Jose Ordovas

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi Gender, a significant factor in the cross talk between genes, environment, and health
    Jose M Ordovas
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Gend Med 4:S111-22. 2007
  2. ncbi A clustering analysis of lipoprotein diameters in the metabolic syndrome
    Alexis C Frazier-Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, USA
    Lipids Health Dis 10:237. 2011
  3. ncbi High-fat meal effect on LDL, HDL, and VLDL particle size and number in the Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN): an interventional study
    Mary K Wojczynski
    Department of Biostatistics, University of Alabama at Birmingham, Brimingham, AL, USA
    Lipids Health Dis 10:181. 2011
  4. ncbi Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS
    Alexis C Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, Alabama, USA
    Lipids Health Dis 10:143. 2011
  5. ncbi Clinical characteristics and evaluation of LDL-cholesterol treatment of the Spanish Familial Hypercholesterolemia Longitudinal Cohort Study (SAFEHEART)
    Nelva Mata
    Department of Epidemiology, Madrid Health Authority and Fundación Hipercolesterolemia Familiar, Madrid, Spain
    Lipids Health Dis 10:94. 2011
  6. ncbi TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate
    Edmond K Kabagambe
    Department of Epidemiology, School of Public Health and Clinical Nutrition Research Center, University of Alabama, Birmingham, AL 35294, USA
    Diabetol Metab Syndr 1:16. 2009
  7. ncbi The Boston Puerto Rican Health Study, a longitudinal cohort study on health disparities in Puerto Rican adults: challenges and opportunities
    Katherine L Tucker
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    BMC Public Health 10:107. 2010
  8. ncbi A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007
  9. ncbi Ten commandments for the future of ageing research in the UK: a vision for action
    Oscar H Franco
    BMC Geriatr 7:10. 2007
  10. ncbi A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS
    Kris Richardson
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    BMC Genomics 12:504. 2011

Research Grants

  1. PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTH
    Jose Ordovas; Fiscal Year: 2009
  2. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 2009
  3. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 2007
  4. PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTH
    Jose Ordovas; Fiscal Year: 2007
  5. Vitamin K: Genetics of Vascular Calcification
    Jose Ordovas; Fiscal Year: 2005
  6. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 2004
  7. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 1999
  8. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose M Ordovas; Fiscal Year: 2010

Detail Information

Publications98

  1. ncbi Gender, a significant factor in the cross talk between genes, environment, and health
    Jose M Ordovas
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Gend Med 4:S111-22. 2007
    ..Sex influences the risk of nearly all common diseases that affect both men and women, including atherosclerosis and diabetes and their preceding risk factors (eg, hyperlipidemia, insulin resistance, and obesity)...
  2. ncbi A clustering analysis of lipoprotein diameters in the metabolic syndrome
    Alexis C Frazier-Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, USA
    Lipids Health Dis 10:237. 2011
    ....
  3. ncbi High-fat meal effect on LDL, HDL, and VLDL particle size and number in the Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN): an interventional study
    Mary K Wojczynski
    Department of Biostatistics, University of Alabama at Birmingham, Brimingham, AL, USA
    Lipids Health Dis 10:181. 2011
    ..Analyses were stratified by baseline triglycerides (normal vs. elevated) and gender. The effect of PPL on changes in lipoprotein subclasses was assessed using repeated measures ANOVA...
  4. ncbi Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS
    Alexis C Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, Alabama, USA
    Lipids Health Dis 10:143. 2011
    ....
  5. ncbi Clinical characteristics and evaluation of LDL-cholesterol treatment of the Spanish Familial Hypercholesterolemia Longitudinal Cohort Study (SAFEHEART)
    Nelva Mata
    Department of Epidemiology, Madrid Health Authority and Fundación Hipercolesterolemia Familiar, Madrid, Spain
    Lipids Health Dis 10:94. 2011
    ..Despite the use of statins, most patients do not achieve an optimal LDL-cholesterol goal. The aims of this study are to describe baseline characteristics and to evaluate Lipid Lowering Therapy (LLT) in FH patients recruited in SAFEHEART...
