KLAUS MICZEK

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Social defeat stress, sensitization, and intravenous cocaine self-administration in mice
    Jasmine J Yap
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Psychopharmacology (Berl) 192:261-73. 2007
  2. pmc Excessive aggression as model of violence: a critical evaluation of current preclinical methods
    Klaus A Miczek
    Department of Psychology, Tufts University, Bacon Hall, 530 Boston Ave, Medford, MA 02155, USA
    Psychopharmacology (Berl) 226:445-58. 2013
  3. ncbi request reprint Aggression and defeat: persistent effects on cocaine self-administration and gene expression in peptidergic and aminergic mesocorticolimbic circuits
    Klaus A Miczek
    Department of Psychology, Tufts University, Bacon Hall, 530 Boston Avenue, Medford, MA 02155, USA
    Neurosci Biobehav Rev 27:787-802. 2004
  4. ncbi request reprint Escalated aggressive behavior: new pharmacotherapeutic approaches and opportunities
    Klaus A Miczek
    Departments of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    Ann N Y Acad Sci 1036:336-55. 2004
  5. pmc Neurobiology of escalated aggression and violence
    Klaus A Miczek
    Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    J Neurosci 27:11803-6. 2007
  6. ncbi request reprint Neurosteroids, GABAA receptors, and escalated aggressive behavior
    Klaus A Miczek
    Department of Psychology, Tufts University, Medford and Boston, MA 02155, USA
    Horm Behav 44:242-57. 2003
  7. doi request reprint Challenges for translational psychopharmacology research--some basic principles
    Klaus A Miczek
    Tufts University, 530 Boston Avenue Bacon Hall, Medford, MA 02155, USA
    Psychopharmacology (Berl) 199:291-301. 2008
  8. pmc Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intake
    Klaus A Miczek
    Departments of Psychology, Psychiatry, Pharmacology and Neuroscience, Tufts University, Medford and Boston, MA 02155, United States
    Pharmacol Ther 120:102-28. 2008
  9. pmc Escalated or suppressed cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic versus continuous social stress in rats
    Klaus A Miczek
    Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    J Neurosci 31:9848-57. 2011
  10. ncbi request reprint Role of alcohol consumption in escalation to violence
    Klaus A Miczek
    Departments of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    Ann N Y Acad Sci 1036:278-89. 2004

Research Grants

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Social defeat stress, sensitization, and intravenous cocaine self-administration in mice
    Jasmine J Yap
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Psychopharmacology (Berl) 192:261-73. 2007
    ..Behavioral sensitization has been proposed as a process that is important in compulsive drug use and in psychotic disorders...
  2. pmc Excessive aggression as model of violence: a critical evaluation of current preclinical methods
    Klaus A Miczek
    Department of Psychology, Tufts University, Bacon Hall, 530 Boston Ave, Medford, MA 02155, USA
    Psychopharmacology (Berl) 226:445-58. 2013
    ..Preclinical experimental models of pathological aggressive behavior are a sorely understudied and difficult research area...
  3. ncbi request reprint Aggression and defeat: persistent effects on cocaine self-administration and gene expression in peptidergic and aminergic mesocorticolimbic circuits
    Klaus A Miczek
    Department of Psychology, Tufts University, Bacon Hall, 530 Boston Avenue, Medford, MA 02155, USA
    Neurosci Biobehav Rev 27:787-802. 2004
    ..Social stress alters the feedback from prefrontal cortex and thereby may contribute to the dysregulation of dopaminergic activity that is necessary for cocaine self-administration...
  4. ncbi request reprint Escalated aggressive behavior: new pharmacotherapeutic approaches and opportunities
    Klaus A Miczek
    Departments of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    Ann N Y Acad Sci 1036:336-55. 2004
    ..The modulation of GABA and GABA(A) receptors by 5-HT in corticolimbic neurons promises to be particularly relevant for specific forms of escalated aggressive behavior such as alcohol-heightened aggression...
  5. pmc Neurobiology of escalated aggression and violence
    Klaus A Miczek
    Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    J Neurosci 27:11803-6. 2007
    ....
  6. ncbi request reprint Neurosteroids, GABAA receptors, and escalated aggressive behavior
    Klaus A Miczek
    Department of Psychology, Tufts University, Medford and Boston, MA 02155, USA
    Horm Behav 44:242-57. 2003
    ..Initial studies targeting alpha subunits of the GABAA receptor point to their significant role in the aggression-heightening effects of alcohol, benzodiazepines, and neurosteroids...
