Ronenn Roubenoff

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi The effects of multidimensional home-based exercise on functional performance in elderly people
    Miriam E Nelson
    John Hancock Center for Physical Activity and Nutrition, Friedman School of Nutrition Science and Policy, Tufts University, Medford, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 59:154-60. 2004
  2. ncbi Applications of bioelectrical impedance analysis for body composition to epidemiologic studies
    R Roubenoff
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 64:459S-462S. 1996
  3. ncbi Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men
    Ronenn Roubenoff
    Department of Community Health, Jean Mayer US Department of Agriculture Human Nutrition Research Center, Tufts University, Boston, Massachusetts 02111, USA
    Am J Physiol Endocrinol Metab 283:E138-45. 2002
  4. ncbi Exercise, sarcopenia, cognition, and mood
    Ronenn Roubenoff
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nestle Nutr Workshop Ser Clin Perform Programme 6:151-9; discussion 160-2. 2002
  5. ncbi Reduction of abdominal obesity in lipodystrophy associated with human immunodeficiency virus infection by means of diet and exercise: case report and proof of principle
    Ronenn Roubenoff
    Department of Community Health, Tufts University School of Medicine, and Jean Mayer US Department of Agriculture Human Nutrition Research Center, Boston, Massachusetts 02111, USA
    Clin Infect Dis 34:390-3. 2002
  6. ncbi Effect of resistance training on self-reported physical functioning in HIV infection
    R Roubenoff
    Department of Community Health, Tufts University School of Medicine, Boston, MA, USA
    Med Sci Sports Exerc 33:1811-7. 2001
  7. ncbi The effect of gender and body composition method on the apparent decline in lean mass-adjusted resting metabolic rate with age
    R Roubenoff
    The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Gerontol A Biol Sci Med Sci 55:M757-60. 2000
  8. ncbi Sarcopenia: current concepts
    R Roubenoff
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Gerontol A Biol Sci Med Sci 55:M716-24. 2000
  9. ncbi Sarcopenia and its implications for the elderly
    R Roubenoff
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tuffs University, Boston, MA 02111, USA
    Eur J Clin Nutr 54:S40-7. 2000
  10. ncbi Sarcopenia: a major modifiable cause of frailty in the elderly
    R Roubenoff
    NEPS Laboratory, USDA HNRCA, 711 Washington Street, Boston, MA 02111, USA
    J Nutr Health Aging 4:140-2. 2000

Detail Information

Publications81

  1. ncbi The effects of multidimensional home-based exercise on functional performance in elderly people
    Miriam E Nelson
    John Hancock Center for Physical Activity and Nutrition, Friedman School of Nutrition Science and Policy, Tufts University, Medford, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 59:154-60. 2004
    ..This study tested the hypothesis that a home-based exercise program would improve functional performance in elderly people...
  2. ncbi Applications of bioelectrical impedance analysis for body composition to epidemiologic studies
    R Roubenoff
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 64:459S-462S. 1996
    ..BIA was a good predictor of DXA-derived FFM (r = 0.85-0.88, P < 0.001) and was superior to BMI as an estimator of body fat...
  3. ncbi Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men
    Ronenn Roubenoff
    Department of Community Health, Jean Mayer US Department of Agriculture Human Nutrition Research Center, Tufts University, Boston, Massachusetts 02111, USA
    Am J Physiol Endocrinol Metab 283:E138-45. 2002
    ..Even though weight loss was rare in this cohort of patients treated with highly active antiretroviral therapy, loss of LBM was common and was driven by catabolic cytokines and not by inadequate dietary intake or hypogonadism...
  4. ncbi Exercise, sarcopenia, cognition, and mood
    Ronenn Roubenoff
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nestle Nutr Workshop Ser Clin Perform Programme 6:151-9; discussion 160-2. 2002
  5. ncbi Reduction of abdominal obesity in lipodystrophy associated with human immunodeficiency virus infection by means of diet and exercise: case report and proof of principle
    Ronenn Roubenoff
    Department of Community Health, Tufts University School of Medicine, and Jean Mayer US Department of Agriculture Human Nutrition Research Center, Boston, Massachusetts 02111, USA
    Clin Infect Dis 34:390-3. 2002
    ..An exercise program combined with a moderate-fat, low-glycemic-index, high-fiber diet can reverse several aspects of lipodystrophy, and, until specific treatment is available, should be considered for treatment of lipodystrophy...
