Alice Lichtenstein

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Dietary trans fatty acids and cardiovascular disease risk: past and present
    Alice H Lichtenstein
    JM USDA Human Nutrition Research Center, Tufts University, 711 Washington Street, Boston, MA, 02111, USA
    Curr Atheroscler Rep 16:433. 2014
  2. pmc Effect of diets differing in glycemic index and glycemic load on cardiovascular risk factors: review of randomized controlled-feeding trials
    Aleksandra S Kristo
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nutrients 5:1071-80. 2013
  3. pmc Use of hamster as a model to study diet-induced atherosclerosis
    Alice Dillard
    Cardiovascular Nutrition Laboratory, Jean Mayer U, S, Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab (Lond) 7:89. 2010
  4. pmc Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study
    Diane L McKay
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Nutr J 9:21. 2010
  5. pmc Racial differences in central adiposity in a longitudinal cohort of black and white adolescent females
    David J Tybor
    Friedman School of Nutrition Science and Policy at Tufts University, Boston, MA, USA
    BMC Pediatr 10:2. 2010
  6. ncbi request reprint Modified MyPyramid for Older Adults
    Alice H Lichtenstein
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 138:5-11. 2008
  7. ncbi request reprint Diet, heart disease, and the role of the registered dietitian
    Alice H Lichtenstein
    Nutrition Science and Policy, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Am Diet Assoc 107:205-8. 2007
  8. ncbi request reprint Summary of American Heart Association Diet and Lifestyle Recommendations revision 2006
    Alice H Lichtenstein
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 26:2186-91. 2006
  9. ncbi request reprint Novel soybean oils with different fatty acid profiles alter cardiovascular disease risk factors in moderately hyperlipidemic subjects
    Alice H Lichtenstein
    Cardiovascular Nutrition Laboratory and the Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 84:497-504. 2006
  10. ncbi request reprint Remarks on clinical data concerning dietary supplements that affect antithrombotic therapy
    Alice H Lichtenstein
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Thromb Res 117:71-3; discussion 113-5. 2005

Detail Information

Publications86

  1. ncbi request reprint Dietary trans fatty acids and cardiovascular disease risk: past and present
    Alice H Lichtenstein
    JM USDA Human Nutrition Research Center, Tufts University, 711 Washington Street, Boston, MA, 02111, USA
    Curr Atheroscler Rep 16:433. 2014
    ..Although at this time some issues remain unresolved regarding trans fatty acids and CVD risk factors other than plasma lipoprotein concentrations, they should not affect the final dietary recommendation to limit intake. ..
  2. pmc Effect of diets differing in glycemic index and glycemic load on cardiovascular risk factors: review of randomized controlled-feeding trials
    Aleksandra S Kristo
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nutrients 5:1071-80. 2013
    ..There was either weak or no effect on inflammatory markers. The results of the five randomized controlled trials satisfying the inclusion criteria suggest inconsistent effects of the GI/GL value of the diet on CVD risk factors...
  3. pmc Use of hamster as a model to study diet-induced atherosclerosis
    Alice Dillard
    Cardiovascular Nutrition Laboratory, Jean Mayer U, S, Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab (Lond) 7:89. 2010
    ..In conclusion, at this time the Golden-Syrian hamster does not appear to be a useful model to determine the mechanism(s) of diet-induced development of atherosclerotic lesions...
  4. pmc Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study
    Diane L McKay
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Nutr J 9:21. 2010
    ..A limited number of human feeding trials indicate that walnuts improve some measures of antioxidant status, but not others...
  5. pmc Racial differences in central adiposity in a longitudinal cohort of black and white adolescent females
    David J Tybor
    Friedman School of Nutrition Science and Policy at Tufts University, Boston, MA, USA
    BMC Pediatr 10:2. 2010
    ..We tested for racial differences in age-related growth in waist circumference in a longitudinal cohort of black and white adolescent girls...
  6. ncbi request reprint Modified MyPyramid for Older Adults
    Alice H Lichtenstein
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 138:5-11. 2008
    ..Discussed are newer concerns about potential overnutrition in the current food landscape available to older adults...
