Genomes and Genes
Affiliation: Tufts University School of Medicine
- Roger s. Mitchell lecture. Chronic obstructive pulmonary disease phenotypes and their clinical relevanceBartolome R Celli
Pulmonary and Critical Care Services, Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, MA 02135, USA
Proc Am Thorac Soc 3:461-5. 2006..The hope is that, coupled with primary and secondary prevention, we can reverse the current epidemic and we can improve the well-being of patients affected by COPD...
- Chronic obstructive pulmonary disease: from unjustified nihilism to evidence-based optimismBartolome R Celli
Department of Medicine, Tufts University
Proc Am Thorac Soc 3:58-65. 2006..The advent of newer and more effective therapies will lead to a decline in the contribution of this disease to poor world health...
- Change in the BODE index reflects disease modification in COPD: lessons from lung volume reduction surgeryBartolome R Celli
Chest 129:835-6. 2006
- Predicting mortality in chronic obstructive pulmonary disease: chasing the "Holy Grail"Bartolome R Celli
Am J Respir Crit Care Med 173:1298-9. 2006
- Systemic cytokines, clinical and physiological changes in patients hospitalized for exacerbation of COPDVictor M Pinto-Plata
Division of Pulmonary and Critical Care Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
Chest 131:37-43. 2007..Systemic inflammation in patients with COPD may worsen during exacerbations, but there is limited information relating levels of systemic inflammatory markers with symptoms and physiologic changes during an exacerbation..
- Chronic respiratory failure after lung resection: the role of pulmonary rehabilitationBartolome R Celli
Division of Pulmonary and Critical Care Medicine, Caritas St Elizabeth s Medical Center, Seton 3 Pulmonary, 736 Cambridge Street, Brighton, MA 02135, USA
Thorac Surg Clin 14:417-28. 2004..Currently, pulmonary rehabilitation should be made available to all patients with symptomatic respiratory disease and be an integral part of any program considering high-risk surgery...
- Pulmonary rehabilitationBartolome R Celli
St Elizabeth s Medical Center, Tufts University, Boston, MA, USA
Isr Med Assoc J 5:443-8. 2003
- Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paperB R Celli
Pulmonary and Critical Care Division, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
Eur Respir J 23:932-46. 2004
- Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumesBartolome Celli
Pulmonary and Critical Care Division, St Elizabeth s Medical Center, Boston, MA 02135, USA
Chest 124:1743-8. 2003..We sought to evaluate changes in resting IC and lung volumes after long-term administration of tiotropium...
- Cardiovascular safety of tiotropium in patients with COPDBartolome Celli
Carita St Elizabeth s Medical Center, Boston, MA, USA
Chest 137:20-30. 2010..The clinical trial safety database for tiotropium has been augmented with a 4-year trial in patients with COPD, which provides an opportunity to better evaluate the cardiovascular (CV) profile of tiotropium...
- Profiling serum biomarkers in patients with COPD: associations with clinical parametersVictor Pinto-Plata
Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, Massachusetts 02135, USA
Thorax 62:595-601. 2007..A systematic analysis was undertaken of multiple protein analytes in the serum of well characterised patients with COPD and matched controls using novel protein microarray platform (PMP) technology...
- Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary diseaseBartolome Celli
Brigham and Women s Hospital and St Elizabeth s Medical Center, Boston, MA 02115, USA
Am J Respir Crit Care Med 180:948-55. 2009..Mortality and its causes was a secondary endpoint in UPLIFT...
- Effect of tiotropium in men and women with COPD: results of the 4-year UPLIFT trialDonald Tashkin
Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1690, USA
Respir Med 104:1495-504. 2010..Gender differences may occur in many chronic diseases. We have examined the influence of gender in chronic obstructive pulmonary disease (COPD) on long-term responses to tiotropium...
- Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary diseaseDeog Kyeom Kim
Channing Division of Network Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 186:1238-47. 2012..A genome-wide association study (GWAS) for circulating chronic obstructive pulmonary disease (COPD) biomarkers could identify genetic determinants of biomarker levels and COPD susceptibility...
- Biological lung volume reduction: a new bronchoscopic therapy for advanced emphysemaJohn Reilly
Brigham and Women s Hospital, Pulmonary Critical Care Medicine, 75 Francis St, Boston, MA 02115 6110, USA
Chest 131:1108-13. 2007..This report summarizes the initial clinical experience including a 3-month follow-up using this technique in humans...
- Genetic control of gene expression at novel and established chronic obstructive pulmonary disease lociPeter J Castaldi
Channing Division of Network Medicine, Brigham and Women s Hospital, Boston, USA, Division of General Internal Medicine and Primary Care and
Hum Mol Genet 24:1200-10. 2015....
