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Genomes and Genes | Joel B MasonSummaryAffiliation: Tufts University Country: USA Publications
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Publications
Genetic and epigenetic interactions between folate and aging in carcinogenesisHyeran Jang
Vitamins and Carcinogenesis Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 135:2967S-2971S. 2005..However, folate supplementation appears to reverse these adverse effects of aging, which is potentially of substantial import because the latter is an unmodifiable risk factor...
Folate, cancer risk, and the Greek god, Proteus: a tale of two chameleonsJoel B Mason
USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Nutr Rev 67:206-12. 2009..Our limited understanding of this complex relationship is impeding efforts to move ahead with widespread folic acid fortification, but this delay may be necessary to ensure that such programs are instituted in a safe manner...- Effects of alcohol on folate metabolism: implications for carcinogenesisJoel B Mason
Vitamins and Carcinogenesis Laboratory, U S D A Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Alcohol 35:235-41. 2005.... - A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesisJoel B Mason
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Cancer Epidemiol Biomarkers Prev 16:1325-9. 2007..Further work is needed to definitively establish the nature of this relationship. In the meantime, deliberations about the institution or enhancement of fortification programs should be undertaken with these considerations in mind... 
Unraveling the complex relationship between folate and cancer riskJoel B Mason
Tufts University, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
Biofactors 37:253-60. 2011....- Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colonMary K Keyes
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02478, USA
J Nutr 137:1713-7. 2007..041), but not in the folate-deplete group. In conclusion, aging decreases genomic DNA methylation and increases promoter methylation and expression of p16 in mouse colons. This effect is dependent on the level of dietary folate... - Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colonZhenhua Liu
Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr 137:2701-8. 2007.... - Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colonJulia Sauer
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
Br J Nutr 104:24-30. 2010.... - Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell linesJimmy W Crott
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr Biochem 19:328-35. 2008..Folate-depletion-induced changes in the Wnt/APC pathway as well as in genes involved in cell adhesion, migration and invasion may underlie observed relationships between folate status and cancer risk... - Combined inadequacies of multiple B vitamins amplify colonic Wnt signaling and promote intestinal tumorigenesis in BAT-LacZxApc1638N miceZhenhua Liu
Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
FASEB J 25:3136-45. 2011..05). In summary, mild depletion of multiple B vitamins produces in vivo activation of colonic Wnt signaling, implicating it as a key pathway by which B-vitamin inadequacies enhance intestinal tumorigenesis... - Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epitheliumSANG WOON CHOI
Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston MA 02111, USA
J Nutr 134:750-5. 2004..05). This vitamin B-12-deficient diet, which was of insufficient severity to cause anemia or illness, created aberrations in both base substitution and methylation of colonic DNA, which might increase susceptibility to carcinogenesis... - Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specificSANG WOON CHOI
Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Nutr 133:1206-12. 2003..However, folate supplementation is as effective at sustaining adequate colonic folate status in elder rats as it is in the young... - Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adultsHelen E Gabriel
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Am J Clin Nutr 83:835-41. 2006..However, the cytologic damage that is evident in the mouths of smokers does not correlate with oral folate status... - Multiple B-vitamin inadequacy amplifies alterations induced by folate depletion in p53 expression and its downstream effector MDM2Zhenhua Liu
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Int J Cancer 123:519-25. 2008.... - Folate supplementation increases genomic DNA methylation in the liver of elder ratsSANG WOON CHOI
US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Br J Nutr 93:31-5. 2005..48, P=0.004). In the liver of this animal model, dietary folate over a wide range of intakes modulates genomic DNA methylation... - Maternal B vitamin supplementation from preconception through weaning suppresses intestinal tumorigenesis in Apc1638N mouse offspringEric D Ciappio
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Gut 60:1695-702. 2011..This study sought to determine the effect of altering folate (and related B vitamin) availability during in-utero development and the suckling period on intestinal tumorigenesis... - Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican populationAurelie Chanson
Jean Mayer US Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 89:1927-36. 2009..Because of their metabolic function, folate and other one-carbon micronutrients may be important factors in the control of uracil misincorporation... - Maternal one-carbon nutrient intake and cancer risk in offspringEric D Ciappio
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Nutr Rev 69:561-71. 2011.... - Accumulation of mitochondrial DNA deletions is age, tissue and folate-dependent in ratsJimmy W Crott
