S N Ghaemi

Summary

Affiliation: Tufts Medical Center
Country: USA

Publications

  1. pmc Long-term antidepressant treatment in bipolar disorder: meta-analyses of benefits and risks
    S N Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Boston, MA 02111, USA
    Acta Psychiatr Scand 118:347-56. 2008
  2. pmc Publication bias and the pharmaceutical industry: the case of lamotrigine in bipolar disorder
    S Nassir Ghaemi
    Tufts Medical Center, Boston, Massachusetts, USA
    Medscape J Med 10:211. 2008
  3. doi request reprint Why antidepressants are not antidepressants: STEP-BD, STAR*D, and the return of neurotic depression
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington Street, 1007, Boston, MA 02111, USA
    Bipolar Disord 10:957-68. 2008
  4. doi request reprint The varieties of depressive experience: diagnosing mood disorders
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street 1007, Boston, MA 02111, USA
    Psychiatr Clin North Am 35:73-86. 2012
  5. doi request reprint A double-blind, placebo-controlled pilot study of galantamine to improve cognitive dysfunction in minimally symptomatic bipolar disorder
    S Nassir Ghaemi
    Department of Psychiatry, Mood Disorders Program, Tufts Medical Center, Boston, MA, USA
    J Clin Psychopharmacol 29:291-5. 2009
  6. pmc Nosologomania: DSM & Karl Jaspers' critique of Kraepelin
    S Nassir Ghaemi
    Mood Disorders Program, Mood Disorders Clinic, Department of Psychiatry, Tufts Medical Center, 800 Washington Street, Box 1007, Boston, MA 02111, USA
    Philos Ethics Humanit Med 4:10. 2009
  7. doi request reprint Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safety
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington St, Box 1007, Boston, MA 02111, USA
    J Clin Psychiatry 71:372-80. 2010
  8. ncbi request reprint The impact of the discovery of lithium on psychiatric thought and practice in the USA and Europe
    F K Goodwin
    Department of Psychiatry, George Washington University, Washington, DC 20037, USA
    Aust N Z J Psychiatry 33:S54-64. 1999
  9. doi request reprint A prospective, open-label study of Aripiprazole mono- and adjunctive treatment in acute bipolar depression
    Robert T Dunn
    Psychopharmacology Research Program, Cambridge Health Alliance, Cambridge, MA, USA
    J Affect Disord 110:70-4. 2008
  10. ncbi request reprint Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD
    Joseph F Goldberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Clin Psychiatry 70:155-62. 2009

