Douglas W Losordo

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix m
    Atsushi Iwakura
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circulation 113:1605-14. 2006
  2. pmc Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization
    Gangjian Qin
    Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135
    J Exp Med 203:153-63. 2006
  3. ncbi request reprint Therapeutic angiogenesis and vasculogenesis for ischemic disease. Part I: angiogenic cytokines
    Douglas W Losordo
    St Elizabeth s Medical Center, 736 Cambridge St, Boston, Mass 02135, USA
    Circulation 109:2487-91. 2004
  4. ncbi request reprint Therapeutic angiogenesis and vasculogenesis for ischemic disease: part II: cell-based therapies
    Douglas W Losordo
    St Elizabeth s Medical Center, 736 Cambridge St, Boston, Mass 02135, USA
    Circulation 109:2692-7. 2004
  5. ncbi request reprint Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia
    Douglas W Losordo
    Division of Cardiology, Tufts School of Medicine St Elizabeth s Medical Center, Boston, Mass 02135, USA
    Circulation 105:2012-8. 2002
  6. ncbi request reprint Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activity
    Masaaki Ii
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 111:1114-20. 2005
  7. ncbi request reprint Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling
    Kengo F Kusano
    Division of Cardiovascular Research, St Elizabeth Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Nat Med 11:1197-204. 2005
  8. ncbi request reprint Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction
    Hiromichi Hamada
    Division of Cardiovascular Research, St Elizabeth Medical Center of Boston, Tufts University School of Medicine, Boston, Mass, USA
    Circulation 114:2261-70. 2006
  9. pmc The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A
    Raj Kishore
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    J Clin Invest 115:1785-96. 2005
  10. ncbi request reprint Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling
    Jun Asai
    Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circulation 113:2413-24. 2006

Detail Information

Publications81

  1. ncbi request reprint Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix m
    Atsushi Iwakura
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circulation 113:1605-14. 2006
    ..We hypothesized that estradiol could augment the incorporation of bone marrow (BM)-derived EPCs into sites of ischemia-induced neovascularization, resulting in protection from ischemic injury...
  2. pmc Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization
    Gangjian Qin
    Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135
    J Exp Med 203:153-63. 2006
    ..These data indicate that functional disruption of alpha4 integrin may represent a potential angiogenic therapy for ischemic disease by increasing the available circulating supply of EPCs...
  3. ncbi request reprint Therapeutic angiogenesis and vasculogenesis for ischemic disease. Part I: angiogenic cytokines
    Douglas W Losordo
    St Elizabeth s Medical Center, 736 Cambridge St, Boston, Mass 02135, USA
    Circulation 109:2487-91. 2004
  4. ncbi request reprint Therapeutic angiogenesis and vasculogenesis for ischemic disease: part II: cell-based therapies
    Douglas W Losordo
    St Elizabeth s Medical Center, 736 Cambridge St, Boston, Mass 02135, USA
    Circulation 109:2692-7. 2004
  5. ncbi request reprint Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia
    Douglas W Losordo
    Division of Cardiology, Tufts School of Medicine St Elizabeth s Medical Center, Boston, Mass 02135, USA
    Circulation 105:2012-8. 2002
    ....
  6. ncbi request reprint Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activity
    Masaaki Ii
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 111:1114-20. 2005
    ..The possibility that EPCs could act as reservoirs of cytokines has been implied by several observations; however, a specific role for cytokine delivery has not been identified...
  7. ncbi request reprint Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling
    Kengo F Kusano
    Division of Cardiovascular Research, St Elizabeth Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Nat Med 11:1197-204. 2005
    ....
  8. ncbi request reprint Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction
    Hiromichi Hamada
    Division of Cardiovascular Research, St Elizabeth Medical Center of Boston, Tufts University School of Medicine, Boston, Mass, USA
    Circulation 114:2261-70. 2006
    ..However, the roles of estrogen receptors alpha (ER alpha) and beta (ER beta) in EPC biology are largely unknown...
