ERNST SCHAEFER

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. pmc Effects of Therapeutic Lifestyle Change diets high and low in dietary fish-derived FAs on lipoprotein metabolism in middle-aged and elderly subjects
    Esther M M Ooi
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 53:1958-67. 2012
  2. doi request reprint Effects of cholesteryl ester transfer protein inhibitors on human lipoprotein metabolism: why have they failed in lowering coronary heart disease risk?
    Ernst J Schaefer
    Lipid Metabolism Laboratory, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 24:259-64. 2013
  3. ncbi request reprint Should we target HDL-cholesterol to reduce coronary heart disease risk?
    Ernst J Schaefer
    Cardiovascular Research Laboratory, Tufts University School of Medicine, Boston, MA 02111, USA
    Nat Clin Pract Endocrinol Metab 2:358-9. 2006
  4. ncbi request reprint The effects of statins on high-density lipoproteins
    Ernst J Schaefer
    Cardiovascular Research Laboratory, Tufts University School of Medicine, Boston, MA 02111, USA
    Curr Atheroscler Rep 8:41-9. 2006
  5. ncbi request reprint Increasing high-density lipoprotein cholesterol, inhibition of cholesteryl ester transfer protein, and heart disease risk reduction
    Ernst J Schaefer
    Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University, Boston, Massachusetts 02111, USA
    Am J Cardiol 100:n25-31. 2007
  6. ncbi request reprint Cholesteryl ester transfer protein inhibition, high-density lipoprotein metabolism and heart disease risk reduction
    Ernst J Schaefer
    Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University, Boston, Massachusetts, USA
    Curr Opin Lipidol 17:394-8. 2006
  7. ncbi request reprint Where are we with high-density lipoprotein raising and inhibition of cholesteryl ester transfer for heart disease risk reduction?
    Ernst J Schaefer
    Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Cardiol 22:373-8. 2007
  8. pmc Dietary fructose and glucose differentially affect lipid and glucose homeostasis
    Ernst J Schaefer
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Cardiovascular Research Laboratory, Friedman School of Nutrition Science and Policy, Tufts University School of Medicine, Boston, MA 02111, USA
    J Nutr 139:1257S-1262S. 2009
  9. ncbi request reprint The effects of low-fat, high-carbohydrate diets on plasma lipoproteins, weight loss, and heart disease risk reduction
    Ernst J Schaefer
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Curr Atheroscler Rep 7:421-7. 2005
  10. ncbi request reprint Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study
    Ernst J Schaefer
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tuffs University, Boston, MA 02111, USA
    Arch Neurol 63:1545-50. 2006

Research Grants

Collaborators

Detail Information

Publications100

  1. pmc Effects of Therapeutic Lifestyle Change diets high and low in dietary fish-derived FAs on lipoprotein metabolism in middle-aged and elderly subjects
    Esther M M Ooi
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 53:1958-67. 2012
    ..Both diets decreased LDL apoB-100 concentration by increasing LDL apoB-100 FCR and decreased HDL apoA-I concentration by decreasing HDL apoA-I PR...
  2. doi request reprint Effects of cholesteryl ester transfer protein inhibitors on human lipoprotein metabolism: why have they failed in lowering coronary heart disease risk?
    Ernst J Schaefer
    Lipid Metabolism Laboratory, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 24:259-64. 2013
    ..To examine the recent advances in our knowledge of cholesteryl ester transfer protein (CETP) inhibitors, heart disease risk reduction, and human lipoprotein metabolism...
  3. ncbi request reprint Should we target HDL-cholesterol to reduce coronary heart disease risk?
    Ernst J Schaefer
    Cardiovascular Research Laboratory, Tufts University School of Medicine, Boston, MA 02111, USA
    Nat Clin Pract Endocrinol Metab 2:358-9. 2006
  4. ncbi request reprint The effects of statins on high-density lipoproteins
    Ernst J Schaefer
    Cardiovascular Research Laboratory, Tufts University School of Medicine, Boston, MA 02111, USA
    Curr Atheroscler Rep 8:41-9. 2006
    ....
  5. ncbi request reprint Increasing high-density lipoprotein cholesterol, inhibition of cholesteryl ester transfer protein, and heart disease risk reduction
    Ernst J Schaefer
    Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University, Boston, Massachusetts 02111, USA
    Am J Cardiol 100:n25-31. 2007
    ..Another alternative for increasing HDL levels is to develop more effective and better tolerated niacin preparations...
