B Dawson-Hughes

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. pmc An evaluation of the reliability of muscle fiber cross-sectional area and fiber number measurements in rat skeletal muscle
    Lisa Ceglia
    Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, Washington Street, Box 268, 800, Boston, MA, 02111, USA
    Biol Proced Online 15:6. 2013
  2. doi request reprint What is the optimal dietary intake of vitamin D for reducing fracture risk?
    Bess Dawson-Hughes
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Calcif Tissue Int 92:184-90. 2013
  3. doi request reprint Serum 25-hydroxyvitamin D and muscle atrophy in the elderly
    Bess Dawson-Hughes
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Proc Nutr Soc 71:46-9. 2012
  4. doi request reprint The potential impact of the National Osteoporosis Foundation guidance on treatment eligibility in the USA: an update in NHANES 2005-2008
    B Dawson-Hughes
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Osteoporos Int 23:811-20. 2012
  5. ncbi request reprint Comparative effects of oral aromatic and branched-chain amino acids on urine calcium excretion in humans
    B Dawson-Hughes
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Osteoporos Int 18:955-61. 2007
  6. ncbi request reprint Calcium and protein in bone health
    Bess Dawson-Hughes
    Calcium and Bone Metabolism Laboratory, The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Proc Nutr Soc 62:505-9. 2003
  7. ncbi request reprint Effect of dietary protein supplements on calcium excretion in healthy older men and women
    Bess Dawson-Hughes
    Bone Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 89:1169-73. 2004
  8. doi request reprint The potential impact of new National Osteoporosis Foundation guidance on treatment patterns
    B Dawson-Hughes
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Osteoporos Int 21:41-52. 2010
  9. pmc Treatment with potassium bicarbonate lowers calcium excretion and bone resorption in older men and women
    Bess Dawson-Hughes
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 94:96-102. 2009
  10. ncbi request reprint Serum 25-hydroxyvitamin D and functional outcomes in the elderly
    Bess Dawson-Hughes
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Am J Clin Nutr 88:537S-540S. 2008

Research Grants

  1. EFFECT OF POTASSIUM BICARBONATE ON BONE AND MUSCLE
    Bess Dawson Hughes; Fiscal Year: 2007
  2. NIH OSTEOPOROSIS & RELATED BONE DISEASES RESOURCE CENTER
    Bess Dawson Hughes; Fiscal Year: 2002

Collaborators

Detail Information

Publications88

  1. pmc An evaluation of the reliability of muscle fiber cross-sectional area and fiber number measurements in rat skeletal muscle
    Lisa Ceglia
    Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, Washington Street, Box 268, 800, Boston, MA, 02111, USA
    Biol Proced Online 15:6. 2013
    ....
  2. doi request reprint What is the optimal dietary intake of vitamin D for reducing fracture risk?
    Bess Dawson-Hughes
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Calcif Tissue Int 92:184-90. 2013
    ..Trials testing additional doses of vitamin D in different segments of the population are needed...
  3. doi request reprint Serum 25-hydroxyvitamin D and muscle atrophy in the elderly
    Bess Dawson-Hughes
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Proc Nutr Soc 71:46-9. 2012
    ..The minimal 25-hydroxyvitamin D level needed for benefit was 60 nmol/l...
  4. doi request reprint The potential impact of the National Osteoporosis Foundation guidance on treatment eligibility in the USA: an update in NHANES 2005-2008
    B Dawson-Hughes
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Osteoporos Int 23:811-20. 2012
    ....
  5. ncbi request reprint Comparative effects of oral aromatic and branched-chain amino acids on urine calcium excretion in humans
    B Dawson-Hughes
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Osteoporos Int 18:955-61. 2007
    ..The mechanisms involved are not certain but these findings suggest a role for the calcium sensor receptor...
  6. ncbi request reprint Calcium and protein in bone health
    Bess Dawson-Hughes
    Calcium and Bone Metabolism Laboratory, The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Proc Nutr Soc 62:505-9. 2003
    ..The possibility that Ca intake may influence the impact of dietary protein on the skeleton warrants further investigation...
  7. ncbi request reprint Effect of dietary protein supplements on calcium excretion in healthy older men and women
    Bess Dawson-Hughes
    Bone Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 89:1169-73. 2004
    ....
  8. doi request reprint The potential impact of new National Osteoporosis Foundation guidance on treatment patterns
    B Dawson-Hughes
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Osteoporos Int 21:41-52. 2010
    ....
