J M Ordovas

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint The genetics of serum lipid responsiveness to dietary interventions
    J M Ordovas
    Lipid Metabolism Laboratory, JM USDA HNRCA, Tufts University, Boston, MA 02111, USA
    Proc Nutr Soc 58:171-87. 1999
  2. ncbi request reprint Genes, variation of cholesterol and fat intake and serum lipids
    J M Ordovas
    Lipid Metabolism Laboratory, JM USDA Human Nutrition Research Centre on Ageing, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 10:15-22. 1999
  3. ncbi request reprint Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study
    J M Ordovas
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Arterioscler Thromb Vasc Biol 20:1323-9. 2000
  4. ncbi request reprint Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in the Framingham Offspring Study
    J R Galluzzi
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 159:417-24. 2001
  5. doi request reprint ADAM17_i33708A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the Genetics of Lipid Lowering Drugs and Diet Network study
    M Junyent
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, Boston, MA 02111, USA
    Nutr Metab Cardiovasc Dis 20:698-705. 2010
  6. pmc Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance
    C E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111 1524, USA
    Nutr Metab Cardiovasc Dis 22:449-55. 2012
  7. ncbi request reprint Remnant lipoprotein cholesterol and triglyceride reference ranges from the Framingham Heart Study
    J R McNamara
    Division of Endocrinology, Diabetes, Metabolism, and Molecular Medicine, New England Medical Center, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Chem 44:1224-32. 1998
  8. ncbi request reprint Apolipoprotein E isoform polymorphisms are not associated with insulin resistance: the Framingham Offspring Study
    J B Meigs
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Diabetes Care 23:669-74. 2000
  9. pmc Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction
    D Corella
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111 1524, USA
    Int J Obes (Lond) 35:666-75. 2011
  10. doi request reprint A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study
    M Junyent
    The Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University School of Medicine, Boston, MA 02111, USA
    Nutr Metab Cardiovasc Dis 20:157-64. 2010

Detail Information

Publications62

  1. ncbi request reprint The genetics of serum lipid responsiveness to dietary interventions
    J M Ordovas
    Lipid Metabolism Laboratory, JM USDA HNRCA, Tufts University, Boston, MA 02111, USA
    Proc Nutr Soc 58:171-87. 1999
    ..Other loci, including APOA4, APOA1, APOB, APOC3, LPL and CETP have also been found to account for some of the variability in the fasting and fed states...
  2. ncbi request reprint Genes, variation of cholesterol and fat intake and serum lipids
    J M Ordovas
    Lipid Metabolism Laboratory, JM USDA Human Nutrition Research Centre on Ageing, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 10:15-22. 1999
    ..Other loci, including APOA4, APOA1 and APOB have also been found to account for some of the variability in the fasting and fed states...
  3. ncbi request reprint Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study
    J M Ordovas
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Arterioscler Thromb Vasc Biol 20:1323-9. 2000
    ..Moreover, these effects appear to translate into a lower CHD risk among those men with the B2 allele...
  4. ncbi request reprint Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in the Framingham Offspring Study
    J R Galluzzi
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 159:417-24. 2001
    ..Our data are consistent with the T54 IFABP increasing the flux of lipids through the enterocyte leading to an increase in chylomicron secretion...
  5. doi request reprint ADAM17_i33708A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the Genetics of Lipid Lowering Drugs and Diet Network study
    M Junyent
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, Boston, MA 02111, USA
    Nutr Metab Cardiovasc Dis 20:698-705. 2010
    ....
  6. pmc Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance
    C E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111 1524, USA
    Nutr Metab Cardiovasc Dis 22:449-55. 2012
    ..We aimed to investigate a previously demonstrated saturated fat and carbohydrate interaction for insulin resistance for perilipin (PLIN1), a regulator of adipocyte metabolism...
