Joseph Polak

Summary

Affiliation: Tufts Medical Center
Country: USA

Publications

  1. ncbi Intima-media thickness: a tool for atherosclerosis imaging and event prediction
    Joseph F Polak
    Department of Radiology, Tufts New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 90:18L-21L. 2002
  2. ncbi The value of carotid artery plaque and intima-media thickness for incident cardiovascular disease: the multi-ethnic study of atherosclerosis
    Joseph F Polak
    Ultrasound Reading Center, Department of Radiology, Tufts Medical Center, Boston, MA
    J Am Heart Assoc 2:e000087. 2013
  3. ncbi Carotid Artery Plaque and Progression of Coronary Artery Calcium: The Multi-Ethnic Study of Atherosclerosis
    Joseph F Polak
    Ultrasound Reading Center, Department of Radiology, Tufts Medical Center, Boston, Massachusetts Electronic address
    J Am Soc Echocardiogr 26:548-55. 2013
  4. ncbi Variations in common carotid artery intima-media thickness during the cardiac cycle: implications for cardiovascular risk assessment
    Joseph F Polak
    Tufts Medical Center, Department of Radiology, 800 Washington Street, Box 299, Boston, MA 02111, USA
    J Am Soc Echocardiogr 25:1023-8. 2012
  5. ncbi Carotid intima-media thickness: an early marker of cardiovascular disease
    Joseph F Polak
    Ultrasound Reading Center, Tufts Medical Center and Professor of Radiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Ultrasound Q 25:55-61. 2009
  6. ncbi Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT
    Joseph F Polak
    Department of Radiology, Tufts Medical Center, Boston, MA 02111, USA
    J Ultrasound Med 29:1759-68. 2010
  7. ncbi Associations of edge-detected and manual-traced common carotid intima-media thickness measurements with Framingham risk factors: the multi-ethnic study of atherosclerosis
    Joseph F Polak
    Department of Radiology, 299, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Stroke 42:1912-6. 2011
  8. ncbi Inter-reader differences in common carotid artery intima-media thickness: implications for cardiovascular risk assessment and vascular age determination
    Joseph F Polak
    Department of Radiology, Tufts Medical Center, 800 Washington St, Box 299, Boston, MA 02111, USA
    J Ultrasound Med 30:915-20. 2011
  9. ncbi Associations of cardiovascular risk factors, carotid intima-media thickness and left ventricular mass with inter-adventitial diameters of the common carotid artery: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Joseph F Polak
    Department of Radiology, Tufts Medical Center, Boston, MA, USA
    Atherosclerosis 218:344-9. 2011
  10. ncbi Carotid-wall intima-media thickness and cardiovascular events
    Joseph F Polak
    Department of Radiology, Tufts Medical Center, Boston, MA 02111, USA
    N Engl J Med 365:213-21. 2011

Research Grants

  1. Epidemiology of Carotid Intima-Medial Thickness (IMT) in Atherosclerosis
    Joseph Polak; Fiscal Year: 2007
  2. Progression of sub-clinical Atherosclerosis
    Joseph Polak; Fiscal Year: 2007
  3. Progression of sub-clinical Atherosclerosis
    Joseph Polak; Fiscal Year: 2009