  6. ncbi Effect of resistance training on self-reported physical functioning in HIV infection
    R Roubenoff
    Department of Community Health, Tufts University School of Medicine, Boston, MA, USA
    Med Sci Sports Exerc 33:1811-7. 2001
    ....
  7. ncbi The effect of gender and body composition method on the apparent decline in lean mass-adjusted resting metabolic rate with age
    R Roubenoff
    The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Gerontol A Biol Sci Med Sci 55:M757-60. 2000
    ..Some, but not all, studies have shown that the decline in REE with age is eliminated after adjustment for fat-free mass (FFM)...
  8. ncbi Sarcopenia: current concepts
    R Roubenoff
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Gerontol A Biol Sci Med Sci 55:M716-24. 2000
    ..In this review, we discuss current concepts of the pathogenesis, treatment, and prevention of sarcopenia...
  9. ncbi Sarcopenia and its implications for the elderly
    R Roubenoff
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tuffs University, Boston, MA 02111, USA
    Eur J Clin Nutr 54:S40-7. 2000
    ....
  10. ncbi Sarcopenia: a major modifiable cause of frailty in the elderly
    R Roubenoff
    NEPS Laboratory, USDA HNRCA, 711 Washington Street, Boston, MA 02111, USA
    J Nutr Health Aging 4:140-2. 2000
    ..A major challenge in preventing an epidemic of sarcopenia-induced frailty in the future is developing public health interventions that deliver an anabolic stimulus to the muscle of elderly adults on a mass scale...
  11. ncbi Application of bioelectrical impedance analysis to elderly populations
    R Roubenoff
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, USA
    J Gerontol A Biol Sci Med Sci 52:M129-36. 1997
    ..However, it is not clear whether age-specific BIA equations are necessary for accurate application of BIA to research on elderly subjects...
  12. ncbi Monocyte cytokine production in an elderly population: effect of age and inflammation
    R Roubenoff
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, USA
    J Gerontol A Biol Sci Med Sci 53:M20-6. 1998
    ..To determine the association among aging, inflammation, and cytokine production by peripheral blood mononuclear cells...
  13. ncbi The relationship between growth hormone kinetics and sarcopenia in postmenopausal women: the role of fat mass and leptin
    R Roubenoff
    Nutrition Exercise Physiology and Sarcopenia Laboratory, Jean Mayer U S Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 83:1502-6. 1998
    ..67; P < 0.006). Although a causal relationship has not been demonstrated, these data suggest that leptin could modulate GH secretion through its action on the aging hypothalamic-pituitary axis, or that GH regulates leptin secretion...
  14. ncbi Effect of a single bout of acute exercise on plasma human immunodeficiency virus RNA levels
    R Roubenoff
    Department of Community Health, Department of Medicine, Tufts University School of Medicine, Boston 02111, Boston, Massachusetts 02111, USA
    J Appl Physiol (1985) 86:1197-201. 1999
    ....
  15. ncbi Short-term progressive resistance training increases strength and lean body mass in adults infected with human immunodeficiency virus
    R Roubenoff
    Department of Community Health, Tufts University School of Medicine, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    AIDS 13:231-9. 1999
    ..To assess the efficacy of progressive resistance training (PRT) in increasing strength and lean body mass (LBM) in HIV-infected adults...
  16. ncbi A pilot study of exercise training to reduce trunk fat in adults with HIV-associated fat redistribution
    R Roubenoff
    Department of Community Health, Tupper Research Institute, Tufts University School of Medicine, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    AIDS 13:1373-5. 1999
    ..At this time no effective treatment is available. We examined whether exercise training could reduce trunk fat in men with fat redistribution...
  17. ncbi Low physical activity reduces total energy expenditure in women with rheumatoid arthritis: implications for dietary intake recommendations
    Ronenn Roubenoff
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:774-9. 2002
    ..It is not known which effect predominates in regulating total energy expenditure (TEE), and thus whether the dietary energy requirements of subjects with RA are higher or lower than those of healthy subjects...
