Research Topics
| Richard KarasSummaryAffiliation: Tufts Medical Center Country: USA Publications
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Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3Johnthan Gordon
Department of Biochemistry and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
BMC Biochem 12:54. 2011..Little is known about the molecular architecture of the striatin complex and the regulation of these sterile 20-like kinases...
Niacin's role in the statin eraErica L Brooks
Preventive Cardiology Center, Tufts Medical Center, Division of Cardiology, Department of Medicine, 800 Washington Street, Box 80, Boston, MA 02111, USA
Expert Opin Pharmacother 11:2291-300. 2010..Niacin is the most effective agent available at present to increase HDL-C...
Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: the OCEANS studyRichard H Karas
Division of Cardiology, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
Am J Cardiovasc Drugs 8:69-81. 2008..This fact has focused increased attention on treating abnormalities of non-high-density lipoprotein-cholesterol (non-HDL-C), HDL-C, and triglycerides in national guidelines and has intensified interest in combination therapy...- Niacin and laropiprantS Sanyal
Division of Cardiology, Department of Medicine, Preventive Cardiology Center, Tufts Medical Center, Boston, MA 02111, USA
Drugs Today (Barc) 46:371-8. 2010..This paper reviews the data suggesting the importance of raising HDL with niacin, describes the pharmacology of the drug, and examines the potential beneficial effects of combining niacin with laropiprant... - Assessment of peripheral vascular endothelial function in the ambulatory settingJeffrey T Kuvin
Department of Medicine Division of Cardiology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Vasc Med 12:13-6. 2007..In conclusion, these data suggest that peripheral vascular endothelial function testing is feasible in ambulatory patients, and this is an important next step in bringing this technology to clinical applicability... - Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitudeJeffrey T Kuvin
Department of Medicine, Division of Cardiology, Tufts New England Medical Center Hospitals, Tufts University School of Medicine, Boston, MA 02111, USA
Am Heart J 146:168-74. 2003..We evaluated the relationship between changes in PWA of the finger and peripheral endothelial function... - Abnormal vascular function and hypertension in mice deficient in estrogen receptor betaYan Zhu
Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
Science 295:505-8. 2002..Furthermore, ERbeta-deficient mice develop sustained systolic and diastolic hypertension as they age. These data support an essential role for ERbeta in the regulation of vascular function and blood pressure... - Effects of extended-release niacin on lipoprotein particle size, distribution, and inflammatory markers in patients with coronary artery diseaseJeffrey T Kuvin
The Division of Cardiology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts, USA
Am J Cardiol 98:743-5. 2006..The effect of altering lipoprotein particle distribution and inflammatory markers on surrogate markers of atherosclerosis and clinical cardiovascular events in this population remains unclear... - Assessment of vascular endothelial function with peripheral arterial tonometry: information at your fingertips?Eshan A Patvardhan
Vascular Function Study Group, Department of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA
Cardiol Rev 18:20-8. 2010..This review highlights techniques for assessing endothelial function, focusing on a novel method of determining peripheral vascular reactivity via arterial tonometry... - Clinical utility of endothelial function testing: ready for prime time?Jeffrey T Kuvin
Division of Cardiology, Tufts New England Medical Center, 750 Washington St, Box 315, Boston, MA 02111, USA
Circulation 107:3243-7. 2003 - Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradationCameron Donaldson
Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
Circ Res 104:265-75, 11p following 275. 2009..These data support that E2 reduces pressure overload induced hypertrophy by an ER-dependent mechanism that increases CnA degradation, unveiling a novel mechanism by which E2 and ERs regulate pathological LV and cardiomyocyte growth... - Modestly overweight women have vascular endothelial dysfunctionAyan R Patel
Division of Cardiology, Tufts Medical Center, Boston, Massachusetts, USA
Clin Cardiol 32:269-73. 2009.... - Modulator recognition factor 1, an AT-rich interaction domain family member, is a novel corepressor for estrogen receptor alphaSerban P Georgescu
Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Mol Endocrinol 19:2491-501. 2005..These data identify MRF1 as a repressor of ERalpha-mediated transcriptional activation and support a role for MRF1 in regulating ER-dependent gene expression in cardiovascular and other cells... - Safety of lovastatin/extended release niacin compared with lovastatin alone, atorvastatin alone, pravastatin alone, and simvastatin alone (from the United States Food and Drug Administration adverse event reporting system)Alawi A Alsheikh Ali
Molecular Cardiology Research Institute and Division of Cardiology, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
Am J Cardiol 99:379-81. 2007.... - MAP kinase mediates growth factor-induced nuclear translocation of estrogen receptor alphaQing Lu
Molecular Cardiology Research Institute, Department of Medicine, and Division of Cardiology, New England Medical Center Hospitals, Tufts University School of Medicine, 750 Washington Street, P O Box 80, 02111, Boston, MA, USA
FEBS Lett 516:1-8. 2002.... - Evaluation of peripheral vascular endothelial function with a portable ultrasound deviceAlawi A Alsheikh-Ali
Division of Cardiology, Department of Medicine, Tufts-New England Medical Center Boston, Massachusetts 02111, USA
Echocardiography 23:623-6. 2006..These findings support the feasibility of noninvasive evaluation of peripheral endothelial function in the ambulatory setting... - Pulse wave amplitude is associated with brachial artery diameter: implications for gender differences in microvascular functionKevin S Heffernan
Vascular Function Study Group, Department of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA
Vasc Med 15:39-45. 2010..In conclusion, PWA-RHI obtained from PAT is associated with BAD. Studies examining gender differences in microvascular endothelial function with PAT may need to correct for BAD as a potential confounder... - Peripheral arterial tonometry for risk stratification in men with coronary artery diseaseKevin S Heffernan
The Vascular Function Study Group Division of Cardiology, Tufts Medical Center, Boston, Massachusetts 02111, USA
Clin Cardiol 33:94-8. 2010..Identification of a simple, noninvasive tool that allows for detection of high-risk CAD patients and can be applied in large populations and clinical settings would prove valuable... - Rapid progress for non-nuclear estrogen receptor signalingMichael E Mendelsohn
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
J Clin Invest 120:2277-9. 2010.... - Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in womenInga Peter
Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Am J Hypertens 18:1388-95. 2005..Given sex-based differences in cardiac structure and remodeling, we hypothesized that variation in estrogen pathway genes might be associated with alteration of LV structure... - Elevated soluble fms-like tyrosine kinase-1 levels in acute coronary occlusionNavin K Kapur
Molecular Cardiology Research Institute, Division of Cardiology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
Arterioscler Thromb Vasc Biol 31:443-50. 2011..Early recognition of an acute coronary occlusion (ACO) improves clinical outcomes. Soluble fms-like tyrosine kinase-1 (sFLT1) is an endothelium-derived protein induced by hypoxia. We tested whether sFLT1 levels are elevated in ACO... - Usefulness of soluble endoglin as a noninvasive measure of left ventricular filling pressure in heart failureNavin K Kapur
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
Am J Cardiol 106:1770-6. 2010..sEng levels also decreased in association with a reduced cardiac filling pressure after diuresis. These findings have identified circulating sEng as a sensitive measure of elevated left heart filling pressures... - Relation of pulse pressure to blood pressure response to exercise in patients with hypertrophic cardiomyopathyKevin S Heffernan
Hypertrophic Cardiomyopathy Center, Division of Cardiology, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
Am J Cardiol 107:600-3. 2011..24 to 18.2, p <0.05). In conclusion, elevations in PP at rest might identify patients with HC at a greater risk of having an ABPR during exercise... - Elevated augmentation index derived from peripheral arterial tonometry is associated with abnormal ventricular-vascular couplingKevin S Heffernan
The Vascular Function Study Group, Division of Cardiology, Tufts Medical Center, Molecular Cardiology Research Institute, Boston, MA 02111, USA
Clin Physiol Funct Imaging 30:313-7. 2010..Little is known regarding the physiologic correlates of AIx derived from PAT. In this study, we investigated the relation of PAT-AIx with measures of ventricular-vascular coupling... - Risk of adverse events with concomitant use of atorvastatin or simvastatin and glucose-lowering drugs (thiazolidinediones, metformin, sulfonylurea, insulin, and acarbose)Alawi A Alsheikh-Ali
