Research Topics
Species | Simin N MeydaniSummaryAffiliation: Tufts University Country: USA Publications
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Publications
Vitamin E and respiratory infection in the elderlySimin Nikbin Meydani
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Ann N Y Acad Sci 1031:214-22. 2004....- Age-associated inflammatory changes: role of nutritional interventionSimin Nikbin Meydani
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University Boston, Massachussetts 02111, USA
Nutr Rev 65:S213-6. 2007.... - Vitamin E and immune response in the aged: molecular mechanisms and clinical implicationsSimin Nikbin Meydani
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Immunol Rev 205:269-84. 2005..Further studies are needed to determine the signaling mechanisms involved in the upregulation of naive T-cell function by vitamin E as well as the specific mechanisms involved in reduction of risk for upper respiratory infections... 
Serum zinc and pneumonia in nursing home elderlySimin N Meydani
Nutritional Immunology Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 86:1167-73. 2007..Zinc plays an important role in immune function. The association between serum zinc and pneumonia in the elderly has not been studied...- Vitamin E supplementation reverses the age-associated decrease in effective immune synapse formation in CD4+ T cellsTanvir Ahmed
Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Ann N Y Acad Sci 1031:412-4. 2004..Further studies are under way to determine the mechanisms of age and VE-induced enhancement of effective immune synapse formation... 
Nutrition and age-associated inflammation: implications for disease preventionSimin Nikbin Meydani
JMUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
JPEN J Parenter Enteral Nutr 32:626-9. 2008..Nutrient/dietary medications, such as antioxidants and certain lipids have suggested a promising route to reduce the age-related increase in COX activity and PGE(2) production that is associated with several disease states...- Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trialSimin Nikbin Meydani
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Mass 02111, USA
JAMA 292:828-36. 2004..Vitamin E supplementation has been shown to improve immune response in elderly persons. However, the clinical importance of these findings has not been determined... - Epigallocatechin-3-gallate directly suppresses T cell proliferation through impaired IL-2 utilization and cell cycle progressionMunkyong Pae
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 140:1509-15. 2010..CD4(+) cells are more responsive to EGCG than CD8(+) cells. Future studies should determine the effect of EGCG on CD4(+) cell subsets to assess its application in T cell-mediated autoimmune diseases... - Effect of hydrogenated and saturated, relative to polyunsaturated, fat on immune and inflammatory responses of adults with moderate hypercholesterolemiaSung Nim Han
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
J Lipid Res 43:445-52. 2002.... - Low zinc status: a new risk factor for pneumonia in the elderly?Junaidah B Barnett
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, the Nutrition Infection Unit, Department of Public Health and Family Medicine, Tufts University School of Medicine, the Friedman School of Nutrition Science and Policy at Tufts University, Boston, MA 02111, USA
Nutr Rev 68:30-7. 2010..Randomized, double-blind, controlled studies are needed to determine the efficacy of zinc supplementation as a potential low-cost intervention to reduce morbidity and mortality due to pneumonia in this vulnerable population... - Patterns of antimicrobial use for respiratory tract infections in older residents of long-term care facilitiesPaschalis Vergidis
Section of Infectious Diseases, Department of Medicine, School of Medicine, Center for Global Health and Development, Boston University, Boston, Massachusetts 02118, USA
J Am Geriatr Soc 59:1093-8. 2011..To describe patterns of antimicrobial use for respiratory tract infections (RTIs) in older residents of long-term care facilities (LTCFs)... - Vitamin E reverses impaired linker for activation of T cells activation in T cells from aged C57BL/6 miceMelissa G Marko
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 139:1192-7. 2009..Furthermore, neither age nor vitamin E influenced the phosphorylation of Lck and Zap70, indicating that associated changes in LAT phosphorylation were not caused by alterations in activation states of the upstream kinases Lck and Zap70... - Age-associated changes in immune and inflammatory responses: impact of vitamin E interventionDayong Wu
Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
J Leukoc Biol 84:900-14. 2008..This review will discuss the above age-related immune and inflammatory changes and the effect of vitamin E as nutritional intervention with a focus on the work conducted in our laboratory... - Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated through up-regulation of NF-kappa B activityDayong Wu
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