  9. pmc The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A
    Raj Kishore
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    J Clin Invest 115:1785-96. 2005
    ....
  10. ncbi request reprint Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling
    Jun Asai
    Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circulation 113:2413-24. 2006
    ..Because diabetes is associated with impaired wound healing, we tested this hypothesis in a diabetic model of cutaneous wound repair...
  11. ncbi request reprint Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization
    Jun Ichi Yamaguchi
    Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 107:1322-8. 2003
    ..Given the close relationship between hematopoietic stem cells and endothelial progenitor cells (EPCs), we investigated the effect of SDF-1 on EPC-mediated vasculogenesis...
  12. ncbi request reprint Synergistic effect of bone marrow mobilization and vascular endothelial growth factor-2 gene therapy in myocardial ischemia
    Atsuhiko Kawamoto
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 110:1398-405. 2004
    ....
  13. ncbi request reprint Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization
    David A Goukassian
    Division of Cardiovascular Diseases, Department of Medicine, Caritas St Elizabeth s Medical Center, Boston, Mass, USA
    Circulation 115:752-62. 2007
    ..Little is known about the role of TNF-alpha receptors (TNFR1/p55 and TNFR2/p75) in angiogenic signaling...
  14. pmc Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing
    Kazuichi Maruyama
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Am J Pathol 170:1178-91. 2007
    ..These observations suggest a potential therapeutic approach for healing wounds in diabetic patients...
  15. ncbi request reprint Enhanced voluntary alcohol consumption after estrogen supplementation negates estrogen-mediated vascular repair in ovariectomized mice
    Johnson Rajasingh
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Endocrinology 148:3618-24. 2007
    ....
  16. ncbi request reprint Synergistic effect of combined intramyocardial CD34+ cells and VEGF2 gene therapy after MI
    Satoshi Shintani
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Nat Clin Pract Cardiovasc Med 3:S123-8. 2006
    ..This approach may overcome therapeutic failures (e.g. inability of certain patients to mobilize sufficient EPCs) and may also offer safety advantages by allowing lower dosing strategies...
  17. ncbi request reprint Long-term stable expression of human growth hormone by rAAV promotes myocardial protection post-myocardial infarction
    Kengo Kusano
    Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge St, Boston, MA 02135, USA
    J Mol Cell Cardiol 42:390-9. 2007
    ....
  18. ncbi request reprint Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury
    Atsushi Iwakura
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 108:3115-21. 2003
    ..We hypothesized that estrogen-induced acceleration of reendothelialization might be mediated in part by effects involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells (EPCs)...
  19. ncbi request reprint IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression
    Johnson Rajasingh
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    FASEB J 20:2112-4. 2006
    ....
  20. ncbi request reprint Engineering the response to vascular injury: divergent effects of deregulated E2F1 expression on vascular smooth muscle cells and endothelial cells result in endothelial recovery and inhibition of neointimal growth
    David A Goukassian
    Department of Medicine, Division of Cardiovascular Research, St Elizabeth s Medical Center, Boston, Mass, USA
    Circ Res 93:162-9. 2003
    ....
  21. pmc Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction
    Young Sup Yoon
    Division of Cardiovascular Medicine, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    J Clin Invest 115:326-38. 2005
    ..To our knowledge, this is the first demonstration that a specific population of multipotent human BM-derived stem cells can induce both therapeutic neovascularization and endogenous and exogenous cardiomyogenesis...
  22. ncbi request reprint Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia
    Roberto Pola
    Department of Medicine Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135 2997, USA
    Circulation 108:479-85. 2003
    ..Here, we studied whether the endogenous Hh pathway, in addition to its functions during embryogenesis, plays a physiological role in muscle regeneration after ischemia in adults...
