Research Topics
Genomes and Genes
Species | Akiko HataSummaryAffiliation: Tufts University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Regulation of pri-miRNA processing through SmadsAkiko Hata
Department of Biochemistry, Tufts University School of Medicine and Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
Adv Exp Med Biol 700:15-27. 2010....
Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleusAkiko Hata
Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, United States
Cytokine Growth Factor Rev 20:517-21. 2009..In this review, we summarize the current understanding of the regulation of miRNA biogenesis mediated by the TGFbeta signaling pathway...
Regulation of pri-miRNA Processing Through SmadsAkiko Hata
800 Washington Street, Box 8486, Boston, MA, 02111, USA
Adv Exp Med Biol 700:15-27. 2011....- down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4Brandi N Davis-Dusenbery
Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 286:28097-110. 2011..Thus, this study sheds light on both the similarities and the differences of TGF-β and BMP4 signaling in the regulation of KLF4 and contractile genes... - The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular toneNicole A Neuman
Department of Biochemistry, Tufts University School of Medicine, Tufts Medical Center, Boston, MA 02111, USA
J Biol Chem 284:13202-12. 2009..Finally, aortic rings from homozygous FHL2-null mice display abnormalities in both endothelial-dependent and -independent relaxation, suggesting that FHL2 is essential for the regulation of vasomotor tone... - Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteinsHara Kang
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111, USA
J Biol Chem 287:3976-86. 2012..Thus, this study uncovers a regulatory mechanism of the vSMC phenotype by the BMP4-miR-21 axis through DOCK family proteins... - Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2Connie Wu
Graduate Program in Biochemistry, Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts 02111, USA
Mol Cell Biol 31:4760-74. 2011.... - A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptorMun Chun Chan
Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Mol Cell Biol 27:5776-89. 2007..Thus, Trb3 is a critical component of a novel mechanism for regulation of the BMP pathway by BMPRII... - Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expressionMun Chun Chan
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
EMBO J 29:559-73. 2010..Thus, this study provides a molecular basis for the antagonism between the PDGF and TGFbeta pathways, and its effect on the control of the vSMC phenotype... - The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathwayMun Chun Chan
Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box 8486, Boston, MA 02111, USA
Mol Cell Biol 31:517-30. 2011..These results indicate that constitutive elevation of Trb3 by phenamil is a potential therapy for IPAH and FPAH... - Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotypeBrandi N Davis
Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts, USA
J Biol Chem 284:3728-38. 2009..Our study demonstrates that PDGF signaling, by modulating the expression of miR-221, regulates two critical determinants of the vSMC phenotype; they are SMC gene expression and cell proliferation... - Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factorsGiorgio Lagna
Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
J Biol Chem 282:37244-55. 2007..Thus, BMP signaling modulates VSMC phenotype via cross-talk with the RhoA/MRTFs pathway, and may contribute to the development of the pathological characteristics observed in patients with PAH and other obliterative vascular diseases... - OAZ regulates bone morphogenetic protein signaling through Smad6 activationManching Ku
Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
J Biol Chem 281:5277-87. 2006..Our results demonstrate that OAZ can alter the intensity and duration of the BMP stimulus through Smad6 and indicate that the tissue-specific expression of OAZ is a critical determinant of the cellular response to the BMP signal... - Smad proteins bind a conserved RNA sequence to promote microRNA maturation by DroshaBrandi N Davis
Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA
Mol Cell 39:373-84. 2010..Thus, Smads are multifunctional proteins that modulate gene expression transcriptionally through DNA binding and posttranscriptionally through pri-miRNA binding and regulation of miRNA processing... - SMAD proteins control DROSHA-mediated microRNA maturationBrandi N Davis
Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Nature 454:56-61. 2008.... - Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathwayHara Kang
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111, USA
J Biol Chem 287:38656-64. 2012..We propose that the negative regulatory loop of BMP4-miR-302-BMPRII is a potential mechanism for the maintenance and fine-tuning of the BMP signaling pathway in various systems... - Smad-mediated miRNA processing: a critical role for a conserved RNA sequenceBrandi N Davis-Dusenbery
Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
RNA Biol 8:71-6. 2011..In this review we discuss the role of the Smads in the regulation of miRNA processing in response to Transforming Growth Factor-β stimulation... - Micromanaging vascular smooth muscle cell differentiation and phenotypic modulationBrandi N Davis-Dusenbery
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA
Arterioscler Thromb Vasc Biol 31:2370-7. 2011..Individual miRNAs are involved in promoting both contractile and synthetic VSMC phenotype. In this review, we summarize recent advances in the understanding of miRNA function in the regulation of VSMC phenotype regulation... - BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cellsGiorgio Lagna
Molecular Cardiology Research Institute, Tufts New England Medical Center, 750 Washington St, Boston, MA 02111, USA
Am J Physiol Lung Cell Mol Physiol 291:L1059-67. 2006..Our study also demonstrates an essential role of the carboxy terminus domain of BMPRII in the activation of the apoptotic signaling cascade... - Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor ADahai Wang
Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 287:28067-77. 2012..Thus, a molecular inhibitory pathway linking BMP4 signaling, activation of MRTF-A, and inhibition of NF-κB provides insights into the etiology of PAH and a potential focus of therapeutic intervention... - Mechanisms of control of microRNA biogenesisBrandi N Davis-Dusenbery
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
J Biochem 148:381-92. 2010.... - Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factorsManching Ku
Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
Mol Cell Biol 25:7144-57. 2005..These results suggest a model in which TFII-I family proteins have opposing effects in the regulation of the Gsc gene in response to a TGFbeta/activin signal... - Regulation of MicroRNA Biogenesis: A miRiad of mechanismsBrandi N Davis
Department of Biochemistry, Tufts University School of Medicine, Boston MA 02111, USA
Cell Commun Signal 7:18. 2009..Further understanding of the regulation of microRNA biogenesis and activity will undoubtedly provide important insights into normal development as well as pathological conditions such as cardiovascular disease and cancer... - MicroRNA in Cancer: The Involvement of Aberrant MicroRNA Biogenesis Regulatory PathwaysBrandi N Davis-Dusenbery
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA
Genes Cancer 1:1100-14. 2010..In this review, we discuss the mechanisms that govern the regulation of miRNA biogenesis with particular focus on how these mechanisms are perturbed in cancer... - Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathwayKenji Seki
Molecular Cardiology Research Institute, Tufts New England Medical Center, Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 279:18544-9. 2004..These findings indicate that BMP stimulates Ihh expression. We also suggest expression of the Ihh gene, which contains multiple Smad binding sites, might be finely regulated by a gradient of BMP concentrations... - Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genesMan ching Ku
Molecular Cardiology Research Institute, Tufts New England Medical Center and Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA
Biochem Biophys Res Commun 311:702-7. 2003..These results suggest that Parp1 serves as a transcriptional coactivator of OAZ in BMP-dependent gene regulation... - Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecanKenji Seki
Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
J Biol Chem 278:41862-70. 2003..Because type II collagen and aggrecan are major functional components of extracellular matrix in cartilage, these results suggest an important role for Snail-related transcription repressors during chondrocyte differentiation...
Research Grants
- Mechanisms of TGFB Signal TransductionAkiko Hata; Fiscal Year: 2007..These studies should provide important insights into TGFbeta-mediated regulation of gene expression, which is of direct relevance to both normal physiology and a variety of disease states. ..
- Role of miRNAs in Vascular PhysiologyAkiko Hata; Fiscal Year: 2010..This application will elucidate a novel mechanism of regulation of VSMC phenotype in normal physiology, which is of fundamental importance in understanding the etiology of cardiovascular disorders. ..
- Role of miRNAs in Vascular PhysiologyAkiko Hata; Fiscal Year: 2009..This application will elucidate a novel mechanism of regulation of VSMC phenotype in normal physiology, which is of fundamental importance in understanding the etiology of cardiovascular disorders. ..
- Role of BMPRII Mutants in the Pathogenesis of Pulmonary HypertensionAkiko Hata; Fiscal Year: 2009....
- Role of BMPRII Mutants in the Pathogenesis of Pulmonary HypertensionAkiko Hata; Fiscal Year: 2007....