Research Topics
| Sergio FantiniSummaryAffiliation: Tufts University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with oxygenation imagesErica Heffer
Tufts University, Department of Biomedical Engineering, Bioengineering Center, 4 Colby Street, Medford, Massachusetts 02155, USA
J Biomed Opt 9:1152-60. 2004..Oxygenation information may help discriminate benign from malignant breast lesions, thereby effectively complementing single-wavelength optical mammograms that display optically dense regions within the breast with high sensitivity...- Spatial and spectral information in optical mammographySergio Fantini
Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
Technol Cancer Res Treat 4:471-82. 2005..The optimization of the spatial and spectral information in optical mammography has the potential to create a role for this imaging modality in the detection and monitoring of breast cancer... 
Near-infrared optical mammography for breast cancer detection with intrinsic contrastSergio Fantini
Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
Ann Biomed Eng 40:398-407. 2012..Intrinsic sources of optical contrast associated with breast cancer can also be used to monitor individual response to neoadjuvant therapy...- Biomedical engineering continues to make the futureSergio Fantini
Department of Biomedical Engineering, Tufts University, USA
IEEE Pulse 2:70-3. 2011..The depth of the design projects, research experience, coursework, study abroad options, and internships all convenes to establish a solid foundation for our students as they embark on their career paths... - Perturbation theory for the diffusion equation by use of the moments of the generalized temporal point-spread function. II. Continuous-wave resultsAngelo Sassaroli
Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
J Opt Soc Am A Opt Image Sci Vis 23:2119-31. 2006..We also provide formulas for the calculation of the moments up to the fourth order for which it is clear how lower-order moments can be used for the calculation of higher-order moments... - Near-infrared spectral imaging of the female breast for quantitative oximetry in optical mammographyYang Yu
Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
Appl Opt 48:D225-35. 2009.... - Higher-order perturbation theory for the diffusion equation in heterogeneous media: application to layered and slab geometriesAngelo Sassaroli
Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts, USA
Appl Opt 48:D62-73. 2009..Finally, we study the possibility of using the proposed method for calculating the effect of a colocalized scattering and absorbing perturbation... 
Perturbation theory for the diffusion equation by use of the moments of the generalized temporal point-spread function. III. Frequency-domain and time-domain resultsAngelo Sassaroli
Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
J Opt Soc Am A Opt Image Sci Vis 27:1723-42. 2010..06 mm(-1). The proposed method is an effective fast forward problem solver: all the time-domain results presented in this work were obtained with a computational time of less than about 15 s with a Pentium IV 1.66 GHz personal computer...- Spatially weighted BOLD signal for comparison of functional magnetic resonance imaging and near-infrared imaging of the brainAngelo Sassaroli
Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, and Brain Imaging Center, McLean Hospital, Belmont 02478, USA
Neuroimage 33:505-14. 2006..These findings reinforce the idea that fMRI and NIRS are sensitive to similar underlying hemodynamic changes, and indicate that the proposed weighted BOLD signal is needed for a quantitative comparison of BOLD and NIRS signals... - Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopyBertan Hallacoglu
Tufts University, Department of Biomedical Engineering, 4 Colby St, Medford, MA 02155, USA
J Biomed Opt 17:081406-1. 2012.... - Comment on the modified Beer-Lambert law for scattering mediaAngelo Sassaroli
Department of Biomedical Engineering, Bioengineering Center, Tufts University, Medford, MA 02155, USA
Phys Med Biol 49:N255-7. 2004..Here we propose a notation for the modified Beer-Lambert law that keeps the typical form commonly found in the literature without introducing any incorrect assumptions... - Cerebral perfusion and oxygenation are impaired by folate deficiency in rat: absolute measurements with noninvasive near-infrared spectroscopyBertan Hallacoglu
Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA
