Fu Shang

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. pmc Roles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degeneration
    Fu Shang
    Laboratory for Nutrition and Vision Research, USDA Human Nutrition Research Center on Aging, Boston, MA 02111, USA
    Mol Aspects Med 33:446-66. 2012
  2. pmc Ubiquitin-proteasome pathway and cellular responses to oxidative stress
    Fu Shang
    Laboratory for Nutrition and Vision Research, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 51:5-16. 2011
  3. ncbi request reprint Vitamin C and vitamin E restore the resistance of GSH-depleted lens cells to H2O2
    Fu Shang
    JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 34:521-30. 2003
  4. pmc Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation
    Fu Shang
    Laboratory for Nutrition and Vision Research, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 280:20365-74. 2005
  5. pmc Differential regulation of components of the ubiquitin-proteasome pathway during lens cell differentiation
    Weimin Guo
    Laboratory for Nutrition and Vision Research, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 45:1194-201. 2004
  6. ncbi request reprint Ubiquitin-proteasome pathway function is required for lens cell proliferation and differentiation
    Weimin Guo
    Laboratory for Nutrition and Vision Research, JMUSDA HNRCA, Department of Ophthalmology, Tufts University, Boston, MA 02111, USA
    Invest Ophthalmol Vis Sci 47:2569-75. 2006
  7. ncbi request reprint Expression of K6W-ubiquitin inhibits proliferation of human lens epithelial cells
    Qing Liu
    Laboratory for Nutrition and Vision Research, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Mol Vis 12:931-6. 2006
  8. ncbi request reprint Regulation of the ubiquitin proteasome pathway in human lens epithelial cells during the cell cycle
    Qing Liu
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Exp Eye Res 78:197-205. 2004
  9. pmc Degradation of C-terminal truncated alpha A-crystallins by the ubiquitin-proteasome pathway
    Xinyu Zhang
    Laboratory for Nutrition and Vision Research, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 48:4200-8. 2007
  10. pmc The proteasome: a target of oxidative damage in cultured human retina pigment epithelial cells
    Xinyu Zhang
    United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 49:3622-30. 2008