  6. ncbi request reprint Cholesteryl ester transfer protein inhibition, high-density lipoprotein metabolism and heart disease risk reduction
    Ernst J Schaefer
    Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University, Boston, Massachusetts, USA
    Curr Opin Lipidol 17:394-8. 2006
    ....
  7. ncbi request reprint Where are we with high-density lipoprotein raising and inhibition of cholesteryl ester transfer for heart disease risk reduction?
    Ernst J Schaefer
    Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Cardiol 22:373-8. 2007
    ..To review recent research in the area of high-density lipoprotein raising and coronary heart disease risk reduction...
  8. pmc Dietary fructose and glucose differentially affect lipid and glucose homeostasis
    Ernst J Schaefer
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Cardiovascular Research Laboratory, Friedman School of Nutrition Science and Policy, Tufts University School of Medicine, Boston, MA 02111, USA
    J Nutr 139:1257S-1262S. 2009
    ....
  9. ncbi request reprint The effects of low-fat, high-carbohydrate diets on plasma lipoproteins, weight loss, and heart disease risk reduction
    Ernst J Schaefer
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Curr Atheroscler Rep 7:421-7. 2005
    ....
  10. ncbi request reprint Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study
    Ernst J Schaefer
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tuffs University, Boston, MA 02111, USA
    Arch Neurol 63:1545-50. 2006
    ..Docosahexaenoic acid (DHA) is an abundant fatty acid in the brain. In the diet, DHA is found mostly in fatty fish. The content of DHA has been shown to be decreased in the brain and plasma of patients with dementia...
  11. ncbi request reprint Effects of atorvastatin versus other statins on fasting and postprandial C-reactive protein and lipoprotein-associated phospholipase A2 in patients with coronary heart disease versus control subjects
    Ernst J Schaefer
    Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University School of Medicine, Friedman School of Nutrition Science and Policy at Tufts University, Boston, Massachusetts 02111, USA
    Am J Cardiol 95:1025-32. 2005
    ....
  12. doi request reprint Marked HDL deficiency and premature coronary heart disease
    Ernst J Schaefer
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 21:289-97. 2010
    ..Our purpose is to review recent publications in the area of marked human HDL deficiency, HDL particles, coronary heart disease (CHD), amyloidosis, the immune response, and kidney disease...
  13. pmc Substitution of vegetable oil for a partially-hydrogenated fat favorably alters cardiovascular disease risk factors in moderately hypercholesterolemic postmenopausal women
    Sonia Vega-Lopez
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
    Atherosclerosis 207:208-12. 2009
    ..Acceptable alternatives must be adjudicated. Our objective was to assess the effect of a recent commercial fat substitution, corn oil for partially-hydrogenated soybean oil...
  14. ncbi request reprint A promoter polymorphism in cholesterol 7alpha-hydroxylase interacts with apolipoprotein E genotype in the LDL-lowering response to atorvastatin
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, USA
    Atherosclerosis 180:407-15. 2005
    ..We concluded that the CYP7A1 A-204C promoter variant was associated with poor response to atorvastatin, which were additively enhanced by common variants in another locus, APOE...
  15. pmc Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Endocrinol (Oxf) 72:169-75. 2010
    ..Subjects Postmenopausal Caucasian women (n = 208) participating in a placebo-controlled randomized trial of 3.2 years of hormone therapy (HT)...
  16. ncbi request reprint Gender-specific effects of estrogen receptor alpha gene haplotype on high-density lipoprotein cholesterol response to atorvastatin: interaction with apolipoprotein AI gene polymorphism
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, MA, USA
    Atherosclerosis 178:331-8. 2005
    ....
  17. ncbi request reprint The L162V polymorphism at the peroxisome proliferator activated receptor alpha locus modulates the risk of cardiovascular events associated with insulin resistance and diabetes mellitus: the Veterans Affairs HDL Intervention Trial (VA-HIT)
    E Shyong Tai
    Nutrition and Genomics Unit, Jean Mayer USDA Human Nutrition Research Center for Aging at Tufts University, Boston, MA, USA
    Atherosclerosis 187:153-60. 2006
    ..We hypothesized that the association between a functional polymorphism at the PPARA locus (L162V) and the risk of a CV event, as well as response to fibrate therapy, might be greatest in those with either IR or DM (DM/IR) in VA-HIT...
  18. ncbi request reprint ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, MA, USA
    J Lipid Res 45:653-6. 2004
    ..These results suggest that, in patients with hypercholesterolemia, the ABCG8 D19H variant is associated with greater LDLC-lowering response to atorvastatin therapy...
