Stuart Levy

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. pmc Role of the multidrug resistance regulator MarA in global regulation of the hdeAB acid resistance operon in Escherichia coli
    Cristian Ruiz
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    J Bacteriol 190:1290-7. 2008
  2. pmc Honeybees and tetracycline resistance
    Stuart B Levy
    School of Medicine, Tufts University, Boston, Massachusetts, USA
    MBio 4:e00045-13. 2013
  3. pmc Novel genes involved in Pseudomonas fluorescens Pf0-1 motility and biofilm formation
    Matthew D Mastropaolo
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts, USA
    Appl Environ Microbiol 78:4318-29. 2012
  4. pmc SoxS increases the expression of the zinc uptake system ZnuACB in an Escherichia coli murine pyelonephritis model
    Douglas M Warner
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Bacteriol 194:1177-85. 2012
  5. pmc Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens
    Mark W Silby
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Centre for Adaptation Genetics and Drug Resistance, Boston, MA 02111, USA
    Genome Biol 10:R51. 2009
  6. pmc The marC gene of Escherichia coli is not involved in multiple antibiotic resistance
    Patrick F McDermott
    Antimicrob Agents Chemother 52:382-3. 2008
  7. ncbi request reprint Global antimicrobial resistance alerts and implications
    Stuart B Levy
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Clin Infect Dis 41:S219-20. 2005
  8. ncbi request reprint Antibiotic resistance-the problem intensifies
    Stuart B Levy
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Adv Drug Deliv Rev 57:1446-50. 2005
  9. pmc Yersinia pestis AcrAB-TolC in antibiotic resistance and virulence
    Ida M Lister
    Center of Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 56:1120-3. 2012
  10. pmc Antibacterial household products: cause for concern
    S B Levy
    Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Emerg Infect Dis 7:512-5. 2001

Research Grants

Collaborators

Detail Information

Publications57

  1. pmc Role of the multidrug resistance regulator MarA in global regulation of the hdeAB acid resistance operon in Escherichia coli
    Cristian Ruiz
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    J Bacteriol 190:1290-7. 2008
    ..5. These findings show that repression of hdeAB by MarA depends on pH, growth phase, and other regulators of hdeAB and is associated with reduced resistance to acid conditions...
  2. pmc Honeybees and tetracycline resistance
    Stuart B Levy
    School of Medicine, Tufts University, Boston, Massachusetts, USA
    MBio 4:e00045-13. 2013
    ..Prospective studies that simultaneously track both resistance genes and antibiotic residues will go far in resolving some of the nagging questions that cloud our understanding of antibiotic resistance dissemination...
  3. pmc Novel genes involved in Pseudomonas fluorescens Pf0-1 motility and biofilm formation
    Matthew D Mastropaolo
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts, USA
    Appl Environ Microbiol 78:4318-29. 2012
    ..Our data revealed an additional level of complexity in the control of flagellum function beyond the core genes known to be required and may yield insights into processes important for environmental persistence of P. fluorescens Pf0-1...
  4. pmc SoxS increases the expression of the zinc uptake system ZnuACB in an Escherichia coli murine pyelonephritis model
    Douglas M Warner
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Bacteriol 194:1177-85. 2012
    ..This work implicates SoxS control of znuCB expression as a key factor in persistence of E. coli in murine pyelonephritis...
  5. pmc Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens
    Mark W Silby
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Centre for Adaptation Genetics and Drug Resistance, Boston, MA 02111, USA
    Genome Biol 10:R51. 2009
    ..A functional genomic in vivo expression technology (IVET) screen provided insight into genes used by P. fluorescens in its natural environment and an improved understanding of the ecological significance of diversity within this species...
  6. pmc The marC gene of Escherichia coli is not involved in multiple antibiotic resistance
    Patrick F McDermott
    Antimicrob Agents Chemother 52:382-3. 2008
  7. ncbi request reprint Global antimicrobial resistance alerts and implications
    Stuart B Levy
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Clin Infect Dis 41:S219-20. 2005
  8. ncbi request reprint Antibiotic resistance-the problem intensifies
    Stuart B Levy
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Adv Drug Deliv Rev 57:1446-50. 2005
    ....
  9. pmc Yersinia pestis AcrAB-TolC in antibiotic resistance and virulence
    Ida M Lister
    Center of Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 56:1120-3. 2012
    ..Neither is the Y. pestis pump affected by the efflux pump inhibitor phenylalanine-arginine beta-naphthylamide. In mouse plague models, pump deletion does not have a significant effect on tissue colonization...