  23. ncbi request reprint Hyperhomocyst(e)inemia impairs angiogenesis in a murine model of limb ischemia
    Marta Bosch-Marce
    Department of Medicine Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135 2997, USA
    Vasc Med 10:15-22. 2005
    ..In contrast, our data suggest that impaired Akt phosphorylation mediates the impairment of angiogenesis associated with HH...
  24. ncbi request reprint Endothelial progenitor thrombospondin-1 mediates diabetes-induced delay in reendothelialization following arterial injury
    Masaaki Ii
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circ Res 98:697-704. 2006
    ....
  25. ncbi request reprint CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after myocardial infarction compared with total mononuclear cells
    Atsuhiko Kawamoto
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 114:2163-9. 2006
    ..We compared the therapeutic potential of purified mobilized human CD34+ cells with that of mobilized total mononuclear cells (tMNCs) for the preservation/recovery of myocardial tissue integrity and function after myocardial infarction (MI)...
  26. ncbi request reprint Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF
    Rudolf Kirchmair
    Department of Cardiovascular Research, St Elizabeth s Medical Center Tufts University School of Medicine, Boston, Massachusetts, USA
    Mol Ther 15:69-75. 2007
    ..These findings implicate microvascular damage as the basis for toxic neuropathy and suggest that angiogenic growth factors may constitute a novel treatment for this disorder...
  27. ncbi request reprint Tumor necrosis factor-mediated E2F1 suppression in endothelial cells: differential requirement of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signal transduction pathways
    Raj Kishore
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circ Res 93:932-40. 2003
    ..Targeted inactivation of JNK1 at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF-mediated EC dysfunction...
  28. pmc Myocardial knockdown of mRNA-stabilizing protein HuR attenuates post-MI inflammatory response and left ventricular dysfunction in IL-10-null mice
    Prasanna Krishnamurthy
    Feinberg Cardiovascular Research Institute, Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    FASEB J 24:2484-94. 2010
    ..Taken together, our studies suggest that HuR is a direct target of IL-10, and HuR knockdown mimics anti-inflammatory effects of IL-10...
  29. pmc Critical role of endothelial Notch1 signaling in postnatal angiogenesis
    Kyosuke Takeshita
    Vascular Medicine Research Unit, Brigham and Women s Hospital, Boston, MA, USA
    Circ Res 100:70-8. 2007
    ..These results suggest that Notch1 may be a novel therapeutic target for improving angiogenic response and blood flow recovery in ischemic limbs...
  30. ncbi request reprint Determination of bone marrow-derived endothelial progenitor cell significance in angiogenic growth factor-induced neovascularization in vivo
    Toshinori Murayama
    Division of Cardiovascular Research, Department of Medicine, St Elizabeth s Medical Center of Boston, Tufts University School of Medicine, Brighton, Mass 02135 2997, USA
    Exp Hematol 30:967-72. 2002
    ..To address this issue, we investigated the quantitative contribution of EPCs to newly formed vascular structures in an in vivo Matrigel plug assay and corneal micropocket assay...
  31. pmc Intramyocardial, autologous CD34+ cell therapy for refractory angina
    Douglas W Losordo
    Division of Cardiology, Northwestern Memorial Hospital, Northwestern University, Chicago, IL 60611, USA
    Circ Res 109:428-36. 2011
    ..A growing number of patients with coronary disease have refractory angina. Preclinical and early-phase clinical data suggest that intramyocardial injection of autologous CD34+ cells can improve myocardial perfusion and function...
  32. ncbi request reprint Neuronal nitric oxide synthase mediates statin-induced restoration of vasa nervorum and reversal of diabetic neuropathy
    Masaaki Ii
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge St, Boston, MA 02135, USA
    Circulation 112:93-102. 2005
    ..Peripheral neuropathy is a frequent and major complication of diabetes...
  33. ncbi request reprint Local gene transfer of phVEGF-2 plasmid by gene-eluting stents: an alternative strategy for inhibition of restenosis
    Dirk H Walter
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 110:36-45. 2004
    ....
