A L Roy

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. pmc Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors
    Manching Ku
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    Mol Cell Biol 25:7144-57. 2005
  2. pmc Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells
    Trent Fowler
    Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 9:e87003. 2014
  3. pmc Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies
    Arpita Chatterjee
    Manovikas Biomedical Research and Diagnostic Centre, MRIH, Kolkata, India
    BMC Med Genet 14:12. 2013
  4. pmc Enhancer-promoter communication and transcriptional regulation of Igh
    Ananda L Roy
    Program in Immunology, Department of Pathology, Tufts University School of Medicine, Boston, MA, USA
    Trends Immunol 32:532-9. 2011
  5. ncbi request reprint Transcription factor TFII-I conducts a cytoplasmic orchestra
    Ananda L Roy
    Department of Pathology, Programs in Genetics and Immunology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, Massachusetts 02111, USA
    ACS Chem Biol 1:619-22. 2006
  6. pmc Signal-induced functions of the transcription factor TFII-I
    Ananda L Roy
    Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
    Biochim Biophys Acta 1769:613-21. 2007
  7. ncbi request reprint Biochemistry and biology of the inducible multifunctional transcription factor TFII-I
    A L Roy
    Department of Pathology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Gene 274:1-13. 2001
  8. pmc TFII-I regulates Vbeta promoter activity through an initiator element
    V Cheriyath
    Department of Pathology and Program in Immunology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 18:4444-54. 1998
  9. ncbi request reprint Structure-function analysis of TFII-I. Roles of the N-terminal end, basic region, and I-repeats
    V Cheriyath
    Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 276:8377-83. 2001
  10. pmc Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase
    C D Novina
    Department of Pathology and Program in Immunology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 19:5014-24. 1999

Collaborators

  • Hong bin Ji
  • Ali Shilatifard
  • Ranjan Sen
  • S Kumar
  • Robert G Roeder
  • K Zhang
  • C D Novina
  • Philip Hinds
  • Catarina Sacristán
  • JEFFREY E SETTLEMAN
  • Dashzeveg Bayarsaihan
  • Maria Isabel Tussie-Luna
  • Todd Ashworth
  • Maria B Lazebnik
  • Zana P Desgranges
  • Shweta Hakre
  • V Cheriyath
  • M I Tussié-Luna
  • Trent Fowler
  • Arpita Chatterjee
  • Isabel Tapia-Paez
  • Jaya Rajaiya
  • Phillip A Sharp
  • Wei Jiang
  • Manching Ku
  • Min Hong
  • Dean Tantin
  • Yu Der Wen
  • Edward Seto
  • Ronald Conaway
  • Venugopalan Cheriyath
  • Cheng Ming Chiang
  • Joan Conaway
  • David H Price
  • James E Bradner
  • Payel Ghatak
  • Keya Chaudhuri
  • Samikshan Dutta
  • Sanjit Mukherjee
  • Kanchan Mukhopadhyay
  • Ashis Mukherjee
  • Nupur Mukherjee
  • Avirup Dutta
  • Chinmay Kumar Panda
  • Swagata Sinha
  • Juha Kere
  • Satu Massinen
  • Kristiina Tammimies
  • L Rozo
  • Carol F Webb
  • D W Kim
  • Jamee C Nixon
  • Neil Ayers
  • Jack Wu
  • Carol Prives
  • Peter Baumeister
  • Akiko Hata
  • Sergei Y Sokol
  • Caleb Lee
  • Guang Chao Chen
  • Jen ming Huang
  • Richard C Pestell
  • Amy S Lee
  • Naomi Rosenberg
  • Raffaella Sordella
  • Meng Yin Lin
  • Jinwoo Ahn
  • W Douglas Cress
  • Zana Patrick Desgranges
  • Frank H Ruddle
  • Bertha Michel
  • F H Ruddle
  • B H Cochran

