BEVERLY RUBIN

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. doi request reprint Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects
    Beverly S Rubin
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States
    J Steroid Biochem Mol Biol 127:27-34. 2011
  2. pmc Bisphenol A: Perinatal exposure and body weight
    Beverly S Rubin
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States
    Mol Cell Endocrinol 304:55-62. 2009
  3. ncbi request reprint Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of bisphenol A
    Beverly S Rubin
    Tufts University, School of Medicine, Boston, Massachusetts 02111, USA
    Endocrinology 147:3681-91. 2006
  4. pmc Perinatal exposure to bisphenol-A alters peripubertal mammary gland development in mice
    Mónica Muñoz-de-Toro
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Endocrinology 146:4138-47. 2005
  5. doi request reprint Interpreting endocrine disruption from an integrative biology perspective
    Ana M Soto
    Tufts University School of Medicine, Boston, MA 02111, USA
    Mol Cell Endocrinol 304:3-7. 2009
  6. pmc Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, Massachusetts 02111, USA
    Endocrinology 148:116-27. 2007
  7. ncbi request reprint Long-term effects of fetal exposure to low doses of the xenoestrogen bisphenol-A in the female mouse genital tract
    Caroline M Markey
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111 1800, USA
    Biol Reprod 72:1344-51. 2005
  8. pmc Perinatal bisphenol A exposure increases estrogen sensitivity of the mammary gland in diverse mouse strains
    Perinaaz R Wadia
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Environ Health Perspect 115:592-8. 2007
  9. pmc Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Endocr Rev 30:75-95. 2009
  10. ncbi request reprint Endocrine disruptors and reproductive health: the case of bisphenol-A
    Maricel V Maffini
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, MA 02111, United States
    Mol Cell Endocrinol 254:179-86. 2006

