Chun Liu

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. pmc Modulation of lung molecular biomarkers by beta-carotene in the Physicians' Health Study
    Chun Liu
    Nutrition and Cancer Biology Laboratory, US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Cancer 115:1049-58. 2009
  2. ncbi request reprint Lycopene supplementation prevents smoke-induced changes in p53, p53 phosphorylation, cell proliferation, and apoptosis in the gastric mucosa of ferrets
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 136:106-11. 2006
  3. pmc β-Cryptoxanthin supplementation prevents cigarette smoke-induced lung inflammation, oxidative damage, and squamous metaplasia in ferrets
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cancer Prev Res (Phila) 4:1255-66. 2011
  4. ncbi request reprint Nutrition and gastric cancer risk: an update
    Chun Liu
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Nutr Rev 66:237-49. 2008
  5. ncbi request reprint Combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model
    Yuri Kim
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Carcinogenesis 27:1410-9. 2006
  6. pmc Combined α-tocopherol and ascorbic acid protects against smoke-induced lung squamous metaplasia in ferrets
    Yuri Kim
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Lung Cancer 75:15-23. 2012
  7. ncbi request reprint Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Cancer Res 63:3138-44. 2003
  8. pmc β-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice
    Anita R Iskandar
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Cancer Prev Res (Phila) 6:309-20. 2013
  9. ncbi request reprint Alpha-tocopherol and ascorbic acid decrease the production of beta-apo-carotenals and increase the formation of retinoids from beta-carotene in the lung tissues of cigarette smoke-exposed ferrets in vitro
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 134:426-30. 2004
  10. pmc Long-term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in rats
    Pollyanna R G Chavez
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 141:1049-55. 2011

