Joel B Mason

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Genetic and epigenetic interactions between folate and aging in carcinogenesis
    Hyeran Jang
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 135:2967S-2971S. 2005
  2. ncbi request reprint Effects of alcohol on folate metabolism: implications for carcinogenesis
    Joel B Mason
    Vitamins and Carcinogenesis Laboratory, U S D A Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Alcohol 35:235-41. 2005
  3. pmc Folate, cancer risk, and the Greek god, Proteus: a tale of two chameleons
    Joel B Mason
    USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Nutr Rev 67:206-12. 2009
  4. ncbi request reprint A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis
    Joel B Mason
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Cancer Epidemiol Biomarkers Prev 16:1325-9. 2007
  5. doi request reprint Unraveling the complex relationship between folate and cancer risk
    Joel B Mason
    Tufts University, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Biofactors 37:253-60. 2011
  6. ncbi request reprint Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon
    Mary K Keyes
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02478, USA
    J Nutr 137:1713-7. 2007
  7. pmc Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon
    Julia Sauer
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Br J Nutr 104:24-30. 2010
  8. ncbi request reprint Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon
    Zhenhua Liu
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 137:2701-8. 2007
  9. pmc Combined inadequacies of multiple B vitamins amplify colonic Wnt signaling and promote intestinal tumorigenesis in BAT-LacZxApc1638N mice
    Zhenhua Liu
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    FASEB J 25:3136-45. 2011
  10. pmc Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines
    Jimmy W Crott
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 19:328-35. 2008

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Genetic and epigenetic interactions between folate and aging in carcinogenesis
    Hyeran Jang
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 135:2967S-2971S. 2005
    ..However, folate supplementation appears to reverse these adverse effects of aging, which is potentially of substantial import because the latter is an unmodifiable risk factor...
  2. ncbi request reprint Effects of alcohol on folate metabolism: implications for carcinogenesis
    Joel B Mason
    Vitamins and Carcinogenesis Laboratory, U S D A Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Alcohol 35:235-41. 2005
    ....
  3. pmc Folate, cancer risk, and the Greek god, Proteus: a tale of two chameleons
    Joel B Mason
    USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Nutr Rev 67:206-12. 2009
    ..Our limited understanding of this complex relationship is impeding efforts to move ahead with widespread folic acid fortification, but this delay may be necessary to ensure that such programs are instituted in a safe manner...
  4. ncbi request reprint A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis
    Joel B Mason
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Cancer Epidemiol Biomarkers Prev 16:1325-9. 2007
    ..Further work is needed to definitively establish the nature of this relationship. In the meantime, deliberations about the institution or enhancement of fortification programs should be undertaken with these considerations in mind...
  5. doi request reprint Unraveling the complex relationship between folate and cancer risk
    Joel B Mason
    Tufts University, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Biofactors 37:253-60. 2011
    ....
  6. ncbi request reprint Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon
    Mary K Keyes
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02478, USA
    J Nutr 137:1713-7. 2007
    ..041), but not in the folate-deplete group. In conclusion, aging decreases genomic DNA methylation and increases promoter methylation and expression of p16 in mouse colons. This effect is dependent on the level of dietary folate...
  7. pmc Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon
    Julia Sauer
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Br J Nutr 104:24-30. 2010
    ....
  8. ncbi request reprint Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon
    Zhenhua Liu
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 137:2701-8. 2007
    ....
  9. pmc Combined inadequacies of multiple B vitamins amplify colonic Wnt signaling and promote intestinal tumorigenesis in BAT-LacZxApc1638N mice
    Zhenhua Liu
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    FASEB J 25:3136-45. 2011
    ..05). In summary, mild depletion of multiple B vitamins produces in vivo activation of colonic Wnt signaling, implicating it as a key pathway by which B-vitamin inadequacies enhance intestinal tumorigenesis...
  10. pmc Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines
    Jimmy W Crott
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 19:328-35. 2008
    ..Folate-depletion-induced changes in the Wnt/APC pathway as well as in genes involved in cell adhesion, migration and invasion may underlie observed relationships between folate status and cancer risk...