  7. doi request reprint Challenges for translational psychopharmacology research--some basic principles
    Klaus A Miczek
    Tufts University, 530 Boston Avenue Bacon Hall, Medford, MA 02155, USA
    Psychopharmacology (Berl) 199:291-301. 2008
    ..8. Psychological processes pertinent to affect and cognition can only be studied in preclinical models if they are defined in behavioral and neural terms...
  8. pmc Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intake
    Klaus A Miczek
    Departments of Psychology, Psychiatry, Pharmacology and Neuroscience, Tufts University, Medford and Boston, MA 02155, United States
    Pharmacol Ther 120:102-28. 2008
    ....
  9. pmc Escalated or suppressed cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic versus continuous social stress in rats
    Klaus A Miczek
    Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    J Neurosci 31:9848-57. 2011
    ..These divergent neuroadaptations to social stress may represent the substrates for the intensification of cocaine "bingeing" relative to the anhedonia-like deterioration of reward processes during subordination stress...
  10. ncbi request reprint Role of alcohol consumption in escalation to violence
    Klaus A Miczek
    Departments of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    Ann N Y Acad Sci 1036:278-89. 2004
    ..How these GABAergic and serotonergic corticolimbic mechanisms for alcohol-heightened aggression develop during the adolescent period remains an area of urgent study...
  11. pmc Gene expression in aminergic and peptidergic cells during aggression and defeat: relevance to violence, depression and drug abuse
    Klaus A Miczek
    Department of Psychology, Tufts University, 530 Boston Ave Bacon Hall, Medford, MA 02155, USA
    Behav Genet 41:787-802. 2011
    ..intermittent exposure to social stress, suggesting divergent neuroadaptations for increased vulnerability to cocaine self-administration vs. deteriorated reward mechanisms characteristic of depressive-like profiles...
  12. ncbi request reprint Increased accumbal dopamine during daily alcohol consumption and subsequent aggressive behavior in rats
    Annemoon M M van Erp
    Department of Psychology, Bacon Hall, Tufts University, 530 Boston Avenue, Medford, MA 02155, USA
    Psychopharmacology (Berl) 191:679-88. 2007
    ..Assessing the dynamic changes in these neurotransmitters during the course of drinking and fighting has remained challenging...
  13. ncbi request reprint Brief social defeat stress: long lasting effects on cocaine taking during a binge and zif268 mRNA expression in the amygdala and prefrontal cortex
    Herbert E Covington
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Neuropsychopharmacology 30:310-21. 2005
    ..Divergent changes in zif268 within the amygdala and cortex 2 months after social defeat stress indicate the vulnerability of distinct cellular populations in networks that modulate the behavioral actions of psychomotor stimulants...
  14. ncbi request reprint Aggression escalated by social instigation or by discontinuation of reinforcement ("frustration") in mice: inhibition by anpirtoline: a 5-HT1B receptor agonist
    Rosa M M de Almeida
    Departments of Psychology, Tufts University, Bacon Hall, 530 Boston Avenue, Medford, MA 02155, USA
    Neuropsychopharmacology 27:171-81. 2002
    ..The aggression-inhibiting effects of anpirtoline were blocked by pretreatment with GR127935. The current results indicate that the 5-HT(1B) receptor is critically involved in the modulation of escalated aggression...
  15. pmc NMDA receptors in the rat VTA: a critical site for social stress to intensify cocaine taking
    Herbert E Covington
    Department of Psychology, Tufts University, Medford and Boston, MA, USA
    Psychopharmacology (Berl) 197:203-16. 2008
    ..Cocaine strengthens behaviors associated with its administration. The stress response by individuals that are defeated in a brief aggressive confrontation can also promote enduring behavioral consequences similar to those of stimulants...
  16. doi request reprint Escalated aggression after alcohol drinking in male mice: dorsal raphé and prefrontal cortex serotonin and 5-HT(1B) receptors
    Sara Faccidomo
    Department of Psychology, Tufts University, Medford, MA, USA
    Neuropsychopharmacology 33:2888-99. 2008
    ..This 5-HT increase was attenuated in self-administering mice. These results suggest that 5-HT(1B) receptors in the mPFC may serve to selectively disinhibit aggressive behavior in mice with a history of Alc self-administration...
  17. ncbi request reprint Repeated alcohol: behavioral sensitization and alcohol-heightened aggression in mice
    Eric W Fish
    Department of Psychology, Tufts University, 530 Boston Ave, Medford, MA 02155, USA
    Psychopharmacology (Berl) 160:39-48. 2002
    ..Repeated administration of alcohol can also induce behavioral sensitization and may have consequences on how alcohol affects aggressive behavior...
