Simin N Meydani

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Vitamin E and immune response in the aged: molecular mechanisms and clinical implications
    Simin Nikbin Meydani
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Immunol Rev 205:269-84. 2005
  2. pmc Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit
    Junpeng Wang
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab (Lond) 10:29. 2013
  3. ncbi request reprint Vitamin E and respiratory infection in the elderly
    Simin Nikbin Meydani
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:214-22. 2004
  4. doi request reprint Nutrition and age-associated inflammation: implications for disease prevention
    Simin Nikbin Meydani
    JMUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    JPEN J Parenter Enteral Nutr 32:626-9. 2008
  5. pmc Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial
    Simin Nikbin Meydani
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Mass 02111, USA
    JAMA 292:828-36. 2004
  6. ncbi request reprint Vitamin E supplementation reverses the age-associated decrease in effective immune synapse formation in CD4+ T cells
    Tanvir Ahmed
    Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:412-4. 2004
  7. ncbi request reprint Age-associated inflammatory changes: role of nutritional intervention
    Simin Nikbin Meydani
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University Boston, Massachussetts 02111, USA
    Nutr Rev 65:S213-6. 2007
  8. pmc Serum zinc and pneumonia in nursing home elderly
    Simin N Meydani
    Nutritional Immunology Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 86:1167-73. 2007
  9. doi request reprint Epigallocatechin-3-gallate directly suppresses T cell proliferation through impaired IL-2 utilization and cell cycle progression
    Munkyong Pae
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 140:1509-15. 2010
  10. ncbi request reprint Effect of hydrogenated and saturated, relative to polyunsaturated, fat on immune and inflammatory responses of adults with moderate hypercholesterolemia
    Sung Nim Han
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Lipid Res 43:445-52. 2002

Research Grants

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Vitamin E and immune response in the aged: molecular mechanisms and clinical implications
    Simin Nikbin Meydani
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Immunol Rev 205:269-84. 2005
    ..Further studies are needed to determine the signaling mechanisms involved in the upregulation of naive T-cell function by vitamin E as well as the specific mechanisms involved in reduction of risk for upper respiratory infections...
  2. pmc Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit
    Junpeng Wang
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab (Lond) 10:29. 2013
    ..This study sought to determine if curcumin could potentiate CR's beneficial effect on immune and inflammatory responses in obesity developed in mice by feeding high-fat diet (HFD)...
  3. ncbi request reprint Vitamin E and respiratory infection in the elderly
    Simin Nikbin Meydani
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:214-22. 2004
    ....
  4. doi request reprint Nutrition and age-associated inflammation: implications for disease prevention
    Simin Nikbin Meydani
    JMUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    JPEN J Parenter Enteral Nutr 32:626-9. 2008
    ..Nutrient/dietary medications, such as antioxidants and certain lipids have suggested a promising route to reduce the age-related increase in COX activity and PGE(2) production that is associated with several disease states...
  5. pmc Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial
    Simin Nikbin Meydani
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Mass 02111, USA
    JAMA 292:828-36. 2004
    ..Vitamin E supplementation has been shown to improve immune response in elderly persons. However, the clinical importance of these findings has not been determined...
  6. ncbi request reprint Vitamin E supplementation reverses the age-associated decrease in effective immune synapse formation in CD4+ T cells
    Tanvir Ahmed
    Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:412-4. 2004
    ..Further studies are under way to determine the mechanisms of age and VE-induced enhancement of effective immune synapse formation...
  7. ncbi request reprint Age-associated inflammatory changes: role of nutritional intervention
    Simin Nikbin Meydani
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University Boston, Massachussetts 02111, USA
    Nutr Rev 65:S213-6. 2007
    ....
  8. pmc Serum zinc and pneumonia in nursing home elderly
    Simin N Meydani
    Nutritional Immunology Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 86:1167-73. 2007
    ..Zinc plays an important role in immune function. The association between serum zinc and pneumonia in the elderly has not been studied...