  18. ncbi Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study
    Ronenn Roubenoff
    United States Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Am J Med 115:429-35. 2003
    ..We hypothesized that these factors are independently linked to mortality in community-dwelling older persons...
  19. pmc Resistance training and timed essential amino acids protect against the loss of muscle mass and strength during 28 days of bed rest and energy deficit
    Naomi Brooks
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    J Appl Physiol (1985) 105:241-8. 2008
    ..These data support the efficacy of combined AA and RT as a countermeasure against muscle wasting due to low gravity...
  20. ncbi Age-related loss of associations between acute exercise-induced IL-6 and oxidative stress
    Jennifer M Sacheck
    Gerald J and Dorothy R Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Am J Physiol Endocrinol Metab 291:E340-9. 2006
    ....
  21. ncbi Anthropometric assessment of 10-y changes in body composition in the elderly
    Virginia A Hughes
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Am J Clin Nutr 80:475-82. 2004
    ..An increased central distribution of fat with advancing age is associated with chronic metabolic and cardiovascular abnormalities. Little is known about the magnitude or pattern of fat distribution and its association with healthy aging...
  22. ncbi Senescence of human skeletal muscle impairs the local inflammatory cytokine response to acute eccentric exercise
    Koichiro Hamada
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    FASEB J 19:264-6. 2005
    ..057) but not in old men. Our results suggest that aging impairs the adaptive response of human skeletal muscle to eccentric exercise by differential modulation of a discrete set of inflammatory and anti-inflammatory cytokine genes...
  23. ncbi Cytokine responses differ by compartment and wasting status in patients with HIV infection and healthy controls
    Leslie W Abad
    Department of Community Health, Tufts University School of Medicine, Boston, MA 02111, USA
    Cytokine 18:286-93. 2002
    ....
  24. pmc Tai Chi is effective in treating knee osteoarthritis: a randomized controlled trial
    Chenchen Wang
    Division of Rheumatology, Tufts Medical Center, Box 406, Tufts University School of Medicine, Boston, MA 02111, USA
    Arthritis Rheum 61:1545-53. 2009
    ..To evaluate the effectiveness of Tai Chi in the treatment of knee osteoarthritis (OA) symptoms...
  25. ncbi Eating behavior correlates of adult weight gain and obesity in healthy women aged 55-65 y
    Nicholas P Hays
    Jean Mayer US Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Boston 02111, USA
    Am J Clin Nutr 75:476-83. 2002
    ..The specific underlying causes of adult weight gain remain uncertain...
  26. pmc Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adults
    Lydia Sakakeeny
    Vitamin Metabolism Laboratory, Tufts University, Boston, MA, USA
    J Nutr 142:1280-5. 2012
    ..We discuss 2 possible roles for PLP in the inflammatory process, including tryptophan metabolism and serine hydroxymethyltransferase activity...
  27. pmc Dietary intakes of arachidonic acid and alpha-linolenic acid are associated with reduced risk of hip fracture in older adults
    Emily K Farina
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 141:1146-53. 2011
    ..04-0.96). No significant associations were observed among intakes of EPA, DHA, EPA+DHA, or fish. These findings suggest dietary ALA may reduce hip fracture risk in women and men and dietary AA may reduce hip fracture risk in men...
  28. ncbi Tumor necrosis factor-alpha production is associated with less body cell mass in women with rheumatoid arthritis
    Joseph Walsmith
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Rheumatol 31:23-9. 2004
    ..To examine the relationship between inflammatory cytokine production and body cell mass (BCM) in women with stable, medically well-controlled rheumatoid arthritis (RA)...
  29. ncbi Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study
    Hélène Payette
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Tufts University, Boston, Massachusetts, USA
    J Am Geriatr Soc 51:1237-43. 2003
    ..To assess the prognostic role of the inflammatory cytokine, interleukin 6 (IL-6), and insulin-like growth factor-1 (IGF-1) in predicting 2-year changes in fat-free mass (FFM) while controlling for potential confounders...
