Akiko Hata

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi Regulation of pri-miRNA processing through Smads
    Akiko Hata
    Department of Biochemistry, Tufts University School of Medicine and Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    Adv Exp Med Biol 700:15-27. 2010
  2. doi Regulation of pri-miRNA Processing Through Smads
    Akiko Hata
    800 Washington Street, Box 8486, Boston, MA, 02111, USA
    Adv Exp Med Biol 700:15-27. 2011
  3. pmc Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus
    Akiko Hata
    Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, United States
    Cytokine Growth Factor Rev 20:517-21. 2009
  4. pmc down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4
    Brandi N Davis-Dusenbery
    Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 286:28097-110. 2011
  5. pmc The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone
    Nicole A Neuman
    Department of Biochemistry, Tufts University School of Medicine, Tufts Medical Center, Boston, MA 02111, USA
    J Biol Chem 284:13202-12. 2009
  6. pmc Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins
    Hara Kang
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 287:3976-86. 2012
  7. pmc Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2
    Connie Wu
    Graduate Program in Biochemistry, Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts 02111, USA
    Mol Cell Biol 31:4760-74. 2011
  8. pmc A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor
    Mun Chun Chan
    Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 27:5776-89. 2007
  9. pmc Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression
    Mun Chun Chan
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    EMBO J 29:559-73. 2010
  10. pmc The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway
    Mun Chun Chan
    Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box 8486, Boston, MA 02111, USA
    Mol Cell Biol 31:517-30. 2011