- Resting handgrip force and impaired cardiac function at rest and during exercise in COPD patientsFelipe Cortopassi
Division of Pulmonary, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
Respir Med 105:748-54. 2011..Cardiac function measured as the oxygen pulse (O(2) pulse) is impaired during exercise (CPET) in patients with COPD. We investigated the relationship between handgrip force and O(2) pulse in COPD and controls...
- Characterizing functional lung heterogeneity in COPD using reference equations for CT scan-measured lobar volumesCarolyn E Come
Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Chest 143:1607-17. 2013..Using COPDGene data, we developed reference equations for lobar volumes at maximal inflation (total lung capacity [TLC]) and relaxed exhalation (approximating functional residual capacity [FRC])...
- Future perspectives in COPDBartolome Celli
Caritas St Elizabeth s Medical Center, Department of Medicine, Tufts University, Boston, USA
Respir Med 99:S41-8. 2005..Many questions remain to be answered, but a comprehensive approach is now considered essential to the life-long management of COPD, and will undoubtedly reduce the considerable socio-economic burden of COPD...
- Sex differences in mortality and clinical expressions of patients with chronic obstructive pulmonary disease. The TORCH experienceBartolome Celli
Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 183:317-22. 2011..There is limited knowledge regarding sex differences and outcomes in patients with chronic obstructive pulmonary disease (COPD)...
- Power of outcome measurements to detect clinically significant changes in pulmonary rehabilitation of patients with COPDJuan Pablo de Torres
Pulmonary and Critical Care Division, St Elizabeth s Medical Center, Boston 02135 2997, USA
Chest 121:1092-8. 2002..We designed this study to investigate the capacity of several of the most frequently used outcome measurements to detect changes after PR in a population of patients with severe COPD who qualified for lung volume reduction surgery...
- A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13Michael H Cho
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Hum Mol Genet 21:947-57. 2012..08 and 0.04) and severe (GOLD 3&4) COPD (P = 0.09 and 0.017). This region includes RAB4B, EGLN2, MIA and CYP2A6, and has previously been identified in association with cigarette smoking behavior...
- Cardiopulmonary exercise testing: relevant but underusedDaniel E Forman
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Postgrad Med 122:68-86. 2010..In this article, we provide an overview of CPX principles and testing logistics, as well as some of the clinical contexts in which it can enhance patient care...
- Sexually-dimorphic targeting of functionally-related genes in COPDKimberly Glass
Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA, USA
BMC Syst Biol 8:118. 2014..However, there are few methods to identify and characterize differences in network structure, slowing progress in understanding mechanisms driving sexual dimorphism...
- Comorbidities and risk of mortality in patients with chronic obstructive pulmonary diseaseMiguel Divo
Pulmonary and Critical Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Respir Crit Care Med 186:155-61. 2012..Patients with chronic obstructive pulmonary disease (COPD) are afflicted by comorbidities. Few studies have prospectively evaluated COPD comorbidities and mortality risk...
- Genome-wide association study of smoking behaviours in patients with COPDMateusz Siedlinski
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Thorax 66:894-902. 2011..Associations of CHRNA3/CHRNA5 and CYP2A6 loci with CPD and DBH with smoking cessation are also likely of importance in the smoking behaviours of patients with COPD...
- Physiologic responses to long-term ventilationKatherine Hendra
Division of Pulmonary and Critical Care, Tufts University School of Medicine, St Elizabeths Medical Center, 736 Cambridge Street, Boston, MA 02135, USA
Respir Care Clin N Am 8:447-62. 2002..For some patients, particularly patients with fibrotic lung disease or COPD, chronic MV likely does not alter pathophysiology or improve prognosis...
- Use of proteomic patterns of serum biomarkers in patients with chronic obstructive pulmonary disease: correlation with clinical parametersVictor Pinto-Plata
Pulmonary Critical Care Medicine, Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, MA 02135
Proc Am Thorac Soc 3:465-6. 2006
- Tracheobronchitis caused by methicillin-resistant Staphylococcus aureus as a cause of chronic wheezing in a non-ventilated adult patient with tracheobronchomalaciaTheodoros Kelesidis
Department of Medicine, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
Respiration 80:148-56. 2010..Physicians should be aware of the diagnosis of tracheomalacia in adults, which can masquerade as persistent asthma and may be associated with the development of serious infections including MRSA tracheobronchitis...
- Gene expression profiling of human lung tissue from smokers with severe emphysemaAvrum Spira
The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, R304, Boston, MA 02118, USA
Am J Respir Cell Mol Biol 31:601-10. 2004....