  30. ncbi Eating behavior and weight change in healthy postmenopausal women: results of a 4-year longitudinal study
    Nicholas P Hays
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 61:608-15. 2006
    ..However, the association of eating behavior with unexplained weight change in old age is relatively unexplored...
  31. ncbi Cachexia in rheumatoid arthritis is not explained by decreased growth hormone secretion
    Laura C Rall
    Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Arthritis Rheum 46:2574-7. 2002
    ..quot;..
  32. ncbi Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis
    En Pei I Chiang
    Vitamin Metabolism and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Med 114:283-7. 2003
    ..We examined whether these abnormalities are associated with clinical and biochemical indicators of disease status...
  33. pmc Durability of the effects of testosterone and growth hormone supplementation in older community-dwelling men: the HORMA Trial
    Fred R Sattler
    Department of Medicine, University of Southern CaliforniaDivision of Biokinesiology, University of Southern California, Los Angeles, CASection of Endocrinology, Diabetes, and Nutrition, Boston University, Boston, MADepartment of Preventive Medicine, University of Southern California, Los Angeles, CADepartment of Medicine, Washington University, St Louis, MOJean Mayer USDA Human Nutrition Research Center on Aging of Tufts University, Boston, MADepartment of Urology, University of Southern California, Los Angeles, CA, USA
    Clin Endocrinol (Oxf) 75:103-11. 2011
    ..To determine the durability of anabolic effects and adverse events (AEs) after stopping testosterone and growth hormone supplementation in older men...
  34. pmc Plasma phosphatidylcholine concentrations of polyunsaturated fatty acids are differentially associated with hip bone mineral density and hip fracture in older adults: the Framingham Osteoporosis Study
    Emily K Farina
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Bone Miner Res 27:1222-30. 2012
    ..00). Opposing effects of PC DHA on FN-BMD loss observed in women and men need further clarification. Bone loss associated with PC LA may be confounded by BMI. High PC AA concentrations may be associated with reduced hip fracture risk...
  35. pmc Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes
    Naomi Brooks
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Int J Med Sci 4:19-27. 2007
    ..However, these data show that strength training is an exercise modality to consider as an adjunct of standard of care in high risk populations with type 2 diabetes...
  36. pmc Muscle fiber size and function in elderly humans: a longitudinal study
    Walter R Frontera
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    J Appl Physiol (1985) 105:637-42. 2008
    ..This suggests that surviving fibers compensate to partially correct muscle size deficits in an attempt to maintain optimal force-generating capacity...
  37. ncbi Metabolic aging and predicted longevity: results of a cross-sectional study in post-menopausal women
    Nicholas P Hays
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Aging Clin Exp Res 14:465-73. 2002
    ..The objective of this study was to examine the association of age-related physiological and metabolic variables with predicted longevity in postmenopausal women...
  38. ncbi Longitudinal changes in body composition in older men and women: role of body weight change and physical activity
    Virginia A Hughes
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:473-81. 2002
    ..Estimates of body-composition change in older adults are mostly derived from cross-sectional data...
  39. ncbi Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status
    Sarah L Booth
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 80:143-8. 2004
    ..Although a vitamin E-vitamin K interaction was proposed to underlie this effect, it has not been systematically investigated in adults with normal baseline coagulation status...
  40. ncbi Resistance training to reduce the malnutrition-inflammation complex syndrome of chronic kidney disease
    Carmen Castaneda
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Kidney Dis 43:607-16. 2004
    ..Systemic inflammation and protein-energy malnutrition may be associated with poor outcomes in kidney disease...
  41. pmc Whole-body and muscle protein metabolism are not affected by acute deviations from habitual protein intake in older men: the Hormonal Regulators of Muscle and Metabolism in Aging (HORMA) Study
    Kevin E Yarasheski
    Department of Medicine, Washington University, St Louis, MO, USA
    Am J Clin Nutr 94:172-81. 2011
    ..Acute deviations in protein intake before the quantification of protein kinetics in older humans may explain the controversy over the effects of older age on muscle protein synthesis and proteolysis rates...
  42. ncbi Strength training in older women: early and late changes in whole muscle and single cells
    Walter R Frontera
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Muscle Nerve 28:601-8. 2003
    ..Later, cellular adaptations in specific force track closely whole muscle changes...
