Carol Kumamoto

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. pmc Self-regulation of Candida albicans population size during GI colonization
    Sarah Jane White
    Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, United States of America
    PLoS Pathog 3:e184. 2007
  2. pmc Calmodulin binding to Dfi1p promotes invasiveness of Candida albicans
    Talya R Davis
    Program in Molecular Microbiology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America
    PLoS ONE 8:e76239. 2013
  3. pmc Variation in Candida albicans EFG1 expression enables host-dependent changes in colonizing fungal populations
    Jessica V Pierce
    Department of Molecular Biology and Microbiology, School of Medicine, Tufts University, Boston, Massachusetts, USA
    MBio 3:e00117-12. 2012
  4. pmc Functional importance of the DNA binding activity of Candida albicans Czf1p
    Ivana Petrovska
    Graduate Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America
    PLoS ONE 7:e39624. 2012
  5. pmc Experimental annotation of the human pathogen Candida albicans coding and noncoding transcribed regions using high-resolution tiling arrays
    Adnane Sellam
    Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount, Montreal, Quebec, H4P 2R2, Canada
    Genome Biol 11:R71. 2010
  6. pmc Molecular mechanisms of mechanosensing and their roles in fungal contact sensing
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, Tufts University, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Nat Rev Microbiol 6:667-73. 2008
  7. pmc Niche-specific gene expression during C. albicans infection
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, United States
    Curr Opin Microbiol 11:325-30. 2008
  8. pmc Inflammation and gastrointestinal Candida colonization
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, Tufts University, 136 Harrison Ave, Boston, MA 02111, USA
    Curr Opin Microbiol 14:386-91. 2011
  9. pmc Immunosensing during colonization by Candida albicans: does it take a village to colonize the intestine?
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, School of Medicine, Tufts University, Boston, MA 02111, USA
    Trends Microbiol 19:263-7. 2011
  10. ncbi request reprint Alternative Candida albicans lifestyles: growth on surfaces
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111, USA
    Annu Rev Microbiol 59:113-33. 2005

Research Grants

  1. Contact sensing and C. albicans-host interaction
    Carol A Kumamoto; Fiscal Year: 2010
  2. Regulation of Fungal Invasive Growth
    Carol Kumamoto; Fiscal Year: 2005
  3. Regulation of Drug Resistance Genes in C. Albicans
    Carol Kumamoto; Fiscal Year: 2005
  4. Regulation of Drug Resistance Genes in C. Albicans
    Carol Kumamoto; Fiscal Year: 2006
  5. Regulation of Fungal Invasive Growth
    Carol Kumamoto; Fiscal Year: 2006
  6. Regulation of Fungal Invasive Growth
    Carol Kumamoto; Fiscal Year: 2005
  7. Regulation of Drug Resistance Genes in C. Albicans
    Carol Kumamoto; Fiscal Year: 2007
  8. Intestinal colonization by C.albicans and enteric bacteria
    Carol Kumamoto; Fiscal Year: 2007
  9. Regulation of Drug Resistance Genes in C. Albicans
    Carol Kumamoto; Fiscal Year: 2004
  10. Regulation of Fungal Invasive Growth
    Carol Kumamoto; Fiscal Year: 2004