  34. pmc Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF
    Gangjian Qin
    Division of Cardiovascular Research, Tufts University School of Medicine, Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    Proc Natl Acad Sci U S A 103:11015-20. 2006
    ..These data disclose an unexpected function of endogenous E2F1: regulation of angiogenic activity via p53-dependent transcriptional control of VEGF expression...
  35. ncbi request reprint Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth
    Rudolf Kirchmair
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 111:2662-70. 2005
    ..The pathogenic basis for toxic neuropathies induced by chemotherapeutic agents has not been completely elucidated...
  36. ncbi request reprint Magnetic resonance mapping of transplanted endothelial progenitor cells for therapeutic neovascularization in ischemic heart disease
    Alberto Weber
    Divisions of Cardiovascular Research and Cardiovascular Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Eur J Cardiothorac Surg 26:137-43. 2004
    ..We present a novel technique using magnetic resonance imaging (MRI) to localize transplanted EPCs in ischemic hearts...
  37. ncbi request reprint Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of
    Young Sup Yoon
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 111:2073-85. 2005
    ..Diabetic cardiomyopathy (DCM) is characterized by microvascular pathology and interstitial fibrosis, which leads to progressive heart failure; however, the pathogenesis of DCM remains uncertain...
  38. pmc VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema
    Young Sup Yoon
    Department of Vascular Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Clin Invest 111:717-25. 2003
    ..This novel therapeutic strategy may merit clinical investigation in patients with lymphedema...
  39. ncbi request reprint Use of recombinant adeno-associated viral vectors as a tool for labeling bone marrow cells
    Atsushi Iwakura
    Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA
    J Mol Cell Cardiol 38:799-802. 2005
    ..rAAV vectors programmed stable transduction in BM cells in vivo through rapid infection. rAAV appears to represent a useful vector for labeling BM cells ex vivo prior to BMT for analysis of cardiovascular therapeutic purposes...
  40. ncbi request reprint Ethanol modulation of TNF-alpha biosynthesis and signaling in endothelial cells: synergistic augmentation of TNF-alpha mediated endothelial cell dysfunctions by chronic ethanol
    Corinne Luedemann
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Alcohol Clin Exp Res 29:930-8. 2005
    ..Taken together, these data indicate that chronic ethanol consumption may negatively influence post angioplasty re-endothelialization thereby contributing to the development of restenosis...
  41. ncbi request reprint Age-dependent VEGF expression and intraneural neovascularization during regeneration of peripheral nerves
    Roberto Pola
    Department of Medicine Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Neurobiol Aging 25:1361-8. 2004
    ....
  42. ncbi request reprint Transcutaneous ultrasound augments naked DNA transfection of skeletal muscle
    Peter Schratzberger
    Department of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Mol Ther 6:576-83. 2002
    ..The biological significance of this finding was confirmed by augmented limb perfusion in response to US exposure and naked VEGF DNA...
  43. ncbi request reprint Therapeutic myocardial angiogenesis with vascular endothelial growth factors
    Young Sup Yoon
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    Mol Cell Biochem 264:63-74. 2004
    ....
  44. ncbi request reprint Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy
    Kengo F Kusano
    Division of Cardiovascular Research, St Elizabeth Medical Center Boston, Boston, MA 02135, USA
    Arterioscler Thromb Vasc Biol 24:2102-7. 2004
    ..Accordingly, we investigated the hypothesis that systemic injection of SHh protein could improve nerve blood flow and function in diabetic neuropathy (DN)...
  45. ncbi request reprint Functional ephrin-B2 expression for promotive interaction between arterial and venous vessels in postnatal neovascularization
    Shin Ichiro Hayashi
    Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 111:2210-8. 2005
    ..In this study, we focused on the function of ephrin-B2 in postnatal neovascularization...