  6. ncbi TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate
    Edmond K Kabagambe
    Department of Epidemiology, School of Public Health and Clinical Nutrition Research Center, University of Alabama, Birmingham, AL 35294, USA
    Diabetol Metab Syndr 1:16. 2009
    ....
  7. ncbi The Boston Puerto Rican Health Study, a longitudinal cohort study on health disparities in Puerto Rican adults: challenges and opportunities
    Katherine L Tucker
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    BMC Public Health 10:107. 2010
    ....
  8. ncbi A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007
    ..Genome-wide association is a promising approach to map genetic loci related to these heritable phenotypes...
  9. ncbi Ten commandments for the future of ageing research in the UK: a vision for action
    Oscar H Franco
    BMC Geriatr 7:10. 2007
    ....
  10. ncbi A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS
    Kris Richardson
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    BMC Genomics 12:504. 2011
    ....
  11. ncbi Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites
    Josiemer Mattei
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    BMC Genet 10:45. 2009
    ....
  12. ncbi Metagenomics: the role of the microbiome in cardiovascular diseases
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 17:157-61. 2006
    ..Investigation of such complex ecosystems and interactions has been difficult. In this paper, we assess the current evidence supporting the role of the microbiota as a significant determinant of cardiovascular disease risk...
  13. ncbi Nutrient-gene interactions in lipoprotein metabolism - an overview
    Jose M Ordovas
    Nutrition and Genomics Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Forum Nutr 60:102-9. 2007
  14. ncbi Identification of a functional polymorphism at the adipose fatty acid binding protein gene (FABP4) and demonstration of its association with cardiovascular disease: a path to follow
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Meyer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Nutr Rev 65:130-4. 2007
    ..In this regard, genetic variability at the FABP4 locus has been shown to be associated with plasma lipid levels, type 2 diabetes, and coronary heart disease risk...
  15. ncbi Gene-environment interactions and susceptibility to metabolic syndrome and other chronic diseases
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Periodontol 79:1508-13. 2008
    ..Once further experience is gained from patients and/or individuals at high risk, more personalized genetic-based approaches may be applied toward the primary prevention and treatment of CVDs and other complex inflammatory diseases...
  16. ncbi Nutrigenetics, plasma lipids, and cardiovascular risk
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Am Diet Assoc 106:1074-81; quiz 1083. 2006
    ....
  17. ncbi Genetic interactions with diet influence the risk of cardiovascular disease
    Jose M Ordovas
    Tufts University Sackler School of Graduate Biomedical Sciences, The Gerald J and Dorothy R Friedman School of Nutrition Science and Policy, Boston, MA 02111 1524, USA
    Am J Clin Nutr 83:443S-446S. 2006
    ..The nascent science of nutrigenomics faces many challenges; more and better research is needed to clarify the picture, rebut scepticism, and re-invigorate the discussion concerning genetic polymorphism and its interaction with diet...
  18. ncbi Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet
    Dolores Corella
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Diabetes Care 29:1313-9. 2006
    ..To investigate the association between genetic variation in the adipocyte protein perilipin (PLIN) and insulin resistance in an Asian population as well as to examine their modulation by macronutrient intake...
  19. ncbi Nutrition in the genomics era: cardiovascular disease risk and the Mediterranean diet
    Jose M Ordovas
    Nutrition and Genomics Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Mol Nutr Food Res 51:1293-9. 2007
    ..This knowledge may provide the basis for successful public health as well individual approaches for disease prevention...
  20. ncbi Diet/genetic interactions and their effects on inflammatory markers
    Jose Ordovas
    Tufts University Sackler School of Graduate Biomedical Sciences, Tufts University, Boston Massachusetts 02111 1524, USA
    Nutr Rev 65:S203-7. 2007
    ..Whether these interactions translate into healthier aging and increased longevity remains to be determined; however, the prospects are enticing...