  7. ncbi request reprint Remnant lipoprotein cholesterol and triglyceride reference ranges from the Framingham Heart Study
    J R McNamara
    Division of Endocrinology, Diabetes, Metabolism, and Molecular Medicine, New England Medical Center, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Chem 44:1224-32. 1998
    ..225 mmol/L (8.7 mg/dL) and 0.346 mmol/L (30.6 mg/dL) for men. These data provide reference ranges for use in the evaluation of RLP-C and RLP-TG as potential indicators of risk for coronary heart disease...
  8. ncbi request reprint Apolipoprotein E isoform polymorphisms are not associated with insulin resistance: the Framingham Offspring Study
    J B Meigs
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Diabetes Care 23:669-74. 2000
    ..We examined the relationship between insulin resistance and apo(e) polymorphisms among participants in the Framingham Offspring Study...
  9. pmc Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction
    D Corella
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111 1524, USA
    Int J Obes (Lond) 35:666-75. 2011
    ..We have reported an APOA2-saturated fat interaction determining body mass index (BMI) and obesity in American populations. This work aims to extend our findings to European and Asian populations...
  10. doi request reprint A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study
    M Junyent
    The Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University School of Medicine, Boston, MA 02111, USA
    Nutr Metab Cardiovasc Dis 20:157-64. 2010
    ....
  11. ncbi request reprint Association of the Ala54-Thr polymorphism in the intestinal fatty acid-binding protein with 2-h postchallenge insulin levels in the Framingham Offspring Study
    J R Galluzzi
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Diabetes Care 24:1161-6. 2001
    ....
  12. ncbi request reprint Alcohol drinking determines the effect of the APOE locus on LDL-cholesterol concentrations in men: the Framingham Offspring Study
    D Corella
    Lipid Metabolism Laboratory and the Epidemiology Program, Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 73:736-45. 2001
    ..No significant associations were observed in men or women with the E3 allele. CONCLUSION: In men, the effects of alcohol intake on LDL cholesterol are modulated in part by variability at the APOE locus...
  13. pmc Apolipoprotein A-II polymorphism: relationships to behavioural and hormonal mediators of obesity
    C E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University School of Medicine, Boston, MA, USA
    Int J Obes (Lond) 36:130-6. 2012
    ..In this study, we evaluated relationships between APOA2 and obesity risk with particular focus on patterns of eating and ghrelin, a hormonal regulator of food intake...
  14. ncbi request reprint Urbanization elicits a more atherogenic lipoprotein profile in carriers of the apolipoprotein A-IV-2 allele than in A-IV-1 homozygotes
    H Campos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 17:1074-81. 1997
    ..Therefore, under the conditions studied, persons with the apoA-IV-2 allele may be more susceptible to CHD...
  15. ncbi request reprint Frequency of phenotype-genotype discrepancies at the apolipoprotein E locus in a large population study
    C Lahoz
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Clin Chem 42:1817-23. 1996
    ..Our results indicate that most discrepancies between genotype and phenotype assessment of apoE polymorphism were due to sample mishandling, data entry, and technical difficulties rather than true discordances...
  16. ncbi request reprint Remnant-like particle (RLP) cholesterol is an independent cardiovascular disease risk factor in women: results from the Framingham Heart Study
    J R McNamara
    Lipid Research Laboratory, New England Medical Center, 750 Washington Street, Box 216, Boston, MA 02111, USA
    Atherosclerosis 154:229-36. 2001
    ..002) after adjustment with other major risk factors. In conclusion, we have documented that RLP-C is an independent risk factor for CVD in women, and provides significantly more information than do triglycerides...
  17. pmc The APOA1/C3/A4/A5 cluster and markers of allostatic load in the Boston Puerto Rican Health Study
    J Mattei
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Nutr Metab Cardiovasc Dis 21:862-70. 2011
    ..We aimed to determine the association between polymorphisms in the APOA1/C3/A4/A5 cluster with allostatic load parameters, alone, and in interaction with dietary fat intake in Puerto Ricans adults...
