Research Topics
Genomes and Genes
Species | Chao Qiang LaiSummaryAffiliation: Tufts University Country: USA Publications
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Detail Information
Publications
Apolipoprotein A1/C3/A5 haplotypes and serum lipid levelsRui xing Yin
Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, People s Republic of China
Lipids Health Dis 10:140. 2011..The present study was undertaken to detect the association between the ApoA1/C3/A5 gene polymorphisms and their haplotypes with serum lipid levels in the general Chinese population...
The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in SingaporeChao Qiang Lai
Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Lipid Res 44:2365-73. 2003..These data suggest that APOA5 plays a role in the ethnic differences observed for plasma TG and HDL cholesterol concentrations...- Fenofibrate effect on triglyceride and postprandial response of apolipoprotein A5 variants: the GOLDN studyChao Qiang Lai
Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
Arterioscler Thromb Vasc Biol 27:1417-25. 2007..Apolipoprotein A5 (APOA5) is a key determinant of plasma triglyceride (TG) concentrations. Genetic variation at the APOA5 locus could be responsible for some of the observed differences in response to fenofibrate therapy... - Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mappingChao Qiang Lai
JM USDA Human Nutrition Research Center on Aging, Nutrition and Genomics, Tufts University, Boston, MA 02111, United States
Mech Ageing Dev 128:237-49. 2007.... - Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart StudyChao Qiang Lai
Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Circulation 113:2062-70. 2006..Apolipoprotein A5 gene (APOA5) variation is associated with plasma triglycerides (TGs). However, little is known about whether dietary fat modulates this association... - The APOA1/C3/A4/A5 gene cluster, lipid metabolism and cardiovascular disease riskChao Qiang Lai
Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
Curr Opin Lipidol 16:153-66. 2005..In addition, we use genomic information from several species to draw inferences about the location of functional variants within this cluster... - Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart StudyChao Qiang Lai
Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Lipid Res 45:2096-105. 2004..In women, the -1131C allele was associated with a higher hazard ratio for CVD (1.85; 95% confidence interval, 1.03-3.34; P = 0.04), in agreement with the association of this SNP with higher RLPs... - APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populationsDolores Corella
Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111 1524, USA
Arch Intern Med 169:1897-906. 2009..However, replication has been low. Our aim was to study interaction among a functional APOA2 polymorphism, food intake, and body mass index (BMI) in independent populations to replicate findings and to increase their evidence level... - Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean originCaren E Smith
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
Obesity (Silver Spring) 18:327-32. 2010..Analyses of gene-gene interactions may improve understanding of genetically based obesity risk, and underscore the need for further study of groups with multiple ancestral admixtures... - WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intakeChao Qiang Lai
JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
Obesity (Silver Spring) 17:593-600. 2009..Given the high frequency of the major alleles in both populations, we suggest that WDTC1 variation may be an important risk factor contributing to obesity in these populations... - A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMIDolores Corella
Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Nutr 141:2219-25. 2011..006 in BPRHS). No associations with BMI were found at lower SFA intakes. We found no significant interactions with carbohydrate intake. In conclusion, SFA intake modulates the association between FTO and BMI in American populations... - Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated statesPablo Perez-Martinez
Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
Am J Clin Nutr 89:391-9. 2009..Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR) genes has been associated with fasting plasma triacylglycerol... 
Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN studyJian Shen
Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111 1524, USA
Diabetes Care 31:910-5. 2008..We investigated the influences of CRP polymorphisms on baseline CRP levels and fenofibrate-induced CRP changes in subjects with the metabolic syndrome...- Genetic variants at the PDZ-interacting domain of the scavenger receptor class B type I interact with diet to influence the risk of metabolic syndrome in obese men and womenMireia Junyent
Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 139:842-8. 2009..This gene x BMI x diet interaction offers the potential to identify dietary and other lifestyle changes that may obviate the onset of MetS in individuals with a specific genetic background... - The -256T>C polymorphism in the apolipoprotein A-II gene promoter is associated with body mass index and food intake in the genetics of lipid lowering drugs and diet network studyDolores Corella
Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
Clin Chem 53:1144-52. 2007..Apolipoprotein A-II (APOA2) plays an ambiguous role in lipid metabolism, obesity, and atherosclerosis... - ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN studyDaruneewan Warodomwichit
JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
Obesity (Silver Spring) 17:510-7. 2009..Our findings support a significant association between the -11391G>A SNPs and obesity-related traits and the potential to moderate such effects using dietary modification... - Status of vitamins B-12 and B-6 but not of folate, homocysteine, and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adultsDenish Moorthy
Neuroscience and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
J Nutr 142:1554-60. 2012..The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression... - APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart StudyDolores Corella
Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
J Mol Med (Berl) 85:119-28. 2007..In conclusion, the APOA5-1131T>C SNP, which is present in approximately 13% of this population, modulates the effect of fat intake on BMI and obesity risk in both men and women... - Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in hispanics of Caribbean originCaren E Smith
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University School of Medicine, Boston, MA 02111, USA
J Nutr 138:1852-8. 2008..These interactions may be relevant to dietary management of obesity... - Interleukin1beta genetic polymorphisms interact with polyunsaturated fatty acids to modulate risk of the metabolic syndromeJian Shen
Nutrition and Genomics Laboratory, JM U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 137:1846-51. 2007..These results suggested that IL1beta genetic variants were associated with measures of chronic inflammation and the MetS risk, and that genetic influences were more evident among subjects with low (n-3) PUFA intake... - The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN studyboxsJian Shen
Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Lipid Res 49:1839-45. 2008..This phenomenon could be responsible for the observed association of this genetic variant with cardiovascular disease risk... - Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham StudyRoberto Elosua
US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
J Lipid Res 47:990-6. 2006..APOA5 variants were associated with CCA IMT, particularly in obese participants. The mechanism of these associations and the effect modification by obesity are independent of fasting triglyceride levels... - PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases: the Boston Puerto Rican Health StudyChao Qiang Lai
Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
Diabetes 57:809-16. 2008.... - The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adultsXingwang Ye
Department of Health Sciences, Northeastern University, Boston, MA 02115, USA
Psychosom Med 73:385-92. 2011..To examine the associations between variants of genes involved in the uptake, retention, and metabolism of folate and depressive symptoms and to analyze whether such associations are direct or through mediation by folate or homocysteine... - Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health StudyJian Shen
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
Am J Clin Nutr 91:337-42. 2010..Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects of vitamin B-6 independent of homocysteine suggest that additional mechanisms may be involved... - MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folateChao Qiang Lai
Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 91:1377-86. 2010..The S-adenosylmethionine synthetase type 1 (MAT1A) gene encodes a key enzyme in one-carbon nutrient metabolism... - The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health StudyMireia Junyent
The Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University School of Medicine, Boston, MA, USA
J Lipid Res 50:565-73. 2009..002) among smokers. In conclusion, ABCG5/G8 genetic variants modulate HDL-C concentrations, leading to an HDL-C-lowering effect and thereby a potential increased risk for atherosclerosis only in smokers... - The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed siteKris Richardson
Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States of America
PLoS ONE 6:e17944. 2011..These results suggest variation at the PLIN4 locus, and its interaction with PUFA as a modulator of obesity related phenotypes, acts in part through creation of a miR-522 regulatory site... - Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemiaDaruneewan Warodomwichit
