Bartolome Celli

Summary

Affiliation: Tufts University School of Medicine
Country: USA

Publications

  1. ncbi Roger s. Mitchell lecture. Chronic obstructive pulmonary disease phenotypes and their clinical relevance
    Bartolome R Celli
    Pulmonary and Critical Care Services, Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, MA 02135, USA
    Proc Am Thorac Soc 3:461-5. 2006
  2. ncbi Chronic obstructive pulmonary disease: from unjustified nihilism to evidence-based optimism
    Bartolome R Celli
    Department of Medicine, Tufts University
    Proc Am Thorac Soc 3:58-65. 2006
  3. ncbi Change in the BODE index reflects disease modification in COPD: lessons from lung volume reduction surgery
    Bartolome R Celli
    Chest 129:835-6. 2006
  4. ncbi Predicting mortality in chronic obstructive pulmonary disease: chasing the "Holy Grail"
    Bartolome R Celli
    Am J Respir Crit Care Med 173:1298-9. 2006
  5. ncbi Systemic cytokines, clinical and physiological changes in patients hospitalized for exacerbation of COPD
    Victor M Pinto-Plata
    Division of Pulmonary and Critical Care Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Chest 131:37-43. 2007
  6. ncbi Chronic respiratory failure after lung resection: the role of pulmonary rehabilitation
    Bartolome R Celli
    Division of Pulmonary and Critical Care Medicine, Caritas St Elizabeth s Medical Center, Seton 3 Pulmonary, 736 Cambridge Street, Brighton, MA 02135, USA
    Thorac Surg Clin 14:417-28. 2004
  7. ncbi Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumes
    Bartolome Celli
    Pulmonary and Critical Care Division, St Elizabeth s Medical Center, Boston, MA 02135, USA
    Chest 124:1743-8. 2003
  8. ncbi Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper
    B R Celli
    Pulmonary and Critical Care Division, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Eur Respir J 23:932-46. 2004
  9. ncbi Pulmonary rehabilitation
    Bartolome R Celli
    St Elizabeth s Medical Center, Tufts University, Boston, MA, USA
    Isr Med Assoc J 5:443-8. 2003
  10. doi Cardiovascular safety of tiotropium in patients with COPD
    Bartolome Celli
    Carita St Elizabeth s Medical Center, Boston, MA, USA
    Chest 137:20-30. 2010

Detail Information

Publications56

  1. ncbi Roger s. Mitchell lecture. Chronic obstructive pulmonary disease phenotypes and their clinical relevance
    Bartolome R Celli
    Pulmonary and Critical Care Services, Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, MA 02135, USA
    Proc Am Thorac Soc 3:461-5. 2006
    ..The hope is that, coupled with primary and secondary prevention, we can reverse the current epidemic and we can improve the well-being of patients affected by COPD...
  2. ncbi Chronic obstructive pulmonary disease: from unjustified nihilism to evidence-based optimism
    Bartolome R Celli
    Department of Medicine, Tufts University
    Proc Am Thorac Soc 3:58-65. 2006
    ..The advent of newer and more effective therapies will lead to a decline in the contribution of this disease to poor world health...
  3. ncbi Change in the BODE index reflects disease modification in COPD: lessons from lung volume reduction surgery
    Bartolome R Celli
    Chest 129:835-6. 2006
  4. ncbi Predicting mortality in chronic obstructive pulmonary disease: chasing the "Holy Grail"
    Bartolome R Celli
    Am J Respir Crit Care Med 173:1298-9. 2006
  5. ncbi Systemic cytokines, clinical and physiological changes in patients hospitalized for exacerbation of COPD
    Victor M Pinto-Plata
    Division of Pulmonary and Critical Care Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Chest 131:37-43. 2007
    ..Systemic inflammation in patients with COPD may worsen during exacerbations, but there is limited information relating levels of systemic inflammatory markers with symptoms and physiologic changes during an exacerbation..
  6. ncbi Chronic respiratory failure after lung resection: the role of pulmonary rehabilitation
    Bartolome R Celli
    Division of Pulmonary and Critical Care Medicine, Caritas St Elizabeth s Medical Center, Seton 3 Pulmonary, 736 Cambridge Street, Brighton, MA 02135, USA
    Thorac Surg Clin 14:417-28. 2004
    ..Currently, pulmonary rehabilitation should be made available to all patients with symptomatic respiratory disease and be an integral part of any program considering high-risk surgery...
