Genomes and Genes
Affiliation: Tufts University
- Cough and phlegm are important predictors of health status in smokers without COPDYvonne F Heijdra
Pulmonary Department, University Medical Center, St. Radboud, Nijmegen, The Netherlands
Chest 121:1427-33. 2002..CONCLUSIONS: In smokers without COPD, the abnormal SGRQ score is due to the noxious effect of cigarette smoke, resulting in cough and phlegm, independent of its physiologic effects...
- Change in the BODE index reflects disease modification in COPD: lessons from lung volume reduction surgeryBartolome R Celli
Chest 129:835-6. 2006
- Longitudinal inspiratory capacity changes in chronic obstructive pulmonary diseaseBartolome R Celli
Pulmonary Division, Brigham and Women s Hospital, Boston, MA, USA
Respir Res 13:66. 2012..The changes in inspiratory capacity (IC) over time in chronic obstructive pulmonary disease (COPD) patients are unknown. The Understanding Potential Long-term Impacts on Function with Tiotropium (UPLIFT®) trial included IC measurements...
- Adverse health consequences in COPD patients with rapid decline in FEV1--evidence from the UPLIFT trialSteven Kesten
Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, USA
Respir Res 12:129. 2011..The rate of decline in forced expiratory volume in 1 second (FEV1) is representative of the natural history of COPD. Sparse information exists regarding the associations between the magnitude of annualised loss of FEV1 with other endpoints...
- Health status in the TORCH study of COPD: treatment efficacy and other determinants of changePaul W Jones
Department of Cardiac and Vascular Sciences, St George s Hospital, University of London, London, UK
Respir Res 12:71. 2011..Little is known about factors that determine health status decline in clinical trials of COPD...
- Markers of exacerbation severity in chronic obstructive pulmonary diseaseLuigi G Franciosi
Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
Respir Res 7:74. 2006..In an attempt to find the best surrogates for exacerbations, we have reviewed the literature to identify which of these markers change in a consistent manner with the severity of the exacerbation event...
- Gender and respiratory factors associated with dyspnea in chronic obstructive pulmonary diseaseJuan P de Torres
Respiratory Research Unit, Hospital Nuestra Sra de Candelaria, Tenerife, Spain
Respir Res 8:18. 2007..We had shown that COPD women expressed more dyspnea than men for the same degree of airway obstruction...
- Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trialNicola A Hanania
Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA
Respir Res 12:6. 2011..Debate continues as to whether acute bronchodilator responsiveness (BDR) predicts long-term outcomes in COPD. Furthermore, there is no consensus on a threshold for BDR...
- Characterisation of COPD heterogeneity in the ECLIPSE cohortAlvar Agusti
Thorax Institute, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Spain
Respir Res 11:122. 2010..Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE)...
- Gender associated differences in determinants of quality of life in patients with COPD: a case series studyJuan P de Torres
Respiratory Research Unit, Hospital Nuestra Sra de Candelaria, Tenerife, Spain
Health Qual Life Outcomes 4:72. 2006..Quality of Life (QoL) has become an important outcome in COPD patients. The aim of our study was to explore factors contributing to gender differences in Quality of Life of COPD patients...
- Venous admixture in COPD: pathophysiology and therapeutic approachesChristopher B Cooper
David Geffen School of Medicine, University of California, Los Angeles, California 90095 1690, USA
COPD 5:376-81. 2008..This approach to treatment could have significant impact for patients with COPD but should also benefit any patient with chronic hypoxemia that impairs exercise performance...
- Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH studyBartolome R Celli
Tufts University School of Medicine, Pulmonary and Critical Care Division, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
Am J Respir Crit Care Med 178:332-8. 2008..Chronic obstructive pulmonary disease (COPD) is characterized by an accelerated decline in lung function. No drug has been shown conclusively to reduce this decline...
- Roger s. Mitchell lecture. Chronic obstructive pulmonary disease phenotypes and their clinical relevanceBartolome R Celli
Pulmonary and Critical Care Services, Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, MA 02135, USA
Proc Am Thorac Soc 3:461-5. 2006..The hope is that, coupled with primary and secondary prevention, we can reverse the current epidemic and we can improve the well-being of patients affected by COPD...