  9. doi request reprint Epigallocatechin-3-gallate directly suppresses T cell proliferation through impaired IL-2 utilization and cell cycle progression
    Munkyong Pae
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 140:1509-15. 2010
    ..CD4(+) cells are more responsive to EGCG than CD8(+) cells. Future studies should determine the effect of EGCG on CD4(+) cell subsets to assess its application in T cell-mediated autoimmune diseases...
  10. ncbi request reprint Effect of hydrogenated and saturated, relative to polyunsaturated, fat on immune and inflammatory responses of adults with moderate hypercholesterolemia
    Sung Nim Han
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Lipid Res 43:445-52. 2002
    ....
  11. pmc Low zinc status: a new risk factor for pneumonia in the elderly?
    Junaidah B Barnett
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, the Nutrition Infection Unit, Department of Public Health and Family Medicine, Tufts University School of Medicine, the Friedman School of Nutrition Science and Policy at Tufts University, Boston, MA 02111, USA
    Nutr Rev 68:30-7. 2010
    ..Randomized, double-blind, controlled studies are needed to determine the efficacy of zinc supplementation as a potential low-cost intervention to reduce morbidity and mortality due to pneumonia in this vulnerable population...
  12. pmc Patterns of antimicrobial use for respiratory tract infections in older residents of long-term care facilities
    Paschalis Vergidis
    Section of Infectious Diseases, Department of Medicine, School of Medicine, Center for Global Health and Development, Boston University, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 59:1093-8. 2011
    ..To describe patterns of antimicrobial use for respiratory tract infections (RTIs) in older residents of long-term care facilities (LTCFs)...
  13. pmc Vitamin E reverses impaired linker for activation of T cells activation in T cells from aged C57BL/6 mice
    Melissa G Marko
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:1192-7. 2009
    ..Furthermore, neither age nor vitamin E influenced the phosphorylation of Lck and Zap70, indicating that associated changes in LAT phosphorylation were not caused by alterations in activation states of the upstream kinases Lck and Zap70...
  14. ncbi request reprint Mechanism of vitamin E inhibition of cyclooxygenase activity in macrophages from old mice: role of peroxynitrite
    Alison A Beharka
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Free Radic Biol Med 32:503-11. 2002
    ..These findings have important implications for designing interventions to reverse and/or delay age-associated dysregulation of immune and inflammatory responses and diseases associated with them...
  15. ncbi request reprint Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated through up-regulation of NF-kappa B activity
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 278:10983-92. 2003
    ..These findings strongly suggest that the age-associated and ceramide-induced increase in COX-2 transcription is mediated through higher NF-kappa B activation, which is, in turn, because of a greater I kappa B degradation in old M phi...
  16. pmc Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention
    Dayong Wu
    Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    J Leukoc Biol 84:900-14. 2008
    ..This review will discuss the above age-related immune and inflammatory changes and the effect of vitamin E as nutritional intervention with a focus on the work conducted in our laboratory...
  17. ncbi request reprint Strategies, time, and costs associated with the recruitment and enrollment of nursing home residents for a micronutrient supplementation clinical trial
    Paula M Gismondi
    DVM, Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University, 711 Washington St, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 60:1469-74. 2005
    ..The information available on strategies for the recruitment and screening of participants for such studies in long-term care facilities, as well as the financial and time costs for carrying out these investigations, is limited...
  18. ncbi request reprint Effect of concomitant consumption of fish oil and vitamin E on T cell mediated function in the elderly: a randomized double-blind trial
    Dayong Wu
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Am Coll Nutr 25:300-6. 2006
    ..To determine if concomitant consumption of fish oil and vitamin E would modify the vitamin E level needed for improving T cell mediated function in elderly...
  19. ncbi request reprint White button mushroom enhances maturation of bone marrow-derived dendritic cells and their antigen presenting function in mice
    Zhihong Ren
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 138:544-50. 2008
    ..This effect may have potential in enhancing both innate and T cell-mediated immunity leading to a more efficient surveillance and defense mechanism against microbial invasion and tumor development...
  20. ncbi request reprint Age-associated decline in effective immune synapse formation of CD4(+) T cells is reversed by vitamin E supplementation
    Melissa G Marko
    Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Immunol 178:1443-9. 2007
    ..These data show, for the first time, that vitamin E significantly improves age-related early T cell signaling events in naive CD4(+) T cells...