Collaborators

Detail Information

Publications24

  1. pmc Self-regulation of Candida albicans population size during GI colonization
    Sarah Jane White
    Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, United States of America
    PLoS Pathog 3:e184. 2007
    ..Also, different genes are required in different host niches and the pathway(s) that regulates gene expression during host colonization can differ from well-characterized pathways used during laboratory growth...
  2. pmc Calmodulin binding to Dfi1p promotes invasiveness of Candida albicans
    Talya R Davis
    Program in Molecular Microbiology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America
    PLoS ONE 8:e76239. 2013
    ..We propose that conformational changes in Dfi1p in response to environmental conditions encountered during growth allow the protein to bind calmodulin and initiate a signaling cascade that activates Cek1p. ..
  3. pmc Variation in Candida albicans EFG1 expression enables host-dependent changes in colonizing fungal populations
    Jessica V Pierce
    Department of Molecular Biology and Microbiology, School of Medicine, Tufts University, Boston, Massachusetts, USA
    MBio 3:e00117-12. 2012
    ..albicans cells. Altered gene expression in organisms colonizing immunocompromised hosts may begin the transition of C. albicans from a commensal to a pathogen...
  4. pmc Functional importance of the DNA binding activity of Candida albicans Czf1p
    Ivana Petrovska
    Graduate Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America
    PLoS ONE 7:e39624. 2012
    ..Our studies provide the first evidence of a key role for the DNA-binding activity of Czf1p in the morphological yeast-to-hyphal transition triggered by matrix-embedded growth...
  5. pmc Experimental annotation of the human pathogen Candida albicans coding and noncoding transcribed regions using high-resolution tiling arrays
    Adnane Sellam
    Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount, Montreal, Quebec, H4P 2R2, Canada
    Genome Biol 11:R71. 2010
    ..Compared to other model organisms and despite the clinical relevance of the pathogenic yeast Candida albicans, no comprehensive analysis has been done to provide experimental support of its in silico-based genome annotation...
  6. pmc Molecular mechanisms of mechanosensing and their roles in fungal contact sensing
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, Tufts University, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Nat Rev Microbiol 6:667-73. 2008
    ..This Review discusses molecular mechanisms of mechanosensitivity, the proteins involved, such as mechanosensitive ion channels, G-protein-coupled receptors and integrins, and their putative roles in fungal contact sensing...
  7. pmc Niche-specific gene expression during C. albicans infection
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, United States
    Curr Opin Microbiol 11:325-30. 2008
    ..Thus, analysis of C. albicans gene expression illuminates details of host-pathogen interactions and the differences between sites within the host...
  8. pmc Inflammation and gastrointestinal Candida colonization
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, Tufts University, 136 Harrison Ave, Boston, MA 02111, USA
    Curr Opin Microbiol 14:386-91. 2011
    ..Therefore, effects on IL-17 levels may underlie the ability of Candida colonization to enhance inflammation. Because Candida is a frequent colonizer, these effects have the potential to impact many people...
  9. pmc Immunosensing during colonization by Candida albicans: does it take a village to colonize the intestine?
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, School of Medicine, Tufts University, Boston, MA 02111, USA
    Trends Microbiol 19:263-7. 2011
    ..The critical element of this model is that the C. albicans colonizing population is not uniform but is composed of subpopulations of phenotypic variants that are advantageous under different host conditions...
  10. ncbi request reprint Alternative Candida albicans lifestyles: growth on surfaces
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111, USA
    Annu Rev Microbiol 59:113-33. 2005
    ..Recent discoveries have identified factors that regulate these behaviors and revealed the importance of these behaviors for pathogenesis...
  11. ncbi request reprint Candida biofilms
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA
    Curr Opin Microbiol 5:608-11. 2002
    ..The mechanisms by which surface attachment leads to biofilm formation are presently not understood...
  12. pmc A contact-activated kinase signals Candida albicans invasive growth and biofilm development
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 102:5576-81. 2005
    ..Because responding to contact appropriately allows coordinated cellular behavior in a metazoan, commensal C. albicans cells behave like a part of the host, using contact-activated signaling to regulate fungal behavior...
  13. ncbi request reprint Contributions of hyphae and hypha-co-regulated genes to Candida albicans virulence
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA
    Cell Microbiol 7:1546-54. 2005
    ..albicans from the host bloodstream into deeper tissue. Hyphal morphogenesis is thus an integral part of the overall virulence strategy of C. albicans...
  14. pmc Adaptations of Candida albicans for growth in the mammalian intestinal tract
    Ari Rosenbach
    Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA
    Eukaryot Cell 9:1075-86. 2010
    ..albicans cells adopt a particular cell surface when growing within a host in both situations. In addition, transcription factors Cph2p and Tec1p were shown to regulate C. albicans gene expression during intestinal colonization...
  15. pmc Transcriptional regulation of MDR1, encoding a drug efflux determinant, in fluconazole-resistant Candida albicans strains through an Mcm1p binding site
    Perry J Riggle
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Eukaryot Cell 5:1957-68. 2006
    ..Thus, the general transcription factor Mcm1p participates in the regulation of MDR1 expression...
  16. ncbi request reprint Biofilm formation by fluconazole-resistant Candida albicans strains is inhibited by fluconazole
    Igor Bruzual
    Department of Molecular Biology and Microbiology, Tufts University, 136 Harrison Ave, Boston, MA 02111, USA
    J Antimicrob Chemother 59:441-50. 2007
    ..The aim of this study was to determine the effect of the addition of the azole antifungal fluconazole on the initiation of biofilm formation by both drug-susceptible and drug-resistant C. albicans strains...
  17. ncbi request reprint The morphogenetic regulator Czf1p is a DNA-binding protein that regulates white opaque switching in Candida albicans
    Marcelo D Vinces
    Department of Molecular Biology and Microbiology, Tufts University, 136 Harrison Ave, Boston, MA 02111, USA
    Microbiology 153:2877-84. 2007
    ..We also demonstrate that Czf1p binds CZF1 promoter DNA in vitro. Therefore, for the regulation of both contact-dependent filamentation and white-opaque switching, Czf1p and Efg1p have opposing functions...
  18. pmc A Candida albicans cell wall-linked protein promotes invasive filamentation into semi-solid medium
    Paola C Zucchi
    Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA
    Mol Microbiol 76:733-48. 2010
    ..Some Dfi1p molecules become cross-linked to the carbohydrate polymers of the cell wall. Thus, Dfi1p is capable of linking the cell wall to the plasma membrane and cytoplasm...
  19. pmc Expression of the Candida albicans morphogenesis regulator gene CZF1 and its regulation by Efg1p and Czf1p
    Marcelo D Vinces
    Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA
    Eukaryot Cell 5:825-35. 2006
    ..The coupling of environmental cues to the expression of a morphogenetic transcription factor may allow C. albicans to coordinate morphogenesis in response to specific conditions encountered in the human host...
  20. ncbi request reprint A conserved G protein (Drg1p) plays a role in regulation of invasive filamentation in Candida albicans
    Xi Chen
    Department of Molecular Biology and Microbiology, and Genetics Program, Tufts University School of Medicine, Boston, MA 02111, USA
    Microbiology 152:3691-700. 2006
    ..These results implicate Drg1p in the control of invasive filamentation in the laboratory, and in the progression of invasive disease in the host...
  21. pmc Invasive filamentous growth of Candida albicans is promoted by Czf1p-dependent relief of Efg1p-mediated repression
    Angela D Giusani
    Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111, USA
    Genetics 160:1749-53. 2002
    ..We propose that Czf1p interacts with Efg1p, altering its function. The complex regulation of filamentation may reflect the versatility of C. albicans as a pathogen...
  22. pmc Candida albicans biofilms produce antifungal-tolerant persister cells
    Michael D LaFleur
    Department of Biology, Northeastern University, 360 Huntington Ave, 134 Mugar Hall, Boston, MA 02115, USA
    Antimicrob Agents Chemother 50:3839-46. 2006
    ..It remains to be seen whether attachment initiates dormancy that leads to the formation of fungal persisters. This study suggests that persisters may be largely responsible for the multidrug tolerance of fungal biofilms...
  23. ncbi request reprint Chromosome 1 trisomy compromises the virulence of Candida albicans
    Xi Chen
    Department of Molecular Biology and Microbiology and Genetics Program, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Mol Microbiol 51:551-65. 2004
    ..These results suggest that chromosome copy number variation provides a mechanism for genetic variation in this asexual organism...
  24. pmc Microbial pathogenesis: mechanisms of infectious disease
    Vern B Carruthers
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Host Microbe 2:214-9. 2007
    ..Here, we review the presented research that highlights this theme, including studies of both short-term and long-term interactions between microbes and their hosts...