J Biol Chem 278:10983-92. 2003..These findings strongly suggest that the age-associated and ceramide-induced increase in COX-2 transcription is mediated through higher NF-kappa B activation, which is, in turn, because of a greater I kappa B degradation in old M phi... - Mechanism of vitamin E inhibition of cyclooxygenase activity in macrophages from old mice: role of peroxynitriteAlison A Beharka
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Free Radic Biol Med 32:503-11. 2002..These findings have important implications for designing interventions to reverse and/or delay age-associated dysregulation of immune and inflammatory responses and diseases associated with them... - Strategies, time, and costs associated with the recruitment and enrollment of nursing home residents for a micronutrient supplementation clinical trialPaula M Gismondi
DVM, Nutritional Immunology Laboratory, Jean Mayer/USDA Human Nutrition Research Center on Aging Tufts University, 711 Washington St, Boston, MA 02111, USA
J Gerontol A Biol Sci Med Sci 60:1469-74. 2005.... - Age-associated decline in effective immune synapse formation of CD4(+) T cells is reversed by vitamin E supplementationMelissa G Marko
Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Immunol 178:1443-9. 2007..These data show, for the first time, that vitamin E significantly improves age-related early T cell signaling events in naive CD4(+) T cells... - Effect of concomitant consumption of fish oil and vitamin E on T cell mediated function in the elderly: a randomized double-blind trialDayong Wu
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Am Coll Nutr 25:300-6. 2006..CONCLUSIONS: The immuno-enhancing effect of vitamin E in the elderly is dampened when it is concomitantly consumed with fish oil. This may be due to the smaller increase in plasma concentrations of vitamin E in the presence of fish oil... - Ceramide mediates age-associated increase in macrophage cyclooxygenase-2 expressionKate J Claycombe
Nutritional Immunology Laboratory, Jean Mayer United States Department of Agriculture/Human Nutrition Research Center at Tufts University, 711 Washington Street, Boston, MA 02111
J Biol Chem 277:30784-91. 2002..Furthermore, this increase in transcription is mediated by higher cellular ceramide concentration in old MØ compared with that of young MØ... - White button mushroom enhances maturation of bone marrow-derived dendritic cells and their antigen presenting function in miceZhihong Ren
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 138:544-50. 2008..This effect may have potential in enhancing both innate and T cell-mediated immunity leading to a more efficient surveillance and defense mechanism against microbial invasion and tumor development... - Aging up-regulates expression of inflammatory mediators in mouse adipose tissueDayong Wu
Nutritional Immunology Laboratory, Jean Mayer Unites States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Immunol 179:4829-39. 2007.... - Vitamin E increases production of vasodilator prostanoids in human aortic endothelial cells through opposing effects on cyclooxygenase-2 and phospholipase A2Dayong Wu
Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr 135:1847-53. 2005..The vitamin E-induced increase in PGI(2) and PGE(2) production may contribute to its suggested beneficial effect in preserving endothelial function... - Dietary supplementation with white button mushroom enhances natural killer cell activity in C57BL/6 miceDayong Wu
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 137:1472-7. 2007..This effect might be mediated through increased IFNgamma and TNFalpha production... - Impact of vitamin E on immune function and its clinical implicationsSung Nim Han
Tufts University, Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, 711 Washington Street, Boston, MA 02111, USA
Expert Rev Clin Immunol 2:561-7. 2006.... - Green tea EGCG suppresses T cell proliferation through impairment of IL-2/IL-2 receptor signalingDayong Wu
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Free Radic Biol Med 47:636-43. 2009.... - Age and vitamin E-induced changes in gene expression profiles of T cellsSung Nim Han
Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
J Immunol 177:6052-61. 2006..Further studies are needed to determine whether these changes are due to the effects of aging at a single-cell level or to the shift in the ratio of naïve:memory T cells with age... - Vitamin E and gene expression in immune cellsSung Nim Han
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Ann N Y Acad Sci 1031:96-101. 2004..Aging had significant effects on genes involved in signal transduction, transcriptional regulation, and apoptosis pathways in T cells, while vitamin E had a significant effect on genes associated with the regulation of cell cycle... - Mechanism of age-associated up-regulation in macrophage PGE2 synthesisDayong Wu