  7. ncbi request reprint Diet, heart disease, and the role of the registered dietitian
    Alice H Lichtenstein
    Nutrition Science and Policy, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Am Diet Assoc 107:205-8. 2007
  8. ncbi request reprint Summary of American Heart Association Diet and Lifestyle Recommendations revision 2006
    Alice H Lichtenstein
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 26:2186-91. 2006
  9. ncbi request reprint Novel soybean oils with different fatty acid profiles alter cardiovascular disease risk factors in moderately hyperlipidemic subjects
    Alice H Lichtenstein
    Cardiovascular Nutrition Laboratory and the Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 84:497-504. 2006
    ..A variety of soybean oils were developed with improved oxidative stability and functional characteristics for use as alternatives to partially hydrogenated fat...
  10. ncbi request reprint Remarks on clinical data concerning dietary supplements that affect antithrombotic therapy
    Alice H Lichtenstein
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Thromb Res 117:71-3; discussion 113-5. 2005
  11. ncbi request reprint Essential nutrients: food or supplements? Where should the emphasis be?
    Alice H Lichtenstein
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    JAMA 294:351-8. 2005
    ....
  12. ncbi request reprint Thematic review series: patient-oriented research. Dietary fat, carbohydrate, and protein: effects on plasma lipoprotein patterns
    Alice H Lichtenstein
    Cardiovascular Nutrition Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 47:1661-7. 2006
    ..Such data are needed to allow reassessment and, if necessary, modification of current recommendations...
  13. pmc Nutrient supplements and cardiovascular disease: a heartbreaking story
    Alice H Lichtenstein
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University, Boston MA 02111, USA
    J Lipid Res 50:S429-33. 2009
    ..As a result, we are in a better position to adjudicate new potential relationships as data emerge...
  14. pmc Application of systematic review methodology to the field of nutrition
    Alice H Lichtenstein
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 138:2297-306. 2008
    ..Systematic reviews are a valuable and independent component of decision-making processes by groups responsible for developing science-based recommendations and policies...
  15. ncbi request reprint Influence of hydrogenated fat and butter on CVD risk factors: remnant-like particles, glucose and insulin, blood pressure and C-reactive protein
    Alice H Lichtenstein
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 171:97-107. 2003
    ..These data suggest that, as previously demonstrated, the major CVD risk factor adversely affected by dietary trans fatty acids/partially-hydrogenated fat is LDL-cholesterol levels and total cholesterol/HDL-cholesterol ratios...
  16. pmc Changes in cholesterol homeostasis modify the response of F1B hamsters to dietary very long chain n-3 and n-6 polyunsaturated fatty acids
    Jaime L Lecker
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Lipids Health Dis 10:186. 2011
    ..1% cholesterol [w/w]) or cholesterol-depleted (0.01% cholesterol [w/w] and 10 days prior to killing fed 0.15% lovastatin+2% cholestyramine [w/w])...
  17. ncbi request reprint Dietary fat and cardiovascular disease risk: quantity or quality?
    Alice H Lichtenstein
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Womens Health (Larchmt) 12:109-14. 2003
    ..This would include encouraging abstinence from smoking, habitual physical activity, avoidance of weight gain with age, and responsible limited alcohol intake (one drink for females and two drinks for males per day)...
  18. pmc Substitution of vegetable oil for a partially-hydrogenated fat favorably alters cardiovascular disease risk factors in moderately hypercholesterolemic postmenopausal women
    Sonia Vega-Lopez
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
    Atherosclerosis 207:208-12. 2009
    ..Acceptable alternatives must be adjudicated. Our objective was to assess the effect of a recent commercial fat substitution, corn oil for partially-hydrogenated soybean oil...
  19. ncbi request reprint Palm and partially hydrogenated soybean oils adversely alter lipoprotein profiles compared with soybean and canola oils in moderately hyperlipidemic subjects
    Sonia Vega-Lopez
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 84:54-62. 2006
    ..Partially hydrogenated fat has an unfavorable effect on cardiovascular disease risk. Palm oil is a potential substitute because of favorable physical characteristics...
  20. ncbi request reprint Intake of a single morning dose of standard and novel plant sterol preparations for 4 weeks does not dramatically affect plasma lipid concentrations in humans
    Suhad S AbuMweis
    School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada
    J Nutr 136:1012-6. 2006
    ....
  21. ncbi request reprint Interrelationships between human apolipoprotein A-I and apolipoproteins B-48 and B-100 kinetics using stable isotopes
    Francine K Welty
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 24:1703-7. 2004
    ..Our purpose was to determine the relationship between apolipoprotein (apo) A-I and apoB-48 and apoB-100 metabolism in moderately hypercholesterolemic humans...
