J Selhub

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Folate, vitamin B12 and vitamin B6 and one carbon metabolism
    J Selhub
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr Health Aging 6:39-42. 2002
  2. ncbi request reprint Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification
    J Selhub
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Public Health Rev 28:117-45. 2000
  3. ncbi request reprint B vitamins, homocysteine, and neurocognitive function in the elderly
    J Selhub
    Jean Mayer US Department of Agriculture Human Nutrition Research Centeron Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 71:614S-620S. 2000
  4. ncbi request reprint Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort
    P F Jacques
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 73:613-21. 2001
  5. ncbi request reprint Hyperhomocysteinemia and hypercholesterolemia associated with hypothyroidism in the third US National Health and Nutrition Examination Survey
    M S Morris
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 155:195-200. 2001
  6. ncbi request reprint Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels
    S Friso
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Circulation 103:2788-91. 2001
  7. ncbi request reprint Total homocysteine and estrogen status indicators in the Third National Health and Nutrition Examination Survey
    M S Morris
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Epidemiol 152:140-8. 2000
  8. ncbi request reprint Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians
    J Ma
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 94:2410-6. 1996
  9. ncbi request reprint Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism
    P M Ridker
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 95:1777-82. 1997
  10. ncbi request reprint Nonfasting plasma total homocysteine levels and all-cause and cardiovascular disease mortality in elderly Framingham men and women
    A G Bostom
    Tufts Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, Mass, USA
    Arch Intern Med 159:1077-80. 1999

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Folate, vitamin B12 and vitamin B6 and one carbon metabolism
    J Selhub
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr Health Aging 6:39-42. 2002
    ..We need more studies to confirm that these vitamins have important functions in the etiology of these diseases. We also need to establish if these diseases can be prevented or diminished by proper nutrition starting at a younger age...
  2. ncbi request reprint Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification
    J Selhub
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Public Health Rev 28:117-45. 2000
    ..The impact of fortification on the US population is likely to be similar; however it awaits the next survey for further confirmation...
  3. ncbi request reprint B vitamins, homocysteine, and neurocognitive function in the elderly
    J Selhub
    Jean Mayer US Department of Agriculture Human Nutrition Research Centeron Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 71:614S-620S. 2000
    ....
  4. ncbi request reprint Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort
    P F Jacques
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 73:613-21. 2001
    ..Established determinants of fasting total homocysteine (tHcy) concentration include folate and vitamin B-12 status, serum creatinine concentration, and renal function...
  5. ncbi request reprint Hyperhomocysteinemia and hypercholesterolemia associated with hypothyroidism in the third US National Health and Nutrition Examination Survey
    M S Morris
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 155:195-200. 2001
    ..Hyperhomocysteinemia and hypercholesterolemia could help to explain the increased risk for arteriosclerotic coronary artery disease in hypothyroidism...
  6. ncbi request reprint Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels
    S Friso
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Circulation 103:2788-91. 2001
    ..This observation may reflect a vitamin B(6) utilization in the presence of an underlying inflammatory process and represent a possible mechanism to explain the decreased vitamin B(6) levels in CVD...
  7. ncbi request reprint Total homocysteine and estrogen status indicators in the Third National Health and Nutrition Examination Survey
    M S Morris
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Epidemiol 152:140-8. 2000
    ....
  8. ncbi request reprint Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians
    J Ma
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 94:2410-6. 1996
    ..A common mutation in MTHFR recently has been identified...
  9. ncbi request reprint Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism
    P M Ridker
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 95:1777-82. 1997
    ....
  10. ncbi request reprint Nonfasting plasma total homocysteine levels and all-cause and cardiovascular disease mortality in elderly Framingham men and women
    A G Bostom
    Tufts Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, Mass, USA
    Arch Intern Med 159:1077-80. 1999
    ..We examined whether elevated fasting plasma tHcy levels were predictive of all-cause and CVD mortality in a large, population-based sample of elderly US women and men...
  11. ncbi request reprint Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey
    P F Jacques
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 69:482-9. 1999
    ..The elevation of circulating total homocysteine concentrations in a fasting state is associated with an increased risk of occlusive vascular disease...
  12. ncbi request reprint Folic acid fortification increases red blood cell folate concentrations in the Framingham study
    S F Choumenkovitch
    Vitamin Metabolism and Aging Laboratory, and Epidemiology Program, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 131:3277-80. 2001
    ..The results of this study showed that in this cohort, the introduction of folic acid fortification significantly improved folate nutritional status measured as RBC folate...
  13. ncbi request reprint Serum cystatin C is an independent predictor of total homocysteine levels in stable Korean renal transplant recipients with normal serum creatinine
    H Han
    Frances Stern Nutrition Center, New England Medical Center, Boston, MA 02111, USA
    J Ren Nutr 11:149-54. 2001
    ..4 mg/dl)...
  14. ncbi request reprint Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey
    M S Morris
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 73:927-33. 2001
    ..Blood homocysteine concentrations are inversely correlated with performance on some cognitive-function tests and a relation was recently shown between hyperhomocysteinemia and Alzheimer disease...
