E J Schaefer

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Lipoproteins, nutrition, and heart disease
    Ernst J Schaefer
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 75:191-212. 2002
  2. ncbi request reprint Comparison of fasting and postprandial plasma lipoproteins in subjects with and without coronary heart disease
    E J Schaefer
    Lipid and Heart Disease Prevention Program, New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 88:1129-33. 2001
  3. ncbi request reprint Cholesterol and apolipoprotein B metabolism in Tangier disease
    E J Schaefer
    Lipid Metabolism Laboratory, Department of Medicine, New England Medical Center, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 159:231-6. 2001
  4. ncbi request reprint Effects of atorvastatin on fasting and postprandial lipoprotein subclasses in coronary heart disease patients versus control subjects
    Ernst J Schaefer
    Atherosclerosis Research Laboratory, Lipid and Heart Disease Prevention Clinic, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 90:689-96. 2002
  5. ncbi request reprint Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and women in the Framingham Offspring Study
    Ernst J Schaefer
    Lipid Research Laboratory, Division of Endocrinology, Diabetes, Metabolism, and Molecular Medicine, New England Medical Center, Boston, Massachusetts 02111, USA
    Diabetes Care 25:989-94. 2002
  6. ncbi request reprint Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in the Framingham Offspring Study
    J R Galluzzi
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 159:417-24. 2001
  7. ncbi request reprint Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study
    J M Ordovas
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Arterioscler Thromb Vasc Biol 20:1323-9. 2000
  8. ncbi request reprint Remnant-like particle (RLP) cholesterol is an independent cardiovascular disease risk factor in women: results from the Framingham Heart Study
    J R McNamara
    Lipid Research Laboratory, New England Medical Center, 750 Washington Street, Box 216, Boston, MA 02111, USA
    Atherosclerosis 154:229-36. 2001
  9. ncbi request reprint Remnant lipoprotein cholesterol and triglyceride reference ranges from the Framingham Heart Study
    J R McNamara
    Division of Endocrinology, Diabetes, Metabolism, and Molecular Medicine, New England Medical Center, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Chem 44:1224-32. 1998
  10. pmc Substitution of vegetable oil for a partially-hydrogenated fat favorably alters cardiovascular disease risk factors in moderately hypercholesterolemic postmenopausal women
    Sonia Vega-Lopez
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
    Atherosclerosis 207:208-12. 2009

Collaborators

Detail Information

Publications125 found, 100 shown here

  1. ncbi request reprint Lipoproteins, nutrition, and heart disease
    Ernst J Schaefer
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 75:191-212. 2002
    ....
  2. ncbi request reprint Comparison of fasting and postprandial plasma lipoproteins in subjects with and without coronary heart disease
    E J Schaefer
    Lipid and Heart Disease Prevention Program, New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 88:1129-33. 2001
    ..Thus, a feeding challenge is not essential for assessment of these lipoproteins. Moreover, it is not necessary to obtain a fasting sample to assess direct LDL and HDL cholesterol...
  3. ncbi request reprint Cholesterol and apolipoprotein B metabolism in Tangier disease
    E J Schaefer
    Lipid Metabolism Laboratory, Department of Medicine, New England Medical Center, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 159:231-6. 2001
    ....
  4. ncbi request reprint Effects of atorvastatin on fasting and postprandial lipoprotein subclasses in coronary heart disease patients versus control subjects
    Ernst J Schaefer
    Atherosclerosis Research Laboratory, Lipid and Heart Disease Prevention Clinic, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 90:689-96. 2002
    ..001) by this treatment. Our data indicate that atorvastatin treatment normalizes levels of all classes of triglyceride-rich lipoproteins and LDL in both the fasting and fed states in patients with CHD compared with control subjects...
  5. ncbi request reprint Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and women in the Framingham Offspring Study
    Ernst J Schaefer
    Lipid Research Laboratory, Division of Endocrinology, Diabetes, Metabolism, and Molecular Medicine, New England Medical Center, Boston, Massachusetts 02111, USA
    Diabetes Care 25:989-94. 2002
    ..We hypothesized that diabetic patients would have higher remnant levels than nondiabetic patients...
  6. ncbi request reprint Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in the Framingham Offspring Study
    J R Galluzzi
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 159:417-24. 2001
    ..Our data are consistent with the T54 IFABP increasing the flux of lipids through the enterocyte leading to an increase in chylomicron secretion...
  7. ncbi request reprint Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study
    J M Ordovas
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Arterioscler Thromb Vasc Biol 20:1323-9. 2000
    ..Moreover, these effects appear to translate into a lower CHD risk among those men with the B2 allele...