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 3117, USA
Mutat Res 570:63-70. 2005..Furthermore, in contrast to previous work, we report that the common 4.8 kb deletion was not modulated by age, but is reduced by folate supplementation in the liver of rats... - Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesisJimmy W Crott
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Carcinogenesis 25:69-76. 2004.... - A comparison of carotenoids, retinoids, and tocopherols in the serum and buccal mucosa of chronic cigarette smokers versus nonsmokersHelen E Gabriel
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Cancer Epidemiol Biomarkers Prev 15:993-9. 2006..Such effects may be important because these nutrients, as well as retinoids, are putative chemoprotective agents... - Too much folate: a risk factor for cancer and cardiovascular disease?Julia Sauer
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
Curr Opin Clin Nutr Metab Care 12:30-6. 2009..The intent of this evidence-based review is to analyze the role of folate in chronic diseases, focusing on cancer and cardiovascular disease... - Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolismJoel B Mason
Tufts University, Boston, MA 02111, USA
J Nutr 133:941S-947S. 2003..Plasma or tissue concentrations of S-adenosylmethionine and S-adenosylhomocysteine, and genomic DNA methylation are two potential candidates in this regard although much work is yet to be done to define the nature of these relationships... - Folate depletion in human lymphocytes up-regulates p53 expression despite marked induction of strand breaks in exons 5-8 of the geneJimmy W Crott
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, United States
Mutat Res 626:171-9. 2007..The induction of p53 strand breaks by folate depletion does not impair p53 expression or action within all human cell lines... - Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancerZhenhua Liu
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr Biochem 23:1207-13. 2012..Thus, these observations offer evidence for a biologically plausible avenue, the Wnt pathway, by which obesity increases the risk of colorectal cancer... - A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate statusSimonetta Friso
Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 99:5606-11. 2002..03) that is known to be solely represented in those individuals. These results indicate that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status... - Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteinsHaifa Ghandour
Vitamin Metabolism, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr 132:1357-60. 2002..568). The importance of these observations is discussed... - Folate status: effects on pathways of colorectal carcinogenesisSang-Woon Choi
Vitamin Metabolism Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr 132:2413S-2418S. 2002.... - Vitamin E supplementation does not alter azoxymethane-induced colonic aberrant crypt foci formation in young or old miceHeekyung Chung
Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Nutr 133:528-32. 2003..Whether vitamin E supplementation might be effective in reducing AOM-induced colon tumors is unclear... - Nutritional chemoprevention of colon cancerJoel B Mason
Department of Internal Medicine, Tufts University School of Medicine, Boston, MA, USA
Semin Gastrointest Dis 13:143-53. 2002.... - Folic acid and vitamin B-12 supplementation does not favorably influence uracil incorporation and promoter methylation in rectal mucosa DNA of subjects with previous colorectal adenomasMaureen van den Donk
Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
J Nutr 137:2114-20. 2007..Because such alterations may potentially increase the risk of neoplastic transformation, more research is needed to fully define the consequences of these molecular alterations... - Severe folate deficiency impairs natural killer cell-mediated cytotoxicity in ratsYoung In Kim
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Nutr 132:1361-7. 2002..These data collectively suggest that NK-mediated cytotoxicity is not a likely mechanism by which folate status modulates carcinogenesis... - The effect of dietary folate on genomic and p53-specific DNA methylation in rat colonKyoung Jin Sohn
Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada
Carcinogenesis 24:81-90. 2003..This implies that neither genomic or p53 hypomethylation within exons 6-7 nor aberrant p53 methylation within the promoter region is likely a mechanism by which folate deficiency enhances colorectal carcinogenesis in the rat... - Relationship of aging and tobacco use with the development of aberrant crypt foci in a predominantly African-American populationDarran Moxon
Department of Medicine, University of Illinois at Chicago and Chicago Veterans Administration Medical Center, Chicago, Illinois 60612, USA
Clin Gastroenterol Hepatol 3:271-8. 2005..Folate, alcohol, and acetylsalicylic acid (ASA) use did not influence the prevalence of these lesions... - Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrationsLauren DeVos
Eberly College of Science, Pennsylvania State University, University Park, PA, USA
Am J Clin Nutr 88:1149-58. 2008..Folate status is also inversely related to plasma homocysteine concentrations -- a risk factor for cardiovascular disease... - DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemiaAllen S Yang
Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 66:5495-503. 2006..In conclusion, we show dose-dependent hypomethylation after decitabine at low doses. Increasing the dose, which has been shown previously to result in a reduced response rate, was not accompanied by further hypomethylation...