Richard Karas

Summary

Affiliation: Tufts Medical Center
Country: USA

Publications

  1. pmc Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3
    Johnthan Gordon
    Department of Biochemistry and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    BMC Biochem 12:54. 2011
  2. doi request reprint Niacin's role in the statin era
    Erica L Brooks
    Preventive Cardiology Center, Tufts Medical Center, Division of Cardiology, Department of Medicine, 800 Washington Street, Box 80, Boston, MA 02111, USA
    Expert Opin Pharmacother 11:2291-300. 2010
  3. ncbi request reprint Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: the OCEANS study
    Richard H Karas
    Division of Cardiology, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    Am J Cardiovasc Drugs 8:69-81. 2008
  4. doi request reprint Niacin and laropiprant
    S Sanyal
    Division of Cardiology, Department of Medicine, Preventive Cardiology Center, Tufts Medical Center, Boston, MA 02111, USA
    Drugs Today (Barc) 46:371-8. 2010
  5. ncbi request reprint Assessment of peripheral vascular endothelial function in the ambulatory setting
    Jeffrey T Kuvin
    Department of Medicine Division of Cardiology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Vasc Med 12:13-6. 2007
  6. ncbi request reprint Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude
    Jeffrey T Kuvin
    Department of Medicine, Division of Cardiology, Tufts New England Medical Center Hospitals, Tufts University School of Medicine, Boston, MA 02111, USA
    Am Heart J 146:168-74. 2003
  7. ncbi request reprint Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta
    Yan Zhu
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    Science 295:505-8. 2002
  8. ncbi request reprint Effects of extended-release niacin on lipoprotein particle size, distribution, and inflammatory markers in patients with coronary artery disease
    Jeffrey T Kuvin
    The Division of Cardiology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 98:743-5. 2006
  9. doi request reprint Assessment of vascular endothelial function with peripheral arterial tonometry: information at your fingertips?
    Eshan A Patvardhan
    Vascular Function Study Group, Department of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA
    Cardiol Rev 18:20-8. 2010
  10. ncbi request reprint Clinical utility of endothelial function testing: ready for prime time?
    Jeffrey T Kuvin
    Division of Cardiology, Tufts New England Medical Center, 750 Washington St, Box 315, Boston, MA 02111, USA
    Circulation 107:3243-7. 2003

Research Grants

  1. Vascular Surgery - Estrogen and the Injury Response
    Richard H Karas; Fiscal Year: 2010
  2. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard H Karas; Fiscal Year: 2010
  3. Estrogen and Mechanisms of Cardiomyocyte Protection
    Richard Karas; Fiscal Year: 2009
  4. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard Karas; Fiscal Year: 2009
  5. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard Karas; Fiscal Year: 2006
  6. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard Karas; Fiscal Year: 2002
  7. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard Karas; Fiscal Year: 2009

Detail Information

Publications84

  1. pmc Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3
    Johnthan Gordon
    Department of Biochemistry and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    BMC Biochem 12:54. 2011
    ..Little is known about the molecular architecture of the striatin complex and the regulation of these sterile 20-like kinases...
  2. doi request reprint Niacin's role in the statin era
    Erica L Brooks
    Preventive Cardiology Center, Tufts Medical Center, Division of Cardiology, Department of Medicine, 800 Washington Street, Box 80, Boston, MA 02111, USA
    Expert Opin Pharmacother 11:2291-300. 2010
    ..Niacin is the most effective agent available at present to increase HDL-C...
  3. ncbi request reprint Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: the OCEANS study
    Richard H Karas
    Division of Cardiology, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    Am J Cardiovasc Drugs 8:69-81. 2008
    ..This fact has focused increased attention on treating abnormalities of non-high-density lipoprotein-cholesterol (non-HDL-C), HDL-C, and triglycerides in national guidelines and has intensified interest in combination therapy...
  4. doi request reprint Niacin and laropiprant
    S Sanyal
    Division of Cardiology, Department of Medicine, Preventive Cardiology Center, Tufts Medical Center, Boston, MA 02111, USA
    Drugs Today (Barc) 46:371-8. 2010
    ..This paper reviews the data suggesting the importance of raising HDL with niacin, describes the pharmacology of the drug, and examines the potential beneficial effects of combining niacin with laropiprant...
