Genomes and Genes




Affiliation: Tufts University
Country: USA


  1. Arena D, Covington H, DeBold J, Miczek K. Persistent increase of I.V. cocaine self-administration in a subgroup of C57BL/6J male mice after social defeat stress. Psychopharmacology (Berl). 2019;: pubmed publisher
  2. Miczek K, Nikulina E, Takahashi A, Covington H, Yap J, Boyson C, et al. Gene expression in aminergic and peptidergic cells during aggression and defeat: relevance to violence, depression and drug abuse. Behav Genet. 2011;41:787-802 pubmed publisher
    ..intermittent exposure to social stress, suggesting divergent neuroadaptations for increased vulnerability to cocaine self-administration vs. deteriorated reward mechanisms characteristic of depressive-like profiles. ..
  3. Newman E, Albrechet Souza L, Andrew P, Auld J, Burk K, Hwa L, et al. Persistent escalation of alcohol consumption by mice exposed to brief episodes of social defeat stress: suppression by CRF-R1 antagonism. Psychopharmacology (Berl). 2018;235:1807-1820 pubmed publisher
    ..Future studies will clarify how social defeat stress may alter the expression of extrahypothalamic CRF-R1 and glucocorticoid receptors. ..
  4. Miczek K, de Wit H. Challenges for translational psychopharmacology research--some basic principles. Psychopharmacology (Berl). 2008;199:291-301 pubmed publisher
    ..8. Psychological processes pertinent to affect and cognition can only be studied in preclinical models if they are defined in behavioral and neural terms. ..
  5. Miczek K, de Boer S, Haller J. Excessive aggression as model of violence: a critical evaluation of current preclinical methods. Psychopharmacology (Berl). 2013;226:445-58 pubmed publisher
    ..Identifying novel targets for effective intervention requires increased understanding of the distinctive molecular, cellular, and circuit mechanisms for each type of abnormal aggressive behavior. ..
  6. Hwa L, Holly E, DeBold J, Miczek K. Social stress-escalated intermittent alcohol drinking: modulation by CRF-R1 in the ventral tegmental area and accumbal dopamine in mice. Psychopharmacology (Berl). 2016;233:681-90 pubmed publisher
    ..CRF-R1 may be a mechanism for balancing the dysregulation of stress and reward in alcohol use disorders. ..
  7. Miczek K, Nikulina E, Shimamoto A, Covington H. Escalated or suppressed cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic versus continuous social stress in rats. J Neurosci. 2011;31:9848-57 pubmed publisher
    ..These divergent neuroadaptations to social stress may represent the substrates for the intensification of cocaine "bingeing" relative to the anhedonia-like deterioration of reward processes during subordination stress. ..
  8. Burke A, DeBold J, Miczek K. CRF type 1 receptor antagonism in ventral tegmental area of adolescent rats during social defeat: prevention of escalated cocaine self-administration in adulthood and behavioral adaptations during adolescence. Psychopharmacology (Berl). 2016;233:2727-36 pubmed publisher
    ..CP376395 treatment in adolescence blocked escalation of cocaine taking in adulthood. Episodes of social defeat stress engender neuroadaptation in CRF-R1s in the VTA that alter coping with social stress and that persist into adulthood. ..
  9. Boyson C, Holly E, Burke A, Montagud Romero S, DeBold J, Miczek K. Maladaptive choices by defeated rats: link between rapid approach to social threat and escalated cocaine self-administration. Psychopharmacology (Berl). 2016;233:3173-86 pubmed publisher
    ..These data suggest that latency to enter a threatening environment is a novel behavioral characteristic predictive of later cocaine self-administration. ..

More Information


  1. Han X, DeBold J, Miczek K. Prevention and reversal of social stress-escalated cocaine self-administration in mice by intra-VTA CRFR1 antagonism. Psychopharmacology (Berl). 2017;234:2813-2821 pubmed publisher
    ..These findings suggest that CRF and CRFR1 exert multiple roles in the response to social stress that are relevant to escalated cocaine self-administration. ..
  2. Leonard M, DeBold J, Miczek K. Escalated cocaine "binges" in rats: enduring effects of social defeat stress or intra-VTA CRF. Psychopharmacology (Berl). 2017;234:2823-2836 pubmed publisher
    ..Conversely, the persistent pattern of cocaine bingeing induced by social defeat stress may suggest impaired inhibitory control, independent of reward valuation. ..