Research Topics
| Harry P SelkerSummaryAffiliation: Tufts Medical Center Country: USA Publications
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Detail Information
Publications
Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trialHarry P Selker
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
JAMA 307:1925-33. 2012..Clinical trials have not consistently shown these benefits, possibly due to delayed administration...- Study design for the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) Trial: A double-blind randomized controlled trial of intravenous glucose, insulin, and potassium for acute coronary syndrHarry P Selker
Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
Am Heart J 163:315-22. 2012..A trial of GIK used in the very first hours of ischemia has been needed, consistent with the timing of benefit seen in experimental studies... 
Random treatment assignment using mathematical equipoise for comparative effectiveness trialsHarry P Selker
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts, USA
Clin Transl Sci 4:10-6. 2011..This approach may have utility for comparative effectiveness trials and for application of trial results to clinical practice...- Emergency medical service predictive instrument-aided diagnosis and treatment of acute coronary syndromes and ST-segment elevation myocardial infarction in the IMMEDIATE trialHarry P Selker
Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Prehosp Emerg Care 15:139-48. 2011.... 
Clinical features, triage, and outcome of patients presenting to the ED with suspected acute coronary syndromes but without pain: a multicenter studyBoris E Coronado
Center for Cardioivascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Dept. of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
Am J Emerg Med 22:568-74. 2004..There is a need for greater awareness in the general public of the different manifestations of ACS to enhance the recognition of and prompt response to their symptoms...- Comparative effectiveness of ST-segment-elevation myocardial infarction regionalization strategiesThomas W Concannon
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
Circ Cardiovasc Qual Outcomes 3:506-13. 2010..This study evaluated the comparative effectiveness of ST-segment-elevation myocardial infarction regionalization strategies to increase the use of PCI against standard emergency transport and care... - A percutaneous coronary intervention-thrombolytic predictive instrument to assist choosing between immediate thrombolytic therapy versus delayed primary percutaneous coronary intervention for acute myocardial infarctionDavid M Kent
Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
Am J Cardiol 101:790-5. 2008..Incorporated into electrocardiogram, it may assist targeting PCI to those who benefit most and identifying patients before hospitalization for whom a receiving hospital should prepare for PCI... - Elapsed time in emergency medical services for patients with cardiac complaints: are some patients at greater risk for delay?Thomas W Concannon
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
Circ Cardiovasc Qual Outcomes 2:9-15. 2009..For many patients, first contact with the health system is through emergency medical services (EMS). We set out to identify patient-level and neighborhood-level factors that were associated with elapsed time in EMS... - Comparison of mortality benefit of immediate thrombolytic therapy versus delayed primary angioplasty for acute myocardial infarctionDavid M Kent
Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
Am J Cardiol 99:1384-8. 2007..Previous meta-regressions appear to have underestimated the PPCI-related delay that would nullify the incremental benefits of PPCI... - Tissue plasminogen activator was cost-effective compared to streptokinase in only selected patients with acute myocardial infarctionDavid M Kent
Clinical Research and Health Policy Studies, Tufts New England Medical Center Tufts University School of Medicine, 750 Washington Street, Box 63, Boston, MA 02111, USA
J Clin Epidemiol 57:843-52. 2004..We sought to explore the patient-specific cost-effectiveness in a community-based sample for a therapy for which the average cost-effectiveness in a clinical trial has been well-described... - Differences in triage thresholds for patients presenting with possible acute coronary syndromes: more than meets the eyeCatherine E Milch
Institute for Clinical Research and Health Policy Studies, Center for Cardiovascular Health Services Research, Tufts New England Medical Center, Boston, MA 02111, USA
J Investig Med 54:76-85. 2006..Many studies have shown differences in cardiac care by racial/ethnic groups without accounting for institutional factors at the location of care... - Can multivariable risk-benefit profiling be used to select treatment-favorable patients for thrombolysis in stroke in the 3- to 6-hour time window?David M Kent
Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
Stroke 37:2963-9. 2006..We sought to examine whether such a multivariate predictive instrument might be useful in selecting patients with a favorable risk-benefit treatment profile for therapy after 3 hours... - Time-dependent predictors of primary cardiac arrest in patients with acute myocardial infarctionHarry P Selker
Center for Cardiovascular Health Services Research, Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Am J Cardiol 91:280-6. 2003..Those with prolonged QTc or substantial ST elevation who survive the initial 1.5-hour period are those less susceptible to these risks... - Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trialsDavid M Kent
Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, 750 Washington Street, 63, Boston, MA, 02111, USA
Stroke 36:62-5. 2005..We explored whether sex might modify the effect of recombinant tissue plasminogen activator (rtPA) on outcomes in patients with acute ischemic stroke... - A geospatial analysis of emergency transport and inter-hospital transfer in ST-segment elevation myocardial infarctionThomas W Concannon
Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
Am J Cardiol 101:69-74. 2008..In conclusion, the selection of high-benefit patients for transport or transfer to PCI-capable hospitals can reduce mortality while minimizing major shifts in hospital patient volumes... - The impact of electrocardiographic left ventricular hypertrophy and bundle branch block on the triage and outcome of ED patients with a suspected acute coronary syndrome: a multicenter studyJ Hector Pope
Center for Cardiobascular Health Services Research, Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Am J Emerg Med 22:156-63. 2004..With a short-term mortality rate 3.5 times that for patients without ECG-LVH, selected patients with ECG-LVH and symptoms suggesting ACS might benefit from hospitalization for further evaluation... - Diagnosis of acute cardiac ischemiaJ Hector Pope
New England Medical Center, 750 Washington Street 163, Boston, MA, 02111, USA
Emerg Med Clin North Am 21:27-59. 2003.... - Improving use of prehospital 12-lead ECG for early identification and treatment of acute coronary syndrome and ST-elevation myocardial infarctionDenise H Daudelin
Center for Cardiovascular Health Services Research, Tufts Medical Center, Boston, MA, USA
Circ Cardiovasc Qual Outcomes 3:316-23. 2010..To fully realize this benefit, emergency medical service performance must be measured and used in feedback reporting and quality improvement... - In acute ischemic stroke, are asymptomatic intracranial hemorrhages clinically innocuous?David M Kent
Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, 750 Washington St, Box 63, Boston, Mass 02111, USA
Stroke 35:1141-6. 2004..We examined whether the occurrence of an asymptomatic intracranial hemorrhage affects functional outcome in patients with acute ischemic stroke (AIS) treated or not treated with recombinant tissue plasminogen activator (rt-PA)... - The stroke-thrombolytic predictive instrument: a predictive instrument for intravenous thrombolysis in acute ischemic strokeDavid M Kent
Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
Stroke 37:2957-62. 2006..Therefore, we aimed to develop a Stroke-Thrombolytic Predictive Instrument (TPI) to aid physicians considering thrombolysis for stroke... - An independently derived and validated predictive model for selecting patients with myocardial infarction who are likely to benefit from tissue plasminogen activator compared with streptokinaseDavid M Kent
Division of Clinical Care Research, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Am J Med 113:104-11. 2002..3% 30-day mortality, compared with a mortality of 7.3% among those treated with streptokinase, despite a greater risk of intracranial hemorrhage with tPA. However, in part because of its higher cost, tPA has not been adopted universally... - Disparate use of minimally invasive surgery in benign surgical conditionsRocco Ricciardi
Department of Colon and Rectal Surgery, Lahey Clinic, Tufts University, 41 Mall Road, Burlington, MA 01805, USA
Surg Endosc 22:1977-86. 2008..Given that surgery is a rapidly evolving field, we hypothesized that racial disparities exist in access to minimally invasive surgery (MIS), which importantly influences outcome... - The Stroke Practice Improvement Network: a quasiexperimental trial of a multifaceted intervention to improve qualityJudith A Hinchey
Institute of Clinical Care Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts 02135, USA