  43. doi Erroneous augmentation of multiplex assay measurements in patients with rheumatoid arthritis due to heterophilic binding by serum rheumatoid factor
    Derrick J Todd
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Arthritis Rheum 63:894-903. 2011
    ..The purpose of this study was to assess whether these factors confound multiplex-based immunoassays, which are used with increasing frequency to measure cytokine and chemokine analytes in patients with rheumatoid arthritis (RA)...
  44. ncbi Preliminary evidence shows that folic acid fortification of the food supply is associated with higher methotrexate dosing in patients with rheumatoid arthritis
    Senada Arabelovic
    US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Am Coll Nutr 26:453-5. 2007
    ..However, an increase in dietary folate intake could theoretically reduce the effectiveness of the anti-folate medication, methotrexate (MTX) in treating rheumatoid arthritis (RA) and other inflammatory diseases...
  45. ncbi Physical activity, inflammation, and muscle loss
    Ronenn Roubenoff
    School of Medicine, Tufts University, Boston, Massachusetts, USA
    Nutr Rev 65:S208-12. 2007
    ..Without a doubt, exercise is an intervention that reliably counteracts the loss of muscle mass, strength, and power common in our increasingly aged, and pervasively sedentary, population...
  46. pmc Tai Chi for treating knee osteoarthritis: designing a long-term follow up randomized controlled trial
    Chenchen Wang
    Division of Rheumatology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
    BMC Musculoskelet Disord 9:108. 2008
    ..The study will be completed by July 2009...
  47. ncbi Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men
    Jennifer M Sacheck
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 34:1575-88. 2003
    ....
  48. ncbi A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes
    Carmen Castaneda
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Diabetes Care 25:2335-41. 2002
    ..To determine the efficacy of high-intensity progressive resistance training (PRT) on glycemic control in older adults with type 2 diabetes...
  49. ncbi The healthcare costs of sarcopenia in the United States
    Ian Janssen
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    J Am Geriatr Soc 52:80-5. 2004
    ..To estimate the healthcare costs of sarcopenia in the United States and to examine the effect that a reduced sarcopenia prevalence would have on healthcare expenditures...
  50. pmc Testosterone threshold levels and lean tissue mass targets needed to enhance skeletal muscle strength and function: the HORMA trial
    Fred Sattler
    Department of Medicine, University of Southern California, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
    J Gerontol A Biol Sci Med Sci 66:122-9. 2011
    ....
  51. ncbi Mixed patterns of changes in central and peripheral fat following initiation of antiretroviral therapy in a randomized trial
    Kathleen Mulligan
    Department of Medicine, Division of Endocrinology, San Francisco General Hospital, University of California at San Francisco, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 41:590-7. 2006
    ..We examined intraindividual changes in dual-energy x-ray absorptiometry (DEXA) and anthropometry data over 64 weeks after initiation of antiretroviral therapy (ART)...
  52. ncbi Sarcopenia: effects on body composition and function
    Ronenn Roubenoff
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 58:1012-7. 2003
    ..In this review, I discuss the potential mechanisms of sarcopenia and some ideas about prevention and treatment...
  53. ncbi Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status
    En Pei I Chiang
    Vitamin Metabolism and Aging Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 133:1056-9. 2003
    ..420, P = 0.015 and r = 0.333, P = 0.05, respectively). We suggest that in patients with RA, plasma PLP levels are a better diagnostic indicator of functional vitamin B-6 status than erythrocyte PLP levels...
  54. ncbi Energy expenditure in critically ill children
    Christine M Hardy Framson
    Division of Pediatric Gastroenterology, Nutrition, and Liver Diseases, Hasbro Children s Hospital at Rhode Island Hospital, Providence, RI, USA
    Pediatr Crit Care Med 8:264-7. 2007
    ..A secondary aim was to compare the accuracy of a newly derived prediction equation specific to the pediatric intensive care unit and the measured resting energy expenditure...
  55. pmc Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study
    Emily K Farina
    Friedman School of Nutrition Science and Policy, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02115, USA
    Am J Clin Nutr 93:1142-51. 2011
    ..Polyunsaturated fatty acids and fish may influence bone health...
