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Genomes and Genes | Jacob SelhubSummaryAffiliation: Tufts University Country: USA Publications
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Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritisEn Pei I Chiang
Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, Taiwan 402, Republic of China
Arthritis Res Ther 7:R1404-11. 2005..Data from the present study suggest that patients with rheumatoid arthritis may have higher requirements for vitamin B6 than those in a normal healthy population...- Inflammation causes tissue-specific depletion of vitamin B6En Pei Chiang
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan
Arthritis Res Ther 7:R1254-62. 2005..The low plasma pyridoxal 5'-phosphate levels seen in inflammation are unlikely to be due to insufficient intake or excessive vitamin B6 excretion. Possible causes of decreased levels of vitamin B6 are discussed... 
Public health significance of elevated homocysteineJacob Selhub
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Food Nutr Bull 29:S116-25. 2008..Whether this denominator is homocysteine itself or homocysteine is merely a marker, remains to be determined...- Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiencyJacob Selhub
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 89:702S-6S. 2009.... - The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 statusJacob Selhub
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Food Nutr Bull 29:S67-73. 2008..For serum vitamin B12, the cutoff would be 150 pmol/L based on lowest methylmalonic acid and 300 pmol/L based on lowest homocysteine... - The many facets of hyperhomocysteinemia: studies from the Framingham cohortsJacob Selhub
Vitamin Metabolism and Aging Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 136:1726S-1730S. 2006..Whether this denominator is homocysteine itself or whether homocysteine is merely a marker remains to be determined... - In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrationsJacob Selhub
Vitamin Metabolism Laboratory and Nutritional Epidemiology Program, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 104:19995-20000. 2007..These results suggest a worsening of vitamin B(12)'s enzymatic functions as folate status increases in people who are vitamin B(12)-deficient... 
B vitamins and the aging brainJacob Selhub
Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
Nutr Rev 68:S112-8. 2010..In light of this, it is imperative to find safe ways of improving vitamin B status in the elderly without exposing some individuals to undue risk...- Folic acid fortification: why not vitamin B12 also?Jacob Selhub
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Biofactors 37:269-71. 2011..Hence any food fortification policy that includes folic acid should also include vitamin B12... - Public health significance of supplementation or fortification of grain products with folic acidJacob Selhub
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Food Nutr Bull 29:S173-6. 2008 - Effect of combined folic acid, vitamin B(6), and vitamin B(12) on colorectal adenomaYiqing Song
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
J Natl Cancer Inst 104:1562-75. 2012..Folic acid, vitamin B(6), and vitamin B(12) act in concert in the one-carbon metabolism and may protect against colorectal neoplasia. We examined the effect of combined B-vitamin treatment on the occurrence of colorectal adenoma... - Status of vitamins B-12 and B-6 but not of folate, homocysteine, and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adultsDenish Moorthy
Neuroscience and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
J Nutr 142:1554-60. 2012..The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression... - Cognitive dysfunction and depression in adult kidney transplant recipients: baseline findings from the FAVORIT Ancillary Cognitive Trial (FACT)Aron M Troen
Nutrition and Neurocognition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
J Ren Nutr 22:268-76.e1-3. 2012..Accordingly, we assessed the prevalence of cognitive impairment and depressive symptoms in transplant recipients and their association with kidney function, plasma total homocysteine, and B-vitamin concentrations... - Preconception homocysteine and B vitamin status and birth outcomes in Chinese womenAlayne G Ronnenberg
Departments of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 76:1385-91. 2002..The associations between homocysteine, B vitamin status, and pregnancy outcomes have not been examined prospectively... - Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004Martha Savaria Morris
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 87:1446-54. 2008.... - Plasma vitamin B(6) and risk of myocardial infarction in womenJohn H Page
