Research Topics
Genomes and Genes | Chun LiuSummaryAffiliation: Tufts University Country: USA Publications
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Publications
Modulation of lung molecular biomarkers by beta-carotene in the Physicians' Health StudyChun Liu
Nutrition and Cancer Biology Laboratory, US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Cancer 115:1049-58. 2009..The objective of the current investigation was to evaluate how long-term beta-carotene supplementation affects molecular markers of lung carcinogenesis in the PHS...
Nutrition and gastric cancer risk: an updateChun Liu
Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
Nutr Rev 66:237-49. 2008..However, current data provide little support for an association of beta-carotene, vitamin E, and alcohol consumption with risk for gastric cancer...- β-Cryptoxanthin supplementation prevents cigarette smoke-induced lung inflammation, oxidative damage, and squamous metaplasia in ferretsChun Liu
Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Cancer Prev Res (Phila) 4:1255-66. 2011..Data from this study indicate that β-cryptoxanthin provides a beneficial effect against cigarette smoke-induced inflammation, oxidative DNA damage and squamous metaplasia in the lungs... 
Lycopene supplementation prevents smoke-induced changes in p53, p53 phosphorylation, cell proliferation, and apoptosis in the gastric mucosa of ferretsChun Liu
Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Nutr 136:106-11. 2006..These data indicate that lycopene may prevent smoke exposure-induced changes in p53, p53 phosphorylation, p53 target genes, cell proliferation, and apoptosis in the gastric mucosa of ferrets...- Combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer modelYuri Kim
Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Carcinogenesis 27:1410-9. 2006.... - Combined α-tocopherol and ascorbic acid protects against smoke-induced lung squamous metaplasia in ferretsYuri Kim
Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Lung Cancer 75:15-23. 2012..These data indicate that the combination of antioxidant AT+AA alone exerts protective effects against SM-induced lung lesions through inhibiting cyclin D1 expression and partially restoring retinoic acid levels to normal... - Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferretsChun Liu
Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Cancer Res 63:3138-44. 2003.... - Long-term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in ratsPollyanna R G Chavez
Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 141:1049-55. 2011..Together, these results indicate that chronic, excessive ethanol consumption impairs normal hepatocyte proliferation, which is associated with reduced IGF-1 levels, but promotes hepatic carcinogenesis... - Alpha-tocopherol and ascorbic acid decrease the production of beta-apo-carotenals and increase the formation of retinoids from beta-carotene in the lung tissues of cigarette smoke-exposed ferrets in vitroChun Liu
Nutrition and Cancer Biology Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 134:426-30. 2004.... - The effect of dietary glutathione and coenzyme Q10 on the prevention and treatment of inflammatory bowel disease in miceChun Liu
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
Int J Vitam Nutr Res 74:74-85. 2004..Further studies using additional animal models are required to determine whether GSH or CoQ10 provide a favorable or unfavorable benefit:risk ratio in the prevention or treatment of IBD... - Phasic respiratory modulation of pharyngeal collapsibility via neuromuscular mechanisms in ratsYing Cao
Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Appl Physiol 112:695-703. 2012.... - Low dose beta-carotene supplementation of ferrets attenuates smoke-induced lung phosphorylation of JNK, p38 MAPK, and p53 proteinsChun Liu
Nutrition and Cancer Biology Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 134:2705-10. 2004..These data provide supportive evidence that the beneficial vs. detrimental effects of beta-carotene supplementation are related to the dosage of beta-carotene administered... - Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): a model for human lung cancerYuri Kim
Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Cancer Lett 234:209-19. 2006.... - Exposing ferrets to cigarette smoke and a pharmacological dose of beta-carotene supplementation enhance in vitro retinoic acid catabolism in lungs via induction of cytochrome P450 enzymesChun Liu
Nutrition and Cancer Biology Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 133:173-9. 2003.... - Glossopharyngeal long-term facilitation requires serotonin 5-HT2 and NMDA receptors in ratsYing Cao
Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, BLI 043B, Boston, MA 02115, USA