  22. ncbi request reprint n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review
    Chenchen Wang
    Tufts New England Medical Center Evidence based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA, USA
    Am J Clin Nutr 84:5-17. 2006
    ..The evidence for the benefits of fish oil is stronger in secondary- than in primary-prevention settings. Adverse effects appear to be minor...
  23. ncbi request reprint Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease
    Arja T Erkkilä
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA HNRCA, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Clin Nutr 80:626-32. 2004
    ..However, limited data exist on the effect of fish intake on actual measures of progression of coronary artery atherosclerosis...
  24. ncbi request reprint Hormonal response to diets high in soy or animal protein without and with isoflavones in moderately hypercholesterolemic subjects
    Barry R Goldin
    Department of Family Medicine and Community Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    Nutr Cancer 51:1-6. 2005
    ..0118). These data suggest that relatively large amounts of soy protein or soy-derived isoflavones had modest and limited sex-specific effects on circulating hormone levels...
  25. ncbi request reprint Study of diet-induced changes in lipoprotein metabolism in two strains of Golden-Syrian hamsters
    Suzanne E Dorfman
    Cardiovascular Nutrition Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Nutr 133:4183-8. 2003
    ..CR hamsters fed a 10 g/100 g saturated fat containing 0.1 g/100 g dietary cholesterol for 10 wk appear to be a good model for investigating diet-induced change in plasma lipids...
  26. ncbi request reprint Soy protein reduces triglyceride levels and triglyceride fatty acid fractional synthesis rate in hypercholesterolemic subjects
    Yanwen Wang
    School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, Ste Anne de Bellevue, QE, Canada H9X 3V
    Atherosclerosis 173:269-75. 2004
    ..009) but had no significant effect on LDL, HDL cholesterol levels, or FC-FSR. These data demonstrate that dietary protein type modulates circulating TG and cholesterol levels in hypercholesterolemic individuals by distinct mechanisms...
  27. ncbi request reprint Effect of hydrogenated and saturated, relative to polyunsaturated, fat on immune and inflammatory responses of adults with moderate hypercholesterolemia
    Sung Nim Han
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Lipid Res 43:445-52. 2002
    ....
  28. ncbi request reprint The maximal amount of dietary alpha-tocopherol intake in U.S. adults (NHANES 2001-2002)
    Xiang Gao
    The Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Nutr 136:1021-6. 2006
    ..Careful selection of the highest vitamin E source foods within these groups could further increase the likelihood of meeting the current recommended daily allowance...
  29. pmc Impact of dietary fat type within the context of altered cholesterol homeostasis on cholesterol and lipoprotein metabolism in the F1B hamster
    Jaime L Lecker
    Cardiovascular Nutrition Laboratory, Jean Mayer US Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 59:1491-501. 2010
    ....
  30. ncbi request reprint Dietary fat type affects vitamins C and E and biomarkers of oxidative status in peripheral and brain tissues of golden Syrian hamsters
    Concepción Sánchez-Moreno
    Nutrition and Neurocognition Laboratory, Cardiovascular Nutrition Research Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 134:655-60. 2004
    ..03) plasma uric acid concentration than the other groups. The results of this study provide new evidence concerning the effect of dietary fat on antioxidant status, which is important for the maintenance of good health...
  31. ncbi request reprint Dietary fatty acids and cholesterol differentially modulate HDL cholesterol metabolism in Golden-Syrian hamsters
    Suzanne E Dorfman
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
    J Nutr 135:492-8. 2005
    ....
  32. ncbi request reprint Antioxidant vitamin supplements and cardiovascular disease
    Penny M Kris-Etherton
    Circulation 110:637-41. 2004
  33. ncbi request reprint Fiber and cardiovascular disease risk: how strong is the evidence?
    Arja T Erkkilä
    Department of Clinical Nutrition, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    J Cardiovasc Nurs 21:3-8. 2006
    ..Despite this contradiction, the evidence promotes a food-based approach favoring increased intake of whole-grain cereals, fruit, and vegetables providing a mixture of different types of fibers for CVD prevention...
