Harry P Selker

Summary

Affiliation: Tufts Medical Center
Country: USA

Publications

  1. ncbi One-Year Outcomes of Out-of-Hospital Administration of Intravenous Glucose, Insulin, and Potassium (GIK) in Patients With Suspected Acute Coronary Syndromes (from the IMMEDIATE [Immediate Myocardial Metabolic Enhancement During Initial Assessment and Trea
    Harry P Selker
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts Electronic address
    Am J Cardiol 113:1599-605. 2014
  2. doi A proposal for integrated efficacy-to-effectiveness (E2E) clinical trials
    H P Selker
    1 Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts, USA 2 Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
    Clin Pharmacol Ther 95:147-53. 2014
  3. doi Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial
    Harry P Selker
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    JAMA 307:1925-33. 2012
  4. ncbi Study design for the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) Trial: A double-blind randomized controlled trial of intravenous glucose, insulin, and potassium for acute coronary syndr
    Harry P Selker
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Am Heart J 163:315-22. 2012
  5. pmc Random treatment assignment using mathematical equipoise for comparative effectiveness trials
    Harry P Selker
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts, USA
    Clin Transl Sci 4:10-6. 2011
  6. ncbi Emergency medical service predictive instrument-aided diagnosis and treatment of acute coronary syndromes and ST-segment elevation myocardial infarction in the IMMEDIATE trial
    Harry P Selker
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Prehosp Emerg Care 15:139-48. 2011
  7. ncbi Clinical features, triage, and outcome of patients presenting to the ED with suspected acute coronary syndromes but without pain: a multicenter study
    Boris E Coronado
    Center for Cardioivascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Dept of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Am J Emerg Med 22:568-74. 2004
  8. pmc Comparative effectiveness of ST-segment-elevation myocardial infarction regionalization strategies
    Thomas W Concannon
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Circ Cardiovasc Qual Outcomes 3:506-13. 2010
  9. pmc Elapsed time in emergency medical services for patients with cardiac complaints: are some patients at greater risk for delay?
    Thomas W Concannon
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    Circ Cardiovasc Qual Outcomes 2:9-15. 2009
  10. ncbi Comparison of mortality benefit of immediate thrombolytic therapy versus delayed primary angioplasty for acute myocardial infarction
    David M Kent
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Am J Cardiol 99:1384-8. 2007

