Kevin S Heffernan

Summary

Affiliation: Tufts Medical Center
Country: USA

Publications

  1. pmc Endothelium-dependent vasodilation is associated with exercise capacity in smokers and non-smokers
    Kevin S Heffernan
    Vascular Function Study Group, Tufts Medical Center, Boston, MA 02111, USA
    Vasc Med 15:119-25. 2010
  2. doi request reprint Resistance exercise training reduces central blood pressure and improves microvascular function in African American and white men
    Kevin S Heffernan
    Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL, United States
    Atherosclerosis 207:220-6. 2009
  3. pmc L-arginine as a nutritional prophylaxis against vascular endothelial dysfunction with aging
    Kevin S Heffernan
    Division of Cardiology, Department of Medicine, The Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    J Cardiovasc Pharmacol Ther 15:17-23. 2010
  4. pmc Peripheral arterial tonometry for risk stratification in men with coronary artery disease
    Kevin S Heffernan
    The Vascular Function Study Group Division of Cardiology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Clin Cardiol 33:94-8. 2010
  5. doi request reprint Effect of atenolol vs metoprolol succinate on vascular function in patients with hypertension
    Kevin S Heffernan
    Vascular Function Study Group, Department of Medicine, Division of Cardiology, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    Clin Cardiol 34:39-44. 2011
  6. pmc Relation of pulse pressure to blood pressure response to exercise in patients with hypertrophic cardiomyopathy
    Kevin S Heffernan
    Hypertrophic Cardiomyopathy Center, Division of Cardiology, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 107:600-3. 2011
  7. doi request reprint Effect of increased preload on the synthesized aortic blood pressure waveform
    Kevin S Heffernan
    Tufts Medical Center, Molecular Cardiology Research Institute and the Dept of Medicine, Division of Cardiology, 800 Washington St, Boston, MA 02111, USA
    J Appl Physiol (1985) 109:484-90. 2010
  8. pmc Pulse wave amplitude is associated with brachial artery diameter: implications for gender differences in microvascular function
    Kevin S Heffernan
    Vascular Function Study Group, Department of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA
    Vasc Med 15:39-45. 2010
  9. pmc Elevated augmentation index derived from peripheral arterial tonometry is associated with abnormal ventricular-vascular coupling
    Kevin S Heffernan
    The Vascular Function Study Group, Division of Cardiology, Tufts Medical Center, Molecular Cardiology Research Institute, Boston, MA 02111, USA
    Clin Physiol Funct Imaging 30:313-7. 2010
  10. ncbi request reprint Racial differences in central blood pressure and vascular function in young men
    Kevin S Heffernan
    Department of Kinesiology and Community Health, Exercise and Cardiovascular Research Laboratory, Rehabilitation Education Center, University of Illinois at Urbana Champaign, 1207 S Oak St Champaign, IL 61820, USA
    Am J Physiol Heart Circ Physiol 295:H2380-7. 2008

Detail Information

Publications41

  1. pmc Endothelium-dependent vasodilation is associated with exercise capacity in smokers and non-smokers
    Kevin S Heffernan
    Vascular Function Study Group, Tufts Medical Center, Boston, MA 02111, USA
    Vasc Med 15:119-25. 2010
    ..Future research is needed to examine if improving endothelial function will lead to concomitant increases in exercise capacity in chronic smokers...
  2. doi request reprint Resistance exercise training reduces central blood pressure and improves microvascular function in African American and white men
    Kevin S Heffernan
    Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL, United States
    Atherosclerosis 207:220-6. 2009
    ..The purpose of this study was to examine the effect of resistance exercise training (RT) on vascular function and central blood pressure (BP) in young (22 years) African American and white men...
  3. pmc L-arginine as a nutritional prophylaxis against vascular endothelial dysfunction with aging
    Kevin S Heffernan
    Division of Cardiology, Department of Medicine, The Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    J Cardiovasc Pharmacol Ther 15:17-23. 2010
    ..Emphasis will be placed on the ability of L-arginine to modulate the vascular inflammatory and systemic hormonal milieu, which in turn may have a positive effect on vascular endothelial function...