Collaborators

Detail Information

Publications29

  1. ncbi Regulation of pri-miRNA processing through Smads
    Akiko Hata
    Department of Biochemistry, Tufts University School of Medicine and Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    Adv Exp Med Biol 700:15-27. 2010
    ....
  2. doi Regulation of pri-miRNA Processing Through Smads
    Akiko Hata
    800 Washington Street, Box 8486, Boston, MA, 02111, USA
    Adv Exp Med Biol 700:15-27. 2011
    ....
  3. pmc Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus
    Akiko Hata
    Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, United States
    Cytokine Growth Factor Rev 20:517-21. 2009
    ..In this review, we summarize the current understanding of the regulation of miRNA biogenesis mediated by the TGFbeta signaling pathway...
  4. pmc down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4
    Brandi N Davis-Dusenbery
    Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 286:28097-110. 2011
    ..Thus, this study sheds light on both the similarities and the differences of TGF-β and BMP4 signaling in the regulation of KLF4 and contractile genes...
  5. pmc The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone
    Nicole A Neuman
    Department of Biochemistry, Tufts University School of Medicine, Tufts Medical Center, Boston, MA 02111, USA
    J Biol Chem 284:13202-12. 2009
    ..Finally, aortic rings from homozygous FHL2-null mice display abnormalities in both endothelial-dependent and -independent relaxation, suggesting that FHL2 is essential for the regulation of vasomotor tone...
  6. pmc Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins
    Hara Kang
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 287:3976-86. 2012
    ..Thus, this study uncovers a regulatory mechanism of the vSMC phenotype by the BMP4-miR-21 axis through DOCK family proteins...
  7. pmc Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2
    Connie Wu
    Graduate Program in Biochemistry, Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts 02111, USA
    Mol Cell Biol 31:4760-74. 2011
    ....
  8. pmc A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor
    Mun Chun Chan
    Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 27:5776-89. 2007
    ..Thus, Trb3 is a critical component of a novel mechanism for regulation of the BMP pathway by BMPRII...
  9. pmc Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression
    Mun Chun Chan
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    EMBO J 29:559-73. 2010
    ..Thus, this study provides a molecular basis for the antagonism between the PDGF and TGFbeta pathways, and its effect on the control of the vSMC phenotype...
  10. pmc The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway
    Mun Chun Chan
    Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box 8486, Boston, MA 02111, USA
    Mol Cell Biol 31:517-30. 2011
    ..These results indicate that constitutive elevation of Trb3 by phenamil is a potential therapy for IPAH and FPAH...
  11. pmc Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha
    Brandi N Davis
    Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA
    Mol Cell 39:373-84. 2010
    ..Thus, Smads are multifunctional proteins that modulate gene expression transcriptionally through DNA binding and posttranscriptionally through pri-miRNA binding and regulation of miRNA processing...
  12. ncbi OAZ regulates bone morphogenetic protein signaling through Smad6 activation
    Manching Ku
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    J Biol Chem 281:5277-87. 2006
    ..Our results demonstrate that OAZ can alter the intensity and duration of the BMP stimulus through Smad6 and indicate that the tissue-specific expression of OAZ is a critical determinant of the cellular response to the BMP signal...
  13. pmc Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype
    Brandi N Davis
    Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Biol Chem 284:3728-38. 2009
    ..Our study demonstrates that PDGF signaling, by modulating the expression of miR-221, regulates two critical determinants of the vSMC phenotype; they are SMC gene expression and cell proliferation...
  14. pmc Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors
    Giorgio Lagna
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    J Biol Chem 282:37244-55. 2007
    ..Thus, BMP signaling modulates VSMC phenotype via cross-talk with the RhoA/MRTFs pathway, and may contribute to the development of the pathological characteristics observed in patients with PAH and other obliterative vascular diseases...
  15. pmc Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway
    Hara Kang
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 287:38656-64. 2012
    ..We propose that the negative regulatory loop of BMP4-miR-302-BMPRII is a potential mechanism for the maintenance and fine-tuning of the BMP signaling pathway in various systems...
  16. pmc SMAD proteins control DROSHA-mediated microRNA maturation
    Brandi N Davis
    Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nature 454:56-61. 2008
    ....
  17. pmc Atrial natriuretic peptide is negatively regulated by microRNA-425
    Pankaj Arora
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 123:3378-82. 2013
    ..This study identifies miR-425 as a regulator of ANP production, raising the possibility that miR-425 antagonists could be used to treat disorders of salt overload, including hypertension and heart failure. ..
  18. pmc Smad-mediated miRNA processing: a critical role for a conserved RNA sequence
    Brandi N Davis-Dusenbery
    Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
    RNA Biol 8:71-6. 2011
    ..In this review we discuss the role of the Smads in the regulation of miRNA processing in response to Transforming Growth Factor-β stimulation...
  19. doi Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation
    Brandi N Davis-Dusenbery
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 31:2370-7. 2011
    ..Individual miRNAs are involved in promoting both contractile and synthetic VSMC phenotype. In this review, we summarize recent advances in the understanding of miRNA function in the regulation of VSMC phenotype regulation...
  20. ncbi BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells
    Giorgio Lagna
    Molecular Cardiology Research Institute, Tufts New England Medical Center, 750 Washington St, Boston, MA 02111, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1059-67. 2006
    ..Our study also demonstrates an essential role of the carboxy terminus domain of BMPRII in the activation of the apoptotic signaling cascade...
  21. pmc Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress
    Jonathan Chang
    1 Cardiovascular Research Institute, University of California, San Francisco, CA, USA 2 Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA 3 Department of Biochemistry, Tufts University School of Medicine, Boston, MA, USA
    EMBO J 32:3192-205. 2013
    ....
  22. pmc Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A
    Dahai Wang
    Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 287:28067-77. 2012
    ..Thus, a molecular inhibitory pathway linking BMP4 signaling, activation of MRTF-A, and inhibition of NF-κB provides insights into the etiology of PAH and a potential focus of therapeutic intervention...
  23. pmc Mechanisms of control of microRNA biogenesis
    Brandi N Davis-Dusenbery
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    J Biochem 148:381-92. 2010
    ....
  24. pmc Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors
    Manching Ku
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    Mol Cell Biol 25:7144-57. 2005
    ..These results suggest a model in which TFII-I family proteins have opposing effects in the regulation of the Gsc gene in response to a TGFbeta/activin signal...
  25. pmc MicroRNA in Cancer: The Involvement of Aberrant MicroRNA Biogenesis Regulatory Pathways
    Brandi N Davis-Dusenbery
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA
    Genes Cancer 1:1100-14. 2010
    ..In this review, we discuss the mechanisms that govern the regulation of miRNA biogenesis with particular focus on how these mechanisms are perturbed in cancer...
  26. pmc Regulation of MicroRNA Biogenesis: A miRiad of mechanisms
    Brandi N Davis
    Department of Biochemistry, Tufts University School of Medicine, Boston MA 02111, USA
    Cell Commun Signal 7:18. 2009
    ..Further understanding of the regulation of microRNA biogenesis and activity will undoubtedly provide important insights into normal development as well as pathological conditions such as cardiovascular disease and cancer...
  27. ncbi Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway
    Kenji Seki
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 279:18544-9. 2004
    ..These findings indicate that BMP stimulates Ihh expression. We also suggest expression of the Ihh gene, which contains multiple Smad binding sites, might be finely regulated by a gradient of BMP concentrations...
  28. ncbi Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes
    Man ching Ku
    Molecular Cardiology Research Institute, Tufts New England Medical Center and Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA
    Biochem Biophys Res Commun 311:702-7. 2003
    ..These results suggest that Parp1 serves as a transcriptional coactivator of OAZ in BMP-dependent gene regulation...
  29. pmc Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan
    Kenji Seki
    Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 278:41862-70. 2003
    ..Because type II collagen and aggrecan are major functional components of extracellular matrix in cartilage, these results suggest an important role for Snail-related transcription repressors during chondrocyte differentiation...