  46. ncbi request reprint Transplantation of endothelial progenitor cells for therapeutic neovascularization
    Atsuhiko Kawamoto
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA, USA
    Cardiovasc Radiat Med 3:221-5. 2002
    ..Further basic research, with improved understanding of the mechanisms governing homing and incorporation of EPCs, will be still necessary to optimize the methodology of the cell therapy...
  47. ncbi request reprint Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia
    Atsuhiko Kawamoto
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 107:461-8. 2003
    ..We investigated whether catheter-based, intramyocardial transplantation of autologous endothelial progenitor cells can enhance neovascularization in myocardial ischemia...
  48. ncbi request reprint Non-viral vectors for gene therapy: clinical trials in cardiovascular disease
    Pinak B Shah
    Division of Cardiology, Caritas St Elizabeth s Medical Center Boston, Massachusetts 02135, USA
    Adv Genet 54:339-61. 2005
    ..This chapter will describe the clinical trial experience to date with delivery of non-viral gene therapy for therapeutic angiogenesis in humans with disabling myocardial ischemia and peripheral vascular disease...
  49. ncbi request reprint Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells
    Satoshi Murasawa
    Department of Medicine Vascular Medicine, Cardiology, Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 106:1133-9. 2002
    ....
  50. pmc Cell therapy of peripheral arterial disease: from experimental findings to clinical trials
    Zankhana Raval
    Department of Medicine, Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Circ Res 112:1288-302. 2013
    ..Here, we review the current state of that field...
  51. ncbi request reprint Derivation and characterization of bone marrow-derived multipotent stem cells
    Jiyoon Lee
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Exp Hematol 34:1602-3. 2006
  52. ncbi request reprint Divergence of angiogenic and vascular permeability signaling by VEGF: inhibition of protein kinase C suppresses VEGF-induced angiogenesis, but promotes VEGF-induced, NO-dependent vascular permeability
    Ioakim Spyridopoulos
    Department of Cardiovascular Research, St Elizabeth s Medical Center, Boston, Mass 02135, USA
    Arterioscler Thromb Vasc Biol 22:901-6. 2002
    ..These results reveal that angiogenesis and vascular permeability induced by VEGF are mediated by mechanisms which ultimately diverge...
  53. ncbi request reprint Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells
    Dirk H Walter
    Department of Medicine Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 105:3017-24. 2002
    ..Primary and secondary prevention trials suggest that statins possess favorable effects independent of cholesterol reduction. We investigated whether statin therapy may also accelerate reendothelialization after carotid balloon injury...
  54. ncbi request reprint Transplant graft vasculopathy: a dark side of bone marrow stem cells?
    Masaaki Ii
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, University, School of Medicine, Boston, Mass 02135, USA
    Circulation 108:3056-8. 2003
  55. pmc Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages
    Kazuichi Maruyama
    Ocular Immunology Group, The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 115:2363-72. 2005
    ..The novel finding that CD11b+ macrophages are critical for the development of inflammation-dependent lymphangiogenesis in the eye suggests a new mechanism of lymphangiogenesis...
  56. ncbi request reprint Functionally novel tumor necrosis factor-alpha-modulated CHR-binding protein mediates cyclin A transcriptional repression in vascular endothelial cells
    Raj Kishore
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circ Res 91:307-14. 2002
    ..Additionally, exposure of ECs to TNF-alpha markedly reduced cyclin A mRNA stability. Targeted disruption of this protein could potentially be a therapeutic strategy to rescue EC proliferation in vivo...
  57. ncbi request reprint Topical application of ex vivo expanded endothelial progenitor cells promotes vascularisation and wound healing in diabetic mice
    Jun Asai
    Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA Department of Pharmacology, Osaka Medical College, Osaka, Japan Feinberg Cardiovascular Research Institute and Regenerative Medicine Program, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Int Wound J 10:527-33. 2013
    ..This strategy exploiting the therapeutic capacity of autologously derived EPCs may be a novel approach to skin repair in diabetes. ..