  18. ncbi request reprint Intense cocaine self-administration after episodic social defeat stress, but not after aggressive behavior: dissociation from corticosterone activation
    Herbert E Covington
    Department of Psychology, Tufts University, 530 Boston Ave Bacon Hall, Medford, MA 02155, USA
    Psychopharmacology (Berl) 183:331-40. 2005
    ..An intense stress response characterizes both the dominant and submissive individuals during an aggressive confrontation, and these stress responses have enduring neural and behavioral consequences...
  19. ncbi request reprint GABAA/alpha1 receptor agonists and antagonists: effects on species-typical and heightened aggressive behavior after alcohol self-administration in mice
    Rosa M M de Almeida
    Department of Psychology, Tufts University, Bacon Hall, 530 Boston Avenue, Medford, MA 02155, USA
    Psychopharmacology (Berl) 172:255-63. 2004
    ..However, the degree to which GABAA subunit composition plays a role in heightened aggressive behavior induced by self-administration of a moderate alcohol dose remains unresolved...
  20. ncbi request reprint Repeated maternal separation: differences in cocaine-induced behavioral sensitization in adult male and female mice
    Takefumi Kikusui
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Psychopharmacology (Berl) 178:202-10. 2005
    ..These neural changes are postulated to influence the vulnerability to drugs of abuse implicating glucocortocoids in the behavioral responses to psychomotor stimulants...
  21. ncbi request reprint Aggressive behavior as a reinforcer in mice: activation by allopregnanolone
    Eric W Fish
    Department of Psychology, Tufts University, 530 Boston Ave Bacon Hall, Medford, MA 02155, USA
    Psychopharmacology (Berl) 163:459-66. 2002
    ..The neurobiological mechanisms that underlie the motivation to engage in an aggressive confrontation remain to be investigated...
  22. ncbi request reprint Repeated brief social defeat episodes in mice: effects on cell proliferation in the dentate gyrus
    Jasmine J Yap
    Department of Psychology, Tufts University, 530 Boston Avenue, Bacon Hall, Medford, MA 02155, USA
    Behav Brain Res 172:344-50. 2006
    ....
  23. pmc GABA(A) receptors in the dorsal raphé nucleus of mice: escalation of aggression after alcohol consumption
    Aki Takahashi
    Department of Psychology, Tufts University, Bacon Hall, 530 Boston Ave, Medford, MA 02155, USA
    Psychopharmacology (Berl) 211:467-77. 2010
    ..Gamma aminobutyric acid type-A (GABA(A)) and type-B (GABA(B)) receptors are expressed in the DRN and modulate 5-HT neuronal activity, and both play a role in the behavioral effect of alcohol...
  24. ncbi request reprint Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at serotonin, dopamine and gamma-aminobutyric acid systems
    Klaus A Miczek
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Psychopharmacology (Berl) 163:434-58. 2002
    ..Obstacles at the level of social policy, institutional regulation, and scientific strategy in developing animal models continue to impede the development of specific anti-aggressive agents for emergency and long-term treatments...
  25. doi request reprint Social rank and social separation as determinants of alcohol drinking in squirrel monkeys
    Sara D McKenzie-Quirk
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Psychopharmacology (Berl) 201:137-45. 2008
    ..Social stress is particularly relevant to alcohol drinking, and a primate model of stress-induced alcohol self-administration would be useful...
  26. ncbi request reprint Prolonged effects of repeated social defeat stress on mRNA expression and function of mu-opioid receptors in the ventral tegmental area of rats
    Ella M Nikulina
    Department of Psychiatry, Tufts University, Boston, MA, USA
    Neuropsychopharmacology 30:1096-103. 2005
    ..This locomotor effect is probably the consequence of enhanced disinhibition of mesolimbic dopamine neurons...
  27. ncbi request reprint 5-HT(1B) receptor inhibition of alcohol-heightened aggression in mice: comparison to drinking and running
    Eric W Fish
    Department of Psychology, Tufts University, 530 Boston Ave Bacon Hall, Medford, MA, USA
    Psychopharmacology (Berl) 197:145-56. 2008
    ..Serotonin 5-HT(1B) receptors are promising targets for the management of several mood and impulse disorders...