  19. ncbi request reprint Interrelationships between human apolipoprotein A-I and apolipoproteins B-48 and B-100 kinetics using stable isotopes
    Francine K Welty
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 24:1703-7. 2004
    ..Our purpose was to determine the relationship between apolipoprotein (apo) A-I and apoB-48 and apoB-100 metabolism in moderately hypercholesterolemic humans...
  20. doi request reprint Effects of intensive atorvastatin and rosuvastatin treatment on apolipoprotein B-48 and remnant lipoprotein cholesterol levels
    Seiko Otokozawa
    Cardiovascular Research Laboratory, Friedman School of Nutrition Science and Policy at Tufts University and Tufts University School of Medicine, Boston, MA 02111, USA
    Atherosclerosis 205:197-201. 2009
    ..Our findings utilizing a specific immunoassay and a fairly large number of subjects extend prior studies indicating that statins significantly lower apolipoprotein B containing lipoproteins of both intestinal and liver origin...
  21. ncbi request reprint Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study
    E Shyong Tai
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
    J Nutr 135:397-403. 2005
    ..Our data show that the effect of the L162V polymorphism on plasma TG and apoC-III concentrations depends on the dietary PUFA, with a high intake triggering lower TG in carriers of the 162V allele...
  22. ncbi request reprint Effects of estrogen and medroxyprogesterone acetate on subpopulations of triglyceride-rich lipoproteins and high-density lipoproteins
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory and the Biostatistics Unit, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Metabolism 52:1330-6. 2003
    ....
  23. ncbi request reprint Interactions between common genetic polymorphisms in ABCG5/G8 and CYP7A1 on LDL cholesterol-lowering response to atorvastatin
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, MA, USA
    Atherosclerosis 175:287-93. 2004
    ..The other ABCG5/G8 polymorphisms did not show any significant interactions with the CYP7A1 polymorphism. We conclude that the ABCG8 H19 and CYP7A1 C-204 alleles appear to interact in a dose-dependent manner on atorvastatin response...
  24. ncbi request reprint Gender-specific association of a perilipin gene haplotype with obesity risk in a white population
    Lu Qi
    Nutrition and Genomics Laboratories, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Obes Res 12:1758-65. 2004
    ..Our purpose was to examine the association between common single-nucleotide polymorphisms (SNPs) at the perilipin (PLIN) locus and obesity, as well as related phenotypes, in unrelated American adults...
  25. pmc Effects of cholesteryl ester transfer protein inhibition on apolipoprotein A-II-containing HDL subspecies and apolipoprotein A-II metabolism
    Margaret E Brousseau
    Cardiovascular Research Laboratory, Tufts University School of Medicine, Boston, MA, USA
    J Lipid Res 50:1456-62. 2009
    ..Our findings indicate that CETP inhibition increases plasma concentrations of apoA-II by delaying HDL apoA-II catabolism and significantly alters the remodeling of apoA-II-containing HDL subpopulations...
  26. doi request reprint Fasting and postprandial apolipoprotein B-48 levels in healthy, obese, and hyperlipidemic subjects
    Seiko Otokozawa
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 58:1536-42. 2009
    ..Median apo B-48 values in healthy subjects are about 0.5 mg/dL and increase more than 100% in the fed state. Elevated levels are observed in obese and hyperlipidemic subjects...
  27. ncbi request reprint CYP3A4 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin in primary hypercholesterolemia
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 93:104-7. 2004
    ....
  28. pmc Sex hormone modulation of proinflammatory cytokine and C-reactive protein expression in macrophages from older men and postmenopausal women
    Michael P Corcoran
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Endocrinol 206:217-24. 2010
    ..Our results indicate that testosterone may exert anti-inflammatory effects by reducing macrophage TNF-alpha expression, while the effects of estrogen on macrophage CRP expression may depend upon the extracellular lipid environment...
  29. ncbi request reprint Risk of cardiovascular disease in a cohort of HIV-infected adults: a study using carotid intima-media thickness and coronary artery calcium score
    Alexandra Mangili
    Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
    Clin Infect Dis 43:1482-9. 2006
    ..We measured 2 surrogate markers of subclinical atherosclerosis, carotid intima-media thickness (c-IMT) and coronary artery calcium (CAC) scores, in HIV-infected adults...
  30. ncbi request reprint Effect of hydrogenated and saturated, relative to polyunsaturated, fat on immune and inflammatory responses of adults with moderate hypercholesterolemia
    Sung Nim Han
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Lipid Res 43:445-52. 2002
    ....