  58. ncbi request reprint Unexpected severe calcification after transplantation of bone marrow cells in acute myocardial infarction
    Young Sup Yoon
    Division of Cardiovascular Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge St, Boston, Mass 02135, USA
    Circulation 109:3154-7. 2004
    ..Thus far, no significant deleterious effects or complications have been reported in any studies using BM-derived cells for treatment of various cardiac diseases...
  59. ncbi request reprint Angiogenic gene therapy: pre-clinical studies and phase I clinical data
    Riyaz Bashir
    Tufts University School of Medicine, Boston, Massachusetts, USA
    Kidney Int 61:S110-4. 2002
    ..In general, these conditions are characterized by local hypovascularity, and the approach to treatment is therefore focused on stimulating neovascularization...
  60. ncbi request reprint Repair of ischemic heart disease with novel bone marrow-derived multipotent stem cells
    Namho Lee
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Cell Cycle 4:861-4. 2005
    ..In this review, we will discuss the currently available bone marrow-derived stem progenitor cells for myocardial repair and focus on the advantages of using recently identified novel bone marrow-derived multipotent stem cells (BMSC)...
  61. ncbi request reprint Gene therapy for restenosis: biological solution to a biological problem
    Raj Kishore
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    J Mol Cell Cardiol 42:461-8. 2007
    ..For the purpose of this review, we have focused ou discussion on two relevant anti-restenosis strategies, anti-proliferative and pro-endothelialization...
  62. doi request reprint Endothelial dysfunction and systemic hypertension by selective cGMP-dependent protein kinase I inhibition using novel cell-penetrating peptide delivered in vivo
    Kian Keong Poh
    Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge St, Boston, MA 02135, USA
    Int J Cardiol 167:2114-9. 2013
    ..We hypothesized that highly selective inhibitors of cGPK delivered in vivo in adult may elucidate the role of the kinase in vasorelaxation and regulation of blood pressure...
  63. ncbi request reprint Gene therapy for cardiovascular angiogenesis
    Larry J Diaz-Sandoval
    Divisions of Cardiovascular Medicine and Cardiovascular Research, St Elizabeth s Medical Center of Boston, Tufts University School of Medicine, 736 Cambridge St, Boston, MA 02135, USA
    Expert Opin Biol Ther 3:599-616. 2003
    ....
  64. ncbi request reprint Acetylcysteine to prevent angiography-related renal tissue injury (the APART trial)
    Larry J Diaz-Sandoval
    Division of Cardiovascular Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Am J Cardiol 89:356-8. 2002
  65. pmc Endothelial progenitor cells for cardiovascular regeneration
    Atsuhiko Kawamoto
    Vascular Regeneration Research Group, Institute of Biomedical Research and Innovation, Kobe, Japan
    Trends Cardiovasc Med 18:33-7. 2008
    ..This review summarizes the progression of basic, preclinical, and clinical research into the potential use of EPC therapy for cardiovascular regeneration...
  66. pmc Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair
    Johnson Rajasingh
    Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago IL 60611, USA
    Circ Res 102:e107-17. 2008
    ..These data provide evidence for the generation of functional multipotent stem-like cells from terminally differentiated somatic cells without the introduction of retroviral mediated transgenes or ESC fusion...
  67. doi request reprint Therapeutic angiogenesis for critical limb ischemia: microvascular therapies coming of age
    Jörn Tongers
    Circulation 118:9-16. 2008
  68. ncbi request reprint Therapeutic angiogenesis by gene transfer in critical limb and myocardial ischemia
    Peter Schratzberger
    Department of Internal Medicine, Division of General Internal Medicine, University Hospital Innsbruck, Innsbruck, Austria
    Curr Pharm Des 9:1041-7. 2003
    ..This review will discuss gene transfer strategies for therapeutic angiogenesis in critical limb and myocardial ischemia...