Collaborators

Detail Information

Publications28

  1. pmc Modulation of lung molecular biomarkers by beta-carotene in the Physicians' Health Study
    Chun Liu
    Nutrition and Cancer Biology Laboratory, US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Cancer 115:1049-58. 2009
    ..The objective of the current investigation was to evaluate how long-term beta-carotene supplementation affects molecular markers of lung carcinogenesis in the PHS...
  2. ncbi request reprint Lycopene supplementation prevents smoke-induced changes in p53, p53 phosphorylation, cell proliferation, and apoptosis in the gastric mucosa of ferrets
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 136:106-11. 2006
    ..These data indicate that lycopene may prevent smoke exposure-induced changes in p53, p53 phosphorylation, p53 target genes, cell proliferation, and apoptosis in the gastric mucosa of ferrets...
  3. pmc β-Cryptoxanthin supplementation prevents cigarette smoke-induced lung inflammation, oxidative damage, and squamous metaplasia in ferrets
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cancer Prev Res (Phila) 4:1255-66. 2011
    ..Data from this study indicate that β-cryptoxanthin provides a beneficial effect against cigarette smoke-induced inflammation, oxidative DNA damage and squamous metaplasia in the lungs...
  4. ncbi request reprint Nutrition and gastric cancer risk: an update
    Chun Liu
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Nutr Rev 66:237-49. 2008
    ..However, current data provide little support for an association of beta-carotene, vitamin E, and alcohol consumption with risk for gastric cancer...
  5. ncbi request reprint Combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model
    Yuri Kim
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Carcinogenesis 27:1410-9. 2006
    ....
  6. pmc Combined α-tocopherol and ascorbic acid protects against smoke-induced lung squamous metaplasia in ferrets
    Yuri Kim
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Lung Cancer 75:15-23. 2012
    ..These data indicate that the combination of antioxidant AT+AA alone exerts protective effects against SM-induced lung lesions through inhibiting cyclin D1 expression and partially restoring retinoic acid levels to normal...
  7. ncbi request reprint Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Cancer Res 63:3138-44. 2003
    ....
  8. pmc β-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice
    Anita R Iskandar
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Cancer Prev Res (Phila) 6:309-20. 2013
    ..In addition, our study establishes a relevant animal lung cancer model for studying tumor growth within emphysematous microenvironments...
  9. ncbi request reprint Alpha-tocopherol and ascorbic acid decrease the production of beta-apo-carotenals and increase the formation of retinoids from beta-carotene in the lung tissues of cigarette smoke-exposed ferrets in vitro
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 134:426-30. 2004
    ....
  10. pmc Long-term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in rats
    Pollyanna R G Chavez
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 141:1049-55. 2011
    ..Together, these results indicate that chronic, excessive ethanol consumption impairs normal hepatocyte proliferation, which is associated with reduced IGF-1 levels, but promotes hepatic carcinogenesis...
  11. pmc Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice
    Blanche C Ip
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Room 514, Boston, MA 02111
    Cancer Prev Res (Phila) 6:1304-16. 2013
    ..Taken together, these data indicate that APO10LA can effectively inhibit HFD-promoted hepatic tumorigenesis by stimulating SIRT1 signaling while reducing hepatic inflammation...
  12. ncbi request reprint The effect of dietary glutathione and coenzyme Q10 on the prevention and treatment of inflammatory bowel disease in mice
    Chun Liu
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Int J Vitam Nutr Res 74:74-85. 2004
    ..Further studies using additional animal models are required to determine whether GSH or CoQ10 provide a favorable or unfavorable benefit:risk ratio in the prevention or treatment of IBD...
  13. pmc Phasic respiratory modulation of pharyngeal collapsibility via neuromuscular mechanisms in rats
    Ying Cao
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Appl Physiol (1985) 112:695-703. 2012
    ....
  14. ncbi request reprint Low dose beta-carotene supplementation of ferrets attenuates smoke-induced lung phosphorylation of JNK, p38 MAPK, and p53 proteins
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 134:2705-10. 2004
    ..These data provide supportive evidence that the beneficial vs. detrimental effects of beta-carotene supplementation are related to the dosage of beta-carotene administered...
  15. ncbi request reprint Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): a model for human lung cancer
    Yuri Kim
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cancer Lett 234:209-19. 2006
    ....
  16. ncbi request reprint Exposing ferrets to cigarette smoke and a pharmacological dose of beta-carotene supplementation enhance in vitro retinoic acid catabolism in lungs via induction of cytochrome P450 enzymes
    Chun Liu
    Nutrition and Cancer Biology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 133:173-9. 2003
    ....
  17. pmc Glossopharyngeal long-term facilitation requires serotonin 5-HT2 and NMDA receptors in rats
    Ying Cao
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, BLI 043B, Boston, MA 02115, USA
    Respir Physiol Neurobiol 170:164-72. 2010
    ..Hypoxic glossopharyngeal responses were minimally changed after either drug. These data suggest that AIH induces both phasic and tonic glossopharyngeal LTF, which requires activation of 5-HT(2) and NMDA receptors...
  18. pmc The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo
    Kang Quan Hu
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 281:19327-38. 2006
    ....
  19. ncbi request reprint Beta-carotene and beta-apo-14'-carotenoic acid prevent the reduction of retinoic acid receptor beta in benzo[a]pyrene-treated normal human bronchial epithelial cells
    Pankaj Prakash
    Nutrition and Cancer Biology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, School of Medicine, Tufts University, Boston, MA 02111, USA
    J Nutr 134:667-73. 2004
    ..These observations indicate that the growth inhibitory effects of BC and beta-apo-carotenoic acid are through their conversion to RA and upregulation of RARbeta...
  20. pmc Chronic alcohol intake upregulates hepatic expression of carotenoid cleavage enzymes and PPAR in rats
    Renata A M Luvizotto
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 140:1808-14. 2010
    ..This process may be due to alcohol-induced PPARγ expression and lower vitamin A status in the liver...
  21. pmc Sleep fragmentation attenuates the hypercapnic (but not hypoxic) ventilatory responses via adenosine A1 receptors in awake rats
    Chun Liu
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Respir Physiol Neurobiol 175:29-36. 2011
    ..9 ± 11.8%). Collectively, these results suggest that: (1) 24 h SF does not change isocapnic HVR but causes an attenuation of HCVR; and (2) this attenuation lasts for only a few hours and requires activation of adenosine A1 receptors...
  22. ncbi request reprint A simple HPLC method for the comprehensive analysis of cis/trans (Z/E) geometrical isomers of carotenoids for nutritional studies
    Antonio J Meléndez-Martínez
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Food Chem 138:1341-50. 2013
    ..This is to the best of our knowledge the report of the highest number of carotenoid geometrical isomers separated with a HPLC method. Twenty-six different carotenoid isomers were readily detected in the biological samples...
  23. ncbi request reprint Chlormethiazole treatment prevents reduced hepatic vitamin A levels in ethanol-fed rats
    Chun Liu
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Alcohol Clin Exp Res 26:1703-9. 2002
    ..This study investigated whether treatment with chlormethiazole, a CYP inhibitor, restores vitamin A in the livers of ethanol-fed rats...
  24. pmc Formation and maintenance of ventilatory long-term facilitation require NMDA but not non-NMDA receptors in awake rats
    Michelle McGuire
    Div of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Appl Physiol (1985) 105:942-50. 2008
    ..Collectively, these results suggest that activation of NMDA but not non-NMDA receptors is necessary for formation and maintenance of vLTF in awake rats...
  25. ncbi request reprint [Evaluation oxygen free radicals related index before liver transplantation to forejudge prognosis]
    Chun Liu
    the Third Hospital of Peking University, Beijing 100083, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15:560-2. 2003
    ..To research the relationship of oxygen free radicals related index before liver transplantation with prognosis...
  26. ncbi request reprint Effectiveness of intermittent -Gx gravitation in preventing deconditioning due to simulated microgravity
    Li Fan Zhang
    Department of Aerospace Physiology, Fourth Military Medical University, Xi an 710032, People s Republic of China
    J Appl Physiol (1985) 95:207-18. 2003
    ..The present work suggests that system specificity in responsiveness to intermittent gravity exposure should be considered one of the prerequisites in proposing intermittent artificial gravity as a potential countermeasure...
  27. ncbi request reprint Daily 4-h head-up tilt is effective in preventing muscle but not bone atrophy due to simulated microgravity
    Biao Sun
    Department of Aerospace Physiology, The Fourth Military Medical University, Xi an, China
    J Gravit Physiol 10:29-38. 2003
    ..Daily 4-h HUT, as 4-h STD, is also ineffective in attenuating adverse changes in bone mass, but seems partially effective in preventing declines in mechanical properties due to simulated microgravity...
  28. ncbi request reprint Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response
    Bernard Meshi
    UBC McDonald Research Laboratories, The iCAPTURE Center, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 26:52-7. 2002
    ..In this study, the increase in CD4 was associated with cigarette smoke and the increase in CD8 cells with latent Ad infection...