  5. ncbi request reprint Assessment of peripheral vascular endothelial function in the ambulatory setting
    Jeffrey T Kuvin
    Department of Medicine Division of Cardiology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Vasc Med 12:13-6. 2007
    ..In conclusion, these data suggest that peripheral vascular endothelial function testing is feasible in ambulatory patients, and this is an important next step in bringing this technology to clinical applicability...
  6. ncbi request reprint Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude
    Jeffrey T Kuvin
    Department of Medicine, Division of Cardiology, Tufts New England Medical Center Hospitals, Tufts University School of Medicine, Boston, MA 02111, USA
    Am Heart J 146:168-74. 2003
    ..We evaluated the relationship between changes in PWA of the finger and peripheral endothelial function...
  7. ncbi request reprint Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta
    Yan Zhu
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    Science 295:505-8. 2002
    ..Furthermore, ERbeta-deficient mice develop sustained systolic and diastolic hypertension as they age. These data support an essential role for ERbeta in the regulation of vascular function and blood pressure...
  8. ncbi request reprint Effects of extended-release niacin on lipoprotein particle size, distribution, and inflammatory markers in patients with coronary artery disease
    Jeffrey T Kuvin
    The Division of Cardiology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 98:743-5. 2006
    ..The effect of altering lipoprotein particle distribution and inflammatory markers on surrogate markers of atherosclerosis and clinical cardiovascular events in this population remains unclear...
  9. doi request reprint Assessment of vascular endothelial function with peripheral arterial tonometry: information at your fingertips?
    Eshan A Patvardhan
    Vascular Function Study Group, Department of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA
    Cardiol Rev 18:20-8. 2010
    ..This review highlights techniques for assessing endothelial function, focusing on a novel method of determining peripheral vascular reactivity via arterial tonometry...
  10. ncbi request reprint Clinical utility of endothelial function testing: ready for prime time?
    Jeffrey T Kuvin
    Division of Cardiology, Tufts New England Medical Center, 750 Washington St, Box 315, Boston, MA 02111, USA
    Circulation 107:3243-7. 2003
  11. doi request reprint Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation
    Cameron Donaldson
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    Circ Res 104:265-75, 11p following 275. 2009
    ..These data support that E2 reduces pressure overload induced hypertrophy by an ER-dependent mechanism that increases CnA degradation, unveiling a novel mechanism by which E2 and ERs regulate pathological LV and cardiomyocyte growth...
  12. doi request reprint Modestly overweight women have vascular endothelial dysfunction
    Ayan R Patel
    Division of Cardiology, Tufts Medical Center, Boston, Massachusetts, USA
    Clin Cardiol 32:269-73. 2009
    ....
  13. ncbi request reprint Modulator recognition factor 1, an AT-rich interaction domain family member, is a novel corepressor for estrogen receptor alpha
    Serban P Georgescu
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Endocrinol 19:2491-501. 2005
    ..These data identify MRF1 as a repressor of ERalpha-mediated transcriptional activation and support a role for MRF1 in regulating ER-dependent gene expression in cardiovascular and other cells...
  14. ncbi request reprint Safety of lovastatin/extended release niacin compared with lovastatin alone, atorvastatin alone, pravastatin alone, and simvastatin alone (from the United States Food and Drug Administration adverse event reporting system)
    Alawi A Alsheikh-Ali
    Molecular Cardiology Research Institute and Division of Cardiology, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 99:379-81. 2007
    ....
  15. ncbi request reprint MAP kinase mediates growth factor-induced nuclear translocation of estrogen receptor alpha
    Qing Lu
    Molecular Cardiology Research Institute, Department of Medicine, and Division of Cardiology, New England Medical Center Hospitals, Tufts University School of Medicine, 750 Washington Street, P O Box 80, 02111, Boston, MA, USA
    FEBS Lett 516:1-8. 2002
    ....
  16. ncbi request reprint Evaluation of peripheral vascular endothelial function with a portable ultrasound device
    Alawi A Alsheikh-Ali
    Division of Cardiology, Department of Medicine, Tufts New England Medical Center Boston, Massachusetts 02111, USA
    Echocardiography 23:623-6. 2006
    ..These findings support the feasibility of noninvasive evaluation of peripheral endothelial function in the ambulatory setting...