  21. ncbi request reprint Ceramide mediates age-associated increase in macrophage cyclooxygenase-2 expression
    Kate J Claycombe
    Nutritional Immunology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center at Tufts University, 711 Washington Street, Boston, MA 02111
    J Biol Chem 277:30784-91. 2002
    ..Furthermore, this increase in transcription is mediated by higher cellular ceramide concentration in old MØ compared with that of young MØ...
  22. ncbi request reprint Dietary supplementation with white button mushroom enhances natural killer cell activity in C57BL/6 mice
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 137:1472-7. 2007
    ..This effect might be mediated through increased IFNgamma and TNFalpha production...
  23. ncbi request reprint Aging up-regulates expression of inflammatory mediators in mouse adipose tissue
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer Unites States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Immunol 179:4829-39. 2007
    ....
  24. doi request reprint Green tea EGCG suppresses T cell proliferation through impairment of IL-2/IL-2 receptor signaling
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Free Radic Biol Med 47:636-43. 2009
    ....
  25. ncbi request reprint Impact of vitamin E on immune function and its clinical implications
    Sung Nim Han
    Tufts University, Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, 711 Washington Street, Boston, MA 02111, USA
    Expert Rev Clin Immunol 2:561-7. 2006
    ....
  26. ncbi request reprint Age and vitamin E-induced changes in gene expression profiles of T cells
    Sung Nim Han
    Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Immunol 177:6052-61. 2006
    ..Further studies are needed to determine whether these changes are due to the effects of aging at a single-cell level or to the shift in the ratio of naïve:memory T cells with age...
  27. ncbi request reprint Mechanism of age-associated up-regulation in macrophage PGE2 synthesis
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Brain Behav Immun 18:487-94. 2004
    ..Further understanding of molecular mechanisms involved in COX-2 up-regulation will help in delineating fundamental age-related changes, which lead to the development of immune and neurological disorders in the aged...
  28. ncbi request reprint Vitamin E supplementation does not alter azoxymethane-induced colonic aberrant crypt foci formation in young or old mice
    Heekyung Chung
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:528-32. 2003
    ..Whether vitamin E supplementation might be effective in reducing AOM-induced colon tumors is unclear...
  29. ncbi request reprint Vitamin E increases production of vasodilator prostanoids in human aortic endothelial cells through opposing effects on cyclooxygenase-2 and phospholipase A2
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 135:1847-53. 2005
    ..The vitamin E-induced increase in PGI(2) and PGE(2) production may contribute to its suggested beneficial effect in preserving endothelial function...
  30. ncbi request reprint Vitamin E and gene expression in immune cells
    Sung Nim Han
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:96-101. 2004
    ..Aging had significant effects on genes involved in signal transduction, transcriptional regulation, and apoptosis pathways in T cells, while vitamin E had a significant effect on genes associated with the regulation of cell cycle...
  31. ncbi request reprint Effect of vitamin E on prostacyclin (PGI2) and prostaglandin (PG) E2 production by human aorta endothelial cells: mechanism of action
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:425-7. 2004
    ..This effect of vitamin E is due to increased release of substrate arachidonic acid, which in turn results from increased expression of phospholipase A(2) (PLA(2))...
  32. ncbi request reprint Effect of concomitant consumption of fish oil and vitamin E on production of inflammatory cytokines in healthy elderly humans
    Dayong Wu
    D V M, Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:422-4. 2004
    ....
  33. ncbi request reprint Effect of a therapeutic lifestyle change diet on immune functions of moderately hypercholesterolemic humans
    Sung Nim Han
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 44:2304-10. 2003
    ..This might be a clinically important benefit, considering the decline of T cell-mediated immune functions with aging and evidence of impaired immune function associated with hypercholesterolemia...
  34. pmc Cytokine response to vitamin E supplementation is dependent on pre-supplementation cytokine levels
    Sarah E Belisle
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston 02111, MA, USA
    Biofactors 33:191-200. 2008
    ..Our results could have implications in designing clinical trials to determine the impact of vitamin E on conditions in which cytokines are implicated such as infections and atherosclerotic disease...
