Jacob Selhub

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. pmc Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis
    En Pei I Chiang
    Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, Taiwan 402, Republic of China
    Arthritis Res Ther 7:R1404-11. 2005
  2. pmc Inflammation causes tissue-specific depletion of vitamin B6
    En Pei Chiang
    Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan
    Arthritis Res Ther 7:R1254-62. 2005
  3. pmc Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency
    Jacob Selhub
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 89:702S-6S. 2009
  4. ncbi Public health significance of elevated homocysteine
    Jacob Selhub
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Food Nutr Bull 29:S116-25. 2008
  5. ncbi The many facets of hyperhomocysteinemia: studies from the Framingham cohorts
    Jacob Selhub
    Vitamin Metabolism and Aging Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 136:1726S-1730S. 2006
  6. ncbi The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status
    Jacob Selhub
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Food Nutr Bull 29:S67-73. 2008
  7. doi B vitamins and the aging brain
    Jacob Selhub
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Nutr Rev 68:S112-8. 2010
  8. doi Folic acid fortification: why not vitamin B12 also?
    Jacob Selhub
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Biofactors 37:269-71. 2011
  9. ncbi Public health significance of supplementation or fortification of grain products with folic acid
    Jacob Selhub
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Food Nutr Bull 29:S173-6. 2008
  10. pmc In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations
    Jacob Selhub
    Vitamin Metabolism Laboratory and Nutritional Epidemiology Program, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 104:19995-20000. 2007

Collaborators

Detail Information

Publications95

  1. pmc Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis
    En Pei I Chiang
    Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, Taiwan 402, Republic of China
    Arthritis Res Ther 7:R1404-11. 2005
    ..Data from the present study suggest that patients with rheumatoid arthritis may have higher requirements for vitamin B6 than those in a normal healthy population...
  2. pmc Inflammation causes tissue-specific depletion of vitamin B6
    En Pei Chiang
    Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan
    Arthritis Res Ther 7:R1254-62. 2005
    ..The low plasma pyridoxal 5'-phosphate levels seen in inflammation are unlikely to be due to insufficient intake or excessive vitamin B6 excretion. Possible causes of decreased levels of vitamin B6 are discussed...
  3. pmc Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency
    Jacob Selhub
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 89:702S-6S. 2009
    ....
  4. ncbi Public health significance of elevated homocysteine
    Jacob Selhub
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Food Nutr Bull 29:S116-25. 2008
    ..Whether this denominator is homocysteine itself or homocysteine is merely a marker, remains to be determined...
  5. ncbi The many facets of hyperhomocysteinemia: studies from the Framingham cohorts
    Jacob Selhub
    Vitamin Metabolism and Aging Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 136:1726S-1730S. 2006
    ..Whether this denominator is homocysteine itself or whether homocysteine is merely a marker remains to be determined...
  6. ncbi The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status
    Jacob Selhub
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Food Nutr Bull 29:S67-73. 2008
    ..For serum vitamin B12, the cutoff would be 150 pmol/L based on lowest methylmalonic acid and 300 pmol/L based on lowest homocysteine...
  7. doi B vitamins and the aging brain
    Jacob Selhub
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Nutr Rev 68:S112-8. 2010
    ..In light of this, it is imperative to find safe ways of improving vitamin B status in the elderly without exposing some individuals to undue risk...
  8. doi Folic acid fortification: why not vitamin B12 also?
    Jacob Selhub
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Biofactors 37:269-71. 2011
    ..Hence any food fortification policy that includes folic acid should also include vitamin B12...
  9. ncbi Public health significance of supplementation or fortification of grain products with folic acid
    Jacob Selhub
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Food Nutr Bull 29:S173-6. 2008
  10. pmc In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations
    Jacob Selhub
    Vitamin Metabolism Laboratory and Nutritional Epidemiology Program, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 104:19995-20000. 2007
    ..These results suggest a worsening of vitamin B(12)'s enzymatic functions as folate status increases in people who are vitamin B(12)-deficient...
  11. pmc Effect of combined folic acid, vitamin B(6), and vitamin B(12) on colorectal adenoma
    Yiqing Song
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    J Natl Cancer Inst 104:1562-75. 2012
    ..Folic acid, vitamin B(6), and vitamin B(12) act in concert in the one-carbon metabolism and may protect against colorectal neoplasia. We examined the effect of combined B-vitamin treatment on the occurrence of colorectal adenoma...
