J Joseph

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Muscarinic receptor subtype determines vulnerability to oxidative stress in COS-7 cells
    J A Joseph
    USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 32:153-61. 2002
  2. ncbi request reprint Oxidative stress protection and vulnerability in aging: putative nutritional implications for intervention
    J A Joseph
    USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Mech Ageing Dev 116:141-53. 2000
  3. ncbi request reprint Copernicus revisited: amyloid beta in Alzheimer's disease
    J Joseph
    USDA HNRC at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    Neurobiol Aging 22:131-46. 2001
  4. ncbi request reprint Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats
    P C Bickford
    Department of Pharmacology, Boston, MA, USA
    Brain Res 866:211-7. 2000
  5. ncbi request reprint Effects of fruits and vegetables on levels of vitamins E and C in the brain and their association with cognitive performance
    A Martin
    USDA Neuroscience Laboratory, Jean Mayer USDA Human Nutrition, Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Health Aging 6:392-404. 2002
  6. ncbi request reprint Influence of photoperiod, laboratory caging and aging on plasma lipid response to an atherogenic diet among F1B hamsters
    D Smith
    Comparative Biology and Medicine, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Int J Neurosci 106:185-94. 2001
  7. ncbi request reprint Neurite outgrowth in PC12 cells. Distinguishing the roles of ubiquitylation and ubiquitin-dependent proteolysis
    M Obin
    Laboratory for Nutrition and Vision Research, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 274:11789-95. 1999
  8. ncbi request reprint The effects of proton exposure on neurochemistry and behavior
    B Shukitt-Hale
    USDA ARS, Human Nutrition Research Center of Aging at Tufts Universty, Boston, MA 02111, USA
    Adv Space Res 33:1334-9. 2004
  9. ncbi request reprint The effects of heavy particle irradiation on exploration and response to environmental change
    G Casadesus
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Adv Space Res 33:1340-6. 2004
  10. ncbi request reprint Heavy particle irradiation, neurochemistry and behavior: thresholds, dose-response curves and recovery of function
    B M Rabin
    Department of Psychology, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Adv Space Res 33:1330-3. 2004

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Muscarinic receptor subtype determines vulnerability to oxidative stress in COS-7 cells
    J A Joseph
    USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 32:153-61. 2002
    ..Results are discussed in terms of receptor involvement in the regional differences in Vulnerability to oxidative stress with age, and that loss of neuronal function may not inevitably lead to cell death...
  2. ncbi request reprint Oxidative stress protection and vulnerability in aging: putative nutritional implications for intervention
    J A Joseph
    USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Mech Ageing Dev 116:141-53. 2000
    ..Thus, it appears that the beneficial effects of the polyphenolics found in fruits and vegetables in neuronal aging and behavior may be similar to those seen with respect to carcinogenesis and cardiovascular disease...
  3. ncbi request reprint Copernicus revisited: amyloid beta in Alzheimer's disease
    J Joseph
    USDA HNRC at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    Neurobiol Aging 22:131-46. 2001
    ....
  4. ncbi request reprint Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats
    P C Bickford
    Department of Pharmacology, Boston, MA, USA
    Brain Res 866:211-7. 2000
    ..These data are the first to indicate that age-related deficits in motor learning and memory can be reversed with nutritional interventions...
  5. ncbi request reprint Effects of fruits and vegetables on levels of vitamins E and C in the brain and their association with cognitive performance
    A Martin
    USDA Neuroscience Laboratory, Jean Mayer USDA Human Nutrition, Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Health Aging 6:392-404. 2002
    ..This paper will review the scientific literature on the sources, tissue levels and roles of vitamins E and C in cognitive performance and pathologic processes of the central nervous system in the elderly...
  6. ncbi request reprint Influence of photoperiod, laboratory caging and aging on plasma lipid response to an atherogenic diet among F1B hamsters
    D Smith
    Comparative Biology and Medicine, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Int J Neurosci 106:185-94. 2001
    ..005). In conclusion, photoperiod length dramatically affects diet-induced plasma lipid concentrations in young male F1B hamsters, and thus needs be considered in experimental designs of animal-housed lipid research...
  7. ncbi request reprint Neurite outgrowth in PC12 cells. Distinguishing the roles of ubiquitylation and ubiquitin-dependent proteolysis
    M Obin
    Laboratory for Nutrition and Vision Research, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 274:11789-95. 1999
    ....
  8. ncbi request reprint The effects of proton exposure on neurochemistry and behavior
    B Shukitt-Hale
    USDA ARS, Human Nutrition Research Center of Aging at Tufts Universty, Boston, MA 02111, USA
    Adv Space Res 33:1334-9. 2004
    ..Therefore, there is a contrast between the insignificant effects of high dose proton exposure and the dramatic effectiveness of low dose (<0.1 Gy) exposures to 56Fe particles on both neurochemical and behavioral endpoints...
  9. ncbi request reprint The effects of heavy particle irradiation on exploration and response to environmental change
    G Casadesus
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Adv Space Res 33:1340-6. 2004
    ..5 Gy of 56Fe high-energy particle radiation elicited age-like effects in general open field exploratory behavior, but did not elicit age-like effects during the spatial and non-spatial rearrangement tasks...
  10. ncbi request reprint Heavy particle irradiation, neurochemistry and behavior: thresholds, dose-response curves and recovery of function
    B M Rabin
    Department of Psychology, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Adv Space Res 33:1330-3. 2004
    ..The current report reviews the data relevant to the degree to which these characteristics are common to neurochemical and behavioral endpoints that are mediated by the effects of exposure to heavy particles on CNS activity...