  31. doi request reprint Effects of maximal doses of atorvastatin versus rosuvastatin on small dense low-density lipoprotein cholesterol levels
    Masumi Ai
    Cardiovascular Research Laboratory, Friedman School of Nutrition Science and Policy at Tufts University, Boston, Massachusetts, USA
    Am J Cardiol 101:315-8. 2008
    ....
  32. ncbi request reprint Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the framingham study
    Doreen Osgood
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 88:2869-79. 2003
    ..03 for interaction). Similar results were obtained for HDL(2)-C. In conclusion, SR-BI gene variation modulates the lipid profile, particularly in type 2 diabetes, contributing to the metabolic abnormalities in these subjects...
  33. doi request reprint Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER
    Eliana Polisecki
    Cardiovascular Research and Lipid Metabolism Laboratories, Friedman School of Nutrition Science and Policy, Tufts University School of Medicine and the Jean Mayer USDA Human Nutrition Research Center at Tufts University, Boston, MA USA
    Atherosclerosis 200:109-14. 2008
    ..Our data indicate that genetic variation at the LDLR locus can affect baseline lipids, response to pravastatin, and CVD risk in subjects placed on statin treatment...
  34. pmc Altering dietary lysine:arginine ratio has little effect on cardiovascular risk factors and vascular reactivity in moderately hypercholesterolemic adults
    Sonia Vega-Lopez
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Atherosclerosis 210:555-62. 2010
    ..Information is scarce regarding the effect of dietary protein type, with specific focus on the lysine-to-arginine (Lys:Arg) ratio, on cardiovascular risk factors and vascular reactivity in humans...
  35. ncbi request reprint Men and women differ in lipoprotein response to dietary saturated fat and cholesterol restriction
    Zhengling Li
    Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:3428-33. 2003
    ..These data are consistent with the concept that middle aged/elderly men may have a more favorable lipoprotein response to a low fat, low cholesterol diet than postmenopausal women...
  36. ncbi request reprint The metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein (a) in human beings
    Jennifer L Jenner
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Metabolism 54:361-9. 2005
    ....
  37. pmc Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial
    Nirupa R Matthan
    Cardiovascular Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 51:202-9. 2010
    ..The magnitude of these alterations were similar between cases and controls and do not explain differences in outcomes with pravastatin treatment...
  38. pmc Role of the estrogen and progestin in hormonal replacement therapy on apolipoprotein A-I kinetics in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 26:385-91. 2006
    ..Hormonal replacement therapy (HRT) affects plasma HDL cholesterol levels, with estrogen increasing HDL cholesterol levels and progestins blunting this effect. This study was designed to assess the mechanism responsible for these effects...
  39. ncbi request reprint Role of LCAT in HDL remodeling: investigation of LCAT deficiency states
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:592-9. 2007
    ....
  40. ncbi request reprint Value of high-density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, HNRCA, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 25:2185-91. 2005
    ....
  41. pmc Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD
    Nirupa R Matthan
    Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 50:1927-35. 2009
    ..These data suggest that impaired cholesterol homeostasis, reflected by lower synthesis and higher absorption marker concentrations, are highly significant independent predictors of prevalent CVD in this study population...
  42. ncbi request reprint LpA-I, LpA-I:A-II HDL and CHD-risk: The Framingham Offspring Study and the Veterans Affairs HDL Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, JM USDA HNRCA, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 188:59-67. 2006
    ..We tested the hypothesis that concentrations of LpA-I and/or LpA-I:A-II HDL subclasses are significantly associated with CHD prevalence and recurrent cardiovascular events...
  43. pmc Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway
    Thomas M van Himbergen
    Lipid Metabolism Laboratory, Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    Arterioscler Thromb Vasc Biol 30:113-20. 2010
    ..In light of prior metabolic and genetic research, our purpose was to ascertain whether FCH cases had significant abnormalities of plasma markers of cholesterol synthesis and absorption as compared to unaffected kindred members...
  44. pmc Extended-release niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and ApoB-containing lipoproteins
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:1672-8. 2008
    ..Extended-release niacin effectively lowers plasma TG levels and raises plasma high-density lipoprotein (HDL) cholesterol levels, but the mechanisms responsible for these effects are unclear...
  45. doi request reprint Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population
    Eliana Polisecki
    Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Atherosclerosis 200:95-101. 2008
    ..Our data support the concept that the rare allele of the R46L SNP at the PCSK9 locus significantly lowers LDL C, but does not greatly reduce CHD risk in an elderly population with a high prevalence of cardiovascular disease...
