Nirupa R Matthan

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Approaches to measuring cholesterol absorption in humans
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer US DA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 174:197-205. 2004
  2. pmc Sex-specific differences in the predictive value of cholesterol homeostasis markers and 10-year cardiovascular disease event rate in Framingham Offspring Study participants
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Am Heart Assoc 2:e005066. 2013
  3. ncbi request reprint Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Lipid Res 44:800-6. 2003
  4. doi request reprint Effects of dietary palmitoleic acid on plasma lipoprotein profile and aortic cholesterol accumulation are similar to those of other unsaturated fatty acids in the F1B golden Syrian hamster
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:215-21. 2009
  5. pmc Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial
    Nirupa R Matthan
    Cardiovascular Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 51:202-9. 2010
  6. pmc Gender-specific differences in the kinetics of nonfasting TRL, IDL, and LDL apolipoprotein B-100 in men and premenopausal women
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:1838-43. 2008
  7. pmc Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD
    Nirupa R Matthan
    Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 50:1927-35. 2009
  8. ncbi request reprint Effect of soy protein from differently processed products on cardiovascular disease risk factors and vascular endothelial function in hypercholesterolemic subjects
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Am J Clin Nutr 85:960-6. 2007
  9. pmc Long-term fatty acid stability in human serum cholesteryl ester, triglyceride, and phospholipid fractions
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 51:2826-32. 2010
  10. ncbi request reprint A systematic review and meta-analysis of the impact of omega-3 fatty acids on selected arrhythmia outcomes in animal models
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Metabolism 54:1557-65. 2005

Detail Information

Publications36

  1. ncbi request reprint Approaches to measuring cholesterol absorption in humans
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer US DA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 174:197-205. 2004
    ..Emphasis is placed on the strengths, technical and interpretational limitations and their applicability for use in metabolic, small-scale outpatient, population and large-scale intervention studies...
  2. pmc Sex-specific differences in the predictive value of cholesterol homeostasis markers and 10-year cardiovascular disease event rate in Framingham Offspring Study participants
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Am Heart Assoc 2:e005066. 2013
    ..Available data are inconsistent regarding factors influencing plasma cholesterol homeostasis marker concentrations and their value in predicting subsequent cardiovascular disease (CVD) events...
  3. ncbi request reprint Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Lipid Res 44:800-6. 2003
    ..26, P < 0.005) and negatively associated with a percent change in beta-sitosterol (r = -0.21, P < 0.01). These data suggest that changes in stenosis were attributable, in part, to changes in cholesterol metabolism...
  4. doi request reprint Effects of dietary palmitoleic acid on plasma lipoprotein profile and aortic cholesterol accumulation are similar to those of other unsaturated fatty acids in the F1B golden Syrian hamster
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:215-21. 2009
    ..These data suggest that an oil relatively high in palmitoleic acid does not adversely affect plasma lipoprotein profiles or aortic cholesterol accumulation and was similar to other unsaturated fatty acid-rich oils...
  5. pmc Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial
    Nirupa R Matthan
    Cardiovascular Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 51:202-9. 2010
    ..The magnitude of these alterations were similar between cases and controls and do not explain differences in outcomes with pravastatin treatment...
  6. pmc Gender-specific differences in the kinetics of nonfasting TRL, IDL, and LDL apolipoprotein B-100 in men and premenopausal women
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:1838-43. 2008
    ..To investigate mechanisms underlying gender differences in serum lipoprotein concentrations, the kinetic behavior of apoB-100 was assessed...
  7. pmc Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD
    Nirupa R Matthan
    Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 50:1927-35. 2009
    ..These data suggest that impaired cholesterol homeostasis, reflected by lower synthesis and higher absorption marker concentrations, are highly significant independent predictors of prevalent CVD in this study population...
  8. ncbi request reprint Effect of soy protein from differently processed products on cardiovascular disease risk factors and vascular endothelial function in hypercholesterolemic subjects
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Am J Clin Nutr 85:960-6. 2007
    ..The magnitude of the effect of soy protein on lipoprotein concentrations is variable. This discordance is likely attributable to the various forms of soy protein used and to unrecognized shifts in dietary fatty acid, cholesterol, and fiber...
  9. pmc Long-term fatty acid stability in human serum cholesteryl ester, triglyceride, and phospholipid fractions
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 51:2826-32. 2010
    ..Thus, our data demonstrate that storage at -80 degrees C up to 10 years does not significantly influence serum CE, TG, or PL fatty acid profiles...
