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Species | J SelhubSummaryAffiliation: Tufts University Country: USA Publications
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Publications
Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortificationJ Selhub
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
Public Health Rev 28:117-45. 2000..The impact of fortification on the US population is likely to be similar; however it awaits the next survey for further confirmation...- Folate, vitamin B12 and vitamin B6 and one carbon metabolismJ Selhub
JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Nutr Health Aging 6:39-42. 2002..We need more studies to confirm that these vitamins have important functions in the etiology of these diseases. We also need to establish if these diseases can be prevented or diminished by proper nutrition starting at a younger age... - B vitamins, homocysteine, and neurocognitive function in the elderlyJ Selhub
Jean Mayer US Department of Agriculture Human Nutrition Research Centeron Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 71:614S-620S. 2000.... - Determinants of plasma total homocysteine concentration in the Framingham Offspring cohortP F Jacques
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
Am J Clin Nutr 73:613-21. 2001..Established determinants of fasting total homocysteine (tHcy) concentration include folate and vitamin B-12 status, serum creatinine concentration, and renal function... - Hyperhomocysteinemia and hypercholesterolemia associated with hypothyroidism in the third US National Health and Nutrition Examination SurveyM S Morris
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Atherosclerosis 155:195-200. 2001..Hyperhomocysteinemia and hypercholesterolemia could help to explain the increased risk for arteriosclerotic coronary artery disease in hypothyroidism... - Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levelsS Friso
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Circulation 103:2788-91. 2001..This observation may reflect a vitamin B(6) utilization in the presence of an underlying inflammatory process and represent a possible mechanism to explain the decreased vitamin B(6) levels in CVD... - Total homocysteine and estrogen status indicators in the Third National Health and Nutrition Examination SurveyM S Morris
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Am J Epidemiol 152:140-8. 2000.... - Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physiciansJ Ma
Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
Circulation 94:2410-6. 1996..A common mutation in MTHFR recently has been identified... - Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolismP M Ridker
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Circulation 95:1777-82. 1997.... - Nonfasting plasma total homocysteine levels and all-cause and cardiovascular disease mortality in elderly Framingham men and womenA G Bostom
Tufts Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, Mass, USA
Arch Intern Med 159:1077-80. 1999..We examined whether elevated fasting plasma tHcy levels were predictive of all-cause and CVD mortality in a large, population-based sample of elderly US women and men... - Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination SurveyP F Jacques
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 69:482-9. 1999..The elevation of circulating total homocysteine concentrations in a fasting state is associated with an increased risk of occlusive vascular disease... - Folic acid fortification increases red blood cell folate concentrations in the Framingham studyS F Choumenkovitch
Vitamin Metabolism and Aging Laboratory, and Epidemiology Program, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 131:3277-80. 2001..The results of this study showed that in this cohort, the introduction of folic acid fortification significantly improved folate nutritional status measured as RBC folate... - Serum cystatin C is an independent predictor of total homocysteine levels in stable Korean renal transplant recipients with normal serum creatinineH Han
Frances Stern Nutrition Center, New England Medical Center, Boston, MA 02111, USA
J Ren Nutr 11:149-54. 2001..4 mg/dl)... - Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination SurveyM S Morris
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 73:927-33. 2001..Blood homocysteine concentrations are inversely correlated with performance on some cognitive-function tests and a relation was recently shown between hyperhomocysteinemia and Alzheimer disease... - Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring studyJ B Meigs
General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Diabetes Care 24:1403-10. 2001..We examined relationships between homocysteine levels and features of insulin resistance syndrome (IRS)... - Effect of L-dopa on plasma homocysteine in PD patients: relationship to B-vitamin statusJ W Miller
Vitamin Bioavailability Lab, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
Neurology 60:1125-9. 2003..This effect of L-dopa on plasma homocysteine is accentuated under conditions of impaired homocysteine metabolism such as folate deficiency... - Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring studyK L Tucker
Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston MA 02111, USA
Am J Clin Nutr 71:514-22. 2000..Low vitamin B-12 status is prevalent among the elderly, but few studies have examined the association between vitamin B-12 status and intake... - The kidney and homocysteine metabolismA N Friedman
Vitamin Metabolism and Aging, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
J Am Soc Nephrol 12:2181-9. 2001..Efforts to resolve this important issue will advance the search for effective Hcy-lowering therapies in patients with renal disease... 