- Update on the management of COPDBartolome R Celli
Pulmonary and Critical Care Medicine, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
Chest 133:1451-62. 2008..Ultimately, the advent of newer and more effective therapies will lead to a decline in the contribution of this disease to poor world health...
- Novel concepts in the pharmacotherapy of chronic obstructive pulmonary diseaseBartolome R Celli
Division of Pulmonary and Critical Care Medicine, Caritas St Elizabeth s Medical Center, Boston, Stany Zjednoczone
Pneumonol Alergol Pol 77:82-90. 2009..Ultimately, the advent of newer and more effective therapies will lead to a decline in the contribution of this disease to poor world health...
- Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary diseaseBartolome Celli
Brigham and Women s Hospital and St Elizabeth s Medical Center, Boston, MA 02115, USA
Am J Respir Crit Care Med 180:948-55. 2009..Mortality and its causes was a secondary endpoint in UPLIFT...
- Future perspectives in COPDBartolome Celli
Caritas St Elizabeth s Medical Center, Department of Medicine, Tufts University, Boston, USA
Respir Med 99:S41-8. 2005..Many questions remain to be answered, but a comprehensive approach is now considered essential to the life-long management of COPD, and will undoubtedly reduce the considerable socio-economic burden of COPD...
- A 62-year-old woman with chronic obstructive pulmonary diseaseBartolome R Celli
Tufts University, USA
JAMA 290:2721-9. 2003
- Bronchodilator responsiveness and onset of effect with budesonide/formoterol pMDI in COPDBartolome R Celli
Harvard University, Brigham and Women s Hospital, Pulmonary and Critical Care Medicine, Boston, MA 02115, USA
Respir Med 105:1176-88. 2011..We also evaluated the speed of onset of bronchodilation...
- The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary diseaseBartolome R Celli
COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
N Engl J Med 350:1005-12. 2004..We hypothesized that a multidimensional grading system that assessed the respiratory and systemic expressions of COPD would better categorize and predict outcome in these patients...
- Sex differences in mortality and clinical expressions of patients with chronic obstructive pulmonary disease. The TORCH experienceBartolome Celli
Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 183:317-22. 2011..Objectives: Determine sex differences in survival, causes of death, and patient-centered outcomes in the 3-year Toward a Revolution in COPD Health (TORCH) study...
- Predictors of mortality in COPDBartolome R Celli
Tufts University, St Elizabeth s Medical Center, 736 Cambridge St, Boston, MA 02135, USA
Respir Med 104:773-9. 2010..This article reviews these predictors of mortality in COPD...
- Profiling serum biomarkers in patients with COPD: associations with clinical parametersVictor Pinto Plata
Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, Massachusetts 02135, USA
Thorax 62:595-601. 2007..A systematic analysis was undertaken of multiple protein analytes in the serum of well characterised patients with COPD and matched controls using novel protein microarray platform (PMP) technology...
- Cardiovascular safety of tiotropium in patients with COPDBartolome Celli
Carita St Elizabeth s Medical Center, Boston, MA, USA
Chest 137:20-30. 2010..The clinical trial safety database for tiotropium has been augmented with a 4-year trial in patients with COPD, which provides an opportunity to better evaluate the cardiovascular (CV) profile of tiotropium...
- Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumesBartolome Celli
Pulmonary and Critical Care Division, St Elizabeth s Medical Center, Boston, MA 02135, USA
Chest 124:1743-8. 2003..We sought to evaluate changes in resting IC and lung volumes after long-term administration of tiotropium...
- Effect of tiotropium in men and women with COPD: results of the 4-year UPLIFT trialDonald Tashkin
Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1690, USA
Respir Med 104:1495-504. 2010..Gender differences may occur in many chronic diseases. We have examined the influence of gender in chronic obstructive pulmonary disease (COPD) on long-term responses to tiotropium...
- Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary diseaseDeog Kyeom Kim
Channing Division of Network Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 186:1238-47. 2012..A genome-wide association study (GWAS) for circulating chronic obstructive pulmonary disease (COPD) biomarkers could identify genetic determinants of biomarker levels and COPD susceptibility...
- Biological lung volume reduction: a new bronchoscopic therapy for advanced emphysemaJohn Reilly
Brigham and Women s Hospital, Pulmonary Critical Care Medicine, 75 Francis St, Boston, MA 02115 6110, USA
Chest 131:1108-13. 2007..This report summarizes the initial clinical experience including a 3-month follow-up using this technique in humans...
