K Lewis

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint In search of natural substrates and inhibitors of MDR pumps
    K Lewis
    Biotechnology Center, Department of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA
    J Mol Microbiol Biotechnol 3:247-54. 2001
  2. ncbi request reprint Translocases: a bacterial tunnel for drugs and proteins
    K Lewis
    Biotechnology Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
    Curr Biol 10:R678-81. 2000
  3. pmc Programmed death in bacteria
    K Lewis
    Biotechnology Center, Tufts University, Medford, Massachusetts 02155, USA
    Microbiol Mol Biol Rev 64:503-14. 2000
  4. ncbi request reprint Human longevity: an evolutionary approach
    K Lewis
    Biotechnology Center, Tufts University, Medford, MA 02155, USA
    Mech Ageing Dev 109:43-51. 1999
  5. pmc Purification and ligand binding of EmrR, a regulator of a multidrug transporter
    A Brooun
    Biotechnology Center, Tufts University, Medford, Massachusetts 02155, USA
    J Bacteriol 181:5131-3. 1999
  6. pmc Emr, an Escherichia coli locus for multidrug resistance
    O Lomovskaya
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Proc Natl Acad Sci U S A 89:8938-42. 1992
  7. pmc EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB
    O Lomovskaya
    Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305 5402, USA
    J Bacteriol 177:2328-34. 1995
  8. pmc A functional analysis of Notch mutations in Drosophila
    K Brennan
    Department of Zoology, University of Cambridge, United Kingdom
    Genetics 147:177-88. 1997
  9. ncbi request reprint An E. coli gene emrD is involved in adaptation to low energy shock
    V Naroditskaya
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Biochem Biophys Res Commun 196:803-9. 1993
  10. pmc Cloning of an organic solvent-resistance gene in Escherichia coli: the unexpected role of alkylhydroperoxide reductase
    A A Ferrante
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA
    Proc Natl Acad Sci U S A 92:7617-21. 1995

Collaborators

  • J C Tiller
  • I I Severina
  • A Brooun
  • A M Klibanov
  • K Brennan
  • O Lomovskaya
  • V P Skulachev
  • C J Liao
  • M S Muntyan
  • A A Ferrante
  • J J Tomashek
  • A M Arias
  • R Tateson
  • V Naroditskaya
  • A Matin
  • J Augliera
  • N Y Fang
  • M J Schlosser

Detail Information

Publications12

  1. ncbi request reprint In search of natural substrates and inhibitors of MDR pumps
    K Lewis
    Biotechnology Center, Department of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA
    J Mol Microbiol Biotechnol 3:247-54. 2001
    ..aureus. In E. coli, the EmrR sensor of the MarR repressor family binds unrelated neutral molecules, allowing for expression of the transenvelope EmrAB pump...
  2. ncbi request reprint Translocases: a bacterial tunnel for drugs and proteins
    K Lewis
    Biotechnology Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
    Curr Biol 10:R678-81. 2000
    ..The TolC protein links the translocases to the external environment. The recently determined crystal structure of TolC shows how this universal tunnel operates...
  3. pmc Programmed death in bacteria
    K Lewis
    Biotechnology Center, Tufts University, Medford, Massachusetts 02155, USA
    Microbiol Mol Biol Rev 64:503-14. 2000
    ..Apoptosis-like elimination of defective cells in S. cerevisiae and protozoa suggests that all unicellular life forms evolved altruistic programmed death that serves a variety of useful functions...
  4. ncbi request reprint Human longevity: an evolutionary approach
    K Lewis
    Biotechnology Center, Tufts University, Medford, MA 02155, USA
    Mech Ageing Dev 109:43-51. 1999
    ..Decreased emotional support and mastery are mortality risk factors in the elderly, supporting this hypothesis of programmed death in humans, and providing a rationale for increasing longevity...
  5. pmc Purification and ligand binding of EmrR, a regulator of a multidrug transporter
    A Brooun
    Biotechnology Center, Tufts University, Medford, Massachusetts 02155, USA
    J Bacteriol 181:5131-3. 1999
    ..Equilibrium dialysis experiments suggested one bound ligand per monomer of the dimeric EmrR...
  6. pmc Emr, an Escherichia coli locus for multidrug resistance
    O Lomovskaya
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Proc Natl Acad Sci U S A 89:8938-42. 1992
    ..Disruption of emrB significantly increased sensitivity of cells to uncouplers. The cellular content of uncoupler increased in the order: overexpressed emrB cells greater than wild type greater than emrB-...
  7. pmc EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB
    O Lomovskaya
    Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305 5402, USA
    J Bacteriol 177:2328-34. 1995
    ..Some of the chemicals that induce the pump serve as its substrates, suggesting that their extrusion is the natural function of the pump...
  8. pmc A functional analysis of Notch mutations in Drosophila
    K Brennan
    Department of Zoology, University of Cambridge, United Kingdom
    Genetics 147:177-88. 1997
    ..In addition our results indicate that there may be discrete regions of the Notch protein required for each function...
  9. ncbi request reprint An E. coli gene emrD is involved in adaptation to low energy shock
    V Naroditskaya
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Biochem Biophys Res Commun 196:803-9. 1993
    ..It is suggested that EmrD is a new bacterial multidrug resistance pump that participates in a low energy shock adaptive response...
  10. pmc Cloning of an organic solvent-resistance gene in Escherichia coli: the unexpected role of alkylhydroperoxide reductase
    A A Ferrante
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA
    Proc Natl Acad Sci U S A 92:7617-21. 1995
    ..Mutants resistant to a mixture of xylene and tetralin were isolated from the ahpC mutant but not from the wild-type strain...
  11. pmc Designing surfaces that kill bacteria on contact
    J C Tiller
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 98:5981-5. 2001
    ..In contrast, the number of viable bacterial cells did not decline significantly after spraying on such common materials as ceramics, plastics, metals, and wood...
  12. ncbi request reprint Transfer of cationic antibacterial agents berberine, palmatine, and benzalkonium through bimolecular planar phospholipid film and Staphylococcus aureus membrane
    I I Severina
    Department of Bioenergetics, A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russia
    IUBMB Life 52:321-4. 2001
    ..The berberine accumulation was prevented by protonophore CCCP and was stimulated by mutation in the MDR pump NorA. It is concluded that the plant alkaloids and benzalkonium are penetrating cations and substrates of an MDR pump...