Paul E Milbury

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Bioavailablility of elderberry anthocyanins
    Paul E Milbury
    Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Room 507, 711 Washington St Boston, MA 02111, USA
    Mech Ageing Dev 123:997-1006. 2002
  2. ncbi request reprint Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats
    Clement K Ameho
    Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 19:467-74. 2008
  3. ncbi request reprint Avenanthramides and phenolic acids from oats are bioavailable and act synergistically with vitamin C to enhance hamster and human LDL resistance to oxidation
    Chung Yen Chen
    Antioxidants Research Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Nutr 134:1459-66. 2004
  4. ncbi request reprint Antioxidant status and biomarkers of oxidative stress in dogs with congestive heart failure
    Lisa M Freeman
    Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA
    J Vet Intern Med 19:537-41. 2005
  5. ncbi request reprint Determination of flavonoids and phenolics and their distribution in almonds
    Paul E Milbury
    Antioxidants Research Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Agric Food Chem 54:5027-33. 2006
  6. ncbi request reprint The effect of dietary glutathione and coenzyme Q10 on the prevention and treatment of inflammatory bowel disease in mice
    Chun Liu
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Int J Vitam Nutr Res 74:74-85. 2004
  7. ncbi request reprint Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men
    Jennifer M Sacheck
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 34:1575-88. 2003
  8. doi request reprint Xenobiotic metabolism and berry flavonoid transport across the blood-brain barrier
    Paul E Milbury
    Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Agric Food Chem 58:3950-6. 2010
  9. ncbi request reprint Avenanthramides are bioavailable and have antioxidant activity in humans after acute consumption of an enriched mixture from oats
    C Y Oliver Chen
    Antioxidants Research Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 137:1375-82. 2007
  10. doi request reprint Anthocyanins are bioavailable in humans following an acute dose of cranberry juice
    Paul E Milbury
    Gerald J and Dorothy R Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    J Nutr 140:1099-104. 2010

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Bioavailablility of elderberry anthocyanins
    Paul E Milbury
    Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Room 507, 711 Washington St Boston, MA 02111, USA
    Mech Ageing Dev 123:997-1006. 2002
    ..The current findings appear to refute assumptions that anthocyanins are not absorbed in their unchanged glycosylated forms in humans...
  2. ncbi request reprint Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats
    Clement K Ameho
    Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 19:467-74. 2008
    ..However, vitamin E status appears to enhance the distribution of isorhamnetin into the circulation and its disposition in muscle...
  3. ncbi request reprint Avenanthramides and phenolic acids from oats are bioavailable and act synergistically with vitamin C to enhance hamster and human LDL resistance to oxidation
    Chung Yen Chen
    Antioxidants Research Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Nutr 134:1459-66. 2004
    ..005). Thus, oat phenolics, including avenanthramides, are bioavailable in hamsters and interact synergistically with vitamin C to protect LDL during oxidation...
  4. ncbi request reprint Antioxidant status and biomarkers of oxidative stress in dogs with congestive heart failure
    Lisa M Freeman
    Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA
    J Vet Intern Med 19:537-41. 2005
    ..The effect of dietary interventions to correct this imbalance in antioxidant defenses warrants further study...
  5. ncbi request reprint Determination of flavonoids and phenolics and their distribution in almonds
    Paul E Milbury
    Antioxidants Research Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Agric Food Chem 54:5027-33. 2006
    ....
  6. ncbi request reprint The effect of dietary glutathione and coenzyme Q10 on the prevention and treatment of inflammatory bowel disease in mice
    Chun Liu
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Int J Vitam Nutr Res 74:74-85. 2004
    ..Further studies using additional animal models are required to determine whether GSH or CoQ10 provide a favorable or unfavorable benefit:risk ratio in the prevention or treatment of IBD...
  7. ncbi request reprint Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men
    Jennifer M Sacheck
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 34:1575-88. 2003
    ....
  8. doi request reprint Xenobiotic metabolism and berry flavonoid transport across the blood-brain barrier
    Paul E Milbury
    Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Agric Food Chem 58:3950-6. 2010
    ..The plausible mechanism of neuroprotective action of anthocyanins may be via modulation of signal transduction processes and/or gene expression in brain tissue rather than by direct antioxidant radical quenching...
  9. ncbi request reprint Avenanthramides are bioavailable and have antioxidant activity in humans after acute consumption of an enriched mixture from oats
    C Y Oliver Chen
    Antioxidants Research Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 137:1375-82. 2007
    ..After consumption of 1 g AEM, plasma reduced glutathione was elevated by 21% at 15 min (P < or = 0.005) and by 14% at 10 h (P < or = 0.05). Thus, oat AV are bioavailable and increase antioxidant capacity in healthy older adults...