  12. pmc Status of vitamins B-12 and B-6 but not of folate, homocysteine, and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults
    Denish Moorthy
    Neuroscience and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Nutr 142:1554-60. 2012
    ..The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression...
  13. doi Cognitive dysfunction and depression in adult kidney transplant recipients: baseline findings from the FAVORIT Ancillary Cognitive Trial (FACT)
    Aron M Troen
    Nutrition and Neurocognition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    J Ren Nutr 22:268-76.e1-3. 2012
    ..Accordingly, we assessed the prevalence of cognitive impairment and depressive symptoms in transplant recipients and their association with kidney function, plasma total homocysteine, and B-vitamin concentrations...
  14. ncbi Preconception homocysteine and B vitamin status and birth outcomes in Chinese women
    Alayne G Ronnenberg
    Departments of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 76:1385-91. 2002
    ..The associations between homocysteine, B vitamin status, and pregnancy outcomes have not been examined prospectively...
  15. ncbi Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004
    Martha Savaria Morris
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 87:1446-54. 2008
    ....
  16. pmc Plasma vitamin B(6) and risk of myocardial infarction in women
    John H Page
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Circulation 120:649-55. 2009
    ..We prospectively evaluated the relationships between fasting plasma levels of vitamin B(6), as pyridoxal phosphate, and subsequent myocardial infarction risk in women...
  17. pmc Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification
    Martha Savaria Morris
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 85:193-200. 2007
    ..This idea is controversial, however, because observational data are few and inconclusive. Furthermore, experimental investigation is unethical...
  18. ncbi Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 87:734-43. 2008
    ..B vitamins such as folate, vitamin B-6, and vitamin B-12 are coenzymes that are important for DNA integrity and stability. Deficiency in these B vitamins may promote tumor carcinogenesis...
  19. ncbi Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homocysteine concentrations in the Framingham Offspring Study Cohort
    Giuseppina T Russo
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:3416-21. 2003
    ..001). Our results suggest that age and sex modify the contribution of the MTHFR C677T mutation to fasting tHcy concentrations...
  20. doi Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors
    Martha Savaria Morris
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 91:1733-44. 2010
    ..However, clinical consequences of vitamin B-12 deficiency may be worsened by high folic acid intakes, perhaps as a direct result of unmetabolized folic acid, which does not occur naturally in body tissues...
  21. pmc Plasma homocysteine and cysteine and risk of breast cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 70:2397-405. 2010
    ..The increased risk of breast cancer associated with high cysteine levels warrants further investigation...
  22. pmc A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate
    Renee D Kalmbach
    Vitamin Metabolism and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 138:2323-7. 2008
    ..4 nmol/L). Our results suggest the del/del polymorphism in DHFR is a functional polymorphism, because it limits assimilation of folic acid into cellular folate stores at high and low folic acid intakes...
  23. ncbi Homocysteine in chronic kidney disease: Effect of low protein diet and repletion with B vitamins
    Vandana Menon
    Department of Medicine, Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 67:1539-46. 2005
    ..Data are limited on the determinants of homocysteine (tHcy) and its relationship with nutritional indices, and dietary protein intake, in the earlier stages of chronic kidney disease (CKD)...
  24. pmc Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine
    Aron M Troen
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 138:2502-9. 2008
    ....
  25. pmc Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women
    Robert R McLean
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Clin Endocrinol Metab 93:2206-12. 2008
    ..Elevated homocysteine is a strong risk factor for osteoporotic fractures among elders, yet it may be a marker for low B-vitamin status...
  26. pmc Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study
    Sudha Seshadri
    Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
    Arch Neurol 65:642-9. 2008
    ..Elevated plasma total homocysteine (tHcy) levels have been associated with increased risk of dementia and stroke, but it is uncertain whether the mediating mechanisms are predominantly cellular, vascular, or both...
  27. pmc Prospective study of plasma vitamin B6 and risk of colorectal cancer in men
    Jung Eun Lee
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:1197-202. 2009
    ..92 (0.55-1.56), 0.42 (0.23-0.75), and 0.49 (0.26-0.92; P(trend) = 0.01), respectively. In conclusion, vitamin B(6) may protect against colorectal cancer independent of other one-carbon metabolites and inflammatory biomarkers...