Detail Information

Publications41

  1. ncbi One-Year Outcomes of Out-of-Hospital Administration of Intravenous Glucose, Insulin, and Potassium (GIK) in Patients With Suspected Acute Coronary Syndromes (from the IMMEDIATE [Immediate Myocardial Metabolic Enhancement During Initial Assessment and Trea
    Harry P Selker
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts Electronic address
    Am J Cardiol 113:1599-605. 2014
    ..However, in those with ST elevation myocardial infarction, the composites of cardiac arrest or 1-year mortality, and of cardiac arrest, mortality, or HF hospitalization within 1 year, were significantly reduced. ..
  2. doi A proposal for integrated efficacy-to-effectiveness (E2E) clinical trials
    H P Selker
    1 Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts, USA 2 Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
    Clin Pharmacol Ther 95:147-53. 2014
    ....
  3. doi Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial
    Harry P Selker
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    JAMA 307:1925-33. 2012
    ..Clinical trials have not consistently shown these benefits, possibly due to delayed administration...
  4. ncbi Study design for the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) Trial: A double-blind randomized controlled trial of intravenous glucose, insulin, and potassium for acute coronary syndr
    Harry P Selker
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Am Heart J 163:315-22. 2012
    ..A trial of GIK used in the very first hours of ischemia has been needed, consistent with the timing of benefit seen in experimental studies...
  5. pmc Random treatment assignment using mathematical equipoise for comparative effectiveness trials
    Harry P Selker
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts, USA
    Clin Transl Sci 4:10-6. 2011
    ..This approach may have utility for comparative effectiveness trials and for application of trial results to clinical practice...
  6. ncbi Emergency medical service predictive instrument-aided diagnosis and treatment of acute coronary syndromes and ST-segment elevation myocardial infarction in the IMMEDIATE trial
    Harry P Selker
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Prehosp Emerg Care 15:139-48. 2011
    ....
  7. ncbi Clinical features, triage, and outcome of patients presenting to the ED with suspected acute coronary syndromes but without pain: a multicenter study
    Boris E Coronado
    Center for Cardioivascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Dept of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Am J Emerg Med 22:568-74. 2004
    ..There is a need for greater awareness in the general public of the different manifestations of ACS to enhance the recognition of and prompt response to their symptoms...
  8. pmc Comparative effectiveness of ST-segment-elevation myocardial infarction regionalization strategies
    Thomas W Concannon
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Circ Cardiovasc Qual Outcomes 3:506-13. 2010
    ..This study evaluated the comparative effectiveness of ST-segment-elevation myocardial infarction regionalization strategies to increase the use of PCI against standard emergency transport and care...
  9. pmc Elapsed time in emergency medical services for patients with cardiac complaints: are some patients at greater risk for delay?
    Thomas W Concannon
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    Circ Cardiovasc Qual Outcomes 2:9-15. 2009
    ..For many patients, first contact with the health system is through emergency medical services (EMS). We set out to identify patient-level and neighborhood-level factors that were associated with elapsed time in EMS...
  10. ncbi Comparison of mortality benefit of immediate thrombolytic therapy versus delayed primary angioplasty for acute myocardial infarction
    David M Kent
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Am J Cardiol 99:1384-8. 2007
    ..Previous meta-regressions appear to have underestimated the PPCI-related delay that would nullify the incremental benefits of PPCI...
  11. doi A percutaneous coronary intervention-thrombolytic predictive instrument to assist choosing between immediate thrombolytic therapy versus delayed primary percutaneous coronary intervention for acute myocardial infarction
    David M Kent
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 101:790-5. 2008
    ..Incorporated into electrocardiogram, it may assist targeting PCI to those who benefit most and identifying patients before hospitalization for whom a receiving hospital should prepare for PCI...
  12. ncbi Tissue plasminogen activator was cost-effective compared to streptokinase in only selected patients with acute myocardial infarction
    David M Kent
    Clinical Research and Health Policy Studies, Tufts New England Medical Center Tufts University School of Medicine, 750 Washington Street, Box 63, Boston, MA 02111, USA
    J Clin Epidemiol 57:843-52. 2004
    ..We sought to explore the patient-specific cost-effectiveness in a community-based sample for a therapy for which the average cost-effectiveness in a clinical trial has been well-described...
  13. ncbi A geospatial analysis of emergency transport and inter-hospital transfer in ST-segment elevation myocardial infarction
    Thomas W Concannon
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 101:69-74. 2008
    ..In conclusion, the selection of high-benefit patients for transport or transfer to PCI-capable hospitals can reduce mortality while minimizing major shifts in hospital patient volumes...
