Roger Fielding

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. pmc Serum glycine is associated with regional body fat and insulin resistance in functionally-limited older adults
    Michael S Lustgarten
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, Massachusetts, United States of America
    PLoS ONE 8:e84034. 2013
  2. pmc Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on Sarcopenia
    Matteo Cesari
    Gerontopôle and INSERM Unit 1027, Universite de Toulouse, Toulouse, France
    J Cachexia Sarcopenia Muscle 3:181-90. 2012
  3. pmc Role and potential mechanisms of anabolic resistance in sarcopenia
    Prashanth H Haran
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA, 02111, USA
    J Cachexia Sarcopenia Muscle 3:157-62. 2012
  4. pmc An evaluation of the reliability of muscle fiber cross-sectional area and fiber number measurements in rat skeletal muscle
    Lisa Ceglia
    Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, Washington Street, Box 268, 800, Boston, MA, 02111, USA
    Biol Proced Online 15:6. 2013
  5. pmc Efficacy of whey protein supplementation on resistance exercise-induced changes in lean mass, muscle strength, and physical function in mobility-limited older adults
    Angela Chalé
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 68:682-90. 2013
  6. pmc Evaluation of the late life disability instrument in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study
    Fang Chi Hsu
    Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Health Qual Life Outcomes 8:115. 2010
  7. ncbi request reprint Activity adherence and physical function in older adults with functional limitations
    Roger A Fielding
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Med Sci Sports Exerc 39:1997-2004. 2007
  8. pmc Neuromuscular contributions to age-related weakness
    David J Clark
    Brain Rehabilitation Research Center, Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida, USA
    J Gerontol A Biol Sci Med Sci 67:41-7. 2012
  9. pmc Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia
    Roger A Fielding
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, MA 02111, USA
    J Am Med Dir Assoc 12:249-56. 2011
  10. pmc The Lifestyle Interventions and Independence for Elders Study: design and methods
    Roger A Fielding
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 66:1226-37. 2011

