Sergio Fantini

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with oxygenation images
    Erica Heffer
    Tufts University, Department of Biomedical Engineering, Bioengineering Center, 4 Colby Street, Medford, Massachusetts 02155, USA
    J Biomed Opt 9:1152-60. 2004
  2. ncbi request reprint Spatial and spectral information in optical mammography
    Sergio Fantini
    Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Technol Cancer Res Treat 4:471-82. 2005
  3. pmc Dynamic model for the tissue concentration and oxygen saturation of hemoglobin in relation to blood volume, flow velocity, and oxygen consumption: Implications for functional neuroimaging and coherent hemodynamics spectroscopy (CHS)
    Sergio Fantini
    Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA Electronic address
    Neuroimage 85:202-21. 2014
  4. pmc Near-infrared optical mammography for breast cancer detection with intrinsic contrast
    Sergio Fantini
    Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
    Ann Biomed Eng 40:398-407. 2012
  5. doi request reprint Biomedical engineering continues to make the future
    Sergio Fantini
    Department of Biomedical Engineering, Tufts University, USA
    IEEE Pulse 2:70-3. 2011
  6. ncbi request reprint Perturbation theory for the diffusion equation by use of the moments of the generalized temporal point-spread function. II. Continuous-wave results
    Angelo Sassaroli
    Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
    J Opt Soc Am A Opt Image Sci Vis 23:2119-31. 2006
  7. pmc Reduced speed of microvascular blood flow in hemodialysis patients versus healthy controls: a coherent hemodynamics spectroscopy study
    Michele L Pierro
    Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155
    J Biomed Opt 19:026005. 2014
  8. pmc Validation of a novel hemodynamic model for coherent hemodynamics spectroscopy (CHS) and functional brain studies with fNIRS and fMRI
    Michele L Pierro
    Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA Electronic address
    Neuroimage 85:222-33. 2014
  9. ncbi request reprint Higher-order perturbation theory for the diffusion equation in heterogeneous media: application to layered and slab geometries
    Angelo Sassaroli
    Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts, USA
    Appl Opt 48:D62-73. 2009
  10. pmc Perturbation theory for the diffusion equation by use of the moments of the generalized temporal point-spread function. III. Frequency-domain and time-domain results
    Angelo Sassaroli
    Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
    J Opt Soc Am A Opt Image Sci Vis 27:1723-42. 2010