  9. pmc Treatment with potassium bicarbonate lowers calcium excretion and bone resorption in older men and women
    Bess Dawson-Hughes
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 94:96-102. 2009
    ..Bicarbonate has been implicated in bone health in older subjects on acid-producing diets in short-term studies...
  10. ncbi request reprint Serum 25-hydroxyvitamin D and functional outcomes in the elderly
    Bess Dawson-Hughes
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Am J Clin Nutr 88:537S-540S. 2008
    ..Many elderly persons in the United States and elsewhere have serum 25-hydroxyvitamin D concentrations below these levels. For this reason, supplementation is likely to provide significant benefit to this segment of the population...
  11. ncbi request reprint Racial/ethnic considerations in making recommendations for vitamin D for adult and elderly men and women
    Bess Dawson-Hughes
    Bone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 80:1763S-6S. 2004
    ..Broad-based vitamin D supplementation is needed to remove vitamin D insufficiency as a contributing cause of osteoporosis...
  12. doi request reprint A revised clinician's guide to the prevention and treatment of osteoporosis
    Bess Dawson-Hughes
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Clin Endocrinol Metab 93:2463-5. 2008
  13. doi request reprint Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA
    B Dawson-Hughes
    Bone Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Osteoporos Int 19:449-58. 2008
    ....
  14. ncbi request reprint Response to teriparatide in patients with baseline 25-hydroxyvitamin D insufficiency or sufficiency
    Bess Dawson-Hughes
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111 1524, USA
    J Clin Endocrinol Metab 92:4630-6. 2007
    ..Serum 25-hydroxyvitamin D (25OHD) concentrations greater than 30 ng/ml have been recommended for lowering fracture risk...
  15. pmc Impact of supplementation with bicarbonate on lower-extremity muscle performance in older men and women
    B Dawson-Hughes
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Osteoporos Int 21:1171-9. 2010
    ..Bicarbonate reduced NAE, and the decrement was associated with a decrease in nitrogen excretion. Treatment also improved muscle power and endurance in the women...
  16. doi request reprint IOF position statement: vitamin D recommendations for older adults
    B Dawson-Hughes
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Osteoporos Int 21:1151-4. 2010
    ..This position paper of the International Osteoporosis Foundation makes recommendations for vitamin D nutrition in elderly men and women from an evidence-based perspective...
  17. ncbi request reprint Secondary hyperparathyroidism and bone turnover in elderly blacks and whites
    S S Harris
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 86:3801-4. 2001
    ..Recent public health efforts to promote higher calcium and vitamin D intakes, targeted predominantly to older Caucasians, should also be directed to older African-Americans...
  18. ncbi request reprint Weight and body mass index at menarche are associated with premenopausal bone mass
    M Blum
    Calcium and Metabolic Bone Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Osteoporos Int 12:588-94. 2001
    ..In conclusion, low body weight and low BMI at menarche appear to be significant predictors of reduced bone mass in healthy premenopausal women ages 40-45 years...
  19. ncbi request reprint Household tobacco smoke exposure is negatively associated with premenopausal bone mass
    M Blum
    Calcium and Metabolic Bone Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Osteoporos Int 13:663-8. 2002
    ....
  20. ncbi request reprint Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women
    S L Booth
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, USA
    Am J Clin Nutr 71:1201-8. 2000
    ..Vitamin K has been associated with bone mineral density (BMD) and risk of hip fracture. The apolipoprotein (apo) E4 allele (APOE*E4) has been associated with bone fracture through a putative effect on vitamin K transport in blood...
  21. ncbi request reprint Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women
    B Dawson-Hughes
    Jean Mayer US Department Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston 02111, USA
    Am J Clin Nutr 65:67-71. 1997
    ..More than 90% of the men and women had calcidiol concentrations below this value in the wintertime. The high prevalence of lower wintertime calcidiol values may increase risk of bone loss in elderly men and women...
  22. ncbi request reprint Effect of withdrawal of calcium and vitamin D supplements on bone mass in elderly men and women
    B Dawson-Hughes
    Calcium and Bone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston 02111, USA
    Am J Clin Nutr 72:745-50. 2000
    ..Supplementation with calcium and vitamin D reduces bone loss and prevents fractures in elderly people, but it is not known whether any lasting benefit remains if the supplements are discontinued...