  8. ncbi request reprint Remnant-like particle (RLP) cholesterol is an independent cardiovascular disease risk factor in women: results from the Framingham Heart Study
    J R McNamara
    Lipid Research Laboratory, New England Medical Center, 750 Washington Street, Box 216, Boston, MA 02111, USA
    Atherosclerosis 154:229-36. 2001
    ..002) after adjustment with other major risk factors. In conclusion, we have documented that RLP-C is an independent risk factor for CVD in women, and provides significantly more information than do triglycerides...
  9. ncbi request reprint Remnant lipoprotein cholesterol and triglyceride reference ranges from the Framingham Heart Study
    J R McNamara
    Division of Endocrinology, Diabetes, Metabolism, and Molecular Medicine, New England Medical Center, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Chem 44:1224-32. 1998
    ..225 mmol/L (8.7 mg/dL) and 0.346 mmol/L (30.6 mg/dL) for men. These data provide reference ranges for use in the evaluation of RLP-C and RLP-TG as potential indicators of risk for coronary heart disease...
  10. pmc Substitution of vegetable oil for a partially-hydrogenated fat favorably alters cardiovascular disease risk factors in moderately hypercholesterolemic postmenopausal women
    Sonia Vega-Lopez
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
    Atherosclerosis 207:208-12. 2009
    ..Acceptable alternatives must be adjudicated. Our objective was to assess the effect of a recent commercial fat substitution, corn oil for partially-hydrogenated soybean oil...
  11. ncbi request reprint Association of the Ala54-Thr polymorphism in the intestinal fatty acid-binding protein with 2-h postchallenge insulin levels in the Framingham Offspring Study
    J R Galluzzi
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Diabetes Care 24:1161-6. 2001
    ....
  12. ncbi request reprint Apolipoprotein E isoform polymorphisms are not associated with insulin resistance: the Framingham Offspring Study
    J B Meigs
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Diabetes Care 23:669-74. 2000
    ..We examined the relationship between insulin resistance and apo(e) polymorphisms among participants in the Framingham Offspring Study...
  13. ncbi request reprint Alcohol drinking determines the effect of the APOE locus on LDL-cholesterol concentrations in men: the Framingham Offspring Study
    D Corella
    Lipid Metabolism Laboratory and the Epidemiology Program, Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 73:736-45. 2001
    ..No significant associations were observed in men or women with the E3 allele. CONCLUSION: In men, the effects of alcohol intake on LDL cholesterol are modulated in part by variability at the APOE locus...
  14. ncbi request reprint Apolipoprotein E genotype affects plasma lipid response to atorvastatin in a gender specific manner
    J Pedro-Botet
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, New England Medical Center, Boston, MA, USA
    Atherosclerosis 158:183-93. 2001
    ..In summary, atorvastatin treatment had similar effects on plasma lipid levels in both men and women; however, the apoE gene locus was a significant predictor of LDL-C and TG responses to atorvastatin therapy in men, but not in women...
  15. ncbi request reprint Association between the PPARA L162V polymorphism and plasma lipid levels: the Framingham Offspring Study
    E S Tai
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 22:805-10. 2002
    ..This suggests that alterations in triglyceride-rich lipoprotein metabolism may be involved in the generation of the increase in LDL cholesterol observed with the L162V PPARA polymorphism...
  16. ncbi request reprint Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women
    S L Booth
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, USA
    Am J Clin Nutr 71:1201-8. 2000
    ..Vitamin K has been associated with bone mineral density (BMD) and risk of hip fracture. The apolipoprotein (apo) E4 allele (APOE*E4) has been associated with bone fracture through a putative effect on vitamin K transport in blood...
  17. ncbi request reprint Human apolipoprotein (Apo) B-48 and ApoB-100 kinetics with stable isotopes
    F K Welty
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 19:2966-74. 1999
    ....
  18. ncbi request reprint Frequency of ApoB and ApoE gene mutations as causes of hypobetalipoproteinemia in the framingham offspring population
    F K Welty
    Lipid Metabolism Laboratory, Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 18:1745-51. 1998
    ..21). In conclusion, a truncated apoB was a rare cause of HBLP, whereas the E2/E3 genotype was a much more common cause. A large prospective study is needed to evaluate the incidence of cancer and atherosclerosis in subjects with HBLP...