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 139:439-46. 2009..62% of energy intake) were associated with atherogenic dyslipidemia in carriers of the minor T allele at the TCF7L2 rs7903146 SNP and may predispose them to MetS, diabetes, and cardiovascular disease... - Population admixture associated with disease prevalence in the Boston Puerto Rican health studyChao Qiang Lai
Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
Hum Genet 125:199-209. 2009.... - Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whitesJosiemer Mattei
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
BMC Genet 10:45. 2009.... - Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham StudyQiong Yang
Department of Biostatistics, Boston University, Boston, MA 02118, USA
J Lipid Res 46:1416-25. 2005..03). Further study of the linkage region and exploration of other variants in PLAGL1 are warranted to define the potential functional variants of HDL-C metabolism... - Speed-mapping quantitative trait loci using microarraysChao Qiang Lai
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Nutrition and Genomics, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
Nat Methods 4:839-41. 2007..We used changes of gene frequency of 2,326 single-feature polymorphisms (SFPs) to map previously identified and additional QTLs affecting lifespan... - Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN studyCaren E Smith
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111 1524, United States
Atherosclerosis 206:500-4. 2009..HDL-C response to exercise varies among individuals, and this variability may be associated with genetic polymorphisms in the key regulators of HDL metabolism including endothelial lipase (LIPG)... - A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWASKris Richardson
Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
BMC Genomics 12:504. 2011.... - Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adultsXiang Gao
Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts 02115, USA
Am J Epidemiol 172:271-8. 2010..Prospective studies are needed to elucidate whether elevated urinary 8-OHdG concentrations can predict the rate of cognitive decline and incident dementia... - Variants of the CD36 gene and metabolic syndrome in Boston Puerto Rican adultsSabrina E Noel
Jean Mayer USDA Human Nutrition Research Center on Aging HNRCA, Tufts University, Boston, MA 02111, United States
Atherosclerosis 211:210-5. 2010..We aimed to determine the association between 6 single nucleotide polymorphisms (SNPs) for CD36 and metabolic syndrome and its components in Puerto Ricans (45-75 year) living in the Greater Boston area... - Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network StudyMireia Junyent
JM USDA HNRCA at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 90:686-94. 2009..Of the environmental factors that determine HDL cholesterol, high-carbohydrate diets have been shown to be associated with low concentrations... - Adaptive genetic variation and heart disease riskLaurence D Parnell
Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
Curr Opin Lipidol 21:116-22. 2010.... - Modulation of gene expression by α-tocopherol and α-tocopheryl phosphate in THP-1 monocytesJean Marc Zingg
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Free Radic Biol Med 49:1989-2000. 2010..It is concluded that αTP and αT influence cell proliferation, ROS production, and Akt(Ser473) phosphorylation in an antagonistic manner, most probably by modulating phosphatidylinositol kinases... - Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal bloodJill L Maron
Department of Pediatrics, Tufts New England Medical Center, Boston, Massachusetts, USA
J Clin Invest 117:3007-19. 2007..Transcriptional analysis of maternal whole blood identifies a unique set of biologically diverse fetal genes and has a multitude of clinical applications... - Associations between genetic polymorphisms of insulin-like growth factor axis genes and risk for age-related macular degenerationChung Jung Chiu
U S Department of Agriculture USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Invest Ophthalmol Vis Sci 52:9099-107. 2011..To investigate whether insulin-like growth factor (IGF) axis genes, together with a novel dietary risk factor, the dietary glycemic index (dGI), and body mass index (BMI) affect the risk for age-related macular degeneration (AMD)... - The modulation of endothelial cell gene expression by green tea polyphenol-EGCGLiping Liu
Vascular Biology Laboratory, JM USDA Human Nutrition Center on Aging at Tufts University, Boston, MA 02111, USA
Mol Nutr Food Res 52:1182-92. 2008..Our data further support earlier observations that the anticancer effect of EGCG is mediated through changes in the expression of genes that are associated with cell proliferation... - Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined dietAron M Troen
Vitamin Metabolism and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA
Age (Dordr) 29:29-39. 2007..Such defined diets can be used to identify lifespan-modifying pathways and specific gene-nutrient interactions in Drosophila... - Adaptive genetic variation and population differencesChao Qiang Lai
Nutrition and Genomics Laboratory, Jean Meyer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
Prog Mol Biol Transl Sci 108:461-89. 2012.... - The SCARB1 gene is associated with lipid response to dietary and pharmacological interventionsYongjun Liu
Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
J Hum Genet 53:709-17. 2008..In summary, our study suggested that the SCARB1 gene may serve as a useful marker that predicts variation in baseline lipid levels, postprandial lipid response, and response to fenofibrate intervention...