Elizabeth J Johnson

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Potential role of dietary n-3 fatty acids in the prevention of dementia and macular degeneration
    Elizabeth J Johnson
    Carotenoid and Health and Lipid Metabolism Laboratories, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 83:1494S-1498S. 2006
  2. pmc Nutrients for the aging eye
    Helen M Rasmussen
    Educational Studies, Lesley University, Cambridge, MA, USA
    Clin Interv Aging 8:741-8. 2013
  3. doi request reprint A possible role for lutein and zeaxanthin in cognitive function in the elderly
    Elizabeth J Johnson
    Carotenoids and Health Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 96:1161S-5S. 2012
  4. ncbi request reprint The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation
    Elizabeth J Johnson
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Am J Clin Nutr 87:1521-9. 2008
  5. doi request reprint Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women
    Elizabeth J Johnson
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Nutr Neurosci 11:75-83. 2008
  6. doi request reprint Intake of lutein and zeaxanthin differ with age, sex, and ethnicity
    Elizabeth J Johnson
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Am Diet Assoc 110:1357-62. 2010
  7. ncbi request reprint A comparison of carotenoids, retinoids, and tocopherols in the serum and buccal mucosa of chronic cigarette smokers versus nonsmokers
    Helen E Gabriel
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cancer Epidemiol Biomarkers Prev 15:993-9. 2006
  8. doi request reprint Age-related macular degeneration and antioxidant vitamins: recent findings
    Elizabeth J Johnson
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Clin Nutr Metab Care 13:28-33. 2010
  9. ncbi request reprint Nutritional manipulation of primate retinas, III: Effects of lutein or zeaxanthin supplementation on adipose tissue and retina of xanthophyll-free monkeys
    Elizabeth J Johnson
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 46:692-702. 2005
  10. ncbi request reprint Obesity, lutein metabolism, and age-related macular degeneration: a web of connections
    Elizabeth J Johnson
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Nutr Rev 63:9-15. 2005

Detail Information

Publications38

  1. ncbi request reprint Potential role of dietary n-3 fatty acids in the prevention of dementia and macular degeneration
    Elizabeth J Johnson
    Carotenoid and Health and Lipid Metabolism Laboratories, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 83:1494S-1498S. 2006
    ..7 fish servings/wk) is associated with an approximately 50% reduction in dementia risk. At least this amount of DHA is generally found in one commercially available 1-g fish oil capsule given daily...
  2. pmc Nutrients for the aging eye
    Helen M Rasmussen
    Educational Studies, Lesley University, Cambridge, MA, USA
    Clin Interv Aging 8:741-8. 2013
    ..Therefore, it is important to educate this population and to create an awareness of the nutrients and foods of particular interest in the prevention of age-related eye disease. ..
  3. doi request reprint A possible role for lutein and zeaxanthin in cognitive function in the elderly
    Elizabeth J Johnson
    Carotenoids and Health Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 96:1161S-5S. 2012
    ..When all of these observations are taken into consideration, the idea that lutein and zeaxanthin can influence cognitive function in older adults warrants further study...
  4. ncbi request reprint The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation
    Elizabeth J Johnson
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Am J Clin Nutr 87:1521-9. 2008
    ..Lutein and docosahexaenoic acid (DHA) may protect against age-related macular degeneration (AMD). Lutein is a component of macular pigment. DHA is in the retina...
  5. doi request reprint Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women
    Elizabeth J Johnson
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Nutr Neurosci 11:75-83. 2008
    ..Low dietary intake of docosahexaenoic acid (DHA) and/or foods rich in lutein may be associated with increased risk of cognitive decline in the elderly...
  6. doi request reprint Intake of lutein and zeaxanthin differ with age, sex, and ethnicity
    Elizabeth J Johnson
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Am Diet Assoc 110:1357-62. 2010
    ..Our findings suggest that the relative intake of lutein and zeaxanthin may be important to age-related macular degeneration risk. Future studies are needed to assess the individual associations of lutein and zeaxanthin in eye health...
  7. ncbi request reprint A comparison of carotenoids, retinoids, and tocopherols in the serum and buccal mucosa of chronic cigarette smokers versus nonsmokers
    Helen E Gabriel
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cancer Epidemiol Biomarkers Prev 15:993-9. 2006
    ..Such effects may be important because these nutrients, as well as retinoids, are putative chemoprotective agents...
  8. doi request reprint Age-related macular degeneration and antioxidant vitamins: recent findings
    Elizabeth J Johnson
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Clin Nutr Metab Care 13:28-33. 2010
    ....
  9. ncbi request reprint Nutritional manipulation of primate retinas, III: Effects of lutein or zeaxanthin supplementation on adipose tissue and retina of xanthophyll-free monkeys
    Elizabeth J Johnson
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 46:692-702. 2005
    ..In this study the effects of L or Z supplementation on carotenoid levels was examined in serum, adipose tissue, and retina in rhesus monkeys with no previous intake of xanthophylls...