  28. ncbi Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston MA 02111, USA
    J Nutr 134:750-5. 2004
    ..05). This vitamin B-12-deficient diet, which was of insufficient severity to cause anemia or illness, created aberrations in both base substitution and methylation of colonic DNA, which might increase susceptibility to carcinogenesis...
  29. pmc Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Hum Mol Genet 18:4677-87. 2009
    ..40 x 10(-15)). Genome-wide significant loci were not identified for plasma folate. These data reveal new biological candidates and confirm prior candidate genes for plasma homocysteine, plasma vitamin B12 and plasma PLP...
  30. pmc Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adults
    Lydia Sakakeeny
    Vitamin Metabolism Laboratory, Tufts University, Boston, MA, USA
    J Nutr 142:1280-5. 2012
    ..We discuss 2 possible roles for PLP in the inflammatory process, including tryptophan metabolism and serine hydroxymethyltransferase activity...
  31. ncbi Plasma vitamin B6 and the risk of colorectal cancer and adenoma in women
    Esther K Wei
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 97:684-92. 2005
    ..However, no previous epidemiologic studies have directly evaluated the association of plasma PLP with risk for colorectal neoplasia...
  32. ncbi B vitamins and plasma homocysteine concentrations in an urban and rural area of Costa Rica
    Mi Kyung Kim
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Am Coll Nutr 22:224-31. 2003
    ..Plasma folate and vitamin B(12) concentrations were measured in women...
  33. pmc Uracil misincorporation into DNA and folic acid supplementation
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 91:160-5. 2010
    ..Folate deficiency decreases thymidylate synthesis from deoxyuridylate, which results in an imbalance of deoxyribonucleotide that may lead to excessive uracil misincorporation (UrMis) into DNA during replication and repair...
  34. ncbi Relationship between homocysteine and mortality in chronic kidney disease
    Vandana Menon
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, MA, USA
    Circulation 113:1572-7. 2006
    ..The relationship between total homocysteine (tHcy) and outcomes has not been investigated in patients with chronic kidney disease stages 3 to 4...
  35. ncbi Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trial
    Katherine L Tucker
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Clin Nutr 79:805-11. 2004
    ..High homocysteine and low B vitamin concentrations have been linked to the risk of vascular disease, stroke, and dementia and are relatively common in older adults...
  36. ncbi The cognitive impact of nutritional homocysteinemia in apolipoprotein-E deficient mice
    Aron M Troen
    Jean Mayer USDA Human Nutrition Research Centre on Aging, Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    J Alzheimers Dis 9:381-92. 2006
    ..Instead, they indicate that different "types" of homocysteinemia, or in other words different impairments of nutritional metabolism affecting homocysteine levels, may lead to different end organ dysfunctions and/or diseases...
  37. ncbi Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis Study
    Katherine L Tucker
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Bone Miner Res 20:152-8. 2005
    ..Men with plasma B12 < 148 pM had significantly lower BMD at the hip, and women at the spine, relative to those with higher B12, and trends were similar for both at all sites. Low vitamin B12 may be a risk factor for low BMD...
  38. ncbi Elevated serum methylmalonic acid concentrations are common among elderly Americans
    Martha Savaria Morris
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:2799-803. 2002
    ..We conclude that many elderly Americans demonstrate metabolic evidence of low B-12 status, that elevations occur frequently in the absence of traditional deficiency indicators and that levels vary with race/ethnicity and renal function...
  39. ncbi Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis
    En Pei I Chiang
    Vitamin Metabolism and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Med 114:283-7. 2003
    ..We examined whether these abnormalities are associated with clinical and biochemical indicators of disease status...
  40. pmc Segment-specific association between plasma homocysteine level and carotid artery intima-media thickness in the Framingham Offspring Study
    Marion Dietrich
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Stroke Cerebrovasc Dis 20:155-61. 2011
    ..For CCA-IMT, no significant trends were observed in any of the analyses. The segment-specific association between elevated tHcy level and ICA/bulb-IMT suggests an association between tHcy and plaque formation...
  41. ncbi Folic acid intake from fortification in United States exceeds predictions
    Silvina F Choumenkovitch
    Vitamin Metabolism Laboratory and Nutritional Epidemiology Program, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 132:2792-8. 2002
    ..By these estimations, folic acid fortification resulted in a mean increase in folic acid intake that was approximately twice as large as previously projected...