  46. pmc Relation of gemfibrozil treatment and high-density lipoprotein subpopulation profile with cardiovascular events in the Veterans Affairs High-Density Lipoprotein Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 57:77-83. 2008
    ..It is quite possible that much of the cardiovascular benefits of gemfibrozil are due to a much wider spectrum of effects on metabolic processes that is not reflected by changes in blood lipids and HDL subpopulations...
  47. ncbi request reprint Novel soybean oils with different fatty acid profiles alter cardiovascular disease risk factors in moderately hyperlipidemic subjects
    Alice H Lichtenstein
    Cardiovascular Nutrition Laboratory and the Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 84:497-504. 2006
    ..A variety of soybean oils were developed with improved oxidative stability and functional characteristics for use as alternatives to partially hydrogenated fat...
  48. ncbi request reprint Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:1746-53. 2007
    ..Atorvastatin-mediated changes in cholesterol homeostasis may contribute to apoB PR regulation...
  49. ncbi request reprint Comparison of the effects of high doses of rosuvastatin versus atorvastatin on the subpopulations of high-density lipoproteins
    Bela F Asztalos
    Cardiovascular Research Laboratory, Tufts University, Boston, Massachusetts, USA
    Am J Cardiol 99:681-5. 2007
    ..In conclusion, our data show that both statins, given at their maximal doses, favorably alter the HDL subpopulation profile, but also that rosuvastatin is significantly more effective in this regard than atorvastatin...
  50. ncbi request reprint High-density lipoprotein subpopulation profile and coronary heart disease prevalence in male participants of the Framingham Offspring Study
    Bela F Asztalos
    Lipid Metabolism Laboratory, HNRCA at Tufts University, 711 Washington Street, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 24:2181-7. 2004
    ..We tested the hypothesis whether specific HDL subpopulations are significantly associated with CHD-prevalence...
  51. ncbi request reprint Protease inhibitor-based HAART, HDL, and CHD-risk in HIV-infected patients
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging, Tufts University, Boston, MA 02111, USA
    Atherosclerosis 184:72-7. 2006
    ....
  52. ncbi request reprint Polyunsaturated fatty acids modulate the effects of the APOA1 G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the Framingham Study
    Jose M Ordovas
    Nutrition and Genomics Laboratory, the Lipid Metabolism Laboratory and the Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston 02111, USA
    Am J Clin Nutr 75:38-46. 2002
    ..The A allele was shown to be associated with higher HDL-cholesterol concentrations in some studies but not in others...
  53. ncbi request reprint Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects
    Alice H Lichtenstein
    Cardiovascular Nutrition Laboratory and Lipid Metabolism Laboratory, JM HNRC Human Nutrition Research Center on Aging at Tufts University, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 22:1852-8. 2002
    ..The objective of this study was to assess the independent effect of soy relative to common sources of animal protein and soy-derived isoflavones on blood lipids...
  54. ncbi request reprint New targets for medical treatment of lipid disorders
    Margaret E Brousseau
    JM USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Curr Atheroscler Rep 4:343-9. 2002
    ....
  55. ncbi request reprint Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 45:448-55. 2004
    ....
  56. ncbi request reprint Comparisons of effects of statins (atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin) on fasting and postprandial lipoproteins in patients with coronary heart disease versus control subjects
    Ernst J Schaefer
    Atherosclerosis Research Laboratory, Lipid and Heart Disease Prevention Clinic, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Cardiol 93:31-9. 2004
    ....
  57. ncbi request reprint Effect of hormonal replacement therapy on C-reactive protein and cell-adhesion molecules in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Am J Cardiol 91:252-4. 2003
  58. ncbi request reprint Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol
    Margaret E Brousseau
    Lipid Research Laboratory, Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    N Engl J Med 350:1505-15. 2004
    ..Inhibition of cholesteryl ester transfer protein (CETP) has been proposed as a strategy to raise HDL cholesterol levels...
  59. ncbi request reprint Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston Mass 02111, USA
    Arterioscler Thromb Vasc Biol 24:1092-7. 2004
    ....
  60. ncbi request reprint Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects
    Alice H Lichtenstein
    Cardiovascular Nutrition Research Program and Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Lipid Res 43:264-73. 2002
    ..Female and male subjects responded similarly. The TLC/Step 2 diet resulted in a decrease in some CVD risk factors and no apparent adverse effects in others...