  21. ncbi Genetic links between diabetes mellitus and coronary atherosclerosis
    Jose M Ordovas
    Nutrition and Genetics, JM USDA HNRCA at Tufts University, Boston, MA 02111, USA
    Curr Atheroscler Rep 9:204-10. 2007
    ....
  22. ncbi Why study gene-environment interactions?
    Jose M Ordovas
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 19:158-67. 2008
    ..We examine the reasons for investigating gene-environment interactions and address recent reports evaluating interactions between genes and environmental modulators in relation to cardiovascular disease and its common risk factors...
  23. ncbi Genotype-phenotype associations: modulation by diet and obesity
    Jose M Ordovas
    Nutrition and Genetics, JM USDA HNRCA at Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:S40-6. 2008
    ..The continuous progress in nutrigenomics will allow some time in the future to provide targeted gene-based dietary advice...
  24. ncbi [Integrating environment and disease into "omic" analysis]
    Jose M Ordovas
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Rev Esp Cardiol 62:17-22. 2009
    ....
  25. ncbi Epigenetics and cardiovascular disease
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nat Rev Cardiol 7:510-9. 2010
    ..Further examination of these mechanisms may lead to earlier prevention and novel therapy for CVD...
  26. ncbi Gene-gene and gene-environment interactions defining lipid-related traits
    Jose M Ordovas
    Jean Mayer US Department of Agriculture Human Nutrition Research Centre on Aging at Tufts University, Boston, Massachusetts, USA
    Curr Opin Lipidol 22:129-36. 2011
    ..Studies over the last year have highlighted more and more polymorphisms, pathways and interactions responsible for metabolic disorders such as cardiovascular disease, obesity and dyslipidemia...
  27. ncbi Genetic variation and lipid metabolism: modulation by dietary factors
    Jose M Ordovas
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Curr Cardiol Rep 7:480-6. 2005
    ..In summary, there is need for both large population studies and well-standardized intervention studies...
  28. ncbi Genes, diet and plasma lipids: the evidence from observational studies
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    World Rev Nutr Diet 93:41-76. 2004
  29. ncbi Genetic influences on blood lipids and cardiovascular disease risk: tools for primary prevention
    Jose M Ordovas
    Nutrition and Genomics Laboratory, USDA Human Nutrition Center on Aging, Tufts University, Boston, MA, USA
    Am J Clin Nutr 89:1509S-1517S. 2009
    ....
  30. ncbi Nutritional genomics
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Annu Rev Genomics Hum Genet 5:71-118. 2004
    ....
  31. ncbi HDL genetics: candidate genes, genome wide scans and gene-environment interactions
    Jose M Ordovas
    JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Cardiovasc Drugs Ther 16:273-81. 2002
    ....
  32. ncbi Pharmacogenetics of lipid diseases
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Hum Genomics 1:111-25. 2004
    ....
  33. ncbi Postprandial triacylglycerol metabolism is modified by the presence of genetic variation at the perilipin (PLIN) locus in 2 white populations
    Pablo Perez-Martinez
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 87:744-52. 2008
    ..Several perilipin (PLIN) polymorphic sites have been studied for their potential use as markers for obesity and the metabolic syndrome...
  34. ncbi Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states
    Pablo Perez-Martinez
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 89:391-9. 2009
    ..Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR) genes has been associated with fasting plasma triacylglycerol...
  35. ncbi Age and vitamin E-induced changes in gene expression profiles of T cells
    Sung Nim Han
    Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Immunol 177:6052-61. 2006
    ..Further studies are needed to determine whether these changes are due to the effects of aging at a single-cell level or to the shift in the ratio of naïve:memory T cells with age...
  36. ncbi Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin
    Caren E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:327-32. 2010
    ..Analyses of gene-gene interactions may improve understanding of genetically based obesity risk, and underscore the need for further study of groups with multiple ancestral admixtures...