- Cardiopulmonary exercise testing: relevant but underusedDaniel E Forman
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Postgrad Med 122:68-86. 2010..In this article, we provide an overview of CPX principles and testing logistics, as well as some of the clinical contexts in which it can enhance patient care...
- Resting handgrip force and impaired cardiac function at rest and during exercise in COPD patientsFelipe Cortopassi
Division of Pulmonary, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
Respir Med 105:748-54. 2011..Cardiac function measured as the oxygen pulse (O(2) pulse) is impaired during exercise (CPET) in patients with COPD. We investigated the relationship between handgrip force and O(2) pulse in COPD and controls...
- Proposal for a multidimensional staging system for chronic obstructive pulmonary diseaseBartolome R Celli
Department of Pulmonary and Critical Care Medicine, Tufts University, Boston, MA 02135, USA
Respir Med 99:1546-54. 2005..Although the staging boundaries were based on existing literature, they have proven useful in predicting survival. We conclude that a multidimensional grading system is useful to assess the impact of COPD...
- Comorbidities and risk of mortality in patients with chronic obstructive pulmonary diseaseMiguel Divo
Pulmonary and Critical Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Respir Crit Care Med 186:155-61. 2012..Patients with chronic obstructive pulmonary disease (COPD) are afflicted by comorbidities. Few studies have prospectively evaluated COPD comorbidities and mortality risk...
- Power of outcome measurements to detect clinically significant changes in pulmonary rehabilitation of patients with COPDJuan Pablo de Torres
Pulmonary and Critical Care Division, St. Elizabeth's Medical Center, Boston 02135-2997, USA
Chest 121:1092-8. 2002..The 6MWD evaluates a unique domain not related to quality of life. Due to their simplicity and sensitivity, VAS at peak exercise, 6MWD, and CRQ may be the best practical tools to evaluate responsiveness to PR...
- Predictors of Survival in COPD: more than just the FEV1Bartolome R Celli
Caritas St Elizabeth s Medical Center, Boston, MA, USA
Respir Med 102:S27-35. 2008....
- Differences in cardiopulmonary exercise test results by American Thoracic Society/European Respiratory Society-Global Initiative for Chronic Obstructive Lung Disease stage categories and genderVictor M Pinto-Plata
Division of Pulmonary, Critical Care and Sleep Medicine, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge St, Boston, MA 02135, USA
Chest 132:1204-11. 2007..We hypothesized that exercise performance measured by cardiopulmonary exercise test (CPET) results should decline significantly with each disease stage, independent of gender...
- The 6-min walk distance, peak oxygen uptake, and mortality in COPDClaudia G Cote
Pulmonary and Critical Care Medicine, Bay Pines VA Health Care System, 10, 000 Bay Pines Blvd, Bay Pines, FL 33744, USA
Chest 132:1778-85. 2007..993 to 0.999; p < 0.01) had a stronger association than the peak Vo2 (HR, 0.971; 95% CI, 0.959 to 1.000; p = 0.050) with mortality. This study shows the 6MWD is as good predictor of mortality as the peak Vo2 in patients with COPD...
- Systemic cytokines, clinical and physiological changes in patients hospitalized for exacerbation of COPDVictor M Pinto Plata
Division of Pulmonary and Critical Care Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
Chest 131:37-43. 2007..Systemic inflammation in patients with COPD may worsen during exacerbations, but there is limited information relating levels of systemic inflammatory markers with symptoms and physiologic changes during an exacerbation..
- A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13Michael H Cho
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Hum Mol Genet 21:947-57. 2012..08 and 0.04) and severe (GOLD 3&4) COPD (P = 0.09 and 0.017). This region includes RAB4B, EGLN2, MIA and CYP2A6, and has previously been identified in association with cigarette smoking behavior...
- Use of proteomic patterns of serum biomarkers in patients with chronic obstructive pulmonary disease: correlation with clinical parametersVictor Pinto-Plata
Pulmonary-Critical Care Medicine, Caritas St. Elizabeth's Medical Center, 736 Cambridge Street, Boston, MA 02135
Proc Am Thorac Soc 3:465-6. 2006
- Genome-wide association study of smoking behaviours in patients with COPDMateusz Siedlinski
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Thorax 66:894-902. 2011..Associations of CHRNA3/CHRNA5 and CYP2A6 loci with CPD and DBH with smoking cessation are also likely of importance in the smoking behaviours of patients with COPD...
