Research Topics
| Paul E MilburySummaryAffiliation: Tufts University Country: USA Publications
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Publications
Flavonoid intake and eye healthPaul E Milbury
Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts 02111, USA
J Nutr Gerontol Geriatr 31:254-68. 2012..Support for clinical trials remains to be found before a full "recommendation" can be made regarding the value of diets high in flavonoids for eye health...
Determination of flavonoids and phenolics and their distribution in almondsPaul E Milbury
Antioxidants Research Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
J Agric Food Chem 54:5027-33. 2006....- Anthocyanins are bioavailable in humans following an acute dose of cranberry juicePaul E Milbury
Gerald J and Dorothy R Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
J Nutr 140:1099-104. 2010..Observed concentrations of plasma anthocyanins appear insufficient to alter radical load or redox potential but may be adequate to affect signal transduction and/or gene expression... - Xenobiotic metabolism and berry flavonoid transport across the blood-brain barrierPaul E Milbury
Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
J Agric Food Chem 58:3950-6. 2010..The plausible mechanism of neuroprotective action of anthocyanins may be via modulation of signal transduction processes and/or gene expression in brain tissue rather than by direct antioxidant radical quenching... - Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cellsPaul E Milbury
Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
Invest Ophthalmol Vis Sci 48:2343-9. 2007.... - Flavonoids from almond skins are bioavailable and act synergistically with vitamins C and E to enhance hamster and human LDL resistance to oxidationChung-Yen Chen
Antioxidants Research Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University
J Nutr 135:1366-73. 2005..5% (P < or = 0.05). Thus, ASF possess antioxidant capacity in vitro; they are bioavailable and act in synergy with vitamins C and E to protect LDL against oxidation in hamsters... - Effect of almond skin polyphenolics and quercetin on human LDL and apolipoprotein B-100 oxidation and conformationChung Yen Chen
Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr Biochem 18:785-94. 2007..Thus, ASP and quercetin reduce the oxidative modification of apo B-100 and stabilize LDL conformation in a dose-dependent manner, acting in an additive or synergistic fashion with VC and VE... - Avenanthramides and phenolic acids from oats are bioavailable and act synergistically with vitamin C to enhance hamster and human LDL resistance to oxidationChung-Yen Chen
Antioxidants Research Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
J Nutr 134:1459-66. 2004..005). Thus, oat phenolics, including avenanthramides, are bioavailable in hamsters and interact synergistically with vitamin C to protect LDL during oxidation... - Avenanthramides are bioavailable and have antioxidant activity in humans after acute consumption of an enriched mixture from oatsC Y Oliver Chen
Antioxidants Research Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr 137:1375-82. 2007..After consumption of 1 g AEM, plasma reduced glutathione was elevated by 21% at 15 min (P < or = 0.005) and by 14% at 10 h (P < or = 0.05). Thus, oat AV are bioavailable and increase antioxidant capacity in healthy older adults... - Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted ratsClement K Ameho
Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr Biochem 19:467-74. 2008..However, vitamin E status appears to enhance the distribution of isorhamnetin into the circulation and its disposition in muscle... 
Effects of cranberry juice consumption on vascular function in patients with coronary artery diseaseMustali M Dohadwala
Evans Department of Medicine and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
Am J Clin Nutr 93:934-40. 2011..Cranberry juice contains polyphenolic compounds that could improve endothelial function and reduce cardiovascular disease risk...- Rat gastrointestinal tissues metabolize quercetinBrigitte A Graf
Antioxidants Research Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA
J Nutr 136:39-44. 2006..The unique pattern of quercetin metabolites in each GI tissue indicates extensive biotransformation before absorption and distribution in rats... - Antioxidant status and biomarkers of oxidative stress in dogs with congestive heart failureLisa M Freeman
Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA
J Vet Intern Med 19:537-41. 2005..The effect of dietary interventions to correct this imbalance in antioxidant defenses warrants further study... - Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelaeJason DeFuria
Obesity and Metabolism Laboratory and 5Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 139:1510-6. 2009..These results suggest that cytoprotective and antiinflammatory actions of dietary BB can provide metabolic benefits to combat obesity-associated pathology... - Flavonols, flavones, flavanones, and human health: epidemiological evidenceBrigitte A Graf
Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
J Med Food 8:281-90. 2005..As the totality of the available evidence on these flavonoids suggests a role in the prevention of cancer and cardiovascular disease, further research is warranted, particularly in controlled clinical trials... - The effect of dietary glutathione and coenzyme Q10 on the prevention and treatment of inflammatory bowel disease in miceChun Liu
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
Int J Vitam Nutr Res 74:74-85. 2004..Further studies using additional animal models are required to determine whether GSH or CoQ10 provide a favorable or unfavorable benefit:risk ratio in the prevention or treatment of IBD... - Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly menJennifer M Sacheck
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Tufts University, Boston, MA 02111, USA
Free Radic Biol Med 34:1575-88. 2003.... - Bioavailablility of elderberry anthocyaninsPaul E Milbury
Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Room 507, 711 Washington St Boston, MA 02111, USA
Mech Ageing Dev 123:997-1006. 2002..The current findings appear to refute assumptions that anthocyanins are not absorbed in their unchanged glycosylated forms in humans... - Characterization of diet-dependent metabolic serotypes: primary validation of male and female serotypes in independent cohorts of ratsHonglian Shi
Dementia Research Service, Burke Medical Research Institute, White Plains, NY 10605, USA
J Nutr 132:1039-46. 2002.... - Moderate antioxidant supplementation has no effect on biomarkers of oxidant damage in healthy men with low fruit and vegetable intakesRobert A Jacob
U S Department of Agriculture ARS Western Human Nutrition Research Center, University of California at Davis, 95616 8683, USA
J Nutr 133:740-3. 2003..In healthy young men, the endogenous antioxidant defense system and a modest intake of dietary antioxidants are adequate to minimize levels of in vivo oxidant damage such that they cannot be differentiated by current methods... - Characterization of diet-dependent metabolic serotypes: proof of principle in female and male ratsHonglian Shi
Dementia Research Service, Burke Medical Research Institute, White Plains, NY 10605, USA
J Nutr 132:1031-8. 2002.... - Dietary iron promotes azoxymethane-induced colon tumors in miceJillian N M Ilsley
Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
Nutr Cancer 49:162-9. 2004..Our results suggest that, following carcinogen exposure, elevated dietary iron promotes the growth of tumors with altered cellular homeostasis through a mechanism that is independent of oxidative stress... - Development of biomarkers based on diet-dependent metabolic serotypes: practical issues in development of expert system-based classification models in metabolomic studiesHonglian Shi
Dementia Research Service, Burke Medical Research Institute, White Plains, New York, USA
OMICS 8:197-208. 2004.... - Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigsWilhelmina Kalt
Atlantic Food and Horticulture Research Center, Agriculture and Agri Food Canada, 32 Main Street, Kentville, Nova Scotia, Canada B4N 1J5
J Agric Food Chem 56:705-12. 2008..The results suggest that anthocyanins can accumulate in tissues, including tissues beyond the blood-brain barrier...