  10. pmc Antibacterial household products: cause for concern
    S B Levy
    Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Emerg Infect Dis 7:512-5. 2001
    ..As with antibiotics, prudent use of these products is urged. Their designated purpose is to protect vulnerable patients...
  11. ncbi request reprint Active efflux, a common mechanism for biocide and antibiotic resistance
    S B Levy
    Centre for Adaptation Genetics and Drug Resistance and the Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    J Appl Microbiol 92:65S-71S. 2002
    ..The prudent use of antibiotics and biocides will guard against the selection and propagation of drug-resistant mutants and preserve the efficacy of these valuable anti-infective agents...
  12. ncbi request reprint The 2000 Garrod lecture. Factors impacting on the problem of antibiotic resistance
    Stuart B Levy
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, MA 02111, USA
    J Antimicrob Chemother 49:25-30. 2002
    ..In order to curb the resistance problem, we must encourage the return of the susceptible commensal flora. They are our best allies in reversing antibiotic resistance...
  13. ncbi request reprint Antibiotic resistance: consequences of inaction
    S B Levy
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, MA 02111, USA
    Clin Infect Dis 33:S124-9. 2001
    ..By improving antibiotic use and decreasing resistance gene frequency at the local levels, we can move towards reversing the resistance problem globally...
  14. pmc Role for tandem duplication and lon protease in AcrAB-TolC- dependent multiple antibiotic resistance (Mar) in an Escherichia coli mutant without mutations in marRAB or acrRAB
    Herve Nicoloff
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    J Bacteriol 188:4413-23. 2006
    ..In M113, amplification of acrAB on the duplication led to increased amounts of AcrAB and multidrug resistance. Spontaneous gene duplication represents a new mechanism for mediating multidrug resistance in E. coli through AcrAB-TolC...
  15. pmc Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli
    Cristian Ruiz
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Antimicrob Agents Chemother 54:2125-34. 2010
    ..Such a regulation could contribute to the adaptation and spread of MDR strains and may be targeted to treat antibiotic-resistant E. coli and related pathogens...
  16. ncbi request reprint Transketolase A, an enzyme in central metabolism, derepresses the marRAB multiple antibiotic resistance operon of Escherichia coli by interaction with MarR
    Francis Domain
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Mol Microbiol 66:383-94. 2007
    ..TktA inhibition of repression by MarR demonstrates a previously unrecognized level of control of the expression of marRAB operon...
  17. pmc Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications
    Herve Nicoloff
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Antimicrob Agents Chemother 51:1293-303. 2007
    ..A previously reported unstable amplifiable high-level resistance observed after the prolonged growth of Mar mutants in a low concentration of tetracycline or chloramphenicol can be explained by genomic amplification...
  18. pmc Different effects of transcriptional regulators MarA, SoxS and Rob on susceptibility of Escherichia coli to cationic antimicrobial peptides (CAMPs): Rob-dependent CAMP induction of the marRAB operon
    Douglas M Warner
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, MA 02111, USA
    Microbiology 156:570-8. 2010
    ..coli. The three related transcriptional regulators show different effects on bacterial cell susceptibility to CAMPs...
  19. pmc GyrA interacts with MarR to reduce repression of the marRAB operon in Escherichia coli
    Francis Domain
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    J Bacteriol 192:942-8. 2010
    ..This work, like a previous study examining TktA (12), shows that unrelated proteins can regulate MarR activity. The findings reveal an unexpected regulatory function of GyrA in antibiotic resistance...
  20. ncbi request reprint Substitutions in the interdomain loop of the Tn10 TetA efflux transporter alter tetracycline resistance and substrate specificity
    Frederic M Sapunaric
    The Center for Adaptation Genetics and Drug Resistance and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Microbiology 151:2315-22. 2005
    ..Perhaps this conserved secondary structure accounts for the role of the non-conserved interdomain loop in TetA function...
  21. pmc Integrating Escherichia coli antimicrobial susceptibility data from multiple surveillance programs
    John M Stelling
    Alliance for the Prudent Use of Antibiotics, Boston, Massachusetts 02115, USA
    Emerg Infect Dis 11:873-82. 2005
    ....
  22. pmc Fe(2+)-tetracycline-mediated cleavage of the Tn10 tetracycline efflux protein TetA reveals a substrate binding site near glutamine 225 in transmembrane helix 7
    Laura M McMurry
    Center for Adaptation Genetics and Drug Resistance and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Bacteriol 184:5113-20. 2002
    ..We conclude that the alpha carbon of glutamine 225 is probably within 12 A of the position of the Fe(2+) ion in the Fe(2+)-tetracycline complex bound to the protein...