  17. pmc Pulse wave amplitude is associated with brachial artery diameter: implications for gender differences in microvascular function
    Kevin S Heffernan
    Vascular Function Study Group, Department of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA
    Vasc Med 15:39-45. 2010
    ..In conclusion, PWA-RHI obtained from PAT is associated with BAD. Studies examining gender differences in microvascular endothelial function with PAT may need to correct for BAD as a potential confounder...
  18. pmc Peripheral arterial tonometry for risk stratification in men with coronary artery disease
    Kevin S Heffernan
    The Vascular Function Study Group Division of Cardiology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Clin Cardiol 33:94-8. 2010
    ..Identification of a simple, noninvasive tool that allows for detection of high-risk CAD patients and can be applied in large populations and clinical settings would prove valuable...
  19. pmc Rapid progress for non-nuclear estrogen receptor signaling
    Michael E Mendelsohn
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    J Clin Invest 120:2277-9. 2010
    ....
  20. ncbi request reprint Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Hypertens 18:1388-95. 2005
    ..Given sex-based differences in cardiac structure and remodeling, we hypothesized that variation in estrogen pathway genes might be associated with alteration of LV structure...
  21. doi request reprint Elevated soluble fms-like tyrosine kinase-1 levels in acute coronary occlusion
    Navin K Kapur
    Molecular Cardiology Research Institute, Division of Cardiology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 31:443-50. 2011
    ..Early recognition of an acute coronary occlusion (ACO) improves clinical outcomes. Soluble fms-like tyrosine kinase-1 (sFLT1) is an endothelium-derived protein induced by hypoxia. We tested whether sFLT1 levels are elevated in ACO...
  22. pmc Usefulness of soluble endoglin as a noninvasive measure of left ventricular filling pressure in heart failure
    Navin K Kapur
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 106:1770-6. 2010
    ..sEng levels also decreased in association with a reduced cardiac filling pressure after diuresis. These findings have identified circulating sEng as a sensitive measure of elevated left heart filling pressures...
  23. pmc Relation of pulse pressure to blood pressure response to exercise in patients with hypertrophic cardiomyopathy
    Kevin S Heffernan
    Hypertrophic Cardiomyopathy Center, Division of Cardiology, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 107:600-3. 2011
    ..24 to 18.2, p <0.05). In conclusion, elevations in PP at rest might identify patients with HC at a greater risk of having an ABPR during exercise...
  24. pmc Elevated augmentation index derived from peripheral arterial tonometry is associated with abnormal ventricular-vascular coupling
    Kevin S Heffernan
    The Vascular Function Study Group, Division of Cardiology, Tufts Medical Center, Molecular Cardiology Research Institute, Boston, MA 02111, USA
    Clin Physiol Funct Imaging 30:313-7. 2010
    ..Little is known regarding the physiologic correlates of AIx derived from PAT. In this study, we investigated the relation of PAT-AIx with measures of ventricular-vascular coupling...
  25. ncbi request reprint Risk of adverse events with concomitant use of atorvastatin or simvastatin and glucose-lowering drugs (thiazolidinediones, metformin, sulfonylurea, insulin, and acarbose)
    Alawi A Alsheikh-Ali
    Department of Medicine, Division of Cardiology, Preventive Cardiology Center, Boston, Massachusetts 02111, USA
    Am J Cardiol 89:1308-10. 2002
  26. ncbi request reprint The relationship of statins to rhabdomyolysis, malignancy, and hepatic toxicity: evidence from clinical trials
    Alawi A Alsheikh-Ali
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Curr Atheroscler Rep 11:100-4. 2009
    ....
  27. pmc Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita mice
    Ho Jin Park
    Tufts Medical Center, Molecular Cardiology Research Institute, 750 Washington St, Box 8486, Boston, MA 02111, USA
    Circ Res 105:287-94. 2009
    ..Sterol regulatory element binding protein-1 (SREBP-1) is a lipid-sensitive transcription factor...