- Gene expression profiling of human lung tissue from smokers with severe emphysemaAvrum Spira
The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, R304, Boston, MA 02118, USA
Am J Respir Cell Mol Biol 31:601-10. 2004....
- Pulmonary rehabilitationBartolome R Celli
St. Elizabeth's Medical Center, Tufts University, Boston, MA, USA
Isr Med Assoc J 5:443-8. 2003
- Lung volume reduction therapies for advanced emphysema: an updateRobert L Berger
Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Deaconess, Boston, MA 02215, USA
Chest 138:407-17. 2010..Although there is promise of limited therapeutic influence, the available information is not sufficient to recommend use of bronchoscopic strategies for treating emphysema...
- Airway obstruction in never smokers: results from the Third National Health and Nutrition Examination SurveyBartolome R Celli
Caritas St. Elizabeth's Medical Center, Tufts University Medical School, Boston, Mass, USA
Am J Med 118:1364-72. 2005..COPD may explain much of the remainder, although known risk factors were not explanatory in this dataset. Recommendations that lung health screening programs be limited to smokers should be reconsidered...
- Longitudinal change in the BODE index predicts mortality in severe emphysemaFernando J Martinez
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0360, USA
Am J Respir Crit Care Med 178:491-9. 2008..We hypothesized that decrease in a modified BODE (mBODE) would predict survival in National Emphysema Treatment Trial (NETT) patients...
- Chronic obstructive pulmonary disease: from unjustified nihilism to evidence-based optimismBartolome R Celli
Department of Medicine, Tufts University
Proc Am Thorac Soc 3:58-65. 2006..The advent of newer and more effective therapies will lead to a decline in the contribution of this disease to poor world health...
- Tracheobronchitis caused by methicillin-resistant Staphylococcus aureus as a cause of chronic wheezing in a non-ventilated adult patient with tracheobronchomalaciaTheodoros Kelesidis
Department of Medicine, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
Respiration 80:148-56. 2010..Physicians should be aware of the diagnosis of tracheomalacia in adults, which can masquerade as persistent asthma and may be associated with the development of serious infections including MRSA tracheobronchitis...
- Discrepancy in the use of confirmatory tests in patients hospitalized with the diagnosis of chronic obstructive pulmonary disease or congestive heart failureMahendra Damarla
Division of Pulmonary and Critical Care Medicine, Caritas St Elizabeth's Medical Center, Boston, Massachusetts 02135, USA
Respir Care 51:1120-4. 2006..To impact the increasingly important problem of COPD, we must raise awareness of the need to confirm its diagnosis and severity with spirometry...
- Deep breath reversal and exponential return of methacholine-induced obstruction in asthmatic and nonasthmatic subjectsAndrew C Jackson
Biomedical Engineering Dept, Boston Univ, 44 Cummington St, Boston, MA 02215, USA
J Appl Physiol 96:137-42. 2004..19 +/- 4.95 and 7.14 +/- 3.56 cmH2O.l-1.s, respectively). The monoexponential recovery suggests a first-order process such as airway wall-parenchymal tissue interdependence or renewed constriction of airway smooth muscle...
- Comorbidities, patient knowledge, and disease management in a national sample of patients with COPDR Graham Barr
Division of General Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Am J Med 122:348-55. 2009..We evaluated the prevalence of these comorbid conditions and compared testing, patient knowledge, and management in a national sample of patients with COPD...
- Chronic respiratory failure after lung resection: the role of pulmonary rehabilitationBartolome R Celli
Division of Pulmonary and Critical Care Medicine, Caritas St Elizabeth s Medical Center, Seton 3 Pulmonary, 736 Cambridge Street, Brighton, MA 02135, USA
Thorac Surg Clin 14:417-28. 2004..Currently, pulmonary rehabilitation should be made available to all patients with symptomatic respiratory disease and be an integral part of any program considering high-risk surgery...
- Physician and patient perceptions in COPD: the COPD Resource Network Needs Assessment SurveyR Graham Barr
Division of General Medicine, Department of Medicine, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY, USA
Am J Med 118:1415. 2005..National data are lacking on patient and physician perceptions of and patterns of care for COPD...