  11. ncbi request reprint The effects of antioxidants in the senescent auditory cortex
    C de Rivera
    Department of Speech Language Pathology, University of Toronto, Toronto, Ont, Canada M5G 1V7
    Neurobiol Aging 27:1035-44. 2006
    ..These results suggest that age-related changes in temporal processing speed in A1 may be reversed by dietary supplementation of blueberry phytochemicals...
  12. ncbi request reprint Oxidative stress and inflammation in brain aging: nutritional considerations
    J A Joseph
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Neurochem Res 30:927-35. 2005
    ..Importantly, using muscarinic receptors as examples, we will also try to show that the sensitivity to these insults may be differentially expressed among neurotransmitter receptor subtypes...
  13. ncbi request reprint Blueberry extract alters oxidative stress-mediated signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes
    J A Joseph
    USDA HNRC at Tufts University, Boston, MA 02111, USA
    J Alzheimers Dis 9:35-42. 2006
    ..These findings also suggest that BB may antagonize oxidative stress effects induced by DA in M1-transfected cells by lowering activation of pCREB, and possibly pPKCgamma...
  14. ncbi request reprint Dopamine-induced stress signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes is partially mediated via the i3 loop and antagonized by blueberry extract
    J A Joseph
    USDA HNRCA at Tufts University, Boston, MA 02111, USA
    J Alzheimers Dis 10:423-37. 2006
    ..A similar partial effect of BBs was seen in the M3(M1i3) chimerics which showed increased OSS in response to DA. It appears that antioxidants found in BBs might be targeting additional sites on these chimerics to decrease OSS...
  15. ncbi request reprint Muscarinic receptor subtype determines vulnerability to amyloid beta toxicity in transfected cos-7 cells
    J A Joseph
    USDA Human Nutrition Research Center on Aging at Tufts University Boston, MA 02111, USA
    J Alzheimers Dis 5:197-208. 2003
    ..Results are discussed in terms of differences in MAChR structure that could lead to selective Abeta effects and the possible implications on memory and AbetaPP processing...
  16. ncbi request reprint Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model
    J A Joseph
    USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Neurosci 6:153-62. 2003
    ..Thus, our data indicate for the first time that it may be possible to overcome genetic predispositions to Alzheimer disease through diet...
  17. ncbi request reprint A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects
    K A Youdim
    Department of Neuroscience, United States Department of Agriculture, Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 30:583-94. 2001
    ....
  18. ncbi request reprint Antioxidant and pro-oxidant capacity of catecholamines and related compounds. Effects of hydrogen peroxide on glutathione and sphingomyelinase activity in pheochromocytoma PC12 cells: potential relevance to age-related diseases
    E Sofic
    Phytochemical Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Neural Transm 108:541-57. 2001
    ....
  19. ncbi request reprint Dopamine and Abeta-induced stress signaling and decrements in Ca2+ buffering in primary neonatal hippocampal cells are antagonized by blueberry extract
    J A Joseph
    USDA HNRC at Tufts University, Boston, MA 02111, USA
    J Alzheimers Dis 11:433-46. 2007
    ..Therefore it appears that at least part of the protective effect of BBs may involve alterations in stress signaling...
  20. ncbi request reprint Brain signaling and behavioral responses induced by exposure to (56)Fe-particle radiation
    N A Denisova
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Radiat Res 158:725-34. 2002
    ....
  21. ncbi request reprint Cognitive deficits induced by 56Fe radiation exposure
    B Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Adv Space Res 31:119-26. 2003
    ..These results show that irradiation with high-energy particles produces age-like decrements in cognitive behavior that may impair the ability of astronauts to perform critical tasks during long-term space travel beyond the magnetosphere...
  22. ncbi request reprint Long-term changes in amphetamine-induced reinforcement and aversion in rats following exposure to 56Fe particle
    B M Rabin
    Dept of Physiology, University of Maryland Baltimore County, MD 21250, USA
    Adv Space Res 31:127-33. 2003
    ..The results are interpreted as indicating that exposure to heavy particles can produce long-term changes in behavioral functioning...
  23. ncbi request reprint Effects of exposure to 56Fe particles on the acquisition of a conditioned place preference in rats
    B M Rabin
    Dept.of Psychology, UMBC, Baltimore, MD 21250, USA
    Phys Med 17:196-7. 2001
    ..The results of the experiment indicate that exposure to low doses of heavy particles can disrupt the neural mechanisms that mediate the reinforcement of behavior...
  24. ncbi request reprint Relative effectiveness of different particles and energies in disrupting behavioral performance
    B M Rabin
    Department of Psychology, UMBC, Baltimore, MD 21250, USA
    Radiat Environ Biophys 46:173-7. 2007
    ..This review indicates that the RBE of different particles for neurobehavioral dysfunction cannot be predicted only on the basis of the linear energy transfer of the specific particle...
  25. ncbi request reprint Automated measurement of age-related changes in the locomotor response to environmental novelty and home-cage activity
    G Casadesus
    USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Rm 919, 711 Washington Street, Boston, MA 2111, USA
    Mech Ageing Dev 122:1887-97. 2001
    ..No differences were seen in rearing behavior. These findings provide a more detailed analysis and additional evidence of the activity decreases and rhythmic changes seen in aged F344 rats under uninterrupted testing conditions...