  18. ncbi request reprint Association between the PPARA L162V polymorphism and plasma lipid levels: the Framingham Offspring Study
    E S Tai
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 22:805-10. 2002
    ..This suggests that alterations in triglyceride-rich lipoprotein metabolism may be involved in the generation of the increase in LDL cholesterol observed with the L162V PPARA polymorphism...
  19. ncbi request reprint Genetic variation at the hormone sensitive lipase: gender-specific association with plasma lipid and glucose concentrations
    L Qi
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Genet 65:93-100. 2004
    ..These SNPs were not significantly associated with anthropometrical variables. In summary, variation at this locus showed gender-specific associations with lipids and glucose measures, and the latter was influenced by alcohol drinking...
  20. ncbi request reprint Decreased production and increased catabolism of apolipoprotein B-100 in apolipoprotein B-67/B-100 heterozygotes
    F K Welty
    Jean Meyer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 17:881-8. 1997
    ..002) due primarily to a lower production rate (27% of control values). Thus, both decreased production of VLDL and LDL apoB-100 and increased catabolism of VLDL apoB-100 are responsible for the low levels of apoB-100 in apoB-67 subjects...
  21. doi request reprint The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican Health Study
    M Junyent
    The Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University School of Medicine, Boston, MA 02111, USA
    Nutr Metab Cardiovasc Dis 20:558-66. 2010
    ....
  22. ncbi request reprint Apolipoprotein E genotype affects plasma lipid response to atorvastatin in a gender specific manner
    J Pedro-Botet
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, New England Medical Center, Boston, MA, USA
    Atherosclerosis 158:183-93. 2001
    ..In summary, atorvastatin treatment had similar effects on plasma lipid levels in both men and women; however, the apoE gene locus was a significant predictor of LDL-C and TG responses to atorvastatin therapy in men, but not in women...
  23. pmc The effect of a novel intergenic polymorphism (rs11774572) on HDL-cholesterol concentrations depends on TaqIB polymorphism in the cholesterol ester transfer protein gene
    M Junyent
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab Cardiovasc Dis 20:34-40. 2010
    ....
  24. ncbi request reprint Common variants in the gene encoding ATP-binding cassette transporter 1 in men with low HDL cholesterol levels and coronary heart disease
    M E Brousseau
    The Lipid Metabolism Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts, Boston, MA, USA
    Atherosclerosis 154:607-11. 2001
    ....
  25. ncbi request reprint Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham offspring study
    G T Russo
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 158:173-81. 2001
    ..Despite the described associations with lipid and glucose metabolism related risk factors, we did not find any significant increase in CHD risk associated with the S2 allele in this population...
  26. ncbi request reprint Effects of apolipoprotein A-I genetic variations on plasma apolipoprotein, serum lipoprotein and glucose levels
    I A Larson
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Tufts University School of Medicine, New England Medical Center, Boston, MA, USA
    Clin Genet 61:176-84. 2002
    ....
  27. ncbi request reprint Frequency of ApoB and ApoE gene mutations as causes of hypobetalipoproteinemia in the framingham offspring population
    F K Welty
    Lipid Metabolism Laboratory, Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 18:1745-51. 1998
    ..21). In conclusion, a truncated apoB was a rare cause of HBLP, whereas the E2/E3 genotype was a much more common cause. A large prospective study is needed to evaluate the incidence of cancer and atherosclerosis in subjects with HBLP...
  28. ncbi request reprint Genetic determinants of plasma lipid response to dietary intervention: the role of the APOA1/C3/A4 gene cluster and the APOE gene
    J M Ordovas
    Lipid Metabolism Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Br J Nutr 83:S127-36. 2000
    ..e. APOB, CETP, LPL, FABP2, SRBI, ABC1 and CYP7)...
  29. ncbi request reprint Polymorphisms at the SRBI locus are associated with lipoprotein levels in subjects with heterozygous familial hypercholesterolemia
    E S Tai
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Genet 63:53-8. 2003
    ....