  23. pmc 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services
    J S Buell
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Neurology 74:18-26. 2010
    ..However, no studies have examined the association between vitamin D status, dementia, and cranial MRI indicators of cerebrovascular disease (CVD)...
  24. pmc Alkaline diets favor lean tissue mass in older adults
    Bess Dawson-Hughes
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 87:662-5. 2008
    ....
  25. ncbi request reprint Factors related to the use of bone densitometry: survey responses of 494 primary care physicians in New England
    D H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 221 Longwood Avenue, Suite 341, Boston, MA 02115, USA
    Osteoporos Int 14:123-9. 2003
    ..Educational strategies aimed at improving the use of bone density testing should consider these factors...
  26. pmc Activation of the calcium sensing receptor stimulates gastrin and gastric acid secretion in healthy participants
    L Ceglia
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA, 02111, USA
    Osteoporos Int 20:71-8. 2009
    ..These findings indicate that the calcium sensor receptor plays a role in the regulation of gastric acid...
  27. ncbi request reprint Calcium and vitamin D supplements reduce tooth loss in the elderly
    E A Krall
    Department of Health Policy and Health Services Research, Boston University Goldman School of Dental Medicine, 715 Albany Street, Boston, MA O2118, USA
    Am J Med 111:452-6. 2001
    ..5; 95% CI: 0.2 to 0.9). CONCLUSION: These findings suggest that intake levels of calcium and vitamin D aimed at preventing osteoporosis have a beneficial effect on tooth retention...
  28. ncbi request reprint Recall of early menstrual history and menarcheal body size: after 30 years, how well do women remember?
    A Must
    Department of Family Medicine and Community Health, School of Medicine, Tufts University, Boston, MA 02111, USA
    Am J Epidemiol 155:672-9. 2002
    ..The failure to identify certain menstrual characteristics as exposures for subsequent disease may reflect limitations in the accuracy and precision of the recalled measures...
  29. ncbi request reprint Calcium supplement and bone medication use in a US Medicare health maintenance organization
    B Dawson-Hughes
    Calcium and Bone Metabolism Laboratory at the Jean Mayer USDA Human Nutrition Research Center, Boston, MA 02111, USA
    Osteoporos Int 13:657-62. 2002
    ..Based on the results of this survey, many elderly men and women may benefit from increased utilization of calcium supplements and bone-active medications...
  30. pmc Genetic and non-genetic correlates of vitamins K and D
    M K Shea
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Eur J Clin Nutr 63:458-64. 2009
    ..To assess the genetic and nongenetic correlates of circulating measures of vitamins K and D status in a community-based sample of men and women...
  31. pmc Body size and serum 25 hydroxy vitamin D response to oral supplements in healthy older adults
    Miriam Blum
    Bone Metabolism Laboratory, Jean Mayer USDA, HNRC on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Am Coll Nutr 27:274-9. 2008
    ..Since vitamin D insufficiency is readily amenable to supplementation, it is important to understand what factors are associated with serum 25 hydroxy vitamin D (25(OH)D) response to vitamin D supplementation...
  32. pmc Association between serum osteocalcin and markers of metabolic phenotype
    Anastassios G Pittas
    Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, 800 Washington Street, 268, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 94:827-32. 2009
    ..Osteocalcin has been reported to contribute to the regulation of glucose tolerance and insulin secretion and sensitivity in experimental animals...
  33. pmc The association of adiposity with parathyroid hormone in healthy older adults
    Arpita Patel Pitroda
    Division of Endocrinology, Tufts New England Medical Center, Boston, MA, USA
    Endocrine 36:218-23. 2009
    ..This is important in view of worldwide increases in overweight and obesity and the potential contribution of elevated PTH to morbidity and mortality...
  34. pmc Adulthood obesity is positively associated with adipose tissue concentrations of vitamin K and inversely associated with circulating indicators of vitamin K status in men and women
    M Kyla Shea
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 140:1029-34. 2010
    ..Additional studies are needed to further explore the relationships among body fat, storage of vitamin K in adipose tissue, and implications for vitamin K status and function...
  35. ncbi request reprint Leptin, body composition and bone mineral density in premenopausal women
    M Blum
    Calcium and Metabolic Bone Laboratory, Jean Mayer United States Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Calcif Tissue Int 73:27-32. 2003
    ..In summary, the results of this study suggest that for a given body weight, a higher proportion of fat and a higher serum leptin concentration have negative associations with bone mass in premenopausal women...