  28. ncbi request reprint Regulation of estrogen receptor alpha-mediated transcription by a direct interaction with protein phosphatase 2A
    Qing Lu
    Department of Medicine and Molecular Cardiology Research Institute, New England Medical Center Hospitals, Inc, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 278:4639-45. 2003
    ....
  29. ncbi request reprint Peripheral vascular endothelial function correlates with exercise capacity in cardiac transplant recipients
    Ayan R Patel
    Division of Cardiology Department of Medicine, Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Cardiol 91:897-9. 2003
  30. pmc Endothelium-dependent vasodilation is associated with exercise capacity in smokers and non-smokers
    Kevin S Heffernan
    Vascular Function Study Group, Tufts Medical Center, Boston, MA 02111, USA
    Vasc Med 15:119-25. 2010
    ..Future research is needed to examine if improving endothelial function will lead to concomitant increases in exercise capacity in chronic smokers...
  31. pmc Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels
    Inga Peter
    Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    J Clin Endocrinol Metab 93:2779-85. 2008
    ..To explore potential mechanisms by which these gene variants may contribute to cardiovascular disease, we tested the hypothesis that the polymorphisms were associated with endogenous steroid hormone levels...
  32. pmc Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP
    Ho Jin Park
    Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Clin Invest 118:259-71. 2008
    ..These results demonstrate a relationship between lipid metabolism and parasympathetic response that may play a role in arrhythmogenesis...
  33. ncbi request reprint High-density lipoprotein cholesterol and coronary heart disease
    Christine E Young
    Department of Medicine Division of Cardiology, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Cardiol Rev 12:107-19. 2004
    ..This review highlights the role of HDL in coronary heart disease, from basic mechanisms of action to recent clinical trial results...
  34. doi request reprint Effect of atenolol vs metoprolol succinate on vascular function in patients with hypertension
    Kevin S Heffernan
    Vascular Function Study Group, Department of Medicine, Division of Cardiology, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    Clin Cardiol 34:39-44. 2011
    ..We evaluated the effect of atenolol vs metoprolol succinate on vascular function in patients with essential hypertension...
  35. ncbi request reprint Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials
    Alawi A Alsheikh-Ali
    Molecular Cardiology Research Institute and Division of Cardiology, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 50:409-18. 2007
    ..We sought to assess the relationship between the magnitude of low-density lipoprotein cholesterol (LDL-C) lowering and rates of elevated liver enzymes, rhabdomyolysis, and cancer...
  36. ncbi request reprint Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha gene
    Inga Peter
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA 02111, USA
    Hypertension 49:1000-6. 2007
    ..Understanding the mechanisms predisposing to unfavorable LV remodeling of the heart with advancing age may aid in the discovery of new therapeutic targets for the prevention of heart failure...
  37. ncbi request reprint Estrogen receptors alpha and beta mediate distinct pathways of vascular gene expression, including genes involved in mitochondrial electron transport and generation of reactive oxygen species
    Raegan O'Lone
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Mol Endocrinol 21:1281-96. 2007
    ..Overall, these findings provide a foundation for understanding the molecular basis for estrogen effects on vasculature gene expression...
  38. doi request reprint The safety of niacin in the US Food and Drug Administration adverse event reporting database
    Alawi A Alsheikh-Ali
    Institute for Clinical Research and Health Policy Studies and Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Cardiol 101:9B-13B. 2008
    ..These analyses should encourage the use of niacin-ER in patients at high risk for cardiovascular disease, as recommended by current national guidelines for cardiovascular prevention...
  39. doi request reprint 17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload
    Richard D Patten
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    J Card Fail 14:245-53. 2008
    ..However, E2 decreases hypertrophy in pressure overload models. We hypothesized that the effect of estrogen on cardiac hypertrophy was dependent on the type of hypertrophic stimulus...
  40. doi request reprint Baseline and on-treatment high-density lipoprotein cholesterol and the risk of cancer in randomized controlled trials of lipid-altering therapy
    Haseeb Jafri
    Molecular Cardiology Research Institute, Department of Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 55:2846-54. 2010
    ..We sought to examine the relationship between high-density lipoprotein cholesterol (HDL-C) levels and the risk of the development of cancer in large randomized controlled trials (RCTs) of lipid-altering interventions...
