Research Topics
Species | Kevin S HeffernanSummaryAffiliation: Tufts Medical Center Country: USA Publications
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Publications
Endothelium-dependent vasodilation is associated with exercise capacity in smokers and non-smokersKevin S Heffernan
Vascular Function Study Group, Tufts Medical Center, Boston, MA 02111, USA
Vasc Med 15:119-25. 2010..Future research is needed to examine if improving endothelial function will lead to concomitant increases in exercise capacity in chronic smokers...
Resistance exercise training reduces central blood pressure and improves microvascular function in African American and white menKevin S Heffernan
Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL, United States
Atherosclerosis 207:220-6. 2009..The purpose of this study was to examine the effect of resistance exercise training (RT) on vascular function and central blood pressure (BP) in young (22 years) African American and white men...- L-arginine as a nutritional prophylaxis against vascular endothelial dysfunction with agingKevin S Heffernan
Division of Cardiology, Department of Medicine, The Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
J Cardiovasc Pharmacol Ther 15:17-23. 2010..Emphasis will be placed on the ability of L-arginine to modulate the vascular inflammatory and systemic hormonal milieu, which in turn may have a positive effect on vascular endothelial function... - Effect of atenolol vs metoprolol succinate on vascular function in patients with hypertensionKevin S Heffernan
Vascular Function Study Group, Department of Medicine, Division of Cardiology, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
Clin Cardiol 34:39-44. 2011..We evaluated the effect of atenolol vs metoprolol succinate on vascular function in patients with essential hypertension... - Relation of pulse pressure to blood pressure response to exercise in patients with hypertrophic cardiomyopathyKevin S Heffernan
Hypertrophic Cardiomyopathy Center, Division of Cardiology, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
Am J Cardiol 107:600-3. 2011..24 to 18.2, p <0.05). In conclusion, elevations in PP at rest might identify patients with HC at a greater risk of having an ABPR during exercise... - Effect of increased preload on the synthesized aortic blood pressure waveformKevin S Heffernan
Tufts Medical Center, Molecular Cardiology Research Institute and the Dept of Medicine, Division of Cardiology, 800 Washington St, Boston, MA 02111, USA
J Appl Physiol 109:484-90. 2010..These data suggest that in a setting of isolated augmented preload with minimal changes in other potential confounders, the morphology of the synthesized aortic BP waveform and AIx may be related to changes in aortic reservoir function... - Elevated augmentation index derived from peripheral arterial tonometry is associated with abnormal ventricular-vascular couplingKevin S Heffernan
The Vascular Function Study Group, Division of Cardiology, Tufts Medical Center, Molecular Cardiology Research Institute, Boston, MA 02111, USA
Clin Physiol Funct Imaging 30:313-7. 2010..Little is known regarding the physiologic correlates of AIx derived from PAT. In this study, we investigated the relation of PAT-AIx with measures of ventricular-vascular coupling... - Pulse wave amplitude is associated with brachial artery diameter: implications for gender differences in microvascular functionKevin S Heffernan
Vascular Function Study Group, Department of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA
Vasc Med 15:39-45. 2010..In conclusion, PWA-RHI obtained from PAT is associated with BAD. Studies examining gender differences in microvascular endothelial function with PAT may need to correct for BAD as a potential confounder... - Peripheral arterial tonometry for risk stratification in men with coronary artery diseaseKevin S Heffernan
The Vascular Function Study Group Division of Cardiology, Tufts Medical Center, Boston, Massachusetts 02111, USA
Clin Cardiol 33:94-8. 2010..Identification of a simple, noninvasive tool that allows for detection of high-risk CAD patients and can be applied in large populations and clinical settings would prove valuable... - Racial differences in central blood pressure and vascular function in young menKevin S Heffernan
Department of Kinesiology and Community Health, Exercise and Cardiovascular Research Laboratory, Rehabilitation Education Center, University of Illinois at Urbana Champaign, 1207 S Oak St Champaign, IL 61820, USA
Am J Physiol Heart Circ Physiol 295:H2380-7. 2008.... 