  14. ncbi Differences in triage thresholds for patients presenting with possible acute coronary syndromes: more than meets the eye
    Catherine E Milch
    Institute for Clinical Research and Health Policy Studies, Center for Cardiovascular Health Services Research, Tufts New England Medical Center, Boston, MA 02111, USA
    J Investig Med 54:76-85. 2006
    ..Many studies have shown differences in cardiac care by racial/ethnic groups without accounting for institutional factors at the location of care...
  15. ncbi Can multivariable risk-benefit profiling be used to select treatment-favorable patients for thrombolysis in stroke in the 3- to 6-hour time window?
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Stroke 37:2963-9. 2006
    ..We sought to examine whether such a multivariate predictive instrument might be useful in selecting patients with a favorable risk-benefit treatment profile for therapy after 3 hours...
  16. ncbi Time-dependent predictors of primary cardiac arrest in patients with acute myocardial infarction
    Harry P Selker
    Center for Cardiovascular Health Services Research, Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Cardiol 91:280-6. 2003
    ..Those with prolonged QTc or substantial ST elevation who survive the initial 1.5-hour period are those less susceptible to these risks...
  17. ncbi Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, 750 Washington Street, 63, Boston, MA, 02111, USA
    Stroke 36:62-5. 2005
    ..We explored whether sex might modify the effect of recombinant tissue plasminogen activator (rtPA) on outcomes in patients with acute ischemic stroke...
  18. ncbi The impact of electrocardiographic left ventricular hypertrophy and bundle branch block on the triage and outcome of ED patients with a suspected acute coronary syndrome: a multicenter study
    J Hector Pope
    Center for Cardiobascular Health Services Research, Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Emerg Med 22:156-63. 2004
    ..With a short-term mortality rate 3.5 times that for patients without ECG-LVH, selected patients with ECG-LVH and symptoms suggesting ACS might benefit from hospitalization for further evaluation...
  19. ncbi An independently derived and validated predictive model for selecting patients with myocardial infarction who are likely to benefit from tissue plasminogen activator compared with streptokinase
    David M Kent
    Division of Clinical Care Research, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Med 113:104-11. 2002
    ..3% 30-day mortality, compared with a mortality of 7.3% among those treated with streptokinase, despite a greater risk of intracranial hemorrhage with tPA. However, in part because of its higher cost, tPA has not been adopted universally...
  20. ncbi Diagnosis of acute cardiac ischemia
    J Hector Pope
    New England Medical Center, 750 Washington Street 163, Boston, MA, 02111, USA
    Emerg Med Clin North Am 21:27-59. 2003
    ....
  21. pmc Improving use of prehospital 12-lead ECG for early identification and treatment of acute coronary syndrome and ST-elevation myocardial infarction
    Denise H Daudelin
    Center for Cardiovascular Health Services Research, Tufts Medical Center, Boston, MA, USA
    Circ Cardiovasc Qual Outcomes 3:316-23. 2010
    ..To fully realize this benefit, emergency medical service performance must be measured and used in feedback reporting and quality improvement...
  22. ncbi The stroke-thrombolytic predictive instrument: a predictive instrument for intravenous thrombolysis in acute ischemic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Stroke 37:2957-62. 2006
    ..Therefore, we aimed to develop a Stroke-Thrombolytic Predictive Instrument (TPI) to aid physicians considering thrombolysis for stroke...
  23. ncbi In acute ischemic stroke, are asymptomatic intracranial hemorrhages clinically innocuous?
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, 750 Washington St, Box 63, Boston, Mass 02111, USA
    Stroke 35:1141-6. 2004
    ..We examined whether the occurrence of an asymptomatic intracranial hemorrhage affects functional outcome in patients with acute ischemic stroke (AIS) treated or not treated with recombinant tissue plasminogen activator (rt-PA)...
  24. doi Disparate use of minimally invasive surgery in benign surgical conditions
    Rocco Ricciardi
    Department of Colon and Rectal Surgery, Lahey Clinic, Tufts University, 41 Mall Road, Burlington, MA 01805, USA
    Surg Endosc 22:1977-86. 2008
    ..Given that surgery is a rapidly evolving field, we hypothesized that racial disparities exist in access to minimally invasive surgery (MIS), which importantly influences outcome...
  25. pmc The Stroke Practice Improvement Network: a quasiexperimental trial of a multifaceted intervention to improve quality
    Judith A Hinchey
    Institute of Clinical Care Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts 02135, USA
    J Stroke Cerebrovasc Dis 19:130-7. 2010
    ....
  26. ncbi Myocardial perfusion imaging for evaluation and triage of patients with suspected acute cardiac ischemia: a randomized controlled trial
    James E Udelson
    Division of Clinical Care Research, Tufts New England Medical Center, 750 Washington St, Box 70, Boston, MA 02111, USA
    JAMA 288:2693-700. 2002
    ....
  27. ncbi External validity of predictive models: a comparison of logistic regression, classification trees, and neural networks