  41. pmc Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha
    Qing Lu
    Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 101:17126-31. 2004
    ..Furthermore, by demonstrating independent regulation of nongenomic vs. genomic ER-dependent signaling, these findings provide conceptual support for the potential development of "pathway-specific" selective ER modulators...
  42. ncbi request reprint Effects of statins on nonlipid serum markers associated with cardiovascular disease: a systematic review
    Ethan M Balk
    Tufts University School of Medicine and Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 139:670-82. 2003
    ..Statins reduce cardiovascular events to a greater extent than can be explained by their effect on lipids. Several studies have attempted to elucidate mechanisms by which statins reduce cardiovascular risk...
  43. ncbi request reprint The effects of LDL reduction and HDL augmentation on physiologic and inflammatory markers
    Jeffrey T Kuvin
    Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Curr Opin Cardiol 18:295-300. 2003
    ..New therapeutic strategies are being designed to inhibit specific aspects of the inflammatory system that contribute to the initiation and progression of atherosclerosis...
  44. ncbi request reprint A novel mechanism for the beneficial vascular effects of high-density lipoprotein cholesterol: enhanced vasorelaxation and increased endothelial nitric oxide synthase expression
    Jeffrey T Kuvin
    Department of Medicine, New England Medical Center Hospitals, Inc, Tufts University School of Medicine, Boston, Mass, USA
    Am Heart J 144:165-72. 2002
    ..The purpose of this study was to examine the effect of increased HDL levels on endothelium-dependent vasodilation...
  45. ncbi request reprint Relation between high-density lipoprotein cholesterol and peripheral vasomotor function
    Jeffrey T Kuvin
    Department of Medicine Division of Cardiology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Cardiol 92:275-9. 2003
    ..These data suggest that impaired endothelial function associated with low HDL cholesterol may be an additional, previously unrecognized mechanism contributing to the increased risk of atherosclerosis in these patients...
  46. ncbi request reprint Molecular and cellular basis of cardiovascular gender differences
    Michael E Mendelsohn
    Molecular Cardiology Research Institute, Department of Medicine, and Division of Cardiology, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, MA 02111, USA
    Science 308:1583-7. 2005
    ....
  47. ncbi request reprint Extent to which accepted serum lipid goals are achieved in a contemporary general medical population with coronary heart disease risk equivalents
    Alawi A Alsheikh-Ali
    Division of Cardiology and Molecular Cardiology Research Institute, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 98:1231-3. 2006
    ..5% were taking fibrates and 8.2% niacin. In conclusion, the present analysis highlights the dramatic need to further improve preventive measures in a substantial proportion of high-risk patients with CHD risk equivalents...
  48. ncbi request reprint Peripheral vascular endothelial function correlates with exercise capacity in women
    Ayan R Patel
    Division of Cardiology, Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
    Clin Cardiol 28:433-6. 2005
    ..These observations raise the possibility that the relationship between endothelial function and exercise capacity in women may differ from that in men...
  49. ncbi request reprint Estrogen replacement and cardiomyocyte protection
    Richard D Patten
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    Trends Cardiovasc Med 16:69-75. 2006
    ..Further work is necessary to more completely understand the complex effects of sex hormones on cardiomyocyte biology...
  50. doi request reprint Differential effects of statins (pravastatin or simvastatin) on ventricular ectopic complexes: Galpha(i2), a possible molecular marker for ventricular irritability
    C Michael Welzig
    Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Am J Cardiol 105:1112-7. 2010
    ....
  51. ncbi request reprint Statin-associated myopathy
    Paul D Thompson
    Preventive Cardiology and Cardiovascular Research, Division of Cardiology, Hartford Hospital, Hartford, Conn 06102, USA
    JAMA 289:1681-90. 2003
    ..How statins injure skeletal muscle is not clear, although recent evidence suggests that statins reduce the production of small regulatory proteins that are important for myocyte maintenance...
  52. ncbi request reprint Adverse events with concomitant use of simvastatin or atorvastatin and thiazolidinediones
    Alawi A Alsheikh-Ali
    Department of Medicine, Division of Cardiology, Preventive Cardiology Center, Tufts New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
    Am J Cardiol 93:1417-8, A9. 2004
    ..1 times more likely to list rosiglitazone or pioglitazone as a concomitant medication compared with simvastatin-associated adverse event reports...