  42. pmc Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status
    Martha Savaria Morris
    Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 140:103-10. 2010
    ....
  43. pmc A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 90:1623-31. 2009
    ..Evidence from observational studies suggests that inadequate folate status enhances colorectal carcinogenesis, but results from some randomized trials do not support this hypothesis...
  44. pmc The atherogenic effect of excess methionine intake
    Aron M Troen
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 100:15089-94. 2003
    ..Some product of excess methionine metabolism rather than high plasma homocysteine per se may underlie the association of homocysteine with vascular disease...
  45. ncbi A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis
    Joel B Mason
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Cancer Epidemiol Biomarkers Prev 16:1325-9. 2007
    ..Further work is needed to definitively establish the nature of this relationship. In the meantime, deliberations about the institution or enhancement of fortification programs should be undertaken with these considerations in mind...
  46. ncbi Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation
    Lori Lathrop Stern
    Vitamin Metabolism and Aging Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 133:2716-20. 2003
    ..These data are consistent with the current understanding of the molecular interaction of the MTHFR mutant with folate substrates and the FAD prosthetic group...
  47. ncbi Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans
    Martha Savaria Morris
    Nutritional Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University Boston, Tufts JM USDA HNRCA, 711 Washington Street, Room 901D, Boston, MA 02111, USA
    Bone 37:234-42. 2005
    ..Whether this association reflects a causal relation remains unclear and merits further study in light of age-related declines in B12 status and BMD, and the need for low-risk, easily implemented strategies for osteoporosis prevention...
  48. ncbi A prospective study of plasma total cysteine and risk of breast cancer
    Shumin M Zhang
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Epidemiol Biomarkers Prev 12:1188-93. 2003
    ..Cysteine or its precursors might have the potential to be chemopreventive against breast cancer...
  49. pmc Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study
    Eunyoung Cho
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Clin Nutr 83:905-11. 2006
    ..The physiologic relevance of a variation in dietary choline and betaine in the general population and the validity of intake assessed by food-frequency questionnaire (FFQ) have not been evaluated...
  50. doi Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation
    Ligi Paul
    JM USDA HNRC, Tufts University, Boston, Massachusetts 02111, USA
    Nutr Rev 71:239-44. 2013
    ....
  51. ncbi Use of the affinity/HPLC method for quantitative estimation of folic acid in enriched cereal-grain products
    Rosalia Póo-Prieto
    Vitamin Metabolism Laboratory and Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Nutr 136:3079-83. 2006
    ..0 and 5.7% and, run over 5 consecutive days, was 7.2 and 7.3%, respectively. Total folate values in 45 samples of fortified food measured by HPLC and by the traditional microbiological assay demonstrated a high correlation (r(2) = 0.986)...
  52. doi Telomere length in peripheral blood mononuclear cells is associated with folate status in men
    Ligi Paul
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:1273-8. 2009
    ..065) with increased telomere length at below-median folate status. We propose that folate status influences telomere length by affecting DNA integrity and the epigenetic regulation of telomere length through DNA methylation...
  53. ncbi Depression and folate status in the US Population
    Martha S Morris
    Jean Mayer United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Mass, USA
    Psychother Psychosom 72:80-7. 2003
    ..These relationships have not been demonstrated in general populations. This study examined associations between depression and folate status indicators in an ethnically diverse general US population sample aged 15-39 years...
  54. pmc B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice
    Aron M Troen
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    Proc Natl Acad Sci U S A 105:12474-9. 2008
    ..Similar microvascular changes may mediate the association of hyperhomocysteinemia with human age-related cognitive decline...
  55. doi Prediagnostic plasma folate and the risk of death in patients with colorectal cancer
    Brian M Wolpin
    Department of MedicalOncology, Dana Farber Cancer Institute, Boston, MA, USA
    J Clin Oncol 26:3222-8. 2008
    ..Therefore, high priority has been given to research investigating the influence of folate on cancer progression in patients with colorectal cancer...
  56. ncbi Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status
    Robert R McLean
    Research and Training Institute, Hebrew Rehabilitation Center for Aged, Boston, Massachusetts 01702, USA
    J Bone Miner Res 19:410-8. 2004
    ..Our findings support the hypothesis that the association between an MTHFR polymorphism and bone phenotypes depends on folate status...
