N I Krinsky

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women
    Xianfeng Zhao
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 83:163-9. 2006
  2. ncbi request reprint Human requirements for fat-soluble vitamins, and other things concerning these nutrients
    Norman I Krinsky
    Department of Biochemistry, Sackler School of Graduate Biomedical Science, School of Medicine and the USDA Human Nutrition Research Center on Aging at Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA
    Mol Aspects Med 24:317-24. 2003
  3. ncbi request reprint Carotenoid actions and their relation to health and disease
    Norman I Krinsky
    Department of Biochemistry, School of Medicine, Tufts University, 136 Harrison Avenue, Boston, MA 02111 1837, USA
    Mol Aspects Med 26:459-516. 2005
  4. ncbi request reprint Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye
    Norman I Krinsky
    Department of Biochemistry, School of Medicine and the USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111 1837, USA
    Annu Rev Nutr 23:171-201. 2003
  5. ncbi request reprint Carotenoids as antioxidants
    N I Krinsky
    Department of Biochemistry, School of Medicine, Tufts University, 136 Harrison Avenue, Boston, MA 02111 1837, USA
    Nutrition 17:815-7. 2001
  6. ncbi request reprint Possible biologic mechanisms for a protective role of xanthophylls
    Norman I Krinsky
    Department of Biochemistry, School of Medicine, U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1837, USA
    J Nutr 132:540S-542S. 2002
  7. ncbi request reprint Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke
    X D Wang
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University and Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA
    J Natl Cancer Inst 91:60-6. 1999
  8. ncbi request reprint The effect of alpha-tocopherol on the oxidative cleavage of beta-carotene
    K J Yeum
    United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 29:105-14. 2000
  9. doi request reprint Synergistic interactions of antioxidant nutrients in a biological model system
    Kyung Jin Yeum
    The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Nutrition 25:839-46. 2009
  10. ncbi request reprint Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma
    Kyung Jin Yeum
    The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Arch Biochem Biophys 430:97-103. 2004

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women
    Xianfeng Zhao
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 83:163-9. 2006
    ..Carotenoids could be a part of a protective strategy to minimize oxidative damage in vulnerable populations, such as the elderly...
  2. ncbi request reprint Human requirements for fat-soluble vitamins, and other things concerning these nutrients
    Norman I Krinsky
    Department of Biochemistry, Sackler School of Graduate Biomedical Science, School of Medicine and the USDA Human Nutrition Research Center on Aging at Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA
    Mol Aspects Med 24:317-24. 2003
  3. ncbi request reprint Carotenoid actions and their relation to health and disease
    Norman I Krinsky
    Department of Biochemistry, School of Medicine, Tufts University, 136 Harrison Avenue, Boston, MA 02111 1837, USA
    Mol Aspects Med 26:459-516. 2005
    ..Until the efficacy and safety of taking supplements containing these nutrients can be determined, current dietary recommendations of diets high in fruits and vegetables are advised...
  4. ncbi request reprint Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye
    Norman I Krinsky
    Department of Biochemistry, School of Medicine and the USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111 1837, USA
    Annu Rev Nutr 23:171-201. 2003
    ..Although increasing the intake of lutein or zeaxanthin might prove to be protective against the development of age-related macular degeneration, a causative relationship has yet to be experimentally demonstrated...
  5. ncbi request reprint Carotenoids as antioxidants
    N I Krinsky
    Department of Biochemistry, School of Medicine, Tufts University, 136 Harrison Avenue, Boston, MA 02111 1837, USA
    Nutrition 17:815-7. 2001
    ..His loss has been felt, not only for his scientific contributions but also the warmth and kindness of his personality...
  6. ncbi request reprint Possible biologic mechanisms for a protective role of xanthophylls
    Norman I Krinsky
    Department of Biochemistry, School of Medicine, U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1837, USA
    J Nutr 132:540S-542S. 2002
    ..Although the evidence is still associative in nature, it is biologically plausible, and may be resolved with additional intervention trials...
  7. ncbi request reprint Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke
    X D Wang
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University and Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA
    J Natl Cancer Inst 91:60-6. 1999
    ..In this study, we used an animal model system to evaluate the hazard associated with a combination of high-dose beta-carotene supplementation and tobacco smoking...
  8. ncbi request reprint The effect of alpha-tocopherol on the oxidative cleavage of beta-carotene
    K J Yeum
    United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 29:105-14. 2000
    ..In the absence of an antioxidant, beta-carotene is cleaved randomly by enzyme-related radicals to produce beta-apo-carotenoids, and these beta-apo-carotenoids can be oxidized further to retinoic acid via retinal...
  9. doi request reprint Synergistic interactions of antioxidant nutrients in a biological model system
    Kyung Jin Yeum
    The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Nutrition 25:839-46. 2009
    ..The antioxidant activity of fat- and water-soluble antioxidant nutrients and their interactions in physiologic concentrations were determined in an in vitro biological model system...
  10. ncbi request reprint Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma
    Kyung Jin Yeum
    The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Arch Biochem Biophys 430:97-103. 2004
    ..Revelation of the mechanism of action of antioxidants and their true antioxidant potential will help us to optimize the antioxidant defenses in the body...
  11. ncbi request reprint Carotenoid-radical interactions
    Norman I Krinsky
    Department of Biochemistry, School of Medicine, Tufts University, Boston, MA 02111, USA
    Biochem Biophys Res Commun 305:754-60. 2003
    ..It is only recently that the biological activity of these breakdown products has begun to be investigated...