  11. ncbi request reprint Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:1206-12. 2003
    ..However, folate supplementation is as effective at sustaining adequate colonic folate status in elder rats as it is in the young...
  12. ncbi request reprint Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston MA 02111, USA
    J Nutr 134:750-5. 2004
    ..05). This vitamin B-12-deficient diet, which was of insufficient severity to cause anemia or illness, created aberrations in both base substitution and methylation of colonic DNA, which might increase susceptibility to carcinogenesis...
  13. pmc Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer
    Zhenhua Liu
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 23:1207-13. 2012
    ..Thus, these observations offer evidence for a biologically plausible avenue, the Wnt pathway, by which obesity increases the risk of colorectal cancer...
  14. pmc Maternal B vitamin supplementation from preconception through weaning suppresses intestinal tumorigenesis in Apc1638N mouse offspring
    Eric D Ciappio
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Gut 60:1695-702. 2011
    ..This study sought to determine the effect of altering folate (and related B vitamin) availability during in-utero development and the suckling period on intestinal tumorigenesis...
  15. pmc Dietary vitamin B6 intake modulates colonic inflammation in the IL10-/- model of inflammatory bowel disease
    Jacob Selhub
    Vitamin Metabolism, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA
    J Nutr Biochem 24:2138-43. 2013
    ..Although B6 is required in dozens of reactions, its role in the breakdown of S1P may explain the biphasic relationship observed between PLP and inflammation. ..
  16. ncbi request reprint Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults
    Helen E Gabriel
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Clin Nutr 83:835-41. 2006
    ..Because folate is instrumental in DNA synthesis and repair, it is a determinant of genetic stability and therefore might attenuate the genotoxic effects of smoking...
  17. pmc Multiple B-vitamin inadequacy amplifies alterations induced by folate depletion in p53 expression and its downstream effector MDM2
    Zhenhua Liu
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Int J Cancer 123:519-25. 2008
    ....
  18. ncbi request reprint Folate supplementation increases genomic DNA methylation in the liver of elder rats
    SANG WOON CHOI
    US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Br J Nutr 93:31-5. 2005
    ..48, P=0.004). In the liver of this animal model, dietary folate over a wide range of intakes modulates genomic DNA methylation...
  19. pmc Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population
    Aurelie Chanson
    Jean Mayer US Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 89:1927-36. 2009
    ..Because of their metabolic function, folate and other one-carbon micronutrients may be important factors in the control of uracil misincorporation...
  20. doi request reprint Maternal one-carbon nutrient intake and cancer risk in offspring
    Eric D Ciappio
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Nutr Rev 69:561-71. 2011
    ....
  21. ncbi request reprint A comparison of carotenoids, retinoids, and tocopherols in the serum and buccal mucosa of chronic cigarette smokers versus nonsmokers
    Helen E Gabriel
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cancer Epidemiol Biomarkers Prev 15:993-9. 2006
    ..Such effects may be important because these nutrients, as well as retinoids, are putative chemoprotective agents...
  22. pmc Too much folate: a risk factor for cancer and cardiovascular disease?
    Julia Sauer
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Clin Nutr Metab Care 12:30-6. 2009
    ..The intent of this evidence-based review is to analyze the role of folate in chronic diseases, focusing on cancer and cardiovascular disease...
  23. ncbi request reprint Accumulation of mitochondrial DNA deletions is age, tissue and folate-dependent in rats
    Jimmy W Crott
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 3117, USA
    Mutat Res 570:63-70. 2005
    ..Furthermore, in contrast to previous work, we report that the common 4.8 kb deletion was not modulated by age, but is reduced by folate supplementation in the liver of rats...
  24. ncbi request reprint Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis
    Jimmy W Crott
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Carcinogenesis 25:69-76. 2004
    ....