  34. ncbi request reprint Reduced adiponectin and HDL cholesterol without elevated C-reactive protein: clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome
    Leslie B Gordon
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA
    J Pediatr 146:336-41. 2005
    ..We determined whether children with HGPS demonstrate abnormalities in known biomarkers for cardiovascular disease (CVD) risk...
  35. ncbi request reprint Plasma transport of vitamin K in men using deuterium-labeled collard greens
    Arja T Erkkilä
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Metabolism 53:215-21. 2004
    ..8 hours (n = 3). Deuterated-phylloquinone was not detectable in plasma or TRL fraction at 72 hours. These results suggest rapid uptake and transport of physiologic doses of phylloquinone...
  36. pmc Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse
    Shu Wang
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Atherosclerosis 204:147-55. 2009
    ..These data suggest that lower omega-6:EPA+DHA ratio diets lowered some measures of inflammation and Mphi cholesterol accumulation, which was associated with less aortic lesion formation in LDLr-/- mice...
  37. doi request reprint Diet-induced obesity and spatial cognition in young male rats
    Nicole Jurdak
    Department of Psychology, Tufts University, Medford, Massachusetts, USA
    Nutr Neurosci 11:48-54. 2008
    ..It is hypothesized that these deficits arise from metabolic insults that leave the brain vulnerable to alterations in insulin sensitivity and glucose metabolism...
  38. ncbi request reprint Dietary fatty acids differentially modulate messenger RNA abundance of low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and microsomal triglyceride transfer protein in Golden-Syrian hamsters
    Suzanne E Dorfman
    Cardiovascular Nutrition Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 55:635-41. 2006
    ..These results suggest that the substitution of canola and soybean oils for butter results in lower nHDL-C concentrations that may be related to increased mRNA abundance of the LDL receptor, SREBP-2, and MTP genes...
  39. ncbi request reprint Determinants of plasma dihydrophylloquinone in men and women
    Arja T Erkkilä
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Br J Nutr 93:701-8. 2005
    ..Despite this caveat, higher plasma dihydrophylloquinone was associated with higher dihydrophylloquinone intake and higher trans fatty acid intake...
  40. ncbi request reprint The metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein (a) in human beings
    Jennifer L Jenner
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Metabolism 54:361-9. 2005
    ....
  41. ncbi request reprint Understanding the complexity of trans fatty acid reduction in the American diet: American Heart Association Trans Fat Conference 2006: report of the Trans Fat Conference Planning Group
    Robert H Eckel
    University of Colorado at Denver and Health Sciences Center, USA
    Circulation 115:2231-46. 2007
    ..The conference demonstrated the value of collaboration between the food industry and health and nutrition professionals, and this conference model should be used to address other food development, processing, and/or technology issues...
  42. ncbi request reprint Lipoprotein metabolism in subjects with hepatic lipase deficiency
    Marju Tilly-Kiesi
    Helsinki University Central Hospital, Helsinki, Finland
    Metabolism 53:520-5. 2004
    ..HL deficiency may result in a lipoprotein pattern associated with low heart disease risk...
  43. pmc Gender-specific differences in the kinetics of nonfasting TRL, IDL, and LDL apolipoprotein B-100 in men and premenopausal women
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:1838-43. 2008
    ..To investigate mechanisms underlying gender differences in serum lipoprotein concentrations, the kinetic behavior of apoB-100 was assessed...
  44. ncbi request reprint Plant sterols and blood lipid levels
    Alice H Lichtenstein
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Clin Nutr Metab Care 5:147-52. 2002
    ..Few side-effects of plant sterols have been reported, with the exception of decreased levels of circulating carotenoids...
  45. pmc Extended-release niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and ApoB-containing lipoproteins
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:1672-8. 2008
    ..Extended-release niacin effectively lowers plasma TG levels and raises plasma high-density lipoprotein (HDL) cholesterol levels, but the mechanisms responsible for these effects are unclear...
  46. pmc Waist-to-height ratio is correlated with height in US children and adolescents aged 2-18 years
    David J Tybor
    Friedman School of Nutrition Science and Policy at Tufts University, Boston, MA, USA
    Int J Pediatr Obes 3:148-51. 2008
    ..Future research should investigate how this affects relationships between central adiposity and cardiovascular disease risk factors across these ages, and how using a power other than 1 might reduce bias and improve precision...