  53. ncbi request reprint Comparison of the frequency of adverse events in patients treated with atorvastatin or simvastatin
    Heather M Abourjaily
    Department of Pharmacy, Tufts New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
    Am J Cardiol 91:999-1002, A7. 2003
  54. ncbi request reprint Vascular endothelial dysfunction is associated with reversible myocardial perfusion defects in the absence of obstructive coronary artery disease
    Prem Soman
    Division of Cardiology, Tufts New England Medical Center, Boston, Mass, USA
    J Nucl Cardiol 13:756-60. 2006
    ..Recent evidence suggests that coronary endothelial dysfunction might play a role in the pathogenesis of these defects...
  55. pmc Peripheral vascular endothelial function in patients with hypertrophic cardiomyopathy
    Kevin S Heffernan
    The Vascular Function Study Group, The Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 105:112-5. 2010
    ..Patients with HC have impaired peripheral conduit vessel endothelial function, and the magnitude of impairment is similar to that seen in older patients with advanced CAD...
  56. ncbi request reprint Comparison of flow-mediated dilatation of the brachial artery in coronary patients with low-density lipoprotein cholesterol levels <80 mg/dl versus patients with levels 80 to 100 mg/dl
    Jeffrey T Kuvin
    Division of Cardiology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Cardiol 95:93-5. 2005
    ..These data support recent reports that decreasing levels of LDL cholesterol below those currently recommended provides additional benefits and suggest that this benefit may be due in part to increased endothelial function...
  57. ncbi request reprint Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury
    Gary Pare
    Molecular Cardiology Research Institute, New England Medical Center, Boston, Massachusetts, USA
    Circ Res 90:1087-92. 2002
    ..These data demonstrate that estrogen receptor-alpha mediates the protective effects of estrogen on the response to vascular injury...
  58. ncbi request reprint Gender-based differences in brachial artery flow-mediated vasodilation as an indicator of significant coronary artery disease
    Ayan R Patel
    The Division of Cardiology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 96:1223-6. 2005
    ..In studies using FMD to evaluate cardiovascular risk, different standards should be applied for women and men...
  59. ncbi request reprint Adverse events with concomitant amiodarone and statin therapy
    Alawi A Alsheikh-Ali
    Department of Medicine, Division of Cardiology, Preventive Cardiology Center, Tufts New England Medical Center, Boston, MA 02111, USA
    Prev Cardiol 8:95-7. 2005
    ..Use of a statin not metabolized through the cytochrome P450-3A4 system may be appropriate in this setting...
  60. ncbi request reprint Statin use is associated with enhanced collateralization of severely diseased coronary arteries
    Isaac Pourati
    Preventive Cardiology Center, Division of Cardiology, and Department of Medicine, New England Medical Center Hospitals, Boston, Mass, USA
    Am Heart J 146:876-81. 2003
    ..We hypothesized that statin therapy is associated with increased coronary collateral formation in patients with severe coronary artery disease...
  61. pmc Renal actions of RGS2 control blood pressure
    Susan B Gurley
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA
    J Am Soc Nephrol 21:1847-51. 2010
    ..These data support a critical role for the renal epithelium and/or vasculature as the final determinants of the intra-arterial pressure in hypertension...
  62. ncbi request reprint Hormone replacement therapy and the cardiovascular system lessons learned and unanswered questions
    Pamela Ouyang
    Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Coll Cardiol 47:1741-53. 2006
    ..This review outlines the lessons learned from the basic science, animal, observational, and randomized trials, and then summarizes yet-unanswered questions of hormone therapy and cardiovascular risk...
  63. ncbi request reprint High-density lipoprotein cholesterol-raising strategies
    Jeffrey T Kuvin
    Division of Cardiology, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine Boston, Massachusettes 0211, USA
    J Cardiovasc Pharmacol 47:196-204. 2006
    ..Recent findings regarding the role of HDL-C in cholesterol metabolism offer new strategies designed to target atherosclerosis. This review highlights the utility of existing HDL-C-raising strategies and examines new potential therapies...