  7. ncbi Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumes
    Bartolome Celli
    Pulmonary and Critical Care Division, St Elizabeth s Medical Center, Boston, MA 02135, USA
    Chest 124:1743-8. 2003
    ..We sought to evaluate changes in resting IC and lung volumes after long-term administration of tiotropium...
  8. ncbi Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper
    B R Celli
    Pulmonary and Critical Care Division, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Eur Respir J 23:932-46. 2004
  9. ncbi Pulmonary rehabilitation
    Bartolome R Celli
    St Elizabeth s Medical Center, Tufts University, Boston, MA, USA
    Isr Med Assoc J 5:443-8. 2003
  10. doi Cardiovascular safety of tiotropium in patients with COPD
    Bartolome Celli
    Carita St Elizabeth s Medical Center, Boston, MA, USA
    Chest 137:20-30. 2010
    ..The clinical trial safety database for tiotropium has been augmented with a 4-year trial in patients with COPD, which provides an opportunity to better evaluate the cardiovascular (CV) profile of tiotropium...
  11. pmc Profiling serum biomarkers in patients with COPD: associations with clinical parameters
    Victor Pinto-Plata
    Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, Massachusetts 02135, USA
    Thorax 62:595-601. 2007
    ..A systematic analysis was undertaken of multiple protein analytes in the serum of well characterised patients with COPD and matched controls using novel protein microarray platform (PMP) technology...
  12. doi Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary disease
    Bartolome Celli
    Brigham and Women s Hospital and St Elizabeth s Medical Center, Boston, MA 02115, USA
    Am J Respir Crit Care Med 180:948-55. 2009
    ..Mortality and its causes was a secondary endpoint in UPLIFT...
  13. doi Effect of tiotropium in men and women with COPD: results of the 4-year UPLIFT trial
    Donald Tashkin
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1690, USA
    Respir Med 104:1495-504. 2010
    ..Gender differences may occur in many chronic diseases. We have examined the influence of gender in chronic obstructive pulmonary disease (COPD) on long-term responses to tiotropium...
  14. pmc Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease
    Deog Kyeom Kim
    Channing Division of Network Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 186:1238-47. 2012
    ..A genome-wide association study (GWAS) for circulating chronic obstructive pulmonary disease (COPD) biomarkers could identify genetic determinants of biomarker levels and COPD susceptibility...
  15. ncbi Biological lung volume reduction: a new bronchoscopic therapy for advanced emphysema
    John Reilly
    Brigham and Women s Hospital, Pulmonary Critical Care Medicine, 75 Francis St, Boston, MA 02115 6110, USA
    Chest 131:1108-13. 2007
    ..This report summarizes the initial clinical experience including a 3-month follow-up using this technique in humans...
  16. doi Resting handgrip force and impaired cardiac function at rest and during exercise in COPD patients
    Felipe Cortopassi
    Division of Pulmonary, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Respir Med 105:748-54. 2011
    ..Cardiac function measured as the oxygen pulse (O(2) pulse) is impaired during exercise (CPET) in patients with COPD. We investigated the relationship between handgrip force and O(2) pulse in COPD and controls...
  17. pmc Characterizing functional lung heterogeneity in COPD using reference equations for CT scan-measured lobar volumes
    Carolyn E Come
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 143:1607-17. 2013
    ..Using COPDGene data, we developed reference equations for lobar volumes at maximal inflation (total lung capacity [TLC]) and relaxed exhalation (approximating functional residual capacity [FRC])...
  18. ncbi Power of outcome measurements to detect clinically significant changes in pulmonary rehabilitation of patients with COPD
    Juan Pablo de Torres
    Pulmonary and Critical Care Division, St Elizabeth s Medical Center, Boston 02135 2997, USA
    Chest 121:1092-8. 2002
    ..We designed this study to investigate the capacity of several of the most frequently used outcome measurements to detect changes after PR in a population of patients with severe COPD who qualified for lung volume reduction surgery...
  19. doi Sex differences in mortality and clinical expressions of patients with chronic obstructive pulmonary disease. The TORCH experience
    Bartolome Celli
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 183:317-22. 2011
    ..Objectives: Determine sex differences in survival, causes of death, and patient-centered outcomes in the 3-year Toward a Revolution in COPD Health (TORCH) study...