Respir Physiol Neurobiol 170:164-72. 2010..Hypoxic glossopharyngeal responses were minimally changed after either drug. These data suggest that AIH induces both phasic and tonic glossopharyngeal LTF, which requires activation of 5-HT(2) and NMDA receptors... - The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivoKang Quan Hu
Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
J Biol Chem 281:19327-38. 2006.... - Sleep fragmentation attenuates the hypercapnic (but not hypoxic) ventilatory responses via adenosine A1 receptors in awake ratsChun Liu
Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Respir Physiol Neurobiol 175:29-36. 2011..9 ± 11.8%). Collectively, these results suggest that: (1) 24 h SF does not change isocapnic HVR but causes an attenuation of HCVR; and (2) this attenuation lasts for only a few hours and requires activation of adenosine A1 receptors... - Beta-carotene and beta-apo-14'-carotenoic acid prevent the reduction of retinoic acid receptor beta in benzo[a]pyrene-treated normal human bronchial epithelial cellsPankaj Prakash
Nutrition and Cancer Biology Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, School of Medicine, Tufts University, Boston, MA 02111, USA
J Nutr 134:667-73. 2004..These observations indicate that the growth inhibitory effects of BC and beta-apo-carotenoic acid are through their conversion to RA and upregulation of RARbeta... - Chronic alcohol intake upregulates hepatic expression of carotenoid cleavage enzymes and PPAR in ratsRenata A M Luvizotto
Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr 140:1808-14. 2010..This process may be due to alcohol-induced PPARγ expression and lower vitamin A status in the liver... - β-Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J MiceAnita R Iskandar
Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Room 514, Boston, MA 02111
Cancer Prev Res (Phila) 6:309-20. 2013..In addition, our study establishes a relevant animal lung cancer model for studying tumor growth within emphysematous microenvironments. Cancer Prev Res; 6(4); 309-20. ©2012 AACR... - A simple HPLC method for the comprehensive analysis of cis/trans (Z/E) geometrical isomers of carotenoids for nutritional studiesAntonio J Meléndez-Martínez
Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
Food Chem 138:1341-50. 2013..This is to the best of our knowledge the report of the highest number of carotenoid geometrical isomers separated with a HPLC method. Twenty-six different carotenoid isomers were readily detected in the biological samples... - Formation and maintenance of ventilatory long-term facilitation require NMDA but not non-NMDA receptors in awake ratsMichelle McGuire
Div of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Appl Physiol 105:942-50. 2008..Collectively, these results suggest that activation of NMDA but not non-NMDA receptors is necessary for formation and maintenance of vLTF in awake rats... - Chlormethiazole treatment prevents reduced hepatic vitamin A levels in ethanol-fed ratsChun Liu
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Alcohol Clin Exp Res 26:1703-9. 2002.... - Daily 4-h head-up tilt is effective in preventing muscle but not bone atrophy due to simulated microgravityBiao Sun
Department of Aerospace Physiology, The Fourth Military Medical University, Xi'an, China
J Gravit Physiol 10:29-38. 2003..Daily 4-h HUT, as 4-h STD, is also ineffective in attenuating adverse changes in bone mass, but seems partially effective in preventing declines in mechanical properties due to simulated microgravity... - [Evaluation oxygen free radicals related index before liver transplantation to forejudge prognosis]Chun Liu
the Third Hospital of Peking University, Beijing 100083, China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15:560-2. 2003..The equation is preferable to forejudging prognosis, it can be used to choose from high risk patients to improve survival rate of the patients after operation. Therefore, it is valuable in clinical practise... - Effectiveness of intermittent -Gx gravitation in preventing deconditioning due to simulated microgravityLi Fan Zhang
Department of Aerospace Physiology, Fourth Military Medical University, Xi an 710032, People s Republic of China
J Appl Physiol 95:207-18. 2003..The present work suggests that system specificity in responsiveness to intermittent gravity exposure should be considered one of the prerequisites in proposing intermittent artificial gravity as a potential countermeasure... - Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory responseBernard Meshi
UBC McDonald Research Laboratories, The iCAPTURE Center, St. Paul's Hospital, Vancouver, British Columbia, Canada
Am J Respir Cell Mol Biol 26:52-7. 2002..In this study, the increase in CD4 was associated with cigarette smoke and the increase in CD8 cells with latent Ad infection...