  10. ncbi request reprint Obesity, lutein metabolism, and age-related macular degeneration: a web of connections
    Elizabeth J Johnson
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Nutr Rev 63:9-15. 2005
    ..Therefore, the mechanism by which obesity is related to AMD risk may be through indirect effects on changes in lutein and zeaxanthin status and metabolism...
  11. pmc Serum carotenoid and tocopherol concentrations vary by dietary pattern among African Americans
    Sameera A Talegawkar
    Tufts University, Boston, MA, USA
    J Am Diet Assoc 108:2013-20. 2008
    ..Intakes and biochemical concentrations of carotenoids and tocopherols have been associated with chronic diseases...
  12. pmc Carotenoid intakes, assessed by food-frequency questionnaires (FFQs), are associated with serum carotenoid concentrations in the Jackson Heart Study: validation of the Jackson Heart Study Delta NIRI Adult FFQs
    Sameera A Talegawkar
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Public Health Nutr 11:989-97. 2008
    ....
  13. pmc Macular lutein and zeaxanthin are related to brain lutein and zeaxanthin in primates
    Rohini Vishwanathan
    Carotenoids and Health Lab, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Nutr Neurosci 16:21-9. 2013
    ..Lutein and zeaxanthin also accumulate in brain tissue. The objective of the study was to evaluate the relationship between retinal and brain levels of these xanthophylls in non-human primates...
  14. ncbi request reprint Carotenoid actions and their relation to health and disease
    Norman I Krinsky
    Department of Biochemistry, School of Medicine, Tufts University, 136 Harrison Avenue, Boston, MA 02111 1837, USA
    Mol Aspects Med 26:459-516. 2005
    ..Until the efficacy and safety of taking supplements containing these nutrients can be determined, current dietary recommendations of diets high in fruits and vegetables are advised...
  15. ncbi request reprint Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women
    Xianfeng Zhao
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 83:163-9. 2006
    ..Carotenoids could be a part of a protective strategy to minimize oxidative damage in vulnerable populations, such as the elderly...
  16. pmc Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells
    Qingning Bian
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 53:1298-307. 2012
    ..Similar mechanisms may explain salutary effects of lutein and zeaxanthin in reducing the risk for AMD...
  17. pmc Metabolism of lutein and zeaxanthin in rhesus monkeys: identification of (3R,6'R)- and (3R,6'S)-3'-dehydro-lutein as common metabolites and comparison to humans
    Gesa I Albert
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
    Comp Biochem Physiol B Biochem Mol Biol 151:70-8. 2008
    ..A pathway for their formation from either lutein or zeaxanthin is proposed. These findings were comparable to results obtained with human plasma...
  18. pmc Supplementation with lutein or lutein plus green tea extracts does not change oxidative stress in adequately nourished older adults
    Lei Li
    The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 21:544-9. 2010
    ....
  19. pmc The relationship of macular pigment optical density to serum lutein in retinitis pigmentosa
    Michael A Sandberg
    The Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 51:1086-91. 2010
    ..To determine whether macular pigment optical density (MPOD) is related to serum lutein or serum zeaxanthin in patients with retinitis pigmentosa...
  20. pmc Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A
    Eliot L Berson
    Berman Gund Laboratory for Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Arch Ophthalmol 128:403-11. 2010
    ..To determine whether lutein supplementation will slow visual function decline in patients with retinitis pigmentosa receiving vitamin A...
  21. ncbi request reprint Lutein bioavailability is higher from lutein-enriched eggs than from supplements and spinach in men
    Hae Yun Chung
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 134:1887-93. 2004
    ..The lutein bioavailability from lutein, lutein ester supplements, and spinach did not differ. This finding may have implications for dietary recommendations that may decrease the risk of certain diseases, e.g., ARMD...
  22. pmc The role of phytonutrients in skin health
    Julie A Evans
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Nutrients 2:903-28. 2010
    ..In regard to skin health, phytonutrients of interest include vitamin E, certain flavonoids, and the carotenoids, β-carotene, lycopene and lutein...
  23. doi request reprint Determination of carotenoids in yellow maize, the effects of saponification and food preparations
    Tawanda Muzhingi
    Dorothy J and Gerald R Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Int J Vitam Nutr Res 78:112-20. 2008
    ....
  24. doi request reprint Determination of 9-cis beta-carotene and zeta-carotene in biological samples
    Jian Qin
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 19:612-8. 2008
    ..1+/-0.8 and 1.1+/-0.2 nM, and 15.6+/-1.1 nM and 0.2+/-0.1 nmol/g, respectively. zetaC concentrations in the above samples were 54.2+/-7.2 and 8.3+/-1.8 nM, and 49.0+/-3.9 nM and 0.3+/-0.1 nmol/g, respectively...