J Cereb Blood Flow Metab 31:1482-92. 2011..Vasomotor reactivity in response to hypercapnia was also impaired in FD rats. Our results implicate microvascular abnormality and diminished oxygen delivery as a mechanism of cognitive impairment... - Two-dimensional phased arrays of sources and detectors for depth discrimination in diffuse optical imagingNing Liu
Tufts University, Department of Biomedical Engineering, Bioengineering Center, 4 Colby Street, Medford, Massachusetts 02155, USA
J Biomed Opt 10:051801. 2005..We find that the proposed phased-array method is able to separate cylinders at different depths, thus showing cross-sectioning capabilities... - Optical measurements of absorption changes in two-layered diffusive mediaFrancesco Fabbri
Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, MA 02155, USA
Phys Med Biol 49:1183-201. 2004.... - Spatial second-derivative image processing: an application to optical mammography to enhance the detection of breast tumorsVivian E Pera
Tufts University, Bioengineering Center, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, USA
J Biomed Opt 8:517-24. 2003.... - Three-element phased-array approach to diffuse optical imaging based on postprocessing of continuous-wave dataNing Liu
Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
Opt Lett 30:281-3. 2005..We find that the proposed phased-array approach is able to resolve two cylinders with side-to-side separation of 10 mm that are not resolved by the intensity associated with a single light source... - Depth discrimination in diffuse optical transmission imaging by planar scanning off-axis fibers: initial applications to optical mammographyJana M Kainerstorfer
Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, United States of America
PLoS ONE 8:e58510. 2013..This depth discrimination method can enhance the spatial information content of 2D projection images of the breast by assessing the depth of detected structures, and by allowing for 3D localization of breast tumors... - Perturbation theory for the diffusion equation by use of the moments of the generalized temporal point-spread function. I. TheoryAngelo Sassaroli
Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
J Opt Soc Am A Opt Image Sci Vis 23:2105-18. 2006..In a companion paper [J. Opt. Soc. Am. A23, 2119 (2006)] we discuss the conditions of applicability of the theory in practical cases found in diffuse optical imaging of biological tissues... - Fast optical signals in the peripheral nervous systemYunjie Tong
Tufts University, Department of Biomedical Engineering, Medford, Massachusetts 02155, USA
J Biomed Opt 11:044014. 2006..Our findings support the hypothesis that the peripheral nervous system undergoes neurovascular coupling, even though more data is needed to prove such hypothesis... - Mathematical model for the hemodynamic response to venous occlusion measured with near-infrared spectroscopy in the human forearmToi Van Vo
Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
IEEE Trans Biomed Eng 54:573-84. 2007..These results indicate that this mathematical model can be a valuable analytical tool to characterize, optimize, and further develop diagnostic measurement schemes that use venous occlusion approaches... - Noninvasive assessment of testicular torsion in rabbits using frequency-domain near-infrared spectroscopy: prospects for pediatric urologyBertan Hallacoglu
Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, USA
J Biomed Opt 14:054027. 2009.... - Bilateral near-infrared monitoring of the cerebral concentration and oxygen-saturation of hemoglobin during right unilateral electro-convulsive therapyFrancesco Fabbri
Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, MA 02155, USA
Brain Res 992:193-204. 2003..These findings provide indications about the cerebral hemodynamic/metabolic mechanisms associated with ECT, and may lead to useful parameters to predict the individual clinical outcome of ECT... - Near-infrared spiroximetry: noninvasive measurements of venous saturation in piglets and human subjectsMaria Angela Franceschini
Bioengineering Center, Department of Electrical Engineering and Computer Science Tufts University, Medford, Massachusetts 02155 6013, USA
J Appl Physiol 92:372-84. 2002..Finally, in a preliminary test involving muscle exercise, Sv(O(2))-NIRS(resp) showed an expected postexercise decrease from the initial baseline value and a subsequent recovery to baseline... - Phase-amplitude investigation of spontaneous low-frequency oscillations of cerebral hemodynamics with near-infrared spectroscopy: a sleep study in human subjectsMichele L Pierro