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Circulation 120:649-55. 2009..We prospectively evaluated the relationships between fasting plasma levels of vitamin B(6), as pyridoxal phosphate, and subsequent myocardial infarction risk in women... - Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniorsMartha Savaria Morris
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 91:1733-44. 2010..However, clinical consequences of vitamin B-12 deficiency may be worsened by high folic acid intakes, perhaps as a direct result of unmetabolized folic acid, which does not occur naturally in body tissues... - Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homocysteine concentrations in the Framingham Offspring Study CohortGiuseppina T Russo
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Nutr 133:3416-21. 2003..001). Our results suggest that age and sex modify the contribution of the MTHFR C677T mutation to fasting tHcy concentrations... - Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in womenJennifer Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Am J Clin Nutr 87:734-43. 2008..B vitamins such as folate, vitamin B-6, and vitamin B-12 are coenzymes that are important for DNA integrity and stability. Deficiency in these B vitamins may promote tumor carcinogenesis... - Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortificationMartha Savaria Morris
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 85:193-200. 2007..This idea is controversial, however, because observational data are few and inconclusive. Furthermore, experimental investigation is unethical... - Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteineAron M Troen
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 138:2502-9. 2008.... - A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folateRenee D Kalmbach
Vitamin Metabolism and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 138:2323-7. 2008..4 nmol/L). Our results suggest the del/del polymorphism in DHFR is a functional polymorphism, because it limits assimilation of folic acid into cellular folate stores at high and low folic acid intakes... - Plasma homocysteine and cysteine and risk of breast cancer in womenJennifer Lin
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer Res 70:2397-405. 2010..The increased risk of breast cancer associated with high cysteine levels warrants further investigation... - Homocysteine in chronic kidney disease: Effect of low protein diet and repletion with B vitaminsVandana Menon
Department of Medicine, Division of Nephrology, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA
Kidney Int 67:1539-46. 2005..There is insufficient evidence to suggest that low tHcy is associated with poor nutritional status in the MDRD Study cohort. B vitamins and GFR, but not dietary protein, are the major determinants of tHcy in this patient population... - Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring StudySudha Seshadri
Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
Arch Neurol 65:642-9. 2008..Elevated plasma total homocysteine (tHcy) levels have been associated with increased risk of dementia and stroke, but it is uncertain whether the mediating mechanisms are predominantly cellular, vascular, or both... - Prospective study of plasma vitamin B6 and risk of colorectal cancer in menJung Eun Lee
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 18:1197-202. 2009..92 (0.55-1.56), 0.42 (0.23-0.75), and 0.49 (0.26-0.92; P(trend) = 0.01), respectively. In conclusion, vitamin B(6) may protect against colorectal cancer independent of other one-carbon metabolites and inflammatory biomarkers... - Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epitheliumSANG WOON CHOI
Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston MA 02111, USA
J Nutr 134:750-5. 2004..05). This vitamin B-12-deficient diet, which was of insufficient severity to cause anemia or illness, created aberrations in both base substitution and methylation of colonic DNA, which might increase susceptibility to carcinogenesis... - Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and womenRobert R McLean
Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
J Clin Endocrinol Metab 93:2206-12. 2008..Elevated homocysteine is a strong risk factor for osteoporotic fractures among elders, yet it may be a marker for low B-vitamin status... - Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adultsLydia Sakakeeny
Vitamin Metabolism Laboratory, Tufts University, Boston, MA, USA
J Nutr 142:1280-5. 2012..We discuss 2 possible roles for PLP in the inflammatory process, including tryptophan metabolism and serine hydroxymethyltransferase activity... - Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trialKatherine L Tucker