  35. ncbi request reprint Effect of age on susceptibility to azoxymethane-induced colonic aberrant crypt foci formation in C57BL/6JNIA mice
    Heekyung Chung
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 58:B400-5. 2003
    ..These age differences are not due to variations in cyclooxygenase-2 expression, cell proliferation, or AOM hydroxylase activity...
  36. pmc Effect of age on susceptibility to Salmonella Typhimurium infection in C57BL/6 mice
    Zhihong Ren
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Med Microbiol 58:1559-67. 2009
    ..Typhimurium infection compared to young mice...
  37. doi request reprint Dietary supplementation with tocotrienols enhances immune function in C57BL/6 mice
    Zhihong Ren
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 140:1335-41. 2010
    ..All T3 enhanced lymphocyte proliferation in old but not young mice with a potency order of alpha- > gamma- > delta-T3. Together, these results suggest a beneficial effect of T3 in improving the age-related decline in T cell function...
  38. ncbi request reprint Nutrition and the aging immune response
    Oskar Adolfsson
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Nestle Nutr Workshop Ser Clin Perform Programme 6:207-20; discussion 220-1. 2002
  39. ncbi request reprint The effect of vitamin E on secondary bacterial infection after influenza infection in young and old mice
    Raina Gay
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:418-21. 2004
    ..E supplementation did not have a significant effect on SA infection alone. However, E supplementation abolished the priming effect of influenza on SA...
  40. doi request reprint Obesity impairs cell-mediated immunity during the second trimester of pregnancy
    Sarbattama Sen
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Am J Obstet Gynecol 208:139.e1-8. 2013
    ..Obese pregnancy is associated with significantly higher rates of infection, which can harm both mother and fetus. The objective of this study was to determine the impact of obesity on maternal blood immune function...
  41. doi request reprint Epigallocatechin-3-gallate ameliorates experimental autoimmune encephalomyelitis by altering balance among CD4+ T-cell subsets
    Junpeng Wang
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Sackler Graduate School of Biochemical Sciences, Tufts University, Boston, Massachusetts 02111, USA
    Am J Pathol 180:221-34. 2012
    ..Thus, we identified a novel mechanism that underlies EGCG's beneficial effect in autoimmune disease...
  42. ncbi request reprint Metabolic aging and predicted longevity: results of a cross-sectional study in post-menopausal women
    Nicholas P Hays
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Aging Clin Exp Res 14:465-73. 2002
    ..The objective of this study was to examine the association of age-related physiological and metabolic variables with predicted longevity in postmenopausal women...
  43. pmc A trial of the effect of micronutrient supplementation on treatment outcome, T cell counts, morbidity, and mortality in adults with pulmonary tuberculosis
    Eduardo Villamor
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Infect Dis 197:1499-505. 2008
    ..Tuberculosis (TB) often coincides with nutritional deficiencies. The effects of micronutrient supplementation on TB treatment outcomes, clinical complications, and mortality are uncertain...
  44. ncbi request reprint Altered memory B-cell homeostasis in human aging
    Eyal Breitbart
    Department of Biochemistry, Tufts University School of Medicine, and the Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts 02111, USA
    J Gerontol A Biol Sci Med Sci 57:B304-11. 2002
    ....
  45. pmc Polymorphisms at cytokine genes may determine the effect of vitamin E on cytokine production in the elderly
    Sarah E Belisle
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:1855-60. 2009
    ..Further studies are needed to determine the biological mechanism driving the interaction between vitamin E treatment and TNFalpha -308G > A and its implications for disease resistance...
  46. pmc Calorie restriction enhances T-cell-mediated immune response in adult overweight men and women
    Tanvir Ahmed
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 64:1107-13. 2009
    ..001). Lipopolysaccharide-stimulated PGE(2) was reduced in both groups but reached statistical significance after 30% CR (p < or = .029). These results, for the first time, show that 6-month CR in humans improves T-cell function...