Detail Information

Publications24

  1. ncbi Intima-media thickness: a tool for atherosclerosis imaging and event prediction
    Joseph F Polak
    Department of Radiology, Tufts New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 90:18L-21L. 2002
    ..However, uncertainty about which measure of IMT offers the best end point has inhibited methodologic standardization...
  2. ncbi The value of carotid artery plaque and intima-media thickness for incident cardiovascular disease: the multi-ethnic study of atherosclerosis
    Joseph F Polak
    Ultrasound Reading Center, Department of Radiology, Tufts Medical Center, Boston, MA
    J Am Heart Assoc 2:e000087. 2013
    ..We evaluated various ultrasound definitions of carotid artery plaque as predictors of future cardiovascular disease (CVD) and coronary heart disease (CHD) events...
  3. ncbi Carotid Artery Plaque and Progression of Coronary Artery Calcium: The Multi-Ethnic Study of Atherosclerosis
    Joseph F Polak
    Ultrasound Reading Center, Department of Radiology, Tufts Medical Center, Boston, Massachusetts Electronic address
    J Am Soc Echocardiogr 26:548-55. 2013
    ..The aim of this study was to evaluate whether carotid artery plaque seen on carotid ultrasound can predict incident coronary artery calcification (CAC)...
  4. ncbi Variations in common carotid artery intima-media thickness during the cardiac cycle: implications for cardiovascular risk assessment
    Joseph F Polak
    Tufts Medical Center, Department of Radiology, 800 Washington Street, Box 299, Boston, MA 02111, USA
    J Am Soc Echocardiogr 25:1023-8. 2012
    ..Common carotid artery intima-media thickness (IMT), a measure of atherosclerosis, varies between peak systole and end-diastole. This difference might affect cardiovascular risk assessment...
  5. ncbi Carotid intima-media thickness: an early marker of cardiovascular disease
    Joseph F Polak
    Ultrasound Reading Center, Tufts Medical Center and Professor of Radiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Ultrasound Q 25:55-61. 2009
    ..This paper reviews the basic history of the development of carotid artery IMT measurements and discusses some technical aspects of the measurement...
  6. ncbi Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT
    Joseph F Polak
    Department of Radiology, Tufts Medical Center, Boston, MA 02111, USA
    J Ultrasound Med 29:1759-68. 2010
    ..The goal of this study was to compare internal carotid artery (ICA) intima-media thickness (IMT) with common carotid artery (CCA) IMT as global markers of cardiovascular disease (CVD)...
  7. ncbi Associations of edge-detected and manual-traced common carotid intima-media thickness measurements with Framingham risk factors: the multi-ethnic study of atherosclerosis
    Joseph F Polak
    Department of Radiology, 299, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Stroke 42:1912-6. 2011
    ..In most outcome studies, human readers identify and trace the key IMT interfaces. We evaluate an alternate approach using automated edge detection...
  8. ncbi Inter-reader differences in common carotid artery intima-media thickness: implications for cardiovascular risk assessment and vascular age determination
    Joseph F Polak
    Department of Radiology, Tufts Medical Center, 800 Washington St, Box 299, Boston, MA 02111, USA
    J Ultrasound Med 30:915-20. 2011
    ..Vascular age is derived from intima-media thickness measurements. We studied how tracing the wall interfaces affects intima-media thickness measurements and estimates of vascular age...
  9. ncbi Associations of cardiovascular risk factors, carotid intima-media thickness and left ventricular mass with inter-adventitial diameters of the common carotid artery: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Joseph F Polak
    Department of Radiology, Tufts Medical Center, Boston, MA, USA
    Atherosclerosis 218:344-9. 2011
    ..IAD may be associated with left ventricular mass (LV mass) while IMT is a marker of subclinical atherosclerosis. It is not clear if IAD is associated with LV mass after accounting for IMT and traditional cardiovascular risk factors...
  10. ncbi Carotid-wall intima-media thickness and cardiovascular events
    Joseph F Polak
    Department of Radiology, Tufts Medical Center, Boston, MA 02111, USA
    N Engl J Med 365:213-21. 2011
    ..Intima-media thickness of the walls of the common carotid artery and internal carotid artery may add to the Framingham risk score for predicting cardiovascular events...
  11. ncbi Common carotid artery intima-media thickness progression as a predictor of stroke in multi-ethnic study of atherosclerosis
    Joseph F Polak
    Department of Radiology, 299, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Stroke 42:3017-21. 2011
    ..Carotid artery intima-media thickness (IMT) is a marker of cardiovascular disease associated with incident stroke. We studied whether IMT rate of change is associated with stroke...
  12. ncbi Segment-specific associations of carotid intima-media thickness with cardiovascular risk factors: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    Joseph F Polak
    Department of Radiology, 299, Tufts Medical Center, 800 Washington St, Boston, MA 02111, USA
    Stroke 41:9-15. 2010
    ....
  13. ncbi Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the Framingham Heart Study offspring cohort