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Am J Clin Nutr 79:805-11. 2004..High homocysteine and low B vitamin concentrations have been linked to the risk of vascular disease, stroke, and dementia and are relatively common in older adults... - Relationship between homocysteine and mortality in chronic kidney diseaseVandana Menon
Division of Nephrology, Department of Medicine, Tufts-New England Medical Center, Boston, MA, USA
Circulation 113:1572-7. 2006..Prior studies demonstrating an association between tHcy and CVD risk may have inadequately adjusted for the confounding effects of kidney function... - Plasma vitamin B6 and the risk of colorectal cancer and adenoma in womenEsther K Wei
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Natl Cancer Inst 97:684-92. 2005..However, no previous epidemiologic studies have directly evaluated the association of plasma PLP with risk for colorectal neoplasia... - Uracil misincorporation into DNA and folic acid supplementationAditi Hazra
Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 91:160-5. 2010..Folate deficiency decreases thymidylate synthesis from deoxyuridylate, which results in an imbalance of deoxyribonucleotide that may lead to excessive uracil misincorporation (UrMis) into DNA during replication and repair... - B vitamins and plasma homocysteine concentrations in an urban and rural area of Costa RicaMi Kyung Kim
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Am Coll Nutr 22:224-31. 2003..Because these characteristics are associated with high risk of cardiovascular disease, the efficacy of food fortification program in rural areas should be carefully addressed... - Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation statusMartha Savaria Morris
Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 140:103-10. 2010.... - Genome-wide significant predictors of metabolites in the one-carbon metabolism pathwayAditi Hazra
Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Hum Mol Genet 18:4677-87. 2009..40 x 10(-15)). Genome-wide significant loci were not identified for plasma folate. These data reveal new biological candidates and confirm prior candidate genes for plasma homocysteine, plasma vitamin B12 and plasma PLP... - Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis StudyKatherine L Tucker
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
J Bone Miner Res 20:152-8. 2005..Men with plasma B12 < 148 pM had significantly lower BMD at the hip, and women at the spine, relative to those with higher B12, and trends were similar for both at all sites. Low vitamin B12 may be a risk factor for low BMD... - Elevated serum methylmalonic acid concentrations are common among elderly AmericansMartha Savaria Morris
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr 132:2799-803. 2002..We conclude that many elderly Americans demonstrate metabolic evidence of low B-12 status, that elevations occur frequently in the absence of traditional deficiency indicators and that levels vary with race/ethnicity and renal function... - Folic acid intake from fortification in United States exceeds predictionsSilvina F Choumenkovitch
Vitamin Metabolism Laboratory and Nutritional Epidemiology Program, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 132:2792-8. 2002..By these estimations, folic acid fortification resulted in a mean increase in folic acid intake that was approximately twice as large as previously projected... - Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritisEn-Pei I Chiang
Vitamin Metabolism and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
Am J Med 114:283-7. 2003.... - The cognitive impact of nutritional homocysteinemia in apolipoprotein-E deficient miceAron M Troen
Jean Mayer USDA Human Nutrition Research Centre on Aging, Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
J Alzheimers Dis 9:381-92. 2006..Instead, they indicate that different "types" of homocysteinemia, or in other words different impairments of nutritional metabolism affecting homocysteine levels, may lead to different end organ dysfunctions and/or diseases... - Segment-specific association between plasma homocysteine level and carotid artery intima-media thickness in the Framingham Offspring StudyMarion Dietrich
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
J Stroke Cerebrovasc Dis 20:155-61. 2011..For CCA-IMT, no significant trends were observed in any of the analyses. The segment-specific association between elevated tHcy level and ICA/bulb-IMT suggests an association between tHcy and plaque formation... - A randomized trial on folic acid supplementation and risk of recurrent colorectal adenomaKana Wu
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 90:1623-31. 2009..Evidence from observational studies suggests that inadequate folate status enhances colorectal carcinogenesis, but results from some randomized trials do not support this hypothesis... - Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring StudyEunyoung Cho