  19. ncbi request reprint Decreased production and increased catabolism of apolipoprotein B-100 in apolipoprotein B-67/B-100 heterozygotes
    F K Welty
    Jean Meyer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 17:881-8. 1997
    ..002) due primarily to a lower production rate (27% of control values). Thus, both decreased production of VLDL and LDL apoB-100 and increased catabolism of VLDL apoB-100 are responsible for the low levels of apoB-100 in apoB-67 subjects...
  20. ncbi request reprint Frequency of phenotype-genotype discrepancies at the apolipoprotein E locus in a large population study
    C Lahoz
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Clin Chem 42:1817-23. 1996
    ..Our results indicate that most discrepancies between genotype and phenotype assessment of apoE polymorphism were due to sample mishandling, data entry, and technical difficulties rather than true discordances...
  21. ncbi request reprint Lipidemic effects of an interesterified mixture of butter, medium-chain triacylglycerol and safflower oils
    E A Mascioli
    Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts, USA
    Lipids 34:889-94. 1999
    ..72 mM; IM, 1.96+/-0.86 mM, P < 0.05). We conclude that an IM of B, MCT, and safflower oils as compared to native B has no appreciable effect on plasma cholesterol concentrations but is associated with a modest rise in plasma TAG...
  22. ncbi request reprint A promoter polymorphism in cholesterol 7alpha-hydroxylase interacts with apolipoprotein E genotype in the LDL-lowering response to atorvastatin
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, USA
    Atherosclerosis 180:407-15. 2005
    ..We concluded that the CYP7A1 A-204C promoter variant was associated with poor response to atorvastatin, which were additively enhanced by common variants in another locus, APOE...
  23. pmc Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Endocrinol (Oxf) 72:169-75. 2010
    ..Subjects Postmenopausal Caucasian women (n = 208) participating in a placebo-controlled randomized trial of 3.2 years of hormone therapy (HT)...
  24. ncbi request reprint Gender-specific effects of estrogen receptor alpha gene haplotype on high-density lipoprotein cholesterol response to atorvastatin: interaction with apolipoprotein AI gene polymorphism
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, MA, USA
    Atherosclerosis 178:331-8. 2005
    ....
  25. ncbi request reprint The L162V polymorphism at the peroxisome proliferator activated receptor alpha locus modulates the risk of cardiovascular events associated with insulin resistance and diabetes mellitus: the Veterans Affairs HDL Intervention Trial (VA-HIT)
    E Shyong Tai
    Nutrition and Genomics Unit, Jean Mayer USDA Human Nutrition Research Center for Aging at Tufts University, Boston, MA, USA
    Atherosclerosis 187:153-60. 2006
    ..We hypothesized that the association between a functional polymorphism at the PPARA locus (L162V) and the risk of a CV event, as well as response to fibrate therapy, might be greatest in those with either IR or DM (DM/IR) in VA-HIT...
  26. ncbi request reprint Subpopulations of high density lipoproteins in homozygous and heterozygous Tangier disease
    B F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, New England Medical Center, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 156:217-25. 2001
    ..These abnormalities appear to result in a higher risk of CHD in heterozygotes than in unaffected controls...
  27. ncbi request reprint Human triglyceride-rich lipoprotein apo E kinetics and its relationship to LDL apo B-100 metabolism
    J S Millar
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Atherosclerosis 155:477-85. 2001
    ....
  28. ncbi request reprint Interrelationships between human apolipoprotein A-I and apolipoproteins B-48 and B-100 kinetics using stable isotopes
    Francine K Welty
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 24:1703-7. 2004
    ..Our purpose was to determine the relationship between apolipoprotein (apo) A-I and apoB-48 and apoB-100 metabolism in moderately hypercholesterolemic humans...
  29. ncbi request reprint ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, MA, USA
    J Lipid Res 45:653-6. 2004
    ..These results suggest that, in patients with hypercholesterolemia, the ABCG8 D19H variant is associated with greater LDLC-lowering response to atorvastatin therapy...
  30. doi request reprint Effects of intensive atorvastatin and rosuvastatin treatment on apolipoprotein B-48 and remnant lipoprotein cholesterol levels
    Seiko Otokozawa
    Cardiovascular Research Laboratory, Friedman School of Nutrition Science and Policy at Tufts University and Tufts University School of Medicine, Boston, MA 02111, USA
    Atherosclerosis 205:197-201. 2009
    ..Our findings utilizing a specific immunoassay and a fairly large number of subjects extend prior studies indicating that statins significantly lower apolipoprotein B containing lipoproteins of both intestinal and liver origin...
  31. ncbi request reprint Human apolipoprotein A-IV metabolism within triglyceride-rich lipoproteins and plasma
    Z Sun
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street 02111, Boston, MA, USA
    Atherosclerosis 156:363-72. 2001
    ....