  4. pmc Peripheral arterial tonometry for risk stratification in men with coronary artery disease
    Kevin S Heffernan
    The Vascular Function Study Group Division of Cardiology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Clin Cardiol 33:94-8. 2010
    ..Identification of a simple, noninvasive tool that allows for detection of high-risk CAD patients and can be applied in large populations and clinical settings would prove valuable...
  5. doi request reprint Effect of atenolol vs metoprolol succinate on vascular function in patients with hypertension
    Kevin S Heffernan
    Vascular Function Study Group, Department of Medicine, Division of Cardiology, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    Clin Cardiol 34:39-44. 2011
    ..We evaluated the effect of atenolol vs metoprolol succinate on vascular function in patients with essential hypertension...
  6. pmc Relation of pulse pressure to blood pressure response to exercise in patients with hypertrophic cardiomyopathy
    Kevin S Heffernan
    Hypertrophic Cardiomyopathy Center, Division of Cardiology, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 107:600-3. 2011
    ..24 to 18.2, p <0.05). In conclusion, elevations in PP at rest might identify patients with HC at a greater risk of having an ABPR during exercise...
  7. doi request reprint Effect of increased preload on the synthesized aortic blood pressure waveform
    Kevin S Heffernan
    Tufts Medical Center, Molecular Cardiology Research Institute and the Dept of Medicine, Division of Cardiology, 800 Washington St, Boston, MA 02111, USA
    J Appl Physiol (1985) 109:484-90. 2010
    ..These data suggest that in a setting of isolated augmented preload with minimal changes in other potential confounders, the morphology of the synthesized aortic BP waveform and AIx may be related to changes in aortic reservoir function...
  8. pmc Pulse wave amplitude is associated with brachial artery diameter: implications for gender differences in microvascular function
    Kevin S Heffernan
    Vascular Function Study Group, Department of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA
    Vasc Med 15:39-45. 2010
    ..In conclusion, PWA-RHI obtained from PAT is associated with BAD. Studies examining gender differences in microvascular endothelial function with PAT may need to correct for BAD as a potential confounder...
  9. pmc Elevated augmentation index derived from peripheral arterial tonometry is associated with abnormal ventricular-vascular coupling
    Kevin S Heffernan
    The Vascular Function Study Group, Division of Cardiology, Tufts Medical Center, Molecular Cardiology Research Institute, Boston, MA 02111, USA
    Clin Physiol Funct Imaging 30:313-7. 2010
    ..Little is known regarding the physiologic correlates of AIx derived from PAT. In this study, we investigated the relation of PAT-AIx with measures of ventricular-vascular coupling...
  10. ncbi request reprint Racial differences in central blood pressure and vascular function in young men
    Kevin S Heffernan
    Department of Kinesiology and Community Health, Exercise and Cardiovascular Research Laboratory, Rehabilitation Education Center, University of Illinois at Urbana Champaign, 1207 S Oak St Champaign, IL 61820, USA
    Am J Physiol Heart Circ Physiol 295:H2380-7. 2008
    ....
  11. ncbi request reprint Arterial wave reflection and vascular autonomic modulation in young and older men
    Kevin S Heffernan
    Exercise and Cardiovascular Research Laboratory, and the Exercise Immunology Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL, USA
    Aging Clin Exp Res 20:1-7. 2008
    ..The purpose of this study was to examine the relationship between pressure wave reflection and augmentation from peripheral arteries and peripheral sympathetic vasomotion in young and older men...
  12. doi request reprint Influence of arterial wave reflection on carotid blood pressure and intima-media thickness in older endurance trained men and women with pre-hypertension
    Kevin S Heffernan
    The Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL, USA
    Clin Physiol Funct Imaging 29:193-200. 2009
    ..The lack of change in carotid SBP and IMT in older ET may be related to the inability of chronic exercise training to reduce bradycardia-related augmented pressure from wave reflections with aging...