  25. pmc Factors associated with serum retinol, alpha-tocopherol, carotenoids, and selenium in Hispanics with problems of HIV, chronic hepatitis C, and drug use
    Janet E Forrester
    Tufts University School of Medicine, Boston, MA, US
    J Public Health Policy 30:285-99. 2009
    ..As the safety of micronutrient supplementation is not established, policy for appropriate HIV clinical care should distinguish between populations with and without hepatitis coinfection...
  26. ncbi request reprint The role of carotenoids in human health
    Elizabeth J Johnson
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Clin Care 5:56-65. 2002
    ..Until the efficacy and safety of taking supplements containing these nutrients can be determined, current dietary recommendations of diets high in fruits and vegetables are advised...
  27. doi request reprint A pilot study of the photoprotective effect of almond phytochemicals in a 3D human skin equivalent
    Julie A Evans-Johnson
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Photochem Photobiol B 126:17-25. 2013
    ..05). In conclusion, we validated the feasibility of using HSE in evaluation of photoprotectants and found that AT and AP, applied to medium or topically, provided some degree of photoprotection against UVA. ..
  28. ncbi request reprint Total alpha-tocopherol intakes are associated with serum alpha-tocopherol concentrations in African American adults
    Sameera A Talegawkar
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 137:2297-303. 2007
    ..Supplement use was associated with higher alpha- but lower gamma-tocopherol concentration in serum. The possible health implications of this difference in relative tocopherol subtypes require further study...
  29. ncbi request reprint Plasma antioxidant capacity in response to diets high in soy or animal protein with or without isoflavones
    Sonia Vega-Lopez
    Cardiovascular Nutrition Laboratory and the Carotenoids and Health Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 81:43-9. 2005
    ..Several clinical trials have suggested that soy intake decreases oxidative stress. Soy isoflavones have antioxidant properties in vitro, but results of supplementation in clinical trials are inconclusive...
  30. doi request reprint Time availability and preference for e-health communication channels for nutrition and physical activity
    Lisa M Quintiliani
    Boston University, Boston, MA 02118, USA
    J Cancer Educ 28:408-11. 2013
    ..05). Our study suggests that time availability may be another important factor to consider when planning cancer prevention programs...
  31. ncbi request reprint Lutein and age-related ocular disorders in the older adult: a review
    Lisa M Renzi
    Vision Science Laboratory, University of Georgia, Athens 30602, USA
    J Nutr Elder 26:139-57. 2007
    ..The mechanism by which these factors are related to risk may be partially due to adverse effects on lutein status...
  32. ncbi request reprint Nutritional manipulation of primate retinas, I: effects of lutein or zeaxanthin supplements on serum and macular pigment in xanthophyll-free rhesus monkeys
    Martha Neuringer
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Portalnd 97006
    Invest Ophthalmol Vis Sci 45:3234-43. 2004
    ..In this study, L or Z was fed to rhesus monkeys reared on xanthophyll-free diets to follow the accumulation of serum carotenoids and MP over time...
  33. ncbi request reprint Predictors of optical density of lutein and zeaxanthin in retinas of older women in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women's Health Initiative
    Julie A Mares
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA
    Am J Clin Nutr 84:1107-22. 2006
    ..Lifestyle, diet, and physical and health predictors of xanthophyll carotenoids in the retina are poorly understood...
  34. pmc Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health Initiative
    Suzen M Moeller
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726 2336, USA
    Arch Ophthalmol 126:354-64. 2008
    ..To evaluate associations between nuclear cataract (determined from slitlamp photographs between May 2001 and January 2004) and lutein and zeaxanthin in the diet and serum in patients between 1994 and 1998 and macula between 2001 and 2004...
  35. ncbi request reprint Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration
    Wei Wang
    Department of Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Am J Clin Nutr 85:762-9. 2007
    ..Low dietary intakes and low plasma concentrations of lutein and zeaxanthin are associated with an increased risk of age-related macular degeneration (AMD). No studies have challenged AMD patients with a diet high in lutein and zeaxanthin...
  36. pmc Macular pigment optical density in the elderly: findings in a large biracial Midsouth population sample
    Alessandro Iannaccone
    Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, 930 Madison Avenue, Memphis, TN 38163, USA
    Invest Ophthalmol Vis Sci 48:1458-65. 2007
    ..5 degrees of eccentricity from the fovea in elderly subjects participating in ARMA, a study of aging and age-related maculopathy (ARM) ancillary to the Health, Aging, and Body Composition (Health ABC) Study...
  37. ncbi request reprint The selective retention of lutein, meso-zeaxanthin and zeaxanthin in the retina of chicks fed a xanthophyll-free diet
    YingMing Wang
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, L465, Oregon Health and Science University, Portland, OR 972391, USA
    Exp Eye Res 84:591-8. 2007
    ..It is clear that these xanthophylls may have an essential role in the cone-rich retina of the chick as evidenced by their selective retention...