  23. pmc The periplasmic protein MppA requires an additional mutated locus to repress marA expression in Escherichia coli
    Xiaowen Bina
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Bacteriol 185:1465-9. 2003
    ..Overproduction of MppA repressed marA transcription in TP985 but not in other mppA or marR mutants. Therefore, TP985 contains an additional unknown mutation(s) that facilitates the repression of marA expression by MppA...
  24. ncbi request reprint Activation of the Escherichia coli nfnB gene by MarA through a highly divergent marbox in a class II promoter
    Teresa M Barbosa
    Center for Adaptation Genetics and Drug Resistance and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Mol Microbiol 45:191-202. 2002
    ..The findings imply that other different but physiologically important marbox DNA-MarA interactions take place in the regulation of still uncharacterized members of the mar regulon...
  25. ncbi request reprint Second-site suppressor mutations for the serine 202 to phenylalanine substitution within the interdomain loop of the tetracycline efflux protein Tet(C)
    Frederic M Sapunaric
    Center for Adaptation Genetics and Drug Resistance and the Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 278:28588-92. 2003
    ..The data demonstrate an interaction of the interdomain loop with other distant regions of the protein and support a role of the interdomain loop in mediating tetracycline resistance...
  26. ncbi request reprint MarA-mediated transcriptional repression of the rob promoter
    Thamarai Schneiders
    Center for Adaptation Genetics and Drug Resistance and the Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Biol Chem 281:10049-55. 2006
    ..Transcription experiments in vitro and potassium permanganate footprinting analysis show that MarA affects the RNA polymerase-mediated closed to open complex formation at the rob promoter...
  27. pmc Genetic analysis of the AdnA regulon in Pseudomonas fluorescens: nonessential role of flagella in adhesion to sand and biofilm formation
    Eduardo A Robleto
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Bacteriol 185:453-60. 2003
    ..fluorescens than that described so far for its homolog, FleQ, in P. aeruginosa...
  28. pmc Requirement of polyphosphate by Pseudomonas fluorescens Pf0-1 for competitive fitness and heat tolerance in laboratory media and sterile soil
    Mark W Silby
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Appl Environ Microbiol 75:3872-81. 2009
    ..Our findings reveal a new role for polyphosphate (and the need for proper regulation of its production) in competitive fitness of P. fluorescens in laboratory and soil environments...
  29. ncbi request reprint Novel anti-infection agents: small-molecule inhibitors of bacterial transcription factors
    Todd E Bowser
    Paratek Pharmaceuticals, Inc, 75 Kneeland Street, Boston, MA 02111, USA
    Bioorg Med Chem Lett 17:5652-5. 2007
    ..These compounds lack intrinsic antibacterial activity in vitro and were able to limit a bacterial infection in a mouse model of urinary tract infection...
  30. pmc Combined inactivation of lon and ycgE decreases multidrug susceptibility by reducing the amount of OmpF porin in Escherichia coli
    Valérie Duval
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Antimicrob Agents Chemother 53:4944-8. 2009
    ..In this mutant, a decreased amount of OmpF porin contributes to the lowered drug susceptibility, with a greater effect at 26 degrees C than at 37 degrees C...
  31. pmc Effect of MarA-like proteins on antibiotic resistance and virulence in Yersinia pestis
    Ida M Lister
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, MA 02111, USA
    Infect Immun 78:364-71. 2010
    ..Complementation of the deletions by replacing the deleted genes on the chromosome restored wild-type characteristics. These findings show that two MarA homologs in Y. pestis affect antibiotic susceptibility and virulence...
  32. ncbi request reprint The Escherichia coli transcriptional regulator MarA directly represses transcription of purA and hdeA
    Thamarai Schneiders
    Center for Adaptation Genetics and Drug Resistance and the Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 279:9037-42. 2004
    ..We conclude that MarA, a member of the AraC/XylS family, can act directly as a repressor or an activator, depending on the position and orientation of the marbox within a promoter...
  33. pmc Overlapping protein-encoding genes in Pseudomonas fluorescens Pf0-1
    Mark W Silby
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA
    PLoS Genet 4:e1000094. 2008
    ..We therefore designate iiv14 "cosA". These data suggest that, as is the case with eukaryotes, some bacterial genomes are more densely coded than currently recognized...
  34. ncbi request reprint Antibacterial resistance worldwide: causes, challenges and responses
    Stuart B Levy
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nat Med 10:S122-9. 2004
    ..Drug resistance presents an ever-increasing global public health threat that involves all major microbial pathogens and antimicrobial drugs...
