Research Topics
| N I KrinskySummaryAffiliation: Tufts University Country: USA Publications
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Detail Information
Publications
Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal womenXianfeng Zhao
Jean Mayer USDA-Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 83:163-9. 2006....- Human requirements for fat-soluble vitamins, and other things concerning these nutrientsNorman I Krinsky
Department of Biochemistry, Sackler School of Graduate Biomedical Science, School of Medicine and the USDA Human Nutrition Research Center on Aging at Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA
Mol Aspects Med 24:317-24. 2003 - Carotenoid actions and their relation to health and diseaseNorman I Krinsky
Department of Biochemistry, School of Medicine, Tufts University, 136 Harrison Avenue, Boston, MA 02111 1837, USA
Mol Aspects Med 26:459-516. 2005..Until the efficacy and safety of taking supplements containing these nutrients can be determined, current dietary recommendations of diets high in fruits and vegetables are advised... - Biologic mechanisms of the protective role of lutein and zeaxanthin in the eyeNorman I Krinsky
Department of Biochemistry, School of Medicine and the USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111 1837, USA
Annu Rev Nutr 23:171-201. 2003..Although increasing the intake of lutein or zeaxanthin might prove to be protective against the development of age-related macular degeneration, a causative relationship has yet to be experimentally demonstrated... - Carotenoids as antioxidantsN I Krinsky
Department of Biochemistry, School of Medicine, Tufts University, 136 Harrison Avenue, Boston, MA 02111 1837, USA
Nutrition 17:815-7. 2001..His loss has been felt, not only for his scientific contributions but also the warmth and kindness of his personality... - Possible biologic mechanisms for a protective role of xanthophyllsNorman I Krinsky
Department of Biochemistry, School of Medicine, U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1837, USA
J Nutr 132:540S-542S. 2002..Although the evidence is still associative in nature, it is biologically plausible, and may be resolved with additional intervention trials... - Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smokeX D Wang
Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University and Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA
J Natl Cancer Inst 91:60-6. 1999..In this study, we used an animal model system to evaluate the hazard associated with a combination of high-dose beta-carotene supplementation and tobacco smoking... - The effect of alpha-tocopherol on the oxidative cleavage of beta-caroteneK J Yeum
United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Free Radic Biol Med 29:105-14. 2000..In the absence of an antioxidant, beta-carotene is cleaved randomly by enzyme-related radicals to produce beta-apo-carotenoids, and these beta-apo-carotenoids can be oxidized further to retinoic acid via retinal... 
Synergistic interactions of antioxidant nutrients in a biological model systemKyung Jin Yeum
The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
Nutrition 25:839-46. 2009..The antioxidant activity of fat- and water-soluble antioxidant nutrients and their interactions in physiologic concentrations were determined in an in vitro biological model system...- Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasmaKyung Jin Yeum
The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Arch Biochem Biophys 430:97-103. 2004..Revelation of the mechanism of action of antioxidants and their true antioxidant potential will help us to optimize the antioxidant defenses in the body... - Carotenoid-radical interactionsNorman I Krinsky
Department of Biochemistry, School of Medicine, Tufts University, Boston, MA 02111, USA
Biochem Biophys Res Commun 305:754-60. 2003..It is only recently that the biological activity of these breakdown products has begun to be investigated... - The activities of antioxidant nutrients in human plasma depend on the localization of attacking radical speciesKyung Jin Yeum
The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
J Nutr 133:2688-91. 2003..Our study indicates that the antioxidant nutrients present in both the lipid and aqueous compartments can remove free radicals generated in plasma, and their activity depends on the localization of the attacking radical species... - The antioxidant and biological properties of the carotenoidsN I Krinsky
Department of Biochemistry, School of Medicine, Tufts University, Boston, Massachusetts 02111, USA