  56. ncbi Cachexia in rheumatoid arthritis
    Joseph Walsmith
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Int J Cardiol 85:89-99. 2002
    ..In this review, we outline the current definition of rheumatoid cachexia, and discuss the etiology, pathogenesis, and treatment of rheumatoid cachexia...
  57. pmc Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men
    Joel O Olubodun
    Department of Pharmacology and Experimental Therapeutics and the Jean Mayer USDA Human Nutrition Research Center on Ageing, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Br J Clin Pharmacol 56:297-304. 2003
    ..The influence of ageing on the pharmacokinetics of zolpidem, an extensively prescribed hypnotic medication, was evaluated in healthy human volunteers...
  58. ncbi Exercise and inflammatory disease
    Ronenn Roubenoff
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Arthritis Rheum 49:263-6. 2003
  59. pmc Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis
    Jing Cui
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Med 15:136-43. 2009
    ..We identified a SNP in moderate linkage disequilibrium (LD) with HLA-DR3, which may influence anti-CCP titer independently of the HLA-SE...
  60. ncbi The association of eating behavior with risk for morbidity in older women
    Nicholas P Hays
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Gerontol A Biol Sci Med Sci 57:M128-33. 2002
    ..Although an influence of eating behavior on dietary intake and physiology has been documented in several studies, the extent to which eating behavior influences long-term health is uncertain...
  61. ncbi Catabolism of aging: is it an inflammatory process?
    Ronenn Roubenoff
    Department of Molecular Medicine, Millennium Pharmaceuticals Inc, Cambridge, Massachusetts 02139, USA
    Curr Opin Clin Nutr Metab Care 6:295-9. 2003
    ..This review focuses on recent developments in the field, especially regarding the role of catabolic stimuli in causing sarcopenia...
  62. ncbi Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study
    Ramachandran S Vasan
    Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Circulation 107:1486-91. 2003
    ..It is unclear whether cytokine levels can predict the incidence of CHF in asymptomatic individuals...
  63. ncbi Sarcopenic obesity: the confluence of two epidemics
    Ronenn Roubenoff
    Molecular Medicine, Millennium Pharmaceuticals Cambridge, MA 02139, USA
    Obes Res 12:887-8. 2004
  64. ncbi Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate
    Alex Parker
    Millennium Pharmaceuticals Inc, Cambridge, Massachusetts, USA
    J Rheumatol 34:1817-22. 2007
    ..We analyzed association of gene expression with disease activity, rheumatoid factor (RF), age, sex, disease duration, treatment modality, and clinical response...
  65. pmc Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis
    En Pei I Chiang
    Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, Taiwan 402, Republic of China
    Arthritis Res Ther 7:R1404-11. 2005
    ..Data from the present study suggest that patients with rheumatoid arthritis may have higher requirements for vitamin B6 than those in a normal healthy population...
  66. pmc GH peak response to GHRH-arginine: relationship to insulin resistance and other cardiovascular risk factors in a population of adults aged 50-90
    John D Carmichael
    Neuroendocrine Unit, Division of Endocrinology, General Clinical Research Center, New York University School of Medicine, New York, NY, USA
    Clin Endocrinol (Oxf) 65:169-77. 2006
    ..To assess the GH response to GHRH-arginine in apparently healthy adults in relation to cardiovascular risk factors...
  67. ncbi Effects of potent antiretroviral therapy on free testosterone levels and fat-free mass in men in a prospective, randomized trial: A5005s, a substudy of AIDS Clinical Trials Group Study 384
    Michael P Dube
    Division of Infectious Diseases, Indiana University, Indianapolis, USA
    Clin Infect Dis 45:120-6. 2007
    ..The effects of initiation of different antiretroviral regimens on testosterone levels and changes in fat-free mass have not been reported...
  68. pmc Inflammation causes tissue-specific depletion of vitamin B6
    En Pei Chiang
    Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan
    Arthritis Res Ther 7:R1254-62. 2005
    ..The low plasma pyridoxal 5'-phosphate levels seen in inflammation are unlikely to be due to insufficient intake or excessive vitamin B6 excretion. Possible causes of decreased levels of vitamin B6 are discussed...