Collaborators

Detail Information

Publications18

  1. doi request reprint Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects
    Beverly S Rubin
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States
    J Steroid Biochem Mol Biol 127:27-34. 2011
    ..Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging...
  2. pmc Bisphenol A: Perinatal exposure and body weight
    Beverly S Rubin
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States
    Mol Cell Endocrinol 304:55-62. 2009
    ..The mechanisms through which perinatal BPA exposure acts to exert persistent effects on body weight and adiposity remain to be determined. Possible targets of BPA action are discussed...
  3. ncbi request reprint Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of bisphenol A
    Beverly S Rubin
    Tufts University, School of Medicine, Boston, Massachusetts 02111, USA
    Endocrinology 147:3681-91. 2006
    ..These data indicate that BPA may be capable of altering important events during critical periods of brain development...
  4. pmc Perinatal exposure to bisphenol-A alters peripubertal mammary gland development in mice
    Mónica Muñoz-de-Toro
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Endocrinology 146:4138-47. 2005
    ....
  5. doi request reprint Interpreting endocrine disruption from an integrative biology perspective
    Ana M Soto
    Tufts University School of Medicine, Boston, MA 02111, USA
    Mol Cell Endocrinol 304:3-7. 2009
    ..It will promote the identification of similar and unique effects of different endocrine disruptors, and their inter-relationships...
  6. pmc Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, Massachusetts 02111, USA
    Endocrinology 148:116-27. 2007
    ..These results suggest that alterations in mammary gland phenotypes observed at puberty and adulthood in perinatally exposed mice have their origins in fetal development...
  7. ncbi request reprint Long-term effects of fetal exposure to low doses of the xenoestrogen bisphenol-A in the female mouse genital tract
    Caroline M Markey
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111 1800, USA
    Biol Reprod 72:1344-51. 2005
    ..In addition, BPA-induced alterations that specifically affect hypothalamic-pituitary-gonadal axis function may further contribute to the anomalies observed at 3 mo of age, long after the cessation of BPA exposure...
  8. pmc Perinatal bisphenol A exposure increases estrogen sensitivity of the mammary gland in diverse mouse strains
    Perinaaz R Wadia
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Environ Health Perspect 115:592-8. 2007
    ..Future studies to assess the role of estrogen receptors as mediators of BPA action require estrogen receptor knock-out mice that were generated on a C57Bl6 background. The sensitivity of the C57Bl6 strain to estradiol and BPA is unknown...
  9. pmc Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Endocr Rev 30:75-95. 2009
    ....
  10. ncbi request reprint Endocrine disruptors and reproductive health: the case of bisphenol-A
    Maricel V Maffini
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, MA 02111, United States
    Mol Cell Endocrinol 254:179-86. 2006
    ....
  11. ncbi request reprint The mammary gland response to estradiol: monotonic at the cellular level, non-monotonic at the tissue-level of organization?
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, MA 02111, USA
    J Steroid Biochem Mol Biol 101:263-74. 2006
    ..This non-monotonic dose-response in the mammary gland may reflect complex interactions, where estrogen can act on multiple targets either as an agonist or antagonist...
  12. ncbi request reprint Endocrine disruptors: from Wingspread to environmental developmental biology
    Caroline M Markey
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111 1800, USA
    J Steroid Biochem Mol Biol 83:235-44. 2002
    ....
  13. ncbi request reprint Estrogen induces CCN5 expression in the rat uterus in vivo
    Holly R Mason
    Program in Cell, Molecular, and Developmental Biology, Sackler School of Biomedical Sciences, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA
    Endocrinology 145:976-82. 2004
    ..Thus, our data indicate that CCN5 is positively regulated by estrogen in the rat uterus and suggests that this gene may play an important role in maintaining normal uterine physiology...
  14. doi request reprint Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 mice
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Ave, Boston, MA 02111, United States
    Reprod Toxicol 26:210-9. 2008
    ..Similar structures have also been observed following exposure to other estrogens. These results are further evidence that perinatal BPA exposure can alter the morphology of the rodent mammary gland in adulthood...
  15. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007
  16. pmc In vivo effects of bisphenol A in laboratory rodent studies
    Catherine A Richter
    U S Geological Survey, Columbia Environmental Research Center, Columbia, MO 65201, United States
    Reprod Toxicol 24:199-224. 2007
    ..We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system...
  17. ncbi request reprint In situ characterization of gonadotropin- releasing hormone-I, -III, and glutamic acid decarboxylase expression in the brain of the sea lamprey, Petromyzon marinus
    Adam R Root
    Department of Biochemistry and Molecular Biology, University of New Hampshire, Durham, NH 03824, USA
    Brain Behav Evol 65:60-70. 2005
    ..These data suggest that gamma-aminobutyric acid (GABA) may directly affect GnRH release in the brain of the sea lamprey...
  18. ncbi request reprint The spatial relationship of gamma-aminobutyric acid (GABA) neurons and gonadotropin-releasing hormone (GnRH) neurons in larval and adult sea lamprey, Petromyzon marinus
    Karen L Reed
    Department of Biochemistry and Molecular Biology, University of New Hampshire, Durham 03824, USA
    Brain Behav Evol 60:1-12. 2002
    ..This close spatial relationship of GABA neurons and GnRH neurons provides a basis for a regulatory role of GABA on GnRH neurons in the sea lamprey...

Research Grants5

  1. AGE-RELATED LOSS OF CYCLICITY--LHRH NEURONAL DYSFUNCTION
    BEVERLY RUBIN; Fiscal Year: 2002
    ..The studies proposed will determine if modulation of excitatory and inhibitory neurotransmission can enhance the normally diminished levels of LHRH neuronal activity in middle-aged females. ..
  2. Does perinatal exposure to Bisphenol A contribute to adult obesity
    BEVERLY RUBIN; Fiscal Year: 2007
    ..It is expected that these results, in turn, may generate a better understanding of the obesity problem, and provide elements to help devise a sound policy addressing this serious public health problem. ..