Arterial wave reflection and vascular autonomic modulation in young and older menKevin S Heffernan
Exercise and Cardiovascular Research Laboratory, and the Exercise Immunology Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL, USA
Aging Clin Exp Res 20:1-7. 2008..The purpose of this study was to examine the relationship between pressure wave reflection and augmentation from peripheral arteries and peripheral sympathetic vasomotion in young and older men...- Influence of arterial wave reflection on carotid blood pressure and intima-media thickness in older endurance trained men and women with pre-hypertensionKevin S Heffernan
The Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL, USA
Clin Physiol Funct Imaging 29:193-200. 2009..The lack of change in carotid SBP and IMT in older ET may be related to the inability of chronic exercise training to reduce bradycardia-related augmented pressure from wave reflections with aging... - C-reactive protein and cardiac vagal activity following resistance exercise training in young African-American and white menKevin S Heffernan
Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
Am J Physiol Regul Integr Comp Physiol 296:R1098-105. 2009..Resistance training may be an important lifestyle modification for improving cardiac autonomic health and reducing inflammation in young African-American men... - Relation of heart rate recovery after exercise to C-reactive protein and white blood cell countSae Young Jae
Department of Kinesiology and Community Health, University of Illinois, Urbana Champaign, USA
Am J Cardiol 99:707-10. 2007..In conclusion, slow and abnormal HRR after exercise testing is associated with inflammatory markers, which could contribute to the high incidence of cardiovascular disease in these subjects... - Association between heart rate recovery after exercise testing and plasminogen activator inhibitor 1, tissue plasminogen activator, and fibrinogen in apparently healthy menSae Young Jae
Department of Kinesiology and Community Health, University of Illinois, Urbana Champaign, 1207 S Oak, St, Champaign, IL 61820, USA
Atherosclerosis 197:415-9. 2008..Because autonomic nervous system function may be associated with fibrinolytic factors, we tested the hypothesis that delayed HRR is associated with elevated fibrinolytic factors... - External mechanical compression reduces regional arterial stiffnessKevin S Heffernan
The Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, Rehabilitation Education Center, University of Illinois at Urbana Champaign, 1207 S Oak St, Champaign, IL 61820, USA
Eur J Appl Physiol 101:735-41. 2007..6 +/- 0.3 m/s to 7.6 +/- 0.3 m/s, P < 0.05). External compression reduced local artery stiffness of the compressed limb while having no effect on arterial stiffness of the non-compressed limb or central artery stiffness... - Impact of excess body weight on arterial structure, function, and blood pressure in firefightersChristopher A Fahs
University of Illinois at Urbana Champaign, Champaign, Illinois, USA
Am J Cardiol 104:1441-5. 2009..In conclusion, in a population of relatively young firefighters, an increased body mass index was associated with elevated peripheral BP and arterial stiffness, with no apparent decrements in endothelial function... - Association between cardiorespiratory fitness and prevalence of carotid atherosclerosis among men with hypertensionSae Young Jae
Department of Kinesiology and Community Health, University of Illinois, Urbana Champaign, IL 61820, USA
Am Heart J 153:1001-5. 2007..We tested the hypothesis that higher levels of cardiorespiratory fitness are inversely associated with the prevalence of carotid atherosclerosis in a cross-sectional study of 2532 (53.2 +/- 8.5 years old) hypertensive men... - Slow heart rate recovery after exercise is associated with carotid atherosclerosisSae Young Jae
Department of Kinesiology and Community Health, University of Illinois, Urbana Champaign, 112 Huff Hall, MC 586, 1206 S Fourth Street, Champaign, IL 61820, USA
Atherosclerosis 196:256-61. 2008..We tested the hypothesis that slow HRR is associated with carotid atherosclerosis in a cross-sectional study of 12,712 middle-aged men (age 49.1+/-8.9 years)... - Racial differences in arterial stiffness after exercise in young menKevin S Heffernan
Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, Illinois 61820, USA