  28. ncbi request reprint 5-HT1A agonists: alcohol drinking in rats and squirrel monkeys
    Sara D McKenzie-Quirk
    Department of Psychology, Tufts University, 530 Boston Avenue Bacon Hall, Medford, MA 02155, USA
    Psychopharmacology (Berl) 167:145-52. 2003
    ....
  29. doi request reprint Two modes of intense cocaine bingeing: increased persistence after social defeat stress and increased rate of intake due to extended access conditions in rats
    Isabel M H Quadros
    Department of Psychology, Tufts University, 530 Boston Ave Bacon Hall, Medford, MA 02155, USA
    Psychopharmacology (Berl) 206:109-20. 2009
    ..Escalated, binge-like patterns of cocaine self-administration are engendered by repeated, intermittent exposure to episodes of social defeat stress, as well as by extended drug access...
  30. ncbi request reprint Behavioral sensitization due to social defeat stress in mice: antagonism at mGluR5 and NMDA receptors
    Jasmine J Yap
    Department of Psychology, Tufts University, Medford, Mass, USA
    Psychopharmacology (Berl) 179:230-9. 2005
    ..Both metabotropic and ionotropic glutamate receptors have been shown to be critical in the induction and expression of stimulant sensitization, but their role in sensitization due to social defeat stress remains unclear...
  31. pmc Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups
    Aki Takahashi
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Psychopharmacology (Berl) 204:61-71. 2009
    ..The roles of glutamate receptors on USVs remain to be investigated...
  32. ncbi request reprint Benzodiazepines and heightened aggressive behavior in rats: reduction by GABA(A)/alpha(1) receptor antagonists
    Shannon L Gourley
    Department of Psychology, Tufts University, 530 Boston Ave Bacon Hall, Medford, MA 02155, USA
    Psychopharmacology (Berl) 178:232-40. 2005
    ..Positive modulators of the benzodiazepine/GABA(A) receptor complex can heighten aggressive behavior; the GABA(A)/alpha(1) subunit may play a critical role in benzodiazepine-modulated aggressive behavior...
  33. ncbi request reprint Long-term citalopram maintenance in mice: selective reduction of alcohol-heightened aggression
    Elizabeth E Caldwell
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Psychopharmacology (Berl) 196:407-16. 2008
    ..Selective serotonin reuptake inhibitors (SSRIs) alleviate many affective disturbances in human clinical populations and are used in animal models to study the influence of serotonin (5-HT) on aggressive behavior and impulsivity...
  34. ncbi request reprint Anti-aggressive effects of agonists at 5-HT1B receptors in the dorsal raphe nucleus of mice
    Makoto Bannai
    Department of Psychology, Tufts University, Medford and Boston, MA, USA
    Psychopharmacology (Berl) 193:295-304. 2007
    ..Responses preceding the opportunity to attack may reflect aggressive motivation...
  35. ncbi request reprint Escalated aggression as a reward: corticosterone and GABA(A) receptor positive modulators in mice
    Eric W Fish
    Department of Psychology, Tufts University, Medford, MA, USA
    Psychopharmacology (Berl) 182:116-27. 2005
    ..Individuals seek out the opportunity to fight, but the mechanisms behind this positively reinforcing effect of aggression have yet to be understood...
  36. pmc GABA(B) receptor modulation of serotonin neurons in the dorsal raphé nucleus and escalation of aggression in mice
    Aki Takahashi
    Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    J Neurosci 30:11771-80. 2010
    ..These findings suggest that the indirect disinhibition of 5-HT neuron activity by presynaptic GABA(B) receptors on non-5-HT neurons in the DRN is one of the neurobiological mechanisms of escalated aggression...
  37. ncbi request reprint Anxiolytic-like effects of escitalopram, citalopram, and R-citalopram in maternally separated mouse pups
    Eric W Fish
    Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    J Pharmacol Exp Ther 308:474-80. 2004
    ..These data support clinical findings that escitalopram is a potent, well tolerated SSRI with anxiolytic-like effects...
  38. ncbi request reprint Vocalizations during withdrawal from opiates and cocaine: possible expressions of affective distress
    Herbert E Covington
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Eur J Pharmacol 467:1-13. 2003
    ..It will be informative to learn how the neural circuit mediating vocalizations interacts with the ones subserving self-administration of alcohol, opiates and psychomotor stimulants...
  39. ncbi request reprint Escalated aggressive behavior: dopamine, serotonin and GABA
    Rosa M M de Almeida
    Laboratorio de Neurociencias, Psicologia e Biologia, UNISINOS, Sao Leopoldo, RS, Brazil
    Eur J Pharmacol 526:51-64. 2005
    ..A prerequisite for rational pharmacotherapies will be adequate characterization of serotonergic and GABAergic receptor regulation in individuals exhibiting escalated aggression...
