Research Topics
| KLAUS MICZEKSummaryAffiliation: Tufts University Country: USA Publications
Research Grants
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Detail Information
Publications
Social defeat stress, sensitization, and intravenous cocaine self-administration in miceJasmine J Yap
Department of Psychology, Tufts University, Medford, MA 02155, USA
Psychopharmacology (Berl) 192:261-73. 2007..Behavioral sensitization has been proposed as a process that is important in compulsive drug use and in psychotic disorders...
Excessive aggression as model of violence: a critical evaluation of current preclinical methodsKlaus A Miczek
Department of Psychology, Tufts University, Bacon Hall, 530 Boston Ave, Medford, MA 02155, USA
Psychopharmacology (Berl) 226:445-58. 2013..Preclinical experimental models of pathological aggressive behavior are a sorely understudied and difficult research area...- Aggression and defeat: persistent effects on cocaine self-administration and gene expression in peptidergic and aminergic mesocorticolimbic circuitsKlaus A Miczek
Department of Psychology, Tufts University, Bacon Hall, 530 Boston Avenue, Medford, MA 02155, USA
Neurosci Biobehav Rev 27:787-802. 2004..Social stress alters the feedback from prefrontal cortex and thereby may contribute to the dysregulation of dopaminergic activity that is necessary for cocaine self-administration... - Escalated aggressive behavior: new pharmacotherapeutic approaches and opportunitiesKlaus A Miczek
Departments of Psychology, Tufts University, Medford, Massachusetts 02155, USA
Ann N Y Acad Sci 1036:336-55. 2004..The modulation of GABA and GABA(A) receptors by 5-HT in corticolimbic neurons promises to be particularly relevant for specific forms of escalated aggressive behavior such as alcohol-heightened aggression... - Neurobiology of escalated aggression and violenceKlaus A Miczek
Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
J Neurosci 27:11803-6. 2007.... - Neurosteroids, GABAA receptors, and escalated aggressive behaviorKlaus A Miczek
Department of Psychology, Tufts University, Medford and Boston, MA 02155, USA
Horm Behav 44:242-57. 2003..Initial studies targeting alpha subunits of the GABAA receptor point to their significant role in the aggression-heightening effects of alcohol, benzodiazepines, and neurosteroids... 
Challenges for translational psychopharmacology research--some basic principlesKlaus A Miczek
Tufts University, 530 Boston Avenue Bacon Hall, Medford, MA 02155, USA
Psychopharmacology (Berl) 199:291-301. 2008..8. Psychological processes pertinent to affect and cognition can only be studied in preclinical models if they are defined in behavioral and neural terms...- Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intakeKlaus A Miczek
Departments of Psychology, Psychiatry, Pharmacology and Neuroscience, Tufts University, Medford and Boston, MA 02155, United States
Pharmacol Ther 120:102-28. 2008.... - Escalated or suppressed cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic versus continuous social stress in ratsKlaus A Miczek
Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
J Neurosci 31:9848-57. 2011..These divergent neuroadaptations to social stress may represent the substrates for the intensification of cocaine "bingeing" relative to the anhedonia-like deterioration of reward processes during subordination stress... - Role of alcohol consumption in escalation to violenceKlaus A Miczek
Departments of Psychology, Tufts University, Medford, Massachusetts 02155, USA
Ann N Y Acad Sci 1036:278-89. 2004..How these GABAergic and serotonergic corticolimbic mechanisms for alcohol-heightened aggression develop during the adolescent period remains an area of urgent study... - Gene expression in aminergic and peptidergic cells during aggression and defeat: relevance to violence, depression and drug abuseKlaus A Miczek
Department of Psychology, Tufts University, 530 Boston Ave Bacon Hall, Medford, MA 02155, USA
Behav Genet 41:787-802. 2011..intermittent exposure to social stress, suggesting divergent neuroadaptations for increased vulnerability to cocaine self-administration vs. deteriorated reward mechanisms characteristic of depressive-like profiles... - Increased accumbal dopamine during daily alcohol consumption and subsequent aggressive behavior in ratsAnnemoon M M van Erp
Department of Psychology, Bacon Hall, Tufts University, 530 Boston Avenue, Medford, MA 02155, USA
Psychopharmacology (Berl) 191:679-88. 2007..Assessing the dynamic changes in these neurotransmitters during the course of drinking and fighting has remained challenging... - Brief social defeat stress: long lasting effects on cocaine taking during a binge and zif268 mRNA expression in the amygdala and prefrontal cortexHerbert E Covington