  36. doi request reprint A simple single serum method to measure fractional calcium absorption using dual stable isotopes
    L Ceglia
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Exp Clin Endocrinol Diabetes 118:653-6. 2010
    ..5% lower than with the 24-h urine method; however, it rank orders subjects accurately thus making it a useful alternative method in clinical research applications...
  37. ncbi request reprint Fitting nutrition into the medical model: the role of decision analytic cost-effectiveness techniques
    E M Ross
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Eur J Clin Nutr 53:S25-8. 1999
    ....
  38. pmc Vitamin K, circulating cytokines, and bone mineral density in older men and women
    M Kyla Shea
    US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 88:356-63. 2008
    ..Vitamin K modulates cytokines involved in bone turnover, including interleukin-6 (IL-6) and osteoprotegerin in vitro...
  39. ncbi request reprint The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults
    Anastassios G Pittas
    Department of Endocrinology, Diabetes, and Metabolism, Tufts New England Medical Center, Boston, MA 02111, USA
    Diabetes Care 30:980-6. 2007
    ..We sought to compare the effects of combined calcium and vitamin D supplementation versus placebo on blood glucose and markers of inflammation in nondiabetic adults aged > or =65 years...
  40. ncbi request reprint Associations between vitamin K biochemical measures and bone mineral density in men and women
    Sarah L Booth
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 89:4904-9. 2004
    ..Clinical trials are required to isolate any putative effects of vitamin K on rates of bone loss. The target population in these trials, particularly in regard to estrogen use, may be critical, as suggested by the findings of this study...
  41. pmc Effect of vitamin K supplementation on insulin resistance in older men and women
    Makiko Yoshida
    Jean Mayer US Department of Agriculture, Human Nutrition Research Center, Tufts University, Boston, Massachusetts, USA
    Diabetes Care 31:2092-6. 2008
    ..Vitamin K has a potentially beneficial role in insulin resistance, but evidence is limited in humans. We tested the hypothesis that vitamin K supplementation for 36 months will improve insulin resistance in older men and women...
  42. ncbi request reprint Childhood overweight and maturational timing in the development of adult overweight and fatness: the Newton Girls Study and its follow-up
    Aviva Must
    Department of Public Health and Family Medicine, School of Medicine, Tufts University, Boston, Massachusetts 02111, USA
    Pediatrics 116:620-7. 2005
    ..Although several studies have suggested that early menarche is associated with the development of adult overweight, few have accounted for childhood overweight before menarche...
  43. doi request reprint Therapy of osteoporosis with calcium and vitamin D
    Bess Dawson-Hughes
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    J Bone Miner Res 22:V59-63. 2007
    ....
  44. pmc Effect of vitamin K supplementation on bone loss in elderly men and women
    Sarah L Booth
    U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 93:1217-23. 2008
    ..Vitamin K has been implicated in bone health, primarily in observational studies. However, little is known about the role of phylloquinone supplementation on prevention of bone loss in men and women...
  45. doi request reprint Evaluation of an inexpensive calcium absorption index in healthy older men and women
    Lisa Ceglia
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Clin Endocrinol (Oxf) 72:22-5. 2010
    ....
  46. pmc Vitamin K supplementation and progression of coronary artery calcium in older men and women
    M Kyla Shea
    US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 89:1799-807. 2009
    ..A preventive role for vitamin K in CAC progression has been proposed on the basis of the properties of matrix Gla protein (MGP) as a vitamin K-dependent calcification inhibitor...
  47. pmc Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study
    M Kyla Shea
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Epidemiol 167:313-20. 2008
    ..The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation...
  48. pmc Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status
    Michael D Crosier
    USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Sci Vitaminol (Tokyo) 55:112-9. 2009
    ..Polymorphisms in genes encoding enzymes involved in vitamin K metabolism may modulate plasma concentrations of phylloquionone and percent carboxylation of osteocalcin...
  49. ncbi request reprint Reduced sun exposure does not explain the inverse association of 25-hydroxyvitamin D with percent body fat in older adults
    Susan S Harris
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 92:3155-7. 2007
    ..Greater adiposity is associated with lower blood levels of 25-hydroxyvitamin D [25(OH)D]. The extent to which this results from reduced sun exposure among heavier individuals is unknown...