  40. ncbi request reprint Heightened aggression after chronic flunitrazepam in male rats: potential links to cortical and caudate-putamen-binding sites
    Rosa Maria M de Almeida
    Laboratorio de Neurociencias, Centro 2, UNISINOS, Av Unisinos, 950, 93022 000 São Leopoldo, RS, Brazil
    Psychopharmacology (Berl) 197:309-18. 2008
    ..The determinants for increasing aggression after chronic intake of flunitrazepam, a so-called date rape drug, in violence-prone individuals are incompletely understood...
  41. ncbi request reprint Stereotyped and complex motor routines expressed during cocaine self-administration: results from a 24-h binge of unlimited cocaine access in rats
    Stephen C Fowler
    Department of Pharmacology and Toxicology, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045 2505, USA
    Psychopharmacology (Berl) 192:465-78. 2007
    ....
  42. ncbi request reprint Serotonin and aggressive behavior in rodents and nonhuman primates: predispositions and plasticity
    Pier Francesco Ferrari
    Dipartimento di Neuroscienze, Universita di Parma, Via Volturno 39, 43100 Parma, Italy
    Eur J Pharmacol 526:259-73. 2005
    ....
  43. ncbi request reprint Youth violence. Scientific approaches to prevention. Prologue
    John Devine
    Ann N Y Acad Sci 1036:ix-xii. 2004
  44. pmc Long-lasting alteration in mesocorticolimbic structures after repeated social defeat stress in rats: time course of mu-opioid receptor mRNA and FosB/DeltaFosB immunoreactivity
    Ella M Nikulina
    Department of Basic Medical Sciences, University of Arizona, College of Medicine Phoenix, 425 N Fifth Street, ABC 1, Phoenix, AZ 85004 2157, USA
    Eur J Neurosci 27:2272-84. 2008
    ....
  45. ncbi request reprint Effects of corticotropin-releasing hormone on distress vocalizations and locomotion in maternally separated mouse pups
    Anneloes Dirks
    Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
    Pharmacol Biochem Behav 72:993-9. 2002
    ..The present study indicates that in mouse pups, the effects of CRH administration depend on baseline levels of arousal and that the behavioral effects of CRH administration can be dissociated under mild and more stressful conditions...

Research Grants41

  1. Behavioral Neurobiology of Aggression
    KLAUS MICZEK; Fiscal Year: 2007
    ..abstract_text> ..
  2. Behavioral Neurobiology of Aggression: Alcohol, GABA, and 5-HT
    Klaus A Miczek; Fiscal Year: 2010
    ....
  3. Behavioral Neurobiology of Aggression: Alcohol, GABA, and 5-HT
    Klaus A Miczek; Fiscal Year: 2010
    ....
  4. PSYCHOMOTOR STIMULANTS AND AGGRESSION
    KLAUS MICZEK; Fiscal Year: 2003
    ....
  5. ALCOHOL BENZODIAZEPHINES AND AGGRESSION IN ANIMALS
    KLAUS MICZEK; Fiscal Year: 2002
    ....
  6. PSYCHOMOTOR STIMULANTS AND AGGRESSION IN ANIMALS
    KLAUS MICZEK; Fiscal Year: 2007
    ..Reversal of cross-sensitization from stress may be a means by which to prevent the transition to out-of-control compulsive-like drug taking. ..
  7. PSYCHOMOTOR STIMULANTS AND AGGRESSION
    KLAUS MICZEK; Fiscal Year: 1993
    ..Protocols are designed to investigate the release of dopamine and its metabolites during social stress or i.v. cocaine self-administration or both, and to investigate potentially protective treatments...
  8. PSYCHOMOTOR STIMULANTS AND AGGRESSION IN ANIMALS
    KLAUS MICZEK; Fiscal Year: 1980
    ..Further experiments are designed to investigate the effects of psychomotor stimulants on aggressive behavior in female animals. The interaction of drug effects with the hormonal condition of the females will be studied. ..
  9. PSYCHOMOTOR STIMULANTS & AGGRESSION IN ANIMALS
    KLAUS MICZEK; Fiscal Year: 1992
    ..A final set of experiments will attempt to antagonize amphetamine and cocaine effects on social and aggressive behavior with prazosin and other drugs that interfere with noradrenergic and dopaminergic neurotransmission...