  20. ncbi Future perspectives in COPD
    Bartolome Celli
    Caritas St Elizabeth s Medical Center, Department of Medicine, Tufts University, Boston, USA
    Respir Med 99:S41-8. 2005
    ..Many questions remain to be answered, but a comprehensive approach is now considered essential to the life-long management of COPD, and will undoubtedly reduce the considerable socio-economic burden of COPD...
  21. pmc A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 21:947-57. 2012
    ..08 and 0.04) and severe (GOLD 3&4) COPD (P = 0.09 and 0.017). This region includes RAB4B, EGLN2, MIA and CYP2A6, and has previously been identified in association with cigarette smoking behavior...
  22. doi Cardiopulmonary exercise testing: relevant but underused
    Daniel E Forman
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Postgrad Med 122:68-86. 2010
    ..In this article, we provide an overview of CPX principles and testing logistics, as well as some of the clinical contexts in which it can enhance patient care...
  23. doi Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease
    Miguel Divo
    Pulmonary and Critical Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Respir Crit Care Med 186:155-61. 2012
    ..Patients with chronic obstructive pulmonary disease (COPD) are afflicted by comorbidities. Few studies have prospectively evaluated COPD comorbidities and mortality risk...
  24. ncbi Physiologic responses to long-term ventilation
    Katherine Hendra
    Division of Pulmonary and Critical Care, Tufts University School of Medicine, St Elizabeths Medical Center, 736 Cambridge Street, Boston, MA 02135, USA
    Respir Care Clin N Am 8:447-62. 2002
    ..For some patients, particularly patients with fibrotic lung disease or COPD, chronic MV likely does not alter pathophysiology or improve prognosis...
  25. ncbi Use of proteomic patterns of serum biomarkers in patients with chronic obstructive pulmonary disease: correlation with clinical parameters
    Victor Pinto-Plata
    Pulmonary Critical Care Medicine, Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, MA 02135
    Proc Am Thorac Soc 3:465-6. 2006
  26. pmc Genome-wide association study of smoking behaviours in patients with COPD
    Mateusz Siedlinski
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Thorax 66:894-902. 2011
    ..Associations of CHRNA3/CHRNA5 and CYP2A6 loci with CPD and DBH with smoking cessation are also likely of importance in the smoking behaviours of patients with COPD...
  27. ncbi Tracheobronchitis caused by methicillin-resistant Staphylococcus aureus as a cause of chronic wheezing in a non-ventilated adult patient with tracheobronchomalacia
    Theodoros Kelesidis
    Department of Medicine, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Respiration 80:148-56. 2010
    ..Physicians should be aware of the diagnosis of tracheomalacia in adults, which can masquerade as persistent asthma and may be associated with the development of serious infections including MRSA tracheobronchitis...
  28. ncbi Gene expression profiling of human lung tissue from smokers with severe emphysema
    Avrum Spira
    The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, R304, Boston, MA 02118, USA
    Am J Respir Cell Mol Biol 31:601-10. 2004
    ....
  29. ncbi What is the best pharmacological treatment to prevent exacerbation of chronic obstructive pulmonary disease?
    Bartolome R Celli
    Pol Arch Med Wewn 118:172-4. 2008
  30. ncbi The 6-min walk distance, peak oxygen uptake, and mortality in COPD
    Claudia G Cote
    Pulmonary and Critical Care Medicine, Bay Pines VA Health Care System, 10, 000 Bay Pines Blvd, Bay Pines, FL 33744, USA
    Chest 132:1778-85. 2007
    ..993 to 0.999; p < 0.01) had a stronger association than the peak Vo2 (HR, 0.971; 95% CI, 0.959 to 1.000; p = 0.050) with mortality. This study shows the 6MWD is as good predictor of mortality as the peak Vo2 in patients with COPD...
  31. doi Predictors of Survival in COPD: more than just the FEV1
    Bartolome R Celli
    Caritas St Elizabeth s Medical Center, Boston, MA, USA
    Respir Med 102:S27-35. 2008
    ....
  32. ncbi Differences in cardiopulmonary exercise test results by American Thoracic Society/European Respiratory Society-Global Initiative for Chronic Obstructive Lung Disease stage categories and gender
    Victor M Pinto-Plata
    Division of Pulmonary, Critical Care and Sleep Medicine, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge St, Boston, MA 02135, USA
    Chest 132:1204-11. 2007
    ..We hypothesized that exercise performance measured by cardiopulmonary exercise test (CPET) results should decline significantly with each disease stage, independent of gender...