  15. ncbi request reprint Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study
    J B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 24:1403-10. 2001
    ..We examined relationships between homocysteine levels and features of insulin resistance syndrome (IRS)...
  16. ncbi request reprint Effect of L-dopa on plasma homocysteine in PD patients: relationship to B-vitamin status
    J W Miller
    Vitamin Bioavailability Lab, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Neurology 60:1125-9. 2003
    ..This effect of L-dopa on plasma homocysteine is accentuated under conditions of impaired homocysteine metabolism such as folate deficiency...
  17. ncbi request reprint Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring study
    K L Tucker
    Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston MA 02111, USA
    Am J Clin Nutr 71:514-22. 2000
    ..Low vitamin B-12 status is prevalent among the elderly, but few studies have examined the association between vitamin B-12 status and intake...
  18. ncbi request reprint The kidney and homocysteine metabolism
    A N Friedman
    Vitamin Metabolism and Aging, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Am Soc Nephrol 12:2181-9. 2001
    ..Efforts to resolve this important issue will advance the search for effective Hcy-lowering therapies in patients with renal disease...
  19. pmc A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells
    P J Bagley
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 95:13217-20. 1998
    ....
  20. ncbi request reprint Effect of vitamin B-6 deficiency on fasting plasma homocysteine concentrations
    J W Miller
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111
    Am J Clin Nutr 55:1154-60. 1992
    ..It is concluded that fasting plasma homocysteine concentrations are not initially elevated in vitamin B-6 deficiency and therefore fasting plasma homocysteine concentrations are not a good indicator of vitamin B-6 status...
  21. pmc The relation of plasma homocysteine to radiographic knee osteoarthritis
    M Fayfman
    Boston University School of Medicine, Boston, USA
    Osteoarthritis Cartilage 17:766-71. 2009
    ..In the present study we considered the possible relationship between plasma homocysteine levels and the development and progression of knee osteoarthritis (OA)...
  22. ncbi request reprint Homocysteine metabolism
    J Selhub
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Annu Rev Nutr 19:217-46. 1999
    ..The studies with animal models indicated the possibility that the effect of elevated homocysteine is multifactorial, affecting both the vascular wall structure and the blood coagulation system...
  23. ncbi request reprint Analysis of folate form distribution by affinity followed by reversed- phase chromatography with electrical detection
    P J Bagley
    Vitamin Metabolism Laboratory, US Department of Agriculture Jean Mayer Human Nutrition Research Centeron Aging at Tufts University, Boston, MA 02111, USA
    Clin Chem 46:404-11. 2000
    ..The ability to measure these folate coenzymes in tissues and cells gives important information about in vivo folate metabolism...
  24. ncbi request reprint Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Atherosclerosis 154:667-72. 2001
    ..It was concluded that influence of the MS (D919G) polymorphism on the plasma tHcy and folate levels is at most moderate, but should be further investigated in other large prospective studies...
  25. ncbi request reprint Elevated serum homocysteine levels and increased risk of invasive cervical cancer in US women
    S J Weinstein
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cancer Causes Control 12:317-24. 2001
    ..CONCLUSIONS: Serum homocysteine was strongly and significantly predictive of invasive cervical cancer risk. This association could reflect folate, B12 and/or B6 inadequacy, or genetic polymorphisms affecting one-carbon metabolism...
  26. ncbi request reprint Renal insufficiency, vitamin B(12) status, and population attributable risk for mild hyperhomocysteinemia among coronary artery disease patients in the era of folic acid-fortified cereal grain flour
    G Liaugaudas
    Division of General Internal Medicine, Memorial Hospital of Rhode Island, Providence, USA
    Arterioscler Thromb Vasc Biol 21:849-51. 2001
    ..5%). In the era of folic acid-fortified cereal grain flour, renal insufficiency and suboptimal vitamin B(12) status (but not folate status) contribute importantly to the PAR for mild hyperhomocysteinemia among patients with stable CAD...
  27. ncbi request reprint Association of the B-vitamins pyridoxal 5'-phosphate (B(6)), B(12), and folate with lung cancer risk in older men
    T J Hartman
    Department of Nutrition, The Pennsylvania State University, University Park, PA, USA
    Am J Epidemiol 153:688-94. 2001
    ..This is the first report from a prospectively conducted study to suggest a role for vitamin B(6) in lung cancer...
  28. ncbi request reprint COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk
    J E Goodman
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Carcinogenesis 22:1661-5. 2001
    ..05) or above median levels of homocysteine (P(trend) = 0.02). These findings are consistent with a role for certain folate pathway micronutrients in mediating the association between COMT genotype and breast cancer risk...
  29. ncbi request reprint Rapid communication: L-folinic acid versus folic acid for the treatment of hyperhomocysteinemia in hemodialysis patients
    A Yango
    Division of Renal Diseases, Rhode Island Hospital, Providence, Rhode Island, USA
    Kidney Int 59:324-7. 2001
    ..The preponderance of hemodialysis patients (that is,> 90%) exhibits mild hyperhomocysteinemia refractory to treatment with either regimen...