Collaborators

Detail Information

Publications45

  1. pmc Long-term antidepressant treatment in bipolar disorder: meta-analyses of benefits and risks
    S N Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Boston, MA 02111, USA
    Acta Psychiatr Scand 118:347-56. 2008
    ..Long-term antidepressant (AD) treatment for depression in bipolar disorder (BPD) patients is highly prevalent, but its benefits and risks remain uncertain, encouraging this meta-analysis of available research...
  2. pmc Publication bias and the pharmaceutical industry: the case of lamotrigine in bipolar disorder
    S Nassir Ghaemi
    Tufts Medical Center, Boston, Massachusetts, USA
    Medscape J Med 10:211. 2008
    ....
  3. doi request reprint Why antidepressants are not antidepressants: STEP-BD, STAR*D, and the return of neurotic depression
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington Street, 1007, Boston, MA 02111, USA
    Bipolar Disord 10:957-68. 2008
    ..Diagnostic criteria for a revival of the concept of neurotic depression are proposed...
  4. doi request reprint The varieties of depressive experience: diagnosing mood disorders
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street 1007, Boston, MA 02111, USA
    Psychiatr Clin North Am 35:73-86. 2012
    ..The authors propose a return to careful psychopathology as the basis of all nosology, which has led to identifying four main types of depressive illness, and a method-based, existential approach to understanding depression...
  5. doi request reprint A double-blind, placebo-controlled pilot study of galantamine to improve cognitive dysfunction in minimally symptomatic bipolar disorder
    S Nassir Ghaemi
    Department of Psychiatry, Mood Disorders Program, Tufts Medical Center, Boston, MA, USA
    J Clin Psychopharmacol 29:291-5. 2009
    ..In addition, the effect of galantamine on clinical measures of functioning and psychopathology was assessed...
  6. pmc Nosologomania: DSM & Karl Jaspers' critique of Kraepelin
    S Nassir Ghaemi
    Mood Disorders Program, Mood Disorders Clinic, Department of Psychiatry, Tufts Medical Center, 800 Washington Street, Box 1007, Boston, MA 02111, USA
    Philos Ethics Humanit Med 4:10. 2009
    ..Jaspers' critique of Kraepelin may help us reformulate our current neo-Kraepelinian nosology for the better...
  7. doi request reprint Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safety
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington St, Box 1007, Boston, MA 02111, USA
    J Clin Psychiatry 71:372-80. 2010
    ..To assess long-term effectiveness and safety of randomized antidepressant discontinuation after acute recovery from bipolar depression...
  8. ncbi request reprint The impact of the discovery of lithium on psychiatric thought and practice in the USA and Europe
    F K Goodwin
    Department of Psychiatry, George Washington University, Washington, DC 20037, USA
    Aust N Z J Psychiatry 33:S54-64. 1999
    ..In addition, the development of lithium has demonstrated the closely intertwined purposes of clinical and basic research, and the continued importance of research in the clinical setting...
  9. doi request reprint A prospective, open-label study of Aripiprazole mono- and adjunctive treatment in acute bipolar depression
    Robert T Dunn
    Psychopharmacology Research Program, Cambridge Health Alliance, Cambridge, MA, USA
    J Affect Disord 110:70-4. 2008
    ..To examine the efficacy and tolerability of aripiprazole treatment for acute bipolar depression...
  10. ncbi request reprint Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD
    Joseph F Goldberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Clin Psychiatry 70:155-62. 2009
    ..Many patients with bipolar disorder receive multi-drug treatment regimens, but the distinguishing profiles of patients who receive complex pharmacologies have not been established...
  11. ncbi request reprint Use of atypical antipsychotic agents in bipolar and schizoaffective disorders: review of the empirical literature
    S N Ghaemi
    Center on Neuroscience, Medical Progress, and Society, Department of Psychiatry, George Washington University, Washington, DC, USA
    J Clin Psychopharmacol 19:354-61. 1999
    ..If randomized or double-blind data support the open-label data reviewed here, atypical antipsychotic agents may possess an important role in the adjunctive treatment of bipolar disorder...
  12. ncbi request reprint Long-term naturalistic treatment of depressive symptoms in bipolar illness with divalproex vs. lithium in the setting of minimal antidepressant use
    S N Ghaemi
    Psychopharmacology Program, Cambridge Hospital, Consolidated Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA
    J Affect Disord 65:281-7. 2001
    ..Both agents, but particularly divalproex, demonstrated long-term antidepressant effects, with limited adjunctive standard antidepressant use...
  13. ncbi request reprint Effectiveness and safety of long-term antidepressant treatment in bipolar disorder
    S N Ghaemi
    Consolidated Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 62:565-9. 2001
    ..We sought to review research on use of antidepressants for long-term treatment of bipolar depression...
  14. ncbi request reprint Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety
    Gary S Sachs
    Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Suite 580, Boston, MA 02114, USA
    Am J Psychiatry 159:1146-54. 2002
    ..The study assessed the efficacy and safety of risperidone as an adjunctive agent to mood stabilizers in the treatment of acute mania...
  15. doi request reprint Predictors of response to ziprasidone: results from a 6-week randomized double-blind, placebo-controlled trial for acute depressive mixed state
    C U Pae
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Pharmacopsychiatry 45:152-5. 2012
