M Meydani

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint The Boyd Orr lecture. Nutrition interventions in aging and age-associated disease
    Mohsen Meydani
    Vascular Biology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Proc Nutr Soc 61:165-71. 2002
  2. ncbi request reprint Nutrition interventions in aging and age-associated disease
    M Meydani
    Vascular Biology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Tufts University, Medford, Massachusetts 02155, USA
    Ann N Y Acad Sci 928:226-35. 2001
  3. ncbi request reprint Effect of functional food ingredients: vitamin E modulation of cardiovascular diseases and immune status in the elderly
    M Meydani
    Vascular Biology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 71:1665S-8S; discussion 1674S-5S. 2000
  4. ncbi request reprint Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice
    R D Lipman
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Mech Ageing Dev 103:269-84. 1998
  5. ncbi request reprint Effect of long-term dietary antioxidant supplementation on influenza virus infection
    S N Han
    Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Gerontol A Biol Sci Med Sci 55:B496-503. 2000
  6. ncbi request reprint The effect of long-term dietary supplementation with antioxidants
    M Meydani
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Ann N Y Acad Sci 854:352-60. 1998
  7. ncbi request reprint Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial
    S N Meydani
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    JAMA 277:1380-6. 1997
  8. ncbi request reprint Influence of dietary fat, vitamin E, ethoxyquin and indomethacin on the synthesis of prostaglandin E2 in brain regions of mice
    M Meydani
    U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111
    J Nutr 121:438-44. 1991
  9. pmc The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: results from the CALERIE Trial of Human Caloric Restriction
    M Meydani
    USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Nutr Health Aging 15:456-60. 2011
  10. ncbi request reprint The effects of dietary antioxidants on psychomotor performance in aged mice
    B Shukitt-Hale
    United States Department of Agriculture Agricultural Research Service, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Exp Gerontol 34:797-808. 1999