  37. ncbi Gender-specific association of a perilipin gene haplotype with obesity risk in a white population
    Lu Qi
    Nutrition and Genomics Laboratories, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Obes Res 12:1758-65. 2004
    ..Our purpose was to examine the association between common single-nucleotide polymorphisms (SNPs) at the perilipin (PLIN) locus and obesity, as well as related phenotypes, in unrelated American adults...
  38. ncbi Genetic variants at the PDZ-interacting domain of the scavenger receptor class B type I interact with diet to influence the risk of metabolic syndrome in obese men and women
    Mireia Junyent
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:842-8. 2009
    ..This gene x BMI x diet interaction offers the potential to identify dietary and other lifestyle changes that may obviate the onset of MetS in individuals with a specific genetic background...
  39. ncbi Apolipoprotein A5 polymorphisms interact with total dietary fat intake in association with markers of metabolic syndrome in Puerto Rican older adults
    Josiemer Mattei
    Jean Mayer USDA Human Nutrition Research Center on Aging, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    J Nutr 139:2301-8. 2009
    ..Dietary fat intake seems to modulate these associations. The results contribute to the understanding of health disparities in this population...
  40. ncbi APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111 1524, USA
    Arch Intern Med 169:1897-906. 2009
    ..However, replication has been low. Our aim was to study interaction among a functional APOA2 polymorphism, food intake, and body mass index (BMI) in independent populations to replicate findings and to increase their evidence level...
  41. ncbi Unique dietary patterns and chronic disease risk profiles of adult men: the Framingham nutrition studies
    Barbara E Millen
    Graduate Programs in Medical Nutrition Sciences, Boston University School of Medicine, Boston, MA, USA
    J Am Diet Assoc 105:1723-34. 2005
    ..To identify the dietary patterns of adult men and examine their relationships with nutrient intake and chronic disease risk over long-term follow-up...
  42. ncbi Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:189-97. 2008
    ..Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care...
  43. ncbi Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study
    E Shyong Tai
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
    J Nutr 135:397-403. 2005
    ..Our data show that the effect of the L162V polymorphism on plasma TG and apoC-III concentrations depends on the dietary PUFA, with a high intake triggering lower TG in carriers of the 162V allele...
  44. ncbi The L162V polymorphism at the peroxisome proliferator activated receptor alpha locus modulates the risk of cardiovascular events associated with insulin resistance and diabetes mellitus: the Veterans Affairs HDL Intervention Trial (VA-HIT)
    E Shyong Tai
    Nutrition and Genomics Unit, Jean Mayer USDA Human Nutrition Research Center for Aging at Tufts University, Boston, MA, USA
    Atherosclerosis 187:153-60. 2006
    ..We hypothesized that the association between a functional polymorphism at the PPARA locus (L162V) and the risk of a CV event, as well as response to fibrate therapy, might be greatest in those with either IR or DM (DM/IR) in VA-HIT...
  45. ncbi Population admixture associated with disease prevalence in the Boston Puerto Rican health study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Hum Genet 125:199-209. 2009
    ....
  46. ncbi WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake
    Chao Qiang Lai
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:593-600. 2009
    ..Given the high frequency of the major alleles in both populations, we suggest that WDTC1 variation may be an important risk factor contributing to obesity in these populations...
  47. ncbi Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the framingham study
    Doreen Osgood
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 88:2869-79. 2003
    ..03 for interaction). Similar results were obtained for HDL(2)-C. In conclusion, SR-BI gene variation modulates the lipid profile, particularly in type 2 diabetes, contributing to the metabolic abnormalities in these subjects...
  48. ncbi PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases: the Boston Puerto Rican Health Study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Diabetes 57:809-16. 2008
    ....
  49. ncbi Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study
    Qiong Yang
    Department of Biostatistics, Boston University, Boston, MA 02118, USA
    J Lipid Res 46:1416-25. 2005
    ..03). Further study of the linkage region and exploration of other variants in PLAGL1 are warranted to define the potential functional variants of HDL-C metabolism...