  13. doi request reprint C-reactive protein and cardiac vagal activity following resistance exercise training in young African-American and white men
    Kevin S Heffernan
    Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1098-105. 2009
    ..Resistance training may be an important lifestyle modification for improving cardiac autonomic health and reducing inflammation in young African-American men...
  14. ncbi request reprint External mechanical compression reduces regional arterial stiffness
    Kevin S Heffernan
    The Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, Rehabilitation Education Center, University of Illinois at Urbana Champaign, 1207 S Oak St, Champaign, IL 61820, USA
    Eur J Appl Physiol 101:735-41. 2007
    ..6 +/- 0.3 m/s to 7.6 +/- 0.3 m/s, P < 0.05). External compression reduced local artery stiffness of the compressed limb while having no effect on arterial stiffness of the non-compressed limb or central artery stiffness...
  15. doi request reprint Impact of excess body weight on arterial structure, function, and blood pressure in firefighters
    Christopher A Fahs
    University of Illinois at Urbana Champaign, Champaign, Illinois, USA
    Am J Cardiol 104:1441-5. 2009
    ..In conclusion, in a population of relatively young firefighters, an increased body mass index was associated with elevated peripheral BP and arterial stiffness, with no apparent decrements in endothelial function...
  16. ncbi request reprint Relation of heart rate recovery after exercise to C-reactive protein and white blood cell count
    Sae Young Jae
    Department of Kinesiology and Community Health, University of Illinois, Urbana Champaign, USA
    Am J Cardiol 99:707-10. 2007
    ..In conclusion, slow and abnormal HRR after exercise testing is associated with inflammatory markers, which could contribute to the high incidence of cardiovascular disease in these subjects...
  17. ncbi request reprint Exaggerated blood pressure response to exercise is associated with carotid atherosclerosis in apparently healthy men
    Sae Young Jae
    Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, University of Illinois, Urbana Champaign, Illinois, USA
    J Hypertens 24:881-7. 2006
    ..We tested the hypothesis that an exaggerated SBP response is associated with carotid atherosclerosis in a cross-sectional study of 9073 healthy men (aged 47.8 +/- 8.8 years)...
  18. ncbi request reprint Racial differences in arterial stiffness after exercise in young men
    Kevin S Heffernan
    Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, Illinois 61820, USA
    Am J Hypertens 20:840-5. 2007
    ..African-American men have stiffer arteries than white men at rest. We sought to test the hypothesis that reductions in stiffness after aerobic exercise may be attenuated in African-American (AA) men compared with white (W) men...
  19. ncbi request reprint Slow heart rate recovery after exercise is associated with carotid atherosclerosis
    Sae Young Jae
    Department of Kinesiology and Community Health, University of Illinois, Urbana Champaign, 112 Huff Hall, MC 586, 1206 S Fourth Street, Champaign, IL 61820, USA
    Atherosclerosis 196:256-61. 2008
    ..We tested the hypothesis that slow HRR is associated with carotid atherosclerosis in a cross-sectional study of 12,712 middle-aged men (age 49.1+/-8.9 years)...
  20. ncbi request reprint Association between cardiorespiratory fitness and prevalence of carotid atherosclerosis among men with hypertension
    Sae Young Jae
    Department of Kinesiology and Community Health, University of Illinois, Urbana Champaign, IL 61820, USA
    Am Heart J 153:1001-5. 2007
    ..We tested the hypothesis that higher levels of cardiorespiratory fitness are inversely associated with the prevalence of carotid atherosclerosis in a cross-sectional study of 2532 (53.2 +/- 8.5 years old) hypertensive men...
  21. ncbi request reprint Association between heart rate recovery after exercise testing and plasminogen activator inhibitor 1, tissue plasminogen activator, and fibrinogen in apparently healthy men
    Sae Young Jae
    Department of Kinesiology and Community Health, University of Illinois, Urbana Champaign, 1207 S Oak, St, Champaign, IL 61820, USA
    Atherosclerosis 197:415-9. 2008
    ..Because autonomic nervous system function may be associated with fibrinolytic factors, we tested the hypothesis that delayed HRR is associated with elevated fibrinolytic factors...