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Clin Nutr 83:905-11. 2006..The physiologic relevance of a variation in dietary choline and betaine in the general population and the validity of intake assessed by food-frequency questionnaire (FFQ) have not been evaluated... - A prospective study of plasma total cysteine and risk of breast cancerShumin M Zhang
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer Epidemiol Biomarkers Prev 12:1188-93. 2003..Cysteine or its precursors might have the potential to be chemopreventive against breast cancer... - Relation between homocysteine and B-vitamin status indicators and bone mineral density in older AmericansMartha Savaria Morris
Nutritional Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University Boston, Tufts JM USDA HNRCA, 711 Washington Street, Room 901D, Boston, MA 02111, USA
Bone 37:234-42. 2005..Whether this association reflects a causal relation remains unclear and merits further study in light of age-related declines in B12 status and BMD, and the need for low-risk, easily implemented strategies for osteoporosis prevention... - A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesisJoel B Mason
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Cancer Epidemiol Biomarkers Prev 16:1325-9. 2007..Further work is needed to definitively establish the nature of this relationship. In the meantime, deliberations about the institution or enhancement of fortification programs should be undertaken with these considerations in mind... - The atherogenic effect of excess methionine intakeAron M Troen
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 100:15089-94. 2003..Some product of excess methionine metabolism rather than high plasma homocysteine per se may underlie the association of homocysteine with vascular disease... - Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutationLori Lathrop Stern
Vitamin Metabolism and Aging Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 133:2716-20. 2003..These data are consistent with the current understanding of the molecular interaction of the MTHFR mutant with folate substrates and the FAD prosthetic group... - Preliminary evidence shows that folic acid fortification of the food supply is associated with higher methotrexate dosing in patients with rheumatoid arthritisSenada Arabelovic
US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
J Am Coll Nutr 26:453-5. 2007..However, an increase in dietary folate intake could theoretically reduce the effectiveness of the anti-folate medication, methotrexate (MTX) in treating rheumatoid arthritis (RA) and other inflammatory diseases... - Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate statusRobert R McLean
Research and Training Institute, Hebrew Rehabilitation Center for Aged, Boston, Massachusetts 01702, USA
J Bone Miner Res 19:410-8. 2004..Our findings support the hypothesis that the association between an MTHFR polymorphism and bone phenotypes depends on folate status... - Use of the affinity/HPLC method for quantitative estimation of folic acid in enriched cereal-grain productsRosalia Póo-Prieto
Vitamin Metabolism Laboratory and Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
J Nutr 136:3079-83. 2006..0 and 5.7% and, run over 5 consecutive days, was 7.2 and 7.3%, respectively. Total folate values in 45 samples of fortified food measured by HPLC and by the traditional microbiological assay demonstrated a high correlation (r(2) = 0.986)... - Homocysteine as a predictive factor for hip fracture in older personsRobert R McLean
Hebrew Rehabilitation Center for Aged Research and Training Institute, Boston, USA
N Engl J Med 350:2042-9. 2004..We examined the association between the total homocysteine concentration and the risk of hip fracture in men and women enrolled in the Framingham Study... - Mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folatesHaifa Ghandour
Vitamin Metabolism and Aging, Jean Mayer U S D A Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
J Nutr 134:2975-8. 2004..This altered flux has implications for several common disorders, including cancer and vascular disease... - Prediagnostic plasma folate and the risk of death in patients with colorectal cancerBrian M Wolpin
Department of MedicalOncology, Dana Farber Cancer Institute, Boston, MA, USA
J Clin Oncol 26:3222-8. 2008..Therefore, high priority has been given to research investigating the influence of folate on cancer progression in patients with colorectal cancer... - Depression and folate status in the US PopulationMartha S Morris
Jean Mayer United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Mass, USA
Psychother Psychosom 72:80-7. 2003..These relationships have not been demonstrated in general populations. This study examined associations between depression and folate status indicators in an ethnically diverse general US population sample aged 15-39 years... - B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in miceAron M Troen