  64. ncbi request reprint Relative safety of gemfibrozil and fenofibrate in the absence of concomitant cerivastatin use
    Noa Holoshitz
    Molecular Cardiology Research Institute and Division of Cardiology, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 101:95-7. 2008
    ..Rates of all AERs and serious AERs were higher with fenofibrate, but well within the range observed with commonly used lipid-altering medications...
  65. ncbi request reprint Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Hypertens 23:2193-200. 2005
    ..To examine the association between variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in men and women...
  66. ncbi request reprint Association between estrogen receptor alpha gene variation and cardiovascular disease
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Mass 02139, USA
    JAMA 290:2263-70. 2003
    ..Relatively little is known, however, about the impact of genetic variation in estrogen receptor alpha (ESR1) on CVD risk...
  67. doi request reprint Comparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs simvastatin monotherapy in patients with increased non-HDL cholesterol (from the SEACOAST I study)
    Christie M Ballantyne
    Baylor College of Medicine and Methodist DeBakey Heart and Vascular Center, Houston, Texas, USA
    Am J Cardiol 101:1428-36. 2008
    ..In conclusion, this study showed that NER/S provided additional clinically relevant improvements in multiple lipid parameters and was safe and well tolerated...
  68. ncbi request reprint Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study
    Serkalem Demissie
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, TE425 Boston, MA 02118, USA
    Atherosclerosis 185:210-8. 2006
    ..30T-c.454-397T-c.454-351A haplotype (frequency, 46%), where L and S are long and short TA repeats. Our results suggest that common ESR1 polymorphisms have a significant effect on lipoprotein metabolism in women...
  69. pmc p38 mitogen-activated protein kinase activates eNOS in endothelial cells by an estrogen receptor alpha-dependent pathway in response to black tea polyphenols
    Elad Anter
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
    Circ Res 96:1072-8. 2005
    ..These findings suggest p38 MAP kinase-mediated eNOS activation requires ERalpha and these data uncover a new mechanism of ERalpha activation that has broad implications for NO bioactivity and endothelial cell phenotype...
  70. ncbi request reprint Is the WHI relevant to HRT started in the perimenopause?
    S Mitchell Harman
    Kronos Longevity Research Institute, Phoenix, AZ, USA
    Endocrine 24:195-202. 2004
    ..Furthermore, animal and clinical evidence supports the use of lower doses of estrogen than were employed in the WHI in older/longer postmenopausal women...
  71. ncbi request reprint Effects of statins on vascular structure and function: a systematic review
    Ethan M Balk
    Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies
    Am J Med 117:775-90. 2004
    ..We conducted a systematic review of how statins affect vascular structure and function, differences among statins, and correlations between the effects of statins on vascular outcomes and either lipid levels or cardiovascular outcomes...
  72. ncbi request reprint Risk of adverse events with fibrates
    Alawi A Alsheikh-Ali
    Molecular Cardiology Research Institute, Department of Medicine, Division of Cardiology, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Cardiol 94:935-8. 2004
    ..This difference was especially noticeable in patients taking the combination of gemfibrozil and a statin, particularly cerivastatin...
  73. ncbi request reprint 17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling
    Richard D Patten
    Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center, 750 Washington St, Boston MA 02111, USA
    Circ Res 95:692-9. 2004
    ....
  74. ncbi request reprint Current controversies regarding the cardiovascular effects of hormone therapy
    Richard H Karas
    Department of Medicine, Division of Cardiology, Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Clin Obstet Gynecol 47:489-99. 2004
  75. ncbi request reprint High-density lipoprotein cholesterol in the cardiovascular equation: does the "good" still count?
    Alawi A Alsheikh-Ali
    Molecular Cardiology Research Institute, Division of Cardiology, Tufts New England Medical Center, Tufts University School of Medicine, 750 Washington Street, Box 80, Boston, MA 02111, USA
    Atherosclerosis 180:217-23. 2005
    ....
  76. doi request reprint Statins, low-density lipoprotein cholesterol, and risk of cancer
    Alawi A Alsheikh-Ali
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 52:1141-7. 2008
    ..We sought to assess whether statin-mediated reductions in low-density lipoprotein cholesterol (LDL-C) are associated with an increased risk of cancer...