Research Grants

  1. Near-infrared oximetry of breast tumors
    Sergio Fantini; Fiscal Year: 2007

Detail Information

Publications39

  1. ncbi request reprint Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with oxygenation images
    Erica Heffer
    Tufts University, Department of Biomedical Engineering, Bioengineering Center, 4 Colby Street, Medford, Massachusetts 02155, USA
    J Biomed Opt 9:1152-60. 2004
    ..Oxygenation information may help discriminate benign from malignant breast lesions, thereby effectively complementing single-wavelength optical mammograms that display optically dense regions within the breast with high sensitivity...
  2. ncbi request reprint Spatial and spectral information in optical mammography
    Sergio Fantini
    Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Technol Cancer Res Treat 4:471-82. 2005
    ..The optimization of the spatial and spectral information in optical mammography has the potential to create a role for this imaging modality in the detection and monitoring of breast cancer...
  3. pmc Dynamic model for the tissue concentration and oxygen saturation of hemoglobin in relation to blood volume, flow velocity, and oxygen consumption: Implications for functional neuroimaging and coherent hemodynamics spectroscopy (CHS)
    Sergio Fantini
    Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA Electronic address
    Neuroimage 85:202-21. 2014
    ....
  4. pmc Near-infrared optical mammography for breast cancer detection with intrinsic contrast
    Sergio Fantini
    Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
    Ann Biomed Eng 40:398-407. 2012
    ..Intrinsic sources of optical contrast associated with breast cancer can also be used to monitor individual response to neoadjuvant therapy...
  5. doi request reprint Biomedical engineering continues to make the future
    Sergio Fantini
    Department of Biomedical Engineering, Tufts University, USA
    IEEE Pulse 2:70-3. 2011
    ..The depth of the design projects, research experience, coursework, study abroad options, and internships all convenes to establish a solid foundation for our students as they embark on their career paths...
  6. ncbi request reprint Perturbation theory for the diffusion equation by use of the moments of the generalized temporal point-spread function. II. Continuous-wave results
    Angelo Sassaroli
    Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
    J Opt Soc Am A Opt Image Sci Vis 23:2119-31. 2006
    ..We also provide formulas for the calculation of the moments up to the fourth order for which it is clear how lower-order moments can be used for the calculation of higher-order moments...
  7. pmc Reduced speed of microvascular blood flow in hemodialysis patients versus healthy controls: a coherent hemodynamics spectroscopy study
    Michele L Pierro
    Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155
    J Biomed Opt 19:026005. 2014
    ....
  8. pmc Validation of a novel hemodynamic model for coherent hemodynamics spectroscopy (CHS) and functional brain studies with fNIRS and fMRI
    Michele L Pierro
    Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA Electronic address
    Neuroimage 85:222-33. 2014
    ..This comparison shows an excellent agreement between the model predictions and the reported fNIRS and BOLD fMRI signals. This new hemodynamic model provides a valuable tool for brain studies with hemodynamic-based techniques. ..
  9. ncbi request reprint Higher-order perturbation theory for the diffusion equation in heterogeneous media: application to layered and slab geometries
    Angelo Sassaroli
    Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts, USA
    Appl Opt 48:D62-73. 2009
    ..Finally, we study the possibility of using the proposed method for calculating the effect of a colocalized scattering and absorbing perturbation...
  10. pmc Perturbation theory for the diffusion equation by use of the moments of the generalized temporal point-spread function. III. Frequency-domain and time-domain results
    Angelo Sassaroli
    Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
    J Opt Soc Am A Opt Image Sci Vis 27:1723-42. 2010
    ..06 mm(-1). The proposed method is an effective fast forward problem solver: all the time-domain results presented in this work were obtained with a computational time of less than about 15 s with a Pentium IV 1.66 GHz personal computer...
  11. ncbi request reprint Near-infrared spectral imaging of the female breast for quantitative oximetry in optical mammography
    Yang Yu
    Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
    Appl Opt 48:D225-35. 2009
    ....
  12. ncbi request reprint Bilateral near-infrared monitoring of the cerebral concentration and oxygen-saturation of hemoglobin during right unilateral electro-convulsive therapy
    Francesco Fabbri
    Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Brain Res 992:193-204. 2003
    ..These findings provide indications about the cerebral hemodynamic/metabolic mechanisms associated with ECT, and may lead to useful parameters to predict the individual clinical outcome of ECT...
  13. pmc Optical characterization of two-layered turbid media for non-invasive, absolute oximetry in cerebral and extracerebral tissue
    Bertan Hallacoglu
    Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA
    PLoS ONE 8:e64095. 2013
    ....
  14. ncbi request reprint Spatially weighted BOLD signal for comparison of functional magnetic resonance imaging and near-infrared imaging of the brain
    Angelo Sassaroli
    Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, and Brain Imaging Center, McLean Hospital, Belmont 02478, USA
    Neuroimage 33:505-14. 2006
    ..These findings reinforce the idea that fMRI and NIRS are sensitive to similar underlying hemodynamic changes, and indicate that the proposed weighted BOLD signal is needed for a quantitative comparison of BOLD and NIRS signals...
  15. ncbi request reprint Spatial second-derivative image processing: an application to optical mammography to enhance the detection of breast tumors
    Vivian E Pera
    Tufts University, Bioengineering Center, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, USA
    J Biomed Opt 8:517-24. 2003
    ....
  16. pmc Depth discrimination in diffuse optical transmission imaging by planar scanning off-axis fibers: initial applications to optical mammography
    Jana M Kainerstorfer
    Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, United States of America
    PLoS ONE 8:e58510. 2013
    ..This depth discrimination method can enhance the spatial information content of 2D projection images of the breast by assessing the depth of detected structures, and by allowing for 3D localization of breast tumors...
  17. pmc Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopy
    Bertan Hallacoglu
    Tufts University, Department of Biomedical Engineering, 4 Colby St, Medford, MA 02155, USA
    J Biomed Opt 17:081406-1. 2012
    ....
  18. pmc Cerebral perfusion and oxygenation are impaired by folate deficiency in rat: absolute measurements with noninvasive near-infrared spectroscopy
    Bertan Hallacoglu
    Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA
    J Cereb Blood Flow Metab 31:1482-92. 2011
    ..Vasomotor reactivity in response to hypercapnia was also impaired in FD rats. Our results implicate microvascular abnormality and diminished oxygen delivery as a mechanism of cognitive impairment...
  19. ncbi request reprint Two-dimensional phased arrays of sources and detectors for depth discrimination in diffuse optical imaging
    Ning Liu
    Tufts University, Department of Biomedical Engineering, Bioengineering Center, 4 Colby Street, Medford, Massachusetts 02155, USA
    J Biomed Opt 10:051801. 2005
    ..We find that the proposed phased-array method is able to separate cylinders at different depths, thus showing cross-sectioning capabilities...
  20. ncbi request reprint Comment on the modified Beer-Lambert law for scattering media
    Angelo Sassaroli
    Department of Biomedical Engineering, Bioengineering Center, Tufts University, Medford, MA 02155, USA
    Phys Med Biol 49:N255-7. 2004
    ..Here we propose a notation for the modified Beer-Lambert law that keeps the typical form commonly found in the literature without introducing any incorrect assumptions...
  21. ncbi request reprint Mathematical model for the hemodynamic response to venous occlusion measured with near-infrared spectroscopy in the human forearm
    Toi Van Vo
    Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
    IEEE Trans Biomed Eng 54:573-84. 2007
    ..These results indicate that this mathematical model can be a valuable analytical tool to characterize, optimize, and further develop diagnostic measurement schemes that use venous occlusion approaches...
  22. ncbi request reprint Quantitative oximetry of breast tumors: a near-infrared method that identifies two optimal wavelengths for each tumor
    Erica L Heffer
    Department of Electrical Engineering and Computer Science, Bioengineering Center, Tufts University, Medford, Massachusetts 02155, USA
    Appl Opt 41:3827-39. 2002
    ..We have found that our optical method can provide accurate and quantitative measurements of the oxygenation of embedded lesions without requiring knowledge of their size, shape, and depth...
  23. pmc Phase-amplitude investigation of spontaneous low-frequency oscillations of cerebral hemodynamics with near-infrared spectroscopy: a sleep study in human subjects
    Michele L Pierro
    Department of Biomedical Engineering, Tufts University, Medford, MA, USA
    Neuroimage 63:1571-84. 2012
    ..These results show the potential of phase-amplitude analysis of [Hb] and [HbO] oscillations measured by NIRS in the investigation of hemodynamics associated with cerebral physiology, activation, and pathological conditions...
  24. ncbi request reprint Optical measurements of absorption changes in two-layered diffusive media
    Francesco Fabbri
    Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Phys Med Biol 49:1183-201. 2004
    ....
  25. ncbi request reprint Three-element phased-array approach to diffuse optical imaging based on postprocessing of continuous-wave data
    Ning Liu
    Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
    Opt Lett 30:281-3. 2005
    ..We find that the proposed phased-array approach is able to resolve two cylinders with side-to-side separation of 10 mm that are not resolved by the intensity associated with a single light source...
  26. doi request reprint Practical steps for applying a new dynamic model to near-infrared spectroscopy measurements of hemodynamic oscillations and transient changes: implications for cerebrovascular and functional brain studies
    Jana M Kainerstorfer
    Department of Biomedical Engineering, Tufts University, 4 Colby St, Medford, MA 02155 Electronic address
    Acad Radiol 21:185-96. 2014
    ..Such a practical implementation of a quantitative hemodynamic model is an important step toward the clinical translation of NIRS...
  27. ncbi request reprint Perturbation theory for the diffusion equation by use of the moments of the generalized temporal point-spread function. I. Theory