Collaborators

Detail Information

Publications35

  1. pmc Roles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degeneration
    Fu Shang
    Laboratory for Nutrition and Vision Research, USDA Human Nutrition Research Center on Aging, Boston, MA 02111, USA
    Mol Aspects Med 33:446-66. 2012
    ....
  2. pmc Ubiquitin-proteasome pathway and cellular responses to oxidative stress
    Fu Shang
    Laboratory for Nutrition and Vision Research, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 51:5-16. 2011
    ..Thus, increased levels of ubiquitin conjugates in cells seem to be an indicator of mild oxidative stress...
  3. ncbi request reprint Vitamin C and vitamin E restore the resistance of GSH-depleted lens cells to H2O2
    Fu Shang
    JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 34:521-30. 2003
    ..Moreover, levels of these nutrients must be optimized to achieve the maximal benefit...
  4. pmc Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation
    Fu Shang
    Laboratory for Nutrition and Vision Research, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 280:20365-74. 2005
    ..Taken together, these results show that Lys(6)-modified ubiquitin is a potent and specific inhibitor of ubiquitin-mediated protein degradation...
  5. pmc Differential regulation of components of the ubiquitin-proteasome pathway during lens cell differentiation
    Weimin Guo
    Laboratory for Nutrition and Vision Research, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 45:1194-201. 2004
    ..To investigate the role for the ubiquitin-proteasome pathway in controlling lens cell proliferation and differentiation and the regulation of the ubiquitin conjugation machinery during the differentiation process...
  6. ncbi request reprint Ubiquitin-proteasome pathway function is required for lens cell proliferation and differentiation
    Weimin Guo
    Laboratory for Nutrition and Vision Research, JMUSDA HNRCA, Department of Ophthalmology, Tufts University, Boston, MA 02111, USA
    Invest Ophthalmol Vis Sci 47:2569-75. 2006
    ..The objective of this work was to investigate roles for this proteolytic pathway in controlling the differentiation of lens epithelial cells into lens fibers...
  7. ncbi request reprint Expression of K6W-ubiquitin inhibits proliferation of human lens epithelial cells
    Qing Liu
    Laboratory for Nutrition and Vision Research, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Mol Vis 12:931-6. 2006
    ..The ubiquitin-proteasome pathway plays an important role in controlling the cell cycle. The purpose of this study was to examine if expression of a dominant negative form of ubiquitin can inhibit the proliferation of lens epithelial cells...
  8. ncbi request reprint Regulation of the ubiquitin proteasome pathway in human lens epithelial cells during the cell cycle
    Qing Liu
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Exp Eye Res 78:197-205. 2004
    ..Some of the variations in levels of ubiquitin conjugating enzymes are suggestive of previously undescribed functions...
  9. pmc Degradation of C-terminal truncated alpha A-crystallins by the ubiquitin-proteasome pathway
    Xinyu Zhang
    Laboratory for Nutrition and Vision Research, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 48:4200-8. 2007
    ..The objective of the present study was to explore the role of the ubiquitin-proteasome pathway (UPP) in degrading C-terminal truncated alpha A-crystallins...
  10. pmc The proteasome: a target of oxidative damage in cultured human retina pigment epithelial cells
    Xinyu Zhang
    United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 49:3622-30. 2008
    ..The objective of this study was to investigate the effect of oxidative stress on the UPP in cultured human retina pigment epithelial cells...
  11. pmc Oligomerization with wt αA- and αB-crystallins reduces proteasome-mediated degradation of C-terminally truncated αA-crystallin
    Mingxing Wu
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Invest Ophthalmol Vis Sci 53:2541-50. 2012
    ..The objective of this work was to determine the effects of wt αA- and αB-crystallins on the degradation of C-terminally truncated αA-crystallin (αA(1-162)) and vice versa...
  12. pmc Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics)
    Tomoaki Uchiki
    Laboratory for Nutrition and Vision Research, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Aging Cell 11:1-13. 2012
    ..Together, these data explain why AGEs accumulate as glycative stress increases...
  13. pmc Oxidative inactivation of the proteasome in retinal pigment epithelial cells. A potential link between oxidative stress and up-regulation of interleukin-8
    Alexandre F Fernandes
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Biol Chem 283:20745-53. 2008
    ....
  14. pmc Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells
    Qingning Bian
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 53:1298-307. 2012
    ..Similar mechanisms may explain salutary effects of lutein and zeaxanthin in reducing the risk for AMD...
  15. pmc Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation and increases interleukin-8 production in retinal pigment epithelial cells
    Alexandre F Fernandes
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Mol Biol Cell 20:3690-9. 2009
    ..Together, these data elucidate a novel signaling network that leads to increased IL-8 production in response to proteasome inactivation...
  16. doi request reprint Dietary supplementation with high dose of epigallocatechin-3-gallate promotes inflammatory response in mice
    Munkyong Pae
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 23:526-31. 2012
    ....
  17. pmc Ubiquitin proteasome pathway-mediated degradation of proteins: effects due to site-specific substrate deamidation
    Edward J Dudek
    Laboratory for Nutrition and Vision Research, United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111 1524, USA
    Invest Ophthalmol Vis Sci 51:4164-73. 2010
    ..Among the roles of the ubiquitin proteasome pathway (UPP) is protein surveillance and maintenance of protein quality. The purpose of this study was to determine whether deamidation can alter clearance of crystallins by the UPP...
  18. pmc Proteasome-dependent regulation of signal transduction in retinal pigment epithelial cells
    Alexandre F Fernandes
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Exp Eye Res 83:1472-81. 2006
    ..Taken together, these data predict that the impairment of the UPP could lead to the development of AMD-related phenotypes...
  19. pmc Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells
    Carla Marques
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    FASEB J 18:1424-6. 2004
    ..Taken together, these findings show that HNE-modified proteins are degraded via a novel ubiquitin and lysosomal-dependent but proteasome-independent pathway...
  20. ncbi request reprint Lens fibers have a fully functional ubiquitin-proteasome pathway
    Paulo Pereira
    Laboratory for Nutrition and Vision Research, USDA HNRC at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Exp Eye Res 76:623-31. 2003