  69. pmc Netrins promote developmental and therapeutic angiogenesis
    Brent D Wilson
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Science 313:640-4. 2006
    ..We propose that the attractive vascular and neural guidance functions of netrins offer a unique therapeutic potential...
  70. ncbi request reprint Mending the broken heart: ischemic preconditioning-stimulated myocardial angiogenesis
    Raj Kishore
    J Mol Cell Cardiol 37:1-3. 2004
  71. pmc Therapeutic myocardial angiogenesis
    Marie Ange Renault
    Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Tarry 12 703, Chicago, IL 60611, USA
    Microvasc Res 74:159-71. 2007
    ....
  72. ncbi request reprint STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction
    Johnson Rajasingh
    Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, USA
    Circ Res 101:910-8. 2007
    ..Thus augmentation of LIF/BMP-2 downstream signaling components or cell type specific precommitment may facilitate the effects of ES cell-based therapies for post-MI myocardial repair and regeneration...
  73. ncbi request reprint Statins and the endothelium
    Masaaki Ii
    Stem Cell Translational Research, RIKEN Center for Developmental Biology, 2 2 Minatojima, Minamimachi, Kobe, Japan
    Vascul Pharmacol 46:1-9. 2007
    ..This review provides an update of the unique effects of statins on endothelial cells including endothelial progenitor cells as well as highlighting the therapeutic potential of statins beyond their established lipid-lowering effects...
  74. ncbi request reprint Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial
    Douglas W Losordo
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Feinberg School of Medicine and Northwestern Memorial Hospital, Chicago, IL 60611, USA
    Circulation 115:3165-72. 2007
    ..Preclinical studies have indicated that human CD34+ stem cells induce neovascularization in ischemic myocardium, which enhances perfusion and function...
  75. ncbi request reprint Hypoxia up-regulates the angiogenic cytokine secretoneurin via an HIF-1alpha- and basic FGF-dependent pathway in muscle cells
    Margot Egger
    Department of Internal Medicine, University of Innsbruck, Anichstr 35, 6020 Innsbruck, Austria
    FASEB J 21:2906-17. 2007
    ..In summary, our data show that the angiogenic cytokine secretoneurin is up-regulated by hypoxia in muscle cells by hypoxia-inducible factor-1alpha- and basic fibroblast growth factor-dependent mechanisms...
  76. ncbi request reprint One-year follow-up of direct myocardial gene transfer of vascular endothelial growth factor-2 using naked plasmid deoxyribonucleic acid by way of thoracotomy in no-option patients
    F David Fortuin
    Scripps Clinic, Green Hospital, La Jolla, California 92037, USA
    Am J Cardiol 92:436-9. 2003
    ..A randomized phase III trial is underway that will help determine the efficacy of vascular endothelial growth factor-2 gene transfer in "no-option" patients...
  77. ncbi request reprint The matrix revolutions: matrix metalloproteinase, vasculogenesis, and ischemic tissue repair
    Marie Ange Renault
    Circ Res 100:749-50. 2007
  78. ncbi request reprint All in the family: VEGF-B joins the ranks of proangiogenic cytokines
    Young Sup Yoon
    Circ Res 93:87-90. 2003
  79. ncbi request reprint Endothelial recovery: the next target in restenosis prevention
    Douglas W Losordo
    Circulation 107:2635-7. 2003
  80. ncbi request reprint Biological revascularization and the interventional molecular cardiologist: bypass for the next generation
    Douglas W Losordo
    Circulation 106:3002-5. 2002
  81. pmc Pulmonary gas transfer related to markers of angiogenesis during the menstrual cycle
    Samar Farha
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, Cleveland, OH, USA
    J Appl Physiol 103:1789-95. 2007
    ..These findings suggest that angiogenesis in the lungs may participate in the cyclic changes in gas transfer that occur over the menstrual cycle...