  47. pmc Fish oil supplementation inhibits NNK-induced lung carcinogenesis in the A/J mouse
    Heather Mernitz
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Nutr Cancer 61:663-9. 2009
    ..These data suggest that fish oil with a low ratio of n-6/n-3 PUFA could be beneficial in the prevention of lung carcinogenesis...
  48. pmc An aged host promotes the evolution of avirulent coxsackievirus into a virulent strain
    Raina T Gay
    Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 103:13825-30. 2006
    ..These results demonstrate that the aged host promotes rapid selection of a pathogenic variant of CVB3 from an avirulent strain and introduces a host-virus paradigm for studies of viral infection in the aged...
  49. pmc Micronutrient deficiencies are associated with impaired immune response and higher burden of respiratory infections in elderly Ecuadorians
    Davidson H Hamer
    Jean Mayer USDA Human Nutrition Research Center on the Aging, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA
    J Nutr 139:113-9. 2009
    ..Deficiencies of essential vitamins and minerals place these elderly adults at risk for infections through their negative impact on immune function...
  50. ncbi request reprint Nutritional, immunological and health status of the elderly population living in poor neighbourhoods of Quito, Ecuador
    Fernando Sempertegui
    Corporación Ecuatoriana de Biotecnología, Ave Colón 1468 y Nueve de Octubre Of 508, Quito, Ecuador
    Br J Nutr 96:845-53. 2006
    ..In conclusion, while few elderly Ecuadorians were underweight, obesity was common. Micronutrient deficiencies were prevalent and may contribute to reduced immunological responses in this population...
  51. pmc Long-term care facilities: a cornucopia of viral pathogens
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, New York 14621, USA
    J Am Geriatr Soc 56:1281-5. 2008
    ..To determine the frequency and types of respiratory viruses circulating in Boston long-term care facilities (LTCFs) during a 3-year period...
  52. ncbi request reprint High-dosage vitamin E supplementation and all-cause mortality
    Simin Nikbin Meydani
    Ann Intern Med 143:153; author reply 156-8. 2005
  53. ncbi request reprint Aging, nutritional status, and infection in the developing world
    Ahou Meydani
    Yale School of Medicine, New Haven, Connecticut, USA
    Nutr Rev 63:233-46. 2005
    ....
  54. ncbi request reprint Severe folate deficiency impairs natural killer cell-mediated cytotoxicity in rats
    Young In Kim
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Nutr 132:1361-7. 2002
    ..These data collectively suggest that NK-mediated cytotoxicity is not a likely mechanism by which folate status modulates carcinogenesis...

Research Grants29

  1. Aging: Mechanism & Prevention: 35th Annual Meeting of AGE
    Simin Meydani; Fiscal Year: 2006
    ..Special efforts will be devoted to encourage participation of underrepresented minorities. The meeting will be preceded by a Pre-conference on Calorie restriction. ..
  2. Calorie Restriction and immune Response in Humans
    Simin Meydani; Fiscal Year: 2007
    ....
  3. Aging Vitamin E, and Immune Function in Aged
    Simin Meydani; Fiscal Year: 2007
    ..This, in turn, will help in designing practical nutritional interventions to reverse and/or delay the age-associated dysregulation of immune and inflammatory responses as well as diseases associated with it. ..
  4. Age-related changes in the proteome and lipidome of the immunological synapse
    Simin Meydani; Fiscal Year: 2007
    ..This map will enhance our understanding of the molecular bases of immune senescence, and will promote the development of strategies to reverse the detrimental changes associated with aging. ..
  5. VITAMIN E AND INFECTION IN THE ELDERLY
    Simin Meydani; Fiscal Year: 2001
    ..The results are intended to provide basic and applied insight into the mechanisms involved, the goals to be realized, and ways to sharpen the intervention and enhance its impact. ..
  6. VITAMIN E AND THE AGING IMMUNE RESPONSE
    Simin Meydani; Fiscal Year: 1992
    ....
  7. AGING, VITAMIN E, & MACROPHAGE CYCLOOXYGENASE REGULATION
    Simin Meydani; Fiscal Year: 2000
    ....
  8. Calorie Restriction and immune Response in Humans
    Simin Nikbin Meydani; Fiscal Year: 2010
    ....