  30. ncbi request reprint Genetics, postprandial lipemia and obesity
    J M Ordovas
    Lipid Metabolism Laboratory, JM-USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab Cardiovasc Dis 11:118-33. 2001
    ..This question requires more careful research, the findings of which may contribute towards the drafting of specific dietary recommendations for the primary and secondary prevention of coronary heart disease...
  31. ncbi request reprint Gene-diet interaction and plasma lipid responses to dietary intervention
    J M Ordovas
    JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, U S A
    Biochem Soc Trans 30:68-73. 2002
    ..This knowledge will contribute towards the development of more effective personalized dietary recommendations...
  32. ncbi request reprint Human triglyceride-rich lipoprotein apo E kinetics and its relationship to LDL apo B-100 metabolism
    J S Millar
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Atherosclerosis 155:477-85. 2001
    ....
  33. ncbi request reprint Individual variability in lipoprotein cholesterol response to National Cholesterol Education Program Step 2 diets
    E J Schaefer
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 65:823-30. 1997
    ..Forty-eight percent of the variability in LDL-cholesterol response (in mmol/L) to the diet could be accounted for by baseline LDL concentrations and age in men, and 13% by age in women...
  34. ncbi request reprint Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women
    L Qi
    The Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Genet 66:299-310. 2004
    ..58, 95% confidence interval (CI): 0.38-0.93 and OR = 0.56, 95% CI: 0.36-0.89, respectively]. In summary, our data suggest that common alleles at the PLIN locus modulate body weight and metabolic variables in humans...
  35. ncbi request reprint Similarity of cruzin, an inhibitor of Trypanosoma cruzi neuraminidase, to high-density lipoprotein
    R P Prioli
    Division of Geographic Medicine and Infectious Diseases, New England Medical Center Hospitals, Inc, Boston, MA 02111
    Science 238:1417-9. 1987
    ....
  36. ncbi request reprint Gene-diet interaction and plasma lipid response to dietary intervention
    J M Ordovas
    JM USDA Human Nutrition Research Center on Aging, Tufts University School of Medicine, 711 Washington Street, Boston, MA 02111, USA
    Curr Atheroscler Rep 3:200-8. 2001
    ..It will also help to prove that knowledge of an individual's genetic background will facilitate more precise dietary counseling and intervention, and more efficacious primary and secondary coronary heart disease prevention...
  37. pmc Genetic and non-genetic correlates of vitamins K and D
    M K Shea
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Eur J Clin Nutr 63:458-64. 2009
    ..To assess the genetic and nongenetic correlates of circulating measures of vitamins K and D status in a community-based sample of men and women...
  38. ncbi request reprint Influence of photoperiod, laboratory caging and aging on plasma lipid response to an atherogenic diet among F1B hamsters
    D Smith
    Comparative Biology and Medicine, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Int J Neurosci 106:185-94. 2001
    ..005). In conclusion, photoperiod length dramatically affects diet-induced plasma lipid concentrations in young male F1B hamsters, and thus needs be considered in experimental designs of animal-housed lipid research...
  39. doi request reprint SIRT1 and CLOCK 3111T> C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity
    M Garaulet
    Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain
    Int J Obes (Lond) 36:1436-41. 2012
    ..A new negative feedback loop has been proposed, which suggests connections between the circadian clock and SIRTUIN1 (SIRT1)-dependent functions associated with cell survival, development and metabolism...
  40. ncbi request reprint Genetic polymorphisms and activity of cholesterol ester transfer protein (CETP): should we be measuring them?
    J M Ordovas
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Clin Chem Lab Med 38:945-9. 2000
    ..However, it should be noted that the evidence about the cardioprotective role of these drugs is not yet available...
  41. ncbi request reprint Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study
    C Lahoz
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Atherosclerosis 154:529-37. 2001
    ..51 (P=0.0262). Conclusions: The presence of the apo E2 or apo E4 alleles in men is associated with significantly greater CVD risk. This genotypic information may help to identify individuals at increased risk for CVD events...