Ann N Y Acad Sci 854:443-7. 1998..Thus, the biological properties of the carotenoids may be much more related to the products of the interaction of carotenoids with oxidant stress, that is, such breakdown products as apocarotenoids and retinoids... - Beta-carotene and beta-apo-14'-carotenoic acid prevent the reduction of retinoic acid receptor beta in benzo[a]pyrene-treated normal human bronchial epithelial cellsPankaj Prakash
Nutrition and Cancer Biology Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, School of Medicine, Tufts University, Boston, MA 02111, USA
J Nutr 134:667-73. 2004..These observations indicate that the growth inhibitory effects of BC and beta-apo-carotenoic acid are through their conversion to RA and upregulation of RARbeta... - In vitro inhibition of proliferation of estrogen-dependent and estrogen-independent human breast cancer cells treated with carotenoids or retinoidsP Prakash
Department of Biochemistry, School of Medicine, Tufts University, Boston, MA 02111 1837, USA
J Nutr 131:1574-80. 2001..Other mechanistic pathways that are either followed by or concomitant with growth inhibition are possible... - Asymmetric cleavage of beta-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responsesOuliana Ziouzenkova
Cardiovascular Division, Brigham and Women s Hospital, Havard University, Boston, Massachusetts 02115, USA
Mol Endocrinol 21:77-88. 2007..These results also suggest a novel model of molecular endocrinology in which metabolism of a parent compound, beta-carotene, may alternatively activate (9-cisRA) or inhibit (apo14) specific nuclear receptor responses... - Excentric cleavage products of beta-carotene inhibit estrogen receptor positive and negative breast tumor cell growth in vitro and inhibit activator protein-1-mediated transcriptional activationElmi C Tibaduiza
Molecular Pharmacology Research Center, New England Medical Center, Boston, MA 02111, USA
J Nutr 132:1368-75. 2002.... - Bioavailability of synthetic and biosynthetic deuterated lycopene in humansGuangwen Tang
Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr Biochem 16:229-35. 2005..From these preliminary investigations, we find that the bioavailability of synthetic lycopene in oil appears to be about three times higher than that of lycopene from steamed and pureed tomatoes... - Determination of 9-cis beta-carotene and zeta-carotene in biological samplesJian Qin
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr Biochem 19:612-8. 2008..1+/-0.8 and 1.1+/-0.2 nM, and 15.6+/-1.1 nM and 0.2+/-0.1 nmol/g, respectively. zetaC concentrations in the above samples were 54.2+/-7.2 and 8.3+/-1.8 nM, and 49.0+/-3.9 nM and 0.3+/-0.1 nmol/g, respectively... - Enzymatic and oxidative metabolites of lycopeneAna Lucia dos Anjos Ferreira
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP, CP 584, 18618-970, Botucatu, SP, Brazil
J Nutr Biochem 14:531-40. 2003..These results demonstrate that both central and excentric cleavage of lycopene occurs in the rat intestinal mucosa in the presence of soy lipoxygenase... - Total antioxidant performance: a validated fluorescence assay for the measurement of plasma oxidizabilityGiangiacomo Beretta
Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, 20143 Milan, Italy
Anal Biochem 354:290-8. 2006..93, P<0.01). The results confirm that the TAP assay is suitable to measure the antioxidant activity of plasma antioxidants localized in both the lipophilic and hydrophilic compartments... - (-)-Epigallocatechin-3-gallate prevents oxidative damage in both the aqueous and lipid compartments of human plasmaGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Milan, Italy
Biochem Biophys Res Commun 302:409-14. 2003..Further, ESR experiments confirmed that EGCG recycled alpha-tocopherol through a H-transfer mechanism at the aqueous/lipid interface affording an additional protective mechanism to the lipid compartment of plasma... - Doxorubicin as an antioxidant: maintenance of myocardial levels of lycopene under doxorubicin treatmentAna Lucia Anjos Ferreira
Department of Internal Medicine, Botucatu Faculty of Medicine, UNESP, Sao Paulo State University, CEP 18618 970, Botucatu, SP, Brazil
Free Radic Biol Med 43:740-51. 2007.... - Enzymatic and oxidative metabolites of lycopeneAna Lucia dos Anjos Ferreira
Faculdade de Medicina de Botucatu, Unviersidade Estadual Paulista (UNESP, CP 584, Botucatu, SP 18618-970, Brazil
J Nutr Biochem 15:493-502. 2004..These results demonstrate that both central and excentric cleavage of lycopene occurs in the rat intestinal mucosa in the presence of soy lipoxygenase...