  50. ncbi Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population
    Lu Qi
    Nutrition and Genomics Laboratory, Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Mol Med (Berl) 83:448-56. 2005
    ..28 (95% CI 1.45-3.57) and Indians OR 2.04 (95% CI 1.08-3.64). These results support the role of the PLIN locus as an ethnically dependent modulator of obesity risk in humans...
  51. ncbi Informative-transmission disequilibrium test (i-TDT): combined linkage and association mapping that includes unaffected offspring as well as affected offspring
    Chao Yu Guo
    Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Genet Epidemiol 31:115-33. 2007
    ..Applying the i-TDT to the Framingham Heart Study data, we found that the apolipoprotein E (APOE) gene is significantly linked and associated with cross-sectional measures and longitudinal changes in total cholesterol...
  52. ncbi Common variants at 30 loci contribute to polygenic dyslipidemia
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:56-65. 2009
    ..These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia...
  53. ncbi Impact of genetic and environmental factors on hsCRP concentrations and response to therapeutic agents
    Jian Shen
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Clin Chem 55:256-64. 2009
    ..Both baseline hsCRP concentrations and drug-induced hsCRP changes are highly variable and potentially subject to genetic regulation...
  54. ncbi Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study
    Jian Shen
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111 1524, USA
    Diabetes Care 31:910-5. 2008
    ..We investigated the influences of CRP polymorphisms on baseline CRP levels and fenofibrate-induced CRP changes in subjects with the metabolic syndrome...
  55. ncbi Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in hispanics of Caribbean origin
    Caren E Smith
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University School of Medicine, Boston, MA 02111, USA
    J Nutr 138:1852-8. 2008
    ..These interactions may be relevant to dietary management of obesity...
  56. ncbi The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study
    Mireia Junyent
    The Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University School of Medicine, Boston, MA, USA
    J Lipid Res 50:565-73. 2009
    ..002) among smokers. In conclusion, ABCG5/G8 genetic variants modulate HDL-C concentrations, leading to an HDL-C-lowering effect and thereby a potential increased risk for atherosclerosis only in smokers...
  57. ncbi Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 90:5121-6. 2005
    ..Adipose tissue has been the focus of efforts to identify candidate genes. Perilipin is a major protein found in adipocytes, and perilipin knockout mice are lean and resistant to diet-induced obesity...
  58. ncbi APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study
    Dolores Corella
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    J Mol Med (Berl) 85:119-28. 2007
    ..In conclusion, the APOA5-1131T>C SNP, which is present in approximately 13% of this population, modulates the effect of fat intake on BMI and obesity risk in both men and women...
  59. ncbi Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study
    Roberto Elosua
    US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 47:990-6. 2006
    ..APOA5 variants were associated with CCA IMT, particularly in obese participants. The mechanism of these associations and the effect modification by obesity are independent of fasting triglyceride levels...
  60. ncbi Peroxisome proliferator-activated receptor alpha polymorphisms and postprandial lipemia in healthy men
    Toshiko Tanaka
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:1402-8. 2007
    ..These data suggest that PPARalpha variants may modulate the risk of cardiovascular disease by influencing both fasting and postprandial lipid concentrations...
  61. ncbi B vitamins and plasma homocysteine concentrations in an urban and rural area of Costa Rica
    Mi Kyung Kim
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Am Coll Nutr 22:224-31. 2003
    ..Because these characteristics are associated with high risk of cardiovascular disease, the efficacy of food fortification program in rural areas should be carefully addressed...
  62. ncbi Dietary patterns and the metabolic syndrome in obese and non-obese Framingham women
    Lillian Sonnenberg
    Ambulatory Nutrition Service, Department of Nutrition and Food Services, Massachusetts General Hospital, Boston, MA, USA
    Obes Res 13:153-62. 2005
    ....