Research Grants20

  1. Contact sensing and C. albicans-host interaction
    Carol A Kumamoto; Fiscal Year: 2010
    ..This research project seeks to understand Candida activities that are necessary for the growth of the organism into host tissue so that future therapies aimed at blocking growth into tissue might be developed. ..
  2. Regulation of Fungal Invasive Growth
    Carol Kumamoto; Fiscal Year: 2005
    ..cerevisiae. Experiments are proposed to identify interactors that bind to the gene products of interest and to elucidate the pathways in which these gene products participate. ..
  3. Regulation of Drug Resistance Genes in C. Albicans
    Carol Kumamoto; Fiscal Year: 2005
    ..The long-term goal of these studies is to contribute to a more informed use of fluconazole with respect to prophylaxis, drug dosage regimens and the development of fluconazole resistant strains. ..
  4. Regulation of Drug Resistance Genes in C. Albicans
    Carol Kumamoto; Fiscal Year: 2006
    ..The long-term goal of these studies is to contribute to a more informed use of fluconazole with respect to prophylaxis, drug dosage regimens and the development of fluconazole resistant strains. ..
  5. Regulation of Fungal Invasive Growth
    Carol Kumamoto; Fiscal Year: 2006
    ..cerevisiae. Experiments are proposed to identify interactors that bind to the gene products of interest and to elucidate the pathways in which these gene products participate. ..
  6. Regulation of Fungal Invasive Growth
    Carol Kumamoto; Fiscal Year: 2005
    ..cerevisiae. Experiments are proposed to identify interactors that bind to the gene products of interest and to elucidate the pathways in which these gene products participate. ..
  7. Regulation of Drug Resistance Genes in C. Albicans
    Carol Kumamoto; Fiscal Year: 2007
    ..The long-term goal of these studies is to contribute to a more informed use of fluconazole with respect to prophylaxis, drug dosage regimens and the development of fluconazole resistant strains. ..
  8. Intestinal colonization by C.albicans and enteric bacteria
    Carol Kumamoto; Fiscal Year: 2007
    ....
  9. Regulation of Drug Resistance Genes in C. Albicans
    Carol Kumamoto; Fiscal Year: 2004
    ..The long-term goal of these studies is to contribute to a more informed use of fluconazole with respect to prophylaxis, drug dosage regimens and the development of fluconazole resistant strains. ..
  10. Regulation of Fungal Invasive Growth
    Carol Kumamoto; Fiscal Year: 2004
    ..cerevisiae. Experiments are proposed to identify interactors that bind to the gene products of interest and to elucidate the pathways in which these gene products participate. ..
  11. Regulation of Drug Resistance Genes in C. Albicans
    Carol Kumamoto; Fiscal Year: 2003
    ..The long-term goal of these studies is to contribute to a more informed use of fluconazole with respect to prophylaxis, drug dosage regimens and the development of fluconazole resistant strains. ..
  12. Regulation of Fungal Invasive Growth
    Carol Kumamoto; Fiscal Year: 2003
    ..cerevisiae. Experiments are proposed to identify interactors that bind to the gene products of interest and to elucidate the pathways in which these gene products participate. ..
  13. Regulation of Fungal Invasive Growth
    Carol Kumamoto; Fiscal Year: 2002
    ..cerevisiae. Experiments are proposed to identify interactors that bind to the gene products of interest and to elucidate the pathways in which these gene products participate. ..