  10. ncbi request reprint A systematic review and meta-analysis of the impact of omega-3 fatty acids on selected arrhythmia outcomes in animal models
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Metabolism 54:1557-65. 2005
    ..It is not known whether omega-3 fatty-acid supplementation has antiarrhythmic effects in other disease settings not related to ischemia...
  11. ncbi request reprint TRL, IDL, and LDL apolipoprotein B-100 and HDL apolipoprotein A-I kinetics as a function of age and menopausal status
    Nirupa R Matthan
    Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 25:1691-6. 2005
    ..To determine mechanisms contributing to the altered lipoprotein profile associated with aging and menopause, apolipoprotein B-100 (apoB-100) and apoA-I kinetic behavior was assessed...
  12. ncbi request reprint Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston Mass 02111, USA
    Arterioscler Thromb Vasc Biol 24:1092-7. 2004
    ....
  13. pmc Substitution of vegetable oil for a partially-hydrogenated fat favorably alters cardiovascular disease risk factors in moderately hypercholesterolemic postmenopausal women
    Sonia Vega-Lopez
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
    Atherosclerosis 207:208-12. 2009
    ..Acceptable alternatives must be adjudicated. Our objective was to assess the effect of a recent commercial fat substitution, corn oil for partially-hydrogenated soybean oil...
  14. pmc Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse
    Shu Wang
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Atherosclerosis 204:147-55. 2009
    ..These data suggest that lower omega-6:EPA+DHA ratio diets lowered some measures of inflammation and Mphi cholesterol accumulation, which was associated with less aortic lesion formation in LDLr-/- mice...
  15. pmc Extended-release niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and ApoB-containing lipoproteins
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:1672-8. 2008
    ..Extended-release niacin effectively lowers plasma TG levels and raises plasma high-density lipoprotein (HDL) cholesterol levels, but the mechanisms responsible for these effects are unclear...
  16. pmc Changes in cholesterol homeostasis modify the response of F1B hamsters to dietary very long chain n-3 and n-6 polyunsaturated fatty acids
    Jaime L Lecker
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Lipids Health Dis 10:186. 2011
    ..1% cholesterol [w/w]) or cholesterol-depleted (0.01% cholesterol [w/w] and 10 days prior to killing fed 0.15% lovastatin+2% cholestyramine [w/w])...
  17. pmc Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway
    Thomas M van Himbergen
    Lipid Metabolism Laboratory, Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    Arterioscler Thromb Vasc Biol 30:113-20. 2010
    ..In light of prior metabolic and genetic research, our purpose was to ascertain whether FCH cases had significant abnormalities of plasma markers of cholesterol synthesis and absorption as compared to unaffected kindred members...
  18. pmc Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers
    Thomas M van Himbergen
    Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 50:730-9. 2009
    ..In addition, alterations in absolute values of plasma sterols correlated with the cholesterol lowering response...
  19. pmc Enhanced aortic macrophage lipid accumulation and inflammatory response in LDL receptor null mice fed an atherogenic diet
    Shu Wang
    Cardiovascular Nutrition Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Lipids 45:701-11. 2010
    ....
  20. pmc Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study
    Diane L McKay
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Nutr J 9:21. 2010
    ..A limited number of human feeding trials indicate that walnuts improve some measures of antioxidant status, but not others...
  21. pmc Altering dietary lysine:arginine ratio has little effect on cardiovascular risk factors and vascular reactivity in moderately hypercholesterolemic adults
    Sonia Vega-Lopez
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Atherosclerosis 210:555-62. 2010
    ..Information is scarce regarding the effect of dietary protein type, with specific focus on the lysine-to-arginine (Lys:Arg) ratio, on cardiovascular risk factors and vascular reactivity in humans...
  22. ncbi request reprint Novel soybean oils with different fatty acid profiles alter cardiovascular disease risk factors in moderately hyperlipidemic subjects
    Alice H Lichtenstein
    Cardiovascular Nutrition Laboratory and the Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 84:497-504. 2006
    ..A variety of soybean oils were developed with improved oxidative stability and functional characteristics for use as alternatives to partially hydrogenated fat...
  23. ncbi request reprint Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:1746-53. 2007
    ..Atorvastatin-mediated changes in cholesterol homeostasis may contribute to apoB PR regulation...