Department of Medicine, Division of Cardiology, Preventive Cardiology Center, Boston, Massachusetts 02111, USA
Am J Cardiol 89:1308-10. 2002 - The relationship of statins to rhabdomyolysis, malignancy, and hepatic toxicity: evidence from clinical trialsAlawi A Alsheikh-Ali
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
Curr Atheroscler Rep 11:100-4. 2009.... - Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita miceHo Jin Park
Tufts Medical Center, Molecular Cardiology Research Institute, 750 Washington St, Box 8486, Boston, MA 02111, USA
Circ Res 105:287-94. 2009..Sterol regulatory element binding protein-1 (SREBP-1) is a lipid-sensitive transcription factor... - Regulation of estrogen receptor alpha-mediated transcription by a direct interaction with protein phosphatase 2AQing Lu
Department of Medicine and Molecular Cardiology Research Institute, New England Medical Center Hospitals, Inc, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 278:4639-45. 2003.... - Peripheral vascular endothelial function correlates with exercise capacity in cardiac transplant recipientsAyan R Patel
Division of Cardiology/Department of Medicine, Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA
Am J Cardiol 91:897-9. 2003 - Endothelium-dependent vasodilation is associated with exercise capacity in smokers and non-smokersKevin S Heffernan
Vascular Function Study Group, Tufts Medical Center, Boston, MA 02111, USA
Vasc Med 15:119-25. 2010..Future research is needed to examine if improving endothelial function will lead to concomitant increases in exercise capacity in chronic smokers... - Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levelsInga Peter
Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
J Clin Endocrinol Metab 93:2779-85. 2008..To explore potential mechanisms by which these gene variants may contribute to cardiovascular disease, we tested the hypothesis that the polymorphisms were associated with endogenous steroid hormone levels... - Parasympathetic response in chick myocytes and mouse heart is controlled by SREBPHo Jin Park
Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Clin Invest 118:259-71. 2008..These results demonstrate a relationship between lipid metabolism and parasympathetic response that may play a role in arrhythmogenesis... - High-density lipoprotein cholesterol and coronary heart diseaseChristine E Young
Department of Medicine/Division of Cardiology, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
Cardiol Rev 12:107-19. 2004..This review highlights the role of HDL in coronary heart disease, from basic mechanisms of action to recent clinical trial results... - Effect of atenolol vs metoprolol succinate on vascular function in patients with hypertensionKevin S Heffernan
Vascular Function Study Group, Department of Medicine, Division of Cardiology, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
Clin Cardiol 34:39-44. 2011..We evaluated the effect of atenolol vs metoprolol succinate on vascular function in patients with essential hypertension... - Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trialsAlawi A Alsheikh Ali
Molecular Cardiology Research Institute and Division of Cardiology, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Am Coll Cardiol 50:409-18. 2007..We sought to assess the relationship between the magnitude of low-density lipoprotein cholesterol (LDL-C) lowering and rates of elevated liver enzymes, rhabdomyolysis, and cancer... - Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha geneInga Peter
Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA 02111, USA
Hypertension 49:1000-6. 2007..Understanding the mechanisms predisposing to unfavorable LV remodeling of the heart with advancing age may aid in the discovery of new therapeutic targets for the prevention of heart failure... - Estrogen receptors alpha and beta mediate distinct pathways of vascular gene expression, including genes involved in mitochondrial electron transport and generation of reactive oxygen speciesRaegan O'Lone
Department of Biology, Boston University, Boston, Massachusetts 02215, USA
Mol Endocrinol 21:1281-96. 2007..Overall, these findings provide a foundation for understanding the molecular basis for estrogen effects on vasculature gene expression... - The safety of niacin in the US Food and Drug Administration adverse event reporting databaseAlawi A Alsheikh-Ali
Institute for Clinical Research and Health Policy Studies and Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Am J Cardiol 101:9B-13B. 2008..These analyses should encourage the use of niacin-ER in patients at high risk for cardiovascular disease, as recommended by current national guidelines for cardiovascular prevention... - 17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overloadRichard D Patten
Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
J Card Fail 14:245-53. 2008..However, E2 decreases hypertrophy in pressure overload models. We hypothesized that the effect of estrogen on cardiac hypertrophy was dependent on the type of hypertrophic stimulus... - Baseline and on-treatment high-density lipoprotein cholesterol and the risk of cancer in randomized controlled trials of lipid-altering therapyHaseeb Jafri
Molecular Cardiology Research Institute, Department of Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Am Coll Cardiol 55:2846-54. 2010..We sought to examine the relationship between high-density lipoprotein cholesterol (HDL-C) levels and the risk of the development of cancer in large randomized controlled trials (RCTs) of lipid-altering interventions... - Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alphaQing Lu
Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 101:17126-31. 2004..Furthermore, by demonstrating independent regulation of nongenomic vs. genomic ER-dependent signaling, these findings provide conceptual support for the potential development of "pathway-specific" selective ER modulators... - Effects of statins on nonlipid serum markers associated with cardiovascular disease: a systematic reviewEthan M Balk
Tufts University School of Medicine and Tufts-New England Medical Center, Boston, Massachusetts 02111, USA
Ann Intern Med 139:670-82. 2003..Overall, however, available data are insufficient to support recommendations for using nonlipid serum markers in decisions regarding statin therapy for individual patients... - The effects of LDL reduction and HDL augmentation on physiologic and inflammatory markersJeffrey T Kuvin
Department of Medicine, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA
Curr Opin Cardiol 18:295-300. 2003..New therapeutic strategies are being designed to inhibit specific aspects of the inflammatory system that contribute to the initiation and progression of atherosclerosis... - A novel mechanism for the beneficial vascular effects of high-density lipoprotein cholesterol: enhanced vasorelaxation and increased endothelial nitric oxide synthase expressionJeffrey T Kuvin
Department of Medicine, New England Medical Center Hospitals, Inc, Tufts University School of Medicine, Boston, Mass, USA
Am Heart J 144:165-72. 2002.... - Relation between high-density lipoprotein cholesterol and peripheral vasomotor functionJeffrey T Kuvin
Department of Medicine Division of Cardiology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Am J Cardiol 92:275-9. 2003..These data suggest that impaired endothelial function associated with low HDL cholesterol may be an additional, previously unrecognized mechanism contributing to the increased risk of atherosclerosis in these patients... - Molecular and cellular basis of cardiovascular gender differencesMichael E Mendelsohn
Molecular Cardiology Research Institute, Department of Medicine, and Division of Cardiology, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, MA 02111, USA
Science 308:1583-7. 2005.... - Extent to which accepted serum lipid goals are achieved in a contemporary general medical population with coronary heart disease risk equivalentsAlawi A Alsheikh-Ali
Division of Cardiology and Molecular Cardiology Research Institute, Tufts-New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
Am J Cardiol 98:1231-3. 2006..5% were taking fibrates and 8.2% niacin. In conclusion, the present analysis highlights the dramatic need to further improve preventive measures in a substantial proportion of high-risk patients with CHD risk equivalents... - Peripheral vascular endothelial function correlates with exercise capacity in womenAyan R Patel
Division of Cardiology, Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
Clin Cardiol 28:433-6. 2005..These observations raise the possibility that the relationship between endothelial function and exercise capacity in women may differ from that in men... - Estrogen replacement and cardiomyocyte protectionRichard D Patten
Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA 02111, USA
Trends Cardiovasc Med 16:69-75. 2006..Further work is necessary to more completely understand the complex effects of sex hormones on cardiomyocyte biology... - Differential effects of statins (pravastatin or simvastatin) on ventricular ectopic complexes: Galpha(i2), a possible molecular marker for ventricular irritabilityC Michael Welzig
Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
Am J Cardiol 105:1112-7. 2010.... - Statin-associated myopathyPaul D Thompson
Preventive Cardiology and Cardiovascular Research, Division of Cardiology, Hartford Hospital, Hartford, Conn 06102, USA