Department of Psychology, Tufts University, Medford, MA 02155, USA
Neuropsychopharmacology 30:310-21. 2005..Divergent changes in zif268 within the amygdala and cortex 2 months after social defeat stress indicate the vulnerability of distinct cellular populations in networks that modulate the behavioral actions of psychomotor stimulants... - Aggression escalated by social instigation or by discontinuation of reinforcement ("frustration") in mice: inhibition by anpirtoline: a 5-HT1B receptor agonistRosa M M de Almeida
Departments of Psychology, Tufts University, Bacon Hall, 530 Boston Avenue, Medford, MA 02155, USA
Neuropsychopharmacology 27:171-81. 2002..The aggression-inhibiting effects of anpirtoline were blocked by pretreatment with GR127935. The current results indicate that the 5-HT(1B) receptor is critically involved in the modulation of escalated aggression... - NMDA receptors in the rat VTA: a critical site for social stress to intensify cocaine takingHerbert E Covington
Department of Psychology, Tufts University, Medford and Boston, MA, USA
Psychopharmacology (Berl) 197:203-16. 2008..Cocaine strengthens behaviors associated with its administration. The stress response by individuals that are defeated in a brief aggressive confrontation can also promote enduring behavioral consequences similar to those of stimulants... - Escalated aggression after alcohol drinking in male mice: dorsal raphé and prefrontal cortex serotonin and 5-HT(1B) receptorsSara Faccidomo
Department of Psychology, Tufts University, Medford, MA, USA
Neuropsychopharmacology 33:2888-99. 2008..This 5-HT increase was attenuated in self-administering mice. These results suggest that 5-HT(1B) receptors in the mPFC may serve to selectively disinhibit aggressive behavior in mice with a history of Alc self-administration... - Repeated alcohol: behavioral sensitization and alcohol-heightened aggression in miceEric W Fish
Department of Psychology, Tufts University, 530 Boston Ave, Medford, MA 02155, USA
Psychopharmacology (Berl) 160:39-48. 2002..Moreover, the results suggest that at least some of the neuroadaptations caused by repeated administration of alcohol are relevant to alcohol-heightened aggression... - Intense cocaine self-administration after episodic social defeat stress, but not after aggressive behavior: dissociation from corticosterone activationHerbert E Covington
Department of Psychology, Tufts University, 530 Boston Ave Bacon Hall, Medford, MA 02155, USA
Psychopharmacology (Berl) 183:331-40. 2005..An intense stress response characterizes both the dominant and submissive individuals during an aggressive confrontation, and these stress responses have enduring neural and behavioral consequences... - GABAA/alpha1 receptor agonists and antagonists: effects on species-typical and heightened aggressive behavior after alcohol self-administration in miceRosa M M de Almeida
Department of Psychology, Tufts University, Bacon Hall, 530 Boston Avenue, Medford, MA 02155, USA
Psychopharmacology (Berl) 172:255-63. 2004.... - Repeated maternal separation: differences in cocaine-induced behavioral sensitization in adult male and female miceTakefumi Kikusui
Department of Psychology, Tufts University, Medford, MA 02155, USA
Psychopharmacology (Berl) 178:202-10. 2005..Furthermore, sex differences in glucocorticoid receptor and dopamine transporter expression may be responsible for the sexual dimorphic expression of behavioral sensitization to cocaine... - Aggressive behavior as a reinforcer in mice: activation by allopregnanoloneEric W Fish
Department of Psychology, Tufts University, 530 Boston Ave (Bacon Hall, Medford, MA 02155, USA
Psychopharmacology (Berl) 163:459-66. 2002.... - Repeated brief social defeat episodes in mice: effects on cell proliferation in the dentate gyrusJasmine J Yap
Department of Psychology, Tufts University, 530 Boston Avenue, Bacon Hall, Medford, MA 02155, USA
Behav Brain Res 172:344-50. 2006.... - GABA(A) receptors in the dorsal raphé nucleus of mice: escalation of aggression after alcohol consumptionAki Takahashi
Department of Psychology, Tufts University, Bacon Hall, 530 Boston Ave, Medford, MA 02155, USA
Psychopharmacology (Berl) 211:467-77. 2010..Gamma aminobutyric acid type-A (GABA(A)) and type-B (GABA(B)) receptors are expressed in the DRN and modulate 5-HT neuronal activity, and both play a role in the behavioral effect of alcohol... - Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at serotonin, dopamine and gamma-aminobutyric acid systemsKlaus A Miczek
Department of Psychology, Tufts University, Medford, MA 02155, USA