  50. ncbi request reprint Interaction of dietary calcium and protein in bone health in humans
    Bess Dawson-Hughes
    Calcium and Bone Metabolism Laboratory at the Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:852S-854S. 2003
    ..In conclusion, an adequate calcium intake may help promote a favorable effect of dietary protein on the skeleton in older individuals...
  51. ncbi request reprint Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
    Heike A Bischoff-Ferrari
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 84:18-28. 2006
    ..The implications of higher doses for the entire adult population should be addressed in future studies...
  52. ncbi request reprint Calcium intake influences the association of protein intake with rates of bone loss in elderly men and women
    Bess Dawson-Hughes
    Calcium and Bone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 75:773-9. 2002
    ..There is currently no consensus on the effect of dietary protein intake on the skeleton, but there is some indication that low calcium intakes adversely influence the effect of dietary protein on fracture risk...
  53. pmc No effect of bicarbonate treatment on insulin sensitivity and glucose control in non-diabetic older adults
    Susan S Harris
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Endocrine 38:221-6. 2010
    ..001) but had no effect on fasting plasma glucose, serum insulin, or HOMA-IR. In conclusion, bicarbonate supplementation does not appear to improve insulin sensitivity or glucose control in non-diabetic older adults...
  54. pmc Multi-step immunofluorescent analysis of vitamin D receptor loci and myosin heavy chain isoforms in human skeletal muscle
    Lisa Ceglia
    Tufts Medical Center, Boston, MA, USA
    J Mol Histol 41:137-42. 2010
    ..This method can thus be a useful approach to study potential relationships between muscle fiber subtypes and vitamin D receptor expression...
  55. ncbi request reprint Vitamin K intake and bone mineral density in women and men
    Sarah L Booth
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 77:512-6. 2003
    ..Low dietary vitamin K intake has been associated with an increased risk of hip fracture in men and women. Few data exist on the association between dietary vitamin K intake and bone mineral density (BMD)...
  56. pmc Potassium bicarbonate attenuates the urinary nitrogen excretion that accompanies an increase in dietary protein and may promote calcium absorption
    Lisa Ceglia
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 94:645-53. 2009
    ..Protein is an essential component of muscle and bone. However, the acidic byproducts of protein metabolism may have a negative impact on the musculoskeletal system, particularly in older individuals with declining renal function...
  57. ncbi request reprint Plasma vitamin D and 25OHD responses of young and old men to supplementation with vitamin D3
    Susan S Harris
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University Boston, Massachusetts 02111, USA
    J Am Coll Nutr 21:357-62. 2002
    ..This study was conducted to determine whether there are age differences in the plasma parent vitamin D and 25-hydroxyvitamin D (25OHD) responses to eight weeks of supplementation with 20 microg/day of vitamin D3...
  58. ncbi request reprint Vitamin D status of an outpatient clinic population
    L Margiloff
    New England Medical Center, Boston, MA 02111, USA
    Calcif Tissue Int 69:263-7. 2001
    ..In conclusion, at their current dietary vitamin D intake levels, most patients at this latitude will need vitamin D supplements in the wintertime...
  59. pmc Vitamin D(3) in fat tissue
    Miriam Blum
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA, 02111, USA
    Endocrine 33:90-4. 2008
    ..Compatible with the long-standing concept that fat tissue is a storage site for vitamin D, fat tissue and serum vitamin D(3) concentrations were positively correlated...
  60. ncbi request reprint Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials
    Heike A Bischoff-Ferrari
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 293:2257-64. 2005
    ..The role and dose of oral vitamin D supplementation in nonvertebral fracture prevention have not been well established...
  61. ncbi request reprint Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation
    Thomas Dietrich
    Department of Health Policy and Health Services Research, Boston University Goldman School of Dental Medicine, Boston, MA 02118, USA
    Am J Clin Nutr 82:575-80. 2005
    ..Vitamin D has been shown to have immunomodulatory effects in in vitro and in animal studies. However, data from clinical studies of inflammatory diseases are scarce...
  62. ncbi request reprint Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials
    Heike A Bischoff-Ferrari
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 86:1780-90. 2007
    ..The role of total calcium intake in the prevention of hip fracture risk has not been well established...
  63. ncbi request reprint Insulin-like growth factor binding proteins 4 and 5 and bone mineral density in elderly men and women
    D Karasik
    Hebrew Rehabilitation Center for Aged, Research and Training Institute and Harvard Medical School Division on Aging, Boston, MA, USA
    Calcif Tissue Int 71:323-8. 2002
    ..No other associations were observed for BMD at any other site. Further study is necessary for elucidation of the gender differences in the possible influence of IGF system components on bone mass...