J Stroke Cerebrovasc Dis 19:130-7. 2010.... - Myocardial perfusion imaging for evaluation and triage of patients with suspected acute cardiac ischemia: a randomized controlled trialJames E Udelson
Division of Clinical Care Research, Tufts New England Medical Center, 750 Washington St, Box 70, Boston, MA 02111, USA
JAMA 288:2693-700. 2002.... - External validity of predictive models: a comparison of logistic regression, classification trees, and neural networksNorma Terrin
Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, and Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111, USA
J Clin Epidemiol 56:721-9. 2003..We report a simulation study that compared the external validity of standard logistic regression (LR1), logistic regression with piecewise-linear and quadratic terms (LR2), classification trees, and neural networks (NNETs)... - Medical error prevention in ED triage for ACS: use of cardiac care decision support and quality improvement feedbackDenise H Daudelin
Tufts University School of Medicine, and Tufts-New England Medical Center, Boston, MA 02111, USA
Cardiol Clin 23:601-14, ix. 2005.... - Development and validation of a patient-specific predictive instrument for the need for dose reduction in chemotherapy for breast cancer: a potential decision aid for the use of myeloid growth factorsPanos Savvides
Division of Hematology-Oncology, School of Medicine, New England Medical Center and Tufts University, Boston, MA 02111, USA
Support Care Cancer 11:313-20. 2003..This instrument could help clinicians select patients who will benefit from early administration of myeloid growth factors... - Are some patients likely to benefit from recombinant tissue-type plasminogen activator for acute ischemic stroke even beyond 3 hours from symptom onset?David M Kent
Division of Clinical Care Research, Tufts New England Medical Center, Boston, Mass 02111, USA
Stroke 34:464-7. 2003.... - Electrocardiograph-based emergency department risk management tool based on the ACI-TIPI: potential impact on care and malpractice claimsHarry P Selker
New England Medical Center, Tufts University School of Medicine, Boston, USA
J Healthc Risk Manag 22:11-7. 2002 - Is primary angioplasty for some as good as primary angioplasty for all?David M Kent
Received from the Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, Boston, Mass 02111, USA
J Gen Intern Med 17:887-94. 2002..To investigate whether proper patient selection might allow most of the benefits of population-wide primary coronary angioplasty to be captured in a subgroup of high-risk patients... - Risk factor model to predict venous thromboembolism in hospitalized medical patientsMichael B Rothberg
Center for Quality of Care Research, Baystate Medical Center, Springfield, Massachusetts, USA
J Hosp Med 6:202-9. 2011..The Joint Commission requires that all medical inpatients be assessed for venous thromboembolism (VTE) risk, but available risk stratification tools have never been validated... - Lessons learned combining N-of-1 trials to assess fibromyalgia therapiesDeborah R Zucker
Tufts University School of Medicine and Tufts New England Medical Center, Boston, Massachusetts 02111, USA
J Rheumatol 33:2069-77. 2006..We combined N-of-1 trials to compare fibromyalgia therapies and to assess the feasibility and outcomes of this approach for practice-based effectiveness research... - Use of the electrocardiograph-based thrombolytic predictive instrument to assist thrombolytic and reperfusion therapy for acute myocardial infarction. A multicenter, randomized, controlled, clinical effectiveness trialHarry P Selker
Tufts New England Medical Center, Division of Clinical Care Research, 750 Washington Street 63, Boston, MA 0211, USA
Ann Intern Med 137:87-95. 2002.... - Volume-outcome relationship for coronary artery bypass grafting in an era of decreasing volumeRocco Ricciardi
Department of Colon and Rectal Surgery, Lahey Clinic, Tufts University, 41 Mall Rd, Burlington, MA 01805, USA
Arch Surg 143:338-44; discussion 344. 2008..We hypothesized that the recent reduction in procedure volume for coronary artery bypass grafting (CABG) has led to an increase in the in-hospital mortality rate... - Smoking cessation in primary care: a clinical effectiveness trial of two simple interventionsCatherine E Milch
Division of Clinical Care Research, Tufts New England Medical Center, Boston, MA 02111, USA
Prev Med 38:284-94. 2004..We designed a study to assess the relative effectiveness of two brief interventions on screening for smoking, physician cessation advice and patient smoking cessation rates... - Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trialMichael L Dansinger
Division of Endocrinology, Diabetes, and Metabolism, Atherosclerosis Research Laboratory, Tufts New England Medical Center, Boston, Mass 02111, USA
JAMA 293:43-53. 2005....