  32. ncbi request reprint Individual variability in lipoprotein cholesterol response to National Cholesterol Education Program Step 2 diets
    E J Schaefer
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 65:823-30. 1997
    ..Forty-eight percent of the variability in LDL-cholesterol response (in mmol/L) to the diet could be accounted for by baseline LDL concentrations and age in men, and 13% by age in women...
  33. ncbi request reprint Distribution of ApoA-I-containing HDL subpopulations in patients with coronary heart disease
    B F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 20:2670-6. 2000
    ....
  34. ncbi request reprint Impact of hydrogenated fat on high density lipoprotein subfractions and metabolism
    A H Lichtenstein
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Lipid Res 42:597-604. 2001
    ..These data suggest that the saturated fatty acid component, rather than the trans- or polyunsaturated fatty acid component, of the diets was the putative factor in modulating HDL cholesterol response...
  35. ncbi request reprint Effects of different forms of dietary hydrogenated fats on serum lipoprotein cholesterol levels
    A H Lichtenstein
    Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    N Engl J Med 340:1933-40. 1999
    ..We compared the effects of diets with a broad range of trans fatty acids on serum lipoprotein cholesterol levels...
  36. ncbi request reprint Effects of ApoE genotype on ApoB-48 and ApoB-100 kinetics with stable isotopes in humans
    F K Welty
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 20:1807-10. 2000
    ..05). In conclusion, the presence of 1 E4 allele was associated with higher LDL apoB-100 levels owing to lower fractional catabolism of LDL apoB-100 and a 33% increase in the conversion of VLDL apoB-100 to LDL apoB-100...
  37. ncbi request reprint Common variants in the gene encoding ATP-binding cassette transporter 1 in men with low HDL cholesterol levels and coronary heart disease
    M E Brousseau
    The Lipid Metabolism Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts, Boston, MA, USA
    Atherosclerosis 154:607-11. 2001
    ....
  38. ncbi request reprint Genetic variation at the hormone sensitive lipase: gender-specific association with plasma lipid and glucose concentrations
    L Qi
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Genet 65:93-100. 2004
    ..These SNPs were not significantly associated with anthropometrical variables. In summary, variation at this locus showed gender-specific associations with lipids and glucose measures, and the latter was influenced by alcohol drinking...
  39. ncbi request reprint Urbanization elicits a more atherogenic lipoprotein profile in carriers of the apolipoprotein A-IV-2 allele than in A-IV-1 homozygotes
    H Campos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 17:1074-81. 1997
    ..Therefore, under the conditions studied, persons with the apoA-IV-2 allele may be more susceptible to CHD...
  40. ncbi request reprint Insulin resistance and cardiovascular events with low HDL cholesterol: the Veterans Affairs HDL Intervention Trial (VA-HIT)
    Sander J Robins
    Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Diabetes Care 26:1513-7. 2003
    ....
  41. ncbi request reprint Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study
    E Shyong Tai
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
    J Nutr 135:397-403. 2005
    ..Our data show that the effect of the L162V polymorphism on plasma TG and apoC-III concentrations depends on the dietary PUFA, with a high intake triggering lower TG in carriers of the 162V allele...
  42. ncbi request reprint Effects of estrogen and medroxyprogesterone acetate on subpopulations of triglyceride-rich lipoproteins and high-density lipoproteins
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory and the Biostatistics Unit, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Metabolism 52:1330-6. 2003
    ....
  43. ncbi request reprint Genetic determinants of plasma lipid response to dietary intervention: the role of the APOA1/C3/A4 gene cluster and the APOE gene
    J M Ordovas
    Lipid Metabolism Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Br J Nutr 83:S127-36. 2000
    ..e. APOB, CETP, LPL, FABP2, SRBI, ABC1 and CYP7)...
  44. ncbi request reprint Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham offspring study
    G T Russo
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 158:173-81. 2001
    ..Despite the described associations with lipid and glucose metabolism related risk factors, we did not find any significant increase in CHD risk associated with the S2 allele in this population...
  45. ncbi request reprint An oat-containing hypocaloric diet reduces systolic blood pressure and improves lipid profile beyond effects of weight loss in men and women
    E Saltzman
    The Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Nutr 131:1465-70. 2001
    ..41 mmol/L, control -0.2 +/- 0.41mmol/L, P = 0.008). In summary, a hypocaloric diet containing oats consumed over 6 wk resulted in greater improvements in systolic blood pressure and lipid profile than did a hypocaloric diet without oats...