  24. pmc Impact of dietary fat type within the context of altered cholesterol homeostasis on cholesterol and lipoprotein metabolism in the F1B hamster
    Jaime L Lecker
    Cardiovascular Nutrition Laboratory, Jean Mayer US Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 59:1491-501. 2010
    ....
  25. pmc Effect of diets differing in glycemic index and glycemic load on cardiovascular risk factors: review of randomized controlled-feeding trials
    Aleksandra S Kristo
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nutrients 5:1071-80. 2013
    ..There was either weak or no effect on inflammatory markers. The results of the five randomized controlled trials satisfying the inclusion criteria suggest inconsistent effects of the GI/GL value of the diet on CVD risk factors...
  26. pmc Novel circulating fatty acid patterns and risk of cardiovascular disease: the Cardiovascular Health Study
    Fumiaki Imamura
    Department of Epidemiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 96:1252-61. 2012
    ..Complex interplays of diet and metabolism influence circulating fatty acids (FAs), possibly constituting FA patterns related to cardiovascular disease (CVD) risk...
  27. doi request reprint Tamm-Horsfall protein 1 macrophage lipid accumulation unaffected by fatty acid double-bond geometric or positional configuration
    Alice Dillard
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Nutr Res 31:625-30. 2011
    ..The cells appeared to respond similarly to the assessed fatty acids in terms of amount and type of lipid accumulated. Hence, the THP-1 cell line was not appropriate to test the hypotheses of interest...
  28. pmc In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation
    Shu Wang
    JM USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Br J Nutr 102:497-501. 2009
    ..In summary, individual long-chain PUFA have differential effects on inflammatory response and markers of cholesterol flux in MPhi which are not related to the n position of the first double bond, chain length or degree of saturation...
  29. pmc Erythrocyte stearidonic acid and other n-3 fatty acids and CHD in the Physicians' Health Study
    Chisa Matsumoto
    Division of Aging, Brigham and Women s Hospital, Boston, MA 02120, USA
    Br J Nutr 109:2044-9. 2013
    ..In conclusion, the present data did not show an association among erythrocyte SDA, ALA or marine n-3 fatty acids and the risk of CHD in male physicians...
  30. doi request reprint Docosahexaenoic acid suppresses apolipoprotein A-I gene expression through hepatocyte nuclear factor-3β
    Yu Lin Kuang
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 94:594-600. 2011
    ..The underlying mechanism responsible for this effect is not fully understood...
  31. pmc Red blood cell MUFAs and risk of coronary artery disease in the Physicians' Health Study
    Chisa Matsumoto
    Divisions of Aging and Preventive Medicine, Brigham and Women s Hospital, Boston, MA
    Am J Clin Nutr 98:749-54. 2013
    ..However, these findings remain inconsistent because some experimental studies have suggested atherogenic and lipotoxicity effects of long-chain and very-long-chain MUFAs on cardiomyocytes...
  32. pmc Red blood cell membrane concentration of cis-palmitoleic and cis-vaccenic acids and risk of coronary heart disease
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 110:539-44. 2012
    ..69 to 0.91, per SD increase). In conclusion, our data showed a positive association between RBC membrane cis-palmitoleic acid and CHD risk in male physicians. Furthermore, RBC membrane cis-vaccenic acid was inversely related to CHD...
  33. pmc Use of hamster as a model to study diet-induced atherosclerosis
    Alice Dillard
    Cardiovascular Nutrition Laboratory, Jean Mayer U, S, Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab (Lond) 7:89. 2010
    ..In conclusion, at this time the Golden-Syrian hamster does not appear to be a useful model to determine the mechanism(s) of diet-induced development of atherosclerotic lesions...
  34. doi request reprint Walnut extract inhibits LPS-induced activation of BV-2 microglia via internalization of TLR4: possible involvement of phospholipase D2
    LAUREN M WILLIS
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Inflammation 33:325-33. 2010
    ..These studies represent the first to describe the anti-inflammatory effects of walnuts in microglia, which could lead to nutritional interventions in the prevention and treatment of neurodegeneration...
  35. ncbi request reprint The effect of soybean-based foods on plasma lipid and lipoprotein concentrations
    Alice H Lichtenstein
    Am J Clin Nutr 86:1253; author reply 1253-4. 2007
  36. ncbi request reprint Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD
    Arja T Erkkilä
    School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
    J Lipid Res 47:2814-9. 2006
    ..Consistent with higher reported fish intake, higher levels of plasma TG and PL DHA are associated with less progression of coronary atherosclerosis in postmenopausal women with CAD...