Research Grants

Collaborators

Detail Information

Publications37

  1. pmc Serum glycine is associated with regional body fat and insulin resistance in functionally-limited older adults
    Michael S Lustgarten
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, Massachusetts, United States of America
    PLoS ONE 8:e84034. 2013
    ..Metabolic profiling may provide insight into biologic mechanisms related to age-related increases in regional adiposity and insulin resistance...
  2. pmc Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on Sarcopenia
    Matteo Cesari
    Gerontopôle and INSERM Unit 1027, Universite de Toulouse, Toulouse, France
    J Cachexia Sarcopenia Muscle 3:181-90. 2012
    ..However, the reasonable uncertainties (derived from exploring a novel field and the exponential acceleration of scientific progress) require the adoption of a cautious and comprehensive approach to the subject...
  3. pmc Role and potential mechanisms of anabolic resistance in sarcopenia
    Prashanth H Haran
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA, 02111, USA
    J Cachexia Sarcopenia Muscle 3:157-62. 2012
    ..Understanding the physiologic and mechanistic basis of anabolic resistance could be the key to formulating new and targeted interventions that would ease the burden currently borne by the world's aged population...
  4. pmc An evaluation of the reliability of muscle fiber cross-sectional area and fiber number measurements in rat skeletal muscle
    Lisa Ceglia
    Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, Washington Street, Box 268, 800, Boston, MA, 02111, USA
    Biol Proced Online 15:6. 2013
    ....
  5. pmc Efficacy of whey protein supplementation on resistance exercise-induced changes in lean mass, muscle strength, and physical function in mobility-limited older adults
    Angela Chalé
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 68:682-90. 2013
    ....
  6. pmc Evaluation of the late life disability instrument in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study
    Fang Chi Hsu
    Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Health Qual Life Outcomes 8:115. 2010
    ..In this paper we examine the measurement properties of the LLDI using data from the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study...
  7. ncbi request reprint Activity adherence and physical function in older adults with functional limitations
    Roger A Fielding
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Med Sci Sports Exerc 39:1997-2004. 2007
    ..We examined adherence to the LIFE-P PA intervention for the first 12 months of the trial...
  8. pmc Neuromuscular contributions to age-related weakness
    David J Clark
    Brain Rehabilitation Research Center, Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida, USA
    J Gerontol A Biol Sci Med Sci 67:41-7. 2012
    ..Declines in skeletal muscle mass and quality are important factors contributing to age-related weakness. Neural activation of agonist and antagonist muscles may also be important contributing factors...
  9. pmc Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia
    Roger A Fielding
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, MA 02111, USA
    J Am Med Dir Assoc 12:249-56. 2011
    ..23 kg/m(2) in men and ≤ 5.67 kg/m(2) in women). Sarcopenia is a highly prevalent condition in older persons that leads to disability, hospitalization, and death...
  10. pmc The Lifestyle Interventions and Independence for Elders Study: design and methods
    Roger A Fielding
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 66:1226-37. 2011
    ..A Phase 3 randomized controlled trial is needed to fill this evidence gap...
  11. pmc Muscle performance and physical function are associated with voluntary rate of neuromuscular activation in older adults
    David J Clark
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 66:115-21. 2011
    ..Accordingly, this study examines the association of neuromuscular activation rate with muscle performance in persons of different age and mobility function...
  12. pmc Multi-step immunofluorescent analysis of vitamin D receptor loci and myosin heavy chain isoforms in human skeletal muscle
    Lisa Ceglia
    Tufts Medical Center, Boston, MA, USA
    J Mol Histol 41:137-42. 2010
    ..This method can thus be a useful approach to study potential relationships between muscle fiber subtypes and vitamin D receptor expression...
  13. ncbi request reprint Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise
    Michael P Corcoran
    Lipid Metabolism Laboratory and the Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 85:662-77. 2007
    ..This review summarizes the current understanding of the effects of elevated intramyocellular lipids on insulin signaling and how these effects may be altered by varying dietary fat composition and exercise...
  14. ncbi request reprint Weighted stair climbing in mobility-limited older people: a pilot study
    Jonathan Bean
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
    J Am Geriatr Soc 50:663-70. 2002
    ..To evaluate weighted stair climbing exercise (SCE) as a means of increasing lower extremity muscle power in mobility-limited older people...