    Norma Terrin
    Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, and Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111, USA
    J Clin Epidemiol 56:721-9. 2003
    ..We report a simulation study that compared the external validity of standard logistic regression (LR1), logistic regression with piecewise-linear and quadratic terms (LR2), classification trees, and neural networks (NNETs)...
  28. ncbi Are some patients likely to benefit from recombinant tissue-type plasminogen activator for acute ischemic stroke even beyond 3 hours from symptom onset?
    David M Kent
    Division of Clinical Care Research, Tufts New England Medical Center, Boston, Mass 02111, USA
    Stroke 34:464-7. 2003
    ....
  29. ncbi Development and validation of a patient-specific predictive instrument for the need for dose reduction in chemotherapy for breast cancer: a potential decision aid for the use of myeloid growth factors
    Panos Savvides
    Division of Hematology Oncology, School of Medicine, New England Medical Center and Tufts University, Boston, MA 02111, USA
    Support Care Cancer 11:313-20. 2003
    ..This instrument could help clinicians select patients who will benefit from early administration of myeloid growth factors...
  30. ncbi Medical error prevention in ED triage for ACS: use of cardiac care decision support and quality improvement feedback
    Denise H Daudelin
    Tufts University School of Medicine, and Tufts New England Medical Center, Boston, MA 02111, USA
    Cardiol Clin 23:601-14, ix. 2005
    ....
  31. ncbi Electrocardiograph-based emergency department risk management tool based on the ACI-TIPI: potential impact on care and malpractice claims
    Harry P Selker
    New England Medical Center, Tufts University School of Medicine, Boston, USA
    J Healthc Risk Manag 22:11-7. 2002
  32. pmc Is primary angioplasty for some as good as primary angioplasty for all?
    David M Kent
    Received from the Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, Boston, Mass 02111, USA
    J Gen Intern Med 17:887-94. 2002
    ..To investigate whether proper patient selection might allow most of the benefits of population-wide primary coronary angioplasty to be captured in a subgroup of high-risk patients...
  33. doi Risk factor model to predict venous thromboembolism in hospitalized medical patients
    Michael B Rothberg
    Center for Quality of Care Research, Baystate Medical Center, Springfield, Massachusetts, USA
    J Hosp Med 6:202-9. 2011
    ..The Joint Commission requires that all medical inpatients be assessed for venous thromboembolism (VTE) risk, but available risk stratification tools have never been validated...
  34. ncbi Lessons learned combining N-of-1 trials to assess fibromyalgia therapies
    Deborah R Zucker
    Tufts University School of Medicine and Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Rheumatol 33:2069-77. 2006
    ..We combined N-of-1 trials to compare fibromyalgia therapies and to assess the feasibility and outcomes of this approach for practice-based effectiveness research...
  35. ncbi Use of the electrocardiograph-based thrombolytic predictive instrument to assist thrombolytic and reperfusion therapy for acute myocardial infarction. A multicenter, randomized, controlled, clinical effectiveness trial
    Harry P Selker
    Tufts New England Medical Center, Division of Clinical Care Research, 750 Washington Street 63, Boston, MA 0211, USA
    Ann Intern Med 137:87-95. 2002
    ....
  36. ncbi A community consultation survey to evaluate support for and success of the IMMEDIATE trial
    Joni R Beshansky
    aCenter for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Clin Trials 11:178-86. 2014
    ..Information from community consultation regarding the community acceptance might inform this question...
  37. ncbi Factors associated with longer time to treatment for patients with suspected acute coronary syndromes: a cohort study
    Alison L Sullivan
    Baystate Medical Center, and Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA and Tufts University School of Medicine, and Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA
    Circ Cardiovasc Qual Outcomes 7:86-94. 2014
    ..Rapid treatment of acute coronary syndromes (ACS) is important; causes of delay in emergency medical services care of ACS are poorly understood...
  38. doi Volume-outcome relationship for coronary artery bypass grafting in an era of decreasing volume
    Rocco Ricciardi
    Department of Colon and Rectal Surgery, Lahey Clinic, Tufts University, 41 Mall Rd, Burlington, MA 01805, USA
    Arch Surg 143:338-44; discussion 344. 2008
    ..We hypothesized that the recent reduction in procedure volume for coronary artery bypass grafting (CABG) has led to an increase in the in-hospital mortality rate...
  39. ncbi Smoking cessation in primary care: a clinical effectiveness trial of two simple interventions
    Catherine E Milch
    Division of Clinical Care Research, Tufts New England Medical Center, Boston, MA 02111, USA
    Prev Med 38:284-94. 2004
    ..We designed a study to assess the relative effectiveness of two brief interventions on screening for smoking, physician cessation advice and patient smoking cessation rates...
  40. ncbi Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial
    Michael L Dansinger
    Division of Endocrinology, Diabetes, and Metabolism, Atherosclerosis Research Laboratory, Tufts New England Medical Center, Boston, Mass 02111, USA
    JAMA 293:43-53. 2005
    ....