JAMES DICE

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi Chaperone-mediated autophagy
    J Fred Dice
    Department of Cellular and Molecular Physiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Autophagy 3:295-9. 2007
  2. ncbi Mechanisms of chaperone-mediated autophagy
    Amy E Majeski
    Department of Physiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Int J Biochem Cell Biol 36:2435-44. 2004
  3. ncbi Ketone bodies stimulate chaperone-mediated autophagy
    Patrick F Finn
    Department of Molecular and Cellular Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 280:25864-70. 2005
  4. ncbi Effects of small molecules on chaperone-mediated autophagy
    Patrick F Finn
    Department of Cellular and Molecular Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Autophagy 1:141-5. 2005
  5. ncbi Proteolytic and lipolytic responses to starvation
    Patrick F Finn
    Department of Molecular and Cellular Physiology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Nutrition 22:830-44. 2006
  6. ncbi Chaperone-mediated autophagy is defective in mucolipidosis type IV
    Bhuvarahamurthy Venugopal
    Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Cell Physiol 219:344-53. 2009

Research Grants

  1. PROTEIN DEGRADATION IN AGING HUMAN FIBROBLASTS
    JAMES DICE; Fiscal Year: 2005

Collaborators

  • Patrick F Finn
  • Amy E Majeski
  • Bhuvarahamurthy Venugopal
  • Janice M LaPlante
  • Cyntia Curcio-Morelli
  • Susan A Slaugenhaupt
  • John C Kennedy
  • Nicholas T Mesires

Detail Information

Publications6

  1. ncbi Chaperone-mediated autophagy
    J Fred Dice
    Department of Cellular and Molecular Physiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Autophagy 3:295-9. 2007
    ..These findings reveal a rich complexity of mechanisms to control CMA activity...
  2. ncbi Mechanisms of chaperone-mediated autophagy
    Amy E Majeski
    Department of Physiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Int J Biochem Cell Biol 36:2435-44. 2004
    ..The exact roles of this lysosomal chaperone remain to be defined. The mechanisms of chaperone-mediated autophagy are similar to mechanisms of protein import into mitochondria, chloroplasts, and the endoplasmic reticulum...
  3. ncbi Ketone bodies stimulate chaperone-mediated autophagy
    Patrick F Finn
    Department of Molecular and Cellular Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 280:25864-70. 2005
    ..The induction of CMA by ketone bodies may provide an important physiological mechanism for the activation of CMA during prolonged starvation...
  4. ncbi Effects of small molecules on chaperone-mediated autophagy
    Patrick F Finn
    Department of Cellular and Molecular Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Autophagy 1:141-5. 2005
    ..Finally we demonstrate that the glucose-6-phophate dehydrogenase inhibitor, 6-aminonicotinamide, and heat shock protein of 90 kilodaltons inhibitor, geldanamycin, have the ability to activate CMA...
  5. ncbi Proteolytic and lipolytic responses to starvation
    Patrick F Finn
    Department of Molecular and Cellular Physiology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Nutrition 22:830-44. 2006
    ..Tissues that cannot use ketone bodies for energy respond to these small molecules by activating chaperone-mediated autophagy. This is one form of interaction between proteolytic and lipolytic responses to starvation...
  6. ncbi Chaperone-mediated autophagy is defective in mucolipidosis type IV
    Bhuvarahamurthy Venugopal
    Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Cell Physiol 219:344-53. 2009
    ..It is also possible that TRPML1 channel activity may be required for CMA. Understanding the role of TRPML1 in CMA will undoubtedly help to characterize the pathogenesis of MLIV...

Research Grants10

  1. PROTEIN DEGRADATION IN AGING HUMAN FIBROBLASTS
    JAMES DICE; Fiscal Year: 2005
    ..These studies will include correction of the receptor levels in lysosomes of aged cells and analysis of the effects of restoring this protein degradation pathway on levels of aberrant proteins in senescent cells. ..