  47. ncbi request reprint Approaches to measuring cholesterol absorption in humans
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer US DA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 174:197-205. 2004
    ..Emphasis is placed on the strengths, technical and interpretational limitations and their applicability for use in metabolic, small-scale outpatient, population and large-scale intervention studies...
  48. ncbi request reprint Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston Mass 02111, USA
    Arterioscler Thromb Vasc Biol 24:1092-7. 2004
    ....
  49. ncbi request reprint Effects of dietary palmitoleic acid on plasma lipoprotein profile and aortic cholesterol accumulation are similar to those of other unsaturated fatty acids in the F1B golden Syrian hamster
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:215-21. 2009
    ..These data suggest that an oil relatively high in palmitoleic acid does not adversely affect plasma lipoprotein profiles or aortic cholesterol accumulation and was similar to other unsaturated fatty acid-rich oils...
  50. ncbi request reprint Men and women differ in lipoprotein response to dietary saturated fat and cholesterol restriction
    Zhengling Li
    Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:3428-33. 2003
    ..These data are consistent with the concept that middle aged/elderly men may have a more favorable lipoprotein response to a low fat, low cholesterol diet than postmenopausal women...
  51. pmc Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD
    Nirupa R Matthan
    Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 50:1927-35. 2009
    ..These data suggest that impaired cholesterol homeostasis, reflected by lower synthesis and higher absorption marker concentrations, are highly significant independent predictors of prevalent CVD in this study population...
  52. pmc The StrongWomen-Healthy Hearts program: reducing cardiovascular disease risk factors in rural sedentary, overweight, and obese midlife and older women
    Sara C Folta
    John Hancock Center for Physical Activity and Nutrition, Friedman School of Nutrition Science and Policy, Tufts University, 150 Harrison Ave, Boston, MA 02111, USA
    Am J Public Health 99:1271-7. 2009
    ..We tested a community-based intervention designed to reduce cardiovascular disease risk in sedentary midlife and older women who were overweight or obese...
  53. pmc Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial
    Nirupa R Matthan
    Cardiovascular Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 51:202-9. 2010
    ..The magnitude of these alterations were similar between cases and controls and do not explain differences in outcomes with pravastatin treatment...
  54. pmc Whole-grain intake and cereal fiber are associated with lower abdominal adiposity in older adults
    Nicola M McKeown
    Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:1950-5. 2009
    ..Higher intakes of cereal fiber, particularly from whole-grain sources, are associated with lower total percent body fat and percent trunk fat mass in older adults...
  55. pmc Altering dietary lysine:arginine ratio has little effect on cardiovascular risk factors and vascular reactivity in moderately hypercholesterolemic adults
    Sonia Vega-Lopez
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Atherosclerosis 210:555-62. 2010
    ..Information is scarce regarding the effect of dietary protein type, with specific focus on the lysine-to-arginine (Lys:Arg) ratio, on cardiovascular risk factors and vascular reactivity in humans...
  56. pmc Long-term fatty acid stability in human serum cholesteryl ester, triglyceride, and phospholipid fractions
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 51:2826-32. 2010
    ..Thus, our data demonstrate that storage at -80 degrees C up to 10 years does not significantly influence serum CE, TG, or PL fatty acid profiles...
  57. ncbi request reprint Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects
    Alice H Lichtenstein
    Cardiovascular Nutrition Laboratory and Lipid Metabolism Laboratory, JM HNRC Human Nutrition Research Center on Aging at Tufts University, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 22:1852-8. 2002
    ..The objective of this study was to assess the independent effect of soy relative to common sources of animal protein and soy-derived isoflavones on blood lipids...
  58. ncbi request reprint Phylloquinone absorption from phylloquinone-fortified oil is greater than from a vegetable in younger and older men and women
    Sarah L Booth
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 132:2609-12. 2002
    ..001). These data emphasize that the use of different approaches for the assessment of vitamin K absorption can result in disparate conclusions...
  59. ncbi request reprint Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects
    Alice H Lichtenstein
    Cardiovascular Nutrition Research Program and Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Lipid Res 43:264-73. 2002
    ..Female and male subjects responded similarly. The TLC/Step 2 diet resulted in a decrease in some CVD risk factors and no apparent adverse effects in others...