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
Proc Natl Acad Sci U S A 105:12474-9. 2008..Similar microvascular changes may mediate the association of hyperhomocysteinemia with human age-related cognitive decline... - Telomere length in peripheral blood mononuclear cells is associated with folate status in menLigi Paul
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 139:1273-8. 2009..065) with increased telomere length at below-median folate status. We propose that folate status influences telomere length by affecting DNA integrity and the epigenetic regulation of telomere length through DNA methylation... - Micronutrient deficiencies are associated with impaired immune response and higher burden of respiratory infections in elderly EcuadoriansDavidson H Hamer
Jean Mayer USDA Human Nutrition Research Center on the Aging, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA
J Nutr 139:113-9. 2009..Deficiencies of essential vitamins and minerals place these elderly adults at risk for infections through their negative impact on immune function... - Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the communityJacob Joseph
Cardiology Section 111, VA Boston Healthcare System, Boston, Massachusetts, USA
J Hypertens 27:1317-24. 2009..Hence, we related a panel of biomarkers representing these pathways to plasma markers of collagen metabolism in a large community-based sample... - Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancerShumin M Zhang
Department of Epidemiology, Harvard School of Public Health, Division of Preventive Medicine, Boston, MA 02115, USA
J Natl Cancer Inst 95:373-80. 2003..However, data relating plasma folate levels to breast cancer risk are sparse. We investigated the association between plasma folate and other vitamins with breast cancer in a prospective, nested case-control study... - The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase genePaul F Jacques
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 132:283-8. 2002..Our data suggest that riboflavin status may affect homocysteine metabolism, but only in a small segment of the population who have both low folate status and are homozygotes for the MTHFR C677T mutation... - The glutamate carboxypeptidase gene II (C>T) polymorphism does not affect folate status in the Framingham Offspring cohortCarolina Vargas-Martinez
The Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr 132:1176-9. 2002..05). Overall, our data show that the GCPII C1561T polymorphism is not a determinant of plasma folate or total homocysteine concentrations in this large cohort of participants from the Framingham Offspring Study... - Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteinsHaifa Ghandour
Vitamin Metabolism, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr 132:1357-60. 2002..568). The importance of these observations is discussed... - Distribution of plasma folate forms in hemodialysis patients receiving high daily doses of L-folinic or folic acidHaifa Ghandour
Vitamin Metabolism, Jean Mayer United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
Kidney Int 62:2246-9. 2002..CONCLUSIONS: Data from the present findings suggest that defects in folate absorption or impairment in folate interconversion are not the cause of the persistent hyperhomocysteinemia in hemodialysis patients... - Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart StudyPaul F Jacques
Jean Mayer USDA, Human Nutrition Research Center on Aging at Tufts University, 711 Wasington Street, Boston, MA 02111, USA
Atherosclerosis 166:49-55. 2003..This study provides no evidence that these common MTR and MTRR mutations are associated with alterations in plasma homocysteine... - Serum total homocysteine concentrations in children and adolescents: results from the third National Health and Nutrition Examination Survey (NHANES III)Aviva Must
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
J Nutr 133:2643-9. 2003..Improved understanding of the determinants of levels during growth and development may provide important clues to the etiology of adult disease... - In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specificSilvina F Choumenkovitch
Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 132:2157-60. 2002.... - Hyperhomocysteinemia in renal transplant recipientsAllon N Friedman
Vitamin Metabolism and Aging, Tufts Jean Mayer USDA HNRCA, Boston, MA, USA
Am J Transplant 2:308-13. 2002..For this reason, RTRs have been chosen as an ideal study population in investigating the effect of reducing hyperhomocysteinemia on CVD outcomes... - Preconception folate and vitamin B(6) status and clinical spontaneous abortion in Chinese womenAlayne G Ronnenberg