  42. ncbi request reprint Estrogen increases apolipoprotein (apo) A-I secretion in hep G2 cells by modulating transcription of the apo A-I gene promoter
    S Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 19:2960-5. 1999
    ..In conclusion, E(2) increases apo A-I production in hepatic cells by increasing the transcription of the apo A-I gene...
  43. doi request reprint Polymorphism at the TRIB1 gene modulates plasma lipid levels: insight from the Spanish familial hypercholesterolemia cohort study
    A García-Rios
    Reina Sofia University Hospital, Instituto Maimonides de Investigacion Biomedica de Cordoba IMIBIC, 14004 Cordoba, University of Cordoba, CIBER Fisiopatologia de la Obesidad y Nutricion, Spain
    Nutr Metab Cardiovasc Dis 21:957-63. 2011
    ....
  44. ncbi request reprint Familial apolipoprotein A-I, C-III, and A-IV deficiency and premature atherosclerosis due to deletion of a gene complex on chromosome 11
    J M Ordovas
    United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111
    J Biol Chem 264:16339-42. 1989
    ..The data support the concept of an independent role for HDL in the pathogenesis of atherosclerosis...
  45. ncbi request reprint Gene-diet interactions and plasma lipoproteins: role of apolipoprotein E and habitual saturated fat intake
    H Campos
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genet Epidemiol 20:117-128. 2001
    ..05 mmol/L, P = 0.009). These data suggest that the APOE2 allele could modulate the effect of habitual saturated fat on VLDL cholesterol and HDL cholesterol in a population with an average habitual total fat intake of less than 30%...
  46. ncbi request reprint Hearts and bones
    L Qi
    Nutrition and Genomics Laboratory, JM USDA HNRCA, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab Cardiovasc Dis 13:165-74. 2003
    ....
  47. ncbi request reprint Novel mutations in the gene encoding ATP-binding cassette 1 in four tangier disease kindreds
    M E Brousseau
    Lipid Metabolism Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University and Department of Medicine, New England Medical Center, Boston, MA 02111, USA
    J Lipid Res 41:433-41. 2000
    ..These results establish a causal role for mutations in hABC-1 in TD and indicate that this transporter has a critical function in the regulation of intracellular lipid trafficking that dramatically affects plasma HDL cholesterol levels...
  48. pmc Familial apolipoprotein E deficiency
    E J Schaefer
    J Clin Invest 78:1206-19. 1986
    ....
  49. ncbi request reprint The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss
    M J Shin
    Yonsei Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea
    Int J Obes (Lond) 30:1702-8. 2006
    ..Subjects:In total, 294 nondiabetic/overweight-obese Koreans participated in a clinical intervention study lasting 12 weeks involving a caloric reduction of -300kcal/day...
  50. ncbi request reprint The significant increase in cardiovascular disease risk in APOEepsilon4 carriers is evident only in men who smoke: potential relationship between reduced antioxidant status and ApoE4
    P J Talmud
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, Rayne Building, University College London, 5 University St, London WC1E 6JF, United Kingdom
    Ann Hum Genet 69:613-22. 2005
    ....
  51. ncbi request reprint Environmental factors modulate the effect of the APOE genetic polymorphism on plasma lipid concentrations: ecogenetic studies in a Mediterranean Spanish population
    D Corella
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine and Public Health, Universitat de Valencia, Valencia, Spain
    Metabolism 50:936-44. 2001
    ..Our results indicate that environmental factors are important modulators of the effect of the APOE polymorphism on plasma lipid concentrations...
  52. ncbi request reprint Genetic polymorphisms and lipid response to dietary changes in humans
    R M Weggemans
    Division of Human Nutrition and Epidemiology, Centre for Food Sciences, Wageningen University, Bomenweg 2, 6073 HD Wageningen, The Netherlands
    Eur J Clin Invest 31:950-7. 2001
    ..Therefore, knowledge of these genotypes by themselves is of little use in the identification of subjects who may or may not benefit from dietary treatment...