  46. ncbi request reprint CYP3A4 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin in primary hypercholesterolemia
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 93:104-7. 2004
    ....
  47. ncbi request reprint Fasting and postprandial apolipoprotein B-48 levels in healthy, obese, and hyperlipidemic subjects
    Seiko Otokozawa
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 58:1536-42. 2009
    ..Median apo B-48 values in healthy subjects are about 0.5 mg/dL and increase more than 100% in the fed state. Elevated levels are observed in obese and hyperlipidemic subjects...
  48. ncbi request reprint Interactions between common genetic polymorphisms in ABCG5/G8 and CYP7A1 on LDL cholesterol-lowering response to atorvastatin
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, MA, USA
    Atherosclerosis 175:287-93. 2004
    ..The other ABCG5/G8 polymorphisms did not show any significant interactions with the CYP7A1 polymorphism. We conclude that the ABCG8 H19 and CYP7A1 C-204 alleles appear to interact in a dose-dependent manner on atorvastatin response...
  49. ncbi request reprint Gender-specific association of a perilipin gene haplotype with obesity risk in a white population
    Lu Qi
    Nutrition and Genomics Laboratories, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Obes Res 12:1758-65. 2004
    ..Our purpose was to examine the association between common single-nucleotide polymorphisms (SNPs) at the perilipin (PLIN) locus and obesity, as well as related phenotypes, in unrelated American adults...
  50. pmc Effects of cholesteryl ester transfer protein inhibition on apolipoprotein A-II-containing HDL subspecies and apolipoprotein A-II metabolism
    Margaret E Brousseau
    Cardiovascular Research Laboratory, Tufts University School of Medicine, Boston, MA, USA
    J Lipid Res 50:1456-62. 2009
    ..Our findings indicate that CETP inhibition increases plasma concentrations of apoA-II by delaying HDL apoA-II catabolism and significantly alters the remodeling of apoA-II-containing HDL subpopulations...
  51. ncbi request reprint Comparison of the effects of pravastatin and lovastatin on sleep disturbance in hypercholesterolemic subjects
    B L Ehrenberg
    Department of Neurology, New England Medical Center, Boston, Mass. 02111, USA
    Sleep 22:117-21. 1999
    ..Nevertheless, the subjects did have moderate sleep disturbances that could account for insomnia and most likely predate the use of HMG-CoA reductase inhibitors...
  52. ncbi request reprint Effects of apolipoprotein A-I genetic variations on plasma apolipoprotein, serum lipoprotein and glucose levels
    I A Larson
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Tufts University School of Medicine, New England Medical Center, Boston, MA, USA
    Clin Genet 61:176-84. 2002
    ....
  53. ncbi request reprint Assessment of the safety of supplementation with different amounts of vitamin E in healthy older adults
    S N Meydani
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 68:311-8. 1998
    ..Thus, 4 mo of supplementation with 60-800 IU vitamin E/d had no adverse effects. These results are relevant for determining risk-to-benefit ratios for vitamin E supplementation...
  54. ncbi request reprint Impact of body mass index on coronary heart disease risk factors in men and women. The Framingham Offspring Study
    S Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 16:1509-15. 1996
    ..These results emphasize the importance of excess body fat as a public health issue...
  55. ncbi request reprint Risk of cardiovascular disease in a cohort of HIV-infected adults: a study using carotid intima-media thickness and coronary artery calcium score
    Alexandra Mangili
    Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
    Clin Infect Dis 43:1482-9. 2006
    ..We measured 2 surrogate markers of subclinical atherosclerosis, carotid intima-media thickness (c-IMT) and coronary artery calcium (CAC) scores, in HIV-infected adults...
  56. ncbi request reprint Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the framingham study
    Doreen Osgood
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 88:2869-79. 2003
    ..03 for interaction). Similar results were obtained for HDL(2)-C. In conclusion, SR-BI gene variation modulates the lipid profile, particularly in type 2 diabetes, contributing to the metabolic abnormalities in these subjects...
  57. pmc Sex hormone modulation of proinflammatory cytokine and C-reactive protein expression in macrophages from older men and postmenopausal women
    Michael P Corcoran
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Endocrinol 206:217-24. 2010
    ..Our results indicate that testosterone may exert anti-inflammatory effects by reducing macrophage TNF-alpha expression, while the effects of estrogen on macrophage CRP expression may depend upon the extracellular lipid environment...