  25. ncbi request reprint Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism
    Joel B Mason
    Tufts University, Boston, MA 02111, USA
    J Nutr 133:941S-947S. 2003
    ..Plasma or tissue concentrations of S-adenosylmethionine and S-adenosylhomocysteine, and genomic DNA methylation are two potential candidates in this regard although much work is yet to be done to define the nature of these relationships...
  26. ncbi request reprint Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras
    Alexander J Byun
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Cancer Lett 347:191-5. 2014
    ..Despite the apparent lack of invasion, the geographical correctness, complete penetrance and intermediate tumor burden make this model a promising addition to our toolkit for the study of colorectal cancer treatment and prevention. ..
  27. ncbi request reprint Folate depletion in human lymphocytes up-regulates p53 expression despite marked induction of strand breaks in exons 5-8 of the gene
    Jimmy W Crott
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, United States
    Mutat Res 626:171-9. 2007
    ..The induction of p53 strand breaks by folate depletion does not impair p53 expression or action within all human cell lines...
  28. pmc A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 99:5606-11. 2002
    ..03) that is known to be solely represented in those individuals. These results indicate that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status...
  29. ncbi request reprint Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins
    Haifa Ghandour
    Vitamin Metabolism, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:1357-60. 2002
    ..568). The importance of these observations is discussed...
  30. ncbi request reprint Folate status: effects on pathways of colorectal carcinogenesis
    SANG WOON CHOI
    Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:2413S-2418S. 2002
    ....
  31. ncbi request reprint Vitamin E supplementation does not alter azoxymethane-induced colonic aberrant crypt foci formation in young or old mice
    Heekyung Chung
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:528-32. 2003
    ..Whether vitamin E supplementation might be effective in reducing AOM-induced colon tumors is unclear...
  32. ncbi request reprint Nutritional chemoprevention of colon cancer
    Joel B Mason
    Department of Internal Medicine, Tufts University School of Medicine, Boston, MA, USA
    Semin Gastrointest Dis 13:143-53. 2002
    ....
  33. ncbi request reprint Severe folate deficiency impairs natural killer cell-mediated cytotoxicity in rats
    Young In Kim
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Nutr 132:1361-7. 2002
    ..These data collectively suggest that NK-mediated cytotoxicity is not a likely mechanism by which folate status modulates carcinogenesis...
  34. ncbi request reprint The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon
    Kyoung Jin Sohn
    Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada
    Carcinogenesis 24:81-90. 2003
    ..This implies that neither genomic or p53 hypomethylation within exons 6-7 nor aberrant p53 methylation within the promoter region is likely a mechanism by which folate deficiency enhances colorectal carcinogenesis in the rat...
  35. ncbi request reprint Relationship of aging and tobacco use with the development of aberrant crypt foci in a predominantly African-American population
    Darran Moxon
    Department of Medicine, University of Illinois at Chicago and Chicago Veterans Administration Medical Center, Chicago, Illinois 60612, USA
    Clin Gastroenterol Hepatol 3:271-8. 2005
    ..We hypothesized that folate depletion is linked to ACF formation and therefore studied the association between tissue folate, dietary habits, and ACF number in patients undergoing screening colonoscopy...
  36. ncbi request reprint Folic acid and vitamin B-12 supplementation does not favorably influence uracil incorporation and promoter methylation in rectal mucosa DNA of subjects with previous colorectal adenomas
    Maureen van den Donk
    Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    J Nutr 137:2114-20. 2007
    ..Because such alterations may potentially increase the risk of neoplastic transformation, more research is needed to fully define the consequences of these molecular alterations...
  37. pmc Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations
    Lauren DeVos
    Eberly College of Science, Pennsylvania State University, University Park, PA, USA
    Am J Clin Nutr 88:1149-58. 2008
    ..Folate status is also inversely related to plasma homocysteine concentrations -- a risk factor for cardiovascular disease...
  38. ncbi request reprint DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia
    Allen S Yang
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:5495-503. 2006
    ..In conclusion, we show dose-dependent hypomethylation after decitabine at low doses. Increasing the dose, which has been shown previously to result in a reduced response rate, was not accompanied by further hypomethylation...