- Distance and oxygen desaturation during the 6-min walk test as predictors of long-term mortality in patients with COPDCiro Casanova
Pulmonary Department, Hospital La Candelaria, Carretera del Rosario n degrees 145, 38010 Santa Cruz de Tenerife, Spain
Chest 134:746-52. 2008..Little is known about its prognostic value in patients with a wider range of COPD severity, living in different countries, and the potential additional impact of oxygen desaturation measured during the test...
- Differences in cardiopulmonary exercise test results by American Thoracic Society/European Respiratory Society-Global Initiative for Chronic Obstructive Lung Disease stage categories and genderVictor M Pinto-Plata
Division of Pulmonary, Critical Care and Sleep Medicine, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge St, Boston, MA 02135, USA
Chest 132:1204-11. 2007..We hypothesized that exercise performance measured by cardiopulmonary exercise test (CPET) results should decline significantly with each disease stage, independent of gender...
- Longitudinal change in the BODE index predicts mortality in severe emphysemaFernando J Martinez
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0360, USA
Am J Respir Crit Care Med 178:491-9. 2008..We hypothesized that decrease in a modified BODE (mBODE) would predict survival in National Emphysema Treatment Trial (NETT) patients...
- Update on the management of COPDBartolome R Celli
Pulmonary and Critical Care Medicine, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
Chest 133:1451-62. 2008..Ultimately, the advent of newer and more effective therapies will lead to a decline in the contribution of this disease to poor world health...
- What is the best pharmacological treatment to prevent exacerbation of chronic obstructive pulmonary disease?Bartolome R Celli
Pol Arch Med Wewn 118:172-4. 2008
- Predictors of Survival in COPD: more than just the FEV1Bartolome R Celli
Caritas St Elizabeth s Medical Center, Boston, MA, USA
Respir Med 102:S27-35. 2008....
- A 62-year-old woman with chronic obstructive pulmonary diseaseBartolome R Celli
Tufts University, USA
JAMA 290:2721-9. 2003
- Gender and respiratory factors associated with dyspnea in chronic obstructive pulmonary diseaseJuan P de Torres
Respiratory Research Unit, Hospital Nuestra Sra de Candelaria, Tenerife, Spain
Respir Res 8:18. 2007..We had shown that COPD women expressed more dyspnea than men for the same degree of airway obstruction...
- Physician and patient perceptions in COPD: the COPD Resource Network Needs Assessment SurveyR Graham Barr
Division of General Medicine, Department of Medicine, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY, USA
Am J Med 118:1415. 2005..National data are lacking on patient and physician perceptions of and patterns of care for COPD...
- Proposal for a multidimensional staging system for chronic obstructive pulmonary diseaseBartolome R Celli
Department of Pulmonary and Critical Care Medicine, Tufts University, Boston, MA 02135, USA
Respir Med 99:1546-54. 2005..Although the staging boundaries were based on existing literature, they have proven useful in predicting survival. We conclude that a multidimensional grading system is useful to assess the impact of COPD...
- Gender and COPD in patients attending a pulmonary clinicJuan P de Torres
Respiratory Research Unit, Hospital Nuestra Sra de Candelaria, Tenerife, Spain
Chest 128:2012-6. 2005..To compare gender differences in the clinical expression of COPD patients attending a pulmonary clinic...
- Markers of disease severity in chronic obstructive pulmonary diseaseLuigi G Franciosi
Gorlaeus Laboratories, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
Pulm Pharmacol Ther 19:189-99. 2006....
- New treatment strategies for COPD. Pairing the new with the tried and trueClaudia G Cote
University of South Florida College of Medicine, Tampa, USA
Postgrad Med 117:27-34. 2005..With all of these options, a nihilistic attitude toward management of COPD is not justified...
- The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary diseaseBartolome R Celli
COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
N Engl J Med 350:1005-12. 2004..We hypothesized that a multidimensional grading system that assessed the respiratory and systemic expressions of COPD would better categorize and predict outcome in these patients...
- Muscle strength and exercise kinetics in COPD patients with a normal fat-free mass index are comparable to control subjectsYvonne F Heijdra
Pulmonary Department, University Medical Center St Radboud, Nijmegen, The Netherlands
Chest 124:75-82. 2003....
- Markers of exacerbation severity in chronic obstructive pulmonary diseaseLuigi G Franciosi
Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
Respir Res 7:74. 2006..In an attempt to find the best surrogates for exacerbations, we have reviewed the literature to identify which of these markers change in a consistent manner with the severity of the exacerbation event...