  58. ncbi request reprint Effects of maximal doses of atorvastatin versus rosuvastatin on small dense low-density lipoprotein cholesterol levels
    Masumi Ai
    Cardiovascular Research Laboratory, Friedman School of Nutrition Science and Policy at Tufts University, Boston, Massachusetts, USA
    Am J Cardiol 101:315-8. 2008
    ....
  59. ncbi request reprint Effect of hydrogenated and saturated, relative to polyunsaturated, fat on immune and inflammatory responses of adults with moderate hypercholesterolemia
    Sung Nim Han
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Lipid Res 43:445-52. 2002
    ....
  60. ncbi request reprint Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study
    C Lahoz
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Atherosclerosis 154:529-37. 2001
    ..The apo E4 (Arg112-Cys) polymorphism has been associated with dementia and hypercholesterolemia. We investigated the relation of APOE genotype to cardiovascular disease (CVD) in the Framingham Offspring Study...
  61. ncbi request reprint Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trial
    S J Robins
    Department of Medicine, Boston University School of Medicine, 88 E Newton St, Boston, MA 02118, USA
    JAMA 285:1585-91. 2001
    ..1 years by treating patients with the fibric acid derivative gemfibrozil when the predominant lipid abnormality was low HDL-C...
  62. ncbi request reprint Diet and coronary heart disease: clinical trials
    M E Brousseau
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Curr Atheroscler Rep 2:487-93. 2000
    ..The purpose of this report is to review dietary intervention trials that support a direct relationship between diet, lipoproteins, and CHD risk...
  63. ncbi request reprint The metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein (a) in human beings
    Jennifer L Jenner
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Metabolism 54:361-9. 2005
    ....
  64. ncbi request reprint Men and women differ in lipoprotein response to dietary saturated fat and cholesterol restriction
    Zhengling Li
    Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:3428-33. 2003
    ..These data are consistent with the concept that middle aged/elderly men may have a more favorable lipoprotein response to a low fat, low cholesterol diet than postmenopausal women...
  65. pmc Altering dietary lysine:arginine ratio has little effect on cardiovascular risk factors and vascular reactivity in moderately hypercholesterolemic adults
    Sonia Vega-Lopez
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Atherosclerosis 210:555-62. 2010
    ..Information is scarce regarding the effect of dietary protein type, with specific focus on the lysine-to-arginine (Lys:Arg) ratio, on cardiovascular risk factors and vascular reactivity in humans...
  66. ncbi request reprint Stable isotope turnover of apolipoproteins of high-density lipoproteins in humans
    J B Marsh
    Jean Mayer US Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Curr Opin Lipidol 11:261-6. 2000
    ..Stable isotope studies have strengthened the evidence that triglyceride enrichment of HDL increases its catabolism Laboratory...
  67. ncbi request reprint Novel mutations in the gene encoding ATP-binding cassette 1 in four tangier disease kindreds
    M E Brousseau
    Lipid Metabolism Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University and Department of Medicine, New England Medical Center, Boston, MA 02111, USA
    J Lipid Res 41:433-41. 2000
    ..These results establish a causal role for mutations in hABC-1 in TD and indicate that this transporter has a critical function in the regulation of intracellular lipid trafficking that dramatically affects plasma HDL cholesterol levels...
  68. ncbi request reprint Genes, variation of cholesterol and fat intake and serum lipids
    J M Ordovas
    Lipid Metabolism Laboratory, JM USDA Human Nutrition Research Centre on Ageing, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 10:15-22. 1999
    ..Other loci, including APOA4, APOA1 and APOB have also been found to account for some of the variability in the fasting and fed states...
  69. ncbi request reprint Influence of photoperiod, laboratory caging and aging on plasma lipid response to an atherogenic diet among F1B hamsters
    D Smith
    Comparative Biology and Medicine, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Int J Neurosci 106:185-94. 2001
    ..005). In conclusion, photoperiod length dramatically affects diet-induced plasma lipid concentrations in young male F1B hamsters, and thus needs be considered in experimental designs of animal-housed lipid research...
  70. ncbi request reprint Multicenter evaluation of a patient-administered test for blood cholesterol measurement
    J R McNamara
    Lipid Metabolism Laboratory, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Prev Med 25:583-92. 1996
    ....
  71. ncbi request reprint Effects of a National Cholesterol Education Program Step II Diet on apolipoprotein A-IV metabolism within triacylglycerol-rich lipoproteins and plasma
    Z Sun
    Lipid Metabolism Laboratory and the Mass Spectrometry Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 74:308-14. 2001
    ....