  60. pmc Factors related to cardiovascular disease risk reduction in midlife and older women: a qualitative study
    Sara C Folta
    John Hancock Center for Physical Activity and Nutrition, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Prev Chronic Dis 5:A06. 2008
    ..In this study, we used qualitative methods to better understand knowledge and awareness about CVD in women, perceived threat of CVD, barriers to heart-healthy eating and physical activity, and intervention strategies for behavior change...
  61. ncbi request reprint Plasma antioxidant capacity in response to diets high in soy or animal protein with or without isoflavones
    Sonia Vega-Lopez
    Cardiovascular Nutrition Laboratory and the Carotenoids and Health Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 81:43-9. 2005
    ..Several clinical trials have suggested that soy intake decreases oxidative stress. Soy isoflavones have antioxidant properties in vitro, but results of supplementation in clinical trials are inconclusive...
  62. ncbi request reprint Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Lipid Res 44:800-6. 2003
    ..26, P < 0.005) and negatively associated with a percent change in beta-sitosterol (r = -0.21, P < 0.01). These data suggest that changes in stenosis were attributable, in part, to changes in cholesterol metabolism...
  63. ncbi request reprint Effects of fish oil supplementation on kidney transplantation: a systematic review and meta-analysis of randomized, controlled trials
    Athina Tatsioni
    Tufts New England Medical Center, Evidence Based Practice Center, Institute for Clinical Research and Health Policy Studies, 750 Washington Street, Box 63, Boston, MA 0211, USA
    J Am Soc Nephrol 16:2462-70. 2005
    ..00, 95% confidence interval 0.96 to 1.05). The available data (mostly derived from older studies with important methodologic limitations) do not demonstrate a consistent, clinically important benefit of fish oil in kidney transplantation...
  64. ncbi request reprint Effect of soy protein from differently processed products on cardiovascular disease risk factors and vascular endothelial function in hypercholesterolemic subjects
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Am J Clin Nutr 85:960-6. 2007
    ..The magnitude of the effect of soy protein on lipoprotein concentrations is variable. This discordance is likely attributable to the various forms of soy protein used and to unrecognized shifts in dietary fatty acid, cholesterol, and fiber...
  65. ncbi request reprint TRL, IDL, and LDL apolipoprotein B-100 and HDL apolipoprotein A-I kinetics as a function of age and menopausal status
    Nirupa R Matthan
    Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 25:1691-6. 2005
    ..To determine mechanisms contributing to the altered lipoprotein profile associated with aging and menopause, apolipoprotein B-100 (apoB-100) and apoA-I kinetic behavior was assessed...
  66. ncbi request reprint Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:1746-53. 2007
    ..Atorvastatin-mediated changes in cholesterol homeostasis may contribute to apoB PR regulation...
  67. pmc Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women
    Francine K Welty
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Metabolism 56:910-4. 2007
    ..Sixty-two percent of the variability in PR and 71% of the variability in FCR were due to BMI in men and only 3% and 23%, respectively, in women. In conclusion, BMI has a significant effect on apo A-I PR and FCR in men but not in women...
  68. doi request reprint Alternative approaches to the calculation of nutrient density
    Eileen Kennedy
    Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts 02111, USA
    Nutr Rev 66:703-9. 2008
    ..Fruits and vegetables are substantially more nutrient-dense than items from other food groups. There is an imperative need for a simple, consistent method to guide consumers in making healthier food choices...
  69. ncbi request reprint A systematic review and meta-analysis of the impact of omega-3 fatty acids on selected arrhythmia outcomes in animal models
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Metabolism 54:1557-65. 2005
    ..It is not known whether omega-3 fatty-acid supplementation has antiarrhythmic effects in other disease settings not related to ischemia...
  70. pmc Independent effects of age-related changes in waist circumference and BMI z scores in predicting cardiovascular disease risk factors in a prospective cohort of adolescent females
    David J Tybor
    Friedman School of Nutrition Science and Policy at Tufts University, Boston, MA, USA
    Am J Clin Nutr 93:392-401. 2011
    ..The use of longitudinal data to investigate the relation between changes in fat distribution and the emergence of risk factors is limited...
  71. ncbi request reprint Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD
    Arja T Erkkilä
    School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
    J Lipid Res 47:2814-9. 2006
    ..Consistent with higher reported fish intake, higher levels of plasma TG and PL DHA are associated with less progression of coronary atherosclerosis in postmenopausal women with CAD...