  61. ncbi request reprint Association of apo A-IV 360 (Gln --> His) polymorphism with plasma lipids and lipoproteins: the Framingham Offspring Study
    Maysa S Cendoroglo
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 179:169-75. 2005
    ..In conclusion, the apo A-IV-2 allele is associated with a modest reduction in plasma triglyceride levels in the general population...
  62. ncbi request reprint TRL, IDL, and LDL apolipoprotein B-100 and HDL apolipoprotein A-I kinetics as a function of age and menopausal status
    Nirupa R Matthan
    Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 25:1691-6. 2005
    ..To determine mechanisms contributing to the altered lipoprotein profile associated with aging and menopause, apolipoprotein B-100 (apoB-100) and apoA-I kinetic behavior was assessed...
  63. ncbi request reprint Lipoproteins, nutrition, and heart disease
    Ernst J Schaefer
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 75:191-212. 2002
    ....
  64. ncbi request reprint Differences in serum sex hormone and plasma lipid levels in Caucasian and African-American premenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 90:4516-20. 2005
    ..Risk of coronary heart disease is higher in African-American than in Caucasian women...
  65. pmc Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion
    Margaret E Brousseau
    Lipid Metabolism Laboratory, JM USDA HNRCA at Tufts University and Tufts New England Medical Center, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 25:1057-64. 2005
    ..The present study was designed to address these issues...
  66. ncbi request reprint Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 46:2246-53. 2005
    ..Cholesterol efflux via the SR-BI pathway is associated with several HDL subpopulations with different apolipoprotein composition, lipid content, and size...
  67. ncbi request reprint Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and women in the Framingham Offspring Study
    Ernst J Schaefer
    Lipid Research Laboratory, Division of Endocrinology, Diabetes, Metabolism, and Molecular Medicine, New England Medical Center, Boston, Massachusetts 02111, USA
    Diabetes Care 25:989-94. 2002
    ..We hypothesized that diabetic patients would have higher remnant levels than nondiabetic patients...
  68. pmc Effect of hormone replacement therapy on plasma lipoprotein levels and coronary atherosclerosis progression in postmenopausal women according to type 2 diabetes mellitus status
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 59:1794-800. 2010
    ..Faster progression of coronary atherosclerosis in women with diabetes could be mediated in part by a worse lipoprotein profile in these women than in women without diabetes, both before and during HRT...
  69. ncbi request reprint Potential role of dietary n-3 fatty acids in the prevention of dementia and macular degeneration
    Elizabeth J Johnson
    Carotenoid and Health and Lipid Metabolism Laboratories, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 83:1494S-1498S. 2006
    ..7 fish servings/wk) is associated with an approximately 50% reduction in dementia risk. At least this amount of DHA is generally found in one commercially available 1-g fish oil capsule given daily...
  70. ncbi request reprint High-density lipoprotein subpopulations in pathologic conditions
    Bela F Asztalos
    Atherosclerosis Research Laboratory, New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 91:12E-17E. 2003
    ..A new statin, rosuvastatin, produces greater increases in HDL cholesterol than atorvastatin, but its effect on HDL particle distribution is yet to be determined...
  71. ncbi request reprint Dietary and plasma lipid, lipoprotein, and apolipoprotein profiles among elderly Hispanics and non-Hispanics and their association with diabetes
    Odilia I Bermudez
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:1214-21. 2002
    ..There are limited data about dietary intakes and plasma lipids of elderly US Hispanics...
  72. pmc Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women
    Bela F Asztalos
    Lipid Metabolism Laboratory, Human Nutrition Research Center at Tufts University, Boston, MA, USA
    J Lipid Res 51:2405-12. 2010
    ..05) concentrations. These results demonstrate beneficial changes in HDL remodeling following substantial weight loss induced by RYGBP surgery and that these changes are associated with improvement of glucose homeostasis in these patients...
  73. pmc Changes in remnant and high-density lipoproteins associated with hormone therapy and progression of coronary artery disease in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
    Atherosclerosis 205:325-30. 2009
    ....
  74. ncbi request reprint Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Mass 02111, USA
    Circulation 106:2315-21. 2002
    ..This allele has been associated with decreased HL activity and increased HDL-C concentrations. However, the effect is variable among populations...
  75. ncbi request reprint Effects of atorvastatin on the HDL subpopulation profile of coronary heart disease patients
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 43:1701-7. 2002
    ....