Psychopharmacology (Berl) 163:434-58. 2002..Obstacles at the level of social policy, institutional regulation, and scientific strategy in developing animal models continue to impede the development of specific anti-aggressive agents for emergency and long-term treatments... - Social rank and social separation as determinants of alcohol drinking in squirrel monkeysSara D McKenzie-Quirk
Department of Psychology, Tufts University, Medford, MA 02155, USA
Psychopharmacology (Berl) 201:137-45. 2008..Social stress is particularly relevant to alcohol drinking, and a primate model of stress-induced alcohol self-administration would be useful... - Prolonged effects of repeated social defeat stress on mRNA expression and function of mu-opioid receptors in the ventral tegmental area of ratsElla M Nikulina
Department of Psychiatry, Tufts University, Boston, MA, USA
Neuropsychopharmacology 30:1096-103. 2005..This locomotor effect is probably the consequence of enhanced disinhibition of mesolimbic dopamine neurons... - 5-HT(1B) receptor inhibition of alcohol-heightened aggression in mice: comparison to drinking and runningEric W Fish
Department of Psychology, Tufts University, 530 Boston Ave Bacon Hall, Medford, MA, USA
Psychopharmacology (Berl) 197:145-56. 2008..Serotonin 5-HT(1B) receptors are promising targets for the management of several mood and impulse disorders... - 5-HT1A agonists: alcohol drinking in rats and squirrel monkeysSara D McKenzie-Quirk
Department of Psychology, Tufts University, 530 Boston Avenue (Bacon Hall, Medford, MA 02155, USA
Psychopharmacology (Berl) 167:145-52. 2003..The absence of such biphasic dose-effect curves in monkeys suggests a different function of 5-HT(1A) somatodendritic receptors in rats and monkeys, at least with regard to alcohol drinking... - Two modes of intense cocaine bingeing: increased persistence after social defeat stress and increased rate of intake due to extended access conditions in ratsIsabel M H Quadros
Department of Psychology, Tufts University, 530 Boston Ave Bacon Hall, Medford, MA 02155, USA
Psychopharmacology (Berl) 206:109-20. 2009..Escalated, binge-like patterns of cocaine self-administration are engendered by repeated, intermittent exposure to episodes of social defeat stress, as well as by extended drug access... - Behavioral sensitization due to social defeat stress in mice: antagonism at mGluR5 and NMDA receptorsJasmine J Yap
Department of Psychology, Tufts University, Medford, Mass, USA
Psychopharmacology (Berl) 179:230-9. 2005..CONCLUSIONS: These data indicate that behavioral sensitization to social defeat stress is dependent on mGluR5 receptors, whereas low-dose amphetamine sensitization may not be... - Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pupsAki Takahashi
Department of Psychology, Tufts University, Medford, MA 02155, USA
Psychopharmacology (Berl) 204:61-71. 2009..The roles of glutamate receptors on USVs remain to be investigated... - Benzodiazepines and heightened aggressive behavior in rats: reduction by GABA(A)/alpha(1) receptor antagonistsShannon L Gourley
Department of Psychology, Tufts University, 530 Boston Ave. (Bacon Hall, Medford, MA 02155, USA
Psychopharmacology (Berl) 178:232-40. 2005..0 mg/kg) and 3-PBC (0.3-17.0 mg/kg) also antagonized the aggression-heightening effects of midazolam (1.0 mg/kg).CONCLUSIONS: These results implicate both the GABA(A) gamma and alpha(1) subunits in benzodiazepine-heightened aggression... - Long-term citalopram maintenance in mice: selective reduction of alcohol-heightened aggressionElizabeth E Caldwell
Department of Psychology, Tufts University, Medford, MA 02155, USA
Psychopharmacology (Berl) 196:407-16. 2008..Selective serotonin reuptake inhibitors (SSRIs) alleviate many affective disturbances in human clinical populations and are used in animal models to study the influence of serotonin (5-HT) on aggressive behavior and impulsivity... - Anti-aggressive effects of agonists at 5-HT1B receptors in the dorsal raphe nucleus of miceMakoto Bannai
Department of Psychology, Tufts University, Medford and Boston, MA, USA
Psychopharmacology (Berl) 193:295-304. 2007..Responses preceding the opportunity to attack may reflect aggressive motivation... - Escalated aggression as a reward: corticosterone and GABA(A) receptor positive modulators in miceEric W Fish
Department of Psychology, Tufts University, Medford, MA, USA
Psychopharmacology (Berl) 182:116-27. 2005..Individuals seek out the opportunity to fight, but the mechanisms behind this positively reinforcing effect of aggression have yet to be understood... - GABA(B) receptor modulation of serotonin neurons in the dorsal raphé nucleus and escalation of aggression in miceAki Takahashi
Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