- Pulmonary rehabilitation improves depression, anxiety, dyspnea and health status in patients with COPDHildegarde Paz Díaz
Pulmonary Division, Hospital Universitario de Caracas, Universidad Central de Venezuela, Caracas, Venezuela
Am J Phys Med Rehabil 86:30-6. 2007..To determine the impact of an 8-wk program of comprehensive pulmonary rehabilitation on depression, anxiety, dyspnea, and health-related quality of life in patients with chronic obstructive pulmonary disease (COPD)...
- Predicting mortality in chronic obstructive pulmonary disease: chasing the "Holy Grail"Bartolome R Celli
Am J Respir Crit Care Med 173:1298-9. 2006
- Muscle strength and exercise kinetics in COPD patients with a normal fat-free mass index are comparable to control subjectsYvonne F Heijdra
Pulmonary Department, University Medical Center St. Radboud, Nijmegen, The Netherlands
Chest 124:75-82. 2003..Also, a normal body composition was found in nearly all COPD patients. This argues against the existence of a clinically significant systemic myopathy in most stable patients with severe COPD and normal FFMI...
- C-reactive protein levels and survival in patients with moderate to very severe COPDJuan P de Torres
Respiratory Research Unit, Hospital Ntra Sra de Candelaria, Canary Islands, Tenerife, Spain
Chest 133:1336-43. 2008..In epidemiologic studies, CRP level is associated with all-cause mortality in patients with mild-to-moderate disease...
- Gender and COPD in patients attending a pulmonary clinicJuan P de Torres
Respiratory Research Unit, Hospital Nuestra Sra de Candelaria, Tenerife, Spain
Chest 128:2012-6. 2005..To compare gender differences in the clinical expression of COPD patients attending a pulmonary clinic...
- What is the best pharmacological treatment to prevent exacerbation of chronic obstructive pulmonary disease?Bartolome R Celli
Pol Arch Med Wewn 118:172-4. 2008
- Distance and oxygen desaturation during the 6-min walk test as predictors of long-term mortality in patients with COPDCiro Casanova
Pulmonary Department, Hospital La Candelaria, Carretera del Rosario n degrees 145, 38010 Santa Cruz de Tenerife, Spain
Chest 134:746-52. 2008..Little is known about its prognostic value in patients with a wider range of COPD severity, living in different countries, and the potential additional impact of oxygen desaturation measured during the test...
- Inspiratory-to-total lung capacity ratio predicts mortality in patients with chronic obstructive pulmonary diseaseCiro Casanova
Respiratory Research Institute, Hospital Universitario La Candelaria, Carretera del Rosario s n, 38010 Santa Cruz de Tenerife, Spain
Am J Respir Crit Care Med 171:591-7. 2005..We propose that this ratio be considered in the assessment of patients with chronic obstructive pulmonary disease...
- New treatment strategies for COPD. Pairing the new with the tried and trueClaudia G Cote
University of South Florida College of Medicine, Tampa, USA
Postgrad Med 117:27-34. 2005..With all of these options, a nihilistic attitude toward management of COPD is not justified...
- Lung volume reduction surgery vs medical treatment: for patients with advanced emphysemaJohn D Miller
McMaster University, Hamilton Ontarion, Canada
Chest 127:1166-77. 2005..CONCLUSION: Six months after randomization, LVRS produced better palliation than optimal medical therapy in patients with advanced emphysema...
- Markers of disease severity in chronic obstructive pulmonary diseaseLuigi G Franciosi
Gorlaeus Laboratories, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
Pulm Pharmacol Ther 19:189-99. 2006....
- Predictors of mortality in chronic obstructive pulmonary diseaseClaudia G Cote
University of South Florida, Tampa, FL, USA
Clin Chest Med 28:515-24, v. 2007..It also discusses the ability of an integrated, multidimensional tool to more broadly characterize COPD severity, assess response to therapeutic interventions and exacerbations, and predict mortality...
- A comparison of 5-day courses of dirithromycin and azithromycin in the treatment of acute exacerbations of chronic obstructive pulmonary diseaseRichard S Castaldo
SUNY Buffalo School of Medicine, Buffalo, New York, USA
Clin Ther 25:542-57. 2003..There were insufficient data to permit meaningful comparison of the bacteriologic efficacy of these macrolide antibiotics...