinical setting...
  19. ncbi request reprint Prevalence of ICD-9-CM codes for chronic kidney disease in individuals with cardiovascular disease risk factors
    Ashish Mahajan
    Tufts Medical Center Scientific and Clinical Research Center, Boston, Massachusetts, USA
    J Nephrol 22:523-33. 2009
    ..Chronic kidney disease (CKD) is a risk factor for cardiovascular disease (CVD)...
  20. ncbi request reprint Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values
    Andrew S Levey
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Clin Chem 53:766-72. 2007
    ..We sought to reexpress the 4-variable Modification of Diet in Renal Disease (MDRD) Study equation for estimation of glomerular filtration rate (GFR) using serum creatinine (S(cr)) standardized to reference methods...
  21. doi request reprint Standardization of serum creatinine and estimated GFR in the Kidney Early Evaluation Program (KEEP)
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 51:S77-82. 2008
    ..We describe the calibration of creatinine assays used in the National Kidney Foundation Kidney Early Evaluation Program (KEEP)...
  22. doi request reprint Changes in dietary protein intake has no effect on serum cystatin C levels independent of the glomerular filtration rate
    Navdeep Tangri
    Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 79:471-7. 2011
    ..Hence, cystatin C may allow more accurate estimates of GFR than creatinine for patients with reduced protein intake. Further study of other non-GFR determinants of cystatin C is needed before the widespread adoption...
  23. ncbi request reprint Assessing kidney function--measured and estimated glomerular filtration rate
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    N Engl J Med 354:2473-83. 2006
  24. pmc Comparison of CKD awareness in a screening population using the Modification of Diet in Renal Disease (MDRD) study and CKD Epidemiology Collaboration (CKD-EPI) equations
    Manjula Kurella Tamura
    Department of Medicine, Division of Nephrology, Stanford University, Palo Alto, CA 94304, USA
    Am J Kidney Dis 57:S17-23. 2011
    ..Whether reclassification of CKD severity using the CKD Epidemiology Collaboration (CKD-EPI) equation to estimate glomerular filtration rate (GFR) modifies estimates of CKD awareness is unknown...
  25. ncbi request reprint Low rates of testing and diagnostic codes usage in a commercial clinical laboratory: evidence for lack of physician awareness of chronic kidney disease
    Lesley A Stevens
    Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    J Am Soc Nephrol 16:2439-48. 2005
    ....
  26. ncbi request reprint Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 145:247-54. 2006
    ..The 4-variable equation from the Modification of Diet in Renal Disease (MDRD) Study has been reexpressed for use with a standardized assay...
  27. ncbi request reprint Cystatin C and creatinine in an HIV cohort: the nutrition for healthy living study
    Clara Y Jones
    Tufts University School of Medicine, Boston, MA 02111, USA
    Am J Kidney Dis 51:914-24. 2008
    ..Serum creatinine level may underestimate the prevalence of CKD in subjects with decreased lean body mass or liver disease. Level of serum cystatin C, an alternative kidney function marker, is independent of lean body mass...
  28. pmc Early change in proteinuria as a surrogate outcome in kidney disease progression: a systematic review of previous analyses and creation of a patient-level pooled dataset
    Nicholas Stoycheff
    Tufts Medical Center, Boston, MA, USA
    Nephrol Dial Transplant 26:848-57. 2011
    ..There is a reasonably sound biological basis for this hypothesis, but only preliminary empirical evidence currently exists...
  29. pmc Risk factors for proteinuria in HIV-infected and -uninfected Hispanic drug users
    Martin S Rhee
    Department of Medicine, Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 52:683-90. 2008
    ..Minorities are at greater risk of chronic kidney disease. Data are limited about risk factors for proteinuria in Hispanic drug users with and without HIV infection...
  30. ncbi request reprint Variation in the serum creatinine assay calibration: a practical application to glomerular filtration rate estimation
    Kalyani Murthy
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts, USA
    Kidney Int 68:1884-7. 2005
    ..Variation among clinical laboratories in calibration of serum creatinine assays is a source of error in glomerular filtration rate (GFR) estimation equations. We evaluated impact of this variation on GFR estimates...
  31. ncbi request reprint Surrogate end points for clinical trials of kidney disease progression
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    Clin J Am Soc Nephrol 1:874-84. 2006
  32. doi request reprint Chronic kidney disease, diabetes, and hypertension: what's in a name?
    Andrew S Levey
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 78:19-22. 2010
    ..We provide data on the frequency of diabetes, hypertension, or both, according to albumin-to-creatinine ratio and eGFR, and review the rationale for retaining the current name...
  33. doi request reprint Conceptual model of CKD: applications and implications
    Andrew S Levey
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 53:S4-16. 2009
    ....
  34. ncbi request reprint Automatic reporting of estimated glomerular filtration rate--just what the doctor ordered
    Andrew S Levey
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
    Clin Chem 52:2188-93. 2006
  35. ncbi request reprint Serum cystatin C as a marker of glomerular filtration rate
    Magdalena Madero
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts, USA
    Curr Opin Nephrol Hypertens 15:610-6. 2006
    ..This review summarizes the currently available glomerular filtration rate estimating equations based on cystatin C and the literature comparing cystatin C and creatinine as filtration markers...
  36. ncbi request reprint Nephrotic syndrome in diabetic kidney disease: an evaluation and update of the definition
    Nicholas Stoycheff
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 54:840-9. 2009
    ..These threshold levels have not been rigorously evaluated in patients with diabetic kidney disease or by using urine albumin excretion, the preferred measure of proteinuria in patients with diabetes...
  37. ncbi request reprint Toward optimal health: Lesley A. Stevens, M.D. discusses issues of chronic kidney disease in women. Interview by Jodi R. Godfrey
    Lesley A Stevens
    Tufts University School of Medicine, Boston, Massachusetts, USA
    J Womens Health (Larchmt) 15:123-6. 2006
  38. ncbi request reprint Measurement of kidney function
    Lesley A Stevens
    Division of Nephrology, Tufts University School of Medicine, Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    Med Clin North Am 89:457-73. 2005
    ..The current recommended method is to use estimating equations based on serum creatinine and which incorporate demographic and clinical variables...
  39. doi request reprint Prevalence of and risk factors for chronic kidney disease in rural Nicaragua
    Julie K O'Donnell
    ASPH CDC Allan Rosenfield Global Health Fellowship Program, Washington, DC, USA
    Nephrol Dial Transplant 26:2798-805. 2011
    ..The true prevalence, nature and aetiology of kidney disease in this region remain unknown...
  40. ncbi request reprint Calcium, phosphate, and parathyroid hormone levels in combination and as a function of dialysis duration predict mortality: evidence for the complexity of the association between mineral metabolism and outcomes
    Lesley A Stevens
    Division of Nephrology, New England Medical Centre, Boston, Massachusetts, USA
    J Am Soc Nephrol 15:770-9. 2004
    ..In so doing, the complex interaction of time and MM can begin to be understand. Further exploration is required...