  57. ncbi Mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folates
    Haifa Ghandour
    Vitamin Metabolism and Aging, Jean Mayer U S D A Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Nutr 134:2975-8. 2004
    ..This altered flux has implications for several common disorders, including cancer and vascular disease...
  58. ncbi Homocysteine as a predictive factor for hip fracture in older persons
    Robert R McLean
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Boston, USA
    N Engl J Med 350:2042-9. 2004
    ..We examined the association between the total homocysteine concentration and the risk of hip fracture in men and women enrolled in the Framingham Study...
  59. ncbi Preliminary evidence shows that folic acid fortification of the food supply is associated with higher methotrexate dosing in patients with rheumatoid arthritis
    Senada Arabelovic
    US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Am Coll Nutr 26:453-5. 2007
    ..However, an increase in dietary folate intake could theoretically reduce the effectiveness of the anti-folate medication, methotrexate (MTX) in treating rheumatoid arthritis (RA) and other inflammatory diseases...
  60. pmc Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community
    Jacob Joseph
    Cardiology Section 111, VA Boston Healthcare System, Boston, Massachusetts, USA
    J Hypertens 27:1317-24. 2009
    ..Hence, we related a panel of biomarkers representing these pathways to plasma markers of collagen metabolism in a large community-based sample...
  61. pmc Micronutrient deficiencies are associated with impaired immune response and higher burden of respiratory infections in elderly Ecuadorians
    Davidson H Hamer
    Jean Mayer USDA Human Nutrition Research Center on the Aging, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA
    J Nutr 139:113-9. 2009
    ..Deficiencies of essential vitamins and minerals place these elderly adults at risk for infections through their negative impact on immune function...
  62. ncbi Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer
    Shumin M Zhang
    Department of Epidemiology, Harvard School of Public Health, Division of Preventive Medicine, Boston, MA 02115, USA
    J Natl Cancer Inst 95:373-80. 2003
    ..However, data relating plasma folate levels to breast cancer risk are sparse. We investigated the association between plasma folate and other vitamins with breast cancer in a prospective, nested case-control study...
  63. ncbi Distribution of plasma folate forms in hemodialysis patients receiving high daily doses of L-folinic or folic acid
    Haifa Ghandour
    Vitamin Metabolism, Jean Mayer United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Kidney Int 62:2246-9. 2002
    ....
  64. ncbi Serum total homocysteine concentrations in children and adolescents: results from the third National Health and Nutrition Examination Survey (NHANES III)
    Aviva Must
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Nutr 133:2643-9. 2003
    ..Improved understanding of the determinants of levels during growth and development may provide important clues to the etiology of adult disease...
  65. ncbi Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study
    Paul F Jacques
    Jean Mayer USDA, Human Nutrition Research Center on Aging at Tufts University, 711 Wasington Street, Boston, MA 02111, USA
    Atherosclerosis 166:49-55. 2003
    ..This study provides no evidence that these common MTR and MTRR mutations are associated with alterations in plasma homocysteine...
  66. ncbi Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins
    Haifa Ghandour
    Vitamin Metabolism, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:1357-60. 2002
    ..568). The importance of these observations is discussed...
  67. ncbi In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific
    Silvina F Choumenkovitch
    Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 132:2157-60. 2002
    ....
  68. ncbi The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene
    Paul F Jacques
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 132:283-8. 2002
    ..Our data suggest that riboflavin status may affect homocysteine metabolism, but only in a small segment of the population who have both low folate status and are homozygotes for the MTHFR C677T mutation...
  69. ncbi The glutamate carboxypeptidase gene II (C>T) polymorphism does not affect folate status in the Framingham Offspring cohort
    Carolina Vargas-Martinez
    The Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:1176-9. 2002
    ..05). Overall, our data show that the GCPII C1561T polymorphism is not a determinant of plasma folate or total homocysteine concentrations in this large cohort of participants from the Framingham Offspring Study...
  70. ncbi Hyperhomocysteinemia in renal transplant recipients
    Allon N Friedman
    Vitamin Metabolism and Aging, Tufts Jean Mayer USDA HNRCA, Boston, MA, USA
    Am J Transplant 2:308-13. 2002
    ..For this reason, RTRs have been chosen as an ideal study population in investigating the effect of reducing hyperhomocysteinemia on CVD outcomes...
