Mitch McVey

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings
    Mitch McVey
    Department of Biology, Tufts University, 165 Packard Avenue, Medford, MA 02155, USA
    Trends Genet 24:529-38. 2008
  2. ncbi Strategies for DNA interstrand crosslink repair: insights from worms, flies, frogs, and slime molds
    Mitch McVey
    Department of Biology, Tufts University, Medford, Massachusetts 02155, USA
    Environ Mol Mutagen 51:646-58. 2010
  3. ncbi Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila
    Sze Ham Chan
    Department of Biology, Tufts University, Medford, Massachusetts, United States of America
    PLoS Genet 6:e1001005. 2010
  4. ncbi Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion
    Mitch McVey
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 101:15694-9. 2004
  5. ncbi Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions
    Amy Marie Yu
    Department of Biology, Tufts University, Medford, MA 02155, USA
    Nucleic Acids Res 38:5706-17. 2010
  6. ncbi Multiple functions of Drosophila BLM helicase in maintenance of genome stability
    Mitch McVey
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Genetics 176:1979-92. 2007
  7. ncbi Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila
    Ana Maria Garcia
    Department of Biology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
    Genome Biol 12:R121. 2011
  8. ncbi Super-sized deletions: improved transposon excision screens using a mus309 mutant background
    Alice Witsell
    Department of Biology, Tufts University, Medford, MA, USA
    Fly (Austin) 4:137-40. 2010
  9. ncbi End-joining repair of double-strand breaks in Drosophila melanogaster is largely DNA ligase IV independent
    Mitch McVey
    Department of Biology, SPIRE Program, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
    Genetics 168:2067-76. 2004
  10. ncbi Removal of the bloom syndrome DNA helicase extends the utility of imprecise transposon excision for making null mutations in Drosophila
    Alice Witsell
    Department of Biology, Tufts University, Medford, Massachusetts 02155, USA
    Genetics 183:1187-93. 2009

Collaborators

Detail Information

Publications14

  1. ncbi MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings
    Mitch McVey
    Department of Biology, Tufts University, 165 Packard Avenue, Medford, MA 02155, USA
    Trends Genet 24:529-38. 2008
    ..We propose a mechanistic model for MMEJ and highlight important questions for future research...
  2. ncbi Strategies for DNA interstrand crosslink repair: insights from worms, flies, frogs, and slime molds
    Mitch McVey
    Department of Biology, Tufts University, Medford, Massachusetts 02155, USA
    Environ Mol Mutagen 51:646-58. 2010
    ....
  3. ncbi Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila
    Sze Ham Chan
    Department of Biology, Tufts University, Medford, Massachusetts, United States of America
    PLoS Genet 6:e1001005. 2010
    ..Our results establish pol theta as a key protein in alternative end joining in Drosophila and suggest a potential mechanistic link between alternative end joining and interstrand crosslink repair...
  4. ncbi Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion
    Mitch McVey
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 101:15694-9. 2004
    ..This model explains how RecQ helicases can promote homologous recombination while preventing illegitimate recombination...
  5. ncbi Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions
    Amy Marie Yu
    Department of Biology, Tufts University, Medford, MA 02155, USA
    Nucleic Acids Res 38:5706-17. 2010
    ..This suggests that a single underlying mechanism could be responsible for all three repair product types. Genetic analysis indicates that SD-MMEJ is Ku70, Lig4 and Rad51-independent but impaired in mus308 (POLQ) mutants...
  6. ncbi Multiple functions of Drosophila BLM helicase in maintenance of genome stability
    Mitch McVey
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Genetics 176:1979-92. 2007
    ..We also found that spontaneous mitotic crossovers are increased by several orders of magnitude in mus309 mutants. These results demonstrate that DmBlm functions in multiple cellular contexts to promote genome stability...
  7. ncbi Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila
    Ana Maria Garcia
    Department of Biology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
    Genome Biol 12:R121. 2011
    ..To address this, we used a lacZ reporter system in wild-type and several mutant strains of Drosophila melanogaster to analyze mechanisms of mutagenesis throughout their lifespan...
  8. ncbi Super-sized deletions: improved transposon excision screens using a mus309 mutant background
    Alice Witsell
    Department of Biology, Tufts University, Medford, MA, USA
    Fly (Austin) 4:137-40. 2010
    ..In addition, we discuss how the general principle behind this technique can be applied in other contexts where double-strand breaks are being generated for the purpose of genome modification...
  9. ncbi End-joining repair of double-strand breaks in Drosophila melanogaster is largely DNA ligase IV independent
    Mitch McVey
    Department of Biology, SPIRE Program, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
    Genetics 168:2067-76. 2004
    ..Together, our results suggest that a LIG4-independent end-joining pathway is responsible for the majority of double-strand break repair in the absence of homologous recombination in flies...
  10. ncbi Removal of the bloom syndrome DNA helicase extends the utility of imprecise transposon excision for making null mutations in Drosophila
    Alice Witsell
    Department of Biology, Tufts University, Medford, Massachusetts 02155, USA
    Genetics 183:1187-93. 2009
    ....
  11. ncbi Competition between replicative and translesion polymerases during homologous recombination repair in Drosophila
    Daniel P Kane
    Department of Biology, Tufts University, Medford, Massachusetts, USA
    PLoS Genet 8:e1002659. 2012
    ..In addition, they establish Rev1 as a crucial factor that regulates the extent of repair synthesis...
  12. ncbi In vivo analysis of Drosophila BLM helicase function during DNA double-strand gap repair
    Mitch McVey
    Department of Biology, Tufts University, Medford, MA, USA
    Methods Mol Biol 587:185-94. 2010
    ..This assay can be adapted to test the roles of numerous DNA metabolic factors in DNA double-strand gap repair...
  13. ncbi Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing
    Melissa D Adams
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Science 299:265-7. 2003
    ..These results suggest a model in which BLM maintains genomic stability by promoting efficient repair DNA synthesis and thereby prevents double-strand break repair by less precise pathways...
  14. ncbi Separation of mother and daughter cells
    Peter U Park
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Methods Enzymol 351:468-77. 2002