Research Topics
| Roger FieldingSummaryAffiliation: Tufts University Country: USA Publications
Research Grants
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Detail Information
Publications
Evaluation of the late life disability instrument in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) studyFang Chi Hsu
Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Health Qual Life Outcomes 8:115. 2010..In this paper we examine the measurement properties of the LLDI using data from the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study...- The Lifestyle Interventions and Independence for Elders Study: design and methodsRoger A Fielding
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Gerontol A Biol Sci Med Sci 66:1226-37. 2011..A Phase 3 randomized controlled trial is needed to fill this evidence gap... 
Activity adherence and physical function in older adults with functional limitationsRoger A Fielding
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Med Sci Sports Exerc 39:1997-2004. 2007..We examined adherence to the LIFE-P PA intervention for the first 12 months of the trial...- Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopeniaRoger A Fielding
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, MA 02111, USA
J Am Med Dir Assoc 12:249-56. 2011..23 kg/m(2) in men and ≤ 5.67 kg/m(2) in women). Sarcopenia is a highly prevalent condition in older persons that leads to disability, hospitalization, and death... - Neuromuscular contributions to age-related weaknessDavid J Clark
Brain Rehabilitation Research Center, Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida, USA
J Gerontol A Biol Sci Med Sci 67:41-7. 2012..Declines in skeletal muscle mass and quality are important factors contributing to age-related weakness. Neural activation of agonist and antagonist muscles may also be important contributing factors... - Muscle performance and physical function are associated with voluntary rate of neuromuscular activation in older adultsDavid J Clark
Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
J Gerontol A Biol Sci Med Sci 66:115-21. 2011..Accordingly, this study examines the association of neuromuscular activation rate with muscle performance in persons of different age and mobility function... - Multi-step immunofluorescent analysis of vitamin D receptor loci and myosin heavy chain isoforms in human skeletal muscleLisa Ceglia
Tufts Medical Center, Boston, MA, USA
J Mol Histol 41:137-42. 2010..This method can thus be a useful approach to study potential relationships between muscle fiber subtypes and vitamin D receptor expression... - Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exerciseMichael P Corcoran
Lipid Metabolism Laboratory and the Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 85:662-77. 2007..This review summarizes the current understanding of the effects of elevated intramyocellular lipids on insulin signaling and how these effects may be altered by varying dietary fat composition and exercise... - Weighted stair climbing in mobility-limited older people: a pilot studyJonathan Bean
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
J Am Geriatr Soc 50:663-70. 2002..To evaluate weighted stair climbing exercise (SCE) as a means of increasing lower extremity muscle power in mobility-limited older people... - The 6-minute walk test in mobility-limited elders: what is being measured?Jonathan F Bean
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
J Gerontol A Biol Sci Med Sci 57:M751-6. 2002..Though commonly utilized as an outcome measure among otherwise healthy mobility-limited elders, it is not clear whether the 6mw best represents a measure of functional limitation, aerobic capacity, or both... - Muscle fiber size and function in elderly humans: a longitudinal studyWalter R Frontera
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
J Appl Physiol 105:637-42. 2008..This suggests that surviving fibers compensate to partially correct muscle size deficits in an attempt to maintain optimal force-generating capacity... - High-velocity resistance training increases skeletal muscle peak power in older womenRoger A Fielding
Human Physiology Laboratory, Department of Health Sciences, Boston University Sargent College of Health and Rehabilitation Sciences, Boston, Massachusetts 02215, USA
J Am Geriatr Soc 50:655-62. 2002..We tested the hypothesis that a high-velocity resistance-training program (HI) would increase muscle power more than a traditional low-velocity resistance-training program (LO)... - Sex differences in single muscle fiber power in older adultsLisa S Krivickas
Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, MA 02114, USA
Med Sci Sports Exerc 38:57-63. 2006..This study was conducted to determine whether differences in power at the single muscle fiber level contribute to sex differences in whole muscle power production in the elderly... - Impact of muscle power and force on gait speed in disabled older men and womenAnthony Cuoco
Human Physiology Laboratory, Department of Health Sciences, Sargent College of Health and Rehabilitation Science, Boston University, 635 Commonwealth Ave, Boston, MA 02215, USA
J Gerontol A Biol Sci Med Sci 59:1200-6. 2004..Because HGV is highly predictive of subsequent disability, future studies should evaluate the determinants of muscle power output at low external resistances... - Increased Velocity Exercise Specific to Task (InVEST) training: a pilot study exploring effects on leg power, balance, and mobility in community-dwelling older womenJonathan F Bean
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
J Am Geriatr Soc 52:799-804. 2004..To evaluate a dynamic form of weighted vest exercise suitable for home use and designed to enhance muscle power, balance, and mobility... - Contraction-mediated mTOR, p70S6k, and ERK1/2 phosphorylation in aged skeletal muscleJascha D Parkington
Department of Health Sciences, Boston University, Boston, MA 02215, USA
J Appl Physiol 97:243-8. 2004..These observations suggest that the anabolic response to a single bout of contraction is attenuated with aging and may help explain the reduced capacity for hypertrophy in aged animals... - Assessment of analytical methods used to measure changes in body composition in the elderly and recommendations for their use in phase II clinical trialsM S Lustgarten
Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
J Nutr Health Aging 15:368-75. 2011.... - Impaired voluntary neuromuscular activation limits muscle power in mobility-limited older adultsDavid J Clark
Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
J Gerontol A Biol Sci Med Sci 65:495-502. 2010.... - Age-associated decrease in contraction-induced activation of downstream targets of Akt/mTor signaling in skeletal muscleKatsuhiko Funai
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
Am J Physiol Regul Integr Comp Physiol 290:R1080-6. 2006..These observations suggest that the anabolic response to muscle stimulation is attenuated with aging and may contribute to the limited capacity of hypertrophy in aged animals... - Differential activation of mTOR signaling by contractile activity in skeletal muscleJascha D Parkington
Dept of Health Sciences, Boston Univ, 635 Commonwealth Ave, Boston, MA 02215, USA
Am J Physiol Regul Integr Comp Physiol 285:R1086-90. 2003..Fiber type-dependent mTOR phosphorylation may be a molecular basis by which some fiber types are more susceptible to contraction-induced hypertrophy... - Changes in function and disability after resistance training: does velocity matter?: a pilot studyStephen P Sayers
Human Physilogy Laboratory, Department of Health Science, Boston University, Boston, MA 02215, USA
Am J Phys Med Rehabil 82:605-13. 2003..To compare the effects of high- and low-velocity resistance training on functional performance and disability outcomes in physically limited older women... - What are the dietary protein requirements of physically active individuals? New evidence on the effects of exercise on protein utilization during post-exercise recoveryRoger A Fielding
Human Physiology Laboratory, Department of Health Sciences, Boston University, Sargent College of Health and Rehabilitation Sciences, 635 Commonwealth Avenue, Boston, MA 02215, USA
Nutr Clin Care 5:191-6. 2002..New evidence suggests that individuals engaging in strenuous activity consume a meal rich in amino acids and carbohydrate soon after the exercise bout or training session... - Effects of chronic overload on muscle hypertrophy and mTOR signaling in young adult and aged ratsAngela Chale-Rush
Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
J Gerontol A Biol Sci Med Sci 64:1232-9. 2009..009). Eukaryotic initiation factor 2Bepsilon phosphorylation was 33% and 9% higher in Y SA and O SA compared with CON (p = .04). Translational signaling in young adult and aged plantaris muscle is equally responsive to chronic overload... - Lower extremity power training in elderly subjects with mobility limitations: a randomized controlled trialKieran F Reid
Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Aging Clin Exp Res 20:337-43. 2008..This study investigated whether high-velocity high-power training (POW) improved lower extremity muscle power and quality in functionally-limited elders greater than traditional slow-velocity progressive resistance training (STR)... - High-intensity resistance training improves muscle strength, self-reported function, and disability in long-term stroke survivorsMichelle M Ouellette
Human Physiology Laboratory, Department of Health Sciences, Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, Mass 02215, USA
Stroke 35:1404-9. 2004..CONCLUSIONS: High-intensity PRT improves both paretic and nonparetic lower extremity strength after stroke, and results in reductions in functional limitations and disability... - Creatine monohydrate as a therapeutic aid in muscular dystrophyJared P Pearlman
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
Nutr Rev 64:80-8. 2006..Though the mechanisms are still unknown, creatine has been shown to decrease cytoplasmic Ca2+ levels and increase intramuscular and cerebral phosphocreatine stores, providing potential musculoskeletal and neuroprotective effects... - Muscle impairments and behavioral factors mediate functional limitations and disability following strokeNathan K Lebrasseur
Department of Health Sciences, Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, MA 02118, USA
Phys Ther 86:1342-50. 2006.... - Predictors of adherence to physical activity in the Lifestyle Interventions and Independence for Elders pilot study (LIFE-P)W Jack Rejeski
Department of Health and Exercise Science, Box 7868, Wake Forest University, Winston Salem, NC 27109, USA
Clin Interv Aging 2:485-94. 2007..A prospective design was used to examine predictors of adherence to a physical activity intervention in older adults with compromised function... - Effects of metformin and rosiglitazone in HIV-infected patients with hyperinsulinemia and elevated waist/hip ratioKathleen Mulligan
University of California at San Francisco, San Francisco General Hospital, San Francisco, California, USA
AIDS 21:47-57. 2007..To evaluate the effects of metformin and rosiglitazone, alone or in combination, on fat distribution, insulin sensitivity, and lipids in HIV-infected patients with insulin resistance and changes in fat distribution... - The lifestyle interventions and independence for elders (LIFE) pilot study: design and methodsW Jack Rejeski
Department of HES, Box 7868, Wake Forest University, Winston Salem, NC 27109, USA
Contemp Clin Trials 26:141-54. 2005..Other goals of this pilot phase include assessments of health-related quality of life and cost-effectiveness... - Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscleNathan K Lebrasseur
Myocardial Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston 02218, USA
Am J Physiol Cell Physiol 284:C1149-55. 2003..To our knowledge, this is the first demonstration of physiological regulation of NRG/ErbB signaling in any organ and implicates this pathway in the metabolic and proliferative responses of skeletal muscle to exercise... - The expression of neuregulin and erbB receptors in human skeletal muscle: effects of progressive resistance trainingNathan K Lebrasseur
Human Physiology Laboratory, Department of Health Sciences, Sargent College of Health and Rehabilitation Sciences, Boston University, Massachusetts, 02215, USA
Eur J Appl Physiol 94:371-5. 2005..Following PRT, a significant increase in erbB3 was observed. The ability to detect basal expression and alterations in response to physiologic stimuli merit further studies examining the role of this system in skeletal muscle...
Research Grants
- LOWER EXTREMITY MUSCLE POWER AND FUNCTION IN THE ELDERLYRoger Fielding; Fiscal Year: 2003..abstract_text> ..
- Activity-dependent signaling in aging skeletal muscleRoger Fielding; Fiscal Year: 2006....
- LOWER EXTREMITY MUSCLE POWER AND FUNCTION IN THE ELDERLYRoger Fielding; Fiscal Year: 2009..abstract_text> ..