Department of Environmental Health, Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Obstet Gynecol 100:107-13. 2002..To assess the association between preconception homocysteine and B vitamin status and risk of clinical spontaneous abortion in women from Anqing, China... - Homocysteine, cysteine, and B vitamins as predictors of kidney disease progressionMark J Sarnak
New England Medical Center, Boston, MA 02111, USA
Am J Kidney Dis 40:932-9. 2002..Elevated total homocysteine (tHcy) levels and low B vitamin levels are risk factors for atherosclerosis, but have not been evaluated sufficiently as risk factors for the progression of kidney disease... - A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate statusSimonetta Friso
Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 99:5606-11. 2002..03) that is known to be solely represented in those individuals. These results indicate that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status... - Homocysteine and cognitive performance in the Framingham offspring study: age is importantMerrill F Elias
The Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA, USA
Am J Epidemiol 162:644-53. 2005..Early preventive interventions may be important, because the inverse association between tHcy and cognitive performance is observed beyond middle age... - Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined dietAron M Troen
Vitamin Metabolism and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA
Age (Dordr) 29:29-39. 2007..Such defined diets can be used to identify lifespan-modifying pathways and specific gene-nutrient interactions in Drosophila... - A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometrySimonetta Friso
Vitamin Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research on Aging at Tufts University, Boston, Massachusetts 02111, USA
Anal Chem 74:4526-31. 2002..9 (within-day) and 1.7 (day-to-day). This LC/MS method for quantitative determination of genomic DNA methylation status is rapid, sensitive, selective, and precise... - Plasma total homocysteine levels among patients undergoing nocturnal versus standard hemodialysisAllon N Friedman
Vitamin Metabolism and Aging, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
J Am Soc Nephrol 13:265-8. 2002..Clinical trials will be necessary to confirm that NHD is effective in reducing tHcy levels among patients with dialysis-dependent end-stage renal disease... - Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 statusEn-Pei I Chiang
Vitamin Metabolism and Aging Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 133:1056-9. 2003..420, P = 0.015 and r = 0.333, P = 0.05, respectively). We suggest that in patients with RA, plasma PLP levels are a better diagnostic indicator of functional vitamin B-6 status than erythrocyte PLP levels... - Correspondence: will increasing folic acid in fortified grain products further reduce neural tube defects without causing harm?Martha Savaria Morris
Pediatr Res 63:450; author reply 450-1. 2008 - Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse modelJennifer M Burgoon
Department of Cell and Developmental Biology, School of Medicine, University of North Carolina, Chapel Hill 27599-7090, USA
Teratology 65:219-27. 2002..Thus, an excellent model has been created to investigate the mechanism(s) underlying the origin of birth defects related to folic acid deficiency... - Total homocysteine lowering treatment among coronary artery disease patients in the era of folic acid-fortified cereal grain flourAndrew G Bostom
Division of Renal Diseases, Rhode Island Hospital, Providence 02903, USA
Arterioscler Thromb Vasc Biol 22:488-91. 2002..These findings have important implications for the statistical power of clinical trials testing the hypothesis that tHcy-lowering treatment may reduce recurrent atherothrombotic event rates... - Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancerJia Chen
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
Pharmacogenetics 12:339-42. 2002..We conclude that the MTHFR 1298A>C polymorphism is a less substantial independent risk factor for colorectal cancer compared to the 677C>T polymorphism... - Plasma homocysteine as a risk factor for dementia and Alzheimer's diseaseSudha Seshadri
Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
N Engl J Med 346:476-83. 2002..Studies of newly diagnosed dementia are required in order to establish whether the elevated homocysteine levels precede the onset of dementia or result from dementia-related nutritional and vitamin deficiencies... - Multiple biomarkers and the risk of incident hypertensionThomas J Wang
Framingham Heart Study, Framingham, Mass, USA
Hypertension 49:432-8. 2007..These data support the premise that abnormalities in multiple biological pathways antedate the onset of overt hypertension... - Association of a 31 bp VNTR in the CBS gene with postload homocysteine concentrations in the Framingham Offspring StudyKarin J A Lievers