Collaborators

Detail Information

Publications41

  1. ncbi request reprint The Boyd Orr lecture. Nutrition interventions in aging and age-associated disease
    Mohsen Meydani
    Vascular Biology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Proc Nutr Soc 61:165-71. 2002
    ....
  2. ncbi request reprint Nutrition interventions in aging and age-associated disease
    M Meydani
    Vascular Biology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Tufts University, Medford, Massachusetts 02155, USA
    Ann N Y Acad Sci 928:226-35. 2001
    ....
  3. ncbi request reprint Effect of functional food ingredients: vitamin E modulation of cardiovascular diseases and immune status in the elderly
    M Meydani
    Vascular Biology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 71:1665S-8S; discussion 1674S-5S. 2000
    ....
  4. ncbi request reprint Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice
    R D Lipman
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Mech Ageing Dev 103:269-84. 1998
    ..Thus, diet supplementation with antioxidants initiated during middle age did not appear to affect age-associated lesions patterns, lesion burden or longevity for ad libitum fed male C57BL/6 mice...
  5. ncbi request reprint Effect of long-term dietary antioxidant supplementation on influenza virus infection
    S N Han
    Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Gerontol A Biol Sci Med Sci 55:B496-503. 2000
    ....
  6. ncbi request reprint The effect of long-term dietary supplementation with antioxidants
    M Meydani
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Ann N Y Acad Sci 854:352-60. 1998
    ..Further studies are needed to determine the effect of antioxidant supplementation on longevity in the context of moderate caloric restriction...
  7. ncbi request reprint Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial
    S N Meydani
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    JAMA 277:1380-6. 1997
    ..To determine whether long-term supplementation with vitamin E enhances in vivo, clinically relevant measures of cell-mediated immunity in healthy elderly subjects...
  8. ncbi request reprint Influence of dietary fat, vitamin E, ethoxyquin and indomethacin on the synthesis of prostaglandin E2 in brain regions of mice
    M Meydani
    U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111
    J Nutr 121:438-44. 1991
    ..The reduction of PGE2 synthesis in the brain with fish oil feeding in this study was not as notable as reported for other tissues unless combined with high-dose vitamin E supplementation...
  9. pmc The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: results from the CALERIE Trial of Human Caloric Restriction
    M Meydani
    USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Nutr Health Aging 15:456-60. 2011
    ..These findings indicate that short term CR (10% or 30%) in moderately overweight subjects modulates some but not all measures of antioxidant defense and oxidative stress...
  10. ncbi request reprint The effects of dietary antioxidants on psychomotor performance in aged mice
    B Shukitt-Hale
    United States Department of Agriculture Agricultural Research Service, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Exp Gerontol 34:797-808. 1999
    ....
  11. ncbi request reprint Assessment of the safety of supplementation with different amounts of vitamin E in healthy older adults
    S N Meydani
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 68:311-8. 1998
    ..Thus, 4 mo of supplementation with 60-800 IU vitamin E/d had no adverse effects. These results are relevant for determining risk-to-benefit ratios for vitamin E supplementation...
  12. ncbi request reprint Dietary antioxidants modulation of aging and immune-endothelial cell interaction
    M Meydani
    Vascular Biology Program, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Mech Ageing Dev 111:123-32. 1999
    ..Thus, antioxidants such as vitamin E from food sources or supplements appear to be promising for successful aging by improving immune function, and reducing the risk of several age-associated chronic diseases, such as CVD...
  13. doi request reprint Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice
    S T Hasan
    Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Atherosclerosis 232:40-51. 2014
    ..Thus, this study aimed to further elucidate the impact of increasing doses of curcumin on modulation of these molecular mediators on high fat diet-induced atherogenesis, inflammation, and steatohepatosis in Ldlr(-/-) mice...
  14. ncbi request reprint Vitamin E and atherosclerosis: beyond prevention of LDL oxidation
    M Meydani
    Vascular Biology Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 131:366S-8S. 2001
    ....
  15. ncbi request reprint Interleukin-6 production does not increase with age
    A A Beharka
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Gerontol A Biol Sci Med Sci 56:B81-8. 2001
    ..PGE2 and NO production were not affected by the addition of IL-6 to Mphi from young mice or anti-IL-6 antibody to Mphi from old mice. Thus, IL-6 does not appear to influence the Mphi production of selected inflammatory molecules...
  16. ncbi request reprint Green tea catechins and vitamin E inhibit angiogenesis of human microvascular endothelial cells through suppression of IL-8 production
    F Y Tang
    Vascular Biology Laboratory, JM USDA-Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Nutr Cancer 41:119-25. 2001
    ....
  17. ncbi request reprint Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells
    T Koga
    Vascular Biology Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston
    Am J Clin Nutr 73:941-8. 2001
    ..Metabolites of flavonoids, rather than their intact forms, may contribute to the reported effects of flavonoids on reducing the risk of cardiovascular disease...
  18. pmc alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice
    Sang Kyu Park
    Department of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA
    J Nutr 138:1010-8. 2008
    ..These results demonstrate that middle age-onset dietary supplementation with alphaT and gammaT can partially prevent age-associated transcriptional changes and that these effects are tissue and tocopherol specific...
  19. ncbi request reprint Effect of concomitant consumption of fish oil and vitamin E on T cell mediated function in the elderly: a randomized double-blind trial
    Dayong Wu
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Am Coll Nutr 25:300-6. 2006
    ..To determine if concomitant consumption of fish oil and vitamin E would modify the vitamin E level needed for improving T cell mediated function in elderly...
  20. ncbi request reprint A Mediterranean-style diet and metabolic syndrome
    Mohsen Meydani
    Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Nutr Rev 63:312-4. 2005
    ....
  21. ncbi request reprint Vitamin E increases production of vasodilator prostanoids in human aortic endothelial cells through opposing effects on cyclooxygenase-2 and phospholipase A2
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 135:1847-53. 2005
    ..The vitamin E-induced increase in PGI(2) and PGE(2) production may contribute to its suggested beneficial effect in preserving endothelial function...
  22. ncbi request reprint Effect of vitamin E on prostacyclin (PGI2) and prostaglandin (PG) E2 production by human aorta endothelial cells: mechanism of action
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:425-7. 2004
    ..This effect of vitamin E is due to increased release of substrate arachidonic acid, which in turn results from increased expression of phospholipase A(2) (PLA(2))...
  23. ncbi request reprint Vitamin E modulation of cardiovascular disease
    Mohsen Meydani
    Vascular Biology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Center on Aging at Tufts University, 711 Washington Street, Boston MA 02111, USA
    Ann N Y Acad Sci 1031:271-9. 2004
    ....
  24. ncbi request reprint Combined vitamin C and E supplementation retards early progression of arteriosclerosis in heart transplant patients
    Liping Liu
    Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Rev 60:368-71. 2002
    ....
  25. ncbi request reprint Antioxidants in the prevention of chronic diseases
    Mohsen Meydani
    Nutr Clin Care 5:47-9. 2002
  26. ncbi request reprint Effect of concomitant consumption of fish oil and vitamin E on production of inflammatory cytokines in healthy elderly humans
    Dayong Wu
    D V M, Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1031:422-4. 2004
    ....
  27. ncbi request reprint The antiatherogenic potential of oat phenolic compounds
    Liping Liu
    Vascular Biology Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 175:39-49. 2004
    ..These data provide evidence for the potential anti-inflammatory and antiatherogenic effects of antioxidant avenanthramides present in oats...
  28. ncbi request reprint Homocysteine increases monocyte and T-cell adhesion to human aortic endothelial cells
    Takuro Koga
    Vascular Biology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 161:365-74. 2002
    ..Dietary antioxidants such as vitamin E may attenuate HCY-stimulated activation of the endothelium and may help reduce the risk of vascular disease associated with hyperhomocysteinemia...
  29. ncbi request reprint Vitamin E supplementation suppresses macrophage accumulation and endothelial cell expression of adhesion molecules in the aorta of hypercholesterolemic rabbits
    Takuro Koga
    Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 176:265-72. 2004
    ....
  30. doi request reprint Genetic polymorphisms as determinants for disease-preventive effects of vitamin E
    Jean Marc Zingg
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Nutr Rev 66:406-14. 2008
    ....
  31. pmc PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases: the Boston Puerto Rican Health Study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Diabetes 57:809-16. 2008
    ....
  32. ncbi request reprint Avenanthramides, polyphenols from oats, inhibit IL-1beta-induced NF-kappaB activation in endothelial cells
    Weimin Guo
    Vascular Biology Laboratory, JM USDA Human Nutrition Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Free Radic Biol Med 44:415-29. 2008
    ....
  33. ncbi request reprint Molecular mechanism of alpha-tocopheryl-phosphate transport across the cell membrane
    Yesim Negis
    Vascular Biology Laboratory, The Jean Mayer USDA Human Nutrition Center at Tufts University, Boston, MA 02111, USA
    Biochem Biophys Res Commun 359:348-53. 2007
    ..Due to the protection by glibenclamide and probenecid on the alpha-TP induced cell growth inhibition it appears that alpha-TP acts after its uptake inside cells...
  34. ncbi request reprint Inverse association between prostatic polyunsaturated fatty acid and risk of locally advanced prostate carcinoma
    Vincent L Freeman
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois 60612 4336, USA
    Cancer 101:2744-54. 2004
    ....
  35. ncbi request reprint Soluble adhesion molecules: surrogate markers of cardiovascular disease?
    Mohsen Meydani
    Vascular Biology Lab, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Rev 61:63-8. 2003
    ....
  36. ncbi request reprint Green tea catechin, epigallocatechin-3-gallate, inhibits vascular endothelial growth factor angiogenic signaling by disrupting the formation of a receptor complex
    Shaun K Rodriguez
    Vascular Biology Laboratory, JM USDA Human Nutrition Center on Aging at Tufts University, Boston, MA 02111, USA
    Int J Cancer 118:1635-44. 2006
    ..These results suggest a novel mechanism for green tea's anticancer effects where EGCG can abrogate VEGF signaling by interfering with the formation of a receptor complex, resulting in attenuated mitogenic and angiogenic signaling...
  37. ncbi request reprint Bioavailability of soybean isoflavones from aglycone and glucoside forms in American women
    Ligia Zubik
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 77:1459-65. 2003
    ..Test results on the bioavailability of isoflavones in the aglycone or glucoside form in Eastern and Western human subjects are contradictory...
  38. ncbi request reprint Avenanthramide, a polyphenol from oats, inhibits vascular smooth muscle cell proliferation and enhances nitric oxide production
    Lin Nie
    Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 186:260-6. 2006
    ..These results suggest that the avenanthramides of oats may contribute to the prevention of atherosclerosis through inhibition of SMC proliferation and increasing NO production...
  39. ncbi request reprint High-dosage vitamin E supplementation and all-cause mortality
    Simin Nikbin Meydani
    Ann Intern Med 143:153; author reply 156-8. 2005
  40. ncbi request reprint Green tea catechins inhibit VEGF-induced angiogenesis in vitro through suppression of VE-cadherin phosphorylation and inactivation of Akt molecule
    Feng Yao Tang
    Vascular Biology Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Int J Cancer 106:871-8. 2003
    ..These findings indicate that VE-cadherin and Akt, known downstream proteins in VEGFR-2-mediated cascade, are the new-targeted proteins by which green tea catechins inhibit angiogenesis...
  41. ncbi request reprint Chemical structure of flavonols in relation to modulation of angiogenesis and immune-endothelial cell adhesion
    Jong Deog Kim
    Department of Biotechnology, Yosu National University, Yosu, Cheonnam, 550 260 South Korea
    J Nutr Biochem 17:165-76. 2006
    ....