Research Topics
| BEVERLY RUBINSummaryAffiliation: Tufts University Country: USA Publications
Research Grants
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Detail Information
Publications
Bisphenol A: an endocrine disruptor with widespread exposure and multiple effectsBeverly S Rubin
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States
J Steroid Biochem Mol Biol 127:27-34. 2011..Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging...
Bisphenol A: Perinatal exposure and body weightBeverly S Rubin
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States
Mol Cell Endocrinol 304:55-62. 2009..The mechanisms through which perinatal BPA exposure acts to exert persistent effects on body weight and adiposity remain to be determined. Possible targets of BPA action are discussed...
Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of bisphenol ABeverly S Rubin
Tufts University, School of Medicine, Boston, Massachusetts 02111, USA
Endocrinology 147:3681-91. 2006..These data indicate that BPA may be capable of altering important events during critical periods of brain development...- Perinatal exposure to bisphenol-A alters peripubertal mammary gland development in miceMónica Muñoz-de-Toro
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
Endocrinology 146:4138-47. 2005.... - Interpreting endocrine disruption from an integrative biology perspectiveAna M Soto
Tufts University School of Medicine, Boston, MA 02111, USA
Mol Cell Endocrinol 304:3-7. 2009..It will promote the identification of similar and unique effects of different endocrine disruptors, and their inter-relationships... - Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary glandLaura N Vandenberg
Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, Massachusetts 02111, USA
Endocrinology 148:116-27. 2007..These results suggest that alterations in mammary gland phenotypes observed at puberty and adulthood in perinatally exposed mice have their origins in fetal development... - Long-term effects of fetal exposure to low doses of the xenoestrogen bisphenol-A in the female mouse genital tractCaroline M Markey
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111-1800, USA
Biol Reprod 72:1344-51. 2005..In addition, BPA-induced alterations that specifically affect hypothalamic-pituitary-gonadal axis function may further contribute to the anomalies observed at 3 mo of age, long after the cessation of BPA exposure... - Perinatal bisphenol A exposure increases estrogen sensitivity of the mammary gland in diverse mouse strainsPerinaaz R Wadia
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Environ Health Perspect 115:592-8. 2007..Future studies to assess the role of estrogen receptors as mediators of BPA action require estrogen receptor knock-out mice that were generated on a C57Bl6 background. The sensitivity of the C57Bl6 strain to estradiol and BPA is unknown... - Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruptionLaura N Vandenberg
Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
Endocr Rev 30:75-95. 2009.... - Endocrine disruptors and reproductive health: the case of bisphenol-AMaricel V Maffini
Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, MA 02111, United States
Mol Cell Endocrinol 254:179-86. 2006.... - The mammary gland response to estradiol: monotonic at the cellular level, non-monotonic at the tissue-level of organization?Laura N Vandenberg
Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, MA 02111, USA
J Steroid Biochem Mol Biol 101:263-74. 2006..This non-monotonic dose-response in the mammary gland may reflect complex interactions, where estrogen can act on multiple targets either as an agonist or antagonist... - Endocrine disruptors: from Wingspread to environmental developmental biologyCaroline M Markey
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111-1800, USA
J Steroid Biochem Mol Biol 83:235-44. 2002.... - Estrogen induces CCN5 expression in the rat uterus in vivoHolly R Mason
Program in Cell, Molecular, and Developmental Biology, Sackler School of Biomedical Sciences, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA
Endocrinology 145:976-82. 2004..Thus, our data indicate that CCN5 is positively regulated by estrogen in the rat uterus and suggests that this gene may play an important role in maintaining normal uterine physiology... - Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 miceLaura N Vandenberg
Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Ave, Boston, MA 02111, United States
Reprod Toxicol 26:210-9. 2008..Similar structures have also been observed following exposure to other estrogens. These results are further evidence that perinatal BPA exposure can alter the morphology of the rodent mammary gland in adulthood... - Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposureFrederick S vom Saal
Reprod Toxicol 24:131-8. 2007 - In vivo effects of bisphenol A in laboratory rodent studiesCatherine A Richter
U S Geological Survey, Columbia Environmental Research Center, Columbia, MO 65201, United States
Reprod Toxicol 24:199-224. 2007..We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system... - In situ characterization of gonadotropin- releasing hormone-I, -III, and glutamic acid decarboxylase expression in the brain of the sea lamprey, Petromyzon marinusAdam R Root
Department of Biochemistry and Molecular Biology, University of New Hampshire, Durham, NH 03824, USA
Brain Behav Evol 65:60-70. 2005..These data suggest that gamma-aminobutyric acid (GABA) may directly affect GnRH release in the brain of the sea lamprey... - The spatial relationship of gamma-aminobutyric acid (GABA) neurons and gonadotropin-releasing hormone (GnRH) neurons in larval and adult sea lamprey, Petromyzon marinusKaren L Reed
Department of Biochemistry and Molecular Biology, University of New Hampshire, Durham 03824, USA
Brain Behav Evol 60:1-12. 2002..This close spatial relationship of GABA neurons and GnRH neurons provides a basis for a regulatory role of GABA on GnRH neurons in the sea lamprey...
Research Grants
- AGE-RELATED LOSS OF CYCLICITY--LHRH NEURONAL DYSFUNCTIONBEVERLY RUBIN; Fiscal Year: 2002..The studies proposed will determine if modulation of excitatory and inhibitory neurotransmission can enhance the normally diminished levels of LHRH neuronal activity in middle-aged females. ..
- Does perinatal exposure to Bisphenol A contribute to adult obesityBEVERLY RUBIN; Fiscal Year: 2007..It is expected that these results, in turn, may generate a better understanding of the obesity problem, and provide elements to help devise a sound policy addressing this serious public health problem. ..