Am J Hypertens 20:840-5. 2007..African-American men have stiffer arteries than white men at rest. We sought to test the hypothesis that reductions in stiffness after aerobic exercise may be attenuated in African-American (AA) men compared with white (W) men... - The pulmonary artery pulsatility index identifies severe right ventricular dysfunction in acute inferior myocardial infarctionRavi Korabathina
Division of Cardiology, Tufts Medical Center, Boston, Massachusetts 02111, USA
Catheter Cardiovasc Interv 80:593-600. 2012..We defined a novel hemodynamic index, the pulmonary artery pulsatility index (PAPi), and explored whether the PAPi correlates with severe RVD in acute IWMI... - Fractal scaling properties of heart rate dynamics following resistance exercise trainingKevin S Heffernan
The Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
J Appl Physiol 105:109-13. 2008..73 +/- 0.04 to 0.69 +/- 0.04 to 0.88 +/- 0.04) and alpha(s) decreased following RT in the higher alpha(s) group (n = 16; 1.20 +/- 0.04 to 1.24 +/- 0.04 to 0.98 +/- 0.04). In conclusion, RT improves fractal properties of HR dynamics... - Exaggerated blood pressure response to exercise is associated with carotid atherosclerosis in apparently healthy menSae Young Jae
Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, Illinois, USA
J Hypertens 24:881-7. 2006..It may be an important factor in evaluating hypertension related to target-organ damage... - Muscular strength is inversely associated with aortic stiffness in young menChristopher A Fahs
University of Illinois at Urbana Champaign, Champaign, IL, USA
Med Sci Sports Exerc 42:1619-24. 2010..Paradoxically, strength training may increase central artery stiffness, a predictor of cardiovascular morbidity and mortality. However, the relationship between muscular strength and central arterial stiffness has yet to be defined... - Arterial stiffness following repeated Valsalva maneuvers and resistance exercise in young menKevin S Heffernan
The Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, Exercise and Cardiovascular Research Laboratory, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
Appl Physiol Nutr Metab 32:257-64. 2007..2 m/s). Arterial stiffness increased after repeated VM. Even though presented with a similar BP load, arterial stiffness did not increase after acute RE. These findings suggest a role for VM in acutely altering arterial properties... - Assessment of vascular endothelial function with peripheral arterial tonometry: information at your fingertips?Eshan A Patvardhan
Vascular Function Study Group, Department of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA
Cardiol Rev 18:20-8. 2010..This review highlights techniques for assessing endothelial function, focusing on a novel method of determining peripheral vascular reactivity via arterial tonometry... - Peripheral vascular endothelial function in patients with hypertrophic cardiomyopathyKevin S Heffernan
The Vascular Function Study Group, The Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, Massachusetts, USA
Am J Cardiol 105:112-5. 2010..Patients with HC have impaired peripheral conduit vessel endothelial function, and the magnitude of impairment is similar to that seen in older patients with advanced CAD... - Heart rate recovery and heart rate complexity following resistance exercise training and detraining in young menKevin S Heffernan
Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, IL, USA
Am J Physiol Heart Circ Physiol 293:H3180-6. 2007..These autonomic changes regress shortly after cessation of training... - Complexity of force output during static exercise in individuals with Down syndromeKevin S Heffernan
Department of Kinesiology and Community Health, University of Illinois at Urbana, Champaign, Champaign, Ilinois 61820, USA
J Appl Physiol 106:1227-33. 2009..This would suggest a possible link between premature aging and less complex force output in persons with DS... - Arterial stiffness and wave reflection following exercise in resistance-trained menKevin S Heffernan
The Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
Med Sci Sports Exerc 39:842-8. 2007..We tested the hypothesis that potentially greater tonic arterial stiffness in resistance-trained (RT) men may alter the vascular response to an acute exercise stressor... - Heart rate recovery after exercise is associated with resting QTc interval in young menKevin S Heffernan
