Research Topics
Genomes and Genes | A L RoySummaryAffiliation: Tufts University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factorsManching Ku
Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
Mol Cell Biol 25:7144-57. 2005..These results suggest a model in which TFII-I family proteins have opposing effects in the regulation of the Gsc gene in response to a TGFbeta/activin signal...- Enhancer-promoter communication and transcriptional regulation of IghAnanda L Roy
Program in Immunology, Department of Pathology, Tufts University School of Medicine, Boston, MA, USA
Trends Immunol 32:532-9. 2011..Here, we review known interactions at the Igh variable region (V(H)) promoters and present our perspective on promoter-enhancer interactions that are likely important for Ig gene regulation in B cells... 
Transcription factor TFII-I conducts a cytoplasmic orchestraAnanda L Roy
Department of Pathology, Programs in Genetics and Immunology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, Massachusetts 02111, USA
ACS Chem Biol 1:619-22. 2006..These results establish a novel cytoplasmic function for TFII-I...- Signal-induced functions of the transcription factor TFII-IAnanda L Roy
Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
Biochim Biophys Acta 1769:613-21. 2007..Here we discuss how a multitude of signaling inputs target TFII-I isoforms, which may exert their functions in distinct phases of the cell cycle and play a key role in the coordinated regulation of cellular proliferation... - Biochemistry and biology of the inducible multifunctional transcription factor TFII-IA L Roy
Department of Pathology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Gene 274:1-13. 2001..Here I review the biochemical and biological properties of TFII-I and related proteins in nuclear gene transcription, signal transduction and genetic disorders... - TFII-I regulates Vbeta promoter activity through an initiator elementV Cheriyath
Department of Pathology and Program in Immunology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Mol Cell Biol 18:4444-54. 1998.... - Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinaseC D Novina
Department of Pathology and Program in Immunology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Mol Cell Biol 19:5014-24. 1999..Thus, mutations impairing the physical and/or functional association between TFII-I and Btk may result in diminished TFII-I-dependent transcription and contribute to defective B-cell development and/or function... - Structure-function analysis of TFII-I. Roles of the N-terminal end, basic region, and I-repeatsV Cheriyath
Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 276:8377-83. 2001..These data suggest a model in which TFII-I undergoes regulated homomeric interaction mediated by both the N-terminal end and the I-repeats... - Alternatively spliced isoforms of TFII-I. Complex formation, nuclear translocation, and differential gene regulationV Cheriyath
Department of Pathology and Program in Immunology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 275:26300-8. 2000..Thus, TFII-I might differentially regulate its target genes via complex or subcomplex formation... - Repression of TFII-I-dependent transcription by nuclear exclusionM I Tussié-Luna
Department of Pathology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 98:7789-94. 2001..These data suggest a means of transcriptional repression by competition at the level of nuclear occupancy... - Regulation of TFII-I activity by phosphorylationC D Novina
Department of Pathology and the Program in Immunology, Sackler School of Graduate Studies, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 273:33443-8. 1998..Taken together, these data suggest that tyrosine phosphorylation of TFII-I is important for its initiator-dependent transcriptional activity... - Pro-proliferative function of the long isoform of PML-RARalpha involved in acute promyelocytic leukemiaM I Tussié-Luna
Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
Oncogene 25:3375-86. 2006..Our results suggest that in addition to antagonizing the PML-tumor suppressor or the PML-pro-apoptotic activity, PML-RARalpha proteins can also directly promote cell growth by activating c-fos... - TFII-I enhances activation of the c-fos promoter through interactions with upstream elementsD W Kim
Department of Cellular and Molecular Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Mol Cell Biol 18:3310-20. 1998..These results indicate that TFII-I is involved in signal transduction as well as transcriptional activation of the c-fos promoter... - Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expressionShweta Hakre
Program in Immunology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, Massachusetts 02111, USA
Mol Cell 24:301-8. 2006..Our results identify a unique growth factor signaling pathway controlled by opposing activities of two TFII-I spliced isoforms... - T cell-specific expression of the murine CD3delta promoterHong bin Ji
Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 277:47898-906. 2002.... - Mechanism of Bruton's tyrosine kinase-mediated recruitment and regulation of TFII-ICatarina Sacristán
Department of Pathology, Program in Immunology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 279:7147-58. 2004..Our results provide a beginning step toward understanding the functional importance of the TFII-I-Btk pathway in B cell signaling and gene expression... - Core promoters and transcriptional controlC D Novina
Department of Pathology, Sackler School of Biomedical Science, Tufts University School of Medicine, Boston, MA 02111, USA