  22. doi request reprint The pulmonary artery pulsatility index identifies severe right ventricular dysfunction in acute inferior myocardial infarction
    Ravi Korabathina
    Division of Cardiology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Catheter Cardiovasc Interv 80:593-600. 2012
    ..We defined a novel hemodynamic index, the pulmonary artery pulsatility index (PAPi), and explored whether the PAPi correlates with severe RVD in acute IWMI...
  23. doi request reprint Fractal scaling properties of heart rate dynamics following resistance exercise training
    Kevin S Heffernan
    The Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    J Appl Physiol (1985) 105:109-13. 2008
    ..73 +/- 0.04 to 0.69 +/- 0.04 to 0.88 +/- 0.04) and alpha(s) decreased following RT in the higher alpha(s) group (n = 16; 1.20 +/- 0.04 to 1.24 +/- 0.04 to 0.98 +/- 0.04). In conclusion, RT improves fractal properties of HR dynamics...
  24. ncbi request reprint Arterial stiffness following repeated Valsalva maneuvers and resistance exercise in young men
    Kevin S Heffernan
    The Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, Exercise and Cardiovascular Research Laboratory, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    Appl Physiol Nutr Metab 32:257-64. 2007
    ..2 m/s). Arterial stiffness increased after repeated VM. Even though presented with a similar BP load, arterial stiffness did not increase after acute RE. These findings suggest a role for VM in acutely altering arterial properties...
  25. doi request reprint Assessment of vascular endothelial function with peripheral arterial tonometry: information at your fingertips?
    Eshan A Patvardhan
    Vascular Function Study Group, Department of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA
    Cardiol Rev 18:20-8. 2010
    ..This review highlights techniques for assessing endothelial function, focusing on a novel method of determining peripheral vascular reactivity via arterial tonometry...
  26. doi request reprint Muscular strength is inversely associated with aortic stiffness in young men
    Christopher A Fahs
    University of Illinois at Urbana Champaign, Champaign, IL, USA
    Med Sci Sports Exerc 42:1619-24. 2010
    ..Paradoxically, strength training may increase central artery stiffness, a predictor of cardiovascular morbidity and mortality. However, the relationship between muscular strength and central arterial stiffness has yet to be defined...
  27. pmc Peripheral vascular endothelial function in patients with hypertrophic cardiomyopathy
    Kevin S Heffernan
    The Vascular Function Study Group, The Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 105:112-5. 2010
    ..Patients with HC have impaired peripheral conduit vessel endothelial function, and the magnitude of impairment is similar to that seen in older patients with advanced CAD...
  28. ncbi request reprint Heart rate recovery and heart rate complexity following resistance exercise training and detraining in young men
    Kevin S Heffernan
    Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, IL, USA
    Am J Physiol Heart Circ Physiol 293:H3180-6. 2007
    ..These autonomic changes regress shortly after cessation of training...
  29. pmc Augmentation index and aortic stiffness in bicuspid aortic valve patients with non-dilated proximal aortas
    Patrick J Warner
    Division of Cardiology and Vascular Function Study Group, Tufts Medical Center, Boston, MA, USA
    BMC Cardiovasc Disord 13:19. 2013
    ..We hypothesized BAV is associated with abnormal arterial stiffness...
  30. ncbi request reprint Arterial stiffness and wave reflection following exercise in resistance-trained men
    Kevin S Heffernan
    The Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    Med Sci Sports Exerc 39:842-8. 2007
    ..We tested the hypothesis that potentially greater tonic arterial stiffness in resistance-trained (RT) men may alter the vascular response to an acute exercise stressor...
  31. pmc Complexity of force output during static exercise in individuals with Down syndrome
    Kevin S Heffernan
    Department of Kinesiology and Community Health, University of Illinois at Urbana, Champaign, Champaign, Ilinois 61820, USA
    J Appl Physiol (1985) 106:1227-33. 2009
    ..This would suggest a possible link between premature aging and less complex force output in persons with DS...