  63. ncbi The metabolic syndrome: a crossroad for genotype-phenotype associations in atherosclerosis
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Curr Atheroscler Rep 6:186-96. 2004
    ....
  64. ncbi Matrix Gla protein polymorphisms are associated with coronary artery calcification in men
    Michael D Crosier
    USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    J Nutr Sci Vitaminol (Tokyo) 55:59-65. 2009
    ..The results of this study suggest a role for MGP genetic variants in coronary atherosclerosis among men that is not reflected in serum MGP concentrations...
  65. ncbi Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homocysteine concentrations in the Framingham Offspring Study Cohort
    Giuseppina T Russo
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:3416-21. 2003
    ..001). Our results suggest that age and sex modify the contribution of the MTHFR C677T mutation to fasting tHcy concentrations...
  66. ncbi ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, MA, USA
    J Lipid Res 45:653-6. 2004
    ..These results suggest that, in patients with hypercholesterolemia, the ABCG8 D19H variant is associated with greater LDLC-lowering response to atorvastatin therapy...
  67. ncbi Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis
    Daniel I Chasman
    Donald W Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000730. 2009
    ....
  68. ncbi Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study
    Jian Shen
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    Am J Clin Nutr 91:337-42. 2010
    ..Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects of vitamin B-6 independent of homocysteine suggest that additional mechanisms may be involved...
  69. ncbi Fatty acid interactions with genetic polymorphisms for cardiovascular disease
    Caren E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Curr Opin Clin Nutr Metab Care 13:139-44. 2010
    ..However, understanding the limitations and challenges of interaction studies, whether of observational or interventional design, is essential for critical evaluation of these studies...
  70. ncbi Uncoupling protein 2 promoter polymorphism -866G/A, central adiposity, and metabolic syndrome in Asians
    Haiqing Shen
    Nutrition and Genomics Laboratory, US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Obesity (Silver Spring) 14:656-61. 2006
    ..Our findings indicate that the uncoupling protein 2 gene -866G/A polymorphism may increase the risks of central obesity and metabolic syndrome, with greater effects on Asian men...
  71. ncbi Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study
    Roberto Elosua
    The Department of Biostatistics, Boston University, Boston, MA, United States The USDA Human Nutrition Research Center on Aging, Tufts University, MA, USA
    Atherosclerosis 189:222-8. 2006
    ..To determine the association of well-characterized lipoprotein-related genetic variants with carotid intimal medial thickness (IMT) and stenosis...
  72. ncbi ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study
    Daruneewan Warodomwichit
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:510-7. 2009
    ..Our findings support a significant association between the -11391G>A SNPs and obesity-related traits and the potential to moderate such effects using dietary modification...
  73. ncbi Gender-specific effects of estrogen receptor alpha gene haplotype on high-density lipoprotein cholesterol response to atorvastatin: interaction with apolipoprotein AI gene polymorphism
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, MA, USA
    Atherosclerosis 178:331-8. 2005
    ....
  74. ncbi The -256T>C polymorphism in the apolipoprotein A-II gene promoter is associated with body mass index and food intake in the genetics of lipid lowering drugs and diet network study
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
    Clin Chem 53:1144-52. 2007
    ..Apolipoprotein A-II (APOA2) plays an ambiguous role in lipid metabolism, obesity, and atherosclerosis...
  75. ncbi Functional genomic and epidemiological studies reveal novel genes regulating cholesterol metabolism
    Kris Richardson
    Nutrition and Genomics Laboratory, Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Genome Med 1:96. 2009
    ..Here, we review recent functional genomic research that, combined with results from genome-wide association studies, provides a powerful tool to identify novel candidate genes relevant to cholesterol metabolism...
  76. ncbi Metabolic syndrome pathophysiology: the role of adipose tissue
    Martin Laclaustra
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab Cardiovasc Dis 17:125-39. 2007
    ..Variations at multiple gene loci will be partially responsible for these interindividual differences. Two of those candidate genes, the adiponectin (APM1) and the perilipin (PLIN) genes, are discussed in more detail...