  15. ncbi request reprint The 6-minute walk test in mobility-limited elders: what is being measured?
    Jonathan F Bean
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 57:M751-6. 2002
    ..Though commonly utilized as an outcome measure among otherwise healthy mobility-limited elders, it is not clear whether the 6mw best represents a measure of functional limitation, aerobic capacity, or both...
  16. ncbi request reprint High-velocity resistance training increases skeletal muscle peak power in older women
    Roger A Fielding
    Human Physiology Laboratory, Department of Health Sciences, Boston University Sargent College of Health and Rehabilitation Sciences, Boston, Massachusetts 02215, USA
    J Am Geriatr Soc 50:655-62. 2002
    ..We tested the hypothesis that a high-velocity resistance-training program (HI) would increase muscle power more than a traditional low-velocity resistance-training program (LO)...
  17. ncbi request reprint Contraction-mediated mTOR, p70S6k, and ERK1/2 phosphorylation in aged skeletal muscle
    Jascha D Parkington
    Department of Health Sciences, Boston University, Boston, MA 02215, USA
    J Appl Physiol (1985) 97:243-8. 2004
    ..These observations suggest that the anabolic response to a single bout of contraction is attenuated with aging and may help explain the reduced capacity for hypertrophy in aged animals...
  18. ncbi request reprint Increased Velocity Exercise Specific to Task (InVEST) training: a pilot study exploring effects on leg power, balance, and mobility in community-dwelling older women
    Jonathan F Bean
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
    J Am Geriatr Soc 52:799-804. 2004
    ..To evaluate a dynamic form of weighted vest exercise suitable for home use and designed to enhance muscle power, balance, and mobility...
  19. ncbi request reprint Impact of muscle power and force on gait speed in disabled older men and women
    Anthony Cuoco
    Human Physiology Laboratory, Department of Health Sciences, Sargent College of Health and Rehabilitation Science, Boston University, 635 Commonwealth Ave, Boston, MA 02215, USA
    J Gerontol A Biol Sci Med Sci 59:1200-6. 2004
    ....
  20. pmc Muscle fiber size and function in elderly humans: a longitudinal study
    Walter R Frontera
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    J Appl Physiol (1985) 105:637-42. 2008
    ..This suggests that surviving fibers compensate to partially correct muscle size deficits in an attempt to maintain optimal force-generating capacity...
  21. ncbi request reprint Sex differences in single muscle fiber power in older adults
    Lisa S Krivickas
    Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, MA 02114, USA
    Med Sci Sports Exerc 38:57-63. 2006
    ..This study was conducted to determine whether differences in power at the single muscle fiber level contribute to sex differences in whole muscle power production in the elderly...
  22. pmc Assessment of analytical methods used to measure changes in body composition in the elderly and recommendations for their use in phase II clinical trials
    M S Lustgarten
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
    J Nutr Health Aging 15:368-75. 2011
    ....
  23. ncbi request reprint Age-associated decrease in contraction-induced activation of downstream targets of Akt/mTor signaling in skeletal muscle
    Katsuhiko Funai
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1080-6. 2006
    ..These observations suggest that the anabolic response to muscle stimulation is attenuated with aging and may contribute to the limited capacity of hypertrophy in aged animals...
  24. ncbi request reprint What are the dietary protein requirements of physically active individuals? New evidence on the effects of exercise on protein utilization during post-exercise recovery
    Roger A Fielding
    Human Physiology Laboratory, Department of Health Sciences, Boston University, Sargent College of Health and Rehabilitation Sciences, 635 Commonwealth Avenue, Boston, MA 02215, USA
    Nutr Clin Care 5:191-6. 2002
    ..New evidence suggests that individuals engaging in strenuous activity consume a meal rich in amino acids and carbohydrate soon after the exercise bout or training session...
  25. ncbi request reprint Creatine monohydrate as a therapeutic aid in muscular dystrophy
    Jared P Pearlman
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Nutr Rev 64:80-8. 2006
    ..Though the mechanisms are still unknown, creatine has been shown to decrease cytoplasmic Ca2+ levels and increase intramuscular and cerebral phosphocreatine stores, providing potential musculoskeletal and neuroprotective effects...
  26. ncbi request reprint Changes in function and disability after resistance training: does velocity matter?: a pilot study
    Stephen P Sayers
    Human Physilogy Laboratory, Department of Health Science, Boston University, Boston, MA 02215, USA
    Am J Phys Med Rehabil 82:605-13. 2003
    ..To compare the effects of high- and low-velocity resistance training on functional performance and disability outcomes in physically limited older women...