  33. pmc Longitudinal change in the BODE index predicts mortality in severe emphysema
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0360, USA
    Am J Respir Crit Care Med 178:491-9. 2008
    ..We hypothesized that decrease in a modified BODE (mBODE) would predict survival in National Emphysema Treatment Trial (NETT) patients...
  34. ncbi Update on the management of COPD
    Bartolome R Celli
    Pulmonary and Critical Care Medicine, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
    Chest 133:1451-62. 2008
    ..Ultimately, the advent of newer and more effective therapies will lead to a decline in the contribution of this disease to poor world health...
  35. doi Distance and oxygen desaturation during the 6-min walk test as predictors of long-term mortality in patients with COPD
    Ciro Casanova
    Pulmonary Department, Hospital La Candelaria, Carretera del Rosario n degrees 145, 38010 Santa Cruz de Tenerife, Spain
    Chest 134:746-52. 2008
    ..Little is known about its prognostic value in patients with a wider range of COPD severity, living in different countries, and the potential additional impact of oxygen desaturation measured during the test...
  36. pmc Gender and respiratory factors associated with dyspnea in chronic obstructive pulmonary disease
    Juan P de Torres
    Respiratory Research Unit, Hospital Nuestra Sra de Candelaria, Tenerife, Spain
    Respir Res 8:18. 2007
    ..We had shown that COPD women expressed more dyspnea than men for the same degree of airway obstruction...
  37. ncbi Pulmonary rehabilitation improves depression, anxiety, dyspnea and health status in patients with COPD
    Hildegarde Paz-Díaz
    Pulmonary Division, Hospital Universitario de Caracas, Universidad Central de Venezuela, Caracas, Venezuela
    Am J Phys Med Rehabil 86:30-6. 2007
    ..To determine the impact of an 8-wk program of comprehensive pulmonary rehabilitation on depression, anxiety, dyspnea, and health-related quality of life in patients with chronic obstructive pulmonary disease (COPD)...
  38. ncbi Muscle strength and exercise kinetics in COPD patients with a normal fat-free mass index are comparable to control subjects
    Yvonne F Heijdra
    Pulmonary Department, University Medical Center St Radboud, Nijmegen, The Netherlands
    Chest 124:75-82. 2003
    ....
  39. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
    ..We hypothesized that a multidimensional grading system that assessed the respiratory and systemic expressions of COPD would better categorize and predict outcome in these patients...
  40. ncbi New treatment strategies for COPD. Pairing the new with the tried and true
    Claudia G Cote
    University of South Florida College of Medicine, Tampa, USA
    Postgrad Med 117:27-34. 2005
    ..With all of these options, a nihilistic attitude toward management of COPD is not justified...
  41. ncbi Markers of disease severity in chronic obstructive pulmonary disease
    Luigi G Franciosi
    Gorlaeus Laboratories, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Pulm Pharmacol Ther 19:189-99. 2006
    ....
  42. ncbi Gender and COPD in patients attending a pulmonary clinic
    Juan P de Torres
    Respiratory Research Unit, Hospital Nuestra Sra de Candelaria, Tenerife, Spain
    Chest 128:2012-6. 2005
    ..To compare gender differences in the clinical expression of COPD patients attending a pulmonary clinic...
  43. ncbi Proposal for a multidimensional staging system for chronic obstructive pulmonary disease
    Bartolome R Celli
    Department of Pulmonary and Critical Care Medicine, Tufts University, Boston, MA 02135, USA
    Respir Med 99:1546-54. 2005
    ..Although the staging boundaries were based on existing literature, they have proven useful in predicting survival. We conclude that a multidimensional grading system is useful to assess the impact of COPD...
  44. ncbi Physician and patient perceptions in COPD: the COPD Resource Network Needs Assessment Survey
    R Graham Barr
    Division of General Medicine, Department of Medicine, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Med 118:1415. 2005
    ..National data are lacking on patient and physician perceptions of and patterns of care for COPD...
  45. pmc Markers of exacerbation severity in chronic obstructive pulmonary disease
    Luigi G Franciosi
    Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Respir Res 7:74. 2006
    ..In an attempt to find the best surrogates for exacerbations, we have reviewed the literature to identify which of these markers change in a consistent manner with the severity of the exacerbation event...