Department of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur J Hum Genet 14:1125-9. 2006..Since also post-methionine load tHcy concentrations are found to be associated with an increased risk for cardiovascular disease (CVD), this 31 bp VNTR may be considered a risk factor for CVD... - The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in MthfrPamela Tran
Department of Human Genetics, McGill University Montreal Children s Hospital Research Institute, 4060 St Catherine St West, Room 200, QC, Canada
Mol Genet Metab 76:297-304. 2002.... - Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective studyJia Chen
Departments of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Int J Cancer 110:617-20. 2004..Findings from our prospective investigation indicate that these newly identified polymorphisms in one-carbon metabolizing genes have limited functionality in modifying folate status and related CRC risk... - Clinical and nutritional correlates of C-reactive protein in type 2 diabetic nephropathyAllon N Friedman
Division of Nephrology, Indiana University School of Medicine, 1481 W 10th St 111N, Indianapolis, IN 46202, USA
Atherosclerosis 172:121-5. 2004..Patients with diabetic nephropathy are at elevated cardiovascular risk. C-reactive protein (CRP) has been used to successfully predict cardiovascular events... - Plasma homocysteine, hypertension incidence, and blood pressure tracking: the Framingham Heart StudyJohan Sundstrom
Framingham Heart Study, Framingham, Mass 01702 5803, USA
Hypertension 42:1100-5. 2003.... - The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in womenSteven R Davis
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, College of Medicine, University of Florida, Gainesville, FL 32611 0370, USA
J Nutr 135:1040-4. 2005.... - Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarctionRamachandran S Vasan
National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Site 2, Framingham, MA 01702 5803, USA
JAMA 289:1251-7. 2003..Elevated plasma homocysteine levels are associated with increased risk of vascular disease. It is unclear whether elevated homocysteine levels are a risk factor for congestive heart failure (CHF)... - Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young womenSteven R Davis
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, College of Medicine, University of Florida, Gainesville 32611 0370, USA
J Nutr 135:1045-50. 2005..In conclusion, elevated homocysteine synthesis is a cause of mild hyperhomocysteinemia in women with marginal folate status, particularly those with the MTHFR 677 T/T genotype... - Homocysteine levels and decline in physical function: MacArthur Studies of Successful AgingDeborah M Kado
Division of Geriatrics, Department of Medicine, University of California Los Angeles, 10945 Le Conte Avenue, Los Angeles, CA 90095, USA
Am J Med 113:537-42. 2002..To test whether elevated homocysteine levels are associated with an increased risk of decline in physical function in older persons... - Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful AgingDeborah M Kado
Division of Geriatrics, Department of Medicine, The David Geffen School of Medicine at University of California Los Angeles, 90095, USA
Am J Med 118:161-7. 2005..Further, high homocysteine levels are associated with low vitamin status, and it is unknown whether it is homocysteine toxicity or vitamin insufficiency that is responsible for the observed cognitive dysfunction... - Associations of plasma natriuretic peptide, adrenomedullin, and homocysteine levels with alterations in arterial stiffness: the Framingham Heart StudyDaniel Levy
NHLBI Framingham Heart Study, Framingham, Mass, USA
Circulation 115:3079-85. 2007..Little is known about the relations of natriuretic peptides and homocysteine to arterial wall stiffness in the community...
Research Grants
- FOOD FOLATE FORTIFICATION EFFECT ON FOLATE STATUSJacob Selhub; Fiscal Year: 2001..abstract_text> ..
- Measurement of folate in fortified cereal grain productsJacob Selhub; Fiscal Year: 2003..In order to assess the impact of folic acid fortification, it is necessary to have valid data on the actual synthetic folic acid content of fortified foods. ..
- Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring StudyJacob Selhub; Fiscal Year: 2009..5 About 3-5 percent of seniors have low circulating vitamin B12 levels;6 however, about 20 percent of seniors are found to be deficient when those with elevated methylmalonic acid levels are included. ..
- Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring StudyJacob Selhub; Fiscal Year: 2010..5 About 3-5 percent of seniors have low circulating vitamin B12 levels;6 however, about 20 percent of seniors are found to be deficient when those with elevated methylmalonic acid levels are included. ..