  76. ncbi request reprint Effects of atorvastatin on fasting and postprandial lipoprotein subclasses in coronary heart disease patients versus control subjects
    Ernst J Schaefer
    Atherosclerosis Research Laboratory, Lipid and Heart Disease Prevention Clinic, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 90:689-96. 2002
    ..001) by this treatment. Our data indicate that atorvastatin treatment normalizes levels of all classes of triglyceride-rich lipoproteins and LDL in both the fasting and fed states in patients with CHD compared with control subjects...
  77. ncbi request reprint Comparing the effects of five different statins on the HDL subpopulation profiles of coronary heart disease patients
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University and Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center, Boston, MA 02111, USA
    Atherosclerosis 164:361-9. 2002
    ..The order of efficacy of statins in increasing alpha-1 HDL subpopulation was: atorvastatin, simvastatin, pravastatin, lovastatin and fluvastatin...
  78. pmc Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly
    Eliana Polisecki
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 51:1201-7. 2010
    ..The -133 A>G polymorphism and not other variants was associated with 6 month LDL-C lowering (P = 0.02). Our data indicate that variation in the NPC1L1 gene is associated with plasma total and LDL-C levels and CHD risk...
  79. doi request reprint Plasma levels of HDL subpopulations and remnant lipoproteins predict the extent of angiographically-defined coronary artery disease in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:575-9. 2008
    ..The association of coronary heart disease (CHD) with subpopulations of triglyceride (TG)-rich lipoproteins and high-density lipoproteins (HDL) is established in men, but has not been well characterized in women...
  80. ncbi request reprint Cholesteryl ester transfer protein TaqI B2B2 genotype is associated with higher HDL cholesterol levels and lower risk of coronary heart disease end points in men with HDL deficiency: Veterans Affairs HDL Cholesterol Intervention Trial
    Margaret E Brousseau
    Lipid Metabolism Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University and Department of Medicine, New England Medical Center, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 22:1148-54. 2002
    ..The present study was undertaken to further define the relationship between this polymorphism and CHD risk at the population level...
  81. pmc Gender-specific differences in the kinetics of nonfasting TRL, IDL, and LDL apolipoprotein B-100 in men and premenopausal women
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:1838-43. 2008
    ..To investigate mechanisms underlying gender differences in serum lipoprotein concentrations, the kinetic behavior of apoB-100 was assessed...
  82. ncbi request reprint Polymorphisms in the gene encoding lipoprotein lipase in men with low HDL-C and coronary heart disease: the Veterans Affairs HDL Intervention Trial
    Margaret E Brousseau
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, and Department of Medicine, New England Medical Center, Boston, MA, USA
    J Lipid Res 45:1885-91. 2004
    ....
  83. ncbi request reprint Plasma lipid and lipoprotein levels during the follicular and luteal phases of the menstrual cycle
    Junaidah B Barnett
    Nutrition Infection Unit, Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 89:776-82. 2004
    ..Studies involving premenopausal women need to more clearly define and validate menstrual cycle phase in the design and interpretation of study results...
  84. ncbi request reprint HDL in atherosclerosis: actor or bystander?
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, and Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center, Boston, MA 02111, USA
    Atheroscler Suppl 4:21-9. 2003
    ..The cholesterol in HDL can either be transferred to apolipoprotein B-containing particles via CETP or delivered directly to the liver with the help of scavenger receptor B1...
  85. pmc Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers
    Thomas M van Himbergen
    Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 50:730-9. 2009
    ..In addition, alterations in absolute values of plasma sterols correlated with the cholesterol lowering response...
  86. ncbi request reprint Change in alpha1 HDL concentration predicts progression in coronary artery stenosis
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University and Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 23:847-52. 2003
    ..We examined the effects of simvastatin-niacin and antioxidant vitamins on changes in high-density lipoprotein (HDL) subpopulations and alterations in coronary artery stenosis, as assessed by angiography...
  87. ncbi request reprint Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Lipid Res 44:800-6. 2003
    ..26, P < 0.005) and negatively associated with a percent change in beta-sitosterol (r = -0.21, P < 0.01). These data suggest that changes in stenosis were attributable, in part, to changes in cholesterol metabolism...
  88. ncbi request reprint Importance of dietary management and practical patient counseling--US perspective
    Ernst J Schaefer
    Tufts University Schools of Medicine and Nutrition Science and Policy, Lipid and Heart Disease Prevention Clinic, New England Medical Center, Boston, MA 02111, USA
    Atheroscler Suppl 3:17-22. 2002
  89. ncbi request reprint Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial
    James D Otvos
    LipoScience, Inc, Raleigh, NC, USA
    Circulation 113:1556-63. 2006
    ..We examined whether measurement of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle subclasses provides additional information relative to CHD risk reduction...