    ..The present study is aimed at investigating possible predictors of response to ziprasidone in a sample of patients with mixed depressive state...
  16. ncbi request reprint Gabapentin treatment of the non-refractory bipolar spectrum: an open case series
    S N Ghaemi
    Psychopharmacology Program, Cambridge Hospital, Consolidated Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA
    J Affect Disord 65:167-71. 2001
    ..To determine if gabapentin is effective in monotherapy or add-on treatment of non-refractory bipolar disorder in open prospective treatment...
  17. ncbi request reprint Long-term outcome with divalproex in children and adolescents with bipolar disorder
    Charles A Henry
    Department of Psychiatry, Harvard Medical School, Cambridge, Massachusetts, USA
    J Child Adolesc Psychopharmacol 13:523-9. 2003
    ..To assess the outcome and safety of divalproex treatment in children and adolescents with bipolar disorder...
  18. ncbi request reprint Strategies for preventing the recurrence of bipolar disorder
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, Mass 02139, USA
    J Clin Psychiatry 65:16-23. 2004
    ..Some psychotherapies also may possess adjunctive maintenance efficacy...
  19. ncbi request reprint Antidepressants in bipolar disorder: the case for caution
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA and Harvard Medical School, Boston, MA 02139, USA
    Bipolar Disord 5:421-33. 2003
    ....
  20. ncbi request reprint The emergency treatment of depression complicated by psychosis or agitation
    R L Glick
    Department of Psychiatry, University of Michigan Health System, Ann Arbor, USA
    J Clin Psychiatry 61:43-8. 2000
    ..This article will review relevant data and make recommendations for the emergency management of psychotic and agitated depressive syndromes...
  21. ncbi request reprint The prescription of psychotropic medications for patients discharged from a psychiatric emergency service
    Carrie L Ernst
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 67:720-6. 2006
    ..We evaluated the nature and prevalence of medication prescriptions for patients discharged from an urban psychiatric emergency service and the extent to which pharmacotherapy initiation was predictive of follow-through with aftercare...
  22. ncbi request reprint "Cade's disease" and beyond: misdiagnosis, antidepressant use, and a proposed definition for bipolar spectrum disorder
    S Nassir Ghaemi
    Department of Psychiatry, Cambridge Hospital, 1493 Cambridge Street, Cambridge, MA 02139, USA
    Can J Psychiatry 47:125-34. 2002
    ..The role of antidepressants is also controversial. Our review of the evidence leads us to conclude that there should be less emphasis on using antidepressants to treat persons with this illness...
  23. ncbi request reprint Cholesterol levels in mood disorders: high or low?
    S N Ghaemi
    Harvard Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Bipolar Disord 2:60-4. 2000
    ..To assess cholesterol levels in patients with mood disorders...
  24. ncbi request reprint Pramipexole augmentation in the treatment of unipolar and bipolar depression: a retrospective chart review
    J Sporn
    Department of Psychiatry, Massachusetts General Hospital, USA
    Ann Clin Psychiatry 12:137-40. 2000
    ..To assess the effectiveness and safety of pramipexole as an adjunctive medication in refractory bipolar and unipolar depression in a naturalistic setting...
  25. ncbi request reprint Substance use disorder and other predictors of antidepressant-induced mania: a retrospective chart review
    Sumita G Manwani
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA, USA
    J Clin Psychiatry 67:1341-5. 2006
    ..To determine if substance use disorder (SUD) is a predictor of antidepressant-induced mania (ADM) in bipolar disorder, correcting for confounding factors in a regression model...
  26. ncbi request reprint Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:394-9. 2006
    ....
  27. ncbi request reprint Long-term lamotrigine plus lithium for bipolar disorder: One year outcome
    S Nassir Ghaemi
    Department of Psychiatry, School of Medicine, Emory University, GA, USA
    J Psychiatr Pract 12:300-5. 2006
    ..To obtain pilot data in an observational setting on the use of lamotrigine plus lithium in the long-term treatment of patients with bipolar disorder, 87% of whom had failed to respond to at least one previous mood stabilizer...
  28. ncbi request reprint Long-term observational comparison of risperidone and olanzapine in bipolar disorder
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Health Alliance, Cambridge, Massachusetts, USA
    Ann Clin Psychiatry 16:69-73. 2004
    ..EPS was similar, and tardive dyskinesia did not occur. Risperidone and olanzapine appeared to have similar real-world maintenance effectiveness for bipolar disorder, but differed somewhat in side effects...
  29. ncbi request reprint Antidepressant treatment in bipolar versus unipolar depression
    S Nassir Ghaemi
    Department of Psychiatry, Cambridge Hospital, MA 02139, USA
    Am J Psychiatry 161:163-5. 2004
    ..Antidepressant responses were compared in DSM-IV bipolar and unipolar depression...
  30. doi request reprint Affective temperaments in clinical practice: a validation study in mood disorders
    P A Vöhringer
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, United States
    J Affect Disord 136:577-80. 2012
    ..We sought to examine correlations between clinical validators and temperaments in clinical practice...
  31. ncbi request reprint Bipolar spectrum disorder: a pilot study
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA 02139, USA
    Psychopathology 37:222-6. 2004
    ..To assess depressive features of a proposed definition of bipolar spectrum disorder (BSD)...
  32. ncbi request reprint Galantamine treatment of cognitive impairment in bipolar disorder: four cases
    Eric Schrauwen