  77. ncbi Polyunsaturated fatty acids modulate the effects of the APOA1 G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the Framingham Study
    Jose M Ordovas
    Nutrition and Genomics Laboratory, the Lipid Metabolism Laboratory and the Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston 02111, USA
    Am J Clin Nutr 75:38-46. 2002
    ..The A allele was shown to be associated with higher HDL-cholesterol concentrations in some studies but not in others...
  78. ncbi MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 91:1377-86. 2010
    ..The S-adenosylmethionine synthetase type 1 (MAT1A) gene encodes a key enzyme in one-carbon nutrient metabolism...
  79. ncbi Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis
    Jimmy W Crott
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Carcinogenesis 25:69-76. 2004
    ....
  80. ncbi Fenofibrate effect on triglyceride and postprandial response of apolipoprotein A5 variants: the GOLDN study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 27:1417-25. 2007
    ..Apolipoprotein A5 (APOA5) is a key determinant of plasma triglyceride (TG) concentrations. Genetic variation at the APOA5 locus could be responsible for some of the observed differences in response to fenofibrate therapy...
  81. ncbi Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet
    Aron M Troen
    Vitamin Metabolism and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA
    Age (Dordr) 29:29-39. 2007
    ..Such defined diets can be used to identify lifespan-modifying pathways and specific gene-nutrient interactions in Drosophila...
  82. ncbi The APOA1/C3/A4/A5 gene cluster, lipid metabolism and cardiovascular disease risk
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 16:153-66. 2005
    ..In addition, we use genomic information from several species to draw inferences about the location of functional variants within this cluster...
  83. ncbi Scavenger receptor class B type I (SCARB1) c.1119C>T polymorphism affects postprandial triglyceride metabolism in men
    Toshiko Tanaka
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Nutr 137:578-82. 2007
    ..923) or total TG (Pgeno x time = 0.529) did not differ by genotype. These results suggest that the c.1119C>T polymorphism is associated with a lower postprandial TG response in the smaller, partially catabolized lipoprotein fraction...
  84. ncbi Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping
    Chao Qiang Lai
    JM USDA Human Nutrition Research Center on Aging, Nutrition and Genomics, Tufts University, Boston, MA 02111, United States
    Mech Ageing Dev 128:237-49. 2007
    ....
  85. ncbi Nutritional risk and the metabolic syndrome in women: opportunities for preventive intervention from the Framingham Nutrition Study
    Barbara E Millen
    Department of Family Medicine and the Graduate Medical Sciences Division, Boston University School of Medicine, Boston, MA, USA
    Am J Clin Nutr 84:434-41. 2006
    ..Diet is recognized as a key factor in the cause and management of the metabolic syndrome (MetS). However, policies to guide preventive clinical nutrition interventions of the condition are limited...
  86. ncbi Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study
    Mireia Junyent
    JM USDA HNRCA at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 90:686-94. 2009
    ..Of the environmental factors that determine HDL cholesterol, high-carbohydrate diets have been shown to be associated with low concentrations...
  87. ncbi Association of apo A-IV 360 (Gln --> His) polymorphism with plasma lipids and lipoproteins: the Framingham Offspring Study
    Maysa S Cendoroglo
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 179:169-75. 2005
    ..In conclusion, the apo A-IV-2 allele is associated with a modest reduction in plasma triglyceride levels in the general population...
  88. ncbi Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and women in the Framingham Offspring Study
    Ernst J Schaefer
    Lipid Research Laboratory, Division of Endocrinology, Diabetes, Metabolism, and Molecular Medicine, New England Medical Center, Boston, Massachusetts 02111, USA
    Diabetes Care 25:989-94. 2002
    ..We hypothesized that diabetic patients would have higher remnant levels than nondiabetic patients...