Research Grants11

  1. Mechanisms of TGFB Signal Transduction
    Akiko Hata; Fiscal Year: 2007
    ..These studies should provide important insights into TGFbeta-mediated regulation of gene expression, which is of direct relevance to both normal physiology and a variety of disease states. ..
  2. Role of miRNAs in Vascular Physiology
    Akiko Hata; Fiscal Year: 2010
    ..This application will elucidate a novel mechanism of regulation of VSMC phenotype in normal physiology, which is of fundamental importance in understanding the etiology of cardiovascular disorders. ..
  3. Mechanisms of TGFB Signal Transduction
    Akiko Hata; Fiscal Year: 2003
    ..These studies should provide important insights into TGFbeta-mediated regulation of gene expression, which is of direct relevance to both normal physiology and a variety of disease states. ..
  4. Role of miRNAs in Vascular Physiology
    Akiko Hata; Fiscal Year: 2009
    ..This application will elucidate a novel mechanism of regulation of VSMC phenotype in normal physiology, which is of fundamental importance in understanding the etiology of cardiovascular disorders. ..
  5. Role of BMPRII Mutants in the Pathogenesis of Pulmonary Hypertension
    Akiko Hata; Fiscal Year: 2009
    ....
  6. Role of BMPRII Mutants in the Pathogenesis of Pulmonary Hypertension
    Akiko Hata; Fiscal Year: 2007
    ....
  7. Role of BMPRII Mutants in the Pathogenesis of Pulmonary Hypertension
    Akiko Hata; Fiscal Year: 2006
    ....
  8. Mechanisms of TGFB Signal Transduction
    Akiko Hata; Fiscal Year: 2006
    ..These studies should provide important insights into TGFbeta-mediated regulation of gene expression, which is of direct relevance to both normal physiology and a variety of disease states. ..
  9. Mechanisms of TGFB Signal Transduction
    Akiko Hata; Fiscal Year: 2005
    ..These studies should provide important insights into TGFbeta-mediated regulation of gene expression, which is of direct relevance to both normal physiology and a variety of disease states. ..
  10. Mechanisms of TGFB Signal Transduction
    Akiko Hata; Fiscal Year: 2004
    ..These studies should provide important insights into TGFbeta-mediated regulation of gene expression, which is of direct relevance to both normal physiology and a variety of disease states. ..