JAMA 289:1681-90. 2003..How statins injure skeletal muscle is not clear, although recent evidence suggests that statins reduce the production of small regulatory proteins that are important for myocyte maintenance... - Adverse events with concomitant use of simvastatin or atorvastatin and thiazolidinedionesAlawi A Alsheikh-Ali
Department of Medicine, Division of Cardiology, Preventive Cardiology Center, Tufts-New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
Am J Cardiol 93:1417-8, A9. 2004..1 times more likely to list rosiglitazone or pioglitazone as a concomitant medication compared with simvastatin-associated adverse event reports... - Comparison of the frequency of adverse events in patients treated with atorvastatin or simvastatinHeather M Abourjaily
Department of Pharmacy, Tufts-New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
Am J Cardiol 91:999-1002, A7. 2003 - Vascular endothelial dysfunction is associated with reversible myocardial perfusion defects in the absence of obstructive coronary artery diseasePrem Soman
Division of Cardiology, Tufts New England Medical Center, Boston, Mass, USA
J Nucl Cardiol 13:756-60. 2006..Recent evidence suggests that coronary endothelial dysfunction might play a role in the pathogenesis of these defects... - Peripheral vascular endothelial function in patients with hypertrophic cardiomyopathyKevin S Heffernan
The Vascular Function Study Group, The Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, Massachusetts, USA
Am J Cardiol 105:112-5. 2010..Patients with HC have impaired peripheral conduit vessel endothelial function, and the magnitude of impairment is similar to that seen in older patients with advanced CAD... - Comparison of flow-mediated dilatation of the brachial artery in coronary patients with low-density lipoprotein cholesterol levels <80 mg/dl versus patients with levels 80 to 100 mg/dlJeffrey T Kuvin
Division of Cardiology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Am J Cardiol 95:93-5. 2005..These data support recent reports that decreasing levels of LDL cholesterol below those currently recommended provides additional benefits and suggest that this benefit may be due in part to increased endothelial function... - Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injuryGary Pare
Molecular Cardiology Research Institute, New England Medical Center, Boston, Massachusetts, USA
Circ Res 90:1087-92. 2002..These data demonstrate that estrogen receptor-alpha mediates the protective effects of estrogen on the response to vascular injury... - Gender-based differences in brachial artery flow-mediated vasodilation as an indicator of significant coronary artery diseaseAyan R Patel
The Division of Cardiology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts, USA
Am J Cardiol 96:1223-6. 2005..In studies using FMD to evaluate cardiovascular risk, different standards should be applied for women and men... - Adverse events with concomitant amiodarone and statin therapyAlawi A Alsheikh-Ali
Department of Medicine, Division of Cardiology, Preventive Cardiology Center, Tufts-New England Medical Center, Boston, MA 02111, USA
Prev Cardiol 8:95-7. 2005..Use of a statin not metabolized through the cytochrome P450-3A4 system may be appropriate in this setting... - Statin use is associated with enhanced collateralization of severely diseased coronary arteriesIsaac Pourati
Preventive Cardiology Center, Division of Cardiology, and Department of Medicine, New England Medical Center Hospitals, Boston, Mass, USA
Am Heart J 146:876-81. 2003..05). CONCLUSIONS: Statin therapy is associated with enhanced coronary collateral formation in patients with severely diseased coronary arteries... - Renal actions of RGS2 control blood pressureSusan B Gurley
Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA
J Am Soc Nephrol 21:1847-51. 2010..These data support a critical role for the renal epithelium and/or vasculature as the final determinants of the intra-arterial pressure in hypertension... - Hormone replacement therapy and the cardiovascular system lessons learned and unanswered questionsPamela Ouyang
Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Am Coll Cardiol 47:1741-53. 2006..This review outlines the lessons learned from the basic science, animal, observational, and randomized trials, and then summarizes yet-unanswered questions of hormone therapy and cardiovascular risk... - High-density lipoprotein cholesterol-raising strategiesJeffrey T Kuvin
Division of Cardiology, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine Boston, Massachusettes 0211, USA