  35. pmc Use of in vivo expression technology to identify genes important in growth and survival of Pseudomonas fluorescens Pf0-1 in soil: discovery of expressed sequences with novel genetic organization
    Mark W Silby
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    J Bacteriol 186:7411-9. 2004
    ..Thus, IVET studies have identified sequences important for soil growth and have revealed a gene organization that was undetected by traditional laboratory approaches...
  36. pmc Evidence that regulatory protein MarA of Escherichia coli represses rob by steric hindrance
    Laura M McMurry
    Center for Adaptation Genetics and Drug Resistance and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Bacteriol 192:3977-82. 2010
    ..When RNAP binding was promoter specific, MarA reduced RNAP access to the rob promoter; there was little or no ternary complex. These findings strongly implicate steric hindrance as the mechanism of repression of rob by MarA...
  37. pmc N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: novel antivirulence agents
    Oak K Kim
    Paratek Pharmaceuticals, Inc, 75 Kneeland Street, Boston, Massachusetts 02111, USA
    J Med Chem 52:5626-34. 2009
    ..These results demonstrate that N-hydroxybenzimidazole inhibitors, exemplified by 14, 22, and 36, are effective antivirulence agents and have the potential to prevent infections caused by Yersinia spp...
  38. pmc Small molecule inhibitors of LcrF, a Yersinia pseudotuberculosis transcription factor, attenuate virulence and limit infection in a murine pneumonia model
    Lynne K Garrity-Ryan
    Paratek Pharmaceuticals, Inc, Boston, MA 02111, USA
    Infect Immun 78:4683-90. 2010
    ..The MAR family of transcription factors is well conserved, with members playing central roles in pathogenesis across bacterial genera; thus, the inhibitors could have broad applicability...
  39. pmc Proteomic detection of non-annotated protein-coding genes in Pseudomonas fluorescens Pf0-1
    Wook Kim
    Center for Adaptation Genetics and Drug Resistance and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 4:e8455. 2009
    ..The 16 newly identified genes improve the quality of the Pf0-1 genome annotation, and the detection of antisense protein-coding genes indicates the under-appreciated complexity of bacterial genome organization...
  40. pmc Increased fitness of Pseudomonas fluorescens Pf0-1 leucine auxotrophs in soil
    Wook Kim
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Appl Environ Microbiol 74:3644-51. 2008
    ..Our findings provide a potential mechanism for the frequent occurrence of auxotrophic mutants of Pseudomonas spp. in the lungs of cystic fibrosis patients...
  41. ncbi request reprint MarA, SoxS and Rob function as virulence factors in an Escherichia coli murine model of ascending pyelonephritis
    Paul Casaz
    Paratek Pharmaceuticals, Inc, 75 Kneeland Street, Boston, MA 02111, USA
    Microbiology 152:3643-50. 2006
    ..Deletion of soxS or rob alone was more detrimental than the removal of marA. Thus, all three proteins contribute to virulence in vivo...
  42. pmc MarA-like regulator of multidrug resistance in Yersinia pestis
    Rupa A Udani
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology, Tufts University School of Medicine, Boston, MA 02111, USA
    Antimicrob Agents Chemother 50:2971-5. 2006
    ..In four of five spontaneous multidrug-resistant mutants of Y. pestis independently selected by growth on tetracycline, the marA47(Yp) gene was overexpressed. The findings suggest that marA47(Yp) is a marA ortholog in Y. pestis...
  43. pmc Food animals and antimicrobials: impacts on human health
    Bonnie M Marshall
    Tufts University School of Medicine, Department of Molecular Biology and Microbiology, Boston, MA 02111, USA
    Clin Microbiol Rev 24:718-33. 2011
    ....
  44. ncbi request reprint IVET experiments in Pseudomonas fluorescens reveal cryptic promoters at loci associated with recognizable overlapping genes
    Mark W Silby
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Microbiology 150:518-20. 2004
  45. ncbi request reprint Selection of non-P-glycoprotein mediated high-level etoposide resistant cell lines by adriamycin with P-gp inhibitors
    Steven Ades
    Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Int J Oncol 28:747-53. 2006
    ..The inhibitor combination of verapamil and PSC833 prevented the emergence of transporter mediated MDR, but not ADR selection of cell lines highly resistant to etoposide...
  46. pmc Relationship between triclosan and susceptibilities of bacteria isolated from hands in the community
    Allison E Aiello
    Center for Social Epidemiology and Public Health, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104 2548, USA
    Antimicrob Agents Chemother 48:2973-9. 2004
    ..Still, a relationship may emerge after longer-term or higher-dose exposure of bacteria to triclosan in the community setting...