  90. ncbi request reprint Sex and age differences in lipoprotein subclasses measured by nuclear magnetic resonance spectroscopy: the Framingham Study
    David S Freedman
    Division of Nutrition and Physical Activity, CDC, Atlanta, GA, USA
    Clin Chem 50:1189-200. 2004
    ..We examined whether this differential CHD risk might, in part, be attributable to the sizes of lipoprotein particles or concentrations of lipoprotein subclasses...
  91. ncbi request reprint Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on apolipoprotein B100 metabolism in humans
    John S Millar
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Arterioscler Thromb Vasc Biol 26:1350-6. 2006
    ..The goal of the present study was to define the kinetic mechanism(s) by which CETP inhibition reduces levels of apoB-containing lipoproteins...
  92. ncbi request reprint Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Framingham Heart Study
    Sekar Kathiresan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circulation 113:20-9. 2006
    ..However, the atherogenic potential of LDL may depend on the number and size of LDL particles in addition to the cholesterol content of LDL...
  93. ncbi request reprint Lipoprotein metabolism in subjects with hepatic lipase deficiency
    Marju Tilly-Kiesi
    Helsinki University Central Hospital, Helsinki, Finland
    Metabolism 53:520-5. 2004
    ..HL deficiency may result in a lipoprotein pattern associated with low heart disease risk...
  94. ncbi request reprint Hypertriglyceridemia and cardiovascular risk reduction
    Terry A Jacobson
    Office of Health Promotion and Disease Prevention, Emory University, Atlanta, GA 30303, USA
    Clin Ther 29:763-77. 2007
    ..There is evidence that elevated TG levels may be a significant independent risk factor for coronary heart disease (CHD), particularly in women...
  95. ncbi request reprint Clinical utility of different lipid measures for prediction of coronary heart disease in men and women
    Erik Ingelsson
    Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702 5803
    JAMA 298:776-85. 2007
    ..Evidence is conflicting regarding the performance of apolipoproteins vs traditional lipids for predicting coronary heart disease (CHD) risk...
  96. ncbi request reprint Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on VLDL apolipoprotein E metabolism
    John S Millar
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Lipid Res 49:543-9. 2008
    ..Adding torcetrapib to atorvastatin treatment increases the VLDL apoE content, likely leading to decreased conversion of VLDL to LDL, reduced LDL production, and lower levels of circulating VLDL and LDL...
  97. ncbi request reprint Insulin resistance and cardiovascular events with low HDL cholesterol: the Veterans Affairs HDL Intervention Trial (VA-HIT)
    Sander J Robins
    Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Diabetes Care 26:1513-7. 2003
    ....
  98. ncbi request reprint Importance of high-density lipoprotein cholesterol and triglyceride levels in coronary heart disease
    Dennis L Sprecher
    Am J Cardiol 91:575-80. 2003
  99. ncbi request reprint Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT)
    Hanna Bloomfield Rubins
    Section of General Internal Medicine 111O, Veterans Affairs Medical Center, 1 Veterans Dr, Minneapolis, MN 55417
    Arch Intern Med 162:2597-604. 2002
    ..Diabetes mellitus, impaired fasting glucose level, or insulin resistance are associated with increased risk of cardiovascular disease...
  100. ncbi request reprint Unique lipoprotein phenotype and genotype associated with exceptional longevity
    Nir Barzilai
    Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, NY 10461, USA
    JAMA 290:2030-40. 2003
    ..Individuals with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility...

Research Grants17

  1. Pharmacogenetics of the Statin Response
    ERNST SCHAEFER; Fiscal Year: 2006
    ..These results can be used to formulate guidelines for identifying elderly subjects for statin treatment to prevent future CHD. ..
  2. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2003
    ..abstract_text> ..
  3. MOLECULAR BASIS OF HIGH DENSITY LIPOPROTEIN DEFICIENCY
    ERNST SCHAEFER; Fiscal Year: 2001
    ..This research will provide us with important information about the role of LPL mutations in the determination of low plasma HDL-C concentrations. ..
  4. MOLECULAR BASIS OF HIGH DENSITY LIPOPROTEIN DEFICIENCY
    ERNST SCHAEFER; Fiscal Year: 2009
    ..The results of this work will provide important insight into the contribution of allelic variation in the pathways of HDL metabolism, inflammation, and insulin resistance to the complex phenotype of low HDL-C. ..