  10. doi request reprint Anthocyanins are bioavailable in humans following an acute dose of cranberry juice
    Paul E Milbury
    Gerald J and Dorothy R Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    J Nutr 140:1099-104. 2010
    ..Observed concentrations of plasma anthocyanins appear insufficient to alter radical load or redox potential but may be adequate to affect signal transduction and/or gene expression...
  11. pmc Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae
    Jason DeFuria
    Obesity and Metabolism Laboratory and 5Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:1510-6. 2009
    ..These results suggest that cytoprotective and antiinflammatory actions of dietary BB can provide metabolic benefits to combat obesity-associated pathology...
  12. ncbi request reprint Effect of almond skin polyphenolics and quercetin on human LDL and apolipoprotein B-100 oxidation and conformation
    Chung Yen Chen
    Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 18:785-94. 2007
    ..Thus, ASP and quercetin reduce the oxidative modification of apo B-100 and stabilize LDL conformation in a dose-dependent manner, acting in an additive or synergistic fashion with VC and VE...
  13. ncbi request reprint Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells
    Paul E Milbury
    Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 48:2343-9. 2007
    ....
  14. ncbi request reprint Flavonols, flavones, flavanones, and human health: epidemiological evidence
    Brigitte A Graf
    Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Med Food 8:281-90. 2005
    ..As the totality of the available evidence on these flavonoids suggests a role in the prevention of cancer and cardiovascular disease, further research is warranted, particularly in controlled clinical trials...
  15. ncbi request reprint Flavonoids from almond skins are bioavailable and act synergistically with vitamins C and E to enhance hamster and human LDL resistance to oxidation
    Chung Yen Chen
    Antioxidants Research Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University
    J Nutr 135:1366-73. 2005
    ..5% (P < or = 0.05). Thus, ASF possess antioxidant capacity in vitro; they are bioavailable and act in synergy with vitamins C and E to protect LDL against oxidation in hamsters...
  16. ncbi request reprint Development of biomarkers based on diet-dependent metabolic serotypes: practical issues in development of expert system-based classification models in metabolomic studies
    Honglian Shi
    Dementia Research Service, Burke Medical Research Institute, White Plains, New York, USA
    OMICS 8:197-208. 2004
    ....
  17. ncbi request reprint Dietary iron promotes azoxymethane-induced colon tumors in mice
    Jillian N M Ilsley
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Nutr Cancer 49:162-9. 2004
    ..Our results suggest that, following carcinogen exposure, elevated dietary iron promotes the growth of tumors with altered cellular homeostasis through a mechanism that is independent of oxidative stress...
  18. ncbi request reprint Moderate antioxidant supplementation has no effect on biomarkers of oxidant damage in healthy men with low fruit and vegetable intakes
    Robert A Jacob
    U S Department of Agriculture ARS Western Human Nutrition Research Center, University of California at Davis, 95616 8683, USA
    J Nutr 133:740-3. 2003
    ..In healthy young men, the endogenous antioxidant defense system and a modest intake of dietary antioxidants are adequate to minimize levels of in vivo oxidant damage such that they cannot be differentiated by current methods...
  19. ncbi request reprint Characterization of diet-dependent metabolic serotypes: primary validation of male and female serotypes in independent cohorts of rats
    Honglian Shi
    Dementia Research Service, Burke Medical Research Institute, White Plains, NY 10605, USA
    J Nutr 132:1039-46. 2002
    ....
  20. ncbi request reprint Characterization of diet-dependent metabolic serotypes: proof of principle in female and male rats
    Honglian Shi
    Dementia Research Service, Burke Medical Research Institute, White Plains, NY 10605, USA
    J Nutr 132:1031-8. 2002
    ....
  21. ncbi request reprint Rat gastrointestinal tissues metabolize quercetin
    Brigitte A Graf
    Antioxidants Research Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA
    J Nutr 136:39-44. 2006
    ..The unique pattern of quercetin metabolites in each GI tissue indicates extensive biotransformation before absorption and distribution in rats...
  22. doi request reprint Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs
    Wilhelmina Kalt
    Atlantic Food and Horticulture Research Center, Agriculture and Agri Food Canada, 32 Main Street, Kentville, Nova Scotia, Canada B4N 1J5
    J Agric Food Chem 56:705-12. 2008
    ..The results suggest that anthocyanins can accumulate in tissues, including tissues beyond the blood-brain barrier...