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA, USA
    Bipolar Disord 8:196-9. 2006
    ..To determine if galantamine is effective in the treatment of chronic cognitive impairment in bipolar disorder...
  33. ncbi request reprint Evidence-based pharmacotherapy of bipolar disorder
    S Nassir Ghaemi
    Cambridge Health Alliance, Department of Psychiatry, Cambridge, MA 02139, USA
    Int J Neuropsychopharmacol 6:303-8. 2003
    ..Further, RCTs only establish a categorical response to a research question, i.e. whether or not something happens. The frequency of an event (treatment response, side-effects) is often more accurately assessed with observational studies...
  34. ncbi request reprint Extrapyramidal side effects with atypical neuroleptics in bipolar disorder
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Emory University, 1365 Clifton Road, Building B, Suite 6100, Atlanta, GA 30322, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:209-13. 2006
    ..To examine, in a real-world clinical setting, the risk of extrapyramidal symptoms (EPS) with atypical neuroleptics in bipolar patients...
  35. ncbi request reprint Rediscovering existential psychotherapy: the contribution of Ludwig Binswanger
    S N Ghaemi
    Department of Psychiatry, Harvard Medical School, Cambridge Hospital, Cambridge, MA, USA
    Am J Psychother 55:51-64. 2001
    ..I discuss concrete clinical cases from Binswanger's work, along with a contemporary example of how to use these existential methods in psychiatric practice...
  36. ncbi request reprint Research reports on treatments for bipolar disorder: preliminary assessment of methodological quality
    F Soldani
    Department of Psychiatry, Harvard Medical School, Boston, MA 02478, USA
    Acta Psychiatr Scand 112:72-4. 2005
    ..To assess frequencies of types of publications about bipolar disorder (BD) and evaluate methodological quality of treatment studies...
  37. ncbi request reprint Existence and pluralism: the rediscovery of Karl Jaspers
    S Nassir Ghaemi
    Department of Psychiatry, Emory University, Atlanta, GA, USA
    Psychopathology 40:75-82. 2007
    ..Contemporary psychiatry has only a limited appreciation of Jaspers' work. In this paper, I attempt to describe these important concepts that can help us understand what we do in psychiatry, what we should be doing and why...
  38. doi request reprint Diagnostic guidelines for bipolar disorder: a summary of the International Society for Bipolar Disorders Diagnostic Guidelines Task Force Report
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Bipolar Disord 10:117-28. 2008
    ....
  39. ncbi request reprint Misdiagnosis of bipolar disorder in children and adolescents: a comparison with ADHD and major depressive disorder
    Jagan K Chilakamarri
    Department of Psychiatry, Emory University, Atlanta, GA, USA
    Ann Clin Psychiatry 23:25-9. 2011
    ..Controversy surrounds the frequency of underdiagnosis vs overdiagnosis of bipolar disorder (BD) in children and adolescents compared with diagnoses of attention-deficit/hyperactivity disorder (ADHD) and major depressive disorder (MDD)...
  40. ncbi request reprint Existential despair and bipolar disorder: the therapeutic alliance as a mood stabilizer
    Leston L Havens
    Harvard Medical School, Boston, MA, USA
    Am J Psychother 59:137-47. 2005
    ..It is a tall order, and one not infrequently avoided. Yet the times seem to call for a return to actually talking with manic patients, and maybe curing them with such talk. Or perhaps that is grandiose...
  41. ncbi request reprint Is insight in mania state-dependent?: A meta-analysis
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, Massachusetts 02139, USA
    J Nerv Ment Dis 192:771-5. 2004
    ..We suggest that impaired insight be considered as part of the diagnostic picture of acute mania...
  42. doi request reprint The International Society for Bipolar Disorders (ISBD) Task Force report on the nomenclature of course and outcome in bipolar disorders
    Mauricio Tohen
    Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7792, San Antonio, TX 78229, USA
    Bipolar Disord 11:453-73. 2009
    ....
  43. ncbi request reprint Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BD participants
    Claudia F Baldassano
    Bipolar Disorders Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Bipolar Disord 7:465-70. 2005
    ..To examine gender differences in a large sample of patients with bipolar illness...
  44. ncbi request reprint Side effects of atypical antipsychotics: extrapyramidal symptoms and the metabolic syndrome
    Arshia A Shirzadi
    Harvard South Shore Psychiatry Program, Brockton, MA, USA
    Harv Rev Psychiatry 14:152-64. 2006
    ..Future prospective observational cohort studies must target side effects and be designed to collect and analyze data on confounding factors...
  45. ncbi request reprint Insight in psychosis: a systematic review of treatment interventions
    Charles Henry
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA, USA
    Psychopathology 37:194-9. 2004
    ..We conclude that this literature suggests potentially useful options for clinicians, but further research is needed with better validated insight scales...

Research Grants3

  1. Treatment for Bipolar Depression: Acute & Prophylactic Efficacy with Citalopram
    NASSIR GHAEMI; Fiscal Year: 2009
    ..Especially given suggestions that some patients may markedly worsen with antidepressants, better understanding of when to use, and when not to use, antidepressants in bipolar disorder is a major public health concern. ..
  2. Treatment for Bipolar Depression: Acute & Prophylactic Efficacy with Citalopram
    NASSIR GHAEMI; Fiscal Year: 2010
    ..Especially given suggestions that some patients may markedly worsen with antidepressants, better understanding of when to use, and when not to use, antidepressants in bipolar disorder is a major public health concern. ..