  77. ncbi request reprint 17-beta-estradiol increases cardiac remodeling and mortality in mice with myocardial infarction
    Martin van Eickels
    Medizinsche Poliklinik II, University of Bonn, Bonn, Germany
    J Am Coll Cardiol 41:2084-92. 2003
    ..This study was designed to examine the effects of estrogen replacement on infarct size, ventricular remodeling, and mortality after myocardial infarction (MI) in mice...
  78. ncbi request reprint Effect of soy protein from differently processed products on cardiovascular disease risk factors and vascular endothelial function in hypercholesterolemic subjects
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Am J Clin Nutr 85:960-6. 2007
    ..The magnitude of the effect of soy protein on lipoprotein concentrations is variable. This discordance is likely attributable to the various forms of soy protein used and to unrecognized shifts in dietary fatty acid, cholesterol, and fiber...
  79. ncbi request reprint Tendon rupture associated with simvastatin/ezetimibe therapy
    Raja C Pullatt
    Department of Internal Medicine, University of Connecticut, Farmington, Connecticut, USA
    Am J Cardiol 100:152-3. 2007
    ..Statins are known to inhibit MMPs. It was hypothesized that statins may increase the risk of tendon rupture by altering MMP activity. In conclusion, statins may increase the risk of tendon rupture by altering MMP activity...
  80. ncbi request reprint Present-day uses of niacin: effects on lipid and non-lipid parameters
    Sanjukta Sanyal
    Tufts New England Medical Center, Department of Medicine, Division of Cardiology, Boston, Massachusetts 02111, USA
    Expert Opin Pharmacother 8:1711-7. 2007
    ..Niacin has the promise of being a powerful pharmacologic agent in the fight against atherosclerotic disease, although additional clinical studies are required to examine this further...
  81. ncbi request reprint Do the cardiovascular disease risks and benefits of oral versus transdermal estrogen therapy differ between perimenopausal and postmenopausal women?
    Thomas B Clarkson
    Menopause 14:963-7. 2007
  82. ncbi request reprint Prevalence of low high-density lipoprotein cholesterol in patients with documented coronary heart disease or risk equivalent and controlled low-density lipoprotein cholesterol
    Alawi A Alsheikh-Ali
    Division of Cardiology and Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 100:1499-501. 2007
    ..In conclusion, in high-risk patients with CHD or CHD risk equivalents, low HDL cholesterol levels remain prevalent despite statin treatment and the achievement of aggressive LDL cholesterol goals...
  83. doi request reprint Statins and interstitial lung disease: a systematic review of the literature and of food and drug administration adverse event reports
    Antonio B Fernandez
    Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA
    Chest 134:824-30. 2008
    ..To systematically review all published case reports and the US Food and Drug Administration adverse event reporting (FDA-AER) database to examine the relationship between statins and interstitial lung disease (ILD)...
  84. ncbi request reprint Effects of estrogen on cardiac electrophysiology in female mice
    Samir Saba
    Molecular Cardiology Research Institute, New England Cardiac Arrhythmia Center, Tufts University New England Medical Center, Boston, Massachusetts 02111, USA
    J Cardiovasc Electrophysiol 13:276-80. 2002
    ..We examined the effect of hormonal status on the electrophysiologic (EP) properties of the mouse heart in an in vivo, closed chest model...

Research Grants15

  1. Vascular Surgery - Estrogen and the Injury Response
    Richard H Karas; Fiscal Year: 2010
    ....
  2. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard H Karas; Fiscal Year: 2010
    ..These studies have important implications for furthering our understanding of the effects of estrogen on the vascular system and for developing novel therapeutic agents that act via these signaling pathways. ..
  3. Estrogen and Mechanisms of Cardiomyocyte Protection
    Richard Karas; Fiscal Year: 2009
    ....
  4. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard Karas; Fiscal Year: 2009
    ..These studies have important implications for furthering our understanding of the effects of estrogen on the vascular system and for developing novel therapeutic agents that act via these signaling pathways. ..
  5. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard Karas; Fiscal Year: 2006
    ..These findings may have important implications for post-menopausal women, and for men whose circulating levels of estrogen are low. ..
  6. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard Karas; Fiscal Year: 2002
    ....
  7. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard Karas; Fiscal Year: 2009
    ..Project Description Page 6 ..