Detail Information

Publications34

  1. pmc Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors
    Manching Ku
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    Mol Cell Biol 25:7144-57. 2005
    ..These results suggest a model in which TFII-I family proteins have opposing effects in the regulation of the Gsc gene in response to a TGFbeta/activin signal...
  2. pmc Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells
    Trent Fowler
    Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 9:e87003. 2014
    ....
  3. pmc Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies
    Arpita Chatterjee
    Manovikas Biomedical Research and Diagnostic Centre, MRIH, Kolkata, India
    BMC Med Genet 14:12. 2013
    ..Here we studied functional genetic polymorphisms (fSNP) in ETS2 and SIM2 encoding genes in a group of patients and control subjects to better understand association of these variants with DS phenotypes...
  4. pmc Enhancer-promoter communication and transcriptional regulation of Igh
    Ananda L Roy
    Program in Immunology, Department of Pathology, Tufts University School of Medicine, Boston, MA, USA
    Trends Immunol 32:532-9. 2011
    ..Here, we review known interactions at the Igh variable region (V(H)) promoters and present our perspective on promoter-enhancer interactions that are likely important for Ig gene regulation in B cells...
  5. ncbi request reprint Transcription factor TFII-I conducts a cytoplasmic orchestra
    Ananda L Roy
    Department of Pathology, Programs in Genetics and Immunology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, Massachusetts 02111, USA
    ACS Chem Biol 1:619-22. 2006
    ..These results establish a novel cytoplasmic function for TFII-I...
  6. pmc Signal-induced functions of the transcription factor TFII-I
    Ananda L Roy
    Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
    Biochim Biophys Acta 1769:613-21. 2007
    ..Here we discuss how a multitude of signaling inputs target TFII-I isoforms, which may exert their functions in distinct phases of the cell cycle and play a key role in the coordinated regulation of cellular proliferation...
  7. ncbi request reprint Biochemistry and biology of the inducible multifunctional transcription factor TFII-I
    A L Roy
    Department of Pathology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Gene 274:1-13. 2001
    ..Here I review the biochemical and biological properties of TFII-I and related proteins in nuclear gene transcription, signal transduction and genetic disorders...
  8. pmc TFII-I regulates Vbeta promoter activity through an initiator element
    V Cheriyath
    Department of Pathology and Program in Immunology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 18:4444-54. 1998
    ....
  9. ncbi request reprint Structure-function analysis of TFII-I. Roles of the N-terminal end, basic region, and I-repeats
    V Cheriyath
    Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 276:8377-83. 2001
    ..These data suggest a model in which TFII-I undergoes regulated homomeric interaction mediated by both the N-terminal end and the I-repeats...
  10. pmc Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase
    C D Novina
    Department of Pathology and Program in Immunology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 19:5014-24. 1999
    ..Thus, mutations impairing the physical and/or functional association between TFII-I and Btk may result in diminished TFII-I-dependent transcription and contribute to defective B-cell development and/or function...
  11. ncbi request reprint Alternatively spliced isoforms of TFII-I. Complex formation, nuclear translocation, and differential gene regulation
    V Cheriyath
    Department of Pathology and Program in Immunology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 275:26300-8. 2000
    ..Thus, TFII-I might differentially regulate its target genes via complex or subcomplex formation...
  12. pmc Repression of TFII-I-dependent transcription by nuclear exclusion
    M I Tussié-Luna
    Department of Pathology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 98:7789-94. 2001
    ..These data suggest a means of transcriptional repression by competition at the level of nuclear occupancy...
  13. ncbi request reprint Regulation of TFII-I activity by phosphorylation
    C D Novina
    Department of Pathology and the Program in Immunology, Sackler School of Graduate Studies, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 273:33443-8. 1998
    ..Taken together, these data suggest that tyrosine phosphorylation of TFII-I is important for its initiator-dependent transcriptional activity...
  14. ncbi request reprint Pro-proliferative function of the long isoform of PML-RARalpha involved in acute promyelocytic leukemia
    M I Tussié-Luna
    Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
    Oncogene 25:3375-86. 2006
    ..Our results suggest that in addition to antagonizing the PML-tumor suppressor or the PML-pro-apoptotic activity, PML-RARalpha proteins can also directly promote cell growth by activating c-fos...
  15. pmc TFII-I enhances activation of the c-fos promoter through interactions with upstream elements
    D W Kim
    Department of Cellular and Molecular Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 18:3310-20. 1998
    ..These results indicate that TFII-I is involved in signal transduction as well as transcriptional activation of the c-fos promoter...
  16. ncbi request reprint Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression
    Shweta Hakre
    Program in Immunology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, Massachusetts 02111, USA
    Mol Cell 24:301-8. 2006
    ..Our results identify a unique growth factor signaling pathway controlled by opposing activities of two TFII-I spliced isoforms...
  17. ncbi request reprint Mechanism of Bruton's tyrosine kinase-mediated recruitment and regulation of TFII-I
    Catarina Sacristán
    Department of Pathology, Program in Immunology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 279:7147-58. 2004
    ..Our results provide a beginning step toward understanding the functional importance of the TFII-I-Btk pathway in B cell signaling and gene expression...
  18. ncbi request reprint T cell-specific expression of the murine CD3delta promoter