  72. ncbi request reprint Familial apolipoprotein A-I, C-III, and A-IV deficiency and premature atherosclerosis due to deletion of a gene complex on chromosome 11
    J M Ordovas
    United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111
    J Biol Chem 264:16339-42. 1989
    ..The data support the concept of an independent role for HDL in the pathogenesis of atherosclerosis...
  73. pmc Gender-specific differences in the kinetics of nonfasting TRL, IDL, and LDL apolipoprotein B-100 in men and premenopausal women
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:1838-43. 2008
    ..To investigate mechanisms underlying gender differences in serum lipoprotein concentrations, the kinetic behavior of apoB-100 was assessed...
  74. ncbi request reprint LpA-I, LpA-I:A-II HDL and CHD-risk: The Framingham Offspring Study and the Veterans Affairs HDL Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, JM USDA HNRCA, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 188:59-67. 2006
    ..We tested the hypothesis that concentrations of LpA-I and/or LpA-I:A-II HDL subclasses are significantly associated with CHD prevalence and recurrent cardiovascular events...
  75. pmc Role of the estrogen and progestin in hormonal replacement therapy on apolipoprotein A-I kinetics in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 26:385-91. 2006
    ..Hormonal replacement therapy (HRT) affects plasma HDL cholesterol levels, with estrogen increasing HDL cholesterol levels and progestins blunting this effect. This study was designed to assess the mechanism responsible for these effects...
  76. pmc Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway
    Thomas M van Himbergen
    Lipid Metabolism Laboratory, Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    Arterioscler Thromb Vasc Biol 30:113-20. 2010
    ..In light of prior metabolic and genetic research, our purpose was to ascertain whether FCH cases had significant abnormalities of plasma markers of cholesterol synthesis and absorption as compared to unaffected kindred members...
  77. ncbi request reprint Cholesteryl ester transfer protein inhibition, high-density lipoprotein metabolism and heart disease risk reduction
    Ernst J Schaefer
    Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University, Boston, Massachusetts, USA
    Curr Opin Lipidol 17:394-8. 2006
    ....
  78. ncbi request reprint Potential role of dietary n-3 fatty acids in the prevention of dementia and macular degeneration
    Elizabeth J Johnson
    Carotenoid and Health and Lipid Metabolism Laboratories, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 83:1494S-1498S. 2006
    ..7 fish servings/wk) is associated with an approximately 50% reduction in dementia risk. At least this amount of DHA is generally found in one commercially available 1-g fish oil capsule given daily...
  79. ncbi request reprint Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population
    Eliana Polisecki
    Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Atherosclerosis 200:95-101. 2008
    ..Our data support the concept that the rare allele of the R46L SNP at the PCSK9 locus significantly lowers LDL C, but does not greatly reduce CHD risk in an elderly population with a high prevalence of cardiovascular disease...
  80. ncbi request reprint Should we target HDL-cholesterol to reduce coronary heart disease risk?
    Ernst J Schaefer
    Cardiovascular Research Laboratory, Tufts University School of Medicine, Boston, MA 02111, USA
    Nat Clin Pract Endocrinol Metab 2:358-9. 2006
  81. ncbi request reprint Novel soybean oils with different fatty acid profiles alter cardiovascular disease risk factors in moderately hyperlipidemic subjects
    Alice H Lichtenstein
    Cardiovascular Nutrition Laboratory and the Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 84:497-504. 2006
    ..A variety of soybean oils were developed with improved oxidative stability and functional characteristics for use as alternatives to partially hydrogenated fat...
  82. pmc Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial
    Nirupa R Matthan
    Cardiovascular Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 51:202-9. 2010
    ..The magnitude of these alterations were similar between cases and controls and do not explain differences in outcomes with pravastatin treatment...
  83. pmc Extended-release niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and ApoB-containing lipoproteins
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:1672-8. 2008
    ..Extended-release niacin effectively lowers plasma TG levels and raises plasma high-density lipoprotein (HDL) cholesterol levels, but the mechanisms responsible for these effects are unclear...
  84. pmc Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD
    Nirupa R Matthan
    Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 50:1927-35. 2009
    ..These data suggest that impaired cholesterol homeostasis, reflected by lower synthesis and higher absorption marker concentrations, are highly significant independent predictors of prevalent CVD in this study population...
  85. ncbi request reprint Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study
    Ernst J Schaefer
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tuffs University, Boston, MA 02111, USA
    Arch Neurol 63:1545-50. 2006
    ..Docosahexaenoic acid (DHA) is an abundant fatty acid in the brain. In the diet, DHA is found mostly in fatty fish. The content of DHA has been shown to be decreased in the brain and plasma of patients with dementia...