J Neurosci 30:11771-80. 2010..These findings suggest that the indirect disinhibition of 5-HT neuron activity by presynaptic GABA(B) receptors on non-5-HT neurons in the DRN is one of the neurobiological mechanisms of escalated aggression... - Anxiolytic-like effects of escitalopram, citalopram, and R-citalopram in maternally separated mouse pupsEric W Fish
Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
J Pharmacol Exp Ther 308:474-80. 2004..These data support clinical findings that escitalopram is a potent, well tolerated SSRI with anxiolytic-like effects... - Vocalizations during withdrawal from opiates and cocaine: possible expressions of affective distressHerbert E Covington
Department of Psychology, Tufts University, Medford, MA 02155, USA
Eur J Pharmacol 467:1-13. 2003..It will be informative to learn how the neural circuit mediating vocalizations interacts with the ones subserving self-administration of alcohol, opiates and psychomotor stimulants... - Escalated aggressive behavior: dopamine, serotonin and GABARosa M M de Almeida
, Psicologia e Biologia, UNISINOS, , RS, Brazil
Eur J Pharmacol 526:51-64. 2005..A prerequisite for rational pharmacotherapies will be adequate characterization of serotonergic and GABAergic receptor regulation in individuals exhibiting escalated aggression... - Heightened aggression after chronic flunitrazepam in male rats: potential links to cortical and caudate-putamen-binding sitesRosa Maria M de Almeida
Laboratorio de Neurociencias, Centro 2, UNISINOS, Av Unisinos, 950, 93022 000 São Leopoldo, RS, Brazil
Psychopharmacology (Berl) 197:309-18. 2008..The determinants for increasing aggression after chronic intake of flunitrazepam, a so-called date rape drug, in violence-prone individuals are incompletely understood... - Stereotyped and complex motor routines expressed during cocaine self-administration: results from a 24-h binge of unlimited cocaine access in ratsStephen C Fowler
Department of Pharmacology and Toxicology, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045 2505, USA
Psychopharmacology (Berl) 192:465-78. 2007.... - Serotonin and aggressive behavior in rodents and nonhuman primates: predispositions and plasticityPier Francesco Ferrari
Dipartimento di Neuroscienze, Universita di Parma, Via Volturno 39, 43100 Parma, Italy
Eur J Pharmacol 526:259-73. 2005.... - Youth violence. Scientific approaches to prevention. PrologueJohn Devine
Ann N Y Acad Sci 1036:ix-xii. 2004 - Long-lasting alteration in mesocorticolimbic structures after repeated social defeat stress in rats: time course of mu-opioid receptor mRNA and FosB/DeltaFosB immunoreactivityElla M Nikulina
Department of Basic Medical Sciences, University of Arizona, College of Medicine Phoenix, 425 N Fifth Street, ABC 1, Phoenix, AZ 85004 2157, USA
Eur J Neurosci 27:2272-84. 2008.... - Effects of corticotropin-releasing hormone on distress vocalizations and locomotion in maternally separated mouse pupsAnneloes Dirks
Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
Pharmacol Biochem Behav 72:993-9. 2002..The present study indicates that in mouse pups, the effects of CRH administration depend on baseline levels of arousal and that the behavioral effects of CRH administration can be dissociated under mild and more stressful conditions...
Research Grants
- Behavioral Neurobiology of AggressionKLAUS MICZEK; Fiscal Year: 2007..abstract_text> ..
- Behavioral Neurobiology of Aggression: Alcohol, GABA, and 5-HTKlaus A Miczek; Fiscal Year: 2010....
- Behavioral Neurobiology of Aggression: Alcohol, GABA, and 5-HTKlaus A Miczek; Fiscal Year: 2010....
- PSYCHOMOTOR STIMULANTS AND AGGRESSIONKLAUS MICZEK; Fiscal Year: 2003....
- ALCOHOL BENZODIAZEPHINES AND AGGRESSION IN ANIMALSKLAUS MICZEK; Fiscal Year: 2002....
- PSYCHOMOTOR STIMULANTS AND AGGRESSION IN ANIMALSKLAUS MICZEK; Fiscal Year: 2007..Reversal of cross-sensitization from stress may be a means by which to prevent the transition to out-of-control compulsive-like drug taking. ..
- PSYCHOMOTOR STIMULANTS AND AGGRESSIONKLAUS MICZEK; Fiscal Year: 1993..Protocols are designed to investigate the release of dopamine and its metabolites during social stress or i.v. cocaine self-administration or both, and to investigate potentially protective treatments...
- PSYCHOMOTOR STIMULANTS AND AGGRESSION IN ANIMALSKLAUS MICZEK; Fiscal Year: 1980..Further experiments are designed to investigate the effects of psychomotor stimulants on aggressive behavior in female animals. The interaction of drug effects with the hormonal condition of the females will be studied. ..
- PSYCHOMOTOR STIMULANTS & AGGRESSION IN ANIMALSKLAUS MICZEK; Fiscal Year: 1992..A final set of experiments will attempt to antagonize amphetamine and cocaine effects on social and aggressive behavior with prazosin and other drugs that interfere with noradrenergic and dopaminergic neurotransmission...