J Cardiovasc Pharmacol 47:196-204. 2006..Recent findings regarding the role of HDL-C in cholesterol metabolism offer new strategies designed to target atherosclerosis. This review highlights the utility of existing HDL-C-raising strategies and examines new potential therapies... - Relative safety of gemfibrozil and fenofibrate in the absence of concomitant cerivastatin useNoa Holoshitz
Molecular Cardiology Research Institute and Division of Cardiology, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
Am J Cardiol 101:95-7. 2008..Rates of all AERs and serious AERs were higher with fenofibrate, but well within the range observed with commonly used lipid-altering medications... - Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart StudyInga Peter
Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Massachusetts Institute of Technology, Cambridge, MA, USA
J Hypertens 23:2193-200. 2005..To examine the association between variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in men and women... - Association between estrogen receptor alpha gene variation and cardiovascular diseaseAmanda M Shearman
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Mass 02139, USA
JAMA 290:2263-70. 2003..Relatively little is known, however, about the impact of genetic variation in estrogen receptor alpha (ESR1) on CVD risk... - Comparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs simvastatin monotherapy in patients with increased non-HDL cholesterol (from the SEACOAST I study)Christie M Ballantyne
Baylor College of Medicine and Methodist DeBakey Heart and Vascular Center, Houston, Texas, USA
Am J Cardiol 101:1428-36. 2008..In conclusion, this study showed that NER/S provided additional clinically relevant improvements in multiple lipid parameters and was safe and well tolerated... - Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart StudySerkalem Demissie
Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, TE425 Boston, MA 02118, USA
Atherosclerosis 185:210-8. 2006..30T-c.454-397T-c.454-351A haplotype (frequency, 46%), where L and S are long and short TA repeats. Our results suggest that common ESR1 polymorphisms have a significant effect on lipoprotein metabolism in women... - p38 mitogen-activated protein kinase activates eNOS in endothelial cells by an estrogen receptor alpha-dependent pathway in response to black tea polyphenolsElad Anter
Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
Circ Res 96:1072-8. 2005..These findings suggest p38 MAP kinase-mediated eNOS activation requires ERalpha and these data uncover a new mechanism of ERalpha activation that has broad implications for NO bioactivity and endothelial cell phenotype... - Is the WHI relevant to HRT started in the perimenopause?S Mitchell Harman
Kronos Longevity Research Institute, Phoenix, AZ, USA
Endocrine 24:195-202. 2004..Furthermore, animal and clinical evidence supports the use of lower doses of estrogen than were employed in the WHI in older/longer postmenopausal women... - Effects of statins on vascular structure and function: a systematic reviewEthan M Balk
Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies
Am J Med 117:775-90. 2004..Statins also improve measures of vascular function, which may contribute to their clinical benefits. There is insufficient evidence to suggest that individual statins differ in their vascular effects... - Risk of adverse events with fibratesAlawi A Alsheikh-Ali
Molecular Cardiology Research Institute, Department of Medicine, Division of Cardiology, Tufts-New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Am J Cardiol 94:935-8. 2004..This difference was especially noticeable in patients taking the combination of gemfibrozil and a statin, particularly cerivastatin... - 17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signalingRichard D Patten
Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center, 750 Washington St, Boston MA 02111, USA
Circ Res 95:692-9. 2004.... - Current controversies regarding the cardiovascular effects of hormone therapyRichard H Karas
Department of Medicine, Division of Cardiology, Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA
Clin Obstet Gynecol 47:489-99. 2004 - High-density lipoprotein cholesterol in the cardiovascular equation: does the "good" still count?Alawi A Alsheikh-Ali
Molecular Cardiology Research Institute, Division of Cardiology, Tufts New England Medical Center, Tufts University School of Medicine, 750 Washington Street, Box 80, Boston, MA 02111, USA
Atherosclerosis 180:217-23. 2005.... - Statins, low-density lipoprotein cholesterol, and risk of cancerAlawi A Alsheikh-Ali
Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Am Coll Cardiol 52:1141-7. 2008..We sought to assess whether statin-mediated reductions in low-density lipoprotein cholesterol (LDL-C) are associated with an increased risk of cancer... - 17-beta-estradiol increases cardiac remodeling and mortality in mice with myocardial infarctionMartin van Eickels