  72. ncbi request reprint Dietary recommendations for children and adolescents: a guide for practitioners: consensus statement from the American Heart Association
    Samuel S Gidding
    Circulation 112:2061-75. 2005
    ..This scientific statement summarizes current available information on cardiovascular nutrition in children and makes recommendations for both primordial and primary prevention of cardiovascular disease beginning at a young age...
  73. ncbi request reprint An investigation of hormone and lipid associations after weight loss in women
    Sylvia Santosa
    School of Dietetics and Human Nutrition, McGill University, Montreal, Canada
    J Am Coll Nutr 26:250-8. 2007
    ....
  74. ncbi request reprint Soy protein favorably affects LDL size independently of isoflavones in hypercholesterolemic men and women
    Sophie Desroches
    Institute on Nutraceuticals and Functional Foods, Laval University, Ste Foy, Quebec, Canada
    J Nutr 134:574-9. 2004
    ..05) relative to animal protein. Isoflavones did not affect these LDL particle characteristics. Soy protein shifted LDL particle distribution to a less atherogenic pattern and this effect is independent of soy's isoflavone component...
  75. ncbi request reprint Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee
    Alice H Lichtenstein
    Circulation 114:82-96. 2006
    ..By adhering to these diet and lifestyle recommendations, Americans can substantially reduce their risk of developing cardiovascular disease, which remains the leading cause of morbidity and mortality in the United States...
  76. ncbi request reprint 2006-2007 American Diabetes Association Nutrition Recommendations: issues for practice translation
    Judith Wylie-Rosett
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Am Diet Assoc 107:1296-304. 2007
  77. ncbi request reprint Dietary protein type and cardiovascular disease risk factors
    Sonia Vega-Lopez
    USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Prev Cardiol 8:31-40. 2005
    ....
  78. ncbi request reprint Meeting adequate intake for dietary calcium without dairy foods in adolescents aged 9 to 18 years (National Health and Nutrition Examination Survey 2001-2002)
    Xiang Gao
    Department of Nutrition, Harvard University School of Public Health, Boston, MA 02111, USA
    J Am Diet Assoc 106:1759-65. 2006
    ..However, no studies have addressed whether dairy-free diets can provide adequate calcium while meeting other nutrient recommendations...
  79. ncbi request reprint Gender differences in plasma lipid response to dietary fat
    Annie Lapointe
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Nutr Rev 64:234-49. 2006
    ....
  80. ncbi request reprint Fish consumption shifts lipoprotein subfractions to a less atherogenic pattern in humans
    Zhengling Li
    Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 134:1724-8. 2004
    ..Neither diet affected VLDL and LDL particle size. Our data indicate that within the context of a diet restricted in fat and cholesterol, a higher fish content favorably affects VLDL and HDL subspecies...
  81. ncbi request reprint Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review
    Ethan M Balk
    Tufts New England Medical Center Evidence based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, NEMC 63, Boston, MA 02111, USA
    Atherosclerosis 189:19-30. 2006
    ..The evidence regarding the effects of omega-3 fatty acids on hs-CRP is inconclusive, as are data on ALA...
  82. ncbi request reprint Phylloquinone intake and risk of cardiovascular diseases in men
    Arja T Erkkilä
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Nutr Metab Cardiovasc Dis 17:58-62. 2007
    ....
  83. ncbi request reprint Effect of a therapeutic lifestyle change diet on immune functions of moderately hypercholesterolemic humans
    Sung Nim Han
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 44:2304-10. 2003
    ..This might be a clinically important benefit, considering the decline of T cell-mediated immune functions with aging and evidence of impaired immune function associated with hypercholesterolemia...
  84. ncbi request reprint The effect of soybean-based foods on plasma lipid and lipoprotein concentrations
    Alice H Lichtenstein
    Am J Clin Nutr 86:1253; author reply 1253-4. 2007
  85. ncbi request reprint A collaborative effort to apply the evidence-based review process to the field of nutrition: challenges, benefits, and lessons learned
    Ethan M Balk
    Tufts New England Medical Center Evidence based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Clin Nutr 85:1448-56. 2007
    ..The goals of these systematic reviews, the processes that were used, the benefits and limitations of the collaboration, and the conclusions of the reviews, including recommendations for future research, are summarized here...