  64. pmc The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis
    Anastassios G Pittas
    Division of Endocrinology, Diabetes and Metabolism, Tufts New England Medical Center, Boston, MA 02111, USA
    J Clin Endocrinol Metab 92:2017-29. 2007
    ..When data were available to combine, meta-analyses were performed, and summary odds ratios (OR) are presented...
  65. ncbi request reprint Effect of Vitamin D on falls: a meta-analysis
    Heike A Bischoff-Ferrari
    Division of Aging, Department of Medicine, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02120, USA
    JAMA 291:1999-2006. 2004
    ..Falls among elderly individuals occur frequently, increase with age, and lead to substantial morbidity and mortality. The role of vitamin D in preventing falls among elderly people has not been well established...
  66. ncbi request reprint Vitamin D and calcium intake in relation to type 2 diabetes in women
    Anastassios G Pittas
    Division of Endocrinology, Diabetes and Metabolism, Tufts New England Medical Center, 750 Washington Street 268, Boston, MA 02111, USA
    Diabetes Care 29:650-6. 2006
    ..The purpose of this study was to prospectively examine the association between vitamin D and calcium intake and risk of type 2 diabetes...
  67. pmc Vitamin D is associated with cognitive function in elders receiving home health services
    Jennifer S Buell
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 64:888-95. 2009
    ..The objective of this study was to examine the association between 25-hydroxyvitamin D, 25(OH)D, and cognitive function...
  68. pmc Matrix Gla protein polymorphisms are associated with coronary artery calcification in men
    Michael D Crosier
    USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    J Nutr Sci Vitaminol (Tokyo) 55:59-65. 2009
    ..The results of this study suggest a role for MGP genetic variants in coronary atherosclerosis among men that is not reflected in serum MGP concentrations...
  69. ncbi request reprint Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y
    Heike A Bischoff-Ferrari
    Division of Aging, The Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, 1620 Tremont Street, Boston, MA 02120, USA
    Am J Clin Nutr 80:752-8. 2004
    ..Vitamin D may improve muscle strength through a highly specific nuclear receptor in muscle tissue...
  70. ncbi request reprint Metabolic, psychological, and health correlates of dietary restraint in healthy postmenopausal women
    G P Bathalon
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Gerontol A Biol Sci Med Sci 56:M206-11. 2001
    ..Further work is needed to determine the relevance of these results to the general population...
  71. pmc Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women
    Anastassios G Pittas
    Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, Massachusetts, USA
    Diabetes Care 33:2021-3. 2010
    ..To determine the association between 25-hydroxyvitamin D (25-OHD) concentration and risk of incident type 2 diabetes...
  72. pmc Type of dietary fat is associated with the 25-hydroxyvitamin D3 increment in response to vitamin D supplementation
    Sathit Niramitmahapanya
    Bone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 96:3170-4. 2011
    ..Mono- and polyunsaturated fats may have opposing effects on vitamin D absorption...
  73. pmc Vitamin D and diabetes
    Anastassios G Pittas
    Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA 02111, United States
    J Steroid Biochem Mol Biol 121:425-9. 2010
    ..Therefore, the hypothesis that vitamin D may modify diabetes risk needs to be confirmed in trials specifically designed for that purpose...
  74. ncbi request reprint The urgent need to recommend an intake of vitamin D that is effective
    Reinhold Vieth
    Am J Clin Nutr 85:649-50. 2007
  75. ncbi request reprint Calcium plus vitamin D and the risk of fractures
    Bess Dawson-Hughes
    N Engl J Med 354:2285-7; author reply 2285-7. 2006
  76. ncbi request reprint Dietary acid-base balance, bone resorption, and calcium excretion
    Ramina Jajoo
    Division of Rheumatology, Tufts New England Medical Center, Bone Metabolism Laboratory at the Jean Mayer, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Am Coll Nutr 25:224-30. 2006
    ..This study was conducted to examine associations between diet-induced changes in net acid excretion (NAE) and changes in serum parathyroid hormone (PTH), bone resorption, and calcium excretion over a longer period of 60 days...
  77. ncbi request reprint Preventing osteoporosis-related fractures: an overview
    Margery Gass
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0526, USA
    Am J Med 119:S3-S11. 2006
    ..An important approach to reducing the rate of fractures is first to target our treatments to patients at high risk for fracture and then to develop strategies to improve treatment continuation rates...