  71. ncbi Preconception folate and vitamin B(6) status and clinical spontaneous abortion in Chinese women
    Alayne G Ronnenberg
    Department of Environmental Health, Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Obstet Gynecol 100:107-13. 2002
    ..To assess the association between preconception homocysteine and B vitamin status and risk of clinical spontaneous abortion in women from Anqing, China...
  72. pmc A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 99:5606-11. 2002
    ..03) that is known to be solely represented in those individuals. These results indicate that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status...
  73. ncbi Homocysteine, cysteine, and B vitamins as predictors of kidney disease progression
    Mark J Sarnak
    New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 40:932-9. 2002
    ..Elevated total homocysteine (tHcy) levels and low B vitamin levels are risk factors for atherosclerosis, but have not been evaluated sufficiently as risk factors for the progression of kidney disease...
  74. ncbi A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Anal Chem 74:4526-31. 2002
    ..9 (within-day) and 1.7 (day-to-day). This LC/MS method for quantitative determination of genomic DNA methylation status is rapid, sensitive, selective, and precise...
  75. ncbi Homocysteine and cognitive performance in the Framingham offspring study: age is important
    Merrill F Elias
    The Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA, USA
    Am J Epidemiol 162:644-53. 2005
    ..Early preventive interventions may be important, because the inverse association between tHcy and cognitive performance is observed beyond middle age...
  76. pmc Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet
    Aron M Troen
    Vitamin Metabolism and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA
    Age (Dordr) 29:29-39. 2007
    ..Such defined diets can be used to identify lifespan-modifying pathways and specific gene-nutrient interactions in Drosophila...
  77. ncbi Plasma total homocysteine levels among patients undergoing nocturnal versus standard hemodialysis
    Allon N Friedman
    Vitamin Metabolism and Aging, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Am Soc Nephrol 13:265-8. 2002
    ..Clinical trials will be necessary to confirm that NHD is effective in reducing tHcy levels among patients with dialysis-dependent end-stage renal disease...
  78. ncbi Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status
    En Pei I Chiang
    Vitamin Metabolism and Aging Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 133:1056-9. 2003
    ..420, P = 0.015 and r = 0.333, P = 0.05, respectively). We suggest that in patients with RA, plasma PLP levels are a better diagnostic indicator of functional vitamin B-6 status than erythrocyte PLP levels...
  79. ncbi Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young women
    Steven R Davis
    Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, College of Medicine, University of Florida, Gainesville 32611 0370, USA
    J Nutr 135:1045-50. 2005
    ..In conclusion, elevated homocysteine synthesis is a cause of mild hyperhomocysteinemia in women with marginal folate status, particularly those with the MTHFR 677 T/T genotype...
  80. ncbi Association of a 31 bp VNTR in the CBS gene with postload homocysteine concentrations in the Framingham Offspring Study
    Karin J A Lievers
    Department of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Hum Genet 14:1125-9. 2006
    ..Since also post-methionine load tHcy concentrations are found to be associated with an increased risk for cardiovascular disease (CVD), this 31 bp VNTR may be considered a risk factor for CVD...
  81. ncbi Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model
    Jennifer M Burgoon
    Department of Cell and Developmental Biology, School of Medicine, University of North Carolina, Chapel Hill 27599 7090, USA
    Teratology 65:219-27. 2002
    ..The mechanism(s) by which the vitamin is effective, however, has not been determined. Therefore, a folic acid deficient mouse model was developed...
  82. ncbi Correspondence: will increasing folic acid in fortified grain products further reduce neural tube defects without causing harm?
    Martha Savaria Morris
    Pediatr Res 63:450; author reply 450-1. 2008
  83. ncbi Total homocysteine lowering treatment among coronary artery disease patients in the era of folic acid-fortified cereal grain flour
    Andrew G Bostom
    Division of Renal Diseases, Rhode Island Hospital, Providence 02903, USA
    Arterioscler Thromb Vasc Biol 22:488-91. 2002
    ..These findings have important implications for the statistical power of clinical trials testing the hypothesis that tHcy-lowering treatment may reduce recurrent atherothrombotic event rates...
  84. ncbi Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
    N Engl J Med 346:476-83. 2002
    ..Studies of newly diagnosed dementia are required in order to establish whether the elevated homocysteine levels precede the onset of dementia or result from dementia-related nutritional and vitamin deficiencies...