Dept of Kinesiology and Community Health, Exercise and Cardiovascular Research Laboratory, Rehabilitation Education Center, University of Illinois at Urbana Champaign, 1207 S Oak St, Champaign, IL 61820, USA
Clin Auton Res 17:356-63. 2007.... - Hemodynamic and vascular response to resistance exercise with L-arginineChristopher A Fahs
Department of Kinesiology and Community Health, Exercise and Cardiovascular Research Laboratory, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
Med Sci Sports Exerc 41:773-9. 2009..It is possible that a reduction in NO bioavailability is responsible for this. The purpose of this study was to examine the effect of acute L-arginine supplementation and resistance exercise on arterial function... - Effect of single-leg resistance exercise on regional arterial stiffnessKevin S Heffernan
The Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, Rehabilitation Education Center, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
Eur J Appl Physiol 98:185-90. 2006..These findings suggest that regional changes rather than systemic alterations may influence arterial stiffness following acute resistance exercise... - Chronotropic response to exercise testing is associated with carotid atherosclerosis in healthy middle-aged menSae Young Jae
Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, College of Applied Life Studies, University of Illinois, Urbana-Champaign, 112 Huff Hall, MC-586, 1206 S. Fourth St Champaign, IL 61820, USA
Eur Heart J 27:954-9. 2006.... - Effects of lifestyle modifications on C-reactive protein: contribution of weight loss and improved aerobic capacitySae Young Jae
Exercise and Cardiovascular Research Lab, Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, IL 61820, USA
Metabolism 55:825-31. 2006..05) and improved Vo(2)peak (P<.01). Thus, lifestyle changes including regular exercise training in overweight and obese adults decreased hs-CRP, and this was associated with weight loss and improved Vo(2)peak... - Microvascular function and ageing L-arginine, tetrahydrobiopterin and the search for the fountain of vascular youthKevin S Heffernan
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL, USA
J Physiol 586:2041-2. 2008 - Augmentation index derived from peripheral arterial tonometry correlates with cardiovascular risk factorsEshan Patvardhan
Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA
Cardiol Res Pract 2011:253758. 2011..05) Conclusion. AIx derived from PAT correlates with cardiac risk factors and CAD. It may be a useful measure of assessing overall risk for coronary artery disease... - Usefulness of soluble endoglin as a noninvasive measure of left ventricular filling pressure in heart failureNavin K Kapur
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
Am J Cardiol 106:1770-6. 2010..sEng levels also decreased in association with a reduced cardiac filling pressure after diuresis. These findings have identified circulating sEng as a sensitive measure of elevated left heart filling pressures... - Elevated soluble fms-like tyrosine kinase-1 levels in acute coronary occlusionNavin K Kapur
Molecular Cardiology Research Institute, Division of Cardiology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
Arterioscler Thromb Vasc Biol 31:443-50. 2011..Early recognition of an acute coronary occlusion (ACO) improves clinical outcomes. Soluble fms-like tyrosine kinase-1 (sFLT1) is an endothelium-derived protein induced by hypoxia. We tested whether sFLT1 levels are elevated in ACO... - Augmentation index and aortic stiffness in bicuspid aortic valve patients with non-dilated proximal aortasPatrick J Warner
Division of Cardiology and Vascular Function Study Group, Tufts Medical Center, Boston, MA, USA
BMC Cardiovasc Disord 13:19. 2013..We hypothesized BAV is associated with abnormal arterial stiffness... - Cardiac autonomic modulation during recovery from acute endurance versus resistance exerciseKevin S Heffernan
Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Exercise and Cardiovascular Research Laboratory, Champaign, IL 61820, USA
Eur J Cardiovasc Prev Rehabil 13:80-6. 2006..The kinetics of parasympathetic reactivation after dynamic endurance exercise have been well elucidated. However, autonomic recovery of cardiac function after resistance exercise is not known...