  27. ncbi request reprint Differential activation of mTOR signaling by contractile activity in skeletal muscle
    Jascha D Parkington
    Dept of Health Sciences, Boston Univ, 635 Commonwealth Ave, Boston, MA 02215, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1086-90. 2003
    ..Fiber type-dependent mTOR phosphorylation may be a molecular basis by which some fiber types are more susceptible to contraction-induced hypertrophy...
  28. ncbi request reprint Muscle impairments and behavioral factors mediate functional limitations and disability following stroke
    Nathan K Lebrasseur
    Department of Health Sciences, Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, MA 02118, USA
    Phys Ther 86:1342-50. 2006
    ....
  29. ncbi request reprint High-intensity resistance training improves muscle strength, self-reported function, and disability in long-term stroke survivors
    Michelle M Ouellette
    Human Physiology Laboratory, Department of Health Sciences, Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, Mass 02215, USA
    Stroke 35:1404-9. 2004
    ..To evaluate the efficacy of supervised high-intensity progressive resistance training (PRT) on lower extremity strength, function, and disability in older, long-term stroke survivors...
  30. pmc Impaired voluntary neuromuscular activation limits muscle power in mobility-limited older adults
    David J Clark
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 65:495-502. 2010
    ....
  31. pmc Effects of chronic overload on muscle hypertrophy and mTOR signaling in young adult and aged rats
    Angela Chale-Rush
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 64:1232-9. 2009
    ..009). Eukaryotic initiation factor 2Bepsilon phosphorylation was 33% and 9% higher in Y SA and O SA compared with CON (p = .04). Translational signaling in young adult and aged plantaris muscle is equally responsive to chronic overload...
  32. pmc Lower extremity power training in elderly subjects with mobility limitations: a randomized controlled trial
    Kieran F Reid
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Aging Clin Exp Res 20:337-43. 2008
    ..This study investigated whether high-velocity high-power training (POW) improved lower extremity muscle power and quality in functionally-limited elders greater than traditional slow-velocity progressive resistance training (STR)...
  33. ncbi request reprint Effects of metformin and rosiglitazone in HIV-infected patients with hyperinsulinemia and elevated waist/hip ratio
    Kathleen Mulligan
    University of California at San Francisco, San Francisco General Hospital, San Francisco, California, USA
    AIDS 21:47-57. 2007
    ..To evaluate the effects of metformin and rosiglitazone, alone or in combination, on fat distribution, insulin sensitivity, and lipids in HIV-infected patients with insulin resistance and changes in fat distribution...
  34. ncbi request reprint The expression of neuregulin and erbB receptors in human skeletal muscle: effects of progressive resistance training
    Nathan K Lebrasseur
    Human Physiology Laboratory, Department of Health Sciences, Sargent College of Health and Rehabilitation Sciences, Boston University, Massachusetts, 02215, USA
    Eur J Appl Physiol 94:371-5. 2005
    ..Following PRT, a significant increase in erbB3 was observed. The ability to detect basal expression and alterations in response to physiologic stimuli merit further studies examining the role of this system in skeletal muscle...
  35. ncbi request reprint Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle
    Nathan K Lebrasseur
    Myocardial Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston 02218, USA
    Am J Physiol Cell Physiol 284:C1149-55. 2003
    ..To our knowledge, this is the first demonstration of physiological regulation of NRG/ErbB signaling in any organ and implicates this pathway in the metabolic and proliferative responses of skeletal muscle to exercise...
  36. ncbi request reprint The lifestyle interventions and independence for elders (LIFE) pilot study: design and methods
    W Jack Rejeski
    Department of HES, Box 7868, Wake Forest University, Winston Salem, NC 27109, USA
    Contemp Clin Trials 26:141-54. 2005
    ..Other goals of this pilot phase include assessments of health-related quality of life and cost-effectiveness...
  37. pmc Predictors of adherence to physical activity in the Lifestyle Interventions and Independence for Elders pilot study (LIFE-P)
    W Jack Rejeski
    Department of Health and Exercise Science, Box 7868, Wake Forest University, Winston Salem, NC 27109, USA
    Clin Interv Aging 2:485-94. 2007
    ..A prospective design was used to examine predictors of adherence to a physical activity intervention in older adults with compromised function...

Research Grants9

  1. LOWER EXTREMITY MUSCLE POWER AND FUNCTION IN THE ELDERLY
    Roger Fielding; Fiscal Year: 2003
    ..abstract_text> ..
  2. Activity-dependent signaling in aging skeletal muscle
    Roger Fielding; Fiscal Year: 2006
    ....
  3. LOWER EXTREMITY MUSCLE POWER AND FUNCTION IN THE ELDERLY
    Roger Fielding; Fiscal Year: 2009
    ..abstract_text> ..