  69. ncbi Glucose metabolism, lipid, and body fat changes in antiretroviral-naive subjects randomized to nelfinavir or efavirenz plus dual nucleosides
    Michael P Dube
    Division of Infectious Diseases, Indiana University, Indianapolis, Indiana, USA
    AIDS 19:1807-18. 2005
    ..To determine if particular components of antiretroviral drug regimens are associated with greater insulin resistance, dyslipidemia, and peripheral lipoatrophy...
  70. ncbi Monocyte cytokine production, systemic inflammation and cardiovascular disease in very elderly men and women: the Framingham Heart Study
    Agha W Haider
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702 5827, USA
    Eur J Cardiovasc Prev Rehabil 11:214-5. 2004
    ..Further studies are warranted to examine the prognostic implications of CRP and related cytokines for CVD in the elderly...
  71. ncbi Use of mass spectrometry to identify protein biomarkers of disease severity in the synovial fluid and serum of patients with rheumatoid arthritis
    Hua Liao
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Arthritis Rheum 50:3792-803. 2004
    ..To identify a panel of candidate protein biomarkers of rheumatoid arthritis (RA) that can predict which patients will develop erosive, disabling disease...
  72. ncbi The role of cytokines in regulating protein metabolism and muscle function
    Elena Zoico
    Cattedra di Geriatria, Universita di Verona, Italy
    Nutr Rev 60:39-51. 2002
    ..Even though several gaps remain in our understanding, these observations may be useful in the development of strategies to control protein metabolism and muscle function in different clinical conditions...
  73. ncbi Exercise training alters skeletal muscle mitochondrial morphometry in heart failure patients
    Cheryl Santoro
    University of Connecticut, School of Allied Health, Storrs, CT, USA
    J Cardiovasc Risk 9:377-81. 2002
    ..Previous research has demonstrated that exercise intolerance in heart failure patients is associated with significant alterations in skeletal muscle ultrastructure and oxidative metabolism that may be more consequential than cardiac output...
  74. ncbi Work Group recommendations: 2002 Exercise and Physical Activity Conference, St Louis, Missouri
    Rowland Chang
    Northwestern University, Evanston, Illinois, USA
    Arthritis Rheum 49:280. 2003
  75. ncbi Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women
    Ian Janssen
    Department of Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Am J Epidemiol 159:413-21. 2004
    ....
  76. pmc Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis
    Chunyu Liu
    Biogen Idec Inc, Cambridge, Massachusetts, USA
    Mol Med 14:575-81. 2008
    ..Replications of these results in independent and larger data sets clearly are required. We provide a reference list of candidate SNPs (P < 0.01) that can be investigated in future pharmacogenomic studies...
  77. doi Excess baggage: sarcopenia, obesity, and cancer outcomes
    Ronenn Roubenoff
    Lancet Oncol 9:605-7. 2008
  78. ncbi Long-term body fat outcomes in antiretroviral-naive participants randomized to nelfinavir or efavirenz or both plus dual nucleosides. Dual X-ray absorptiometry results from A5005s, a substudy of Adult Clinical Trials Group 384
    Michael P Dube
    Division of Infectious Diseases, Indiana University, Indianapolis, USA
    J Acquir Immune Defic Syndr 45:508-14. 2007
    ..Long-term regional body fat outcomes have not been well described in randomized antiretroviral drug trials...
  79. ncbi Hormonal regulators of muscle and metabolism in aging (HORMA): design and conduct of a complex, double masked multicenter trial
    E Todd Schroeder
    Division of Biokinesiology, University of Southern California, Los Angeles, CA 90033, USA
    Clin Trials 4:560-71. 2007
    ..This report describes the challenges of conducting a complex clinical investigation assessing the effects of anabolic hormones on body composition, physical function, and metabolism during aging...
  80. ncbi Biological significance of anti-cyclic citrullinated peptide antibody in rheumatoid arthritis
    Ronenn Roubenoff
    Ann Intern Med 148:403; author reply 403-4. 2008
  81. pmc Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    Robert M Plenge
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1477-82. 2007
    ..We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23...