    ..Since Ubc4 and Ubc5 are involved in selectively ubiquitinating damaged or abnormal proteins, the decline in levels and activities of these E2s may be responsible for the accumulation of abnormal proteins in inner regions of the lens...
  21. pmc The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones
    Carla Marques
    Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    FASEB J 20:741-3. 2006
    ..Isopeptidases, the enzymes that reverse the actions of CHIP, also play an important role in determining the fate of denatured proteins...
  22. pmc Glutathiolation enhances the degradation of gammaC-crystallin in lens and reticulocyte lysates, partially via the ubiquitin-proteasome pathway
    Madeleine Zetterberg
    Laboratory for Nutrition and Vision Research, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, 02111, USA
    Invest Ophthalmol Vis Sci 47:3467-73. 2006
    ..S-glutathiolated proteins are formed in the lens during aging and cataractogenesis. The objective of this work was to explore the role of the ubiquitin-proteasome pathway in eliminating S-glutathiolated gammaC-crystallin...
  23. ncbi request reprint Ubiquitin-conjugating enzyme 3 delays human lens epithelial cells in metaphase
    Qing Liu
    Laboratory for Nutrition and Vision Research, JMUSDA HNRCA at Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 47:1302-9. 2006
    ..Expecting to find similar effects in human lens epithelial cells (HLECs), the authors explored roles for this ubiquitin-conjugating enzyme in regulation of the HLEC cycle...
  24. pmc Natural history of age-related retinal lesions that precede AMD in mice fed high or low glycemic index diets
    Karen A Weikel
    Laboratory for Nutrition and Vision Research, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 53:622-32. 2012
    ..The authors sought corroboration of this observation in an animal model...
  25. ncbi request reprint Ubiquitination capabilities in response to neocarzinostatin and H(2)O(2) stress in cell lines from patients with ataxia-telangiectasia
    Allen Taylor
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Laboratory for Nutrition and Vision Research, 711 Washington Street, Boston, Massachusetts 02111, USA
    Oncogene 21:4363-73. 2002
    ..The data also add support to the impression that potentiated ubiquitination response to mild oxidative stress is a generalizable phenomenon...
  26. pmc Perturbing the ubiquitin pathway reveals how mitosis is hijacked to denucleate and regulate cell proliferation and differentiation in vivo
    Andrea Caceres
    Laboratory for Nutrition and Vision Research, US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America
    PLoS ONE 5:e13331. 2010
    ..Ubiquitination controls many critical cellular processes, most of which require specific lysines on ubiquitin (Ub). Of the 7 lysines (K) least is known about effects of modification of K6...
  27. ncbi request reprint Function of the ubiquitin proteolytic pathway in the eye
    Fu Shang
    Laboratory for Nutrition and Vision Research, USDA Human Nutrition Research Center on Aging, 711 Washington St, Boston MA 02111, USA
    Exp Eye Res 78:1-14. 2004
    ..In this review we will explain the biochemistry of the UP and we will document the most important studies regarding UP function in the lens, retina and cornea...
  28. doi request reprint Epigallocatechin-3-gallate directly suppresses T cell proliferation through impaired IL-2 utilization and cell cycle progression
    Munkyong Pae
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 140:1509-15. 2010
    ..CD4(+) cells are more responsive to EGCG than CD8(+) cells. Future studies should determine the effect of EGCG on CD4(+) cell subsets to assess its application in T cell-mediated autoimmune diseases...
  29. pmc Associations between genetic polymorphisms of insulin-like growth factor axis genes and risk for age-related macular degeneration
    Chung Jung Chiu
    U S Department of Agriculture USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Invest Ophthalmol Vis Sci 52:9099-107. 2011
    ..To investigate whether insulin-like growth factor (IGF) axis genes, together with a novel dietary risk factor, the dietary glycemic index (dGI), and body mass index (BMI) affect the risk for age-related macular degeneration (AMD)...
  30. pmc Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking
    Amy Lin
    Department of Biology, Boston University, Boston, Massachusetts, USA
    J Neurochem 119:27-39. 2011
    ..These data indicate that Nedd4 is the E3 ubiquitin ligase responsible for AMPAR ubiquitination, a modification that regulates multiple aspects of AMPAR molecular biology including trafficking, localization and stability...
  31. doi request reprint Role of the ubiquitin-proteasome in protein quality control and signaling: implication in the pathogenesis of eye diseases
    Fu Shang
    Laboratory for Nutrition and Vision Research, USDA Human Nutrition Research Center on Aging, Boston, Massachusetts, USA
    Prog Mol Biol Transl Sci 109:347-96. 2012
    ..Methods that enhance or preserve UPP function or reduce its burden may be useful strategies for preventing age-related eye diseases...
  32. pmc A novel alphaB-crystallin mutation associated with autosomal dominant congenital lamellar cataract
    Yizhi Liu
    Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 47:1069-75. 2006
    ..To identify the mutation and the underlying mechanism of cataractogenesis in a five-generation autosomal dominant congenital lamellar cataract family...
  33. pmc Subcellular redistribution of components of the ubiquitin-proteasome pathway during lens differentiation and maturation
    Henrique Girao
    Center of Ophthalmology, Biomedical Institute for Research in Light and Image, University of Coimbra, Portugal
    Invest Ophthalmol Vis Sci 46:1386-92. 2005
    ..The primary nuclear localization of the UPP components in the differentiating fibers supports the hypothesis that the UPP may play a role in elimination of nuclei and other organelles during differentiation and maturation of lens fibers...
  34. ncbi request reprint 7-ketocholesterol stimulates differentiation of lens epithelial cells
    Henrique Girao
    Centre of Ophthalmology, Biomedical Institute for Research in Light and Image IBILI, Faculty of Medicine, University of Coimbra, Portugal
    Mol Vis 9:497-501. 2003
    ..To establish if oxysterols stimulate differentiation of lens epithelial cells (LEC)...
  35. ncbi request reprint Sex-linked differences in cataract progression in Emory mice
    Fu Shang
    Exp Eye Res 75:109-11. 2002

Research Grants6

  1. Role of ubiquitin in quality control of lens proteins
    Fu Shang; Fiscal Year: 2007
    ..abstract_text> ..
  2. Role of ubiquitin in quality control of lens proteins
    Fu Shang; Fiscal Year: 2010
    ..The proposed work will increase our knowledge of how the lens maintains its transparent function and will potentially identify targets of pharmaceutical interventions for prevention or treatment of age-related cataract. ..