  86. ncbi request reprint Immunological effects of low-fat diets with and without weight loss
    Michelle S Santos
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Am Coll Nutr 22:174-82. 2003
    ..The immunologic effects of isocaloric reduced- and low-fat diets and a voluntary calorie-restricted low-fat diet resulting in weight loss were compared to the immunologic effects of an average American diet in hyperlipidemic individuals...

Research Grants23

  1. SOY PROTEIN +/- ISOFLAVONOIDS AND PLASMA LIPIDS
    Alice Lichtenstein; Fiscal Year: 2002
    ..The results of these studies, whether positive or negative, should contribute to the data base on which to formulate more specific public health recommendations with respect to decreasing risk of developing CHD. ..
  2. Cholesterol Homeostasis in Framingham Offspring Study
    Alice Lichtenstein; Fiscal Year: 2006
    ..abstract_text> ..
  3. DIETARY FAT, PLASMA LIPIDS AND OTHER CHD RISK FACTORS.
    Alice Lichtenstein; Fiscal Year: 2002
    ..The investigators state that data derived from the proposed studies could contribute to the database on which to formulate more specific public health recommendations regarding the variables described. ..
  4. SOY PROTEIN +/- ISOFLAVONOIDS AND PLASMA LIPIDS
    Alice Lichtenstein; Fiscal Year: 2001
    ..The results of these studies, whether positive or negative, should contribute to the data base on which to formulate more specific public health recommendations with respect to decreasing risk of developing CHD. ..
  5. Evaluation of Glycemic Index to Assess Diet-Associated Chronic Disease Risk
    Alice Lichtenstein; Fiscal Year: 2007
    ....
  6. Evaluation of Glycemic Index to Assess Diet-Associated Chronic Disease Risk
    Alice Lichtenstein; Fiscal Year: 2009
    ....
  7. Nutrition & Cardiovascular Disease Training Program
    Alice Lichtenstein; Fiscal Year: 2007
    ..The symposia, seminars and meetings of institutions in the greater Boston area further serve to supplement these resources. ..
  8. Evaluation of Glycemic Index to Assess Diet-Associated Chronic Disease Risk
    Alice H Lichtenstein; Fiscal Year: 2010
    ....
  9. Cholesterol Homeostasis in Framingham Offspring Study
    Alice Lichtenstein; Fiscal Year: 2005
    ..abstract_text> ..
  10. Cholesterol Homeostasis in Framingham Offspring Study
    Alice Lichtenstein; Fiscal Year: 2004
    ..abstract_text> ..
  11. Cholesterol Homeostasis in Framingham Offspring Study
    Alice Lichtenstein; Fiscal Year: 2003
    ..abstract_text> ..
  12. DIETARY FAT, PLASMA LIPIDS AND OTHER CHD RISK FACTORS.
    Alice Lichtenstein; Fiscal Year: 2000
    ..The investigators state that data derived from the proposed studies could contribute to the database on which to formulate more specific public health recommendations regarding the variables described. ..
  13. SOY PROTEIN +/- ISOFLAVONOIDS AND PLASMA LIPIDS
    Alice Lichtenstein; Fiscal Year: 1999
    ..The results of these studies, whether positive or negative, should contribute to the data base on which to formulate more specific public health recommendations with respect to decreasing risk of developing CHD. ..
  14. SOY PROTEIN +/- ISOFLAVONOIDS AND PLASMA LIPIDS
    Alice Lichtenstein; Fiscal Year: 2000
    ..The results of these studies, whether positive or negative, should contribute to the data base on which to formulate more specific public health recommendations with respect to decreasing risk of developing CHD. ..
  15. DIETARY FAT, PLASMA LIPIDS AND OTHER CHD RISK FACTORS.
    Alice Lichtenstein; Fiscal Year: 2001
    ..The investigators state that data derived from the proposed studies could contribute to the database on which to formulate more specific public health recommendations regarding the variables described. ..
  16. DIETARY FAT, PLASMA LIPIDS AND OTHER CHD RISK FACTORS.
    Alice Lichtenstein; Fiscal Year: 2003
    ..The investigators state that data derived from the proposed studies could contribute to the database on which to formulate more specific public health recommendations regarding the variables described. ..
  17. Diet Quality and CVD Risk Factors in a Family Based Weight Management Study
    Alice H Lichtenstein; Fiscal Year: 2010
    ..S., a public health problem that threatens to overwhelm our healthcare system. (End of Abstract) ..