  85. ncbi Multiple biomarkers and the risk of incident hypertension
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass, USA
    Hypertension 49:432-8. 2007
    ..These data support the premise that abnormalities in multiple biological pathways antedate the onset of overt hypertension...
  86. ncbi Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Pharmacogenetics 12:339-42. 2002
    ..We conclude that the MTHFR 1298A>C polymorphism is a less substantial independent risk factor for colorectal cancer compared to the 677C>T polymorphism...
  87. ncbi The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in women
    Steven R Davis
    Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, College of Medicine, University of Florida, Gainesville, FL 32611 0370, USA
    J Nutr 135:1040-4. 2005
    ....
  88. ncbi Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging
    Deborah M Kado
    Division of Geriatrics, Department of Medicine, The David Geffen School of Medicine at University of California Los Angeles, 90095, USA
    Am J Med 118:161-7. 2005
    ..Further, high homocysteine levels are associated with low vitamin status, and it is unknown whether it is homocysteine toxicity or vitamin insufficiency that is responsible for the observed cognitive dysfunction...
  89. ncbi Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study
    Jia Chen
    Departments of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Cancer 110:617-20. 2004
    ..Findings from our prospective investigation indicate that these newly identified polymorphisms in one-carbon metabolizing genes have limited functionality in modifying folate status and related CRC risk...
  90. ncbi The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr
    Pamela Tran
    Department of Human Genetics, McGill University Montreal Children s Hospital Research Institute, 4060 St Catherine St West, Room 200, QC, Canada
    Mol Genet Metab 76:297-304. 2002
    ....
  91. ncbi Clinical and nutritional correlates of C-reactive protein in type 2 diabetic nephropathy
    Allon N Friedman
    Division of Nephrology, Indiana University School of Medicine, 1481 W 10th St 111N, Indianapolis, IN 46202, USA
    Atherosclerosis 172:121-5. 2004
    ..Patients with diabetic nephropathy are at elevated cardiovascular risk. C-reactive protein (CRP) has been used to successfully predict cardiovascular events...
  92. ncbi Plasma homocysteine, hypertension incidence, and blood pressure tracking: the Framingham Heart Study
    Johan Sundstrom
    Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Hypertension 42:1100-5. 2003
    ....
  93. ncbi Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Site 2, Framingham, MA 01702 5803, USA
    JAMA 289:1251-7. 2003
    ..Elevated plasma homocysteine levels are associated with increased risk of vascular disease. It is unclear whether elevated homocysteine levels are a risk factor for congestive heart failure (CHF)...
  94. ncbi Homocysteine levels and decline in physical function: MacArthur Studies of Successful Aging
    Deborah M Kado
    Division of Geriatrics, Department of Medicine, University of California Los Angeles, 10945 Le Conte Avenue, Los Angeles, CA 90095, USA
    Am J Med 113:537-42. 2002
    ..To test whether elevated homocysteine levels are associated with an increased risk of decline in physical function in older persons...
  95. ncbi Associations of plasma natriuretic peptide, adrenomedullin, and homocysteine levels with alterations in arterial stiffness: the Framingham Heart Study
    Daniel Levy
    NHLBI Framingham Heart Study, Framingham, Mass, USA
    Circulation 115:3079-85. 2007
    ..Little is known about the relations of natriuretic peptides and homocysteine to arterial wall stiffness in the community...

Research Grants7

  1. FOOD FOLATE FORTIFICATION EFFECT ON FOLATE STATUS
    Jacob Selhub; Fiscal Year: 2001
    ..abstract_text> ..
  2. Measurement of folate in fortified cereal grain products
    Jacob Selhub; Fiscal Year: 2003
    ..In order to assess the impact of folic acid fortification, it is necessary to have valid data on the actual synthetic folic acid content of fortified foods. ..
  3. Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring Study
    Jacob Selhub; Fiscal Year: 2009
    ..5 About 3-5 percent of seniors have low circulating vitamin B12 levels;6 however, about 20 percent of seniors are found to be deficient when those with elevated methylmalonic acid levels are included. ..
  4. Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring Study
    Jacob Selhub; Fiscal Year: 2010
    ..5 About 3-5 percent of seniors have low circulating vitamin B12 levels;6 however, about 20 percent of seniors are found to be deficient when those with elevated methylmalonic acid levels are included. ..