  89. ncbi Pharmacogenetics of Lipid-lowering Therapies
    Jose M Ordovas
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Curr Atheroscler Rep 4:183-92. 2002
    ..Future progress in this area will be driven by studying gene-gene and gene-treatment interactions in much larger patient populations...
  90. ncbi Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia
    Daruneewan Warodomwichit
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:439-46. 2009
    ..62% of energy intake) were associated with atherogenic dyslipidemia in carriers of the minor T allele at the TCF7L2 rs7903146 SNP and may predispose them to MetS, diabetes, and cardiovascular disease...
  91. ncbi Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart Study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Circulation 113:2062-70. 2006
    ..Apolipoprotein A5 gene (APOA5) variation is associated with plasma triglycerides (TGs). However, little is known about whether dietary fat modulates this association...
  92. ncbi The quest for cardiovascular health in the genomic era: nutrigenetics and plasma lipoproteins
    Jose M Ordovas
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Proc Nutr Soc 63:145-52. 2004
    ..This knowledge should lead to successful dietary recommendations partly based on genetic factors that may help to reduce cardiovascular risk more efficiently than the current universal recommendations...
  93. ncbi SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Annu Rev Nutr 25:341-90. 2005
    ..In summary, there is need for both large population studies and well-standardized intervention studies...
  94. ncbi The modulation of endothelial cell gene expression by green tea polyphenol-EGCG
    Liping Liu
    Vascular Biology Laboratory, JM USDA Human Nutrition Center on Aging at Tufts University, Boston, MA 02111, USA
    Mol Nutr Food Res 52:1182-92. 2008
    ..Our data further support earlier observations that the anticancer effect of EGCG is mediated through changes in the expression of genes that are associated with cell proliferation...
  95. ncbi Vitamin E and gene expression in immune cells
    Sung Nim Han
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:96-101. 2004
    ..Aging had significant effects on genes involved in signal transduction, transcriptional regulation, and apoptosis pathways in T cells, while vitamin E had a significant effect on genes associated with the regulation of cell cycle...
  96. ncbi Might the diabetic environment in utero lead to type 2 diabetes?
    Jose Ordovas
    Nutrition and Genomics Laboratory and Obesity and Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging at Tufts University, Boston, MA 02111, USA
    Lancet 361:1839-40. 2003
  97. ncbi Apolipoprotein C3 polymorphisms, cognitive function and diabetes in Caribbean origin Hispanics
    Caren E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States of America
    PLoS ONE 4:e5465. 2009
    ....
  98. ncbi Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study
    Caren E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111 1524, United States
    Atherosclerosis 206:500-4. 2009
    ..HDL-C response to exercise varies among individuals, and this variability may be associated with genetic polymorphisms in the key regulators of HDL metabolism including endothelial lipase (LIPG)...

Research Grants16

  1. PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTH
    Jose Ordovas; Fiscal Year: 2009
    ....
  2. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 2009
    ..This evidence-based knowledge will contribute to a rational approach toward more effective dietary recommendations aimed to decrease health disparities and to a better CVD prevention. ..
  3. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 2007
    ..This evidence-based knowledge will contribute to a rational approach toward more effective dietary recommendations aimed to decrease health disparities and to a better CVD prevention. ..
  4. PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTH
    Jose Ordovas; Fiscal Year: 2007
    ....
  5. Vitamin K: Genetics of Vascular Calcification
    Jose Ordovas; Fiscal Year: 2005
    ..This research should provide the basis for more comprehensive genetic studies aimed to provide better identification of risk and more precise therapeutic approaches for these age-related disorders. ..
  6. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 2004
    ..This knowledge will facilitate the generation of genetic screening panels that will assist in individual assessment of CHD risk and dietary therapeutic counseling. ..
  7. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 1999
    ....
  8. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose M Ordovas; Fiscal Year: 2010
    ..This evidence-based knowledge will contribute to a rational approach toward more effective dietary recommendations aimed to decrease health disparities and to a better CVD prevention. ..