    Angelo Sassaroli
    Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
    J Opt Soc Am A Opt Image Sci Vis 23:2105-18. 2006
    ..In a companion paper [J. Opt. Soc. Am. A23, 2119 (2006)] we discuss the conditions of applicability of the theory in practical cases found in diffuse optical imaging of biological tissues...
  28. doi request reprint Noninvasive assessment of testicular torsion in rabbits using frequency-domain near-infrared spectroscopy: prospects for pediatric urology
    Bertan Hallacoglu
    Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, USA
    J Biomed Opt 14:054027. 2009
    ....
  29. ncbi request reprint Fast optical signals in the peripheral nervous system
    Yunjie Tong
    Tufts University, Department of Biomedical Engineering, Medford, Massachusetts 02155, USA
    J Biomed Opt 11:044014. 2006
    ..Our findings support the hypothesis that the peripheral nervous system undergoes neurovascular coupling, even though more data is needed to prove such hypothesis...
  30. ncbi request reprint A haemodynamic model for the physiological interpretation of in vivo measurements of the concentration and oxygen saturation of haemoglobin
    Sergio Fantini
    Bioengineering Center, Department of Electrical Engineering and Computer Science, Tufts University, Medford, MA 02155 USA
    Phys Med Biol 47:N249-57. 2002
    ....
  31. pmc Near-infrared spiroximetry: noninvasive measurements of venous saturation in piglets and human subjects
    Maria Angela Franceschini
    Bioengineering Center, Department of Electrical Engineering and Computer Science Tufts University, Medford, Massachusetts 02155 6013, USA
    J Appl Physiol (1985) 92:372-84. 2002
    ..Finally, in a preliminary test involving muscle exercise, Sv(O(2))-NIRS(resp) showed an expected postexercise decrease from the initial baseline value and a subsequent recovery to baseline...
  32. ncbi request reprint Paired-wavelength spectral approach to measuring the relative concentrations of two localized chromophores in turbid media: an experimental study
    Ning Liu
    Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, USA
    J Biomed Opt 12:051602. 2007
    ....
  33. ncbi request reprint Characterization of spatial and temporal variations in the optical properties of tissuelike media with diffuse reflectance imaging
    Francesco Fabbri
    Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
    Appl Opt 42:3063-72. 2003
    ..In the case of media with optical properties similar to those of tissue in the near infrared, we found that the changes mu(a)/mu(s)' should occur over a volume approximately 2 mm deep and 4 mm x 4 mm wide to apply this expression...
  34. pmc Implantable, multifunctional, bioresorbable optics
    Hu Tao
    Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
    Proc Natl Acad Sci U S A 109:19584-9. 2012
    ....
  35. pmc Parametric estimation of 3D tubular structures for diffuse optical tomography
    Fridrik Larusson
    Department of Electrical and Computer Engineering, Tufts University, Medford, MA 02155, USA Currently with Intellectual Ventures, Global Good, Bellevue, WA 98122, USA
    Biomed Opt Express 4:271-86. 2013
    ..We report on simulated and experimental reconstructions using realistic optical contrasts where our method provides a more accurate estimate compared to an unregularized approach and a pixel based reconstruction...
  36. pmc Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging
    Maria Angela Franceschini
    NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Psychophysiology 40:548-60. 2003
    ..Our findings based on optical imaging are in agreement with results in the literature obtained with positron emission tomography and functional magnetic resonance imaging...
  37. ncbi request reprint Spatial distribution of vastus lateralis blood flow and oxyhemoglobin saturation measured at the end of isometric quadriceps contraction by multichannel near-infrared spectroscopy
    Valentina Quaresima
    University of L Aquila, Department of Biomedical Sciences and Technologies, 67100 L Aquila, Italy
    J Biomed Opt 9:413-20. 2004
    ..These data confirm that frequency-domain tissue oximeters are noninvasive, powerful tools to investigate the spatial and temporal features of muscle blood flow and oxygenation, with potential applications in areas of pathophysiology...
  38. ncbi request reprint Absolute frequency-domain pulse oximetry of the brain: methodology and measurements
    Martin Wolf
    Clinic for Neonatology, University Hospital, Frauenklinikstr 10, 8091 Zurich, Switzerland
    Adv Exp Med Biol 530:61-73. 2003
    ..fdSaO2 and poSaO2 agree very well (mean difference: -1.2 +/- 2.6%). Changes in SO2 were systematically smaller than in fdSaO2 or poSaO2 probably due to autoregulation. The measurements with 4 and 8 wavelengths had comparable quality...
  39. ncbi request reprint Workshop on imaging science development for cancer prevention and preemption
    Gary J Kelloff
    NIH NCI DCTD, Cancer Imaging Program, Bethesda, MD, USA
    Cancer Biomark 3:1-33. 2007
    ..Imaging devices, alone or in combination with anticancer drugs, may also provide novel interventions to treat or prevent precancer...

Research Grants2

  1. Near-infrared oximetry of breast tumors
    Sergio Fantini; Fiscal Year: 2007
    ..Our proposed approach to optical mammography has the potential to improve both the specificity and the sensitivity of current optical instruments, and it may open new opportunities in the area of breast cancer detection. ..