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Brain Behav Immun 18:487-94. 2004..Further understanding of molecular mechanisms involved in COX-2 up-regulation will help in delineating fundamental age-related changes, which lead to the development of immune and neurological disorders in the aged... - Effect of concomitant consumption of fish oil and vitamin E on production of inflammatory cytokines in healthy elderly humansDayong Wu
D V M, Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Ann N Y Acad Sci 1031:422-4. 2004.... - Effect of vitamin E on prostacyclin (PGI2) and prostaglandin (PG) E2 production by human aorta endothelial cells: mechanism of actionDayong Wu
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Ann N Y Acad Sci 1031:425-7. 2004..This effect of vitamin E is due to increased release of substrate arachidonic acid, which in turn results from increased expression of phospholipase A(2) (PLA(2))... - Vitamin E supplementation does not alter azoxymethane-induced colonic aberrant crypt foci formation in young or old miceHeekyung Chung
Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Nutr 133:528-32. 2003..Whether vitamin E supplementation might be effective in reducing AOM-induced colon tumors is unclear... - Effect of a therapeutic lifestyle change diet on immune functions of moderately hypercholesterolemic humansSung Nim Han
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Lipid Res 44:2304-10. 2003..This might be a clinically important benefit, considering the decline of T cell-mediated immune functions with aging and evidence of impaired immune function associated with hypercholesterolemia... - Effect of age on susceptibility to Salmonella Typhimurium infection in C57BL/6 miceZhihong Ren
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
J Med Microbiol 58:1559-67. 2009..Typhimurium infection compared to young mice... - Cytokine response to vitamin E supplementation is dependent on pre-supplementation cytokine levelsSarah E Belisle
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston 02111, MA, USA
Biofactors 33:191-200. 2008..Our results could have implications in designing clinical trials to determine the impact of vitamin E on conditions in which cytokines are implicated such as infections and atherosclerotic disease... - Effect of age on susceptibility to azoxymethane-induced colonic aberrant crypt foci formation in C57BL/6JNIA miceHeekyung Chung
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
J Gerontol A Biol Sci Med Sci 58:B400-5. 2003..These age differences are not due to variations in cyclooxygenase-2 expression, cell proliferation, or AOM hydroxylase activity... - Nutrition and the aging immune responseOskar Adolfsson
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
Nestle Nutr Workshop Ser Clin Perform Programme 6:207-20; discussion 220-1. 2002 - Dietary supplementation with tocotrienols enhances immune function in C57BL/6 miceZhihong Ren
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 140:1335-41. 2010..All T3 enhanced lymphocyte proliferation in old but not young mice with a potency order of alpha- > gamma- > delta-T3. Together, these results suggest a beneficial effect of T3 in improving the age-related decline in T cell function... - The effect of vitamin E on secondary bacterial infection after influenza infection in young and old miceRaina Gay
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Ann N Y Acad Sci 1031:418-21. 2004..E supplementation did not have a significant effect on SA infection alone. However, E supplementation abolished the priming effect of influenza on SA... - Obesity impairs cell-mediated immunity during the second trimester of pregnancySarbattama Sen
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
Am J Obstet Gynecol 208:139.e1-8. 2013..Obese pregnancy is associated with significantly higher rates of infection, which can harm both mother and fetus. The objective of this study was to determine the impact of obesity on maternal blood immune function... - Epigallocatechin-3-gallate ameliorates experimental autoimmune encephalomyelitis by altering balance among CD4+ T-cell subsetsJunpeng Wang
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Sackler Graduate School of Biochemical Sciences, Tufts University, Boston, Massachusetts 02111, USA
Am J Pathol 180:221-34. 2012..Thus, we identified a novel mechanism that underlies EGCG's beneficial effect in autoimmune disease... - A trial of the effect of micronutrient supplementation on treatment outcome, T cell counts, morbidity, and mortality in adults with pulmonary tuberculosisEduardo Villamor
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
J Infect Dis 197:1499-505. 2008..Tuberculosis (TB) often coincides with nutritional deficiencies. The effects of micronutrient supplementation on TB treatment outcomes, clinical complications, and mortality are uncertain... - Metabolic aging and predicted longevity: results of a cross-sectional study in post-menopausal womenNicholas P Hays
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
Aging Clin Exp Res 14:465-73. 2002..Although the small sample size may have limited the ability to detect metabolic effects on longevity in this study, the general approach may be broadly applicable to examinations of metabolic aging in humans... - Calorie restriction enhances T-cell-mediated immune response in adult overweight men and womenTanvir Ahmed