    Hong bin Ji
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:47898-906. 2002
    ....
  19. ncbi request reprint Core promoters and transcriptional control
    C D Novina
    Department of Pathology, Sackler School of Biomedical Science, Tufts University School of Medicine, Boston, MA 02111, USA
    Trends Genet 12:351-5. 1996
    ..Thus, the transcriptional regulation of gene expression, both in time and in space, may result from appropriate interfacing of independent signals generated at the core promoter and at the enhancer...
  20. pmc Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta
    Maria Isabel Tussie-Luna
    Department of Pathology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 99:12807-12. 2002
    ..These results suggest a complex interplay between two posttranslational pathways-histone modification and SUMOylation-brokered in part by TFII-I family proteins...
  21. pmc Determination and functional analysis of the consensus binding site for TFII-I family member BEN, implicated in Williams-Beuren syndrome
    Maria B Lazebnik
    Programs in Genetics, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 283:11078-82. 2008
    ....
  22. ncbi request reprint TFII-I: connecting mitogenic signals to cell cycle regulation
    Zana P Desgranges
    Program in Immunology, Tufts University School of Medicine, Boston Massachusetts 02111, USA
    Cell Cycle 5:356-9. 2006
    ..We also discuss a potential role for TFII-I in DNA repair and how it might be involved in signal dependent DNA repair versus cell cycle...
  23. ncbi request reprint c-Src-dependent transcriptional activation of TFII-I
    Venugopalan Cheriyath
    Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 277:22798-805. 2002
    ..These data demonstrate that TFII-I, through a Src-dependent mechanism, reversibly translocates from the cytoplasm to the nucleus, leading to the transcriptional activation of growth-regulated genes...
  24. ncbi request reprint The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I
    Maria Isabel Tussie-Luna
    Department of Pathology, Programs in Immunology and Genetics, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 277:43185-93. 2002
    ..Finally, ectopically expressed Miz1/mPIASxbeta augments the transcriptional activity of TFII-I and relieves the repression exerted by a mutant hMusTRD1/BEN that co-localized with TFII-I in the nucleus...
  25. pmc Inhibition of TFII-I-dependent cell cycle regulation by p53
    Zana P Desgranges
    Program in Immunology, Sackler School of Graduate Biomedical Sciences, Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
    Mol Cell Biol 25:10940-52. 2005
    ....
  26. ncbi request reprint Phase specific functions of the transcription factor TFII-I during cell cycle
    Todd Ashworth
    Program in Immunology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Cell Cycle 8:596-605. 2009
    ..Taken together, TFII-I appears to have distinct roles in distinct phases of the mammalian cell cycle...
  27. pmc Williams-Beuren syndrome-associated transcription factor TFII-I regulates osteogenic marker genes
    Maria B Lazebnik
    Program in Genetics, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 284:36234-9. 2009
    ..Identification of pathways regulated by TFII-I family transcription factors may begin to shed light on the molecular determinants of WBS...
  28. ncbi request reprint Cutting Edge: TFII-I controls B cell proliferation via regulating NF-kappaB
    Todd Ashworth
    Program in Immmunology, Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
    J Immunol 178:2631-5. 2007
    ..Thus, besides controlling c-myc transcription, TFII-I controls B cell proliferation by regulating both nuclear translocation of c-rel and DNA-binding activity of p50 NF-kappaB...
  29. ncbi request reprint An FF domain-dependent protein interaction mediates a signaling pathway for growth factor-induced gene expression
    Wei Jiang
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell 17:23-35. 2005
    ..These findings reveal a pathway by which mitogens promote gene transcription and indicate a role for FF domains in phosphorylation-mediated signal transduction...
  30. ncbi request reprint Regulation of immunoglobulin promoter activity by TFII-I class transcription factors
    Dean Tantin
    Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    J Biol Chem 279:5460-9. 2004
    ..Dominant-negative and RNAi-mediated knockdown experiments indicate that BEN can both positively and negatively regulate IgH promoter activity, depending on the cell line...
  31. pmc Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I
    Jaya Rajaiya
    Oklahoma Medical Research Foundation, Immunobiology and Cancer Research Program, 825 N E 13th Street, Oklahoma City, OK 73104, USA
    Mol Cell Biol 26:4758-68. 2006
    ..These data suggest that Bright functions as a three-component protein complex in the immunoglobulin locus and tie together previous data indicating important roles for Btk and TFII-I in B lymphocytes...
  32. ncbi request reprint Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: role of TFII-I and its tyrosine phosphorylation
    Min Hong
    Department of Biochemistry and Molecular Biology and the University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9176, USA
    J Biol Chem 280:16821-8. 2005
    ..Our studies provide a molecular link that connects the c-Src tyrosine kinase transduction pathway to ER stress-induced transcriptional activation of Grp78 mediated by TFII-I...
  33. pmc The complex of TFII-I, PARP1, and SFPQ proteins regulates the DYX1C1 gene implicated in neuronal migration and dyslexia
    Isabel Tapia-Paez
    Department of Biosciences and Nutrition, 141 57 Huddinge, Karolinska Institute, Stockholm, Sweden
    FASEB J 22:3001-9. 2008
    ..Furthermore, allelic differences in the promoter or 5' untranslated region of DYX1C1 may affect factor binding and thus regulation of the gene...
  34. ncbi request reprint Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I
    Yu Der Wen
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    J Biol Chem 278:1841-7. 2003
    ..These results suggest that HDAC3 modulates some of the functions of TFII-I and provides a link between histone deacetylase and a multifunctional transcriptional activator...