  46. ncbi Cough and phlegm are important predictors of health status in smokers without COPD
    Yvonne F Heijdra
    Pulmonary Department, University Medical Center, St Radboud, Nijmegen, The Netherlands
    Chest 121:1427-33. 2002
    ..Therefore, the aim of the study was to explore whether the differences in quality of life between smokers and ex-smokers could be explained by cough and phlegm, differences in pulmonary function tests, or exercise capacity...
  47. ncbi A 62-year-old woman with chronic obstructive pulmonary disease
    Bartolome R Celli
    Tufts University, USA
    JAMA 290:2721-9. 2003
  48. ncbi C-reactive protein levels and survival in patients with moderate to very severe COPD
    Juan P de Torres
    Respiratory Research Unit, Hospital Ntra Sra de Candelaria, Canary Islands, Tenerife, Spain
    Chest 133:1336-43. 2008
    ..In epidemiologic studies, CRP level is associated with all-cause mortality in patients with mild-to-moderate disease...
  49. ncbi A comparison of 5-day courses of dirithromycin and azithromycin in the treatment of acute exacerbations of chronic obstructive pulmonary disease
    Richard S Castaldo
    SUNY Buffalo School of Medicine, Buffalo, New York, USA
    Clin Ther 25:542-57. 2003
    ..The macrolide antibiotics, particularly second-generation agents such as dirithromycin and azithromycin, are among the antibiotic classes frequently recommended and used to treat upper and lower respiratory infections, including AECB...
  50. ncbi Deep breath reversal and exponential return of methacholine-induced obstruction in asthmatic and nonasthmatic subjects
    Andrew C Jackson
    Biomedical Engineering Dept, Boston Univ, 44 Cummington St, Boston, MA 02215, USA
    J Appl Physiol (1985) 96:137-42. 2004
    ..19 +/- 4.95 and 7.14 +/- 3.56 cmH2O.l-1.s, respectively). The monoexponential recovery suggests a first-order process such as airway wall-parenchymal tissue interdependence or renewed constriction of airway smooth muscle...
  51. pmc Gender associated differences in determinants of quality of life in patients with COPD: a case series study
    Juan P de Torres
    Respiratory Research Unit, Hospital Nuestra Sra de Candelaria, Tenerife, Spain
    Health Qual Life Outcomes 4:72. 2006
    ..Quality of Life (QoL) has become an important outcome in COPD patients. The aim of our study was to explore factors contributing to gender differences in Quality of Life of COPD patients...
  52. ncbi Inspiratory-to-total lung capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease
    Ciro Casanova
    Respiratory Research Institute, Hospital Universitario La Candelaria, Carretera del Rosario s n, 38010 Santa Cruz de Tenerife, Spain
    Am J Respir Crit Care Med 171:591-7. 2005
    ..We propose that this ratio be considered in the assessment of patients with chronic obstructive pulmonary disease...
  53. ncbi Predictors of mortality in chronic obstructive pulmonary disease
    Claudia G Cote
    University of South Florida, Tampa, FL, USA
    Clin Chest Med 28:515-24, v. 2007
    ..It also discusses the ability of an integrated, multidimensional tool to more broadly characterize COPD severity, assess response to therapeutic interventions and exacerbations, and predict mortality...
  54. ncbi Airway obstruction in never smokers: results from the Third National Health and Nutrition Examination Survey
    Bartolome R Celli
    Caritas St Elizabeth s Medical Center, Tufts University Medical School, Boston, Mass, USA
    Am J Med 118:1364-72. 2005
    ..COPD is rarely considered in persons with no smoking history except in the context of another exposure. Accordingly, the disease has not been well characterized in these "never smokers."..
  55. ncbi Lung volume reduction surgery vs medical treatment: for patients with advanced emphysema
    John D Miller
    McMaster University, Hamilton Ontarion, Canada
    Chest 127:1166-77. 2005
    ..To contribute to the knowledge on the therapeutic value of lung volume reduction surgery (LVRS)...
  56. ncbi Discrepancy in the use of confirmatory tests in patients hospitalized with the diagnosis of chronic obstructive pulmonary disease or congestive heart failure
    Mahendra Damarla
    Division of Pulmonary and Critical Care Medicine, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    Respir Care 51:1120-4. 2006
    ....