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Gerontol A Biol Sci Med Sci 64:1107-13. 2009..001). Lipopolysaccharide-stimulated PGE(2) was reduced in both groups but reached statistical significance after 30% CR (p < or = .029). These results, for the first time, show that 6-month CR in humans improves T-cell function... - Polymorphisms at cytokine genes may determine the effect of vitamin E on cytokine production in the elderlySarah E Belisle
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 139:1855-60. 2009..Further studies are needed to determine the biological mechanism driving the interaction between vitamin E treatment and TNFalpha -308G > A and its implications for disease resistance... - Altered memory B-cell homeostasis in human agingEyal Breitbart
Department of Biochemistry, Tufts University School of Medicine, and the Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts 02111, USA
J Gerontol A Biol Sci Med Sci 57:B304-11. 2002.... - Fish oil supplementation inhibits NNK-induced lung carcinogenesis in the A/J mouseHeather Mernitz
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Nutr Cancer 61:663-9. 2009..These data suggest that fish oil with a low ratio of n-6/n-3 PUFA could be beneficial in the prevention of lung carcinogenesis... - An aged host promotes the evolution of avirulent coxsackievirus into a virulent strainRaina T Gay
Nutritional Immunology Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 103:13825-30. 2006..These results demonstrate that the aged host promotes rapid selection of a pathogenic variant of CVB3 from an avirulent strain and introduces a host-virus paradigm for studies of viral infection in the aged... - Micronutrient deficiencies are associated with impaired immune response and higher burden of respiratory infections in elderly EcuadoriansDavidson H Hamer
Jean Mayer USDA Human Nutrition Research Center on the Aging, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA
J Nutr 139:113-9. 2009..Deficiencies of essential vitamins and minerals place these elderly adults at risk for infections through their negative impact on immune function... - Nutritional, immunological and health status of the elderly population living in poor neighbourhoods of Quito, EcuadorFernando Sempertegui
Corporación Ecuatoriana de Biotecnología, Ave Colón 1468 y Nueve de Octubre Of 508, Quito, Ecuador
Br J Nutr 96:845-53. 2006..In conclusion, while few elderly Ecuadorians were underweight, obesity was common. Micronutrient deficiencies were prevalent and may contribute to reduced immunological responses in this population... - Long-term care facilities: a cornucopia of viral pathogensAnn R Falsey
Department of Medicine, Rochester General Hospital, Rochester, New York 14621, USA
J Am Geriatr Soc 56:1281-5. 2008..To determine the frequency and types of respiratory viruses circulating in Boston long-term care facilities (LTCFs) during a 3-year period... - Aging, nutritional status, and infection in the developing worldAhou Meydani
Yale School of Medicine, New Haven, Connecticut, USA
Nutr Rev 63:233-46. 2005.... - High-dosage vitamin E supplementation and all-cause mortalitySimin Nikbin Meydani
Ann Intern Med 143:153; author reply 156-8. 2005 - Severe folate deficiency impairs natural killer cell-mediated cytotoxicity in ratsYoung In Kim
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Nutr 132:1361-7. 2002..These data collectively suggest that NK-mediated cytotoxicity is not a likely mechanism by which folate status modulates carcinogenesis...
Research Grants
- Aging: Mechanism & Prevention: 35th Annual Meeting of AGESimin Meydani; Fiscal Year: 2006..Special efforts will be devoted to encourage participation of underrepresented minorities. The meeting will be preceded by a Pre-conference on Calorie restriction. ..
- Calorie Restriction and immune Response in HumansSimin Meydani; Fiscal Year: 2007....
- Aging Vitamin E, and Immune Function in AgedSimin Meydani; Fiscal Year: 2007..This, in turn, will help in designing practical nutritional interventions to reverse and/or delay the age-associated dysregulation of immune and inflammatory responses as well as diseases associated with it. ..
- Age-related changes in the proteome and lipidome of the immunological synapseSimin Meydani; Fiscal Year: 2007..This map will enhance our understanding of the molecular bases of immune senescence, and will promote the development of strategies to reverse the detrimental changes associated with aging. ..
- VITAMIN E AND INFECTION IN THE ELDERLYSimin Meydani; Fiscal Year: 2001..The results are intended to provide basic and applied insight into the mechanisms involved, the goals to be realized, and ways to sharpen the intervention and enhance its impact. ..
- VITAMIN E AND THE AGING IMMUNE RESPONSESimin Meydani; Fiscal Year: 1992....
- AGING, VITAMIN E, & MACROPHAGE CYCLOOXYGENASE REGULATIONSimin Meydani; Fiscal Year: 2000....
- Calorie Restriction and immune Response in HumansSimin Nikbin Meydani; Fiscal Year: 2010....