  78. ncbi request reprint Estimates of optimal vitamin D status
    Bess Dawson-Hughes
    Osteoporos Int 16:713-6. 2005
    ..Based on the available evidence, we believe that if older men and women maintain serum levels of 25(OH)D that are higher than the consensus median threshold of 75 nmol/l, they will be at lower risk of fracture...
  79. ncbi request reprint Precision of bone mineral density scans at the proximal tibia in osteoarthritic subjects
    Edward Vazquez
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Clin Densitom 7:364-7. 2004
    ..A larger study is needed to determine whether proximal tibia BMD measurements have research or clinical application for osteoarthritis or other conditions...
  80. ncbi request reprint Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults
    Heike A Bischoff-Ferrari
    Division of Ageing, The Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Boston, Massachusetts, USA
    Am J Med 116:634-9. 2004
  81. ncbi request reprint Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial
    Heike A Bischoff-Ferrari
    Department of Rheumatology and Institute for Physical Medicine, University Hospital Zurich, Zurich, Switzerland
    Arch Intern Med 166:424-30. 2006
    ..However, little is known about whether supplemental cholecalciferol plus calcium citrate malate will lower the long-term risk of falling in men, active older individuals, and older individuals with higher 25-hydroxyvitamin D levels...
  82. ncbi request reprint Calcium supplement and osteoporosis medication use in women and men with recent fractures
    Alejandra Pro-Risquez
    Brookline Associates of Internal Medicine, Brighton, MA, USA
    Osteoporos Int 15:689-94. 2004
    ..This suggests that the primary care physician is well positioned to bring about much needed change in the quality of care of fracture patients...
  83. ncbi request reprint Lack of effect of calcium intake on the 25-hydroxyvitamin d response to oral vitamin D3
    Rula Goussous
    Division of Endocrinology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 90:707-11. 2005
    ..6, 8.7) nmol/liter. In older men and women, the level of calcium intake, within the range of 500-1500 mg/d, does not have an important effect on the rise in serum 25(OH)D that occurs in response to 800 IU (20 microg)/d vitamin D(3)...
  84. ncbi request reprint Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population
    Thomas Dietrich
    Department of Periodontology and the Department of Oral Surgery and Oral Radiology, Charite, Humboldt University of Berlin, Germany
    Am J Clin Nutr 80:108-13. 2004
    ..Periodontal disease (PD) is a common chronic inflammatory disease and an important risk factor for tooth loss. Vitamin D might affect periodontal disease risk via an effect on bone mineral density (BMD) or via immunomodulatory effects...
  85. pmc Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification
    Christopher J O'Donnell
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 26:2769-74. 2006
    ..Matrix Gla protein (MGP) is an inhibitor of calcification in vivo. However, little is known regarding the distribution of circulating MGP and its associations with CHD risk factors or with CAC in humans...
  86. ncbi request reprint Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025
    Russel Burge
    Procter and Gamble Pharmaceuticals and Personal Health, Mason, OH, USA
    J Bone Miner Res 22:465-75. 2007
    ..Total fractures were >2 million, costing nearly $17 billion in 2005. Men account for >25% of the burden. Rapid growth in the disease burden is projected among nonwhite populations...
  87. ncbi request reprint Precision of single vs bilateral hip bone mineral density scans
    Jennifer White
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Clin Densitom 6:159-62. 2003
    ..94% for total body fat tissue, and 0.77% for total body nonfat soft tissue. We conclude that precision overall is excellent and that femoral neck precision can be improved with bilateral compared with the traditional single hip scans...
  88. ncbi request reprint Where do we stand on vitamin D?
    Heike Annette Bischoff-Ferrari
    Department of Rheumatology and Institute for Physical Medicine, University Hospital Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland
    Bone 41:S13-9. 2007
    ....

Research Grants5

  1. EFFECT OF POTASSIUM BICARBONATE ON BONE AND MUSCLE
    Bess Dawson Hughes; Fiscal Year: 2007
    ....
  2. NIH OSTEOPOROSIS & RELATED BONE DISEASES RESOURCE CENTER
    Bess Dawson Hughes; Fiscal Year: 2002
    ..Specific efforts include supporting the National Osteoporosis Data Group, collecting and disseminating definitive statistics on bone diseases and on conditions co-morbid with osteoporosis, and preparing summary reports. ..