A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cellsP J Bagley
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 95:13217-20. 1998....- Effect of vitamin B-6 deficiency on fasting plasma homocysteine concentrationsJ W Miller
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111
Am J Clin Nutr 55:1154-60. 1992..It is concluded that fasting plasma homocysteine concentrations are not initially elevated in vitamin B-6 deficiency and therefore fasting plasma homocysteine concentrations are not a good indicator of vitamin B-6 status... - The relation of plasma homocysteine to radiographic knee osteoarthritisM Fayfman
Boston University School of Medicine, Boston, USA
Osteoarthritis Cartilage 17:766-71. 2009..In the present study we considered the possible relationship between plasma homocysteine levels and the development and progression of knee osteoarthritis (OA)... - Homocysteine metabolismJ Selhub
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
Annu Rev Nutr 19:217-46. 1999..The studies with animal models indicated the possibility that the effect of elevated homocysteine is multifactorial, affecting both the vascular wall structure and the blood coagulation system... - Analysis of folate form distribution by affinity followed by reversed- phase chromatography with electrical detectionP J Bagley
Vitamin Metabolism Laboratory, US Department of Agriculture Jean Mayer Human Nutrition Research Centeron Aging at Tufts University, Boston, MA 02111, USA
Clin Chem 46:404-11. 2000..The ability to measure these folate coenzymes in tissues and cells gives important information about in vivo folate metabolism... - Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarctionJ Chen
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Atherosclerosis 154:667-72. 2001..It was concluded that influence of the MS (D919G) polymorphism on the plasma tHcy and folate levels is at most moderate, but should be further investigated in other large prospective studies... - Elevated serum homocysteine levels and increased risk of invasive cervical cancer in US womenS J Weinstein
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Cancer Causes Control 12:317-24. 2001..CONCLUSIONS: Serum homocysteine was strongly and significantly predictive of invasive cervical cancer risk. This association could reflect folate, B12 and/or B6 inadequacy, or genetic polymorphisms affecting one-carbon metabolism... - Renal insufficiency, vitamin B(12) status, and population attributable risk for mild hyperhomocysteinemia among coronary artery disease patients in the era of folic acid-fortified cereal grain flourG Liaugaudas
Division of General Internal Medicine, Memorial Hospital of Rhode Island, Providence, USA
Arterioscler Thromb Vasc Biol 21:849-51. 2001..5%). In the era of folic acid-fortified cereal grain flour, renal insufficiency and suboptimal vitamin B(12) status (but not folate status) contribute importantly to the PAR for mild hyperhomocysteinemia among patients with stable CAD... - Association of the B-vitamins pyridoxal 5'-phosphate (B(6)), B(12), and folate with lung cancer risk in older menT J Hartman
Department of Nutrition, The Pennsylvania State University, University Park, PA, USA
Am J Epidemiol 153:688-94. 2001..This is the first report from a prospectively conducted study to suggest a role for vitamin B(6) in lung cancer... - COMT genotype, micronutrients in the folate metabolic pathway and breast cancer riskJ E Goodman
Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
Carcinogenesis 22:1661-5. 2001..05) or above median levels of homocysteine (P(trend) = 0.02). These findings are consistent with a role for certain folate pathway micronutrients in mediating the association between COMT genotype and breast cancer risk... - Rapid communication: L-folinic acid versus folic acid for the treatment of hyperhomocysteinemia in hemodialysis patientsA Yango
Division of Renal Diseases, Rhode Island Hospital, Providence, Rhode Island, USA
Kidney Int 59:324-7. 2001..The preponderance of hemodialysis patients (that is,> 90%) exhibits mild hyperhomocysteinemia refractory to treatment with either regimen...