  53. ncbi request reprint Interaction between smoking and the Sstl polymorphism of the apo C-III gene determines plasma lipid response to diet
    P Perez-Martinez
    Unidad de Lipidos y Arteriosclerosis, Hospital Universitario Reina Sofia, Cordoba, Spain
    Nutr Metab Cardiovasc Dis 11:237-43. 2001
    ..It has recently been demonstrated that the lipid profile of smokers improves if they follow a Mediterranean diet...
  54. ncbi request reprint Apoprotein E genotype and the response of serum cholesterol to dietary fat, cholesterol and cafestol
    R M Weggemans
    Division of Human Nutrition and Epidemiology, Wageningen University, Bomenweg 2, 6703 HD, Wageningen, The Netherlands
    Atherosclerosis 154:547-55. 2001
    ..However, the effects are small. Therefore, knowledge of the APOE genotype by itself may be of little use in the identification of subjects who respond to diet...
  55. ncbi request reprint Effects of apolipoprotein A-IV genotype on glucose and plasma lipoprotein levels
    I A Larson
    Department of Internal Medicine, University Heidelberg School of Medicine, Heidelberg, Germany
    Clin Genet 61:430-6. 2002
    ..However, apo A-IV 360 1/2 genotype did have a significant effect on serum glucose levels in women...
  56. ncbi request reprint ATP binding cassette G5 C1950G polymorphism may affect blood cholesterol concentrations in humans
    R M Weggemans
    Unilever Health Institute, Unilever Research and Development Vlaardingen, The Netherlands
    Clin Genet 62:226-9. 2002
    ..Studies in other populations and experimental settings are required to confirm or reject this hypothesis...
  57. ncbi request reprint The TaqIB and -629C>A polymorphisms at the cholesteryl ester transfer protein locus: associations with lipid levels in a multiethnic population. The 1998 Singapore National Health Survey
    E S Tai
    Department of Endocrinology, Singapore General Hospital, Singapore
    Clin Genet 63:19-30. 2003
    ..Moreover, we observed an ethnic-specific interaction among dietary cholesterol, the TaqIB polymorphism and HDL-C concentrations...
  58. ncbi request reprint APOE polymorphism and lipid profile in three ethnic groups in the Singapore population
    C E Tan
    Department of Endocrinology, Singapore General Hospital, Block 6 level 6, Outram Road, Singapore 169608, Singapore
    Atherosclerosis 170:253-60. 2003
    ..Having three major ethnic groups within a similar social environment allows us to study the role of genetics and their interactions with lifestyle factors on the serum lipid profile and coronary risk in Asians...
  59. ncbi request reprint The lipoprotein lipase S447X polymorphism and plasma lipids: interactions with APOE polymorphisms, smoking, and alcohol consumption
    J Lee
    National University of Singapore Genome Institute of Singapore Center for Molecular Epidemiology, Community, Occupational and Family Medicine, Singapore
    J Lipid Res 45:1132-9. 2004
    ..Interactions with APOE genotype, cigarette smoking, and alcohol intake reinforce the importance of examining genetic associations, such as this one, in the context of the population of interest...
  60. ncbi request reprint The "game of life": getting to know the players and their tactics
    J M Ordovas
    Nutr Metab Cardiovasc Dis 12:313-5. 2002
  61. ncbi request reprint Large rearrangements of the LDL receptor gene and lipid profile in a FH Spanish population
    F J Chaves
    , Valencia, Spain
    Eur J Clin Invest 31:309-17. 2001
    ....
  62. ncbi request reprint Linkage, evolution, and expression of the rat apolipoprotein A-I, C-III, and A-IV genes
    I A Haddad
    J Biol Chem 261:13268-77. 1986
    ..In addition, these results indicate that expression of the rat apoA-I, apoC-III, and apoA-IV genes is liver- and intestine-specific and regulated by fetal-, neonatal-, and aging-related factors...