  47. pmc Antibacterial cleaning products and drug resistance
    Allison E Aiello
    University of Michigan School of Public Health, Ann Arbor, Michigan 48104 2548, USA
    Emerg Infect Dis 11:1565-70. 2005
    ..However, more extensive and longer term use of triclosan might provide a suitable environment for emergence of resistant species. Further research on this issue is needed...
  48. ncbi request reprint Bacteremia among Kenyan Children
    Stuart B Levy
    N Engl J Med 352:1379-81; author reply 1379-81. 2005
  49. pmc Genome size and antibiotic resistance
    Stuart B Levy
    Antimicrob Agents Chemother 52:2696. 2008
  50. ncbi request reprint Molecular mechanisms of antibacterial multidrug resistance
    Michael N Alekshun
    Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Cell 128:1037-50. 2007
    ..Once established, multidrug-resistant organisms persist and spread worldwide, causing clinical failures in the treatment of infections and public health crises...
  51. pmc Interdomain loop mutation Asp190Cys of the tetracycline efflux transporter TetA(B) decreases affinity for substrate
    Frederic M Sapunaric
    Antimicrob Agents Chemother 51:3036-7. 2007
  52. ncbi request reprint Toward optimal health: the experts discuss antibiotic therapy in primary care. Interview by Jodi Godfrey Meisler
    Stuart B Levy
    J Womens Health Gend Based Med 11:493-9. 2002
  53. ncbi request reprint Mechanisms for resistance in soil
    Stuart B Levy
    Science 312:529. 2006
  54. ncbi request reprint Consumer antibacterial soaps: effective or just risky?
    Allison E Aiello
    Department of Epidemiology and Center for Social Epidemiology and Population Health, University of Michigan, Ann Arbor, Ann Arbor, MI 48104 2548, USA
    Clin Infect Dis 45:S137-47. 2007
    ....
  55. ncbi request reprint The misuse of antibiotics
    Stuart B Levy
    Med Ethics (Burlingt Mass) 11:5-8. 2004
  56. ncbi request reprint Antimicrobial consumer products: where's the benefit? What's the risk?
    Stuart B Levy
    Arch Dermatol 138:1087-8. 2002
  57. pmc Tet protein hybrids
    Stuart B Levy
    Antimicrob Agents Chemother 49:3099. 2005

Research Grants26

  1. The multiple antibiotic resistance (MAR)regulon
    Stuart Levy; Fiscal Year: 2003
    ..coli marRAB serve as a paradigm for insights into related genetic loci in other bacteria also of consequence to human health. Improved understanding will help to suggest novel approaches towards preventing and curing infections. ..
  2. EFFLUX-MEDIATED RESISTANCE TO TETRACYCLINES
    Stuart Levy; Fiscal Year: 2004
    ....
  3. The multiple antibiotic resistance (MAR)regulon
    Stuart Levy; Fiscal Year: 2006
    ..Studies of the E.cofi marRAB serve as a paradigm for insights into related genetic consequence to human health. Improved understanding will help to suggest novel and curing infections. ..
  4. The multiple antibiotic resistance (MAR)regulon
    Stuart Levy; Fiscal Year: 2007
    ..Studies of the E.cofi marRAB serve as a paradigm for insights into related genetic consequence to human health. Improved understanding will help to suggest novel and curing infections. ..
  5. EFFLUX-MEDIATED RESISTANCE TO TETRACYCLINES
    Stuart Levy; Fiscal Year: 2006
    ..Such understanding will also enhance efforts to reverse efflux of other antibiotics and drugs used to treat infectious diseases, including bacteria, fungi and parasites, and cancer. ..
  6. The multiple antibiotic resistance (Mar) regulon
    Stuart Levy; Fiscal Year: 2009
    ..Therefore, understanding how this protein both regulates others and is regulated itself provides a number of novel possible targets for drugs in the control of infectious diseases. ..
  7. MULTIPLE ANTIBIOTIC RESISTANCE (MAR) REGULON
    Stuart Levy; Fiscal Year: 2001
    ....
  8. EFFLUX-MEDIATED RESISTANCE TO TETRACYCLINES
    Stuart Levy; Fiscal Year: 1999
    ..The proposed studies are important for understanding not only resistance to the widely used antibiotic tetracycline, but also for understanding other efflux systems and membrane transport in general. ..
  9. The multiple antibiotic resistance (Mar) regulon
    Stuart B Levy; Fiscal Year: 2010
    ..Therefore, understanding how this protein both regulates others and is regulated itself provides a number of novel possible targets for drugs in the control of infectious diseases. ..