Trends Genet 12:351-5. 1996..Thus, the transcriptional regulation of gene expression, both in time and in space, may result from appropriate interfacing of independent signals generated at the core promoter and at the enhancer... - Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbetaMaria Isabel Tussie-Luna
Department of Pathology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 99:12807-12. 2002..These results suggest a complex interplay between two posttranslational pathways-histone modification and SUMOylation-brokered in part by TFII-I family proteins... - The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-IMaria Isabel Tussie-Luna
Department of Pathology, Programs in Immunology and Genetics, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 277:43185-93. 2002..Finally, ectopically expressed Miz1/mPIASxbeta augments the transcriptional activity of TFII-I and relieves the repression exerted by a mutant hMusTRD1/BEN that co-localized with TFII-I in the nucleus... - Inhibition of TFII-I-dependent cell cycle regulation by p53Zana P Desgranges
Program in Immunology, Sackler School of Graduate Biomedical Sciences, Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
Mol Cell Biol 25:10940-52. 2005.... - Phase specific functions of the transcription factor TFII-I during cell cycleTodd Ashworth
Program in Immunology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Cell Cycle 8:596-605. 2009..Taken together, TFII-I appears to have distinct roles in distinct phases of the mammalian cell cycle... - TFII-I: connecting mitogenic signals to cell cycle regulationZana P Desgranges
Program in Immunology, Tufts University School of Medicine, Boston Massachusetts 02111, USA
Cell Cycle 5:356-9. 2006..We also discuss a potential role for TFII-I in DNA repair and how it might be involved in signal dependent DNA repair versus cell cycle... - Determination and functional analysis of the consensus binding site for TFII-I family member BEN, implicated in Williams-Beuren syndromeMaria B Lazebnik
Programs in Genetics, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 283:11078-82. 2008.... - c-Src-dependent transcriptional activation of TFII-IVenugopalan Cheriyath
Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 277:22798-805. 2002..These data demonstrate that TFII-I, through a Src-dependent mechanism, reversibly translocates from the cytoplasm to the nucleus, leading to the transcriptional activation of growth-regulated genes... - Williams-Beuren syndrome-associated transcription factor TFII-I regulates osteogenic marker genesMaria B Lazebnik
Program in Genetics, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 284:36234-9. 2009..Identification of pathways regulated by TFII-I family transcription factors may begin to shed light on the molecular determinants of WBS... - Cutting Edge: TFII-I controls B cell proliferation via regulating NF-kappaBTodd Ashworth
Program in Immmunology, Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
J Immunol 178:2631-5. 2007..Thus, besides controlling c-myc transcription, TFII-I controls B cell proliferation by regulating both nuclear translocation of c-rel and DNA-binding activity of p50 NF-kappaB... - Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: role of TFII-I and its tyrosine phosphorylationMin Hong
Department of Biochemistry and Molecular Biology and the University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9176, USA
J Biol Chem 280:16821-8. 2005..Our studies provide a molecular link that connects the c-Src tyrosine kinase transduction pathway to ER stress-induced transcriptional activation of Grp78 mediated by TFII-I... - Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-IJaya Rajaiya
Oklahoma Medical Research Foundation, Immunobiology and Cancer Research Program, 825 N E 13th Street, Oklahoma City, OK 73104, USA
Mol Cell Biol 26:4758-68. 2006..These data suggest that Bright functions as a three-component protein complex in the immunoglobulin locus and tie together previous data indicating important roles for Btk and TFII-I in B lymphocytes... - Regulation of immunoglobulin promoter activity by TFII-I class transcription factorsDean Tantin
Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
J Biol Chem 279:5460-9. 2004..Dominant-negative and RNAi-mediated knockdown experiments indicate that BEN can both positively and negatively regulate IgH promoter activity, depending on the cell line... - An FF domain-dependent protein interaction mediates a signaling pathway for growth factor-induced gene expressionWei Jiang
Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
Mol Cell 17:23-35. 2005..These findings reveal a pathway by which mitogens promote gene transcription and indicate a role for FF domains in phosphorylation-mediated signal transduction... - The complex of TFII-I, PARP1, and SFPQ proteins regulates the DYX1C1 gene implicated in neuronal migration and dyslexiaIsabel Tapia-Paez
Department of Biosciences and Nutrition, 141 57 Huddinge, Karolinska Institute, Stockholm, Sweden
FASEB J 22:3001-9. 2008..Furthermore, allelic differences in the promoter or 5' untranslated region of DYX1C1 may affect factor binding and thus regulation of the gene... - Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-IYu Der Wen
H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
J Biol Chem 278:1841-7. 2003..These results suggest that HDAC3 modulates some of the functions of TFII-I and provides a link between histone deacetylase and a multifunctional transcriptional activator...