  86. pmc Dietary fructose and glucose differentially affect lipid and glucose homeostasis
    Ernst J Schaefer
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Cardiovascular Research Laboratory, Friedman School of Nutrition Science and Policy, Tufts University School of Medicine, Boston, MA 02111, USA
    J Nutr 139:1257S-1262S. 2009
    ....
  87. ncbi request reprint Role of LCAT in HDL remodeling: investigation of LCAT deficiency states
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:592-9. 2007
    ....
  88. ncbi request reprint Comparison of the effects of high doses of rosuvastatin versus atorvastatin on the subpopulations of high-density lipoproteins
    Bela F Asztalos
    Cardiovascular Research Laboratory, Tufts University, Boston, Massachusetts, USA
    Am J Cardiol 99:681-5. 2007
    ..In conclusion, our data show that both statins, given at their maximal doses, favorably alter the HDL subpopulation profile, but also that rosuvastatin is significantly more effective in this regard than atorvastatin...
  89. ncbi request reprint Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:1746-53. 2007
    ..Atorvastatin-mediated changes in cholesterol homeostasis may contribute to apoB PR regulation...
  90. pmc Relation of gemfibrozil treatment and high-density lipoprotein subpopulation profile with cardiovascular events in the Veterans Affairs High-Density Lipoprotein Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 57:77-83. 2008
    ..It is quite possible that much of the cardiovascular benefits of gemfibrozil are due to a much wider spectrum of effects on metabolic processes that is not reflected by changes in blood lipids and HDL subpopulations...
  91. ncbi request reprint Value of high-density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, HNRCA, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 25:2185-91. 2005
    ....
  92. ncbi request reprint Polyunsaturated fatty acids modulate the effects of the APOA1 G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the Framingham Study
    Jose M Ordovas
    Nutrition and Genomics Laboratory, the Lipid Metabolism Laboratory and the Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston 02111, USA
    Am J Clin Nutr 75:38-46. 2002
    ..The A allele was shown to be associated with higher HDL-cholesterol concentrations in some studies but not in others...
  93. ncbi request reprint Immunological effects of low-fat diets with and without weight loss
    Michelle S Santos
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Am Coll Nutr 22:174-82. 2003
    ..The immunologic effects of isocaloric reduced- and low-fat diets and a voluntary calorie-restricted low-fat diet resulting in weight loss were compared to the immunologic effects of an average American diet in hyperlipidemic individuals...
  94. ncbi request reprint Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston Mass 02111, USA
    Arterioscler Thromb Vasc Biol 24:1092-7. 2004
    ....
  95. ncbi request reprint Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol
    Margaret E Brousseau
    Lipid Research Laboratory, Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    N Engl J Med 350:1505-15. 2004
    ..Inhibition of cholesteryl ester transfer protein (CETP) has been proposed as a strategy to raise HDL cholesterol levels...
  96. ncbi request reprint New targets for medical treatment of lipid disorders
    Margaret E Brousseau
    JM USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Curr Atheroscler Rep 4:343-9. 2002
    ....
  97. ncbi request reprint Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects
    Alice H Lichtenstein
    Cardiovascular Nutrition Laboratory and Lipid Metabolism Laboratory, JM HNRC Human Nutrition Research Center on Aging at Tufts University, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 22:1852-8. 2002
    ..The objective of this study was to assess the independent effect of soy relative to common sources of animal protein and soy-derived isoflavones on blood lipids...
  98. ncbi request reprint Comparisons of effects of statins (atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin) on fasting and postprandial lipoproteins in patients with coronary heart disease versus control subjects
    Ernst J Schaefer
    Atherosclerosis Research Laboratory, Lipid and Heart Disease Prevention Clinic, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Cardiol 93:31-9. 2004
    ....
  99. ncbi request reprint Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 45:448-55. 2004
    ....
  100. ncbi request reprint High-density lipoprotein subpopulation profile and coronary heart disease prevalence in male participants of the Framingham Offspring Study
    Bela F Asztalos
    Lipid Metabolism Laboratory, HNRCA at Tufts University, 711 Washington Street, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 24:2181-7. 2004
    ..We tested the hypothesis whether specific HDL subpopulations are significantly associated with CHD-prevalence...
  101. ncbi request reprint Association of apo A-IV 360 (Gln --> His) polymorphism with plasma lipids and lipoproteins: the Framingham Offspring Study
    Maysa S Cendoroglo
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 179:169-75. 2005
    ..In conclusion, the apo A-IV-2 allele is associated with a modest reduction in plasma triglyceride levels in the general population...