- Pulmonary rehabilitation improves depression, anxiety, dyspnea and health status in patients with COPDHildegarde Paz-Díaz
Pulmonary Division, Hospital Universitario de Caracas, Universidad Central de Venezuela, Caracas, Venezuela
Am J Phys Med Rehabil 86:30-6. 2007..To determine the impact of an 8-wk program of comprehensive pulmonary rehabilitation on depression, anxiety, dyspnea, and health-related quality of life in patients with chronic obstructive pulmonary disease (COPD)...
- Cough and phlegm are important predictors of health status in smokers without COPDYvonne F Heijdra
Pulmonary Department, University Medical Center, St Radboud, Nijmegen, The Netherlands
Chest 121:1427-33. 2002..Therefore, the aim of the study was to explore whether the differences in quality of life between smokers and ex-smokers could be explained by cough and phlegm, differences in pulmonary function tests, or exercise capacity...
- The 6-min walk distance, peak oxygen uptake, and mortality in COPDClaudia G Cote
Pulmonary and Critical Care Medicine, Bay Pines VA Health Care System, 10, 000 Bay Pines Blvd, Bay Pines, FL 33744, USA
Chest 132:1778-85. 2007..993 to 0.999; p < 0.01) had a stronger association than the peak Vo2 (HR, 0.971; 95% CI, 0.959 to 1.000; p = 0.050) with mortality. This study shows the 6MWD is as good predictor of mortality as the peak Vo2 in patients with COPD...
- C-reactive protein levels and survival in patients with moderate to very severe COPDJuan P de Torres
Respiratory Research Unit, Hospital Ntra Sra de Candelaria, Canary Islands, Tenerife, Spain
Chest 133:1336-43. 2008..In epidemiologic studies, CRP level is associated with all-cause mortality in patients with mild-to-moderate disease...
- A comparison of 5-day courses of dirithromycin and azithromycin in the treatment of acute exacerbations of chronic obstructive pulmonary diseaseRichard S Castaldo
SUNY Buffalo School of Medicine, Buffalo, New York, USA
Clin Ther 25:542-57. 2003..The macrolide antibiotics, particularly second-generation agents such as dirithromycin and azithromycin, are among the antibiotic classes frequently recommended and used to treat upper and lower respiratory infections, including AECB...
- Deep breath reversal and exponential return of methacholine-induced obstruction in asthmatic and nonasthmatic subjectsAndrew C Jackson
Biomedical Engineering Dept, Boston Univ, 44 Cummington St, Boston, MA 02215, USA
J Appl Physiol (1985) 96:137-42. 2004..19 +/- 4.95 and 7.14 +/- 3.56 cmH2O.l-1.s, respectively). The monoexponential recovery suggests a first-order process such as airway wall-parenchymal tissue interdependence or renewed constriction of airway smooth muscle...
- Predictors of mortality in chronic obstructive pulmonary diseaseClaudia G Cote
University of South Florida, Tampa, FL, USA
Clin Chest Med 28:515-24, v. 2007..It also discusses the ability of an integrated, multidimensional tool to more broadly characterize COPD severity, assess response to therapeutic interventions and exacerbations, and predict mortality...
- Inspiratory-to-total lung capacity ratio predicts mortality in patients with chronic obstructive pulmonary diseaseCiro Casanova
Respiratory Research Institute, Hospital Universitario La Candelaria, Carretera del Rosario s n, 38010 Santa Cruz de Tenerife, Spain
Am J Respir Crit Care Med 171:591-7. 2005..We propose that this ratio be considered in the assessment of patients with chronic obstructive pulmonary disease...
- Gender associated differences in determinants of quality of life in patients with COPD: a case series studyJuan P de Torres
Respiratory Research Unit, Hospital Nuestra Sra de Candelaria, Tenerife, Spain
Health Qual Life Outcomes 4:72. 2006..Quality of Life (QoL) has become an important outcome in COPD patients. The aim of our study was to explore factors contributing to gender differences in Quality of Life of COPD patients...
- Discrepancy in the use of confirmatory tests in patients hospitalized with the diagnosis of chronic obstructive pulmonary disease or congestive heart failureMahendra Damarla
Division of Pulmonary and Critical Care Medicine, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
Respir Care 51:1120-4. 2006....
- Airway obstruction in never smokers: results from the Third National Health and Nutrition Examination SurveyBartolome R Celli
Caritas St Elizabeth s Medical Center, Tufts University Medical School, Boston, Mass, USA
Am J Med 118:1364-72. 2005..COPD is rarely considered in persons with no smoking history except in the context of another exposure. Accordingly, the disease has not been well characterized in these "never smokers."..
- Lung volume reduction surgery vs medical treatment: for patients with advanced emphysemaJohn D Miller
McMaster University, Hamilton Ontarion, Canada
Chest 127:1166-77. 2005..To contribute to the knowledge on the therapeutic value of lung volume reduction surgery (LVRS)...