Department of Biomedical Engineering, Tufts University, Medford, MA, USA
Neuroimage 63:1571-84. 2012..These results show the potential of phase-amplitude analysis of [Hb] and [HbO] oscillations measured by NIRS in the investigation of hemodynamics associated with cerebral physiology, activation, and pathological conditions... - Paired-wavelength spectral approach to measuring the relative concentrations of two localized chromophores in turbid media: an experimental studyNing Liu
Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, USA
J Biomed Opt 12:051602. 2007.... - Implantable, multifunctional, bioresorbable opticsHu Tao
Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
Proc Natl Acad Sci U S A 109:19584-9. 2012.... - A haemodynamic model for the physiological interpretation of in vivo measurements of the concentration and oxygen saturation of haemoglobinSergio Fantini
Bioengineering Center, Department of Electrical Engineering and Computer Science, Tufts University, Medford, MA 02155. USA
Phys Med Biol 47:N249-57. 2002.... - Quantitative oximetry of breast tumors: a near-infrared method that identifies two optimal wavelengths for each tumorErica L Heffer
Department of Electrical Engineering and Computer Science, Bioengineering Center, Tufts University, Medford, Massachusetts 02155, USA
Appl Opt 41:3827-39. 2002..We have found that our optical method can provide accurate and quantitative measurements of the oxygenation of embedded lesions without requiring knowledge of their size, shape, and depth... - Parametric estimation of 3D tubular structures for diffuse optical tomographyFridrik Larusson
Department of Electrical and Computer Engineering, Tufts University, Medford, MA 02155, USA Currently with Intellectual Ventures, Global Good, Bellevue, WA 98122, USA
Biomed Opt Express 4:271-86. 2013..We report on simulated and experimental reconstructions using realistic optical contrasts where our method provides a more accurate estimate compared to an unregularized approach and a pixel based reconstruction... - Characterization of spatial and temporal variations in the optical properties of tissuelike media with diffuse reflectance imagingFrancesco Fabbri
Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
Appl Opt 42:3063-72. 2003..In the case of media with optical properties similar to those of tissue in the near infrared, we found that the changes mu(a)/mu(s)' should occur over a volume approximately 2 mm deep and 4 mm x 4 mm wide to apply this expression... - Spatial distribution of vastus lateralis blood flow and oxyhemoglobin saturation measured at the end of isometric quadriceps contraction by multichannel near-infrared spectroscopyValentina Quaresima
University of L Aquila, Department of Biomedical Sciences and Technologies, 67100 L Aquila, Italy
J Biomed Opt 9:413-20. 2004..These data confirm that frequency-domain tissue oximeters are noninvasive, powerful tools to investigate the spatial and temporal features of muscle blood flow and oxygenation, with potential applications in areas of pathophysiology... - Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imagingMaria Angela Franceschini
NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Psychophysiology 40:548-60. 2003..Our findings based on optical imaging are in agreement with results in the literature obtained with positron emission tomography and functional magnetic resonance imaging... - Absolute frequency-domain pulse oximetry of the brain: methodology and measurementsMartin Wolf
Clinic for Neonatology, University Hospital, Frauenklinikstr 10, 8091 Zurich, Switzerland
Adv Exp Med Biol 530:61-73. 2003..fdSaO2 and poSaO2 agree very well (mean difference: -1.2 +/- 2.6%). Changes in SO2 were systematically smaller than in fdSaO2 or poSaO2 probably due to autoregulation. The measurements with 4 and 8 wavelengths had comparable quality... - Workshop on imaging science development for cancer prevention and preemptionGary J Kelloff
NIH NCI DCTD, Cancer Imaging Program, Bethesda, MD, USA
Cancer Biomark 3:1-33. 2007..Imaging devices, alone or in combination with anticancer drugs, may also provide novel interventions to treat or prevent precancer...
Research Grants
- Near-infrared oximetry of breast tumorsSergio Fantini; Fiscal Year: 2007..Our proposed approach to optical mammography has the potential to improve both the specificity and the sensitivity of current optical instruments, and it may open new opportunities in the area of breast cancer detection. ..