Medizinsche Poliklinik II, University of Bonn, Bonn, Germany
J Am Coll Cardiol 41:2084-92. 2003..However, estrogen increased post-MI ventricular remodeling and mortality. Further studies will be necessary to elucidate the mechanisms underlying the complex effects of estrogen observed in the present study... - Effect of soy protein from differently processed products on cardiovascular disease risk factors and vascular endothelial function in hypercholesterolemic subjectsNirupa R Matthan
Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
Am J Clin Nutr 85:960-6. 2007..The magnitude of the effect of soy protein on lipoprotein concentrations is variable. This discordance is likely attributable to the various forms of soy protein used and to unrecognized shifts in dietary fatty acid, cholesterol, and fiber... - Tendon rupture associated with simvastatin/ezetimibe therapyRaja C Pullatt
Department of Internal Medicine, University of Connecticut, Farmington, Connecticut, USA
Am J Cardiol 100:152-3. 2007..Statins are known to inhibit MMPs. It was hypothesized that statins may increase the risk of tendon rupture by altering MMP activity. In conclusion, statins may increase the risk of tendon rupture by altering MMP activity... - Present-day uses of niacin: effects on lipid and non-lipid parametersSanjukta Sanyal
Tufts New England Medical Center, Department of Medicine, Division of Cardiology, Boston, Massachusetts 02111, USA
Expert Opin Pharmacother 8:1711-7. 2007..Niacin has the promise of being a powerful pharmacologic agent in the fight against atherosclerotic disease, although additional clinical studies are required to examine this further... - Do the cardiovascular disease risks and benefits of oral versus transdermal estrogen therapy differ between perimenopausal and postmenopausal women?Thomas B Clarkson
Menopause 14:963-7. 2007 - Prevalence of low high-density lipoprotein cholesterol in patients with documented coronary heart disease or risk equivalent and controlled low-density lipoprotein cholesterolAlawi A Alsheikh Ali
Division of Cardiology and Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
Am J Cardiol 100:1499-501. 2007..In conclusion, in high-risk patients with CHD or CHD risk equivalents, low HDL cholesterol levels remain prevalent despite statin treatment and the achievement of aggressive LDL cholesterol goals... - Statins and interstitial lung disease: a systematic review of the literature and of food and drug administration adverse event reportsAntonio B Fernandez
Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA
Chest 134:824-30. 2008..To systematically review all published case reports and the US Food and Drug Administration adverse event reporting (FDA-AER) database to examine the relationship between statins and interstitial lung disease (ILD)... - Effects of estrogen on cardiac electrophysiology in female miceSamir Saba
Molecular Cardiology Research Institute, New England Cardiac Arrhythmia Center, Tufts University-New England Medical Center, Boston, Massachusetts 02111, USA
J Cardiovasc Electrophysiol 13:276-80. 2002..Taken together, these data suggest that hormonal status affects aspects of cardiac EP function. Future application of this mouse model will be helpful in determining the molecular pathways that mediate hormonal differences in cardiac EP...
Research Grants
- Vascular Surgery - Estrogen and the Injury ResponseRichard H Karas; Fiscal Year: 2010....
- VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYSRichard H Karas; Fiscal Year: 2010..These studies have important implications for furthering our understanding of the effects of estrogen on the vascular system and for developing novel therapeutic agents that act via these signaling pathways. ..
- Estrogen and Mechanisms of Cardiomyocyte ProtectionRichard Karas; Fiscal Year: 2009....
- VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYSRichard Karas; Fiscal Year: 2009..These studies have important implications for furthering our understanding of the effects of estrogen on the vascular system and for developing novel therapeutic agents that act via these signaling pathways. ..
- VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYSRichard Karas; Fiscal Year: 2006..These findings may have important implications for post-menopausal women, and for men whose circulating levels of estrogen are low. ..
- VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYSRichard Karas; Fiscal Year: 2002....
- VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYSRichard Karas; Fiscal Year: 2009..Project Description Page 6 ..