    Renke Maas
    Department of Neurology, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Stroke 40:2715-9. 2009
    ..We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT...
  14. ncbi Micronutrient concentrations and subclinical atherosclerosis in adults with HIV
    E Liana Falcone
    Department of Medicine, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Am J Clin Nutr 91:1213-9. 2010
    ..Extremes in micronutrient intakes are common in HIV-infected patients in developed countries and may affect the progression of atherosclerosis in this population...
  15. ncbi Framingham risk score and early markers of atherosclerosis in a cohort of adults infected with HIV
    E Liana Falcone
    Department of Medicine, Tufts Medical Center, Boston, MA, USA
    Antivir Ther 16:1-8. 2011
    ..We examined the association of Framingham risk scores with surrogate markers of atherosclerosis in a carefully characterized cohort of adults infected with HIV...
  16. ncbi Alcohol consumption and carotid atherosclerosis in older adults: the Cardiovascular Health Study
    Kenneth J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Ave, RO 114, Boston, Mass 02215, USA
    Arterioscler Thromb Vasc Biol 23:2252-9. 2003
    ..The association of alcohol use with atherosclerosis is inconsistent in previous studies...
  17. ncbi Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study
    Jose R Romero
    Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
    J Stroke Cerebrovasc Dis 17:412-7. 2008
    ..We sought to relate circulating biomarkers of extracellular matrix turnover to site-specific measures of carotid artery atherosclerosis on duplex ultrasound...
  18. ncbi Metabolic syndrome and subclinical atherosclerosis in patients infected with HIV
    Alexandra Mangili
    Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Clin Infect Dis 44:1368-74. 2007
    ..The present study examines the association between carotid and coronary atherosclerosis and metabolic syndrome in human immunodeficiency virus (HIV)-infected adults...
  19. ncbi Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study
    Jose R Romero
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 40:1590-6. 2009
    ..The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear...
  20. ncbi Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study
    Roberto Elosua
    US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 47:990-6. 2006
    ..APOA5 variants were associated with CCA IMT, particularly in obese participants. The mechanism of these associations and the effect modification by obesity are independent of fasting triglyceride levels...
  21. ncbi Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study
    Roberto Elosua
    The Department of Biostatistics, Boston University, Boston, MA, United States The USDA Human Nutrition Research Center on Aging, Tufts University, MA, USA
    Atherosclerosis 189:222-8. 2006
    ..To determine the association of well-characterized lipoprotein-related genetic variants with carotid intimal medial thickness (IMT) and stenosis...
  22. ncbi Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study
    Rohit R Das
    Department of Neurology, Boston University, Boston, MA 02118, USA
    Stroke 39:2929-35. 2008
    ..8% and 17.7% depending on age, ethnicity, presence of comorbidities, and imaging techniques. We document the prevalence and risk factors associated with SCI at midlife in the community-based Framingham sample...
  23. ncbi Prospective evaluation of the role of atherosclerosis on cerebral atrophy: pilot study
    Sami H Erbay
    Radiology Department, Tufts New England Medical Center, Boston, MA 02111, USA
    J Neuroimaging 18:375-80. 2008
    ..Our purpose was to study the association between atherosclerosis measured by arterial calcium on computed tomography (CT) and cerebral atrophy demonstrated by brain magnetic resonance imaging (MRI)...
  24. ncbi Dietary patterns and the odds of carotid atherosclerosis in women: the Framingham Nutrition Studies
    Barbara E Millen
    Department of Social and Behavioral Sciences, Boston University School of Public Health, Room 263W, 715 Albany Street, Boston, MA 02118, USA
    Prev Med 35:540-7. 2002
    ..We prospectively examined the relationship between dietary patterns, assessed using cluster analysis and a food frequency questionnaire, and the presence of carotid artery stenosis, a subclinical marker of atherosclerotic disease...

Research Grants10

  1. Epidemiology of Carotid Intima-Medial Thickness (IMT) in Atherosclerosis
    Joseph Polak; Fiscal Year: 2007
    ..As compared to previous published works on the topic, this application offers the opportunity of measuring atherosclerosis across a broad age distribution and in a multi-ethnic cohort using state-of-the-art technologies. ..
  2. Progression of sub-clinical Atherosclerosis
    Joseph Polak; Fiscal Year: 2007
    ..This complements ongoing research on the progression of sub-clinical cardiovascular disease and its associations with family history of premature cardiovascular events and genomic markers. ..
  3. Progression of sub-clinical Atherosclerosis
    Joseph Polak; Fiscal Year: 2009
    ..This complements ongoing research on the progression of sub-clinical cardiovascular disease and its associations with family history of premature cardiovascular events and genomic markers. ..