  32. ncbi request reprint Heart rate recovery after exercise is associated with resting QTc interval in young men
    Kevin S Heffernan
    Dept of Kinesiology and Community Health, Exercise and Cardiovascular Research Laboratory, Rehabilitation Education Center, University of Illinois at Urbana Champaign, 1207 S Oak St, Champaign, IL 61820, USA
    Clin Auton Res 17:356-63. 2007
    ....
  33. doi request reprint Hemodynamic and vascular response to resistance exercise with L-arginine
    Christopher A Fahs
    Department of Kinesiology and Community Health, Exercise and Cardiovascular Research Laboratory, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    Med Sci Sports Exerc 41:773-9. 2009
    ..It is possible that a reduction in NO bioavailability is responsible for this. The purpose of this study was to examine the effect of acute L-arginine supplementation and resistance exercise on arterial function...
  34. ncbi request reprint Effect of single-leg resistance exercise on regional arterial stiffness
    Kevin S Heffernan
    The Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, Rehabilitation Education Center, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    Eur J Appl Physiol 98:185-90. 2006
    ..These findings suggest that regional changes rather than systemic alterations may influence arterial stiffness following acute resistance exercise...
  35. ncbi request reprint Chronotropic response to exercise testing is associated with carotid atherosclerosis in healthy middle-aged men
    Sae Young Jae
    Exercise and Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, College of Applied Life Studies, University of Illinois, Urbana Champaign, 112 Huff Hall, MC 586, 1206 S Fourth St Champaign, IL 61820, USA
    Eur Heart J 27:954-9. 2006
    ..The association between chronotropic incompetence and carotid atherosclerosis in 8567 (age 47.6+/-8.8 years) healthy men was examined...
  36. ncbi request reprint Effects of lifestyle modifications on C-reactive protein: contribution of weight loss and improved aerobic capacity
    Sae Young Jae
    Exercise and Cardiovascular Research Lab, Department of Kinesiology and Community Health, University of Illinois, Urbana Champaign, IL 61820, USA
    Metabolism 55:825-31. 2006
    ..05) and improved Vo(2)peak (P<.01). Thus, lifestyle changes including regular exercise training in overweight and obese adults decreased hs-CRP, and this was associated with weight loss and improved Vo(2)peak...
  37. pmc Microvascular function and ageing L-arginine, tetrahydrobiopterin and the search for the fountain of vascular youth
    Kevin S Heffernan
    Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL, USA
    J Physiol 586:2041-2. 2008
  38. pmc Augmentation index derived from peripheral arterial tonometry correlates with cardiovascular risk factors
    Eshan Patvardhan
    Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA
    Cardiol Res Pract 2011:253758. 2011
    ..05) Conclusion. AIx derived from PAT correlates with cardiac risk factors and CAD. It may be a useful measure of assessing overall risk for coronary artery disease...
  39. pmc Usefulness of soluble endoglin as a noninvasive measure of left ventricular filling pressure in heart failure
    Navin K Kapur
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 106:1770-6. 2010
    ..sEng levels also decreased in association with a reduced cardiac filling pressure after diuresis. These findings have identified circulating sEng as a sensitive measure of elevated left heart filling pressures...
  40. doi request reprint Elevated soluble fms-like tyrosine kinase-1 levels in acute coronary occlusion
    Navin K Kapur
    Molecular Cardiology Research Institute, Division of Cardiology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 31:443-50. 2011
    ..Early recognition of an acute coronary occlusion (ACO) improves clinical outcomes. Soluble fms-like tyrosine kinase-1 (sFLT1) is an endothelium-derived protein induced by hypoxia. We tested whether sFLT1 levels are elevated in ACO...
  41. ncbi request reprint Cardiac autonomic modulation during recovery from acute endurance versus resistance exercise
    Kevin S Heffernan
    Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Exercise and Cardiovascular Research Laboratory, Champaign, IL 61820, USA
    Eur J Cardiovasc Prev Rehabil 13:80-6. 2006
    ..The kinetics of parasympathetic reactivation after dynamic endurance exercise have been well elucidated. However, autonomic recovery of cardiac function after resistance exercise is not known...