  12. ncbi request reprint The activities of antioxidant nutrients in human plasma depend on the localization of attacking radical species
    Kyung Jin Yeum
    The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Nutr 133:2688-91. 2003
    ..Our study indicates that the antioxidant nutrients present in both the lipid and aqueous compartments can remove free radicals generated in plasma, and their activity depends on the localization of the attacking radical species...
  13. ncbi request reprint The antioxidant and biological properties of the carotenoids
    N I Krinsky
    Department of Biochemistry, School of Medicine, Tufts University, Boston, Massachusetts 02111, USA
    Ann N Y Acad Sci 854:443-7. 1998
    ..Thus, the biological properties of the carotenoids may be much more related to the products of the interaction of carotenoids with oxidant stress, that is, such breakdown products as apocarotenoids and retinoids...
  14. ncbi request reprint Beta-carotene and beta-apo-14'-carotenoic acid prevent the reduction of retinoic acid receptor beta in benzo[a]pyrene-treated normal human bronchial epithelial cells
    Pankaj Prakash
    Nutrition and Cancer Biology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, School of Medicine, Tufts University, Boston, MA 02111, USA
    J Nutr 134:667-73. 2004
    ..These observations indicate that the growth inhibitory effects of BC and beta-apo-carotenoic acid are through their conversion to RA and upregulation of RARbeta...
  15. ncbi request reprint In vitro inhibition of proliferation of estrogen-dependent and estrogen-independent human breast cancer cells treated with carotenoids or retinoids
    P Prakash
    Department of Biochemistry, School of Medicine, Tufts University, Boston, MA 02111 1837, USA
    J Nutr 131:1574-80. 2001
    ..Other mechanistic pathways that are either followed by or concomitant with growth inhibition are possible...
  16. ncbi request reprint Asymmetric cleavage of beta-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responses
    Ouliana Ziouzenkova
    Cardiovascular Division, Brigham and Women s Hospital, Havard University, Boston, Massachusetts 02115, USA
    Mol Endocrinol 21:77-88. 2007
    ..These results also suggest a novel model of molecular endocrinology in which metabolism of a parent compound, beta-carotene, may alternatively activate (9-cisRA) or inhibit (apo14) specific nuclear receptor responses...
  17. ncbi request reprint Excentric cleavage products of beta-carotene inhibit estrogen receptor positive and negative breast tumor cell growth in vitro and inhibit activator protein-1-mediated transcriptional activation
    Elmi C Tibaduiza
    Molecular Pharmacology Research Center, New England Medical Center, Boston, MA 02111, USA
    J Nutr 132:1368-75. 2002
    ....
  18. ncbi request reprint Bioavailability of synthetic and biosynthetic deuterated lycopene in humans
    Guangwen Tang
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 16:229-35. 2005
    ..From these preliminary investigations, we find that the bioavailability of synthetic lycopene in oil appears to be about three times higher than that of lycopene from steamed and pureed tomatoes...
  19. doi request reprint Determination of 9-cis beta-carotene and zeta-carotene in biological samples
    Jian Qin
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 19:612-8. 2008
    ..1+/-0.8 and 1.1+/-0.2 nM, and 15.6+/-1.1 nM and 0.2+/-0.1 nmol/g, respectively. zetaC concentrations in the above samples were 54.2+/-7.2 and 8.3+/-1.8 nM, and 49.0+/-3.9 nM and 0.3+/-0.1 nmol/g, respectively...
  20. ncbi request reprint Enzymatic and oxidative metabolites of lycopene
    Ana Lucia dos Anjos Ferreira
    Faculdade de Medicina de Botucatu, Universidade Estadual Paulista UNESP, CP 584, 18618 970, Botucatu, SP, Brazil
    J Nutr Biochem 14:531-40. 2003
    ..These results demonstrate that both central and excentric cleavage of lycopene occurs in the rat intestinal mucosa in the presence of soy lipoxygenase...
  21. ncbi request reprint Total antioxidant performance: a validated fluorescence assay for the measurement of plasma oxidizability
    Giangiacomo Beretta
    Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, 20143 Milan, Italy
    Anal Biochem 354:290-8. 2006
    ..93, P<0.01). The results confirm that the TAP assay is suitable to measure the antioxidant activity of plasma antioxidants localized in both the lipophilic and hydrophilic compartments...
  22. ncbi request reprint (-)-Epigallocatechin-3-gallate prevents oxidative damage in both the aqueous and lipid compartments of human plasma
    Giancarlo Aldini
    Istituto Chimico Farmaceutico Tossicologico, University of Milan, Milan, Italy
    Biochem Biophys Res Commun 302:409-14. 2003
    ..Further, ESR experiments confirmed that EGCG recycled alpha-tocopherol through a H-transfer mechanism at the aqueous/lipid interface affording an additional protective mechanism to the lipid compartment of plasma...
  23. ncbi request reprint Doxorubicin as an antioxidant: maintenance of myocardial levels of lycopene under doxorubicin treatment
    Ana Lucia Anjos Ferreira
    Department of Internal Medicine, Botucatu Faculty of Medicine, UNESP, Sao Paulo State University, CEP 18618 970, Botucatu, SP, Brazil
    Free Radic Biol Med 43:740-51. 2007
    ....
  24. ncbi request reprint Enzymatic and oxidative metabolites of lycopene
    Ana Lucia dos Anjos Ferreira
    Faculdade de Medicina de Botucatu, Unviersidade Estadual Paulista UNESP, CP 584, Botucatu, SP 18618 970, Brazil
    J Nutr Biochem 15:493-502. 2004
    ..These results demonstrate that both central and excentric cleavage of lycopene occurs in the rat intestinal mucosa in the presence of soy lipoxygenase...